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https://www.readbyqxmd.com/read/28647437/inhibitory-control-is-not-lateralized-in-parkinson-s-patients
#1
G Mirabella, M Fragola, G Giannini, N Modugno, Daniel Lakens
Parkinson's disease (PD) is often characterized by asymmetrical symptoms, which are more prominent on the side of the body contralateral to the most extensively affected brain hemisphere. Therefore, lateralized PD presents an opportunity to examine the effects of asymmetric subcortical dopamine deficiencies on cognitive functioning. As it has been hypothesized that inhibitory control relies upon a right-lateralized pathway, we tested whether left-dominant PD (LPD) patients suffered from a more severe deficit in this key executive function than right-dominant PD patients (RPD)...
June 21, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28626541/a-rare-case-of-three-distinct-epstein-barr-virus-associated-lymphoproliferative-disorders-over-sixteen-years-of-human-immunodeficiency-virus-infection
#2
Hamdy M A Ahmed, Abrar Khan, Weyman Lam, Samar Abohamad, Pradyumna Phatak
Epstein Barr virus (EBV) is well known to cause different types of malignancies. In immunocompromised patients, such as those infected with human immunodeficiency virus (HIV), there is a higher likelihood of EBV related malignant transformation. Diagnosis of EBV related malignancies may be difficult and sometimes requires clinical and pathological correlation. It is very rare to have more than one type of EBV related malignancy in a single patient. Until now, there are no specific guidelines for treatment of EBV related malignancies and lymphoproliferative disorders (LPD)...
June 1, 2017: Hematology Reports
https://www.readbyqxmd.com/read/28605998/primary-cutaneous-cd4-small-medium-pleomorphic-t-cell-lymphoproliferative-disorder-a-case-series
#3
Martina Maurelli, Chiara Colato, Paolo Gisondi, Giampiero Girolomoni
BACKGROUND: Primary cutaneous CD4(+) small/medium T-cell lymphoproliferative disorder (CD4(+) PCSM-LPD) is defined by a predominance of small- to medium-sized CD4(+) pleomorphic T cells and a favorable clinical course. OBJECTIVE: We performed a retrospective analysis of 6 patients with CD4(+) PCSM-LPD and reviewed the literature to address questions about its diagnosis, treatment, and prognosis. METHODS: Patients were 3 men and 3 women with a median age of 50 years...
June 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28597777/improved-metabolism-and-redox-state-with-a-novel-preservation-solution-implications-for-donor-lungs-after-cardiac-death-dcd
#4
David A Schipper, Anthony V Louis, Destiny S Dicken, Kitsie Johnson, Ryszard T Smolenski, Stephen M Black, Ray Runyan, John Konhilas, Joe G N Garcia, Zain Khalpey
Lungs donated after cardiac death (DCD) are an underutilized resource for a dwindling donor lung transplant pool. Our study investigates the potential of a novel preservation solution, Somah, to better preserve statically stored DCD lungs, for an extended time period, when compared to low-potassium dextran solution (LPD). We hypothesize that Somah is a metabolically superior organ preservation solution for hypothermic statically stored porcine DCD lungs, possibly improving lung transplant outcomes. Porcine DCD lungs (n = 3 per group) were flushed with and submerged in cold preservation solution...
April 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28597193/concentrate-supplementations-of-grazing-pregnant-kalahari-red-goats-effects-on-pregnancy-variables-reproductive-performance-birth-types-and-weight-of-kids
#5
O A Oderinwale, B O Oluwatosin, O S Sowande, M N Bemji, S D Amosu, G O Sanusi
A study was conducted for 22 weeks to determine the effects of concentrate supplementations at three crude protein (CP) levels, i.e. low protein diet-LPD 12.42% CP (124.93 g day(-1)); medium protein diet-MPD 14.18% CP (145.87 g day(-1)) and high protein diet-HPD 16.35% CP (168.19 g day(-1)) on some pregnancy variables, reproductive performance, birth types and weight of kids kidded by pregnant Kalahari Red goats grazed on Chloris gayana. Thirty-three matured Kalahari Red goats of first parity within age range of 2 to 2(1)/2 years with an average body weight of 38...
