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https://www.readbyqxmd.com/read/28633170/teaching-primary-care-genetics-a-randomized-controlled-trial-comparison
#1
Deanna Telner, June C Carroll, Glenn Regehr, Diana Tabak, Kara Semotiuk, Risa Freeman
BACKGROUND AND OBJECTIVE: Given the increasing discussions of the impact of genetic medicine within family medicine, it is important to determine the most effective way of teaching this material to family medicine residents (FMRs). The objective of this study was to evaluate and compare the impact of three methods of delivering primary care genetic content to FMRs. METHODS: Curriculum materials and assessment tools were created to teach and evaluate knowledge, skills, and attitudes around four core competencies in primary care genetics, with a focus on hereditary colorectal cancer (CRC)...
June 2017: Family Medicine
https://www.readbyqxmd.com/read/28625993/survival-of-h5n1-highly-pathogenic-avian-influenza-virus-in-tissues-derived-from-experimentally-infected-chickens
#2
Yu Yamamoto, Kikuyasu Nakamura, Masaji Mase
Eurasian lineage H5N1 highly pathogenic avian influenza (HPAI) virus has been a severe threat to the poultry industry since its emergence in 1996. The carcass or tissues derived from infected birds may have the risk of the virus spreading to humans, animals, and the surrounding environment. In this study, we investigated the survival of the virus in feather, muscle, and liver tissues collected from six chickens (Gallus gallus) experimentally infected with H5N1 HPAI virus. The tissues were stored at +4°C or +20°C and viral isolation was performed at different times for 360 days...
June 16, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28615274/detecting-organisational-innovations-leading-to-improved-icu-outcomes-a-protocol-for-a-double-blinded-national-positive-deviance-study-of-critical-care-delivery
#3
Howard Chiou, Jeffrey K Jopling, Jennifer Yang Scott, Meghan Ramsey, Kelly Vranas, Todd H Wagner, Arnold Milstein
INTRODUCTION: There is substantial variability in intensive care unit (ICU) utilisation and quality of care. However, the factors that drive this variation are poorly understood. This study uses a novel adaptation of positive deviance approach-a methodology used in public health that assumes solutions to challenges already exist within the system to detect innovations that are likely to improve intensive care. METHODS AND ANALYSIS: We used the Philips eICU Research Institute database, containing 3...
June 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28608999/specimen-acquisition-roses-gardeners-and-gatekeepers
#4
Adele O Kraft
The use of minimally invasive procedures for diagnosis and treatment decisions means that very often cytological samples are the only material available for testing. Cytology has evolved from a strictly morphological approach to the routine use of immunohistochemistry. The advent of personalized medicine has increased the demand for molecular testing, making rapid on-site evaluation even more relevant. This article presents current rapid on-site evaluation practice patterns in different settings, with a special focus on the variety of professionals involved...
June 2017: Cancer
https://www.readbyqxmd.com/read/28606148/development-of-a-stochastic-agent-based-model-to-evaluate-surveillance-strategies-for-detection-of-emergent-porcine-reproductive-and-respiratory-syndrome-strains
#5
A G Arruda, Z Poljak, D Knowles, A McLean
BACKGROUND: The objective of the current study was to develop a stochastic agent-based model using empirical data from Ontario (Canada) swine sites in order to evaluate different surveillance strategies for detection of emerging porcine reproductive and respiratory syndrome virus (PRRSV) strains at the regional level. Four strategies were evaluated, including (i) random sampling of fixed numbers of swine sites monthly; (ii) risk-based sampling of fixed numbers, specifically of breeding sites (high-consequence sites); (iii) risk-based sampling of fixed numbers of low biosecurity sites (high-risk); and (iv) risk-based sampling of breeding sites that are characterized as low biosecurity sites (high-risk/high-consequence)...
June 12, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28603895/metastatic-neoplasms-to-the-pancreas-diagnosed-by-fine-needle-aspiration-biopsy-cytology-a-15-year-retrospective-analysis
#6
Sasha L T Raymond, Deanne Yugawa, Karen H F Chang, Brandy Ena, Pamela S Tauchi-Nishi
BACKGROUND: Metastatic tumors to the pancreas are rarely encountered and diagnostically challenging. We aspired to determine the incidence and origin of all metastases to the pancreas at our institution, and to examine their clinicopathologic and cytomorphologic features. We also sought to ascertain the effect of endoscopic ultrasound (EUS) guidance implementation. METHODS: A search of our database was undertaken to review all pancreatic FNA and/or CNB examined from January 2000 through December 2014...
