Derek J Bivona, Srikar Tallavajhala, Mohamad Abdi, Pim J A Oomen, Xu Gao, Rohit Malhotra, Andrew Darby, Oliver J Monfredi, J Michael Mangrum, Pamela Mason, Sula Mazimba, Michael Salerno, Christopher M Kramer, Frederick H Epstein, Jeffrey W Holmes, Kenneth C Bilchick
Background: Mechanisms of sex-based differences in outcomes following cardiac resynchronization therapy (CRT) are poorly understood. Objective: To use cardiac magnetic resonance (CMR) to define mechanisms of sex-based differences in outcomes after CRT and describe distinct CMR-based phenotypes of CRT candidates based on sex and non-ischemic/ischemic cardiomyopathy type. Materials and methods: In a prospective study, sex-based differences in three short-term CRT response measures [fractional change in left ventricular end-systolic volume index 6 months after CRT (LVESVI-FC), B-type natriuretic peptide (BNP) 6 months after CRT, change in peak VO2 6 months after CRT], and long-term survival were evaluated with respect to 39 baseline parameters from CMR, exercise testing, laboratory testing, electrocardiograms, comorbid conditions, and other sources...
2022: Frontiers in Cardiovascular Medicine