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https://www.readbyqxmd.com/read/28324872/changing-trends-and-practices-in-cytopathology
#1
Maria F Gonzalez, Israh Akhtar, Varsha Manucha
OBJECTIVE: To explore the current and anticipated changes in the practice of cytopathology. STUDY DESIGN: The present review is based on a review of recent literature and an evaluation of the authors' personal experiences. RESULTS AND CONCLUSION: In recent years the practice of cytopathology, nationwide and in our institute, has witnessed a major change affecting gynecologic and nongynecologic cytology. There has been a decline in the number of Papanicolaou tests which has affected the utilization of cytotechnologists and provoked a reorganization of their work flow...
March 22, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/28315995/ligand-based-virtual-screening-under-partial-shape-constraints
#2
Mathias M von Behren, Matthias Rarey
Ligand-based virtual screening has proven to be a viable technology during the search for new lead structures in drug discovery. Despite the rapidly increasing number of published methods, meaningful shape matching as well as ligand and target flexibility still remain open challenges. In this work, we analyze the influence of knowledge-based sterical constraints on the performance of the recently published ligand-based virtual screening method mRAISE. We introduce the concept of partial shape matching enabling a more differentiated view on chemical structure...
March 18, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28314726/global-distribution-patterns-and-pangenomic-diversity-of-the-candidate-phylum-latescibacteria-ws3
#3
Ibrahim F Farag, Noha H Youssef, Mostafa S Elshahed
We investigated the global distribution patterns and pangenomic diversity of the candidate phylum "Latescibacteria" (WS3) in 16S rRNA gene as well as metagenomic datasets. We document distinct distribution patterns for various "Latescibacteria" orders in 16S rRNA gene datasets, with prevalence of orders sediment_1 in terrestrial, PBSIII_9 in groundwater and temperate freshwater, and GN03 in pelagic marine, saline-hypersaline, and wastewater habitats. Using a fragment recruitment approach, we identified 68.9 Mb of "Latescibacteria"-affiliated contigs in publicly available metagenomic datasets comprising 73,079 proteins...
March 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28303388/the-impact-of-antibiotic-stewardship-programs-in-combating-quinolone-resistance-a-systematic-review-and-recommendations-for-more-efficient-interventions
#4
REVIEW
Vasiliki Pitiriga, Georgia Vrioni, George Saroglou, Athanasios Tsakris
Quinolones are among the most commonly prescribed antibiotics worldwide. A clear relationship has been demonstrated between excessive quinolone use and the steady increase in the incidence of quinolone-resistant bacterial pathogens, both in hospital and community sites. In addition, exposure to quinolones has been associated with colonization and infection with healthcare-associated pathogens such as methicillin-resistant Staphylococcus aureus and Clostridium difficile in hospitalized patients. Therefore, the management of quinolone prescribing in hospitals through antibiotic stewardship programs is considered crucial...
March 16, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28302593/outcomes-in-child-health-exploring-the-use-of-social-media-to-engage-parents-in-patient-centered-outcomes-research
#5
Michele P Dyson, Kassi Shave, Ricardo M Fernandes, Shannon D Scott, Lisa Hartling
BACKGROUND: With the rapid growth of technology and its improved accessibility globally, social media is gaining an increasingly important role in health care. Patients are frequently engaging with social media to access information, share content, and interact with others in online health communities. However, the use of social media as a stakeholder engagement strategy has been minimally explored, and effective methods for involving participants in research on the identification of patient-centered outcomes remain unknown...
March 16, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28301474/histidine-rich-protein-2-pfhrp2-and-pfhrp3-gene-deletions-in-plasmodium-falciparum-isolates-from-select-sites-in-brazil-and-bolivia
#6
Giselle Maria Rachid Viana, Sheila Akinyi Okoth, Luciana Silva-Flannery, Danielle Regina Lima Barbosa, Alexandre Macedo de Oliveira, Ira F Goldman, Lindsay C Morton, Curtis Huber, Arletta Anez, Ricardo Luiz Dantas Machado, Luís Marcelo Aranha Camargo, Suiane Costa Negreiros do Valle, Marinete Marins Póvoa, Venkatachalam Udhayakumar, John W Barnwell
More than 80% of available malaria rapid diagnostic tests (RDTs) are based on the detection of histidine-rich protein-2 (PfHRP2) for diagnosis of Plasmodium falciparum malaria. Recent studies have shown the genes that code for this protein and its paralog, histidine-rich protein-3 (PfHRP3), are absent in parasites from the Peruvian Amazon Basin. Lack of PfHRP2 protein through deletion of the pfhrp2 gene leads to false-negative RDT results for P. falciparum. We have evaluated the extent of pfhrp2 and pfhrp3 gene deletions in a convenience sample of 198 isolates from six sites in three states across the Brazilian Amazon Basin (Acre, Rondonia and Para) and 25 isolates from two sites in Bolivia collected at different times between 2010 and 2012...
