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British Journal of Pharmacology

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https://www.readbyqxmd.com/read/29520785/experimental-design-and-analysis-and-their-reporting-ii-updated-and-simplified-guidance-for-authors-and-peer-reviewers
#1
EDITORIAL
Michael J Curtis, Steve Alexander, Giuseppe Cirino, James R Docherty, Christopher H George, Mark A Giembycz, Daniel Hoyer, Paul A Insel, Angelo A Izzo, Yong Ji, David J MacEwan, Christopher G Sobey, S Clare Stanford, Mauro M Teixeira, Sue Wonnacott, Amrita Ahluwalia
This article updates the guidance published in 2015 for authors submitting papers to British Journal of Pharmacology (Curtis et al., 2015) and is intended to provide the rubric for peer review. Thus, it is directed towards authors, reviewers and editors. Explanations for many of the requirements were outlined previously and are not restated here. The new guidelines are intended to replace those published previously. The guidelines have been simplified for ease of understanding by authors, to make it more straightforward for peer reviewers to check compliance and to facilitate the curation of the journal's efforts to improve standards...
April 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29505103/interventions-for-eye-movement-disorders-due-to-acquired-brain-injury
#2
REVIEW
Fiona J Rowe, Kerry Hanna, Jennifer R Evans, Carmel P Noonan, Marta Garcia-Finana, Caroline S Dodridge, Claire Howard, Kathryn A Jarvis, Sonia L MacDiarmid, Tallat Maan, Lorraine North, Helen Rodgers
BACKGROUND: Acquired brain injury can cause eye movement disorders which may include: strabismus, gaze deficits and nystagmus, causing visual symptoms of double, blurred or 'juddery' vision and reading difficulties. A wide range of interventions exist that have potential to alleviate or ameliorate these symptoms. There is a need to evaluate the effectiveness of these interventions and the timing of their implementation. OBJECTIVES: We aimed to assess the effectiveness of any intervention and determine the effect of timing of intervention in the treatment of strabismus, gaze deficits and nystagmus due to acquired brain injury...
March 5, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29442380/marketing-medicines-charting-the-rise-of-modern-therapeutics-through-a-systematic-review-of-adverts-in-uk-medical-journals-1950-1980
#3
REVIEW
A Richard Green, Peter M Haddad, Jeffrey K Aronson
AIMS: To examine how pharmaceutical products that were first marketed between 1950 and 1980 were promoted to physicians through advertisements and briefly review advertising regulations and accuracy of the advertisements in the light of modern knowledge. METHODS: We systematically reviewed advertisements promoting drugs for specific therapeutic areas, namely central nervous system disorders (anxiety and sleep disorders, depression, psychoses, and Parkinson's disease), respiratory disorders, cardiovascular disorders, and gastrointestinal disorders...
February 14, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29384525/mtor-inhibitor-based-combination-therapies-for-pancreatic-cancer
#4
Zonera Hassan, Christian Schneeweis, Matthias Wirth, Christian Veltkamp, Zahra Dantes, Benedikt Feuerecker, Güralp O Ceyhan, Shirley K Knauer, Wilko Weichert, Roland M Schmid, Roland Stauber, Alexander Arlt, Oliver H Krämer, Roland Rad, Maximilian Reichert, Dieter Saur, Günter Schneider
BACKGROUND: Although the mechanistic target of rapamycin (MTOR) kinase, included in the mTORC1 and mTORC2 signalling hubs, has been demonstrated to be active in a significant fraction of patients with pancreatic ductal adenocarcinoma (PDAC), the value of the kinase as a therapeutic target needs further clarification. METHODS: We used Mtor floxed mice to analyse the function of the kinase in context of the pancreas at the genetic level. Using a dual-recombinase system, which is based on the flippase-FRT (Flp-FRT) and Cre-loxP recombination technologies, we generated a novel cellular model, allowing the genetic analysis of MTOR functions in tumour maintenance...
February 6, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29350411/goals-and-practicalities-of-immunoblotting-and-immunohistochemistry-a-guide-for-submission-to-the-british-journal-of-pharmacology
#5
EDITORIAL
Steve P H Alexander, Richard E Roberts, Brad R S Broughton, Christopher G Sobey, Christopher H George, S Clare Stanford, Giuseppe Cirino, James R Docherty, Mark A Giembycz, Daniel Hoyer, Paul A Insel, Angelo A Izzo, Yong Ji, David J MacEwan, Jonathan Mangum, Sue Wonnacott, Amrita Ahluwalia
No abstract text is available yet for this article.
