keyword
MENU ▼
Read by QxMD icon Read
search

toxicology emergencies

keyword
https://www.readbyqxmd.com/read/28229951/chemical-and-toxicological-characterizations-of-hydraulic-fracturing-flowback-and-produced-water
#1
Yuhe He, Shannon L Flynn, Erik J Folkerts, Yifeng Zhang, Dongliang Ruan, Daniel S Alessi, Jonathan W Martin, Greg G Goss
Hydraulic fracturing (HF) has emerged as a major method of unconventional oil and gas recovery. The toxicity of hydraulic fracturing flowback and produced water (HF-FPW) has not been previously reported and is complicated by the combined complexity of organic and inorganic constituents in HF fluids and deep formation water. In this study, we characterized the solids, salts, and organic signatures in an HF-FPW sample from the Duvernay Formation, Alberta, Canada. Untargeted HPLC-Orbitrap revealed numerous unknown dissolved polar organics...
February 14, 2017: Water Research
https://www.readbyqxmd.com/read/28224264/how-people-think-about-the-chemicals-in-cigarette-smoke-a-systematic-review
#2
REVIEW
Jennifer C Morgan, M Justin Byron, Sabeeh A Baig, Irina Stepanov, Noel T Brewer
Laws and treaties compel countries to inform the public about harmful chemicals (constituents) in cigarette smoke. To encourage relevant research by behavioral scientists, we provide a primer on cigarette smoke toxicology and summarize research on how the public thinks about cigarette smoke chemicals. We systematically searched PubMed in July 2016 and reviewed citations from included articles. Four central findings emerged across 46 articles that met inclusion criteria. First, people were familiar with very few chemicals in cigarette smoke...
February 21, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28215500/environmental-epigenomics-current-approaches-to-assess-epigenetic-effects-of-endocrine-disrupting-compounds-edc-s-on-human-health
#3
REVIEW
Natalia Tapia-Orozco, Gerardo Santiago-Toledo, Valeria Barrón, Ana María Espinosa-García, José Antonio García-García, Roeb García-Arrazola
Environmental Epigenomics is a developing field to study the epigenetic effect on human health from exposure to environmental factors. Endocrine disrupting chemicals have been detected primarily in pharmaceutical drugs, personal care products, food additives, and food containers. Exposure to endocrine-disrupting chemicals (EDCs) has been associated with a high incidence and prevalence of many endocrine-related disorders in humans. Nevertheless, further evidence is needed to establish a correlation between exposure to EDC and human disorders...
February 10, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28214179/mixture-toxicity-of-flubendazole-and-fenbendazole-to-daphnia-magna
#4
Alan Puckowski, Stefan Stolte, Marta Wagil, Marta Markiewicz, Paulina Łukaszewicz, Piotr Stepnowski, Anna Białk-Bielińska
Nowadays, residual amounts of many pharmaceuticals can be found in various environmental compartments including surface and ground waters, soils and sediments as well as biota. Even though they undergo degradability, their environmental discharge is relatively continuous, thus they may be regarded as quasi-persistent contaminants, and are also frequently regarded as emerging organic pollutants. Benzimidazoles, especially flubendazole (FLU) and fenbendazole (FEN), represent two anthelmintic drugs belonging to this group...
February 3, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28210359/intentional-recreational-abuse-of-quetiapine-compared-to-other-second-generation-antipsychotics
#5
Lauren Klein, Stacey Bangh, Jon B Cole
INTRODUCTION: Case reports and poison center data have demonstrated that the second-generation antipsychotic quetiapine is being obtained and used for recreational abuse. The purpose of this study was to describe the relative rates of single-substance abuse for different atypical antipsychotics and compare their demographic and clinical features. METHODS: We conducted a 10-year retrospective analysis of the National Poison Data System (NPDS) database (2003 - 2013)...
