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Dongfang Shen, Min Li, Ying Zhou, Lixin Liang, Lu Zhang, Wangzikang Zhang, Mingsha Zhang, Yujun Pan
Background : Patients with Parkinson's disease (PD) commonly show spatially asymmetric behaviors, such as veering while attempting to walk in a straight line. While there is general agreement that the lateral motor dysfunction contributes to asymmetric behaviors in PD, it is dispute regarding whether the spatial perception is also biased. In addition, it is not clear whether PD impairs the speed of spatial information process, i.e., the efficiency of information process. Objectives : To assess the visuospatial representation and efficiency of spatial information processing in hemi-PD...
2018: Frontiers in Aging Neuroscience
Benedikt W Pelzer, Marina Arendt, Susanne Moebus, Lewin Eisele, Karl-Heinz Jöckel, Ulrich Dührsen, Jan Dürig
We determined the 10-year progression rate of light chain monoclonal gammopathy of undetermined significance (LCMGUS) and investigated potential associations with cancer utilizing the German population-based Heinz Nixdorf Recall Study. The Heinz Nixdorf Recall Study comprises 4814 men and women aged 45-75 years. Serum samples from baseline (2000-2003) and five-year (2006-2008) and 10-year (2011-2015) follow-up examinations were screened for monoclonal free light chains (FLC). LCMGUS was defined as abnormal FLC ratio, increase of involved FLC with complete loss of immunoglobulin heavy chain, and absence of a history of lymphoproliferative disease (LPD)...
April 9, 2018: Annals of Hematology
Cristina Mozo Mulero, Alfonso Sáez, Jesús Iniesta, Vicente Montiel
The electrocatalytic hydrogenation of benzophenone was performed at room temperature and atmospheric pressure using a polymer electrolyte membrane electrochemical reactor (PEMER). Palladium (Pd) nanoparticles were synthesised and supported on a carbonaceous matrix (Pd/C) with a 28 wt % of Pd with respect to carbon material. Pd/C was characterised by transmission electron microscopy (TEM), and thermogravimetric analysis (TGA). Cathodes were prepared using Pd electrocatalytic loadings (LPd ) of 0.2 and 0.02 mg cm-2 ...
2018: Beilstein Journal of Organic Chemistry
Yunqiang Cai, Pan Gao, Yongbin Li, Xin Wang, Bing Peng
BACKGROUND: The en bloc resection of the superior mesenteric or portal vein with concomitant venous reconstruction may be required in patients with borderline resectable pancreatic cancer. However, performing laparoscopic pancreaticoduodenectomy (LPD) with major venous resection and reconstruction is technically challenging. Herein, we introduced a safe and feasible technique to perform LPD with major venous resection. METHODS: Over the period of November 2015 to November 2016, 18 patients underwent laparoscopic pancreaticoduodenectomy with major venous resection and reconstruction using the anterior superior mesenteric artery (SMA)-first approach at our institution...
March 30, 2018: Surgical Endoscopy
Molly Hardesty-Moore, Stefanie Deinet, Robin Freeman, Georgia C Titcomb, Erin M Dillon, Keenan Stears, Maggie Klope, An Bui, Devyn Orr, Hillary S Young, Ana Miller-Ter Kuile, Lacey F Hughey, Douglas J McCauley
Recent increases in human disturbance pose significant threats to migratory species using collective movement strategies. Key threats to migrants may differ depending on behavioural traits (e.g. collective navigation), taxonomy and the environmental system (i.e. freshwater, marine or terrestrial) associated with migration. We quantitatively assess how collective navigation, taxonomic membership and environmental system impact species' vulnerability by (i) evaluating population change in migratory and non-migratory bird, mammal and fish species using the Living Planet Database (LPD), (ii) analysing the role of collective navigation and environmental system on migrant extinction risk using International Union for Conservation of Nature (IUCN) classifications and (iii) compiling literature on geographical range change of migratory species...