February 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29235106/wnt-signalling-mechanisms-and-therapeutic-opportunities
#6
EDITORIAL
Gunnar Schulte, Vitezslav Bryja
This themed section of the British Journal of Pharmacology stems from the EMBO Conference: Wnt Meeting 2016 held from the 14th to 16th September 2016 in Brno, Czech Republic. LINKED ARTICLES: This article is part of a themed section on WNT Signalling: Mechanisms and Therapeutic Opportunities. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.24/issuetoc.
December 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29140555/withdrawn-electrical-cardioversion-for-atrial-fibrillation-and-flutter
#7
REVIEW
Gillian E Mead, Andrew Elder, Andrew D Flapan, John Cordina
BACKGROUND: Atrial fibrillation increases stroke risk and adversely affects cardiovascular haemodynamics. Electrical cardioversion may, by restoring sinus rhythm, improve cardiovascular haemodynamics, reduce the risk of stroke, and obviate the need for long-term anticoagulation. OBJECTIVES: To assess the effects of electrical cardioversion of atrial fibrillation or flutter on the risk of thromboembolic events, strokes and mortality (primary outcomes), the rate of cognitive decline, quality of life, the use of anticoagulants and the risk of re-hospitalisation (secondary outcomes) in adults (>18 years)...
November 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29080212/targeting-inflammation-to-reduce-cardiovascular-disease-risk
#8
EDITORIAL
Pasquale Maffia, Giuseppe Cirino
This joint themed section of the British Journal of Pharmacology and the British Journal of Clinical Pharmacology stems from a joint British Pharmacological Society - Italian Society of Pharmacology symposium held at the 37th National Congress of the Italian Society of Pharmacology in Naples (Italy) from 27 to 30 October 2015. LINKED ARTICLES: This article is part of a themed section on Targeting Inflammation to Reduce Cardiovascular Disease Risk. To view the other articles in this section visit http://onlinelibrary...
November 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28934562/the-enduring-legacy-of-250-years-of-pharmacology-in-edinburgh
#9
John S Kelly, Angus V P Mackay
In 1768, 250 years ago, the University of Edinburgh appointed Francis Home to the first chair of materia medica, the accumulated knowledge of materials used in healing. Francis Home and his colleagues were determined to improve the quality of medical training in Edinburgh by introducing a final examination and compiling a catalog of medicines validated by the Royal College of Physicians of Edinburgh. The catalog, known as the Edinburgh Pharmacopoeia, was a great success, partly due to the orderly nature of its contents, its routine editing to eliminate worthless entries, and the introduction of new treatments whose preparation was precisely documented...
January 6, 2018: Annual Review of Pharmacology and Toxicology
https://www.readbyqxmd.com/read/28881358/ligand-dependent-hedgehog-pathway-activation-in-rhabdomyosarcoma-the-oncogenic-role-of-the-ligands
#10
A Almazán-Moga, P Zarzosa, C Molist, P Velasco, J Pyczek, K Simon-Keller, I Giralt, I Vidal, N Navarro, M F Segura, A Soriano, S Navarro, O M Tirado, J C Ferreres, A Santamaria, R Rota, H Hahn, J Sánchez de Toledo, J Roma, S Gallego
BACKGROUND: Rhabdomyosarcoma (RMS) is the most common type of soft tissue sarcoma in children. The Hedgehog (HH) pathway is known to develop an oncogenic role in RMS. However, the molecular mechanism that drives activation of the pathway in RMS is not well understood. METHODS: The expression of HH ligands was studied by qPCR, western blot and immunohistochemistry. Functional and animal model studies were carried out with cells transduced with shRNAs against HH ligands or treated with HH-specific inhibitors (Vismodegib and MEDI-5304)...
