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https://www.readbyqxmd.com/read/28811176/bullous-fixed-drug-eruption-secondary-to-chlorthalidone
#1
Nathaly Cuervo-Pardo, Aurora Gonzalez-Estrada, Lyda Cuervo-Pardo, Keerthi Reddy, Alexei Gonzalez-Estrada
No abstract text is available yet for this article.
August 12, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28809439/in-silico-profiling-of-the-biological-activities-of-amaryllidaceae-alkaloids
#2
Eman Shawky
OBJECTIVES: The large number of publications about Amaryllidaceae alkaloids reflects the abundance and variety in biological activity of these alkaloids. An in-silico approach was implemented in this work to rationalize the individual alkaloids to molecular biological activity. METHODS: A database was generated containing 313 Amaryllidaceae alkaloids which were then subjected to in-silico-validated structure-based virtual screening using extra precision (XP) approach of Glide docking program...
August 15, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28809101/a-microsphere-supported-lipid-bilayer-platform-for-dna-reactions-on-a-fluid-surface
#3
Aurora Fabry-Wood, Madalyn Elise Fetrow, Carl W Brown Iii, Nicholas A Baker, Nadiezda Fernandez Oropeza, Andrew P Shreve, Gabriel A Montano, Darko Stefanovic, Matthew R Lakin, Steven W Graves
We report a versatile microsphere-supported lipid bilayer system that can serve as a general-purpose platform for implementing DNA nanotechnologies on a fluid surface. To demonstrate our platform, we implemented both toehold-mediated strand displacement (TMSD) and DNAzyme reactions, which are typically performed in solution and which are the cornerstone of DNA-based molecular logic and dynamic DNA nanotechnology, on the surface. We functionalized microspheres bearing supported lipid bilayers (µSLBs) with membrane-bound nucleic acid components...
August 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28808254/ikk2-regulates-cytokinesis-during-vertebrate-development
#4
Hongyuan Shen, Eun Myoung Shin, Serene Lee, Sinnakaruppan Mathavan, Hiromi Koh, Motomi Osato, Hyungwon Choi, Vinay Tergaonkar, Vladimir Korzh
NFκB signaling has a pivotal role in regulation of development, innate immunity, and inflammation. Ikk2 is one of the two critical kinases that regulate the NFκB signaling pathway. While the role of Ikk2 in immunity, inflammation and oncogenesis has received attention, an understanding of the role of Ikk2 in vertebrate development has been compounded by the embryonic lethality seen in mice lacking Ikk2. We find that despite abnormal angiogenesis in IKK2 zygotic mutants of zebrafish, the maternal activity of Ikk2 supports embryogenesis and maturation of fertile animals and allows to study the role of IKK2 in development...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28803183/chronic-urticaria-patient-perspective-cupp-the-first-validated-tool-for-assessing-quality-of-life-in-clinical-practice
#5
Ilaria Baiardini, Fulvio Braido, Giorgia Molinengo, Marco Caminati, MariaTeresa Costantino, Antonio Cristaudo, Mariangiola Crivellaro, Silvia Mariel Ferrucci, Rosella Gallo, Veronica Giorgis, Agostina Legori, Barbara Loera, Irene Martignago, Angelo Valerio Marzano, Aldo Morrone, Roberta Parente, Aurora Parodi, Anna Parolo, Silvia Peveri, Paolo Pigatto, Anna Radice, Erminia Ridolo, Giovanni Rolla, Chiara Roncallo, Oliviero Rossi, Eleonora Savi, Gianenrico Senna, Massimo Triggiani, Giorgio Walter Canonica
BACKGROUND: There is a need for validated tools to assess health-related quality of life (HRQoL) in routine clinical practice. OBJECTIVE: The aim of this study was to validate the Chronic Urticaria Patient Perspective (CUPP) for assessment of patients with chronic urticaria (CU) in clinical practice. METHODS: A provisional CUPP was developed from candidate items identified by following an iterative process in a retrospective analysis of 249 Chronic Urticaria Quality of Life Questionnaire questionnaires...
