T Al Tabosh, H Liu, D Koça, M Al Tarrass, L Tu, S Giraud, L Delagrange, M Beaudoin, S Rivière, V Grobost, M Rondeau-Lutz, O Dupuis, N Ricard, E Tillet, P Machillot, A Salomon, C Picart, C Battail, S Dupuis-Girod, C Guignabert, A Desroches-Castan, S Bailly
Heterozygous activin receptor-like kinase 1 (ALK1) mutations are associated with two vascular diseases: hereditary hemorrhagic telangiectasia (HHT) and more rarely pulmonary arterial hypertension (PAH). Here, we aimed to understand the impact of ALK1 mutations on BMP9 and BMP10 transcriptomic responses in endothelial cells. Endothelial colony-forming cells (ECFCs) and microvascular endothelial cells (HMVECs) carrying loss of function ALK1 mutations were isolated from newborn HHT and adult PAH donors, respectively...
January 31, 2024: Angiogenesis