October 24, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28873082/ffar2-expression-regulates-leukaemic-cell-growth-in-vivo
#11
Laure B Bindels, Paolo E Porporato, Sarah Ducastel, Martina Sboarina, Audrey M Neyrinck, Evelyne M Dewulf, Olivier Feron, Sophie Lestavel, Patrice D Cani, Bart Staels, Pierre Sonveaux, Nathalie M Delzenne
BACKGROUND: Activation of free fatty acid receptor 2 (FFAR2) by microbiota-derived metabolites (e.g., propionate) reduces leukaemic cell proliferation in vitro. This study aims to test whether Ffar2 expression per se also influences leukaemia cell growth in vivo. METHODS: Bcr-Abl-expressing BaF cells were used as a leukaemia model and the role of Ffar2 was evaluated in Balb/c mice after lentiviral shRNA transduction. RESULTS: Our data formally establish that reduced leukaemic cell proliferation is associated with increased Ffar2 expression in vivo and in vitro...
October 24, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28817838/pharmacogenetic-determinants-of-outcomes-on-triplet-hepatic-artery-infusion-and-intravenous-cetuximab-for-liver-metastases-from-colorectal-cancer-european-trial-optiliv-nct00852228
#12
Francis Lévi, Abdoulaye Karaboué, Raphaël Saffroy, Christophe Desterke, Valerie Boige, Denis Smith, Mohamed Hebbar, Pasquale Innominato, Julien Taieb, Carlos Carvalho, Rosine Guimbaud, Christian Focan, Mohamed Bouchahda, René Adam, Michel Ducreux, Gérard Milano, Antoinette Lemoine
BACKGROUND: The hepatic artery infusion (HAI) of irinotecan, oxaliplatin and 5-fluorouracil with intravenous cetuximab achieved outstanding efficacy in previously treated patients with initially unresectable liver metastases from colorectal cancer. This planned study aimed at the identification of pharmacogenetic predictors of outcomes. METHODS: Circulating mononuclear cells were analysed for 207 single-nucleotide polymorphisms (SNPs) from 34 pharmacology genes...
September 26, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28801996/updating-the-guidelines-for-data-transparency-in-the-british-journal-of-pharmacology-data-sharing-and-the-use-of-scatter-plots-instead-of-bar-charts
#13
EDITORIAL
Christopher H George, S Clare Stanford, Steve Alexander, Giuseppe Cirino, James R Docherty, Mark A Giembycz, Daniel Hoyer, Paul A Insel, Angelo A Izzo, Yong Ji, David J MacEwan, Christopher G Sobey, Sue Wonnacott, Amrita Ahluwalia
No abstract text is available yet for this article.
September 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28797031/regulation-of-hypoxia-induced-autophagy-in-glioblastoma-involves-atg9a
#14
Siti Aminah Abdul Rahim, Anne Dirkse, Anais Oudin, Anne Schuster, Jill Bohler, Vanessa Barthelemy, Arnaud Muller, Laurent Vallar, Bassam Janji, Anna Golebiewska, Simone P Niclou
BACKGROUND: Hypoxia is negatively associated with glioblastoma (GBM) patient survival and contributes to tumour resistance. Anti-angiogenic therapy in GBM further increases hypoxia and activates survival pathways. The aim of this study was to determine the role of hypoxia-induced autophagy in GBM. METHODS: Pharmacological inhibition of autophagy was applied in combination with bevacizumab in GBM patient-derived xenografts (PDXs). Sensitivity towards inhibitors was further tested in vitro under normoxia and hypoxia, followed by transcriptomic analysis...
September 5, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28797028/characterisation-of-the-cancer-associated-glucocorticoid-system-key-role-of-11%C3%AE-hydroxysteroid-dehydrogenase-type-2
#15
Nicola Cirillo, David J Morgan, Maria Carmela Pedicillo, Antonio Celentano, Lorenzo Lo Muzio, Michael J McCullough, Stephen S Prime
BACKGROUND: Recent studies have shown that production of cortisol not only takes place in several non-adrenal peripheral tissues such as epithelial cells but, also, the local inter-conversion between cortisone and cortisol is regulated by the 11β-hydroxysteroid dehydrogenases (11β-HSDs). However, little is known about the activity of this non-adrenal glucocorticoid system in cancers. METHODS: The presence of a functioning glucocorticoid system was assessed in human skin squamous cell carcinoma (SCC) and melanoma and further, in 16 epithelial cell lines from 8 different tissue types using ELISA, western blotting and immunofluorescence...
