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https://www.readbyqxmd.com/read/29225245/oral-methotrexate-related-lymphoproliferative-disease-presenting-with-severe-osteonecrosis-of-the-jaw-a-case-report-and-literature-review
#1
Sachiko Furukawa, Kazunari Oobu, Masafumi Moriyama, Shintaro Kawano, Saori Sako, Jun-Nosuke Hayashida, Ryota Matsubara, Ken-Ichi Ogata, Tamotsu Kiyoshima, Seiji Nakamura
Long-term methotrexate (MTX) treatment can cause MTX-related lymphoproliferative disorder (MTX-LPD). We experienced a case of MTX-LPD that was associated with severe osteonecrosis of the jaw mimicking medication-related osteonecrosis of the jaw. The patient was an 81-year-old woman with rheumatoid arthritis (RA) who was treated with MTX and bisphosphonate. After 7 years, she was referred to our department for the assessment of giant ulcer and exposure of the alveolar bone of the left maxilla. Histopathological and immunological analyses confirmed a diagnosis of MTX-LPD...
December 8, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29218495/systemic-epstein-barr-virus-positive-t-cell-lymphoproliferative-disorders-of-childhood-with-fulminant-leukocytosis-and-tumor-lysis-a-case-report-with-autopsy-findings
#2
Sachie Wada, Takayuki Suzuki, Koichi Kitazume, Akira Fujita, Seiichiro Shimizu
Systemic Epstein-Barr virus (EBV)-positive T-cell lymphoproliferative disorders (T-LPD) of childhood is an extremely rare disease characterized by an aggressive clinical course and very poor prognosis. We report an adolescent male with systemic EBV-positive T-LPD of childhood after primary EBV infection, resulting in a fatal clinical course within 9 days, along with autopsy findings. A 19-year-old male without an immunocompromised status presented with an acute onset of high fever, and was hospitalized for persistent fever, vomiting and diarrhea on the 5th day from onset...
December 7, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/29213000/-a-methotrexate-associated-lympholiferative-disorder-patient-with-gastrointestinal-perforation
#3
Yasuo Aota, Tadahito Nonaka, Sei Kimura, Tadahiro Honda, Yuko Okuda, Tsubasa Watanabe, Keitaro Fujiwara, Tomohisa Yokoyama, Yukari Wakabayashi, Michio Sakurai, Akihiko Gotoh
A 70-year-old woman was diagnosed with chronic rheumatoid arthritis and treated with methotrexate and prednisolone. She visited our hospital to determine the cause of her continuous fatigue and fever for the past three weeks. She consumed no food orally and was provided antibiotics because free air was found on computed tomography (CT). Intraperitoneal small lymphadenopathy and swelling of both adrenal glands was also found on CT, and MTX-associated lymphoproliferative disorder (MTX-LPD) was suspected. Am adrenal gland biopsy showed diffuse large B-cell lymphoma (DLBCL) associated with MTX-LPD...
2017: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/29210292/the-role-of-lpd-nanoparticles-containing-recombinant-major-surface-glycoprotein-of-leishmania-rgp63-in-protection-against-leishmaniasis-in-murine-model
#4
Hengameh Firouzmand, Mehrnosh Sahranavard, Ali Badiee, Ali Khamesipour, Seyedeh Hoda Alavizadeh, Afshin Samiei, Dina Soroush, Masoumeh Tavassoti Kheiri, Fereidoun Mahboudi, Mahmoud Reza Jaafari
CONTEXT: Leishmaniasis is a major public health problem. Despite numerous attempts, yet there is no effective vaccine against human leishmaniasis, mainly due to a lack of an effective vaccine delivery system as well as adjuvant. OBJECTIVE(S): The aim of this study was to evaluate the ability of recombinant glycoprotein 63 (rgp63) as a model of Leishmania antigen, entrapped in liposome-polycation-DNA (LPD) complexes nanoparticles in inducing cell mediated immune (CMI) response and protecting against L...
December 6, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29208058/low-protein-diet-supplemented-with-ketoacids-delays-the-progression-of-diabetic-nephropathy-by-inhibiting-oxidative-stress-in-the-kkay-mice-model
#5
Dongmei Liu, Ming Wu, Lin Li, Xiang Gao, Bo Yang, Shuqin Mei, Lili Fu, Changlin Mei
Diabetic nephropathy (DN) is a major cause of chronic kidney disease. We aimed to investigate the effect of the low-protein diets (LPD) supplemented with ketoacids (LPD+KA) in KKAy mice, an early type 2 DN model. KKAy mice were treated with normal protein diet (NPD), LPD or LPD+KA from 12 to 24 weeks of age. A period of 12-week treatment with LPD significantly reduced albuminuria as compared with that observed after NPD treatment. Treatment with LPD+KA further reduced albuminuria as compared with that observed with LPD treatment alone...