2017: PloS One
https://www.readbyqxmd.com/read/28300856/halobetasol-propionate-lotion-0-05-provides-superior-hydration-compared-to-halobetasol-propionate-cream-0-05-in-a-double-blinded-study-of-occlusivity-and-hydration
#7
Gary Grove, Charles Zerweck, Tim Houser, Anthony Andrasfay, Bob Gauthier, Charles Holland, Daniel Piacquadio
BACKGROUND: This study measured skin hydration and occlusivity of two test products [halobetasol propionate lotion, 0.05% (HBP Lotion) and Ultravate® (halobetasol propionate) cream, 0.05% (HBP Cream)] at 2, 4, and 6 hours after application to skin test sites previously challenged by dry shaving, which was performed to compromise the integrity of the stratum corneum barrier. METHODS: Trans-epidermal water loss (TEWL), an indicator of skin barrier function, was measured using cyberDERM, inc...
February 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28296309/characterization-and-evaluation-of-2-5-mv-electronic-portal-imaging-for-accurate-localization-of-intra-and-extracranial-stereotactic-radiosurgery
#8
Kwang Hyun Song, Karen Chin Snyder, Jinkoo Kim, Haisen Li, Wen Ning, Robert Rusnac, Paul Jackson, James Gordon, Salim M Siddiqui, Indrin J Chetty
2.5 MV electronic portal imaging, available on Varian TrueBeam machines, was characterized using various phantoms in this study. Its low-contrast detectability, spatial resolution, and contrast-to-noise ratio (CNR) were compared with those of conventional 6 MV and kV planar imaging. Scatter effect in large patient body was simulated by adding solid water slabs along the beam path. The 2.5 MV imaging mode was also evaluated using clinically acquired images from 24 patients for the sites of brain, head and neck, lung, and abdomen...
July 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28296023/closure-of-patent-forman-ovale-defects-using-gore%C3%A2-cardioform-septal-occluder
#9
Stefan E Hardt, Andreas Eicken, Felix Berger, Stephan Schubert, Mario Carminati, Gianfranco Butera, Jochen Grohmann, Rene Höhn, Jens Erik Nielsen-Kudsk, David Hildick-Smith, Magnus Settergren, John D Thomson, Nicolas Geis, Lars Søndergaard
AIMS: The GORE® CARDIOFORM Septal Occluder (GSO) is a novel device designed for rapid and effective closure of patent foramen ovale (PFO) which has distinctive features making it suitable for a broad spectrum of anatomical variations. We report the procedural and 6 months follow-up results of the first prospective, multicenter study using GSO. METHODS AND RESULTS: This single-arm study included 150 subjects undergoing closure of PFO in 10 European centers. In 149 out of 150 patients implantation of a GSO device was successful...
March 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28290142/rapid-on-site-evaluation-of-cytology-for-eus-and-ebus-guided-fine-needle-aspiration
#10
EDITORIAL
Kartik Ramakrishna
No abstract text is available yet for this article.
March 14, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28275079/multicentre-evaluation-of-the-cepheid-xpert%C3%A2-hepatitis-c-virus-hcv-viral-load-assay
#11
M P McHugh, A H B Wu, S Chevaliez, J M Pawlotsky, M Hallin, K E Templeton
Viral load monitoring for hepatitis C virus (HCV) is necessary to diagnose infection and monitor response to therapy but the tests involved are currently confined to specialist institutions. There is need for a fast, accurate assay with limited operator input to enhance the access to viral load monitoring. We evaluated the quantification of HCV RNA in serum and plasma by the Cepheid Xpert® HCV Viral Load assay in comparison to the Abbott RealTime HCV assay. Serum and plasma samples from HCV infected individuals at four international sites were gathered...
