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https://www.readbyqxmd.com/read/29147626/functional-t-cells-targeting-tumor-associated-antigens-are-predictive-for-recurrence-free-survival-of-patients-with-radically-operated-non-small-cell-lung-cancer
#1
Seyer Safi, Yoshikane Yamauchi, Anchana Rathinasamy, Slava Stamova, Martin Eichhorn, Arne Warth, Geraldine Rauch, Hendrik Dienemann, Hans Hoffmann, Philipp Beckhove
In this prospective study, we examined postoperative follow-up and preoperative IFN-γ T cell responses against 14 non-small cell lung cancer (NSCLC)-associated antigens in the blood of 51 patients with NSCLC, 7 patients with benign pulmonary tumors, and 10 tumor-free patients by enzyme-linked immunospot assay. The phenotype and function of T cells specific for tumor-associated antigens (TAAs) in the blood or tumor tissue of 9 NSCLC patients were characterized in detail using TNF-α, IL-2, and IFN-γ cytokine capture assays...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29147452/the-effect-of-aurora-kinase-inhibitor-on-adhesion-and-migration-in-human-breast-cancer-cells-and-clinical-implications
#2
Huishan Zhao, Sioned Owen, Eleri L Davies, Wen G Jiang, Tracey A Martin
Background: The Aurora kinase family is comprised of highly conserved serine/threonine protein kinases that are known to be crucial in the regulation of the cell cycle. Aberrant expression of Aurora kinases has been demonstrated in certain malignancies. We aimed to examine the expression of Aurora kinases in human breast cancer tissues and to investigate the cellular impact of Aurora kinases inhibitor on breast cancer cells. Methods: The expression of Aurora kinase A/B/C was individually examined in tumor specimens (n = 106) and normal tissues (n = 29) from breast cancer patients using quantitative real-time PCR (Q-PCR) and immunohistochemistry...
October 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29146887/targeted-therapy-of-gastroenteropancreatic-neuroendocrine-tumours-preclinical-strategies-and-future-targets
#3
Elke Tatjana Aristizabal Prada, Christoph J Auernhammer
Molecular targeted therapy of advanced neuroendocrine tumours (NETs) of the gastroenteropancreatic (GEP) system currently encompasses approved therapy with the mTOR-inhibitor everolimus and the multi-tyrosinkinase inhibitor sunitinib. However clinical efficacy of these treatment strategies is limited by low objective response rates and limited progression free survival due to tumor resistance. Further novel strategies for molecular targeted therapy of NETs of the GEP-system are needed. This paper reviews preclinical research models and signaling pathways in NETs of the GEP-system...
November 16, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29144097/simultaneous-occurrence-of-hand-foot-and-mouth-disease-and-pityriasis-rosea
#4
Francesco Drago, Giulia Ciccarese, Margherita Cioni, Lodovica Gariazzo, Aurora Parodi
No abstract text is available yet for this article.
November 16, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29142322/bilateral-5%C3%A2-hz-transcranial-alternating-current-stimulation-on-fronto-temporal-areas-modulates-resting-state-eeg
#5
Aurora D'Atri, Claudia Romano, Maurizio Gorgoni, Serena Scarpelli, Valentina Alfonsi, Michele Ferrara, Fabio Ferlazzo, Paolo Maria Rossini, Luigi De Gennaro
Rhythmic non-invasive brain stimulations are promising tools to modulate brain activity by entraining neural oscillations in specific cortical networks. The aim of the study was to assess the possibility to influence the neural circuits of the wake-sleep transition in awake subjects via a bilateral transcranial alternating current stimulation at 5 Hz (θ-tACS) on fronto-temporal areas. 25 healthy volunteers participated in two within-subject sessions (θ-tACS and sham), one week apart and in counterbalanced order...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29141582/a-novel-interaction-between-kinase-activities-in-regulation-of-cilia-formation
#6
Nicole DeVaul, Katerina Koloustroubis, Rong Wang, Ann O Sperry
BACKGROUND: The primary cilium is an extension of the cell membrane that encloses a microtubule-based axoneme. Primary cilia are essential for transmission of environmental cues that determine cell fate. Disruption of primary cilia function is the molecular basis of numerous developmental disorders. Despite their biological importance, the mechanisms governing their assembly and disassembly are just beginning to be understood. Cilia growth and disassembly are essential events when cells exit and reenter into the cell cycle...