May 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Xiaofei Jiang, Huifang Zhou, Mingqing Shi, Boru Zhou, Bei Liu, Yizhen Yuan, Jinjun Shan, Jianya Xu, Tong Xie
Luteal phase defects (LPD) are an important etiology of infertility which has increased in recent years. Studies have shown that bu-shen-zhu-yun decoction (BSZY-D) can lower the expression of estrogen receptor and progesterone receptor, in rats endometrium of embryonic implantation period, which upregulated by mifepristone, and improve uterine receptivity. The aim of present study was to determine the effect of BSZY-D on the synthesis and secretion of gonadotropic hormones in the anterior pituitary cells of rats...
March 23, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Miguel Cainzos-Achirica, Cristina Varas-Lorenzo, Anton Pottegård, Joelle Asmar, Estel Plana, Lotte Rasmussen, Geoffray Bizouard, Joan Forns, Maja Hellfritzsch, Kristina Zint, Susana Perez-Gutthann, Manel Pladevall-Vila
PURPOSE: To report and discuss estimated prevalence of potential off-label use and associated methodological challenges using a case study of dabigatran. METHODS: Observational, cross-sectional study using 3 databases with different types of clinical information available: Cegedim Strategic Data Longitudinal Patient Database (CSD-LPD), France (cardiologist panel, n = 1706; general practitioner panel, n = 2813; primary care data); National Health Databases, Denmark (n = 28 619; hospital episodes and dispensed ambulatory medications); and Clinical Practice Research Datalink (CPRD), UK (linkable to Hospital Episode Statistics [HES], n = 2150; not linkable, n = 1285; primary care data plus hospital data for HES-linkable patients)...
March 23, 2018: Pharmacoepidemiology and Drug Safety
Daejong Yang, Jaehwan Lee, Donghwan Kim, Incheol Cho, Jong G Ok, Inkyu Park
We propose ZnO nanowire and TiO2 nanotube based light sensors on flexible polymer substrates fabricated by localized hydrothermal synthesis and liquid phase deposition (LPD). This method realized simple and cost-effective in-situ synthesis and integration of ZnO and TiO2 one dimensional nanomaterials. The fabricated sensor devices with ZnO nanowires and TiO2 nanotubes show very high sensitivity and quick response to the ultraviolet (UV) and ambient light, respectively. In addition, our direct synthesis and integration method made mechanical robustness under external loading such as static and cyclic bending because of both the strong bonding between nanomaterial and electrode...
March 14, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Nicholas Yock Teck Soh, Nan Zun Teo, Carrie Jen Hsi Tan, Shivani Rajaraman, Marianne Tsang, Calvin Jian Ming Ong, Ramesh Wijaya
BACKGROUND: It is unclear if location of disease matters in perforated diverticulitis. Management guidelines for perforated diverticulitis currently do not make a distinction between right perforated diverticulitis (RPD) and left perforated diverticulitis (LPD). We aim to compare disease presentation and management outcomes between RPD and LPD. METHODS: This was a 10-year retrospective comparative cohort study of 99 patients with acute perforated diverticulitis between 2004 and 2013 in a single institution...
March 12, 2018: International Journal of Colorectal Disease
Guang-Ying Zhang, Hong-Xia Zhu, En-Miao Li, Hao Shi, Wei Liu, Lei Zheng, Zheng-Wu Bai, Hong-Yu Ding
Objective: To evaluate the correlation between the injury patterns of the medial patellofemoral ligament (MPFL) on magnetic resonance imaging in an acute first-time lateral patellar dislocation (LPD) and incidence of a second-time LPD. Materials and Methods: Magnetic resonance images were prospectively analyzed in 147 patients after an acute first-time LPD with identical nonoperative management. The injury patterns of MPFL in acute first-time LPDs were grouped by location and severity for the analysis of the incidence of second-time LPD in a 5-year follow-up...