August 9, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28801264/vasoactive-properties-of-antihypertensive-lactoferrin-derived-peptides-in-resistance-vessels-effects-in-small-mesenteric-arteries-from-shr-rats
#6
Aurora García-Tejedor, Paloma Manzanares, María Castelló-Ruiz, Antonio Moscardó, José F Marcos, Juan B Salom
AIMS: Bovine lactoferrin (LF) hydrolysates and peptides identified thereof have shown antihypertensive effects in rat models, mainly but not exclusively by angiotensin-converting enzyme inhibition. In this study we aimed to assess the vasoactive effects and mechanisms of an ultrafiltered (<3kDa) pepsin LF hydrolysate (LFH) and a heptapeptide identified in a LF hydrolysate produced by yeast proteolysis (DPYKLRP) in peripheral resistance arteries from spontaneously hypertensive rats (SHRs)...
August 8, 2017: Life Sciences
https://www.readbyqxmd.com/read/28800395/using-chemistry-to-target-neuroblastoma
#7
Jeanne N Hansen, Xingguo Li, Y George Zheng, Louis T Lotta, Abhishek Dedhe, Nina F Schor
Neuroblastoma is a cancer of the neural crest almost exclusively seen in childhood. While children with single, small primary tumors are often cured with surgery alone, the 65% of children with neuroblastoma whose disease has metastasized have less than a 50% chance of surviving five years after diagnosis. Innovative pharmacological strategies are critically needed for these children. Efforts to identify novel targets that afford ablation of neuroblastoma with minimal toxicity to normal tissues are underway...
August 11, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28799951/surface-engineered-blood-adsorption-device-for-hyperphosphatemia-treatment
#8
Quan Shi, Michael Jolly, Marian G Mccord, Melanie S Joy
Correspondence: Melanie S. Joy, PharmD, PhD, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Mail Stop C238, Room V20-4108, 12850 East Montview Blvd, Aurora, CO 80045. Email: Melanie.Joy@ucdenver.eduThe research employed surface engineering methods to develop, optimize, and characterize a novel textile-based hemoadsorption device for hyperphosphatemia in hemodialysis-dependent end-stage kidney disease. Phosphate adsorbent fabrics (PAFs) were prepared by thermopressing alumina powders to polyester filtration fabrics and treatment with trimesic acid (TMA)...
August 8, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28797672/single-stage-conversion-from-adjustable-gastric-banding-to-sleeve-gastrectomy-or-roux-en-y-gastric-bypass-an-analysis-of-4875-patients
#9
Konstantinos Spaniolas, Andrew T Bates, Salvatore Docimo, Nabeel R Obeid, Mark A Talamini, Aurora D Pryor
BACKGROUND: The previous popularity of adjustable gastric banding (AGB), along with inconsistent long-term results, has resulted in the need for conversion to other procedures. The perioperative safety of laparoscopic sleeve gastrectomy (SG) and gastric bypass (RYGB) as single-stage conversion procedures is unclear. OBJECTIVES: To compare the early safety of SG and RYGB when performed as single-stage conversion procedures at the time of AGB removal. SETTING: Nationwide analysis of accredited centers...
July 15, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28794129/microtubule-cross-linking-activity-of-she1-ensures-spindle-stability-for-spindle-positioning
#10
Yili Zhu, Xiaojing An, Alexis Tomaszewski, Peter K Hepler, Wei-Lih Lee
Dynein mediates spindle positioning in budding yeast by pulling on astral microtubules (MTs) from the cell cortex. The MT-associated protein She1 regulates dynein activity along astral MTs and directs spindle movements toward the bud cell. In addition to localizing to astral MTs, She1 also targets to the spindle, but its role on the spindle remains unknown. Using function-separating alleles, live-cell spindle assays, and in vitro biochemical analyses, we show that She1 is required for the maintenance of metaphase spindle stability...
