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Dermatology treatment

Shenara Musthaq, Anna Mazuy, Jeannette Jakus
The skin supports a delicate ecosystem of microbial elements. Although the skin typically acts as a barrier, these microbes interact with the internal body environment and imbalances from the "healthy" state that have been linked to several dermatologic diseases. Understanding the changes in microbial flora in disease states allows for the potential to treat by restoring equilibrium. With the rising popularity of holistic and natural consumerism, prebiotics, probiotics, symbiotic, and other therapies are under study to find alternative treatments to these skin disorders through manipulation or supplementation of the microbiome...
May 2018: Clinics in Dermatology
Amy Huang, Sophie Seité, Tony Adar
Balneotherapy is the treatment of disease by bathing in thermal spring water. This therapy has been used for centuries and remains a popular form of treatment for dermatologic and rheumatologic diseases today. Although the favorable climates of balneotherapy thermal centers have known beneficial effects on psoriasis and atopic dermatitis, the thermal spring waters themselves can also potentially decrease skin inflammation. The addition of phototherapy to balneotherapy, or balneophototherapy, further enhances the anti-inflammatory effects of thermal spring water...
May 2018: Clinics in Dermatology
Olga Y Olisova, Elena S Snarskaya, Victor V Gladko, Ekaterina P Burova
The use of herbal remedies for various medical issues is becoming increasingly commonplace in all fields of medicine, and dermatology is no exception. This review focuses on traditional dermatologic herbal remedies, commonly used in Russia, as the rich array of 11 different plant zones has resulted in a great variety of medicinal plants. Herbal remedies warrant deeper investigation and research, especially due to their active substance content, which may interfere with or reinforce the effect of modern medications, something that medical professionals should be aware of when prescribing treatments...
May 2018: Clinics in Dermatology
Warren J Winkelman
Complementary and alternative medicine approaches are popular among some patient segments due to the perception that they are "natural" and thus are believed to be less likely to be dangerous, to be less toxic, or to cause fewer side effects. In dermatology, these can include aromatherapy, botanicals, and essential oils (plant extracts). Preliminary evidence, biological activity studies, and small pilot clinical trials conducted outside of North America, mostly in young adults, suggest that some may have value in acne treatment...
May 2018: Clinics in Dermatology
Emma B Holliday, Scott C Lester, W Scott Harmsen, Cathy Eng, Michael G Haddock, Sunil Krishnan, Prajnan Das, Christopher L Hallemeier
PURPOSE: To report cancer control rates and adverse events (AEs) of curative-intent, extended-field chemoradiation therapy administered to patients with squamous cell carcinoma (SCC) of the anal canal presenting with distant metastasis limited to the para-aortic (PA) lymph nodes. METHODS: This was a retrospective review of patients with SCC of the anal canal metastatic to the PA lymph nodes at initial diagnosis who were treated with curative-intent, extended-field chemoradiation therapy between September 2002 and February 2016 at two tertiary care centers...
May 5, 2018: International Journal of Radiation Oncology, Biology, Physics
Andreas Wollenberg, Michael D Howell, Emma Guttman-Yassky, Jonathan I Silverberg, Christopher Kell, Koustubh Ranade, Rachel Moate, René van der Merwe
BACKGROUND: Interleukin (IL)-13 has an important role in atopic dermatitis (AD) pathogenesis. Tralokinumab is a fully human monoclonal antibody that potently and specifically neutralizes IL-13. OBJECTIVE: To evaluate the efficacy and safety of tralokinumab in adults with moderate to severe AD. METHODS: In this phase 2b study (NCT02347176), 204 adults were randomized 1:1:1:1 to receive subcutaneous tralokinumab 45 mg, 150 mg, or 300 mg, or placebo, every 2 weeks for 12 weeks, with concomitant topical glucocorticoids...
June 12, 2018: Journal of Allergy and Clinical Immunology
J Krygier, G Leemans, R Forsyth, A de Becker, J Gutermuth, M Grosber
BACKGROUND: Pityriasis rubra pilaris (PRP) is a cutaneous syndrome of unknown origin. Most cases are sporadic and acquired. Herein we report a fifth case of PRP-like eruption associated with ponatinib, a tyrosine kinase inhibitor (TKI). PATIENTS AND METHODS: A 60-year-old woman presented at the dermatology department with an erythemato-squamous eruption present for 2weeks. The patient was also being treated in haematology for recurrence of acute lymphoblastic leukaemia...