March 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
Stefan D Dojcinov, Falko Fend, Leticia Quintanilla-Martinez
The contribution of Epstein-Barr virus (EBV) to the development of specific types of benign lymphoproliferations and malignant lymphomas has been extensively studied since the discovery of the virus over the last 50 years. The importance and better understanding of the EBV-associated lymphoproliferative disorders (LPD) of B, T or natural killer (NK) cell type has resulted in the recognition of new entities like EBV+ mucocutaneous ulcer or the addition of chronic active EBV (CAEBV) infection in the revised 2016 World Health Organization (WHO) lymphoma classification...
March 7, 2018: Pathogens
Munehiro Kitada, Yoshio Ogura, Taeko Suzuki, Itaru Monno, Keizo Kanasaki, Ai Watanabe, Daisuke Koya
Background: The objective of this study is to investigate the effects of a low-protein diet (LPD) starting from a young age on diabetic status and renal injury in a rat model of type 2 diabetes and obesity. Methods: Diabetic male Wistar fatty ( fa/fa ) rats (WFRs) were fed a standard diet (23.84% protein) or an LPD (5.77% protein) for 24 weeks beginning at 6 weeks of age. We investigated the effects of the LPD on total body weight (BW); fat weight (FW); lower-limb muscle weight (MW); several measures of diabetic status, including fasting/random glucose levels, HOMA-IR and the IPITT; and renal injuries, including renal hypertrophy, albuminuria and histological changes...
2018: Nutrition & Metabolism
Areej Alkhaldy, Christine A Edwards, Emilie Combet
PURPOSE: To investigate whether age influences colonic polyphenol metabolism. METHODS: Healthy participants, younger (n = 8; 23-43 years) and older (n = 13; 51-76 years), followed a 3-day low-polyphenol diet (LPD) and a 3-day high-polyphenol diet (HPD). Urinary phenolic acids (PA), short chain fatty acids (SCFA), pH and gas were monitored, alongside selected colonic bacteria. Human faecal in vitro fermentations of rutin with or without raftiline were used to evaluate the gut microbiota capacity in a subset of both groups...
February 27, 2018: European Journal of Nutrition
Girolamo Ranieri, Ilaria Marech, Mariangela Porcelli, Francesco Giotta, Gennaro Palmiotti, Giuseppe Laricchia, Vito Fazio, Cosmo Damiano Gadaleta
About half of patients with metastatic breast cancer (mBC) have unresectable liver metastases (LMs) or liver-predominant disease (LPD). Unfortunately systemic chemotherapy has limited tumor response due to LMs are supplied by hepatic artery. Hepatic intra-arterial (HAI) have antitumor activity in pretreated patients with LMs. Here we report the case of a 55-year-old woman affected by BCLPD and heavily pretreated. LMs responded to treatment based on HAI with 5-fluorouracil and nab-paclitaxel systemic chemotherapy, and they completely disappeared on a CT-scan...
January 30, 2018: Oncotarget
Bernhard Josef Eigl, Kim Chi, Dongsheng Tu, Sebastien J Hotte, Eric Winquist, Christopher M Booth, Christina Canil, Kylea Potvin, Richard Gregg, Scott North, Muhammad Zulfiqar, Susan Ellard, Joseph Dean Ruether, Lyly Le, A Saranya Kakumanu, Mohammad Salim, Alison L Allan, Harriet Feilotter, Ashley Theis, Lesley Seymour
Background: Pelareorep is an oncolytic virus with activity in many cancers including prostate. It has in vitro synergism with microtubule-targeted agents. We undertook a clinical trial evaluating pelareorep in mCRPC patients receiving docetaxel. Patients and Methods: In this randomized, open-label phase II study, patients received docetaxel 75mg/m2 on day 1 of a 21-day cycle and prednisone 5mg twice daily, in combination with pelareorep (arm A) or alone (arm B)...