December 6, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29196239/insulin-and-branched-chain-amino-acid-depletion-during-mouse-preimplantation-embryo-culture-programmes-body-weight-gain-and-raised-blood-pressure-during-early-postnatal-life
#6
Miguel A Velazquez, Bhavwanti Sheth, Stephanie J Smith, Judith J Eckert, Clive Osmond, Tom P Fleming
Mouse maternal low protein diet exclusively during preimplantation development (Emb-LPD) is sufficient to programme altered growth and cardiovascular dysfunction in offspring. Here, we use an in vitro model comprising preimplantation culture in medium depleted in insulin and branched-chain amino acids (BCAA), two proposed embryo programming inductive factors from Emb-LPD studies, to examine the consequences for blastocyst organisation and, after embryo transfer (ET), postnatal disease origin. Two-cell embryos were cultured to blastocyst stage in defined KSOM medium supplemented with four combinations of insulin and BCAA concentrations...
November 28, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29196156/leiomyomatosis-peritonealisis-disseminata-two-unusual-cases-with-literature-review
#7
L Gaichies, L Fabre-Monplaisir, R Fauvet, A Alves, A Mulliri
BACKGROUND: Leiomyomatosis peritonealis disseminata (LPD) is a rare benign disease characterized by numerous smooth muscle-like cell nodules disseminated among the abdominal cavity. The pathogenesis of LPD is not well known; one hypothesis, widely reported, is parasitic LPD (after uterine myoma surgery). The role of hormonal status has been raised without any evidence yet confirmed. Lesions of LPD can mimic carcinomatosis and lead to an unappropriated treatment. Total and spontaneous regression of the nodules is sometimes reported...
November 28, 2017: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29183703/a-comparison-of-outcomes-between-open-laparoscopic-and-robotic-pancreaticoduodenectomy
#8
Asha M Zimmerman, Dean G Roye, Kevin P Charpentier
BACKGROUND: The advantages and comparison of minimally invasive techniques for pancreaticoduodenectomies have not been fully explored using large national multicenter data. STUDY DESIGN: A retrospective review of NSQIP targeted data from 2014 to 2015 was performed. Demographics and outcomes were compared between open (OPD), laparoscopic (LPD) and robotic pancreaticoduodenectomies (RPD). RESULTS: Of 6827 pancreaticoduodenectomies, 6336 (92...
November 25, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29157109/comparison-of-patellar-tracking-according-to-different-angles-of-external-rotation-of-femoral-component-in-varus-knee-of-asians
#9
Jai Hyung Park, Seong-Il Bin, Jong-Min Kim, Bum-Sik Lee, Chang-Rack Lee, Jong-Min Kim, Yongun Cho
PURPOSE: Racial difference in the femoral geometry may exist. Asian femurs may be more externally rotated. If anatomical differences in distal femur had existed between Caucasians and Asians, the group with 5° external rotation of the femoral component should have shown better results than the group with 3° external rotation of the femoral component have. METHODS: 598 patients underwent total knee arthroplasty in our institution, among whom 83 patients (115 knees) who had postoperative computed tomography (CT) were studied retrospectively...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29146059/oral-lymphomatoid-papulosis-type-c-a-diagnostic-pitfall-often-confused-with-t-cell-lymphoma
#10
Ziv Schwartz, Morton Coleman, Jennifer P Toyohara, Paul D Freedman, Cynthia M Magro
Eosinophilic ulcer of the oral mucosa (EUOM) is a rare, benign, self-resolving lymphoproliferative disorder, which typically presents with asymptomatic to mildly tender ulcers. Histological findings of EUOM are characterized by a polymorphic infiltrate with many eosinophils often extending into the underlying muscle. Although this entity is well documented within the dental literature, it is not well known to physicians. The pathogenesis of the condition is unclear, although reports dating back to 1997 suggest that at least a subset of EUOM represents CD30 positive lymphoproliferative disorder (CD30+ LPD)...
