keyword
https://read.qxmd.com/read/36934673/effect-of-triple-therapy-with-low-dose-total-body-irradiation-and-hypo-fractionated-radiation-plus-anti-programmed-cell-death-protein-1-blockade-on-abscopal-antitumor-immune-responses-in-breast-cancer
#21
JOURNAL ARTICLE
Shuya Liu, Yin Liao, Yao Chen, Hanshan Yang, Yuru Hu, Zhuo Chen, Shaozhi Fu, Jingbo Wu
Immunostimulatory effects of radiotherapy can be synergistically augmented with immune checkpoint blockade to act both on irradiated tumor lesions and distant, non-irradiated tumor sites. Our hypothesis was that low-dose total body irradiation (L-TBI) combined with hypo-fractionated radiotherapy (H-RT) and anti-programmed cell death protein 1 (aPD-1) checkpoint blockade would enhance the systemic immune response. We tested the efficacy of this triple therapy (L-TBI + H-RT + aPD-1) in BALB/c mice with bilateral breast cancer xenografts...
April 2023: International Immunopharmacology
https://read.qxmd.com/read/36693842/in-situ-cryo-immune-engineering-of-tumor-microenvironment-with-cold-responsive-nanotechnology-for-cancer-immunotherapy
#22
JOURNAL ARTICLE
Wenquan Ou, Samantha Stewart, Alisa White, Elyahb A Kwizera, Jiangsheng Xu, Yuanzhang Fang, James G Shamul, Changqing Xie, Suliat Nurudeen, Nikki P Tirada, Xiongbin Lu, Katherine H R Tkaczuk, Xiaoming He
Cancer immunotherapy that deploys the host's immune system to recognize and attack tumors, is a promising strategy for cancer treatment. However, its efficacy is greatly restricted by the immunosuppressive (i.e., immunologically cold) tumor microenvironment (TME). Here, we report an in-situ cryo-immune engineering (ICIE) strategy for turning the TME from immunologically "cold" into "hot". In particular, after the ICIE treatment, the ratio of the CD8+ cytotoxic T cells to the immunosuppressive regulatory T cells is increased by more than 100 times in not only the primary tumors with cryosurgery but also distant tumors without freezing...
January 24, 2023: Nature Communications
https://read.qxmd.com/read/36631161/intratumoral-bo-112-in-combination-with-radiotherapy-synergizes-to-achieve-cd8-t-cell-mediated-local-tumor-control
#23
JOURNAL ARTICLE
Maria E Rodriguez-Ruiz, Irantzu Serrano-Mendioroz, Eneko Garate-Soraluze, Paloma Sánchez-Mateos, Celia Barrio-Alonso, Inmaculada Rodríguez López, Victor Diaz Pascual, Leire Arbea Moreno, Maite Alvarez, Miguel F Sanmamed, Jose Luis Perez-Gracia, Helena Escuin-Ordinas, Marisol Quintero, Ignacio Melero
BACKGROUND: Radioimmunotherapy combines irradiation of tumor lesions with immunotherapy to achieve local and abscopal control of cancer. Most immunotherapy agents are given systemically, but strategies for delivering immunotherapy locally are under clinical scrutiny to maximize efficacy and avoid toxicity. Local immunotherapy, by injecting various pathogen-associated molecular patterns, has shown efficacy both preclinically and clinically. BO-112 is a viral mimetic based on nanoplexed double-stranded RNA (poly I:C) which exerts immune-mediated antitumor effects in mice and humans on intratumoral delivery...