August 9, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28791036/ectopic-expression-of-pii-induces-stomatal-closure-in-lotus-japonicus
#11
Aurora Parlati, Vladimir T Valkov, Enrica D'Apuzzo, Ludovico M Alves, Angelo Petrozza, Stephan Summerer, Alex Costa, Francesco Cellini, Alain Vavasseur, Maurizio Chiurazzi
The PII protein in plants has been associated to many different tissue specialized roles concerning the Nitrogen assimilation pathways. We report here the further characterization of L. japonicus transgenic lines overexpressing the PII protein encoded by the LjGLB1 gene that is strongly expressed in the guard cells of Lotus plants. Consistently with a putative role played by PII in that specific cellular context we have observed an alteration of the patterns of stomatal movement in the overexpressing plants...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28778014/emissions-of-brominated-compounds-and-polycyclic-aromatic-hydrocarbons-during-pyrolysis-of-e-waste-debrominated-in-subcritical-water
#12
Aurora Soler, Juan A Conesa, Nuria Ortuño
Degradation of brominated flame retardants present in printed circuit boards (PCBs) was tested using subcritical water in a high pressure reactor. Debromination experiments were carried out in a batch stirred reactor at three different temperatures (225 °C, 250 °C and 275 °C) keeping a solid to liquid (S/L) ratio of PCB:water = 1:5 during 180 min. Results indicated that debromination efficiency was increased with temperature (18.5-63.6% of bromine present in the original PCB was removed). Thermal decomposition of the debrominated materials was studied and compared with that of the original PCB...
July 30, 2017: Chemosphere
https://www.readbyqxmd.com/read/28777595/direct-extraction-of-excitation-energies-from-ensemble-density-functional-theory
#13
Zeng-Hui Yang, Aurora Pribram-Jones, Kieron Burke, Carsten A Ullrich
A very specific ensemble of ground and excited states is shown to yield an exact formula for any excitation energy as a simple correction to the energy difference between orbitals of the Kohn-Sham ground state. This alternative scheme avoids either the need to calculate many unoccupied levels as in time-dependent density functional theory (TDDFT) or the need for many self-consistent ensemble calculations. The symmetry-eigenstate Hartree-exchange (SEHX) approximation yields results comparable to standard TDDFT for atoms...
July 21, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28771443/ard1-mediated-aurora-kinase-a%C3%A2-acetylation-promotes-cell-proliferation-and-migration
#14
Tam Thuy Lu Vo, Ji-Hyeon Park, Ji Hae Seo, Eun Ji Lee, Hoon Choi, Sung-Jin Bae, Hoang Le, Sunho An, Hye Shin Lee, Hee-Jun Wee, Kyu-Won Kim
Aurora kinase A (AuA) is a prerequisite for centrosome maturation, separation, and mitotic spindle assembly, thus, it is essential for cell cycle regulation. Overexpression of AuA is implicated in poor prognosis of many types of cancer. However, the regulatory mechanisms underlying the functions of AuA are still not fully understood. Here, we report that AuA colocalizes with arrest defective protein 1 (ARD1) acetyltransferase during cell division and cell migration. Additionally, AuA is acetylated by ARD1 at lysine residues at positions 75 and 125...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28768204/single-cell-landscape-of-transcriptional-heterogeneity-and-cell-fate-decisions-during-mouse-early-gastrulation
#15
Hisham Mohammed, Irene Hernando-Herraez, Aurora Savino, Antonio Scialdone, Iain Macaulay, Carla Mulas, Tamir Chandra, Thierry Voet, Wendy Dean, Jennifer Nichols, John C Marioni, Wolf Reik
The mouse inner cell mass (ICM) segregates into the epiblast and primitive endoderm (PrE) lineages coincident with implantation of the embryo. The epiblast subsequently undergoes considerable expansion of cell numbers prior to gastrulation. To investigate underlying regulatory principles, we performed systematic single-cell RNA sequencing (seq) of conceptuses from E3.5 to E6.5. The epiblast shows reactivation and subsequent inactivation of the X chromosome, with Zfp57 expression associated with reactivation and inactivation together with other candidate regulators...