June 11, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28603655/endobronchial-ultrasound-transbronchial-needle-aspiration-for-mediastinal-staging-of-non-small-cell-lung-cancer-variability-of-results-and-perspectives
#7
Elisa Nardecchia, Maria Cattoni, Lorenzo Dominioni
The remarkable value of endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA) for mediastinal staging of non-small cell lung cancer (NSCLC) is recognized worldwide. Reports from different centers however show considerable variation of EBUS-TBNA performance in terms of diagnostic yield, sensitivity and negative predictive value (NPV). Interpretation of EBUS-TBNA diagnostic efficacy requires clarifying whether the technique is used for purely diagnostic purpose or mediastinal staging, recognizing that different study groups may be inherently heterogeneous and that numerous factors may impact on the procedure outcomes...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28603651/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-ebus-tbna-from-morphology-to-molecular-testing
#8
REVIEW
Luisella Righi, Francesca Franzi, Francesca Montarolo, Gaia Gatti, Massimo Bongiovanni, Fausto Sessa, Stefano La Rosa
In recent years, endobronchial ultrasound-guided TBNA (EBUS-TBNA) has emerged as an innovative technique for diagnosis and staging of lung cancer and has been successfully introduced into daily clinical practice with several advantages including minimally invasive approach, safe, cost-effective, real time image guidance, broad sampling capability, and rapid on-site evaluation (ROSE). Both cytological and histological approach could be useful to have material for diagnosis, immunohistochemical and molecular analyses which may be very important for targeted therapy with successful rate ranging from 89% to 98%...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28603649/comparison-of-multiple-techniques-for-endobronchial-ultrasound-transbronchial-needle-aspiration-specimen-preparation-in-a-single-institution-experience
#9
Nicola Rotolo, Maria Cattoni, Giorgio Crosta, Elisa Nardecchia, Albino Poli, Francesca Moretti, Valentina Conti, Stefano La Rosa, Lorenzo Dominioni, Andrea Imperatori
BACKGROUND: The optimal method for specimen preparation of endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA) is still controversial. This study aims to compare several techniques available for EBUS-TBNA specimen acquisition and processing, in order to identify the best performing technique. METHODS: We retrospectively reviewed the data of 199 consecutive patients [male, 73%; median age, 64 years (IQR: 52-74 years)] undergoing EBUS-TBNA at our institution from 2012 through 2014 for diagnosis of hilar-mediastinal lymph node enlargement suspect of neoplastic (n=139) or granulomatous (n=60) disease...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28603033/in-vivo-analysis-of-supersaturation-precipitation-absorption-behavior-after-oral-administration-of-pioglitazone-hydrochloride-salt-determinant-site-of-oral-absorption
#10
Yusuke Tanaka, Masahisa Sugihara, Ayaka Kawakami, So Imai, Takafumi Itou, Hirokazu Murase, Kazunori Saiki, Satoshi Kasaoka, Hiroshi Yoshikawa
The purpose of this study was to evaluate in vivo supersaturation/precipitation/absorption behavior in the gastrointestinal (GI) tract based on the luminal concentration-time profiles after oral administration of pioglitazone (PG, a highly permeable lipophilic base) and its hydrochloride salt (PG-HCl) to rats. In the in vitro precipitation experiment in the classic closed system, while the supersaturation was stable in the simulated gastric condition, PG drastically precipitated in the simulated intestinal condition, particularly at a higher initial degree of supersaturation...
June 9, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28600150/longitudinal-patient-reported-mobility-assessment-in-fibrodysplasia-ossificans-progressiva-fop
#11
Frederick S Kaplan, Mona Al Mukaddam, Robert J Pignolo
BACKGROUND: Fibrodysplasia ossificans progressiva (FOP) is a rare, disabling genetic disorder characterized by episodic soft tissue swelling (flare-ups) that leads to progressive heterotopic ossification and restricted joint mobility. METHODS: Here we present the first longitudinal patient-reported mobility assessment (PRMA) in FOP based on a simple evaluation tool. At initial presentation and follow-up (1-11year span; median: 6 year span), 64 patients (36 females; 28 males) with classic FOP completed a questionnaire designed to rapidly assess mobility at 15 sites (three axial; six upper limb, and six lower limb)...