February 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28194688/emergency-department-initiated-buprenorphine-for-opioid-dependence-with-continuation-in-primary-care-outcomes-during-and-after-intervention
#6
Gail D'Onofrio, Marek C Chawarski, Patrick G O'Connor, Michael V Pantalon, Susan H Busch, Patricia H Owens, Kathryn Hawk, Steven L Bernstein, David A Fiellin
BACKGROUND: Emergency department (ED)-initiated buprenorphine/naloxone with continuation in primary care was found to increase engagement in addiction treatment and reduce illicit opioid use at 30 days compared to referral only or a brief intervention with referral. OBJECTIVE: To evaluate the long-term outcomes at 2, 6 and 12 months following ED interventions. DESIGN: Evaluation of treatment engagement, drug use, and HIV risk among a cohort of patients from a randomized trial who completed at least one long-term follow-up assessment...
February 13, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28182988/design-in-silico-studies-synthesis-and-in%C3%A2-vitro-evaluation-of-oseltamivir-derivatives-as-inhibitors-of-neuraminidase-from-influenza-a-virus-h1n1
#7
Rocío M Neri-Bazán, Jazmín García-Machorro, David Méndez-Luna, Luis E Tolentino-López, Federico Martínez-Ramos, Itzia I Padilla-Martínez, Leopoldo Aguilar-Faisal, Marvin A Soriano-Ursúa, José G Trujillo-Ferrara, M Jonathan Fragoso-Vázquez, Blanca L Barrón, José Correa-Basurto
Since the neuraminidase (NA) enzyme of the influenza A virus plays a key role in the process of release of new viral particles from a host cell, it is often a target for new drug design. The emergence of NA mutations, such as H275Y, has led to great resistance against neuraminidase inhibitors, including oseltamivir and zanamivir. Hence, we herein designed a set of derivatives by modifying the amine and/or carboxylic groups of oseltamivir. After being screened for their physicochemical (Lipinski's rule) and toxicological properties, the remaining compounds were submitted to molecular and theoretical studies...
January 24, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28168668/systems-biology-to-support-nanomaterial-grouping
#8
Christian Riebeling, Harald Jungnickel, Andreas Luch, Andrea Haase
The assessment of potential health risks of engineered nanomaterials (ENMs) is a challenging task due to the high number and great variety of already existing and newly emerging ENMs. Reliable grouping or categorization of ENMs with respect to hazards could help to facilitate prioritization and decision making for regulatory purposes. The development of grouping criteria, however, requires a broad and comprehensive data basis. A promising platform addressing this challenge is the systems biology approach. The different areas of systems biology, most prominently transcriptomics, proteomics and metabolomics, each of which provide a wealth of data that can be used to reveal novel biomarkers and biological pathways involved in the mode-of-action of ENMs...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28165728/hepatoprotective-effect-of-%C3%AF-glutathione-in-a-murine-model-of-acetaminophen-induced-liver-toxicity
#9
Swati S More, Jaime Nugent, Ashish P Vartak, Steffan M Nye, Robert Vince
Ψ-Glutathione (ψ-GSH) is an orally bioavailable and metabolism-resistant glutathione analogue that has been shown previously to substitute glutathione in most of its biochemical roles. Described here in its entirety is the preclinical evaluation of ψ-GSH as a rescue agent for acetaminophen (APAP) overdose: an event where time is of essence. By employing a murine model, four scenarios commonly encountered in emergency medicine are reconstructed. ψ-GSH is juxtaposed against N-acetylcysteine (NAC), the sole clinically available drug, in each of the scenarios...
February 16, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28154885/endocrine-disruption-and-in-vitro-ecotoxicology-recent-advances-and-approaches
#10
Martin Wagner, Cornelia Kienle, Etiënne L M Vermeirssen, Jörg Oehlmann
Endocrine-disrupting chemicals (EDCs) are man-made compounds interfering with hormone signaling. Omnipresent in the environment, they can cause adverse effects in a wide range of wildlife. Accordingly, Endocrine Disruption is one focal area of ecotoxicology. Because EDCs induce complex response patterns in vivo via a wide range of mechanisms of action, in vitro techniques have been developed to reduce and understand endocrine toxicity. In this review we revisit the evidence for endocrine disruption in diverse species and the underlying molecular mechanisms...