June 11, 2018: Annales de Dermatologie et de Vénéréologie
Frances M Walocko, Ariel E Eber, Robert S Kirsner, Evangelos Badiavas, Keyvan Nouri
BACKGROUND: Adipose tissue has classically functioned as a filler in restoring facial volume. Adipose tissue is also rich in stem cells, which may have a role in regenerative medicine. OBJECTIVE: To summarize the literature on the clinical uses of adipose tissue in scarring, wound healing, and hair growth and determine if evidence exists for clinical practice changes in dermatology. METHODS: We utilized the Preferred Reporting Items for Systemic Reviews and Meta-Analysis (PRISMA) to conduct the review...
June 11, 2018: Journal of the American Academy of Dermatology
Emily B Richard, Diana Hamer, Mandi W Musso, Tracee Short, Hollis R O'Neal
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, type IV hypersensitivity reactions of the skin and mucosa. These reactions (SJS/TEN) are frequently managed in burn units; however, no standardized guidelines exist for the treatment and management of SJS/TEN. To gain insight into current SJS/TEN management practices, a survey on admission, diagnosis, and management, was conducted across accredited burn units in the United States. A 28-item question survey on SJS/TEN management, diagnosis, and treatment practices was distributed among medical directors and co-directors of American Burn Association-verified burn centers...
June 13, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
B Tamási, V Brodszky, M Péntek, L Gulácsi, K Hajdu, M Sárdy, A Szegedi, Z Bata-Csörgő, Á Kinyó, F Rencz
BACKGROUND: No studies have employed the EuroQoL (EQ-5D) questionnaire to assess health-related quality of life (HRQoL) in pemphigus patients, to date. OBJECTIVES: To evaluate HRQoL of pemphigus patients by the EQ-5D and to analyse the convergent and known-groups validity of the EQ-5D in this patient population. METHODS: Between 2014 and 2017, a multicentre cross-sectional study was carried out. Outcome measures included the five-level EQ-5D (EQ-5D-5L), Dermatology Life Quality Index (DLQI), Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) and an average pain intensity visual analogue scale (VAS) for the past three months...
June 13, 2018: British Journal of Dermatology
Miles H Graivier, Lawrence M Bass, Z Paul Lorenc, Rebecca Fitzgerald, David J Goldberg, Gottfried Lemperle
Though the incidence of complications and adverse events with dermatological fillers is inherently low, practitioners should be well versed in both prevention of filler complications and the treatment algorithms for addressing "granulomas," nodules, infection, and vascular compromise. Appropriate preventative measures, coupled with timely and effective treatment, are critically important for patient safety and satisfaction. In addition to the preventive measures and treatment algorithms outlined here, the authors emphasize that the broad classification and treatment of nodules as "granulomas" is likely to lead to ineffective treatment, or worse, unnecessary exposure to incorrect treatment...
April 6, 2018: Aesthetic Surgery Journal
Asako Itakura, Yumiko Tani, Naoko Kaneko, Michihiro Hide
Little attention has been given to the burden of chronic urticaria (CU) in Japan compared with other skin diseases, such as atopic dermatitis (AD) and psoriasis. The primary objective of the RELEASE study was to evaluate the real-life quality-of-life impairment in CU patients in Japan. Data were collected from 1443 urticaria, 1668 AD and 435 psoriatic patients; 552 urticaria patients who presented urticaria symptoms for over 6 weeks were defined as CU. The mean Dermatology Life Quality Index (DLQI) total score was 4...
June 13, 2018: Journal of Dermatology
Sonia Ratib, Esther Burden-Teh, Jo Leonardi-Bee, Catherine Harwood, Fiona Bath-Hextall
OBJECTIVE: The objective of this systematic review was to synthesize available research evidence to determine the risk of skin cancer in patients with long-term use of topical corticosteroids (TCS). INTRODUCTION: Topical corticosteroids are one of the most commonly prescribed medicines in dermatology and the mainstay of the treatment of atopic dermatitis and other skin conditions such as psoriasis. They are often required for months or years to control the disease and ultimately restore patients' quality of life...
June 2018: JBI Database of Systematic Reviews and Implementation Reports
Po-Han Ho, I-Chun Lin, Xinyi Yang, Yung-Tsu Cho, Chia-Yu Chu
BACKGROUND: Oncologic treatments may lead to the development of paronychia, which may cause severe pain and disability. However, a detailed objective scoring system is lacking. OBJECTIVE: To develop an objective scoring system to quantify the severity of paronychia and also examine the correlation of this score with a pain index and patients' quality of life. METHODS: A novel scoring system for paronychia related to oncologic treatment (SPOT), consisting of four parameters, namely redness, edema, discharge, and granulation tissue, was designed to assess the severity of paronychia...