March 8, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28274594/preparation-of-immobilized-coating-fenton-like-catalyst-for-high-efficient-degradation-of-phenol
#12
Jiankang Wang, Zhongping Yao, Yajing Wang, Qixing Xia, Huiya Chu, Zhaohua Jiang
In this study, solid acid amorphous Fe3O4/SiO2 ceramic coating decorated with sulfur on Q235 carbon steel as Fenton-like catalyst for phenol degradation was successfully prepared by plasma electrolytic oxidation (PEO) in silicate electrolyte containing Na2S2O8 as sulfur source. The surface morphology and phase composition were characterized by SEM, EDS, XRD and XPS analyses. NH3-TPD was used to evaluate surface acidity of PEO coating. The results indicated that sulfur decorated amorphous Fe3O4/SiO2 ceramic coatings with porous structure and higher acid strength had the similar pore size and the surface became more and more uneven with the increase of Na2S2O8 in the silicate electrolyte...
March 6, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28273485/clinical-factors-of-response-in-patients-with-advanced-ovarian-cancer-participating-in-early-phase-clinical-trials
#13
Angela George, Rebecca Kristeleit, Saeed Rafii, Caroline O Michie, Rebecca Bowen, Vasiliki Michalarea, Tom van Hagen, Mabel Wong, Grigorios Rallis, L Rhoda Molife, Juanita Lopez, Udai Banerji, Susana N Banerjee, Martin E Gore, Johann S de Bono, Stan B Kaye, Timothy A Yap
Drug resistance to conventional anticancer therapies is almost inevitable in patients with advanced ovarian cancer (AOC), limiting their available treatment options. Novel phase I trial therapies within a dedicated drug development unit may represent a viable alternative; however, there is currently little evidence for patient outcomes in such patients. To address this, we undertook a retrospective review of patients with AOC allocated to phase I trials in the Drug Development Unit at Royal Marsden Hospital (RMH) between June 1998 and October 2010...
March 5, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28264502/rapid-and-sensitive-lateral-flow-immunoassay-method-for-procalcitonin-pct-based-on-time-resolved-immunochromatography
#14
Xiang-Yang Shao, Cong-Rong Wang, Chun-Mei Xie, Xian-Guo Wang, Rong-Liang Liang, Wei-Wen Xu
Procalcitonin (PCT) is a current, frequently-used marker for severe bacterial infection. The aim of this study was to develop a cost-effective detection kit for rapid quantitative and on-site detection of PCT. To develop the new PCT quantitative detecting kit, a double-antibody sandwich immunofluorescent assay was employed based on time-resolved immunofluorescent assay (TRFIA) combined with lateral flow immunoassay (LFIA). The performance of the new developed kit was evaluated in the aspects of linearity, precision, accuracy, and specificity...
February 28, 2017: Sensors
https://www.readbyqxmd.com/read/28258904/a-simplified-approach-to-encephalitis-and-its-mimics-key-clinical-decision-points-in-the-setting-of-specific-imaging-abnormalities
#15
Colin D McKnight, Aine M Kelly, Myria Petrou, Anna E Nidecker, Matthew T Lorincz, Duaa K Altaee, Stephen S Gebarski, Bradley Foerster
RATIONALE AND OBJECTIVES: Infectious encephalitis is a relatively common cause of morbidity and mortality. Treatment of infectious encephalitis with antiviral medication can be highly effective when administered promptly. Clinical mimics of encephalitis arise from a broad range of pathologic processes, including toxic, metabolic, neoplastic, autoimmune, and cardiovascular etiologies. These mimics need to be rapidly differentiated from infectious encephalitis to appropriately manage the correct etiology; however, the many overlapping signs of these various entities present a challenge to accurate diagnosis...