June 9, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28592786/epstein-barr-virus-associated-lymphoproliferative-disorders-review-and-update-on-2016-who-classification
#6
Hyun-Jung Kim, Young Hyeh Ko, Ji Eun Kim, Seung-Sook Lee, Hyekyung Lee, Gyeongsin Park, Jin Ho Paik, Hee Jeong Cha, Yoo-Duk Choi, Jae Ho Han, Jooryung Huh
Epstein-Barr virus (human herpesvirus-4) is very common virus that can be detected in more than 95% of the human population. Most people are asymptomatic and live their entire lives in a chronically infected state (IgG positive). However, in some populations, the Epstein-Barr virus (EBV) has been involved in the occurrence of a wide range of B-cell lymphoproliferative disorders (LPDs), including Burkitt lymphoma, classic Hodgkin's lymphoma, and immune-deficiency associated LPDs (post-transplant and human immunodeficiency virus-associated LPDs)...
June 5, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28591035/a-case-report-of-lymphoid-intestitial-pneumonia-in-common-variable-immunodeficiency-oligoclonal-expansion-of-effector-lymphocytes-with-preferential-cytomegalovirus-specific-immune-response-and-lymphoproliferative-disease-promotion
#7
Przemyslaw Zdziarski, Andrzej Gamian, Grzegorz Dworacki
RATIONALE: Lymphoid interstitial pneumonia (LIP) is a rare disease with lymphocytic infiltration of the alveolar interstitial and air spaces, sometimes classified as a clonal lymphoproliferative disease (LPD) with high prevalence in patients with immunodysregulation. Although association of mucosa-associated lymphoid tissue (MALT) lymphoma development with infectious agents has been well described, it is not so in the case of LIP. Attempts to demonstrate an infective cause by direct microbe detection have failed, but association with atypical specific immune response to opportunistic infectious agent has not been studied...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28574826/leflunomide-teriflunomide-inhibit-epstein-barr-virus-ebv-induced-lymphoproliferative-disease-and-lytic-viral-replication
#8
Andrea Bilger, Julie Plowshay, Shidong Ma, Dhananjay Nawandar, Elizabeth A Barlow, James C Romero-Masters, Jillian A Bristol, Zhe Li, Ming-Han Tsai, Henri-Jacques Delecluse, Shannon C Kenney
EBV infection causes mononucleosis and is associated with specific subsets of B cell lymphomas. Immunosuppressed patients such as organ transplant recipients are particularly susceptible to EBV-induced lymphoproliferative disease (LPD), which can be fatal. Leflunomide (a drug used to treat rheumatoid arthritis) and its active metabolite teriflunomide (used to treat multiple sclerosis) inhibit de novo pyrimidine synthesis by targeting the cellular dihydroorotate dehydrogenase, thereby decreasing T cell proliferation...
May 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28573819/use-of-eltrombopag-for-secondary-immune-thrombocytopenia-in-clinical-practice
#9
Tomás J González-López, María T Alvarez-Román, Cristina Pascual, Blanca Sánchez-González, Fernando Fernández-Fuentes, Gloria Pérez-Rus, José A Hernández-Rivas, Silvia Bernat, José M Bastida, María P Martínez-Badas, Violeta Martínez-Robles, Inmaculada Soto, Pavel Olivera, Estefanía Bolaños, Rafael Alonso, Laura Entrena, Marta Gómez-Nuñez, Arancha Alonso, María Yera Cobo, Isabel Caparrós, María Tenorio, Esther Arrieta-Cerdán, Elsa Lopez-Ansoar, Javier García-Frade, José R González-Porras
Eltrombopag is a second-line treatment in primary immune thrombocytopenia (ITP). However, its role in secondary ITP is unknown. We evaluated the efficacy and safety of eltrombopag in secondary ITP in daily clinical practice. Eighty-seven secondary ITP patients (46 with ITP secondary to autoimmune syndromes, 23 with ITP secondary to a neoplastic disease subtype: lymphoproliferative disorders [LPDs] and 18 with ITP secondary to viral infections) who had been treated with eltrombopag were retrospectively evaluated...
June 1, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28567575/analysis-of-the-cost-effectiveness-of-laparoscopic-pancreatoduodenectomy
#10
Michael H Gerber, Daniel Delitto, Cristina J Crippen, Thomas J George, Kevin E Behrns, Jose G Trevino, Jessica L Cioffi, Steven J Hughes
OBJECTIVE: We sought to determine if laparoscopic pancreatoduodenectomy (LPD) is a cost-effective alternative to open pancreatoduodenectomy (OPD). METHODS: Hospital cost data, discharge disposition, readmission rates, and readmission costs from periampullary cancer patient cohorts of LPD and OPD were compared. The surgical cohorts over a 40-month period were clinically similar, consisting of 52 and 50 patients in the LPD and OPD groups, respectively. RESULTS: The total operating room costs were higher in the LPD group as compared to the OPD group (median US$12,290 vs US$11,299; P = 0...
