Yuichi Yamaguchi, Tadatsugu Morimoto, Yu Toda, Masatsugu Tsukamoto, Tomohito Yoshihara, Hirohito Hirata, Takaomi Kobayashi, Masaaki Mawatari
Methotrexate (MTX) is a drug used for treating rheumatoid arthritis. Recently, the reported incidence of methotrexate-associated lymphoproliferative disease (MTX-LPD) has increased, especially in Japan. Extranodal involvement is observed in half of MTX-LPD cases. However, only a few spinal lesions have been reported, with none in the sacrum. Additionally, Epstein-Barr virus (EBV) infection has also been implicated in the pathogenesis of MTX-LPD. Herein, we describe the case of a 74-year-old woman with MTX-LPD in the sacral spine who complained of severe back pain and nocturnal pain...
January 2024: BJR Case Reports