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https://www.readbyqxmd.com/read/29222869/new-generation-cardioverter-defibrillator-lead-with-a-floating-atrial-sensing-dipole-long-term-performance
#1
Erdal Safak, Giuseppe D Ancona, Hilmi Kaplan, Evren Caglayan, Stephan Kische, Alper Öner, Hüseyin Ince, Jasmin Ortak
OBJECTIVES: Study aim is to present the long-term performance of a new generation implantable cardioverter defibrillator (ICD) electrode with floating atrial dipole (Linox S DX, Biotronik). BACKGROUND: The single ICD electrode with a floating dipole in the atrial chamber was introduced about 15 years ago to overcome risk of inappropriate shock. METHODS: After implant, internal ECG data were prospectively collected via tele-monitoring (Home Monitoring, Biotronik)...
December 9, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29222045/challenges-in-risk-estimation-using-routinely-collected-clinical-data-the-example-of-estimating-cervical-cancer-risks-from-electronic-health-records
#2
Rebecca Landy, Li C Cheung, Mark Schiffman, Julia C Gage, Noorie Hyun, Nicolas Wentzensen, Walter K Kinney, Philip E Castle, Barbara Fetterman, Nancy E Poitras, Thomas Lorey, Peter D Sasieni, Hormuzd A Katki
Electronic health-records (EHR) are increasingly used by epidemiologists studying disease following surveillance testing to provide evidence for screening intervals and referral guidelines. Although cost-effective, undiagnosed prevalent disease and interval censoring (in which asymptomatic disease is only observed at the time of testing) raise substantial analytic issues when estimating risk that cannot be addressed using Kaplan-Meier methods. Based on our experience analysing EHR from cervical cancer screening, we previously proposed the logistic-Weibull model to address these issues...
December 5, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29221681/hypercalcemic-crisis-and-primary-hyperparathyroidism-cause-of-an-unusual-electrical-storm
#3
Tatiana Guimarães, Miguel Nobre Menezes, Diogo Cruz, Sónia do Vale, Armando Bordalo, Arminda Veiga, Fausto J Pinto, Dulce Brito
Hypercalcemia is a known cause of heart rhythm disorders, however its association with ventricular arrhythmias is rare. The authors present a case of a fifty-three years old male patient with a ischemic and ethanolic dilated cardiomyopathy, and severely reduced ejection fraction, carrier of cardiac resynchronization therapy (CRT) with cardioverter defibrillator (ICD), admitted in the emergency department with an electrical storm, with multiple appropriated ICD shocks, refractory to antiarrhythmic therapy. In the etiological investigation was documented severe hypercalcemia secondary to primary hyperparathyroidism undiagnosed until then...
December 5, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29219952/early-onset-posterior-subscapular-cataract-in-a-series-of-myotonic-dystrophy-type-2-patients
#4
C Papadopoulos, K Kekou, S Xirou, S Kitsiou-Tzeli, E Kararizou, G K Papadimas
PurposeEarly onset posterior subscapular cataract (<50 years of age) is a characteristic feature of myotonic dystrophy type 2 (DM2). Nevertheless, despite being operated at a young age, many patients remain undiagnosed for years. The purpose of this study was to assess the prevalence of early onset posterior subscapular cataract as a presenting symptom of the disease in a cohort of patients with DM2.Patients and methodsWe retrospectively reviewed medical records of DM2 patients followed in our institution for the presence of early onset posterior subscapular cataract, of any secondary causes of cataract, of the age of onset of muscle weakness and of final disease diagnosis...
December 8, 2017: Eye
https://www.readbyqxmd.com/read/29219815/hitting-the-right-target-diagnosing-undiagnosed-hiv-patients-in-the-netherlands
#5
H A B Prins, C Rokx
No abstract text is available yet for this article.