November 15, 2017: BMC Cell Biology
https://www.readbyqxmd.com/read/29133983/concomitant-psychiatric-symptoms-and-impaired-quality-of-life-in-women-with-cervical-cancer-a-critical-review
#7
REVIEW
Stephanie Klügel, Caroline Lücke, Aurora Meta, Meike Schild-Suhren, Eduard Malik, Alexandra Philipsen, Helge Ho Müller
Our aim was to summarize the current relevant literature on concomitant psychiatric symptoms with a focus on anxiety/depression in a population with gynecologic cancer; to identify the predictors, associated factors, and prevention strategies of psychiatric disorders; to examine psychiatric disorders in a population with recurrent gynecologic cancer; and to describe the limitations of the literature and future research areas. Little is known about attending psychiatric disorders in patients with gynecologic and other malignant diseases like cervical or breast cancer...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/29131637/copper-catalyzed-enantioselective-synthesis-of-%C3%AE-boron-%C3%AE-amino-esters
#8
Aurora López, Timothy B Clark, Alejandro Parra, Mariola Tortosa
In this report, the enantioselective, copper-catalyzed borylation of β-amidoacrylates is disclosed. A broad variety of biologically important α-aminoboronates has been prepared with consistently high levels of enantiocontrol using an inexpensive copper catalyst and a commercially available chiral ligand. The method can be applied to the synthesis of novel boron-containing dipeptides and hemiboronates.
November 13, 2017: Organic Letters
https://www.readbyqxmd.com/read/29129699/deguelin-an-aurora-b-kinase-inhibitor-exhibits-potent-anti-tumor-effect-in-human-esophageal-squamous-cell-carcinoma
#9
Xinfang Yu, Qi Liang, Wenbin Liu, Li Zhou, Wei Li, Haidan Liu
Aurora B kinase has emerged as a key regulator of mitosis and deregulation of Aurora B activity is closely related to the development and progression of human cancers. In the present study, we found that Aurora B is overexpressed in human esophageal squamous cell carcinoma (ESCC), high levels of Aurora B protein were associated with a worse overall survival rate in ESCC patients. Depleting of Aurora B blunted the malignant phenotypes in ESCC cells. Importantly, we demonstrated that a natural compound, deguelin, has a profound anti-tumor effect on ESCC via inhibiting Aurora B activity...
November 3, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29129589/behavior-of-detoxifying-enzymes-of-aedes-aegypti-exposed-to-girgensohnine-alkaloid-analog-and-cymbopogon-flexuosus-essential-oil
#10
Aurora L Carreño Otero, Angela Maria Palacio-Cortés, Mario Antonio Navarro-Silva, Vladimir V Kouznetsov, Jonny E Duque L
Because mosquito control depend on the use of commercial insecticides and resistance has been described in some of them, there is a need to explore new molecules no resistant. In vivo effects of girgensohnine analog 2-(3,4-dimethoxyphenyl)-2-(piperidin-1-yl)acetonitrile DPPA and Cymbopogon flexuosus essential oil CFEO, on the detoxifying enzymes acetylcholinesterase (AChE), glutathione-S-transferase (GST), nonspecific esterases (α- and β-), mixed function oxidases (MFO) and p-NPA esterases were evaluated on a Rockefeller (Rock) and wild Aedes aegypti population from Santander, Colombia (WSant)...
November 10, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29128541/a-pegylated-platelet-free-plasma-hydrogel-based-composite-scaffold-enables-stable-vascularization-and-targeted-cell-delivery-for-volumetric-muscle-loss
#11
Amit Aurora, Nicole Wrice, Thomas J Walters, Robert J Christy, Shanmugasundaram Natesan
Extracellular matrix (ECM) scaffolds are being used for the clinical repair of soft tissue injuries. Although improved functional outcomes have been reported, ECM scaffolds show limited tissue specific remodeling response with concomitant deposition of fibrotic tissue. One plausible explanation is the regression of blood vessels which may be limiting the diffusion of oxygen and nutrients across the scaffold. Herein we develop a composite scaffold as a vasculo-inductive platform by integrating PEGylated platelet free plasma (PFP) hydrogel with a muscle derived ECM scaffold (m-ECM)...
