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https://www.readbyqxmd.com/read/27899104/the-magnitude-of-nephron-number-reduction-mediates-intrauterine-growth-restriction-induced-long-term-chronic-renal-disease-in-the-rat-a-comparative-study-in-two-experimental-models
#1
Farid Boubred, Laurent Daniel, Christophe Buffat, Michel Tsimaratos, Charles Oliver, Martine Lelièvre-Pégorier, Umberto Simeoni
BACKGROUND: Intrauterine growth restriction (IUGR) is a risk factor for hypertension (HT) and chronic renal disease (CRD). A reduction in the nephron number is proposed to be the underlying mechanism; however, the mechanism is debated. The aim of this study was to demonstrate that IUGR-induced HT and CRD are linked to the magnitude of nephron number reduction, independently on its cause. METHODS: Systolic blood pressure (SBP), glomerular filtration rate (GFR), proteinuria, nephron number, and glomerular sclerosis were compared between IUGR offspring prenatally exposed to a maternal low-protein diet (9% casein; LPD offspring) or maternal administration of betamethasone (from E17 to E19; BET offspring) and offspring with a normal birth weight (NBW offspring)...
November 30, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27898000/patient-survival-and-costs-on-moderately-restricted-low-protein-diets-in-advanced-ckd-equivalent-survival-at-lower-costs
#2
Giorgina Barbara Piccoli, Marta Nazha, Irene Capizzi, Federica Neve Vigotti, Elena Mongilardi, Marilisa Bilocati, Paolo Avagnina, Elisabetta Versino
The indications for delaying the start of dialysis have revived interest in low-protein diets (LPDs). In this observational prospective study, we enrolled all patients with chronic kidney disease (CKD) who followed a moderately restricted LPD in 2007-2015 in a nephrology unit in Italy: 449 patients, 847 years of observation. At the start of the diet, the median glomerular filtration rate (GFR) was 20 mL/min, the median age was 70, the median Charlson Index was 7. Standardized mortality rates for the "on-diet" population were significantly lower than for patients on dialysis (United States Renal Data System (USRDS): 0...
November 25, 2016: Nutrients
https://www.readbyqxmd.com/read/27864344/targeting-tumor-associated-fibroblasts-for-therapeutic-delivery-in-desmoplastic-tumors
#3
Lei Miao, Qi Liu, C Michael Lin, Cong Luo, Yuhua Wang, Lina Liu, Weiyan Yin, Shihao Hu, William Y Kim, Leaf Huang
The off-target distribution of anticancer nanoparticles (NP) to fibroblasts creates a barrier to the effective treatment of desmoplastic tumors. However, we hypothesized that this NP detriment might be exploited to target the expression of secreted cytotoxic proteins from cancer-associated fibroblasts (CAF) as an anticancer strategy. In addressing this hypothesis, plasmids encoding the secretable TNF-related factor sTRAIL were loaded into lipid-coated protamine DNA complexes (LPD) and administered by infusion in a murine xenograft model of human desmoplastic bladder carcinoma...
November 18, 2016: Cancer Research
https://www.readbyqxmd.com/read/27846761/prognostic-factors-of-methotrexate-associated-lymphoproliferative-disorders-associated-with-rheumatoid-arthritis-and-plausible-application-of-biological-agents
#4
Takayuki Katsuyama, Ken-Ei Sada, Minglu Yan, Sonia Zeggar, Sumie Hiramatsu, Yoshia Miyawaki, Keiji Ohashi, Michiko Morishita, Haruki Watanabe, Eri Katsuyama, Mariko Takano-Narazaki, Noriko Toyota-Tatebe, Katsue Sunahori-Watanabe, Tomoko Kawabata, Kohei Miyake, Toru Kiguchi, Jun Wada
OBJECTIVES: To determine prognostic factors of methotrexate-associated lymphoproliferative disorder (MTX-LPD) and evaluate the efficacy and safety of biological therapy in rheumatoid arthritis (RA) complicated with MTX-LPD. METHODS: Thirty RA patients who developed MTX-LPD were investigated in this study. We compared the clinical and laboratory parameters of patients who achieved regression of LPD by MTX withdrawal with those who required chemotherapy and evaluated the clinical course of RA after LPD development...