November 2017: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29219811/non-targeted-hiv-screening-in-emergency-departments-in-the-netherlands
#6
G P M Luiken, I K Joore, A Taselaar, S C E Schuit, S E Geerlings, A Govers, P P M Rood, J M Prins, B E Nichols, A Verbon, T E M S de Vries-Sluijs
BACKGROUND: In the Netherlands a substantial proportion of newly diagnosed human immunodeficiency virus (HIV) patients present late for care and an estimated 12-34% of people living with HIV are undiagnosed. Linkage to care of these patients is important to decrease HIV transmission and to improve individual patient outcomes. We investigated if non-targeted HIV testing in emergency departments is a useful and cost-effective way to identify these patients. METHODS: In a cross-sectional multicentre study, eligible adult patients who underwent phlebotomy were given an active choice to be additionally tested for HIV...
November 2017: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29219752/negative-surgical-exploration-in-patients-with-cushing-s-disease-benefit-of-two-thirds-gland-resection-on-remission-rate-and-a-review-of-the-literature
#7
Steven B Carr, Bette K Kleinschmidt-DeMasters, Janice M Kerr, Katja Kiseljak-Vassiliades, Margaret E Wierman, Kevin O Lillehei
OBJECTIVE The authors report their single-institution experience with the pathological findings, rates of remission, and complications in patients with presumed Cushing's disease (CD) who underwent a two-thirds pituitary gland resection when no adenoma was identified at the time of transsphenoidal surgery (TSS). The authors also review the literature on patients with CD, negative surgical exploration, and histological findings. METHODS This study is a retrospective analysis of cases found in neurosurgery and pathology department databases between 1989 and 2011...
December 8, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29219666/coincidence-of-celiac-disease-with-nongastrointestinal-tumors-in-children
#8
Majid Naderi, Iraj Shahramian, Mojtaba Delaramnasab, Ali Bazi
The association of celiac disease (CD) with cancers of gastrointestinal origin has been noted. However, coincidence of CD with nongastrointestinal neoplasms is an unusual event. Here we present five children with concurrent CD and nongastrointestinal neoplasms. All of the patients had positive serologic results for anti-tTG antibodies. Histological investigation of intestinal mucosa showed inflammation (Marsh score = 2) in all the patients. Two of these patients represented with germ cell malignancies. One patient had Wilms' tumor...
December 8, 2017: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29218313/factors-associated-with-number-of-duodenal-samples-obtained-in-suspected-celiac-disease
#9
Leonid Shamban, Serge Sorser, Stan Naydin, Benjamin Lebwohl, Mousa Shukr, Charlotte Wiemann, Daniel Yevsyukov, Michael H Piper, Bradley Warren, Peter H R Green
Background and study aims:  Many people with celiac disease are undiagnosed and there is evidence that insufficient duodenal samples may contribute to underdiagnosis. The aims of this study were to investigate whether more samples leads to a greater likelihood of a diagnosis of celiac disease and to elucidate factors that influence the number of samples collected. Patients and methods:  We identified patients from two community hospitals who were undergoing duodenal biopsy for indications (as identified by International Classification of Diseases code) compatible with possible celiac disease...
December 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29216696/-undetected-traumatic-posterior-glenohumeral-dislocation
#10
J A Rosas-Medina
INTRODUCTION: Glenohumeral dislocation (GHD) is frequent, but traumatic posterior glenohumeral dislocation (TPGHD) is rare, with an incidence of 1-4% of all GHD. The diagnosis is a challenge: sometimes, it can be omitted due to incorrect diagnosis, absence of consideration in the differential diagnosis, suboptimal radiographic evaluation and an absence of characteristic signs and symptoms; missed diagnosis reaches 60-79% and the diagnosis can delay from 24 hours to a year. OBJECTIVE: To transmit previous experiences to provide support for better diagnosing TPGHD, favoring appropriate attention...
