Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Min Li, Jianpeng Liu, Fangfei Liu, Rongbin Lv, Haowei Bai, Shuyong Liu
Objective The purpose of this study was to evaluate the prognostic significance of corrected baseline metabolic parameters in fluorodeoxyglucose positron emission tomography imaging ( 18 F-FDG PET/CT) for 3-year progression-free survival (PFS) in patients with primary diffuse large B cell lymphoma (DLBCL). Patients and Methods Retrospective clinical and pathological data were collected for 199 patients of DLBCL diagnosed between January 2018 and January 2021. All patients underwent 18 F-FDG PET/CT scans without any form of treatment...
March 2024: World Journal of Nuclear Medicine
#2
Nai-Chien Huan, Wei Lun Lee, Hema Yamini Ramarmuty, Larry Ellee Nyanti, Melody Shu Ling Tsen, Dahziela Yunus
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a revolutionary tool for the diagnosis and staging of mediastinal disorders. Nevertheless, its diagnostic capability is reduced in certain disorders such as lymphoproliferative diseases. EBUS-guided transbronchial mediastinal cryobiopsy (EBUS-TBMC) is a novel technique that can provide larger samples with preserved tissue architecture, with an acceptable safety profile. In this case report, we present a middle-aged gentleman with a huge anterior mediastinal mass and bilateral mediastinal and hilar lymphadenopathy...
April 2024: Respirology Case Reports
#3
JOURNAL ARTICLE
Zhiqiang Hu, Shuai Yuan, Yun Mou
BACKGROUND: Right-side heart mass can be found incidentally on routine transthoracic echocardiography (TTE). Accurate diagnosis of cardiac mass often requires more than one imaging method. We present a mid-age woman with non-Hodgkin lymphoma who was found to have multiple right atrial masses mimicking metastases on routine TTE, which were finally diagnosed as thrombi by multimodal cardiac imaging. CASE PRESENTATION: A 52-year-old woman was diagnosed with primary mediastinal diffuse large B cell lymphoma (DLBCL) almost six months prior...
April 1, 2024: Journal of Cardiothoracic Surgery
#4
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 28, 2024: Blood
#5
JOURNAL ARTICLE
Fereshteh Yousefirizi, Claire Gowdy, Ivan S Klyuzhin, Maziar Sabouri, Petter Tonseth, Anna R Hayden, Donald Wilson, Laurie H Sehn, David W Scott, Christian Steidl, Kerry J Savage, Carlos F Uribe, Arman Rahmim
OBJECTIVES: Accurate outcome prediction is important for making informed clinical decisions in cancer treatment. In this study, we assessed the feasibility of using changes in radiomic features over time (Delta radiomics: absolute and relative) following chemotherapy, to predict relapse/progression and time to progression (TTP) of primary mediastinal large B-cell lymphoma (PMBCL) patients. MATERIAL AND METHODS: Given the lack of standard staging PET scans until 2011, only 31 out of 103 PMBCL patients in our retrospective study had both pre-treatment and end-of-treatment (EoT) scans...
March 8, 2024: Cancers
#6
JOURNAL ARTICLE
L W Chen, J Y Li, L Fan
Primary mediastinal large B-cell lymphoma (PMBCL) is an aggressive B-cell lymphoma originating from the thymus, which has different clinical and biological characteristics from diffuse large B-cell lymphoma, NOS. PMBCL tends to occur in young women, usually presenting as a large anterior mediastinal mass. Most patients are in stage Ⅰ-Ⅱ at the time of presentation. There is no standard prognostic scoring system for PMBCL. Immunochemotherapy is commonly used in the treatment of PMBCL, but the optimal first-line treatment has not been determined, and the status of radiotherapy is controversial...
January 14, 2024: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
#7
JOURNAL ARTICLE
Marie-France Gagnon, Reid G Meyer, Eric J Weaver, Adam J Wood, Dudley A Dupuy, Sudeep J Menachery, Min Shi, Linda B Baughn, Rhett P Ketterling, Jess F Peterson
Several reports of concurrent MYC, BCL2, BCL6, and CCND1 rearrangements in high-grade B-cell lymphoma (HGBL) have been recently described. Herein, we aimed to delineate the scope of this entity through a review of HGBL with a "quadruple-hit" genetic profile identified at our institution. We performed a retrospective review (2015-2023) at our institution of B-cell lymphoma (BCL) cases that were evaluated with concurrent MYC, BCL2, and BCL6 break-apart and IGH::MYC and IGH::CCND1 dual-color dual-fusion fluorescence in situ hybridization studies...