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27830722/comprehensive-polymerase-chain-reaction-assay-for-detection-of-pathogenic-dna-in-lymphoproliferative-disorders-of-the-ocular-adnexa
#5
Yoshihiko Usui, Narsing A Rao, Hiroshi Takase, Kinya Tsubota, Kazuhiko Umazume, Daniel Diaz-Aguilar, Takeshi Kezuka, Manabu Mochizuki, Hiroshi Goto, Sunao Sugita
Infectious agents have been identified as a major cause of specific types of human cancers worldwide. Several microorganisms have been identified as potential aggravators of ocular adnexal neoplasms; however, given the rarity of these neoplasms, large epidemiological studies are difficult to coordinate. This study aimed to conduct an exhaustive search for pathogenic DNA in lymphoproliferative disorders (LPD) of the ocular adnexa in a total of 70 patients who were diagnosed with LPD of the ocular adnexa between 2008 and 2013...
November 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27815783/laparoscopic-pancreatoduodenectomy-current-status-and-future-directions
#6
REVIEW
Alessandro Coppola, John A Stauffer, Horacio J Asbun
In recent years, laparoscopic pancreatoduodenectomy (LPD) has been gaining a favorable position in the field of pancreatic surgery. However, its role still remains unclear. This review investigates the current status of LPD in high-volume centers. A literature search was conducted in PubMed, and only papers written in English containing more than 30 cases of LPD were selected. Papers with "hybrid" or robotic technique were not included in the analysis. Out of a total of 728 LPD publications, 7 publications matched the review criteria...
September 2016: Updates in Surgery
https://www.readbyqxmd.com/read/27804043/laparoscopic-adapted-blumgart-pancreaticojejunostomy-in-laparoscopic-pancreaticoduodenectomy
#7
Ignasi Poves, Olga Morató, Fernando Burdío, Luís Grande
BACKGROUND: Laparoscopic pancreaticoduodenectomy (LPD) is a complex procedure that is becoming increasingly popular among surgeons. Postoperative pancreatic fistula (POPF) remains the most feared specific complication in reconstruction after PD. The Blumgart anastomosis (BA) has been established as one of the safest anastomosis for pancreas remnant reconstruction, with low rates of POPF and postoperative complications. The procedure for performing this anastomosis by laparoscopic approach has not been reported to date...
November 1, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27801685/dietary-protein-intake-and-chronic-kidney-disease
#8
Gang Jee Ko, Yoshitsugu Obi, Amanda R Tortorici, Kamyar Kalantar-Zadeh
PURPOSE OF REVIEW: High-protein intake may lead to increased intraglomerular pressure and glomerular hyperfiltration. This can cause damage to glomerular structure leading to or aggravating chronic kidney disease (CKD). Hence, a low-protein diet (LPD) of 0.6-0.8 g/kg/day is often recommended for the management of CKD. We reviewed the effect of protein intake on incidence and progression of CKD and the role of LPD in the CKD management. RECENT FINDINGS: Actual dietary protein consumption in CKD patients remains substantially higher than the recommendations for LPD...
January 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/27799148/deregulated-expression-of-hdac9-in-b-cells-promotes-development-of-lymphoproliferative-disease-and-lymphoma
#9
V S Gil, G Bhagat, L Howell, J Zhang, C H Kim, S Stengel, F Vega, A Zelent, K Petrie
Histone Deacetylase 9 (HDAC9) is expressed in B-cells and its overexpression has been observed in B-lymphoproliferative disorders and B-cell non-Hodgkin lymphomas (B-NHL). We examined HDAC9 protein expression and copy number alterations in primary B-NHL samples, identifying high HDAC9 expression among various lymphoma entities and HDAC9 copy number gains in 50% of diffuse large B-cell lymphoma (DLBCL). To study the role of HDAC9 in lymphomagenesis we generated a genetically engineered mouse (GEM) model that constitutively expressed an HDAC9 transgene throughout B-cell development under the control of the immunoglobulin heavy chain (IgH) enhancer (Eμ)...
October 28, 2016: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/27775639/low-protein-diets-in-diabetic-chronic-kidney-disease-ckd-patients-are-they-feasible-and-worth-the-effort
#10
Giorgina B Piccoli, Federica Ventrella, Irene Capizzi, Federica N Vigotti, Elena Mongilardi, Giorgio Grassi, Valentina Loi, Gianfranca Cabiddu, Paolo Avagnina, Elisabetta Versino
Low-protein diets (LPDs) are often considered as contraindicated in diabetic patients, and are seldom studied. The aim of this observational study was to provide new data on this issue. It involved 149 diabetic and 300 non-diabetic patients who followed a LPD, with a personalized approach aimed at moderate protein restriction (0.6 g/day). Survival analysis was performed according to Kaplan-Meier, and multivariate analysis with Cox model. Diabetic versus non-diabetic patients were of similar age (median 70 years) and creatinine levels at the start of the diet (2...