July 2017: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/29215092/improvement-in-the-sensitivity-of-newborn-screening-for-fabry-disease-among-females-through-the-use-of-a-high-throughput-and-cost-effective-method-dna-mass-spectrometry
#11
Yung-Hsiu Lu, Po-Hsun Huang, Li-Yun Wang, Ting-Rong Hsu, Hsing-Yuan Li, Pi-Chang Lee, Yu-Ping Hsieh, Sheng-Che Hung, Yu-Chen Wang, Sheng-Kai Chang, Ya-Ting Lee, Ping-Hsun Ho, Hui-Chen Ho, Dau-Ming Niu
Many female carriers of Fabry disease are likely to develop severe morbidity and mortality. However, by our own estimation, around 80% of female newborns are missed by our current enzyme-based screening approach. Our team's aim was to develop an improved cost-effective screening method that is able to detect Fabry disease among female newborns. In Taiwan, based on a database of 916,000 newborns, ~98% of Fabry patients carry mutations out of a pool of only 21 pathogenic mutations. An Agena iPLEX platform was designed to detect these 21 pathogenic mutations using only a single-assay panel...
November 15, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/29214564/undiagnosed-diseases-italy-us-collaboration-and-international-efforts-to-tackle-rare-and-common-diseases-lacking-a-diagnosis
#12
Domenica Taruscio, Giovanna Floridia, Marco Salvatore, Stephen C Groft, William A Gahl
Rare diseases (RD), according to European Union criteria, affect 5 per 10,000 persons, or 30 million people, in the EU; in the USA, RD are defined as conditions that affect fewer than 200,000 individuals in the population (320 million). Most known rare disorders are severe and chronic, with many being degenerative and life threatening. There are roughly 5000-8000 rare diseases (European Commission, DG Health and Food Safety, Public Health, Rare Diseases, Policy.http://ec.europa.eu/health/rare_diseases/policy/index_en...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29214182/thyroid-dysfunction-among-greek-patients-with-type-1-and-type-2-diabetes-mellitus-as-a-disregarded-comorbidity
#13
Maria E Barmpari, Maria Kokkorou, Anastasia Micheli, Irene Alexiou, Elefteria Spanou, Marina Noutsou, Anastasia Thanopoulou
Introduction: The aim of this study was to determine the prevalence of thyroid dysfunction in Greek patients with type 1 (T1DM) and type 2 (T2DM) diabetes mellitus as well as its possible relations to glycaemic control and to diabetic complications. Methods: A total of 1015 patients, consecutively followed in the Outpatient Diabetes Center, were studied. Anthropometric and biochemical measurements, occurrence of diabetes complications, and classical comorbidities were assessed...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29212452/the-effectiveness-of-physiologically-based-early-warning-or-track-and-trigger-systems-after-triage-in-adult-patients-presenting-to-emergency-departments-a-systematic-review
#14
Francesca Wuytack, Pauline Meskell, Aislinn Conway, Fiona McDaid, Nancy Santesso, Fergal G Hickey, Paddy Gillespie, Adam J N Raymakers, Valerie Smith, Declan Devane
BACKGROUND: Changes to physiological parameters precede deterioration of ill patients. Early warning and track and trigger systems (TTS) use routine physiological measurements with pre-specified thresholds to identify deteriorating patients and trigger appropriate and timely escalation of care. Patients presenting to the emergency department (ED) are undiagnosed, undifferentiated and of varying acuity, yet the effectiveness and cost-effectiveness of using early warning systems and TTS in this setting is unclear...
December 6, 2017: BMC Emergency Medicine
https://www.readbyqxmd.com/read/29210826/high-acceptability-and-increased-hiv-testing-frequency-following-introduction-of-hiv-self-testing-and-network-distribution-among-south-african-msm
#15
Sheri A Lippman, Tim Lane, Oscar Rabede, Hailey Gilmore, Yea-Hung Chen, Nkuli Mlotshwa, Kabelo Maleke, Alexander Marr, James A McIntyre
BACKGROUND: South African men-who-have-sex-with-men (MSM) have a high burden of undiagnosed HIV infection and HIV-testing rates incommensurate with their risk. HIV self-testing (HIVST) may increase testing uptake, frequency, and earlier HIV detection and treatment. SETTING: Gert Sibande and Ehlanzeni districts, Mpumalanga Province, South Africa. METHODS: We conducted a longitudinal HIVST study among MSM between June 2015 - May 2017. Overall 127 HIV-negative MSM were provided with up to nine test kits of their choice - oral fluid or blood fingerstick - to use themselves and distribute to their networks...