March 24, 2024: Laboratory Medicine
#8
JOURNAL ARTICLE
Fereshteh Yousefirizi, Isaac Shiri, Joo Hyun O, Ingrid Bloise, Patrick Martineau, Don Wilson, François Bénard, Laurie H Sehn, Kerry J Savage, Habib Zaidi, Carlos F Uribe, Arman Rahmim
Manual segmentation poses a time-consuming challenge for disease quantification, therapy evaluation, treatment planning, and outcome prediction. Convolutional neural networks (CNNs) hold promise in accurately identifying tumor locations and boundaries in PET scans. However, a major hurdle is the extensive amount of supervised and annotated data necessary for training. To overcome this limitation, this study explores semi-supervised approaches utilizing unlabeled data, specifically focusing on PET images of diffuse large B-cell lymphoma (DLBCL) and primary mediastinal large B-cell lymphoma (PMBCL) obtained from two centers...
March 21, 2024: Physical and engineering sciences in medicine
#9
JOURNAL ARTICLE
Annalisa Chiappella, Beatrice Casadei, Patrizia Chiusolo, Alice Di Rocco, Silva Ljevar, Martina Magni, Piera Angelillo, Anna Maria Barbui, Ilaria Cutini, Anna Dodero, Francesca Bonifazi, Maria Chiara Tisi, Stefania Bramanti, Maurizio Musso, Mirko Farina, Massimo Martino, Mattia Novo, Giovanni Grillo, Francesca Patriarca, Giulia Zacchi, Mauro Krampera, Martina Pennisi, Eugenio Galli, Maurizio Martelli, Andrés J M Ferreri, Silvia Ferrari, Riccardo Saccardi, Anisa Bermema, Anna Guidetti, Rosalba Miceli, Pier Luigi Zinzani, Paolo Corradini
Axicabtagene ciloleucel showed efficacy for relapsed/refractory large B-cell lymphomas (LBCL), including primary mediastinal B-cell lymphomas (PMBCL); however, only few PMBCLs were reported. Aim was to evaluate efficacy and safety of axicabtagene ciloleucel in patients with PMBCL compared to those with other LBCL, enrolled in the Italian prospective observational CART-SIE study. PMBCLs (n = 70) were younger, with higher percentage of bulky and refractory disease, compared to other LBCLs (n = 190)...
March 8, 2024: Leukemia
#10
JOURNAL ARTICLE
Dasom Lee, Anmol Goyal, William L Wang, Snegha Ananth, Eric Lau, Michael S Binkley, Sushma Bharadwaj, Saurabh Dahiya
The safety and efficacy of CAR T-cell therapy are unknown in pediatric and adolescent patients with relapsed or refractory primary mediastinal large B-cell lymphoma (R/R PMBCL) which is associated with dismal prognosis. Here, we present a case report of a 16-year-old patient with R/R PMBCL treated with lisocabtagene maraleucel including correlative studies. Patient achieved complete response at 6 months without cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome. She only experienced mild cytopenias, requiring filgrastim once...
February 2024: EJHaem
#11
JOURNAL ARTICLE
Haifang Hang, Hui Zhou, Liyuan Ma
The goal of this study was to investigate the clinical characteristics, prognostic variables, and survival of patients with primary mediastinal diffuse large B cell lymphoma (PMBCL) in the rituximab era. The Surveillance, Epidemiology, and End Results (SEER) database was used to identify PMBCL patients diagnosed between 2000 and 2019. The Kaplan-Meier (K-M) technique and log-rank test were used to assess overall survival (OS) and disease-specific survival (DSS). The independent prognostic variables for OS and DSS were identified using univariate and multivariate Cox regression analysis...