October 21, 2016: Nutrients
https://www.readbyqxmd.com/read/27769183/role-of-low-protein-diet-in-management-of-different-stages-of-chronic-kidney-disease-practical-aspects
#11
Bharat V Shah, Zamurrud M Patel
BACKGROUND: Chronic kidney disease (CKD) is a worldwide public health problem and more so in India. With limited availability and high cost of therapy, barely 10 % of patients with incident end stage renal disease (ESRD) cases get treatment in India. Therefore, all possible efforts should be made to retard progression of CKD. This article reviews the role of low protein diet (LPD) in management of CKD subjects and suggests how to apply it in clinical practice. DISCUSSION: The role of LPD in retarding progression of CKD is well established in animal experimental studies...
October 21, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27753426/low-protein-diet-supplemented-with-ketoacids-ameliorates-proteinuria-in-3-4-nephrectomised-rats-by-directly-inhibiting-the-intrarenal-renin-angiotensin-system
#12
Jia-Ying Zhang, Ying Yin, Li Ni, Quan Long, Li You, Qian Zhang, Shan-Yan Lin, Jing Chen
Low-protein diet plus ketoacids (LPD+KA) has been reported to decrease proteinuria in patients with chronic kidney diseases (CKD). However, the mechanisms have not been clarified. As over-activation of intrarenal renin-angiotensin system (RAS) has been shown to play a key role in the progression of CKD, the current study was performed to investigate the direct effects of LPD+KA on intrarenal RAS, independently of renal haemodynamics. In this study, 3/4 subtotal renal ablated rats were fed 18 % normal-protein diet (Nx-NPD), 6 % low-protein diet (Nx-LPD) or 5 % low-protein diet plus 1 % ketoacids (Nx-LPD+KA) for 12 weeks...
October 18, 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27746047/ribonuclease-mediated-control-of-body-fat
#13
Cornelia Habacher, Yanwu Guo, Richard Venz, Pooja Kumari, Anca Neagu, Dimos Gaidatzis, Eva B Harvald, Nils J Færgeman, Heinz Gut, Rafal Ciosk
Obesity is a global health issue, arousing interest in molecular mechanisms controlling fat. Transcriptional regulation of fat has received much attention, and key transcription factors involved in lipid metabolism, such as SBP-1/SREBP, LPD-2/C/EBP, and MDT-15, are conserved from nematodes to mammals. However, there is a growing awareness that lipid metabolism can also be controlled by post-transcriptional mechanisms. Here, we show that the Caenorhabditis elegans RNase, REGE-1, related to MCPIP1/Zc3h12a/Regnase-1, a key regulator of mammalian innate immunity, promotes accumulation of body fat...
October 7, 2016: Developmental Cell
https://www.readbyqxmd.com/read/27739291/effects-of-low-nano2-and-nacl-concentrations-on-listeria-monocytogenes-growth-in-emulsion-type-sausage
#14
Jeeyeon Lee, Eunji Gwak, Heeyoung Lee, Jimyeong Ha, Soomin Lee, Sejeong Kim, Mi-Hwa Oh, Beom-Young Park, Kyoung-Hee Choi, Yohan Yoon
Objective: The objective of this study was to evaluate the effect of combinations of NaNO2 and NaCl concentrations on Listeria monocytogenes growth in emulsion-type sausage. Methods: Sausages formulated with different combinations of NaNO2 (0 and 10 ppm) and NaCl (1.0%, 1.25% and 1.5%) were inoculated with a five-strain L. monocytogenes mixture, and stored at 4oC, 10oC or 15oC, under aerobic or vacuum conditions. L. monocytogenes cell counts were measured at appropriate intervals, and kinetic parameters such as growth rate and lag phase duration (LPD) were calculated using the modified Gompertz model...
October 5, 2016: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/27688035/current-status-of-laparoscopic-pancreaticoduodenectomy-and-pancreatectomy
#15
Akira Umemura, Hiroyuki Nitta, Takeshi Takahara, Yasushi Hasegawa, Akira Sasaki
This review describes the recent advances in, and current status of, minimally invasive pancreatic surgery (MIPS). Typical MIPS procedures are laparoscopic pancreaticoduodenectomy (LPD), laparoscopic distal pancreatectomy (LDP), laparoscopic central pancreatectomy (LCP), and laparoscopic total pancreatectomy (LTP). Some retrospective studies comparing LPD or LDP and open procedures have demonstrated the safety and feasibility as well as the intraoperative outcomes and postoperative recovery of these procedures...