February 3, 2017: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/28149262/mass-spectrometry-applications-for-toxicology
#11
Michael M Mbughuni, Paul J Jannetto, Loralie J Langman
Toxicology is a multidisciplinary study of poisons, aimed to correlate the quantitative and qualitative relationships between poisons and their physiological and behavioural effects in living systems. Other key aspects of toxicology focus on elucidation of the mechanisms of action of poisons and development of remedies and treatment plans for associated toxic effects. In these endeavours, Mass spectrometry (MS) has become a powerful analytical technique with a wide range of application used in the Toxicological analysis of drugs, poisons, and metabolites of both...
December 2016: EJIFCC
https://www.readbyqxmd.com/read/28139312/impact-of-an-emergency-short-stay-unit-on-emergency-department-performance-of-poisoned-patients
#12
Michael A Downes, James K Balshaw, Tracy M Muscat, Nicole Ritchie, Geoffrey K Isbister
OBJECTIVES: This was a before and after study which sought to assess the impact of opening an ED short stay unit (ESSU) on the ED performance of poisoned patients. METHODS: Data was collected from two groups of adult patients presenting to an ED with a tertiary referral inpatient Toxicology unit from the 2009 and 2012 calendar years, to assess the impact of the ESSU. The toxicology unit clinical database and hospital electronic medical records were interrogated for demographic, clinical and hospital flow details of presentations...
January 26, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28137240/ascidians-an-emerging-marine-model-for-drug-discovery-and-screening
#13
Rémi Dumollard, Ievgeniia Gazo, Isa D L Gomes, Lydia Besnardeau, Alex McDougall
Ascidians (tunicates; sea squirts) are marine animals which provide a source of diverse, bioactive natural products, and a model for toxicity screenings. Compounds isolated from ascidians comprise an approved anti-tumor drug and many others are potent drug leads. Furthermore, the use of invertebrate embryos for toxicological screening tests or analysis offers the possibility to image a large number of samples for high throughput screens. Ascidians are members of a sister clade to the vertebrates and make a vertebrate-like tadpole larva composed of less than 3000 cells in 18 hours...
January 29, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28125568/cluster-of-an-unusual-amnestic-syndrome-massachusetts-2012-2016
#14
Jed A Barash, Nick Somerville, Alfred DeMaria
In November 2015, a neurologist in the Boston, Massachusetts, area reported four cases of an uncommon amnestic syndrome involving acute and complete ischemia of both hippocampi, as identified by magnetic resonance imaging (MRI), to the Massachusetts Department of Public Health (MDPH) (1). A subsequent e-mail alert, generated by the Massachusetts Board of Registration in Medicine and sent to relevant medical specialists (including neurologists, neuroradiologists, and emergency physicians), resulted in the identification of 10 additional cases that had occurred during 2012-2016...
January 27, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28116024/demographics-and-fellowship-training-of-residency-leadership-in-em-a-descriptive-analysis
#15
Josh Greenstein, Ross Hardy, Jerel Chacko, Abbas Husain
INTRODUCTION: Emergency medicine (EM) fellowships are becoming increasingly numerous, and there is a growing trend among EM residents to pursue postgraduate fellowship training. Scant data have been published on the prevalence of postgraduate training among emergency physicians. We aimed to describe the prevalence and regional variation of fellowships among EM residency leadership. METHODS: We conducted an online anonymous survey that was sent to the Council of EM Residency Directors (CORD) membership in October 2014...