February 23, 2024: Medicine (Baltimore)
#12
JOURNAL ARTICLE
Fereshteh Yousefirizi, Ivan S Klyuzhin, Joo Hyun O, Sara Harsini, Xin Tie, Isaac Shiri, Muheon Shin, Changhee Lee, Steve Y Cho, Tyler J Bradshaw, Habib Zaidi, François Bénard, Laurie H Sehn, Kerry J Savage, Christian Steidl, Carlos F Uribe, Arman Rahmim
PURPOSE: Total metabolic tumor volume (TMTV) segmentation has significant value enabling quantitative imaging biomarkers for lymphoma management. In this work, we tackle the challenging task of automated tumor delineation in lymphoma from PET/CT scans using a cascaded approach. METHODS: Our study included 1418 2-[18 F]FDG PET/CT scans from four different centers. The dataset was divided into 900 scans for development/validation/testing phases and 518 for multi-center external testing...
February 8, 2024: European Journal of Nuclear Medicine and Molecular Imaging
#13
JOURNAL ARTICLE
Ching-Fen Yang, Yu-Ting Yu, Shu-Hsien Wang, Ya-Ping Chen, Tsai-Yun Chen, Chih-Yi Hsu, L Jeffrey Medeiros, Kung-Chao Chang
BLS-type diffuse large B-cell lymphoma (DLBCL) denotes an uncommon, aggressive variant of DLBCL presenting initially in bone marrow, liver and spleen without lymphadenopathy or mass lesion. Patients with BLS-type DLBCL present frequently with haemophagocytic syndrome which often leads to early patient demise. Programmed death ligand 1 (PD-L1) plays a negative regulatory role on effector T cells and is an important target of immunotherapy. Assessment of PD-L1 expression in BLS-type DLBCL may carry therapeutic implications and provide mechanistic insights...
January 14, 2024: Pathology
#14
JOURNAL ARTICLE
Major impact of prognosis by age and sex in patients with primary mediastinal large B‑cell lymphoma.
Hsuan-Jen Shih, Ming-Chung Kuo, Tung-Liang Lin, Hsiao-Wen Kao, Jin-Hou Wu, Yu-Shin Hung, Che-Wei Ou, Yi-Jiun Su, Hung Chang
The effective prognostic factors for primary mediastinal large B-cell lymphoma (PMLBCL) vary among published studies. The aim of the present study was to explore the factors influencing the overall survival (OS) and progression-free survival (PFS) of patients with PMLBCL at a single institute in Taiwan. This retrospective study was conducted to analyze the prognostic impact of age, sex, disease stage, International Prognostic Index (IPI) score, treatment modality and initial response. A total of 72 patients with a median age of 28 years were included in the study...
February 2024: Oncology Letters
#15
JOURNAL ARTICLE
Priyanka Mishra, Manoj Prashar, Nidhin Rehman, Anamika Sinha, Deep K Raman
BACKGROUND: Primary extranodal lymphomas (pENL) are lymphomas with minimal nodal involvement and dominant extranodal disease. We aimed to study the prevalence and clinicopathological characteristics of pENL presenting at our center over 5 years from January 2015 to January 2020. METHODS: This is a cross-sectional study of pENL patients in which relevant clinical and laboratory data was collected including demography, site, stage, international prognostic index-revised, imaging findings, hematological, and biochemical parameters and comorbidities including underlying immunodeficiency...
April 17, 2023: Indian Journal of Cancer
#16
JOURNAL ARTICLE
Oren Pasvolsky, Roland L Bassett, Sassine Ghanem, Branko Cuglievan, Priti Tewari, Chitra Hosing, Samer Srour, Jeremy Ramdial, Kris M Mahadeo, Sajad Khazal, Demetrios Petropoulos, Uday Popat, Muzaffar Qazilbash, Partow Kebriaei, Richard Champlin, Elizabeth J Shpall, Yago Nieto
BACKGROUND: There is paucity of data regarding outcomes of children, adolescents and young adults (CAYA) patients with non-Hodgkin lymphoma (NHL) undergoing autologous stem cell transplantation (ASCT). METHODS: Patients aged 0-39 years undergoing first ASCT for NHL at MD Anderson Cancer Center between 2000 and 2020 were analyzed. RESULTS: Two hundred twenty-one patients were included in the analysis, 129 (58%) were male and the median age was 32 (range 6-39) years...