May 31, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28551662/feasibility-and-safety-of-repeated-transarterial-chemoembolization-using-miriplatin-lipiodol-suspension-for-hepatocellular-carcinoma
#11
Tomohiro Matsumoto, Hitoshi Ichikawa, Jin Imai, Toshihiko Hayashi, Kosuke Tomita, Takahiko Mine, Seiichiro Kojima, Norihito Watanabe, Terumitsu Hasebe
AIM: To retrospectively evaluate the feasibility and safety of repeated transarterial chemoembolization (TACE) three or more times using miriplatin-lipiodol (M-LPD) suspension (repeated M-LPD TACE) for hepatocellular carcinoma (HCC). PATIENTS AND METHODS: Sixteen patients who underwent repeated M-LPD TACE were examined. Total dose of miriplatin, lipiodol and porous gelatin sponge particles and adverse events of the first and last M-LPD TACE were evaluated. RESULTS: The mean±standard deviation (SD) of the total number of M-LPD TACE per patient was 3...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28538208/notch4-and-mhc%C3%A2-class-ii-polymorphisms-are-associated-with%C3%A2-hcv-related-benign-and-malignant-lymphoproliferative-diseases
#12
Laura Gragnani, Elisa Fognani, Valli De Re, Massimo Libra, Adriana Garozzo, Patrizio Caini, Guia Cerretelli, Andrea Giovannelli, Serena Lorini, Monica Monti, Silvia Bagnoli, Irene Piaceri, Anna Linda Zignego
Mixed cryoglobulinemia (MC), is a HCV-related, clinically benign, lymphoproliferative disorder (LPD) that may evolve into a non Hodgkin's lymphoma (NHL). Significant associations were found between two single nucleotide polymorphisms near NOTCH4 (rs2071286) and the HLA class II (rs9461776) genes and HCV-related MC syndrome (MCS). We analyzed NOTCH4 rs2071286 and HLA-II rs9461776 in 3 HCV-related LPD groups (asymptomatic MC, MCS, NHL) with HCV infection without lymphoproliferative disorders.We found a positive relationship between NOTCH4 rs207186 T minor allele frequency (MAF) and patients with HCV-related LPDs at risk of NHL (Chi-square test for trend = 14...
March 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28499895/epstein-barr-virus-and-rheumatoid-arthritis
#13
Nathalie Balandraud, Jean Roudier
Rheumatoid arthritis (RA) is one of the most common autoimmune diseases, with a 0.5% worldwide prevalence. The cause of RA remains unknown, however both genetic and environmental factors may contribute to its development. Among these is the Epstein-Barr virus (EBV). Here, we discuss several aspects of the close relationship between EBV and RA. Patients with RA have impaired control of EBV infection. Indeed, they have high titres of antibodies against EBV antigens. Their peripheral blood T lymphocytes are less efficient at controlling the outgrowth of EBV-infected B cells...
May 9, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28475591/ketoanalogues-supplementation-decreases-dialysis-and-mortality-risk-in-patients-with-anemic-advanced-chronic-kidney-disease
#14
Che-Hsiung Wu, Ya-Wen Yang, Szu-Chun Hung, Ko-Lin Kuo, Kwan-Dun Wu, Vin-Cent Wu, Tsung-Cheng Hsieh
BACKGROUND: The benefit of alpha-Ketoanalogues (KA) supplementation for chronic kidney disease (CKD) patients that followed low-protein diet (LPD) remains undetermined. METHODS: We extracted longitudinal data for all CKD patients in the Taiwan National Health Insurance from January 1, 2000 through December 31, 2010. A total of 1483 patients with anemic advanced CKD treated with LPD, who started KA supplementation, were enrolled in this study. We analyzed the risks of end stage renal disease and all-cause mortality using Cox proportional hazard models with influential drugs as time-dependent variables...