January 30, 2018: Oncotarget
Yuichi Nagakawa, Yuichi Hosokawa, Yatsuka Sahara, Chie Takishita, Yosuke Hijikata, Hiroaki Osakabe, Tetsushi Nakajima, Tomoki Shirota, Kenji Katsumata, Masafumi Nakamura, Akihiko Tsuchida
BACKGROUND: Although the artery-first approach is widely used in open pancreaticoduodenectomy, it is difficult to laparoscopically expose the origin of the inferior pancreaticoduodenal artery (IPDA) from the left side of the superior mesenteric artery (SMA). By contrast, damaging the inferior pancreaticoduodenal veins (IPDVs) is possible when approaching the IPDA from the right side of the SMA. To facilitate the artery-first approach in laparoscopic pancreaticoduodenectomy (LPD), we focused on the proximal-dorsal jejunal vein (PDJV) that branched from the superior mesenteric vein (SMV) dorsal side and drained the IPDVs...
February 26, 2018: Surgical Endoscopy
Juliana Saraiva Anjos, Ludmila F M F Cardozo, Marta Esgalhado, Bengt Lindholm, Peter Stenvinkel, Denis Fouque, Denise Mafra
Oxidative stress and inflammation are common findings in chronic kidney disease (CKD) patients, and they are directly linked to clinical outcomes such as protein energy wasting and cardiovascular disease. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is the master regulator of antioxidant genes, regulating the expression of detoxifying enzymes of phase II and antioxidant responses. Furthermore, Nrf2 can also regulate anti-inflammatory cellular responses, by inhibiting nuclear factor kappa B activity (transcription factor that promotes inflammation)...
February 13, 2018: Journal of Renal Nutrition
Ruwei Ou, Yanbing Hou, Wei Song, Qianqian Wei, Yongping Chen, Bei Cao, Xiaoqin Yuan, Huifang Shang
Background The number of Parkinson's disease (PD) patients with disease duration of more than 20 years (long disease duration PD, LPD) is on the rise. Objectives This study aims to describe the clinical profiles and the quality of life (QoL) of LPD patients from a cohort of the Chinese population. Methods We compared 71 LPD subjects to 60 PD patients who died less than 20 years after the onset of PD (control PD, CPD). A regression model was constructed to assess the determinants for 20 years survival and the QoL of LPD patients...
April 2018: Neurological Research
Limin Zou, Su Zhang, Baokai Wang, Jiubin Tan
A new scheme of super-resolution optical fluctuation imaging (SOFI) is proposed to broaden its application in the high-order case by separating the elimination of shot noise from the computation of cumulant, applying the low-pass denoising (LPD) operator to SOFI. The high-order cumulants are derived from a basic recursion of moments with the suppression of shot noise by the LPD on raw data. SOFI based on LPD (LPD-SOFI) demonstrates a 10.6-fold lateral resolution enhancement with the cumulant order of the 16th and a seven-fold three-dimensional resolution enhancement with the cumulant order of the 10th in experiments performed on a sparse sample of quantum dots...
February 15, 2018: Optics Letters
Ana Paula Black, Juliana S Anjos, Ludmila Cardozo, Flávia L Carmo, Carla J Dolenga, Lia S Nakao, Dennis de Carvalho Ferreira, Alexandre Rosado, José Carlos Carraro Eduardo, Denise Mafra
OBJECTIVES: To evaluate the effects of low-protein diet (LPD) on uremic toxins and the gut microbiota profile in nondialysis chronic kidney disease (CKD) patients. DESIGN AND METHODS: Longitudinal study with 30 nondialysis CKD patients (stage 3-4) undergoing LPD for 6 months. Adherence to the diet was evaluated based on the calculation of protein equivalent of nitrogen appearance from the 24-hour urine analysis. Good adherence to LPD was considered when protein intake was from 90% to 110% of the prescribed amount (0...
February 10, 2018: Journal of Renal Nutrition
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