November 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29210096/obesity-and-type-2-diabetes-are-important-risk-factors-underlying-previously-undiagnosed-cirrhosis-in-general-practice-a-cross-sectional-study-using-transient-elastography
#16
D J Harman, S D Ryder, M W James, E A Wilkes, T R Card, G P Aithal, I N Guha
BACKGROUND: Rising cirrhosis incidence and mortality in the United Kingdom has been attributed predominantly to excess alcohol consumption. However, metabolic risk factors such as Type 2 diabetes and obesity may also be important. AIM: To screen at-risk individuals in general practice for undetected cirrhosis using transient elastography and study the risk factors underlying these cases. METHODS: The study was undertaken in 4 general practices (adult patient population 20 868) between February 2012 and September 2014...
December 6, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29209438/incorporation-of-suboptimal-health-status-as-a-potential-risk-assessment-for-type-ii-diabetes-mellitus-a-case-control-study-in-a-ghanaian-population
#17
Eric Adua, Peter Roberts, Wei Wang
Due to a paradigm shift in lifestyles, there is growing concern that type 2 diabetes mellitus (T2DM) will reach epidemic proportions in Ghana. However, specific characteristics of the disease are under explored in this region. More challenging are those yet to be diagnosed or who complain of poor health in the absence of a diagnosed disease-suboptimal health status (SHS). We conducted a study to examine various factors that characterise SHS and T2DM. Using a cross-sectional design, we recruited 264 people as controls and 241 T2DM patients from January to June 2016...
December 2017: EPMA Journal
https://www.readbyqxmd.com/read/29208508/scientific-evidence-on-the-links-between-periodontal-diseases-and-diabetes-consensus-report-and-guidelines-of-the-joint-workshop-on-periodontal-diseases-and-by-the-international-diabetes-federation-and-the-european-federation-of-periodontology
#18
Mariano Sanz, Antonio Ceriello, Martin Buysschaert, Iain Chapple, Ryan T Demmer, Filippo Graziani, David Herrera, Søren Jepsen, Luca Lione, Phoebus Madianos, Manu Mathur, Eduard Montanya, Lior Shapira, Maurizio Tonetti, Daniel Vegh
BACKGROUND: Diabetes and periodontitis are chronic non-communicable diseases independently associated with mortality and have a bidirectional relationship. AIMS: To update the evidence for their epidemiological and mechanistic associations and re-examine the impact of effective periodontal therapy upon metabolic control (glycated haemoglobin, HbA1C). EPIDEMIOLOGY: There is strong evidence that people with periodontitis have elevated risk for dysglycaemia and insulin resistance...
December 2, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29208159/reduction-in-undiagnosed-hiv-infection-in-the-european-union-european-economic-area-2012-to-2016
#19
Ard van Sighem, Anastasia Pharris, Chantal Quinten, Teymur Noori, Andrew J Amato-Gauci, The Ecdc Hiv/Aids Surveillance And Dublin Declaration Monitoring Networks
It is well-documented that early HIV diagnosis and linkage to care reduces morbidity and mortality as well as HIV transmission. We estimated the median time from HIV infection to diagnosis in the European Union/European Economic Area (EU/EEA) at 2.9 years in 2016, with regional variation. Despite evidence of a decline in the number of people living with undiagnosed HIV in the EU/EEA, many remain undiagnosed, including 33% with more advanced HIV infection (CD4 < 350 cells/mm3).
November 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29207846/tiny-creature-in-oral-cavity-a-case-report
#20
Cheena Singh, M Parvathi Devi, Kamal Sagar
Oral cavity is nidus of much pathology. Some may arise due to altered eating habits such as meat, uncooked food etc. The parasitic infections arising from ingesting uncooked pork (larva of pork tapeworm) called as cysticercosis and being undiagnosed lead to "diagnostic dilemma". Herein we report a case of cysticercosis involving the right dorsum of tongue along with review of literature.
September 2017: Journal of Clinical and Diagnostic Research: JCDR
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