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https://www.readbyqxmd.com/read/29789272/psodisk-is-a-reliable-intuitive-instrument-for-the-evaluation-of-psychological-distress-which-strongly-correlates-with-dlqi-a-preliminary-study
#1
Emanuele Cozzani, Dennis Linder, Martina Burlando, Fabio Gallo, Francesca Sampogna, Marco Bruzzone, Carlotta Tacchino, Francesco Drago, Aurora Parodi
BACKGROUND: PSOdisk is a 10-item visual instrument, aimed at assessing the burden of disease in patients with psoriasis. OBJECTIVES: To compare PSOdisk with a scientifically validated questionnaire, the Dermatology Life Quality Index (DLQI), and asses both tools in relation to Psoriasis Severity Index (PASI) and patient acceptance. MATERIALS & METHODS: Fifty patients with cutaneous (PSO) and/or arthritic psoriasis (PSA) were recruited...
May 23, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29787386/comparison-of-tracheal-intubation-conditions-in-operating-room-and-intensive-care-unit-a-prospective-observational-study
#2
Manuel Taboada, Patricia Doldan, Andrea Calvo, Xavier Almeida, Esteban Ferreiroa, Aurora Baluja, Agustin Cariñena, Paula Otero, Valentin Caruezo, Alberto Naveira, Pablo Otero, Julian Alvarez
BACKGROUND: Tracheal intubation is a common intervention in the operating room and in the intensive care unit. The authors hypothesized that tracheal intubation using direct laryngoscopy would be associated with worse intubation conditions and more complications in the intensive care unit compared with the operating room. METHODS: The authors prospectively evaluated during 33 months patients who were tracheally intubated with direct laryngoscopy in the operating room, and subsequently in the intensive care unit (within a 1-month time frame)...
May 22, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29782877/analysis-of-spontaneous-resolution-of-cytomegalovirus-replication-after-transplantation-in-cmv-seropositive-patients-with-pretransplant-cd8-ifng-response
#3
Aurora Páez-Vega, Antonio Poyato, Alberto Rodriguez-Benot, Lluis Guirado, Jesús Fortún, Oscar Len, Edson Abdala, María C Fariñas, Elisa Cordero, Carmen de Gracia, Domingo Hernández, Rafael González, Julián Torre-Cisneros, Sara Cantisán
This prospective study evaluates whether CMV-seropositive (R+) transplant patients with pretransplant CD8+IFNG+ T-cell response to cytomegalovirus (CMV) (CD8+IFNG+ response) can spontaneously clear the CMV viral load without requiring treatment. A total of 104 transplant patients (kidney/liver) with pretransplant CD8+IFNG+ response were evaluable. This response was determined using QuantiFERON-CMV assay. The incidence of CMV replication and disease was 45.2% (47/104) and 6.7% (7/104), respectively. Of the total patients, 77...
May 18, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29780443/separase-inhibitor-sepin-1-inhibits-foxm1-expression-and-breast-cancer-cell-growth
#4
Nenggang Zhang, Debananda Pati
Sepin-1, a potent non-competitive inhibitor of separase, inhibits cancer cell growth, but the mechanisms of Sepin-1-mediated growth inhibition are not fully understood. Here we report that Sepin-1 hinders growth of breast cancer cells, cell migration, and wound healing. Inhibition of cell growth induced by Sepin-1 in vitro doesn't appear to be through apoptosis but rather due to growth inhibition. Following Sepin-1 treatment caspases 3 and 7 are not activated and Poly (ADP-ribose) polymerase (Parp) is not cleaved...
2018: Journal of Cancer Science & Therapy
https://www.readbyqxmd.com/read/29775399/dolutegravir-and-rilpivirine-for-the-maintenance-treatment-of-virologically-suppressed-hiv-1-infection
#5
Jose L Casado, Marta Monsalvo, Aurora M Rojo, María Fontecha, Miguel A Rodriguez-Sagrado
Triple combinations of antiretroviral (ART) drugs are the standard treatment for HIV infection, but the challenges include long-term side effects, high costs, and adherence. The recent advent of potent and well tolerated ART has renewed the interest for newer ART strategies. A dual regimen with the combination of dolutegravir (DTG) and rilpivirine (RPV), two well tolerated, metabolic-friendly, and potent drugs could offer additional benefits. Areas covered: A review of recent randomized trials and observational cohorts concerning the use of a dual therapy with DTG plus RPV as a switching strategy in patients with viral suppression...
