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abscopal breast cancer

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https://www.readbyqxmd.com/read/27675591/radiation-induced-tumor-targeting-of-immunomodulatory-aptamers-induces-abscopal-response-and-tumor-control-in-murine-models-of-breast-cancer
#1
B Schrand, A P Benaduce, E Gilboa, A S Ishkanian
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27550452/abscopal-effects-of-radiotherapy-are-enhanced-by-combined-immunostimulatory-mabs-and-are-dependent-on-cd8-t-cells-and-crosspriming
#2
María E Rodriguez-Ruiz, Inmaculada Rodriguez, Saray Garasa, Benigno Barbes, Jose Luis Solorzano, Jose Luis Perez-Gracia, Sara Labiano, Miguel F Sanmamed, Arantza Azpilikueta, Elixabet Bolaños, Alfonso R Sanchez-Paulete, M Angela Aznar, Ana Rouzaut, Kurt A Schalper, Maria Jure-Kunkel, Ignacio Melero
Preclinical and clinical evidence indicate that the proimmune effects of radiotherapy can be synergistically augmented with immunostimulatory mAbs to act both on irradiated tumor lesions and on distant, nonirradiated tumor sites. The combination of radiotherapy with immunostimulatory anti-PD1 and anti-CD137 mAbs was conducive to favorable effects on distant nonirradiated tumor lesions as observed in transplanted MC38 (colorectal cancer), B16OVA (melanoma), and 4T1 (breast cancer) models. The therapeutic activity was crucially performed by CD8 T cells, as found in selective depletion experiments...
October 15, 2016: Cancer Research
https://www.readbyqxmd.com/read/26307977/inhibition-of-nf-%C3%AE%C2%BAb-in-tumor-cells-exacerbates-immune-cell-activation-following-photodynamic-therapy
#3
Mans Broekgaarden, Milan Kos, Freek A Jurg, Adriaan A van Beek, Thomas M van Gulik, Michal Heger
Although photodynamic therapy (PDT) yields very good outcomes in numerous types of superficial solid cancers, some tumors respond suboptimally to PDT. Novel treatment strategies are therefore needed to enhance the efficacy in these therapy-resistant tumors. One of these strategies is to combine PDT with inhibitors of PDT-induced survival pathways. In this respect, the transcription factor nuclear factor κB (NF-κB) has been identified as a potential pharmacological target, albeit inhibition of NF-κB may concurrently dampen the subsequent anti-tumor immune response required for complete tumor eradication and abscopal effects...
2015: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26095785/local-radiotherapy-and-granulocyte-macrophage-colony-stimulating-factor-to-generate-abscopal-responses-in-patients-with-metastatic-solid-tumours-a-proof-of-principle-trial
#4
COMPARATIVE STUDY
Encouse B Golden, Arpit Chhabra, Abraham Chachoua, Sylvia Adams, Martin Donach, Maria Fenton-Kerimian, Kent Friedman, Fabio Ponzo, James S Babb, Judith Goldberg, Sandra Demaria, Silvia C Formenti
BACKGROUND: An abscopal response describes radiotherapy-induced immune-mediated tumour regression at sites distant to the irradiated field. Granulocyte-macrophage colony-stimulating factor is a potent stimulator of dendritic cell maturation. We postulated that the exploitation of the pro-immunogenic effects of radiotherapy with granulocyte-macrophage colony-stimulating factor might result in abscopal responses among patients with metastatic cancer. METHODS: Patients with stable or progressing metastatic solid tumours, on single-agent chemotherapy or hormonal therapy, with at least three distinct measurable sites of disease, were treated with concurrent radiotherapy (35 Gy in ten fractions, over 2 weeks) to one metastatic site and granulocyte-macrophage colony-stimulating factor (125 μg/m(2) subcutaneously injected daily for 2 weeks, starting during the second week of radiotherapy)...
July 2015: Lancet Oncology
https://www.readbyqxmd.com/read/25684548/inhibitory-effects-of-autologous-%C3%AE-irradiated-cell-conditioned-medium-on-osteoblasts-in-vitro
#5
Xu-Fang Li, Guo-Ying Zhu, Jian-Ping Wang, Yu Wang
Skeletal complications from radiation therapy have been reported in patients with breast, brain and pelvic cancer, and types of blood cancer. However, it remains to be elucidated whether localized radiotherapy may result in systemic adverse effects on the unirradiated skeleton through an abscopal mechanism. The present study investigated the abscopal effect of radiation on osteoblasts mediated by autologous γ-irradiated cell conditioned medium. Osteoblasts obtained from calvarial bones were incubated with irradiated cell conditioned medium (ICCM) and changes in cell viability, alkaline phosphatase (ALP) activity, mineralization ability, cell apoptosis and the gene expression levels of ALP, osteocalcin (BGP), osteoprotegerin (OPG), receptor activator of nuclear factor-κB ligand (RANKL) and caspase 3 were observed...