November 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29126912/agbl2-promotes-cancer-cell-growth-through-irgm-regulated-autophagy-and-enhanced-aurora-a-activity-in-hepatocellular-carcinoma
#12
Li-Li Wang, Xiao-Han Jin, Mu-Yan Cai, Hai-Gang Li, Jie-Wei Chen, Feng-Wei Wang, Chen-Yuan Wang, Wei-Wei Hu, Fang Liu, Dan Xie
AGBL2 has been reported to catalyze α-tubulin detyrosination, by which it promotes tumorigenesis and cancer progression. However, its potential role in the pathogenesis of hepatocellular carcinoma (HCC) has not been revealed yet. In the present study, AGBL2 was frequently found being overexpressed in HCC tissues and cell lines. In a large cohort of clinical HCC tissues, high expression of AGBL2 was positively associated with tumor size, tumor multiplicity and advanced clinical stage (p<0.05), and it was an independent prognostic factor for HCC patients...
November 7, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29126304/sdhc-promoter-methylation-a-novel-pathogenic-mechanism-in-parasympathetic-paragangliomas
#13
Cristóbal Bernardo-Castiñeira, Nuria Valdés, Marta I Sierra, Inés Sáenz-de-Santa-María, Gustavo F Bayón, Raúl F Perez, Agustín F Fernández, Mario F Fraga, Aurora Astudillo, Rafael Menéndez, Belén Fernández, Maribel Del Olmo, Carlos Suarez, María-Dolores Chiara
Context: Germline mutations in the succinate dehydrogenase A, B, C, and D genes (collectively, SDHx) predispose to the development of paragangliomas (PGLs) arising at the parasympathetic or sympathetic neuroendocrine systems. SDHx mutations cause absence of tumoral immunostaining for SDHB. However, negative SDHB-immunostaining has also been found in a subset of PGLs that lack SDHx mutations. Settings: Here, we report the comprehensive molecular characterization of one such a tumor of parasympathetic origin compared with healthy paraganglia and other PGLs with or without SDHx mutations...
November 3, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29122914/pulmonary-function-deficits-in-newborn-screened-infants-with-cystic-fibrosis-managed-with-standard-uk-care-are-mild-and-transient
#14
Gwyneth Davies, Janet Stocks, Lena P Thia, Ah-Fong Hoo, Andrew Bush, Paul Aurora, Lucy Brennan, Simon Lee, Sooky Lum, Philippa Cottam, Joanne Miles, Jane Chudleigh, Jane Kirkby, Ian M Balfour-Lynn, Siobhán B Carr, Colin Wallis, Hilary Wyatt, Angie Wade
With the advent of novel designer molecules for cystic fibrosis (CF) treatment, there is huge need for early-life clinical trial outcomes, such as infant lung function (ILF). We investigated the degree and tracking of ILF abnormality during the first 2 years of life in CF newborn screened infants.Forced expiratory volume in 0.5 s (FEV0.5), lung clearance index (LCI) and plethysmographic functional residual capacity were measured at ∼3 months, 1 year and 2 years in 62 infants with CF and 34 controls...
November 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29122619/aurora-a-functional-single-nucleotide-polymorphism-snp-correlates-with-clinical-outcome-in-patients-with-advanced-solid-tumors-treated-with-alisertib-an-investigational-aurora-a-kinase-inhibitor
#15
Huifeng Niu, Hyunjin Shin, Feng Gao, Jacob Zhang, Brittany Bahamon, Hadi Danaee, Bohuslav Melichar, Russell J Schilder, Robert L Coleman, Gerald Falchook, Antoine Adenis, Kian Behbakht, Angela DeMichele, Elizabeth Claire Dees, Kimberly Perez, Ursula Matulonis, Piotr Sawrycki, Dirk Huebner, Jeffrey Ecsedy
BACKGROUND: Alisertib (MLN8237) is an investigational, oral, selective Aurora A kinase inhibitor. Aurora A contains two functional single nucleotide polymorphisms (SNPs; codon 31 [F/I] and codon 57 [V/I]) that lead to functional changes. This study investigated the prognostic and predictive significance of these SNPs. METHODS: This study evaluated associations between Aurora A SNPs and overall survival (OS) in The Cancer Genome Atlas (TCGA) database. The Aurora A SNPs were also evaluated as predictive biomarkers for clinical outcomes to alisertib in two phase 2 studies (NCT01045421 and NCT01091428)...