May 18, 2018: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/29775089/detection-of-perimacular-red-dots-and-blots-when-screening-for-diabetic-retinopathy-refer-or-not-refer
#6
Anatolie Baltatescu, Elio Striglia, Marina Trento, Aurora Mazzeo, Franco Cavallo, Lorena Charrier, Massimo Porta
PURPOSE: Detection of microaneurysms and/or microhaemorrhages near the fovea when screening for diabetic retinopathy poses a problem because referral to retinal specialists may alarm patients and unnecessarily burden ophthalmologists. METHODS: Six-month prospective study of patients found to have minimal red lesions within one disc diameter of the fovea when screened for diabetic retinopathy. Two 45° digital photographs, one centred on the macula and the other nasal including the optic disc, were taken for each eye...
May 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29773261/perioperative-transfusion-management-in-gastric-cancer-surgery-analysis-of-the-spanish-subset-of-the-eurecca-oesophago-gastric-cancer-registry
#7
Javier Osorio, Carlos Jericó, Coro Miranda, Elisenda Garsot, Alexis Luna, Mónica Miró, Maite Santamaría, Eva Artigau, Joaquín Rodríguez-Santiago, Sandra Castro, Josep Feliu, Aurora Aldeano, Carles Olona, Dulce Momblan, David Ruiz, Gonzalo Galofré, Inmaculada Pros, Xabier García-Albéniz, Miguel Lozano, Manuel Pera
INTRODUCTION: This study evaluated allogenic packed red blood cell (aPRBC) transfusion rates in patients undergoing resection for gastric cancer and the implementation of blood-saving protocols (BSP). METHODS: Retrospective study of all gastric cancer patients operated on with curative intent in Catalonia and Navarra (2011-2013) and included in the Spanish subset of the EURECCA Oesophago-Gastric Cancer Registry. Hospitals with BSP were defined as those with a preoperative haemoglobin (Hb) optimisation circuit associated with restrictive transfusion strategies...
May 14, 2018: Cirugía Española
https://www.readbyqxmd.com/read/29771033/-the-effects-and-expression-of-survivin-and-aurora-b-in-laryngeal-carcinoma
#8
C H Hu, W H Wang, Q Wang, X S He
Objective: The aim of this study is to investigate the relationship between the expression of Survivin and Aurora-b in laryngeal carcinoma and its clinical and pathological features, and to determine the possibility of Survivin and Aurora-b being a biomarker in laryngeal carcinoma diagnosis or being an predictor of overall survival (OS) in laryngeal carcinoma patients underwent surgical resection. Method: Eighty-six cases of laryngeal carcinoma tissues diagnosed by pathology were collected, and 86 cases of adjacent tissues and 22 cases of normal tissues were selected as control...
May 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29769642/high-resolution-imaging-of-myeloperoxidase-activity-sensors-in-human-cerebrovascular-disease
#9
Youssef Z Wadghiri, Dung Minh Hoang, Anita Leporati, Matthew J Gounis, Aurora Rodríguez-Rodríguez, Mary L Mazzanti, John P Weaver, Ajay K Wakhloo, Peter Caravan, Alexei A Bogdanov
Progress in clinical development of magnetic resonance imaging (MRI) substrate-sensors of enzymatic activity has been slow partly due to the lack of human efficacy data. We report here a strategy that may serve as a shortcut from bench to bedside. We tested ultra high-resolution 7T MRI (µMRI) of human surgical histology sections in a 3-year IRB approved, HIPAA compliant study of surgically clipped brain aneurysms. µMRI was used for assessing the efficacy of MRI substrate-sensors that detect myeloperoxidase activity in inflammation...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29769406/spindle-assembly-disruption-and-cancer-cell-apoptosis-with-a-cltc-binding-compound
#10
Michael J Bond, Marina Bleiler, Lauren E Harrison, Eric W Scocchera, Masako Nakanishi, Narendran G-Dayanandan, Santosh Keshipeddy, Daniel W Rosenberg, Dennis L Wright, Charles Giardina
AK3 compounds are mitotic-arrest agents that induce high levels of γH2AX during mitosis and apoptosis following release from arrest. We synthesized a potent AK3 derivative, AK306, that induced arrest and apoptosis of the HCT116 colon cancer cell line with an EC50 of ~50 nM. AK306 was active on a broad spectrum of cancer cell lines with total growth inhibition values ranging from ~25 nM to 25 µM. Using biotin and BODIPY-linked derivatives of AK306, binding to clathrin heavy chain (CLTC/CHC) was observed, a protein with roles in endocytosis and mitosis...