June 6, 2017: Bone
https://www.readbyqxmd.com/read/28599661/poor-performance-of-quick-sofa-qsofa-score-in-predicting-severe-sepsis-and-mortality-a-prospective-study-of-patients-admitted-with-infection-to-the-emergency-department
#12
Åsa Askim, Florentin Moser, Lise T Gustad, Helga Stene, Maren Gundersen, Bjørn Olav Åsvold, Jostein Dale, Lars Petter Bjørnsen, Jan Kristian Damås, Erik Solligård
BACKGROUND: We aimed to evaluate the clinical usefulness of qSOFA as a risk stratification tool for patients admitted with infection compared to traditional SIRS criteria or our triage system; the Rapid Emergency Triage and Treatment System (RETTS). METHODS: The study was an observational cohort study performed at one Emergency Department (ED) in an urban university teaching hospital in Norway, with approximately 20,000 visits per year. All patients >16 years presenting with symptoms or clinical signs suggesting an infection (n = 1535) were prospectively included in the study from January 1 to December 31, 2012...
June 9, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28598760/the-use-of-modern-dressings-in-managing-split-thickness-skin-graft-donor-sites-a-single-centre-randomised-controlled-trial
#13
M Kazanavičius, A Cepas, V Kolaityte, R Simoliuniene, R Rimdeika
OBJECTIVE: To identify the most appropriate, most suitable and most efficient dressing for split-thickness skin graft (STSG) donor sites. Comparing the wound healing rate, pain severity and duration, as well as the dressing change frequency in four randomised patient groups. METHODS: A single-centre non-blinded randomised controlled trial was carried out during 2010-2014. All patients treated for skin defects/lesions (due to burns, trauma or ulcers) using STSG were included in the study...
June 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28586622/atelocollagen-enhances-the-healing-of-rotator-cuff-tendon-in-rabbit-model
#14
Dong-Sam Suh, Jun-Keun Lee, Ji-Chul Yoo, Sang-Hun Woo, Ga-Ram Kim, Ju-Won Kim, Nam-Yong Choi, Yongdeok Kim, Hyun-Seok Song
BACKGROUND: Failure of rotator cuff healing is a common complication despite the rapid development of surgical repair techniques for the torn rotator cuff. PURPOSE: To verify the effect of atelocollagen on tendon-to-bone healing in the rabbit supraspinatus tendon compared with conventional cuff repair. STUDY DESIGN: Controlled laboratory study. METHODS: A tear of the supraspinatus tendon was created and repaired in 46 New Zealand White rabbits...
June 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28576592/evaluating-the-genomic-yield-of-a-single-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-in-lung-cancer-meeting-the-challenge-of-doing-more-with-less
#15
Tracy L Leong, Michael Christie, Sevastjan Kranz, Kym Pham, Arthur Hsu, Louis B Irving, Marie-Liesse Asselin-Labat, Daniel P Steinfort
BACKGROUND: Minimally invasive techniques, including endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), yield small specimens that are adequate for cytologic diagnosis of lung cancer, but also need to provide material for molecular analysis to guide treatment. The number of EBUS-TBNA passes needed for mutation testing remains unclear. We sought to assess the adequacy of a single pass for genomic profiling of actionable mutations. METHODS: In a prospective observational study, paired samples from the same lesion were obtained from patients undergoing EBUS-TBNA for lung cancer diagnosis/staging...
May 10, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28559704/endobronchial-ultrasound-one-year-of-experience-in-clinical-practice
#16
Marioara Simon, Bogdan Pop, Lacramioara Toma, Aletta Vallasek, Ioan Simon
BACKGROUND AND AIM: Endobronchial ultrasound (EBUS) is a recent minimally invasive, safe examination method for the mediastinum, with a good diagnostic precision. This method makes possible real time examination with transbronchial fine needle aspiration, diagnostic transbronchial needle aspiration (TBNA) and staging of non-small pulmonary tumors, as well as diagnosis of mediastinal and hilar adenopathies of various causes. METHODS: We present the experience of the Bronchoscopy Department of the Pulmonology Clinic of Cluj-Napoca with EBUS-TBNA as a tool for the diagnosis and staging of tumors in contact with the bronchial wall and mediastinal and hilar adenopathies of unknown etiology...