December 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29112013/cancer-therapy-associated-lymphoproliferative-disorders-an-under-recognized-type-of-immunodeficiency-associated-lymphoproliferative-disorder
#11
Sergio Pina-Oviedo, Roberto N Miranda, L Jeffrey Medeiros
We describe the clinicopathologic features of 17 patients who had a hematologic malignancy of various types, were treated, and subsequently developed a lymphoproliferative disorder (LPD). There were 10 men and 7 women with a median age of 59 years (range, 36 to 83 y). The primary hematologic neoplasms included: 5 chronic lymphocytic leukemia/small lymphocytic lymphoma, 3 plasma cell myeloma, 2 acute monoblastic leukemia, and 1 case each of mixed-phenotype acute leukemia, chronic myeloid leukemia, splenic marginal zone lymphoma, follicular lymphoma, mantle cell lymphoma, T-cell prolymphocytic leukemia, and peripheral T-cell lymphoma...
November 3, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29107664/eruption-of-lymphocyte-recovery-with-atypical-lymphocytes-mimicking-a-primary-cutaneous-t-cell-lymphoma-a-series-of-12-patients
#12
Charlotte Hurabielle, Emilie Sbidian, Helmut Beltraminelli, Brigitte Bouchindhomme, Catherine Chassagne-Clément, Brigitte Balme, Céline Bossard, Marie-Hélène Delfau-Larue, Pierre Wolkenstein, Olivier Chosidow, Catherine Cordonnier, Andrea Toma, Cécile Pautas, Nicolas Ortonne
Eruption of lymphocyte recovery (ELR) may occur during bone marrow aplasia after chemotherapies. We reviewed the clinical and pathologic features of 12 patients (male/female: 7/5, median age: 61years) with an atypical ELR histologically mimicking a primary cutaneous T-cell lymphoma (CTCL) such as Sézary Syndrome or CD30+ T-cell lymphoproliferative disorder (LPD). All the patients displayed an erythematous maculopapular eruption on the trunk and the limbs, associated with fever. All but one had received a polychemotherapy for an acute myeloid leukemia (n=10) or an urothelial carcinoma (n=1) before the occurrence of the skin eruption...
October 28, 2017: Human Pathology
https://www.readbyqxmd.com/read/29105119/lymphoproliferative-disorders-with-concurrent-hhv8-and-ebv-infection-beyond-primary-effusion-lymphoma-and-germinotropic-lymphoproliferative-disorder
#13
Wei Wang, Rashmi Kanagal-Shamanna, Jeffrey L Medeiros
AIMS: Lymphoproliferative disorders (LPD) characterized by human herpesvirus 8 (HHV8) and Epstein-Barr virus (EBV) infection are rare and two entities are included in the World and Health Organization classification: primary effusion lymphoma (PEL) and germinotropic LPD. These two entities have very different clinicopathological presentations and prognosis. Here we describe two cases of HHV8-positive, EBV-positive lymphoma with clinicopathological features that are not consistent with either PEL or germinotropic LPD...
November 3, 2017: Histopathology
https://www.readbyqxmd.com/read/29099408/electrographic-and-clinical-natural-history-of-lateralized-periodic-discharges
#14
Vineet Punia, Ravi Vakani, Richard Burgess, Stephen Hantus
PURPOSE: The long-term electrographic features of lateralized periodic discharges (LPD) and their impact on clinical management are unclear. The authors investigated routine EEGs (rEEG) to analyze the delayed natural history of LPDs, and studied the clinical care of these patients. METHODS: After IRB approval, the prospectively maintained continuous EEG (cEEG) database was searched to identify patients fulfilling the following criteria: LPDs on cEEG, age ≥18 years, no epilepsy history, and rEEG completed within 1 to 12 months of hospital discharge...
October 26, 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/29099400/outcomes-of-a-multicenter-training-program-in-laparoscopic-pancreatoduodenectomy-laelaps-2
#15
Thijs de Rooij, Jony van Hilst, Baki Topal, Koop Bosscha, David J Brinkman, Michael F Gerhards, Ignace H de Hingh, Tom M Karsten, Daan J Lips, Misha D Luyer, Hendrik A Marsman, L Bengt van Rijssen, M Willemijn Steen, Olivier R Busch, Sebastiaan Festen, Marc G Besselink
OBJECTIVE: The aim of the study was to assess feasibility and outcomes of a multicenter training program in laparoscopic pancreatoduodenectomy (LPD). BACKGROUND: Whereas expert centers have reported promising outcomes of LPD, nationwide analyses have raised concerns on its safety, especially during the learning curve. Multicenter, structured LPD training programs reporting outcomes including the first procedures are lacking. No LPD had been performed in the Netherlands before this study...