January 2023: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/36604098/proshot-dcis-boost-radiation-alone-for-nasopharyngeal-carcinoma-prostate-sbrt-sarcoma-lung-metastases-merkel-cell-carcinoma-abscopal-effect-and-response-adapted-breast-cancer-radiation
#24
EDITORIAL
https://read.qxmd.com/read/36575361/phase-ib-ii-study-of-nivolumab-combined-with-palliative-radiation-therapy-for-bone-metastasis-in-patients-with-her2-negative-metastatic-breast-cancer
#25
JOURNAL ARTICLE
Masahiro Takada, Michio Yoshimura, Takeshi Kotake, Kosuke Kawaguchi, Ryuji Uozumi, Masako Kataoka, Hironori Kato, Hiroshi Yoshibayashi, Hirofumi Suwa, Wakako Tsuji, Hiroyasu Yamashiro, Eiji Suzuki, Masae Torii, Yosuke Yamada, Tatsuki Kataoka, Hiroshi Ishiguro, Satoshi Morita, Masakazu Toi
Radiation therapy (RT) can enhance the abscopal effect of immune checkpoint blockade. This phase I/II study investigated the efficacy and safety of nivolumab plus RT in HER2-negative metastatic breast cancer requiring palliative RT for bone metastases. Cohort A included luminal-like disease, and cohort B included both luminal-like and triple-negative disease refractory to standard systemic therapy. Patients received 8 Gy single fraction RT for bone metastasis on day 0. Nivolumab was administered on day 1 for each 14-day cycle...
December 27, 2022: Scientific Reports
https://read.qxmd.com/read/36538368/carrier-free-nanoplatform-via-evoking-pyroptosis-and-immune-response-against-breast-cancer
#26
JOURNAL ARTICLE
Lei Li, Hailong Tian, Zhe Zhang, Ning Ding, Kai He, Shuaijun Lu, Ruolan Liu, Peijie Wu, Yu Wang, Bo He, Maochao Luo, Peilan Peng, Mao Yang, Edouard C Nice, Canhua Huang, Na Xie, Dong Wang, Wei Gao
Pyroptosis, as a novel mode of cell death, has been proven to have impressive antitumor effects. Dying cells undergoing pyroptosis can elicit antitumor immunity by the release of tumor-associated antigens (TAAs) and damage-associated molecular patterns (DAMPs). Accordingly, developing an effective, stable, and controllable nanoplatform that can promote these two side effects is a promising option for cancer therapy. In this study, we designed a carrier-free chemo-photodynamic nanoplatform (A-C/NPs) using a co-assembly strategy with cytarabine (Ara-C) and chlorin e6 (Ce6) to induce pyroptosis and a subsequent immune response against breast cancer...
December 20, 2022: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/36521291/intralesional-bacillus-calmette-gu%C3%A3-rin-injections-and-hypo-fractionated-radiation-synergistically-induce-systemic-antitumor-immune-responses
#27
JOURNAL ARTICLE
Hanshan Yang, Yuru Hu, Deyi Kong, Ping Chen, Linglin Yang
Radiotherapy, an important treatment for multiple malignancies, produces systemic anti-tumor effects in combination with immunotherapies, especially immune checkpoint inhibitors (ICBs). However, for some patients who do not respond to ICB treatment or show ICB-induced autoimmune symptoms, new alternatives need to be explored. Innovative immunomodulatory strategies, including the administration of immunostimulants, could be used to improve the immunogenicity induced by radiotherapy. In this study, we explored the synergistic effect of Bacillus Calmette-Guérin (BCG) combined with hypo-fractionated radiotherapy (H-RT) in inducing anti-tumor immune responses...
December 13, 2022: International Immunopharmacology
https://read.qxmd.com/read/36514083/gaseous-nitric-oxide-tumor-ablation-induces-an-anti-tumor-abscopal-effect
#28
JOURNAL ARTICLE
Hila Confino, Frederick M Dirbas, Matan Goldshtein, Shay Yarkoni, Rinat Kalaora, Meital Hatan, Shani Puyesky, Yakir Levi, Lidor Malka, Matt Johnson, Selena Chaisson, Jedidiah M Monson, Amir Avniel, Steve Lisi, David Greenberg, Ido Wolf
BACKGROUND: In-situ tumor ablation provides the immune system with the appropriate antigens to induce anti-tumor immunity. Here, we present an innovative technique for generating anti-tumor immunity by delivering exogenous ultra-high concentration (> 10,000 ppm) gaseous nitric oxide (UHCgNO) intratumorally. METHODS: The capability of UHCgNO to induce apoptosis was tested in vitro in mouse colon (CT26), breast (4T1) and Lewis lung carcinoma (LLC-1) cancer cell lines...