December 20, 2023: BMC Cancer
#17
JOURNAL ARTICLE
Daniel Noerenberg, Franziska Briest, Cornelius Hennch, Kenichi Yoshida, Raphael Hablesreiter, Yasuhide Takeuchi, Hiroo Ueno, Annette M Staiger, Marita Ziepert, Fazila Asmar, Benjamin N Locher, Erika Toth, Thomas Weber, Rose-Marie Amini, Wolfram Klapper, Maria Bouzani, Viola Poeschel, Andreas Rosenwald, Gerhard Held, Elías Campo, Naveed Ishaque, Kostas Stamatopoulos, George Kanellis, Ioannis Anagnostopoulos, Lars Bullinger, Neta Goldschmidt, Pier Luigi Zinzani, Csaba Bödör, Richard Rosenquist, Theodoros P Vassilakopoulos, German Ott, Seishi Ogawa, Frederik Damm
PURPOSE: Primary mediastinal large B-cell lymphoma (PMBCL) is a rare aggressive lymphoma predominantly affecting young female patients. Large-scale genomic investigations and genetic markers for risk stratification are lacking. PATIENTS AND METHODS: To elucidate the full spectrum of genomic alterations, samples from 340 patients with previously untreated PMBCL were investigated by whole-genome (n = 20), whole-exome (n = 78), and targeted (n = 308) sequencing. Statistically significant prognostic variables were identified using a multivariable Cox regression model and confirmed by L1/L2 regularized regressions...
February 1, 2024: Journal of Clinical Oncology
#18
JOURNAL ARTICLE
Theodoros P Vassilakopoulos, Alexia Piperidou, Zois Mellios, Evgenia Verigou, Eirini Katodritou, Christina Kalpadakis, Sotirios G Papageorgiou, Chrysovalantou Chatzidimitriou, Vassilios Prassopoulos, Marina P Siakantaris, Hara Giatra, Dimitrios Karantanis, Nikolaos Papathanasiou, Loukia Ligdi, Anastasia Kopsaftopoulou, Theoni Leonidopoulou, Vasileios Xanthopoulos, Stamatios Karakatsanis, Effimia Vrakidou, Sophia Chatziioannou, Dimitrios Drougkas, Eleftheria Hatzimichael, Gabriella Gainaru, Maria Palassopoulou, Maria Tsirogianni, Maria Kotsopoulou, Gerassimos Tsourouflis, Evangelia Skoura, Catherine Mainta, Evangelos Terpos, Christos Poziopoulos, Theodora Triantafyllou, Panayiotis Zikos, Argyro Koumarianou, Dimitra Liapi, Vassiliki Pappa, Evgenia Verrou, Panayiotis Tsirigotis, Vassiliki Labropoulou, Helen Papadaki, Ioannis Datseris, Argiris Symeonidis, Maria Bouzani, Maria Bakiri, Themis Karmiris, Maria K Angelopoulou, Phivi Rondogianni
No abstract text is available yet for this article.
November 2023: HemaSphere
#19
JOURNAL ARTICLE
Nader Kim El-Mallawany, Lisa Giulino-Roth, John M Burke, Michelle Hermiston, Carl E Allen
Pediatric non-Hodgkin lymphoma includes over 30 histologies (many with subtypes), with approximately 800 cases per year in the US, compared to >60,000 cases of adult NHL annually. Improvements in survival in pediatric and adolescent mature B cell NHL over the past 5 decades align with the overall success of the cooperative trial model with dramatic improvements in outcomes through dose escalation of chemotherapy and, more recently, targeted therapy with rituximab. Pediatric dose-intense strategies carry risks of long-term consequences, but treatment failure is nearly universally fatal...
November 2023: EJHaem
#20
REVIEW
Christian Steidl, Robert Kridel, Michael Binkley, Lindsay M Morton, Amy Chadburn
Lymphoid cancers are among the most frequent cancers diagnosed in adolescents and young adults (AYA), ranging from approximately 30%-35% of cancer diagnoses in adolescent patients (age 10-19) to approximately 10% in patients aged 30-39 years. Moreover, the specific distribution of lymphoid cancer types varies by age with substantial shifts in the subtype distributions between pediatric, AYA, adult, and older adult patients. Currently, biology studies specific to AYA lymphomas are rare and therefore insight into age-related pathogenesis is incomplete...
November 2023: EJHaem
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