May 16, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29767917/puerperae-bonding-with-their-children-and-labor-experiences
#11
Lara Helk Souza, Zaida Aurora Sperli Geraldes Soler, Maria de Lourdes Sperli Geraldes Santos, Natália Sperli Geraldes Marin Dos Santos Sasaki
OBJECTIVES: To analyze the degree of bonding of puerperae with their babies, both in isolation and associated with experiences during and after labor. METHODS: A cross-sectional study carried out among 200 puerperae in São José do Rio Preto, Brazil. To evaluate the mother-child bond, we used the Mother-to-Infant Bonding Scale (MIBS). RESULTS: The mean age of puerperae was 26.4 years; most women were white (60.0%), were married (87.5%), and had an elementary education (51...
October 2017: Investigación y Educación en Enfermería
https://www.readbyqxmd.com/read/29766305/evaluation-of-vte-prophylaxis-and-the-impact-of-alternate-regimens-on-post-operative-bleeding-and-thrombotic-complications-following-bariatric-procedures
#12
Maria S Altieri, Jie Yang, Janos Hajagos, Konstantinos Spaniolas, Jihye Park, Antonios P Gasparis, Andrew T Bates, Salvatore Docimo, Mark Talamini, A Laurie Shroyer, Aurora D Pryor
BACKGROUND: Studies examining utilization and impact of venous thromboembolism (VTE) chemoprophylaxis for patients undergoing bariatric surgery are limited. Determination of the optimal prophylactic regimen to minimize complications is crucial. METHODS: The Cerner Health Facts database from 2003 to 2013 was queried using ICD-9 codes to identify patients undergoing laparoscopic sleeve gastrectomy (LSG) and Roux-en-Y gastric bypass (RYGB). VTE chemoprophylaxis regimens were divided into pre-operative alone (PreP), post-operative alone (PostP), both pre-operative and post-operative (PPP), or no prophylaxis (NP)...
May 15, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29764992/aurora-b-opposes-pp1-function-in-mitosis-by-phosphorylating-the-conserved-pp1-binding-rvxf-motif-in-pp1-regulatory-proteins
#13
Isha Nasa, Scott F Rusin, Arminja N Kettenbach, Greg B Moorhead
Protein phosphatase 1 (PP1) is a highly conserved protein phosphatase that performs most of the serine- and threonine-dephosphorylation reactions in eukaryotes and opposes the actions of a diverse set of serine and threonine (Ser-Thr) protein kinases. PP1 gains substrate specificity through binding to a large number (>200) of regulatory proteins that control PP1 localization, activity, and interactions with substrates. PP1 recognizes the well-characterized RVxF binding motif that is present in many of these regulatory proteins, thus generating a multitude of distinct PP1 holoenzymes...
May 15, 2018: Science Signaling
https://www.readbyqxmd.com/read/29764989/global-assessment-of-its-network-dynamics-reveals-that-the-kinase-plk1-inhibits-the-phosphatase-pp6-to-promote-aurora-a-activity
#14
Arminja N Kettenbach, Kate A Schlosser, Scott P Lyons, Isha Nasa, Jiang Gui, Mark E Adamo, Scott A Gerber
Polo-like kinase 1 (Plk1) is an essential protein kinase that promotes faithful mitotic progression in eukaryotes. The subcellular localization and substrate interactions of Plk1 are tightly controlled and require its binding to phosphorylated residues. To identify phosphorylation-dependent interactions within the Plk1 network in human mitotic cells, we performed quantitative proteomics on HeLa cells cultured with kinase inhibitors or expressing a Plk1 mutant that was deficient in phosphorylation-dependent substrate binding...
