Petra Bořilová Linhartová, Ondřej Zendulka, Jaroslav Janošek, Natálie Mlčůchová, Michaela Cvanová, Zdeněk Daněk, Radek Kroupa, Ladislava Bartošová, Břetislav Lipový
To this date, there are no recommendations for personalized stress ulcer prophylaxis (SUP) in critical care that would take the patient's individual genetic predispositions into account. Of drugs used for this purpose, proton pump inhibitors (PPIs) are the first-choice drugs in intensive care unit patients. The degradation of proton pump inhibitors is mediated by cytochrome P450 (CYP) enzymes; in particular, CYP2C19 and, to a lesser extent, CYP3A4 are involved. Expression and metabolic activity of, namely in, CYP2C19 is significantly affected by single nucleotide polymorphisms, the drug metabolization rate varies greatly from ultrarapid to poor and likely influences the optimal dosage...
2022: Frontiers in Medicine