December 13, 2022: Cancer Cell International
https://read.qxmd.com/read/36389815/an-update-on-the-use-of-cryoablation-and-immunotherapy-for-breast-cancer
#29
REVIEW
Akindele Olagunju, Tia Forsman, Robert C Ward
The use of cryoablation, a minimally-invasive image-guided technique to target and kill cancer cells, continues to gain traction within the medical field and with patients. This includes the use of cryoablation for the treatment of small breast cancers and focal sites of metastatic disease. In comparison to open surgical approaches, length of hospital stay and recovery time are decreased with the use of cryoablation. Research studies have also found that cryoablation may actually enhance tumor susceptibility to immunotherapy agents...
2022: Frontiers in Immunology
https://read.qxmd.com/read/36303207/combination-of-an-autophagy-inhibitor-with-immunoadjuvants-and-an-anti-pd-l1-antibody-in-multifunctional-nanoparticles-for-enhanced-breast-cancer-immunotherapy
#30
JOURNAL ARTICLE
Yibin Cheng, Caixia Wang, Huihui Wang, Zhiwei Zhang, Xiaopeng Yang, Yanming Dong, Lixin Ma, Jingwen Luo
BACKGROUND: The application of combination therapy for cancer treatment is limited due to poor tumor-specific drug delivery and the abscopal effect. METHODS: Here, PD-L1- and CD44-responsive multifunctional nanoparticles were developed using a polymer complex of polyethyleneimine and oleic acid (PEI-OA) and loaded with two chemotherapeutic drugs (paclitaxel and chloroquine), an antigen (ovalbumin), an immunopotentiator (CpG), and an immune checkpoint inhibitor (anti-PD-L1 antibody)...
October 28, 2022: BMC Medicine
https://read.qxmd.com/read/36287201/-90-y-labeled-gold-nanoparticle-depot-npd-combined-with-anti-pd-l1-antibodies-strongly-inhibits-the-growth-of-4t1-tumors-in-immunocompetent-mice-and-induces-an-abscopal-effect-on-a-distant-non-irradiated-tumor
#31
JOURNAL ARTICLE
Zhongli Cai, Rella Liu, Conrad Chan, Yijie Lu, Mitchell A Winnik, David W Cescon, Raymond M Reilly
The effectiveness and normal tissue toxicity of a novel nanoparticle depot (NPD) brachytherapy seed incorporating gold nanoparticles (AuNPs) labeled with β-particle emitting, 90 Y (termed a "radiation nanomedicine"), were studied for the treatment of 4T1 triple-negative murine mammary carcinoma tumors in Balb/c mice and for inducing an abscopal effect on a distant non-irradiated tumor alone or combined with anti-PD-L1 immune checkpoint antibodies. Balb/c mice with two subcutaneous 4T1 tumors─a primary tumor and a distant secondary tumor were implanted intratumorally (i...
October 26, 2022: Molecular Pharmaceutics
https://read.qxmd.com/read/36199973/the-abscopal-effect-systematic-review-in-patients-with-brain-and-spine-metastases
#32
REVIEW
Dhiraj J Pangal, Benjamin Yarovinsky, Tyler Cardinal, David J Cote, Jacob Ruzevick, Frank J Attenello, Eric L Chang, Jason Ye, Josh Neman, Frances Chow, Gabriel Zada
Background: The abscopal effect is a rare phenomenon whereby local radiation induces a proposed immune-mediated anti-tumor effect at distant sites. Given the growing use of immunotherapies and systemic immune checkpoint inhibitors in neuro-oncologic practice, we aimed to review prior studies pertaining to this phenomenon in the context of tumor shrinkage both within the central nervous system as well as distant disease sites. Methods: A systematic review in accordance with the PRISMA guidelines was conducted to identify all studies which assessed the abscopal effect in patients with treated metastatic cancer to the brain and/or spine...