May 15, 2018: Science Signaling
https://www.readbyqxmd.com/read/29764941/a-trypanosome-specific-protein-cooperates-with-the-cif1-protein-to-promote-cytokinesis-in-trypanosoma-brucei
#15
Yasuhiro Kurasawa, Huiqing Hu, Qing Zhou, Ziyin Li
Cytokinesis, the terminal step in cell division, in the protist human pathogen Trypanosoma brucei occurs along the longitudinal axis from the anterior tip of the new flagellum attachment zone (FAZ) towards the posterior cell tip. This process is regulated by a signaling cascade composed of the Polo-like kinase homolog TbPLK, the Aurora B kinase homolog TbAUK1, and the trypanosome-specific CIF1-CIF2 protein complex. However, the regulatory mechanism and the signaling pathway for this unusual mode of cytokinesis remain poorly understood...
May 15, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29764757/synthesis-and-profiling-of-a-3-aminopyridin-2-one-based-kinase-targeted-fragment-library-identification-of-3-amino-5-pyridin-4-yl-pyridin-2-1h-one-scaffold-for-monopolar-spindle-1-mps1-and-aurora-kinases-inhibition
#16
Daren Fearon, Isaac M Westwood, Rob L M van Montfort, Richard Bayliss, Keith Jones, Vassilios Bavetsias
Screening a 3-aminopyridin-2-one based fragment library against a 26-kinase panel representative of the human kinome identified 3-amino-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2(1H)-one (2) and 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one (3) as ligand efficient inhibitors of the mitotic kinase Monopolar Spindle 1 (MPS1) and the Aurora kinase family. These kinases are well recognised as attractive targets for therapeutic intervention for treating cancer. Elucidation of the binding mode of these fragments and their analogues has been carried out by X-ray crystallography...
April 17, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29764563/deubiquitinase-usp35-as-a-novel-mitotic-regulator-via-maintenance-of-aurora-b-stability
#17
Jinyoung Park, Eun Joo Song
Aurora B is an important kinase involved in dynamic cellular events in mitosis. Aurora B activity is controlled by several post-translational modifications (PTMs). Among them, E3 ubiquitin ligase-mediated ubiquitination plays crucial roles in controlling the relocation and degradation of Aurora B. Aurora B, ubiquitinated by different E3 ligases, moves to the exact site for its mitotic function during metaphase-anaphase transition and is then degraded for cell cycle progression at the end of mitosis. However, how the stability of Aurora B is maintained until its degradation has been poorly understood...
May 16, 2018: BMB Reports
https://www.readbyqxmd.com/read/29760449/aurora-kinase-a-aurka-interaction-with-wnt-and-ras-mapk-signalling-pathways-in-colorectal-cancer
#18
Annika Jacobsen, Linda J W Bosch, Sanne R Martens-de Kemp, Beatriz Carvalho, Anke H Sillars-Hardebol, Richard J Dobson, Emanuele de Rinaldis, Gerrit A Meijer, Sanne Abeln, Jaap Heringa, Remond J A Fijneman, K Anton Feenstra
Hyperactivation of Wnt and Ras-MAPK signalling are common events in development of colorectal adenomas. Further progression from adenoma-to-carcinoma is frequently associated with 20q gain and overexpression of Aurora kinase A (AURKA). Interestingly, AURKA has been shown to further enhance Wnt and Ras-MAPK signalling. However, the molecular details of these interactions in driving colorectal carcinogenesis remain poorly understood. Here we first performed differential expression analysis (DEA) of AURKA knockdown in two colorectal cancer (CRC) cell lines with 20q gain and AURKA overexpression...
May 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29760389/aurora-a-dependent-cenp-a-phosphorylation-at-inner-centromeres-protects-bioriented-chromosomes-against-cohesion-fatigue
#19
Grégory Eot-Houllier, Laura Magnaghi-Jaulin, Géraldine Fulcrand, François-Xavier Moyroud, Solange Monier, Christian Jaulin
Sustained spindle tension applied to sister centromeres during mitosis eventually leads to uncoordinated loss of sister chromatid cohesion, a phenomenon known as "cohesion fatigue." We report that Aurora A-dependent phosphorylation of serine 7 of the centromere histone variant CENP-A (p-CENP-AS7) protects bioriented chromosomes against cohesion fatigue. Expression of a non-phosphorylatable version of CENP-A (CENP-AS7A) weakens sister chromatid cohesion only when sister centromeres are under tension, providing the first evidence of a regulated mechanism involved in protection against passive cohesion loss...
May 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29756420/multiple-arterial-aneurysms-do-not-forget-syphilitic-etiology
#20
Francesco Drago, Giulia Merlo, Fiammetta Monacelli, Aurora Parodi
No abstract text is available yet for this article.
May 11, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
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