January 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28115648/drug-induced-taste-disorders-in-clinical-practice-and-preclinical-safety-evaluation
#16
Tao Wang, John Glendinning, Miriam Grushka, Thomas Hummel, Keith Mansfield
More than 200 medications can induce taste disorders in patients. They not only reduce quality of life for those affected, but can lead to malnutrition, severe dehydration and difficulty in maintaining a therapeutic regimen. Nevertheless, the impact of drug candidates on taste is rarely evaluated in preclinical toxicology studies during the early stage of drug development. Moreover, knowledge about how to investigate these adverse effect is scarce in the toxicology field. Here, we discuss the clinical status of drug-induced taste disorders in patients, with the goal of providing toxicologists with a broad understanding its prevalence, and how stressful and even dangerous it can be to affected patients...
January 23, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28112666/determination-of-pharmaceutical-residues-and-assessment-of-their-removal-efficiency-at-the-daugavgriva-municipal-wastewater-treatment-plant-in-riga-latvia
#17
I Reinholds, O Muter, I Pugajeva, J Rusko, I Perkons, V Bartkevics
Pharmaceutical products (PPs) belong to emerging contaminants that may accumulate along with other chemical pollutants in wastewaters (WWs) entering industrial and/or urban wastewater treatment plants (WWTPs). In the present study, the technique of ultra-high-performance liquid chromatography coupled to Orbitrap high-resolution mass spectrometry (Orbitrap-HRMS) was applied for the analysis of 24 multi-class PPs in WW samples collected at different technological stages of Daugavgriva WWTP located in Riga, Latvia...
January 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28110047/are-cuo-nanoparticles-effects-on-hemocytes-of-the-marine-scallop-chlamys-farreri-caused-by-particles-and-or-corresponding-released-ions
#18
Xuemei Sun, Bijuan Chen, Bin Xia, Qian Han, Lin Zhu, Keming Qu
Manufactured nanoparticles (NPs) have become emerging pollutants and attracted extensive concern about their potential effects on the marine environment. However, the contribution of particles and their corresponding released ions to the overall toxicity of CuO NPs is poorly understood. In this study, we investigated the toxicological effects of CuO NPs and their corresponding released ions on the hemocytes of Chlamys farreri. Both copper species induced membrane damage, and increased lysosome contents in hemocytes...
January 19, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28091758/-deaths-from-propofol-abuse-survey-of-institutes-of-forensic-medicine-in-germany-austria-and-switzerland
#19
C Maier, J Iwunna, M Tsokos, F Mußhoff
Previous references suggesting a high mortality of propofol addiction in medical personnel were mostly based on surveys of the heads of medical departments or case reports; therefore, a questionnaire was sent to 48 forensic medicine departments in Germany, Austria and Switzerland concerning the number of autopsies carried out between 2002-2112 on medical personnel with the suspicion of abuse of propofol or other analgesics. The response rate was 67%. In 16 out of the 32 responding departments 39 deaths (27 males) were observed with previous connections to anesthesiology, intensive care or emergency departments of which 22 were physicians, 13 nurses, 2 other personnel and 2 were unknown...
January 13, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/28074704/the-toxicology-of-zinc-chloride-smoke-producing-bombs-and-screens
#20
Ayman El Idrissi, Lisanne van Berkel, Nadia E Bonekamp, Diana J Z Dalemans, Marcel A G van der Heyden
CONTEXT: Zinc chloride (ZnCl2)-based smoke bombs and screens are in use since the Second World War (1939-1945). Many case descriptions on ZnCl2 smoke inhalation incidents appeared since 1945. OBJECTIVE: We provide a comprehensive overview of the clinical symptoms and underlying pathophysiology due to exposure to fumes from ZnCl2 smoke producing bombs. In addition, we give a historical overview of treatment regimens and their outcomes. METHODOLOGY: We performed a literature search on Medline, Scopus and Google Scholar databases using combinations of the following search terms "smoke bomb", "smoke screen", "ZnCl2", "intoxication", "poisoning", "case report", "HE smoke", "hexachloroethane smoke", "smoke inhalation" and "white smoke"...
March 2017: Clinical Toxicology
keyword
keyword
81331
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"