July 2015: Molecular Medicine Reports
https://www.readbyqxmd.com/read/24704845/biological-complexities-in-radiation-carcinogenesis-and-cancer-radiotherapy-impact-of-new-biological-paradigms
#6
Hossein Mozdarani
Although radiation carcinogenesis has been shown both experimentally and epidemiologically, the use of ionizing radiation is also one of the major modalities in cancer treatment. Various known cellular and molecular events are involved in carcinogenesis. Apart from the known phenomena, there could be implications for carcinogenesis and cancer prevention due to other biological processes such as the bystander effect, the abscopal effect, intrinsic radiosensitivity and radioadaptation. Bystander effects have consequences for mutation initiated cancer paradigms of radiation carcinogenesis, which provide the mechanistic justification for low-dose risk estimates...
2012: Genes
https://www.readbyqxmd.com/read/12408314/pathophysiological-effects-of-radiation-on-atherosclerosis-development-and-progression-and-the-incidence-of-cardiovascular-complications
#7
REVIEW
Sekhara Rao Basavaraju, Clay E Easterly
Radiation therapy while important in the management of several diseases, is implicated in the causation of atherosclerosis and other cardiovascular complications. Cancer and atherosclerosis go through the same stages of initiation, promotion, and complication, beginning with a mutation in a single cell. Clinical observations before the 1960s lead to the belief that the heart is relatively resistant to the doses of radiation used in radiotherapy. Subsequently, it was discovered that the heart is sensitive to radiation and many cardiac structures may be damaged by radiation exposure...
October 2002: Medical Physics
https://www.readbyqxmd.com/read/6422095/-relationship-between-radiotherapy-and-tumor-immunity-in-hosts
#8
S Mikuriya, S Kamimura, T Kato, H Ooami, T Oda
There are several opinions which denied therapeutic effects of preoperative irradiation, however, we have obtained favorable results by preoperative irradiation for the advanced breast and stomach cancers. Because we treated them by less-fractionated irradiation method with a large dose instead of conventional fractionated one. We adopted this kind of radiation method for the purpose of enhancing the antigenicity of the cancer cells (that means to inhibit the suppression of immune reaction in hosts). Cases of advanced breast cancer were irradiated with 30 Gy at once or 10 Gy at three times a week (total 30 Gy) by betatron electron and we treated advanced stomach cancer with twice a week method (5 Gy or 3 Gy each time, total 40 Gy) by 6 MV X-ray...
October 1983: Gan No Rinsho. Japan Journal of Cancer Clinics
https://www.readbyqxmd.com/read/2730083/-the-therapeutic-effects-of-ok-432-combined-adoptive-immunotherapy-ait-against-liver-metastases-of-breast-cancer
#9
T Okino, N Kan, M Nakanishi, K Satoh, K Mise, S Yamasaki, Y Teramura, T Hori, H Kodama, K Ohgaki
We studied the effect of OK-432 combined AIT in 24 cases of liver metastases of breast cancer. Eleven of the 16 patients (69%) who received intraarterial transfer responded to this therapy. On the other hand, no patients responded to intravenous or intraportal transfer. The minimum cell number for a therapeutic response was 10(9) cells. Four patients had abscopal effects after therapy. The serum CEA level paralleled the therapeutic effects. There were no severe side effects accompanying this therapy. These results indicate that intra-arterial OK-432 combined AIT should be the first choice therapy against liver metastases of breast cancer...
April 1989: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/2398302/-therapeutic-efficacy-of-pre-operative-radiotherapy-on-breast-carcinoma-in-special-reference-to-its-abscopal-effect-on-metastatic-lymph-nodes
#10
K Konoeda
UNLABELLED: The abscopal effect is the radiation response in tissue at a distance from the irradiated site invoked by local irradiation. It is reported that the abscopal effect is observed occasionally in the cases of radiotherapy for malignant lymphoma, malignant melanoma and seminoma. However, pathophysiology and mechanism of the abscopal effect have not been well defined. An aim of this study was to investigate the pathophysiology and mechanism of the abscopal effect in patients with breast carcinoma...
June 20, 1990: Nihon Gan Chiryo Gakkai Shi
https://www.readbyqxmd.com/read/120402/-evaluation-of-abscopal-effect-observed-in-advanced-cancer-of-breast-treated-with-preoperative-radiotherapy-author-s-transl
#11
S Mikuriya, T Saito, K Konoeda, T Matsuba, A Torii, O Sato, H Adachi, R Yokohari, K Yamada, T Asano, K Matsumura, T Seto, O Takatani
No abstract text is available yet for this article.
October 20, 1979: Nihon Gan Chiryo Gakkai Shi
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