February 28, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28255437/effects-of-a-smoking-ban-on-clozapine-plasma-concentrations-in-a-nonsecure-psychiatric-unit
#16
Siobhan H Gee, David M Taylor, Sukhwinder S Shergill, Robert Flanagan, James H MacCabe
BACKGROUND: Tobacco smoke is known to affect plasma levels of some drugs, including the antipsychotic clozapine. The effects of suddenly stopping smoking on patients who take clozapine can be severe, as plasma concentrations are expected to rapidly rise, potentially leading to toxicity. A ban on smoking at South London and the Maudsley NHS Foundation Trust (SLaM) was implemented in 2014, and this was expected to affect the plasma concentrations of clozapine for inpatients at the time...
February 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28251391/a-multicenter-open-label-long-term-safety-and-tolerability-study-of-dfn-02-an-intranasal-spray-of-sumatriptan-10%C3%A2-mg-plus-permeation-enhancer-ddm-for-the-acute-treatment-of-episodic-migraine
#17
Sagar Munjal, Elimor Brand-Schieber, Kent Allenby, Egilius L H Spierings, Roger K Cady, Alan M Rapoport
BACKGROUND: DFN-02 is a novel intranasal spray formulation composed of sumatriptan 10 mg and a permeation-enhancing excipient comprised of 0.2% 1-O-n-Dodecyl-β-D-Maltopyranoside (DDM). This composition of DFN-02 allows sumatriptan to be rapidly absorbed into the systemic circulation and exhibit pharmacokinetics comparable to subcutaneously administered sumatriptan. Rapid rate of absorption is suggested to be important for optimal efficacy. The objective of this study was to evaluate the safety and tolerability of DFN-02 (10 mg) in the acute treatment of episodic migraine with and without aura over a 6-month period based on the incidence of treatment-emergent adverse events and the evaluation of results of clinical laboratory tests, vital signs, physical examination, and electrocardiograms...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28251264/calcium-induced-mitochondrial-permeability-transitions-parameters-of-ca-2-ion-interactions-with-mitochondria-and-effects-of-oxidative-agents
#18
Nina G Golovach, Vitali T Cheshchevik, Elena A Lapshina, Tatsiana V Ilyich, Ilya B Zavodnik
We evaluated the parameters of Ca(2+)-induced mitochondrial permeability transition (MPT) pore formations, Ca(2+) binding constants, stoichiometry, energy of activation, and the effect of oxidative agents, tert-butyl hydroperoxide (tBHP), and hypochlorous acid (HOCl), on Ca(2+) -mediated process in rat liver mitochondria. From the Hill plot of the dependence of MPT rate on Ca(2+) concentration, we determined the order of interaction of Ca(2+) ions with the mitochondrial sites, n = 3, and the apparent Kd = 60 ± 12 µM...
March 1, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28245129/effect-of-dye-and-conjugation-chemistry-on-the-biodistribution-profile-of-near-infrared-labeled-nanobodies-as-tracers-for-image-guided-surgery
#19
Pieterjan Debie, Jannah Van Quathem, Inge Hansen, Gezim Bala, Sam Massa, Nick Devoogdt, Catarina Xavier, Sophie Hernot
Advances in optical imaging technologies have stimulated the development of near-infrared (NIR) fluorescently labeled targeted probes for use in image-guided surgery. As nanobodies have already proven to be excellent candidates for molecular imaging, we aimed in this project to design NIR-conjugated nanobodies targeting the tumor biomarker HER2 for future applications in this field and to evaluate the effect of dye and dye conjugation chemistry on their pharmacokinetics during development. IRDye800CW or IRdye680RD were conjugated either randomly (via lysines) or site-specifically (via C-terminal cysteine) to the anti-HER2 nanobody 2Rs15d...
March 9, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28241478/design-and-elementary-evaluation-of-a-highly-automated-fluorescence-based-instrument-system-for-on-site-detection-of-food-borne-pathogens
#20
Zhan Lu, Jianyi Zhang, Lizhou Xu, Yanbin Li, Siyu Chen, Zunzhong Ye, Jianping Wang
A simple, highly-automated instrument system used for on-site detection of foodborne pathogens based on fluorescence was designed, fabricated, and preliminarily tested in this paper. A corresponding method has been proved effective in our previous studies. This system utilizes a light-emitting diode (LED) to excite fluorescent labels and a spectrometer to record the fluorescence signal from samples. A rotation stage for positioning and switching samples was innovatively designed for high-throughput detection, ten at most in one single run...
February 23, 2017: Sensors
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