September 26, 2016: Asian Journal of Surgery
https://www.readbyqxmd.com/read/27683011/compliance-illiteracy-and-low-protein-diet-multiple-challenges-in-ckd-and-a-case-of-self-empowerment
#16
Stefania Maxia, Valentina Loi, Irene Capizzi, Giorgina Barbara Piccoli, Gianfranca Cabiddu, Antonello Pani
BACKGROUND: Low-protein diets (LPD) are an important means of delaying the need for dialysis and attaining a stable metabolic balance in chronic kidney disease (CKD). Many authors consider a low educational level and illiteracy to be adverse features for a good dietary compliance. CASE PRESENTATION: We report the case of a 77-year old woman, illiterate, affected by advanced CKD (stage 4 according to KDIGO guidelines). She was initially ashamed of her problem and did not declare it, leading to an overzealous reduction in protein intake...
September 29, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27667981/proteomics-analysis-of-three-different-strains-of-mycobacterium-tuberculosis-under-in-vitro-hypoxia-and-evaluation-of-hypoxia-associated-antigen-s-specific-memory-t-cells-in-healthy-household-contacts
#17
Santhi Devasundaram, Akilandeswari Gopalan, Sulochana D Das, Alamelu Raja
In vitro mimicking conditions are thought to reflect the environment experienced by Mycobacterium tuberculosis inside the host granuloma. The majority of in vitro dormancy experimental models use laboratory-adapted strains H37Rv or Erdman instead of prevalent clinical strains involved during disease outbreaks. Thus, we included the most prevalent clinical strains (S7 and S10) of M. tuberculosis from south India in addition to H37Rv for our in vitro oxygen depletion (hypoxia) experimental model. Cytosolic proteins were prepared from hypoxic cultures, resolved by two-dimensional electrophoresis and protein spots were characterized by mass spectrometry...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27663236/the-effect-of-lateralization-of-motor-onset-and-emotional-recognition-in-pd-patients-using-eeg
#18
R Yuvaraj, M Murugappan, R Palaniappan
The objective of this research was to investigate the relationship between emotion recognition and lateralization of motor onset in Parkinson's disease (PD) patients using electroencephalogram (EEG) signals. The subject pool consisted of twenty PD patients [ten with predominantly left-sided (LPD) and ten with predominantly right-sided (RPD) motor symptoms] and 20 healthy controls (HC) that were matched for age and gender. Multimodal stimuli were used to evoke simple emotions, such as happiness, sadness, fear, anger, surprise, and disgust...
September 23, 2016: Brain Topography
https://www.readbyqxmd.com/read/27662324/coexistence-of-lymphoproliferative-and-myeloproliferative-neoplasms-with-simultaneous-calr-and-jak2-v617f-mutations
#19
Hai-Su Yang
BACKGROUND: Hematopoietic malignancies are a group of blood cell disorders characterized by abnormal hematopoietic proliferation. OBJECTIVE: The identification of specific clinicopathologic characteristics and tumor-related gene status provides critical information on potential therapeutic targets. METHODS: The specimens were tested with immunohistochemistry, flow cytometry, RT-PCR and fragment analysis. RESULTS: In this study, a patient with a long history of tobacco use was reported with a diagnosis of simultaneous low-grade B-cell lymphoproliferative disorder (LPD) and myeloproliferative neoplasm (MPN)...
September 18, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27631318/the-surgical-outcomes-of-robot-assisted-laparoscopic-pancreaticoduodenectomy-versus-laparoscopic-pancreaticoduodenectomy-for-periampullary-neoplasms-a-comparative-study-of-a-single-center
#20
Rong Liu, Tao Zhang, Zhi-Ming Zhao, Xiang-Long Tan, Guo-Dong Zhao, Xuan Zhang, Yong Xu
BACKGROUND: Pancreaticoduodenectomy (PD) is a difficult and complex operation. The introduction of robotics has opened up new angles in pancreatic surgery. This study aims to assess the surgical outcomes of robot-assisted laparoscopic pancreaticoduodenectomy relative to its laparoscopic counterpart. METHODS: A retrospective study was designed to compare the surgical outcomes of 27 robot-assisted laparoscopic pancreaticoduodenectomy (RPD) and 25 laparoscopic pancreaticoduodenectomy (LPD)...
September 8, 2016: Surgical Endoscopy
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