January 2022: Neuro-oncology advances
https://read.qxmd.com/read/36171008/combination-of-a-novel-heat-shock-protein-90-targeted-photodynamic-therapy-with-pd-1-pd-l1-blockade-induces-potent-systemic-antitumor-efficacy-and-abscopal-effect-against-breast-cancers
#33
JOURNAL ARTICLE
Kensuke Kaneko, Chaitanya R Acharya, Hiroshi Nagata, Xiao Yang, Zachary Conrad Hartman, Amy Hobeika, Philip F Hughes, Timothy A J Haystead, Michael A Morse, Herbert Kim Lyerly, Takuya Osada
BACKGROUND: We previously demonstrated potent antitumor activity against human breast cancer xenografts using photodynamic therapy (PDT) targeting a novel tumor-specific photosensitizer (HS201), which binds heat shock protein 90 (HS201-PDT). However, induction of systemic antitumor immunity by HS201-PDT alone or by the combination strategy with immune checkpoint blockade has yet to be determined. METHODS: Using unilateral and bilateral implantation models of syngeneic breast tumors (E0771, MM3MG-HER2, and JC-HER3) in mice, we assessed whether HS201-PDT could induce local and systemic antitumor immunity...
September 2022: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/36012709/tumor-specific-immunoenhancing-effects-after-local-cryoablation-for-metastatic-bone-tumor-in-a-mouse-model
#34
JOURNAL ARTICLE
Ryohei Annen, Satoshi Kato, Satoru Demura, Shinji Miwa, Akira Yokka, Kazuya Shinmura, Noriaki Yokogawa, Noritaka Yonezawa, Motoya Kobayashi, Yuki Kurokawa, Toshifumi Gabata, Hiroyuki Tsuchiya
We investigated the abscopal effect after cryoablation (CA) on bone metastasis using a mouse model. Breast cancer cells were implanted in the bilateral tibiae of mice. The left tumor was treated locally with CA, and the right abscopal tumor (AT) was left untreated. The mice were divided into four groups based on the combination of CA and intraperitoneal administration of anti-PD-1 antibody (PD) as treatment interventions (Control, CA, PD, and CA + PD). The reduction ratio of the size of AT, the quantitative immune effects at enzyme-linked immunospot (ELISPOT) assay, and the intensity of infiltration of immune-related cells to AT were compared among the groups...
August 21, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/35967277/immunogenic-hydrogel-toolkit-disturbing-residual-tumor-seeds-and-pre-metastatic-soil-for-inhibition-of-postoperative-tumor-recurrence-and-metastasis
#35
JOURNAL ARTICLE
Minglu Zhou, Qingting Zuo, Yuan Huang, Lian Li
Tumor recurrence and metastasis is the leading cause of mortality for postoperative breast cancer patients. However, chemotherapy intervention after surgery is often unsatisfactory, because residual microtumors are difficult to target and require frequent administration. Here, an all-in-one and once-for-all drug depot based on in situ -formed hydrogel was applied to fit the irregular surgical trauma, and enable direct contact with residual tumors and sustained drug release. Our immunological analysis after resection of orthotopic breast tumor revealed that postsurgical activation of CXCR4-CXCL12 signal exacerbated the immunosuppression and correlated with adaptive upregulation of PD-L1 in recurrent tumors...
August 2022: Acta Pharmaceutica Sinica. B
https://read.qxmd.com/read/35955613/targeting-tumor-acidosis-and-regulatory-t-cells-unmasks-anti-metastatic-potential-of-local-tumor-ablation-in-triple-negative-breast-cancer
#36
JOURNAL ARTICLE
Corrine A Nief, Alana Gonzales, Erika Chelales, Júlia Sroda Agudogo, Brian T Crouch, Smita K Nair, Nirmala Ramanujam
Triple-negative breast cancer (TNBC) is an immunologically heterogenous disease that lacks clinically actionable targets and is more likely to progress to metastatic disease than other types of breast cancer. Tumor ablation has been used to increase response rates to checkpoint inhibitors, which remain low for TNBC patients. We hypothesized that tumor ablation could produce an anti-tumor response without using checkpoint inhibitors if immunosuppression (i.e., Tregs, tumor acidosis) was subdued. Tumors were primed with sodium bicarbonate (200 mM p...