2017: Clujul Medical (1957)
https://www.readbyqxmd.com/read/28558983/enhancing-global-vaccine-pharmacovigilance-proof-of-concept-study-on-aseptic-meningitis-and-immune-thrombocytopenic-purpura-following-measles-mumps-containing-vaccination
#17
Silvia Perez-Vilar, Daniel Weibel, Miriam Sturkenboom, Steven Black, Christine Maure, Jose Luis Castro, Pamela Bravo-Alcántara, Caitlin N Dodd, Silvana A Romio, Maria de Ridder, Swabra Nakato, Helvert Felipe Molina-León, Varalakshmi Elango, Patrick L F Zuber
New vaccines designed to prevent diseases endemic in low and middle-income countries (LMICs) are now being introduced without prior record of utilization in countries with robust pharmacovigilance systems. To address this deficit, our objective was to demonstrate feasibility of an international hospital-based network for the assessment of potential epidemiological associations between serious and rare adverse events and vaccines in any setting. This was done through a proof-of-concept evaluation of the risk of immune thrombocytopenic purpura (ITP) and aseptic meningitis (AM) following administration of the first dose of measles-mumps-containing vaccines using the self-controlled risk interval method in the primary analysis...
May 27, 2017: Vaccine
https://www.readbyqxmd.com/read/28558954/clinical-performance-and-economic-evaluations-of-the-alere%C3%A2-i-influenza-a-b-near-patient-test-using-throat-swabs-a-cohort-diagnostic-accuracy-study-and-cost-analysis
#18
Susanna Davis, Joy Allen, Rachel O'Leary, Michael Power, DAshley Price, John Simpson, Anne Tunbridge, Luke Vale, Michael Whiteside, Cariad Evans, Mohammad Raza
BACKGROUND: Clinical diagnostic sensitivity alone is inadequate in the diagnosis of influenza. PCR testing is sensitive however the inherent delays in result availability potentially prolong time to isolation and treatment. Until recently no near patient test (NPT) has demonstrated adequate sensitivity for routine clinical use. AIM: To evaluate diagnostic accuracy; time to result availability; clinical impact and cost consequences of Alere™ i Influenza A&B NPT (Alere Inc...
May 27, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28553516/a-practical-strategy-to-design-and-develop-an-isoform-specific-fluorescent-probe-for-a-target-enzyme-cyp1a1-as-a-case-study
#19
Zi-Ru Dai, Lei Feng, Qiang Jin, Hailing Cheng, Yan Li, Jing Ning, Yang Yu, Guang-Bo Ge, Jing-Nan Cui, Ling Yang
The development of isoform-specific probe(s) for a target enzyme with multiple homologs is always challenging. Herein, a practical strategy was used to design and develop an isoform-specific probe for CYP1A1, a key cytochrome P450 isoenzyme involved in xenobiotic metabolism and bioactivation. On the basis of the subtle differences in 3D structure and substrate preference between CYP1A1 and its homolog CYP1A2, we proposed that it was possible to design a CYP1A1-specific probe via local modification of the reaction site on known CYP1A substrates...
April 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28550609/validation-of-the-taps-1-a-four-item-screening-tool-to-identify-unhealthy-substance-use-in-primary-care
#20
Jan Gryczynski, Jennifer McNeely, Li-Tzy Wu, Geetha A Subramaniam, Dace S Svikis, Lauretta A Cathers, Gaurav Sharma, Jacqueline King, Eve Jelstrom, Courtney D Nordeck, Anjalee Sharma, Shannon G Mitchell, Kevin E O'Grady, Robert P Schwartz
BACKGROUND: The Tobacco, Alcohol, Prescription Medication, and Other Substance use (TAPS) tool is a combined two-part screening and brief assessment developed for adult primary care patients. The tool's first-stage screening component (TAPS-1) consists of four items asking about past 12-month use for four substance categories, with response options of never, less than monthly, monthly, weekly, and daily or almost daily. OBJECTIVE: To validate the TAPS-1 in primary care patients...
May 26, 2017: Journal of General Internal Medicine
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