2017: PloS One
https://www.readbyqxmd.com/read/28472613/emerging-insights-on-the-pathogenesis-and-treatment-of-extranodal-nk-t-cell-lymphomas-enktl
#15
Bradley M Haverkos, Carrie Coleman, Alejandro A Gru, Zenggang Pan, Jonathan Brammer, Rosemary Rochford, Anjali Mishra, Christopher C Oakes, Robert A Baiocchi, Aharon G Freud, Pierluigi Porcu
Extranodal NK/T-cell lymphoma (ENKTL) is a rare aggressive extranodal non-Hodgkin lymphoma (NHL) universally associated with Epstein-Barr virus (EBV). ENKTL most commonly occurs in non-elderly immune competent males in Asia and South America. A number of antecedent lymphoproliferative disorders (LPDs) have been described in Asian and South American patients, but the majority of Caucasian ENKTL patients have no known preceding LPD or underlying immunodeficiency. Other than EBV, no environmental or extrinsic factor has been implicated in oncogenesis...
March 2017: Discovery Medicine
https://www.readbyqxmd.com/read/28468236/non-traditional-aspects-of-renal-diets-focus-on-fiber-alkali-and-vitamin-k1-intake
#16
Adamasco Cupisti, Claudia D'Alessandro, Loreto Gesualdo, Carmela Cosola, Maurizio Gallieni, Maria Francesca Egidi, Maria Fusaro
Renal diets for advanced chronic kidney disease (CKD) are structured to achieve a lower protein, phosphate and sodium intake, while supplying adequate energy. The aim of this nutritional intervention is to prevent or correct signs, symptoms and complications of renal insufficiency, delaying the start of dialysis and preserving nutritional status. This paper focuses on three additional aspects of renal diets that can play an important role in the management of CKD patients: the vitamin K1 and fiber content, and the alkalizing potential...
April 29, 2017: Nutrients
https://www.readbyqxmd.com/read/28464576/-laparoscopic-pancreaticoduodenectomy-with-a-novel-artery-first-and-uncinate-process-first-approach-through-treitz-ligament
#17
W T Gao, C H Xi, M Tu, X L Dai, F Guo, J M Chen, J S Wei, Z P Lu, J L Wu, K R Jiang, Y Miao
Objective: To explore the clinical effect of a novel artery first and uncinate process first approach for laparoscopic pancreaticoduodenectomy(LPD), emphasizing the left lateral and posterior dissection of uncinate process (UP) via Treitz ligament approach. Methods: From April to November 2016, 18 patients received LPD with a novel approach in Pancreas Center of the First Affiliated Hospital with Nanjing Medical University. All patients were diagnosed as pancreatic head or peri-ampulla tumor, without major vessel invasion nor distant metastasis...
May 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28464575/-laparoscopic-pancreaticoduodenectomy-a-report-of-233-cases-by-a-single-team
#18
W W Jin, X W Xu, Y P Mou, Y C Zhou, R C Zhang, J F Yan, J Y Zhou, C J Huang, C Lu
Objective: To summary the experience of 233 cases of laparoscopic pancreaticoduodenectomy (LPD) performed by a single surgical team. Methods: Data of patients undergoing LPD from September 2012 to October 2016 were reviewed. There were 145 males and 88 females with the mean age of(60.3±13.0)years old, ranging from 19 to 92 years old, and the mean body mass index of (22.8±3.5)kg/m(2,) ranging from 16.3 to 36.8 kg/m(2). There were 195 patients with clinical manifestation and 54 patients who had the history of abdominal surgery...
May 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28464571/-expert-consensus-of-laparoscopic-pancreaticoduodenectomy-postscript-of-operation-process-and-main-steps
#19
(no author information available yet)
Laparoscopic pancreaticoduodenectomy (LPD) is a minimally invasive approach for Whipple by total or assistant laparoscopic techniques. The results of feasibility, safety, short and long outcomes have slowly been gaining acceptance over the past decade. Aim to further adapt to the development trend, improve the safety and oncologic outcomes, promote the standardized development of LPD in China, four pancreas surgery groups in China wrote this LPD consensus. The consensus includes seven sections: operator request, indications and contraindications, preoperative preparation and anesthesia, equipment and instruments, positioning of patient and trocars, abdominal pressure, indications of conversion to laparotomy, postoperative observation and treatment...
May 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28464568/-developing-laparoscopic-pancreaticoduodenectomy-step-by-step
#20
T P Zhang, M Y Feng, Y P Zhao
Laparoscopic pancreaticoduodenectomy (LPD) is one of the most complicated operations in laparoscopic field.After been widely reported nowadays, LPD has been cautiously regarded as feasible and safe for radically resection.At present, several large pancreatic surgery centers in China have successively carried out this kind of surgery, with over one thousand cases in all.However, partly due to its complexity and steep learning curve, this procedure only remains limited to a few selected large pancreatic centers...
May 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
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