July 30, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/35954434/induction-of-bystander-and-abscopal-effects-after-electroporation-based-treatments
#37
JOURNAL ARTICLE
Paulius Ruzgys, Diana Navickaitė, Rūta Palepšienė, Dovilė Uždavinytė, Neringa Barauskaitė, Vitalij Novickij, Irutė Girkontaitė, Brigita Šitkauskienė, Saulius Šatkauskas
Electroporation-based antitumor therapies, including bleomycin electrotransfer, calcium electroporation, and irreversible electroporation, are very effective on directly treated tumors, but have no or low effect on distal nodules. In this study, we aimed to investigate the abscopal effect following calcium electroporation and bleomycin electrotransfer and to find out the effect of the increase of IL-2 serum concentration by muscle transfection. The bystander effect was analyzed in in vitro studies on 4T1tumor cells, while abscopal effect was investigated in an in vivo setting using Balb/c mice bearing 4T1 tumors...
August 2, 2022: Cancers
https://read.qxmd.com/read/35780226/an-in-situ-hydrogel-mediated-chemo-immunometabolic-cancer-therapy
#38
JOURNAL ARTICLE
Bo Wang, Jing Chen, Julia S Caserto, Xi Wang, Minglin Ma
Metabolic reprogramming of the tumor microenvironment (TME) and poor immunogenicity are two of the challenges that cancer immunotherapies have to overcome for improved clinical benefits. Among various immunosuppressive metabolites that keep anti-tumor immunity in check, the tryptophan catabolite kynurenine (Kyn) is an attractive target for blockade given its role in mediating immunosuppression through multiple pathways. Here, we present a local chemo-immunometabolic therapy through injection of a supramolecular hydrogel concurrently releasing doxorubicin that induces immunogenic tumor cell death and kynureninase that disrupts Kyn-mediated immunosuppressive pathways in TME...
July 2, 2022: Nature Communications
https://read.qxmd.com/read/35681672/combination-of-ox40-co-stimulation-radiotherapy-and-pd-1-inhibition-in-a-syngeneic-murine-triple-negative-breast-cancer-model
#39
JOURNAL ARTICLE
Min Guk Han, Chan Woo Wee, Mi Hyun Kang, Min Ji Kim, Seung Hyuck Jeon, In Ah Kim
Immune checkpoint inhibitors have been successful in a wide range of tumor types but still have limited efficacy in immunologically cold tumors, such as breast cancers. We hypothesized that the combination of agonistic anti-OX40 (α-OX40) co-stimulation, PD-1 blockade, and radiotherapy would improve the therapeutic efficacy of the immune checkpoint blockade in a syngeneic murine triple-negative breast cancer model. Murine triple-negative breast cancer cells (4T1) were grown in immune-competent BALB/c mice, and tumors were irradiated with 24 Gy in three fractions...
May 29, 2022: Cancers
https://read.qxmd.com/read/35453571/combining-radiotherapy-and-immunotherapy-in-metastatic-breast-cancer-current-status-and-future-directions
#40
REVIEW
Steven David, Jennifer Tan, Shankar Siva, Lama Karroum, Peter Savas, Sherene Loi
The role of radiotherapy and immunotherapy with immune checkpoint inhibitors (ICI) is of emerging interest in many solid tumours, including breast cancer. There is increasing evidence that the host's immune system plays an important role in influencing the response to treatment and prognosis in breast cancer. Several pre-clinical studies and clinical trials have reported on the 'abscopal effect-regression of distant untreated tumour sites, mediated by an immunological response following ionizing radiation to a targeted tumour site...
March 31, 2022: Biomedicines
keyword
keyword
81344
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.