November 2, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29084365/views-of-dermatopathologists-about-clonality-assays-in-the-diagnosis-of-cutaneous-t-cell-and-b-cell-lymphoproliferative-disorders
#16
REVIEW
Nneka Comfere, Uma Sundram, M Yadira Hurley, Brian Swick
BACKGROUND: Appropriate use criteria have been developed for many tests using expert judgment, evidence-based practice, and clinical experience. In this context, the opinions of practitioners about clonality assays in various clinical scenarios where cutaneous lymphoma is suspected are reported. METHODS: An Appropriate Use Criteria Task Force sponsored by the American Society of Dermatopathology (ASDP) synthesized clinical scenarios for cutaneous lymphoproliferative disorders (LPD)...
October 30, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29084057/evaluation-of-pd1-pdl1-expression-and-their-clinicopathologic-association-in-ebv-associated-lymphoproliferative-disorders-in-nonimmunosuppressed-patients
#17
Ling Guo, Juraj Bodo, Lisa Durkin, Eric D Hsi
Epstein-Barr virus (EBV)-associated lymphoproliferative disorders (LPD)/lymphomas in nonimmunosuppressed patients represent a unique entity and have been proposed to be related to immune senescence. Engagement of programmed cell death 1 (PD1) by its ligand programmed death ligand 1 (PDL1) inhibits T-cell activation, and leads to T-cell exhaustion. In clinical trials, therapeutic antibodies that block the PD1-PDL1 axis have shown promising therapeutic activity in certain types of lymphomas. Although PD1/PDL1 has been extensively studied in variety of lymphomas, there are few reports characterizing their expression in EBV-positive LPD...
October 27, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29069725/notch4-and-mhc-class-ii-polymorphisms-are-associated-with-hcv-related-benign-and-malignant-lymphoproliferative-diseases
#18
Laura Gragnani, Elisa Fognani, Valli De Re, Massimo Libra, Adriana Garozzo, Patrizio Caini, Guia Cerretelli, Andrea Giovannelli, Serena Lorini, Monica Monti, Silvia Bagnoli, Irene Piaceri, Anna Linda Zignego
Mixed cryoglobulinemia (MC), is a HCV-related, clinically benign, lymphoproliferative disorder (LPD) that may evolve into a non Hodgkin's lymphoma (NHL). Significant associations were found between two single nucleotide polymorphisms near NOTCH4 (rs2071286) and the HLA class II (rs9461776) genes and HCV-related MC syndrome (MCS). We analyzed NOTCH4 rs2071286 and HLA-II rs9461776 in 3 HCV-related LPD groups (asymptomatic MC, MCS, NHL) with HCV infection without lymphoproliferative disorders. We found a positive relationship between NOTCH4 rs207186 T minor allele frequency (MAF) and patients with HCV-related LPDs at risk of NHL (Chi-square test for trend = 14...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29067580/comparison-of-laparoscopic-to-open-pancreaticoduodenectomy-in-elderly-patients-with-pancreatic-adenocarcinoma
#19
Brandon C Chapman, Csaba Gajdos, Patrick Hosokawa, William Henderson, Alessandro Paniccia, Douglas M Overbey, Ana Gleisner, Richard D Schulick, Martin D McCarter, Barish H Edil
INTRODUCTION: The purpose of the study is to compare perioperative and survival outcomes in elderly patients undergoing laparoscopic pancreaticoduodenectomy (LPD) to those undergoing open pancreaticoduodenectomy (OPD). METHODS: Patients aged ≥ 75 years with pancreatic adenocarcinoma undergoing LPD or OPD were identified from the NCDB (2010-2013). Baseline characteristics and perioperative outcomes were compared using a χ (2) and Student's t test. The Kaplan-Meier method was used to generate survival curves, and differences were tested using a log-rank test...
October 24, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29060151/optimization-of-transcostal-phased-array-refocusing-using-sparse-semidefinite-relaxation-method
#20
Mohamed Almekkawy, Daniel McMahon, Hanan Alqarni, Jiayu He
Treating tumors in organs shadowed by the ribs is a challenge for high intensity focused ultrasound (HIFU). The ribs absorb energy from the ultrasound beams causing their temperature to rise, while also distorting the beams, and limiting the target heat deposition. Accordingly, it is necessary to devise focusing methods that address the difficulties presented by the ribs. In this paper, a new approach that reduces total power deposition on the region of interest (ROI) by removing transducer elements is introduced...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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