June 12, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Anna Korsgaard Berg, Kirsten Nørgaard, Jacob P Thyssen, Claus Zachariae, Eva Hommel, Karen Rytter, Jannet Svensson
BACKGROUND: In the future, widespread use of closed-loop infusion (artificial pancreas) systems to treat type 1 diabetes (T1D) may significantly improve glycemic control and enhance treatment flexibility. However, the infusion sets and plasters necessary for these treatments can cause dermatological complications that may hamper the spread of the new technology; few studies have investigated these complications in adults. The aim of this study was to describe the dermatological complications associated with continuous subcutaneous insulin infusion (CSII) and continuous glucose monitoring (CGM) in adults...
June 12, 2018: Diabetes Technology & Therapeutics
Atul Deodhar, Alice B Gottlieb, Wolf-Henning Boehncke, Bin Dong, Yuhua Wang, Yanli Zhuang, William Barchuk, Xie L Xu, Elizabeth C Hsia
BACKGROUND: Guselkumab, a human monoclonal antibody that binds to the p19 subunit of interleukin 23, has been approved for the treatment of moderate-to-severe psoriasis. Psoriatic arthritis is a common comorbidity of psoriasis with an umet need for novel treatments. We assessed the efficacy and safety of guselkumab in patients with active psoriatic arthritis. METHODS: We did a randomised, double-blind, placebo-controlled, phase 2a trial at 34 rheumatology and dermatology practices in Canada, Germany, Poland, Romania, Russia, Spain, and the USA...
June 2, 2018: Lancet
Issam Hamadah, Muzamil A Chisti, Mansoor Haider, Yousef Binamer, Saad Alajlan, Yousif Aleyouni, Abdullah Alfadley
BACKGROUND: Pemphigus is a chronic potentially life threatening autoimmune blistering disease affecting the skin and/or mucous membranes. Rituximab is being increasingly used and found efficacious in the treatment of pemphigus. OBJECTIVE: To present the Middle-Eastern experience with the use of rituximab in pemphigus. METHODS: A retrospective analysis of patient files was conducted which revealed twenty-three patients of pemphigus who were treated with rituximab(either alone or with IVIG) in the dermatology department of a tertiary care hospital from July-2004 to Dec-2014...
June 11, 2018: Journal of Dermatological Treatment
Audrey Le, Dimitrios Farmakiotis, John L Reagan
Bleomycin-induced flagellate erythema (FE), a skin finding associated with cutaneous deposition of bleomycin, is so called due to its characteristic pattern of whip-like, linear streaks. As bleomycin use in standard chemotherapeutic regimens has decreased, the clinical diagnosis has become increasingly rare. The authors present a case of a 43-year-old female patient with Hodgkin's lymphoma on her first cycle of adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) treatment, who subsequently developed a diffuse rash classic for FE...
April 8, 2018: Curēus
G Carretero Hernández, C Ferrándiz, R Rivera Díaz, E Daudén Tello, P de la Cueva-Dobao, F J Gómez-García, E Herrera-Ceballos, I Belinchón Romero, J L López-Estebaranz, M Alsina Gibert, J L Sánchez-Carazo, M Ferrán Farrés, A González Quesada, J M Carrascosa Carrillo, M Llamas-Velasco, M V Mendiola Fernández, D Ruiz Genao, C Muñoz Santos, I García-Doval, M A Descalzo
INTRODUCTION AND OBJECTIVES: Biologic drugs are usually prescribed as second-line treatment for psoriasis, that is, after the patient has first been treated with a conventional psoriasis drug. There are, however, cases where, depending on the characteristics of the patient or the judgement of the physician, biologics may be chosen as first-line therapy. No studies to date have analyzed the demographics or clinical characteristics of patients in this setting or the safety profile of the agents used...
June 7, 2018: Actas Dermo-sifiliográficas
Sara Tenti, Marta Fabbroni, Virginia Mancini, Filomena Russo, Mauro Galeazzi, Antonella Fioravanti
Discoid lupus erythematosus (DLE) is a chronic dermatological disease that can lead to scarring, alopecia and dyspigmentation, if not properly treated. Actually, no drugs are specifically approved for the treatment of CLE, although the first-line therapy usually consists of photoprotection associated to topical or oral steroids, topical calcineurin inhibitors and hydroxychloroquine (HCQ). In cases of DLE refractory to these medications, many other agents have been employed, such as dapsone, methotrexate, azathioprine, cyclophosphamide, biologic drugs and Intravenous Immunoglobulin (IVIG)...
June 6, 2018: Autoimmunity Reviews
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