October 16, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29122385/prevalence-and-factors-associated-with-influenza-vaccination-of-persons-over-65-years-old-in-spain-2009-2014
#16
Caridad Dios-Guerra, Juan Manuel Carmona-Torres, Pablo Jesús López-Soto, Ignacio Morales-Cané, María Aurora Rodríguez-Borrego
BACKGROUND: Influenza is a major public health problem. Achieving 65% coverage in people over 65 years old is a health policy priority in Spain. OBJECTIVE: To determine the coverage of influenza vaccination in Spain in 2014 for people over 65 years and to analyze the factors associated with coverage and its progression between 2009 and 2014. METHODS: A descriptive cross-sectional study was conducted that included 18,442 non-institutionalized individuals over 65 years who had participated in the National Health Survey in Spain in 2011 and in the European Health Survey in Spain in 2009 and 2014...
November 6, 2017: Vaccine
https://www.readbyqxmd.com/read/29121248/fusion-of-positron-emission-tomography-computed-tomography-with-magnetic-resonance-imaging-reveals-hamstring-peritendonitis-in-polymyalgia-rheumatica
#17
Claire E Owen, Aurora M T Poon, Sze Ting Lee, Lee Pheng Yap, Richard B Zwar, Christine M McMenamin, Simon K L Lam, David F L Liew, Kunthi Pathmaraj, Andrew Kemp, Andrew M Scott, Russell R C Buchanan
Objectives: To characterize 18F-fluorodeoxyglucose (18F-FDG) uptake on whole-body PET/CT in PMR, and identify its precise anatomic correlate using MRI. Methods: Patients with newly diagnosed PMR according to the 2012 EULAR/ACR classification criteria were prospectively recruited. Participants with GCA were excluded. A whole-body 18F-FDG PET/CT scan was performed in all untreated patients. Qualitative and semiquantitative [standardized uptake value maximum (SUVmax)] scoring of abnormal 18F-FDG uptake was undertaken...
November 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/29120272/factors-associated-with-adherence-to-nutritional-recommendations-before-and-during-pregnancy
#18
Rocío Olmedo-Requena, Julia Gómez-Fernández, Juan Mozas-Moreno, Anne-Mary Lewis-Mikhael, Aurora Bueno-Cavanillas, José-Juan Jiménez-Moleón
Several epidemiologic studies and clinical trials have demonstrated the value of balanced nutrition during pregnancy. This study aimed to examine the degree of adherence to nutritional recommendations among 1,175 pregnant Spanish women and factors associated with such adherence pre-pregnancy and during the first half of pregnancy. Data were collected during June 2004 to March 2007 and included socio-demographic and lifestyle factors. Crude and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were computed using logistic regression models to identify factors associated with adherence to dietary recommendations...
November 9, 2017: Women & Health
https://www.readbyqxmd.com/read/29117710/psychometric-properties-of-the-frost-multidimensional-perfectionism-scale-in-spanish-children-and-adolescents
#19
Aurora Gavino, Raquel Nogueira, Lucía Pérez-Costillas, Antonio Godoy
The Frost Multidimensional Perfectionism Scale (FMPS) is one of the most used instruments to assess perfectionism. The FMPS assesses six dimensions: Concern over Mistakes (CM), Parental Expectations (EP), Parental Criticism (PC), Doubts about Actions (DA), Organization (OR), and Personal Standards (PS). CM, PE, PC, and DA are facets of a more general dimension considered Maladaptive Perfectionism. PS is frequently considered Adaptive Perfectionism. FMPS psychometric properties have been studied in adults but scarcely in children...
November 1, 2017: Assessment
https://www.readbyqxmd.com/read/29115879/design-synthesis-and-biological-activity-of-n-4-phenylsubstituted-7h-pyrrolo-2-3-d-pyrimidin-4-amines-as-dual-inhibitors-of-aurora-kinase-a-and-epidermal-growth-factor-receptor-kinase
#20
Sonali Kurup, Bradley McAllister, Pavlina Liskova, Trusha Mistry, Anthony Fanizza, Dan Stanford, Jolanta Slawska, Ulrich Keller, Alexander Hoellein
Simultaneous inhibition of multiple kinases has been suggested to provide synergistic effects on inhibition of tumour growth and resistance. This study describes the design, synthesis and evaluation of 18 compounds incorporating a pyrrolo[2,3-d]pyrimidine scaffold for dual inhibition of epidermal growth factor receptor kinase (EGFR) and aurora kinase A (AURKA). Compounds 1-18 of this study demonstrate nanomolar inhibition of EGFR and micromolar inhibition of AURKA. Compounds 1-18 allow for a structure-activity relationships (SAR) analysis of the 4-anilino moiety for dual EGFR and AURKA inhibition...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
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