September 26, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28718196/retracted-cannabinoid-cb-2-receptors-modulate-erk-1-2-kinase-signalling-and-no-release-in-microglial-cells-stimulated-with-bacterial-lipopolysaccharide-by-s-merighi-s-gessi-k-varani-c-simioni-d-fazzi-p-mirandola-and-p-a-borea-british-journal-of-pharmacology
#16
(no author information available yet)
The above article, published by the British Journal of Pharmacology in March 2012 (http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01673.x/full), has been retracted by agreement between the authors, the Journal Editor in Chief and John Wiley & Sons Ltd. The authors wish to state that in preparation of the original manuscript errors occurred resulting in duplication. This issue relates specifically to Figures 2A and 2B, lanes 3-5 of the pJNK1/2 in Figure 3B and lanes 1-3 of the pJNK1/2 blot from Figure 3C...
August 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28609434/pharmacologically-directed-strategies-in-academic-anticancer-drug-discovery-based-on-the-european-nci-compounds-initiative
#17
Hans R Hendriks, Anne-Sophie Govaerts, Iduna Fichtner, Sally Burtles, Andrew D Westwell, Godefridus J Peters
BACKGROUND: The European NCI compounds programme, a joint initiative of the EORTC Research Branch, Cancer Research Campaign and the US National Cancer Institute, was initiated in 1993. The objective was to help the NCI in reducing the backlog of in vivo testing of potential anticancer compounds, synthesised in Europe that emerged from the NCI in vitro 60-cell screen. METHODS: Over a period of more than twenty years the EORTC-Cancer Research Campaign panel reviewed ∼2000 compounds of which 95 were selected for further evaluation...
July 11, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28441382/hedgehog-signalling-pathway-orchestrates-angiogenesis-in-triple-negative-breast-cancers
#18
Concetta Di Mauro, Roberta Rosa, Valentina D'Amato, Paola Ciciola, Alberto Servetto, Roberta Marciano, Roberta Clara Orsini, Luigi Formisano, Sandro De Falco, Valeria Cicatiello, Maurizio Di Bonito, Monica Cantile, Francesca Collina, Angela Chambery, Bianca Maria Veneziani, Sabino De Placido, Roberto Bianco
BACKGROUND: Several evidences suggest a marked angiogenic dependency in triple-negative breast cancer (TNBC) tumorigenesis and a potential sensitivity to anti-angiogenic agents. Herein, the putative role of Hedgehog (Hh) pathway in regulating TNBC-dependent angiogenesis was investigated. METHODS: Expression and regulation of the Hh pathway transcription factor glioma-associated oncogene homolog1 protein (GLI1) were studied on the endothelial compartment and on TNBC-initiated angiogenesis...
May 23, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28397257/retracted-mice-lacking-the-raf-1-kinase-inhibitor-protein-exhibit-exaggerated-hypoxia-induced-pulmonary-hypertension-by-i-morecroft-b-doyle-m-nilsen-w-kolch-k-mair-and-mr-maclean-british-journal-of-pharmacology-volume-163-5-948-963-published-in-june-2011-doi
#19
(no author information available yet)
The above article, published by the British Journal of Pharmacology in June 2011 (http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01305.x/full), has been retracted by agreement between the authors, the Journal Editor in Chief and John Wiley & Sons Ltd. Formal internal investigations by the British Journal of Pharmacology have concluded that inappropriate manipulation of western blots depicted in Figures 1, 8 and 9 has occurred. The non-corresponding authors (M MacLean, B Doyle, K Mair, M Nilsen, W Kolch) wish to state that they had no knowledge that the figures in question had been manipulated...
May 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28222068/inhibition-of-cdk5-induces-cell-death-of-tumor-initiating-cells
#20
Melanie M Mandl, Siwei Zhang, Melanie Ulrich, Elisa Schmoeckel, Doris Mayr, Angelika M Vollmar, Johanna Liebl
BACKGROUND: Tumour-initiating cells (TICs) account for chemoresistance, tumour recurrence and metastasis, and therefore represent a major problem in tumour therapy. However, strategies to address TICs are limited. Recent studies indicate Cdk5 as a promising target for anti-cancer therapy and Cdk5 has recently been associated with epithelial-mesenchymal transition (EMT). However, a role of Cdk5 in TICs has not been described yet. METHODS: Expression of Cdk5 in human cancer tissue was analysed by staining of a human tissue microarray (TMA)...
March 28, 2017: British Journal of Cancer
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