August 1, 2017: Cell Reports
https://www.readbyqxmd.com/read/28766886/small-cell-lung-carcinoma-cell-line-screen-of-etoposide-carboplatin-plus-a-third-agent
#16
Beverly A Teicher, Thomas Silvers, Michael Selby, Rene Delosh, Julie Laudeman, Chad Ogle, Russell Reinhart, Ralph Parchment, Julia Krushkal, Dmitriy Sonkin, Larry Rubinstein, Joel Morris, David Evans
The SCLC combination screen examined a 9-point concentration response of 180 third agents, alone and in combination with etoposide/carboplatin. The predominant effect of adding a third agent to etoposide/carboplatin was additivity. Less than additive effects occurred frequently in SCLC lines sensitive to etoposide/carboplatin. In SCLC lines with little or no response to etoposide/carboplatin, greater than additive SCLC killing occurred over the entire spectrum of SCLC lines but never occurred in all SCLC lines...
August 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28766236/the-impact-of-onabotulinumtoxina-on-severe-headache-days-preempt-56-week-pooled-analysis
#17
Manjit Matharu, Rashmi Halker, Patricia Pozo-Rosich, Ronald DeGryse, Aubrey Manack Adams, Sheena K Aurora
BACKGROUND: OnabotulinumtoxinA has been shown to reduce headache-days among patients with chronic migraine (CM). The objective of this analysis was to determine whether onabotulinumtoxinA has an impact on headache-day severity in patients with CM among those patients who were deemed non-responders based on reduction in the frequency of headache days alone. METHODS: Data from the Phase 3 REsearch Evaluating Migraine Prophylaxis Therapy (PREEMPT) clinical trial program (a 24-week, 2-treatment cycle, double-blind, randomized, placebo-controlled, parallel-group phase, followed by a 32-week, 3-treatment cycle, open-label phase) were pooled for analysis...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28765278/the-peroxisomal-matrix-protein-translocon-is-a-large-cavity-forming-protein-assembly-into-which-pex5-protein-enters-to-release-its-cargo
#18
Ana F Dias, Tony A Rodrigues, Ana G Pedrosa, Aurora Barros-Barbosa, Tânia Francisco, Jorge E Azevedo
A remarkable property of the machinery for import of peroxisomal matrix proteins is that it can accept already folded proteins as substrates. This import involves binding of newly synthesized proteins by cytosolic peroxisomal biogenesis factor 5 (PEX5), followed by insertion of the PEX5-cargo complex into the peroxisomal membrane at the docking/translocation module (DTM). However, how these processes occur remains largely unknown. Here, we used truncated PEX5 molecules to probe the DTM architecture. We found that the DTM can accommodate a larger number of truncated PEX5 molecules comprising amino acid residues 1-197 than full-length PEX5 molecules...
August 1, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28764929/inhibition-of-aurora-kinase-a-induces-necroptosis-in-pancreatic-carcinoma
#19
Yangchun Xie, Shan Zhu, Meizuo Zhong, Minghua Yang, Xiaofan Sun, Jinbao Liu, Guido Kroemer, Michael Lotze, Herbert J Zeh, Rui Kang, Daolin Tang
BACKGROUND & AIMS: Induction of non-apoptotic cell death could be an approach to eliminate apoptosis-resistant tumors. We investigated necroptosis-based therapies in mouse models of pancreatic ductal adenocarcinoma cancer (PDAC). METHODS: We screened 273 commercially available kinase inhibitors for cytotoxicity against a human PDAC cell line (PANC1). We evaluated the ability of the aurora kinase inhibitor CCT137690 to stimulate necroptosis in PDAC cell lines (PANC1, PANC2...
July 29, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28764276/can-unilateral-pityriasis-rosea-be-considered-a-form-of-superimposed-lateralized-exanthem
#20
Francesco Drago, Giulia Ciccarese, Aurora Parodi
No abstract text is available yet for this article.
June 2017: Journal of Clinical and Diagnostic Research: JCDR
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