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https://www.readbyqxmd.com/read/27912181/scaling-up-and-ionic-liquid-based-extraction-of-pectinases-from-aspergillus-flavipes-cultures
#1
Vicente E Wolf-Márquez, M Aurora Martínez-Trujillo, Guillermo Aguilar Osorio, Faustino Patiño, María S Álvarez, Ana Rodríguez, M Ángeles Sanromán, Francisco J Deive
The viability of the scaling-up of pectinases production by Aspergillus flavipes at 5L-bioreactor scale has been demonstrated by keeping constant the power input, and a drastic increase in the endo- and exopectinolytic enzyme production was recorded (7- and 40-fold, respectively). The main process variables were modelled by means of logistic and Gompertz equations. In order to overcome the limitations of the conventional downstream strategies, a novel extraction strategy was proposed on the basis of the adequate salting-out potential of two biocompatible cholinium-based ionic liquids (N1112OHCl and N1112OHH2PO4) in aqueous solutions of Tergitol, reaching more than 90% of extraction...
November 18, 2016: Bioresource Technology
https://www.readbyqxmd.com/read/27911109/confocal-microscopy-and-imaging-profilometry-a-new-tool-aimed-to-evaluate-aesthetic-procedures
#2
Gabriella Fabbrocini, Caterina Mazzella, Fabio Montagnaro, Maria Pia De Padova, Sandra Lorenzi, Aurora Tedeschi, Patrizia Forgione, Claudia Capasso, Luigi Sivero, Carla Velotti, Daniela Russo, Rosa Vitiello, Gennaro Ilardi
According to the American Academy of Aesthetic Plastic Surgeons, more than 11 million cosmetic surgical and nonsurgical procedures were performed by board-certified plastic surgeons, dermatologists and otolaryngologists in the United States, totaling more than 12 billion dollars. We performed a retrospective observational multi-centric study on patients treated with a non-animal origin cross-linked hyaluronic acid with different molecular weights for nasolabial folds, evaluating through a new imaging system, profilometric techniques with the confocal microscopy, the durability, the efficacy and the safety of this product...
December 2, 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/27910998/aurora-a-shines-on-t-cell-activation-through-the-regulation-of-lck
#3
Noelia Blas-Rus, Eugenio Bustos-Morán, Noa B Martín-Cófreces, Francisco Sánchez-Madrid
Different protein kinases control signaling emanating from the T cell receptor (TCR) during antigen-specific T cell activation. Mitotic kinases, e.g. Aurora-A, have been widely studied in the context of mitosis due to their role during microtubule (MT) nucleation, becoming critical regulators of cell cycle progression. We have recently described a specific role for Aurora-A kinase in antigenic T cell activation. Blockade of Aurora-A in T cells severely disrupts the dynamics of MTs and CD3ζ-bearing signaling vesicles during T cell activation...
December 2, 2016: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/27910097/chronic-migraine-an-update-on-physiology-imaging-and-the-mechanism-of-action-of-two-available-pharmacologic-therapies
#4
Sheena K Aurora, Mitchell F Brin
Several lines of research support the hypothesis that migraine is a spectrum of illness, with clinical symptoms that vary along a continuum from episodic migraine to chronic migraine. Physiologic changes may result in episodic migraine evolving into chronic migraine over months to years in susceptible individuals. With chronification, headache frequency increases, becoming more disabling and less responsive to therapy. Neurophysiologic and functional imaging research has reported that chronic migraine may be associated with severity-specific metabolic, functional, and structural abnormalities in the brainstem...
December 2, 2016: Headache
https://www.readbyqxmd.com/read/27909956/docking-and-three-dimensional-quantitative-structure-activity-relationship-analyses-of-imidazole-and-thiazolidine-derivatives-as-aurora-a-kinase-inhibitors
#5
Chaeuk Im
Aurora A kinase is involved in the inactivation of apoptosis leading to ovarian, breast, colon, and pancreatic cancers. Inhibitors of Aurora A kinase promote aberrant mitosis resulting in arrest at a pseudo G1 state to induce mitotic catastrophe, ultimately leading to apoptosis. In this study, ligand-based and docking-based three-dimensional quantitative structure-activity relationship (3D-QSAR) analyses of imidazole and thiazolidine derivatives as potential Aurora A kinase inhibitors were performed. The results provided highly reliable and predictive 3D-QSAR comparative molecular similarity index analysis (CoMSIA) models with a cross-validated q(2) value of 0...
December 1, 2016: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/27905678/a-phase-i-ii-trial-of-at9283-a-selective-inhibitor-of-aurora-kinase-in-children-with-relapsed-or-refractory-acute-leukemia-challenges-to-run-early-phase-clinical-trials-for-children-with-leukemia
#6
B Vormoor, G J Veal, M J Griffin, A V Boddy, J Irving, L Minto, M Case, U Banerji, K E Swales, J R Tall, A S Moore, M Toguchi, G Acton, K Dyer, C Schwab, C J Harrison, J D Grainger, D Lancaster, P Kearns, D Hargrave, J Vormoor
Aurora kinases regulate mitosis and are commonly overexpressed in leukemia. This phase I/IIa study of AT9283, a multikinase inhibitor, was designed to identify maximal tolerated doses, safety, pharmacokinetics, and pharmacodynamic activity in children with relapsed/refractory acute leukemia. The trial suffered from poor recruitment and terminated early, therefore failing to identify its primary endpoints. AT9283 caused tolerable toxicity, but failed to show clinical responses. Future trials should be based on robust preclinical data that provide an indication of which patients may benefit from the experimental agent, and recruitment should be improved through international collaborations and early combination with established treatment strategies...
December 1, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27902367/staphylococcal-cassette-chromosome-mec-typing-and-meca-sequencing-in-methicillin-resistant-staphylococci-from-algeria-a-highly-diversified-element-with-new-mutations-in-meca
#7
Ferhat Djoudi, Celestino Bonura, Abdelaziz Touati, Aurora Aléo, Said Benallaoua, Caterina Mammina
Genetic mechanisms of methicillin resistance are still relevant in staphylococci. The aims of this study are to assess the possible exchanges of staphylococcal cassette chromosome mec (SCCmec) among isolates of methicillin-resistant staphylococci (MRS) and to check for known or new mutations in mecA DNA. A total of 35 MRS non-repetitive isolates were recovered, including 20 Staphylococcushaemolyticus, 7 Staphylococcusaureus, 4 Staphylococcussciuri, 2 Staphylococcussaprophyticus and 1 isolate each of Staphylococcusxylosus and Staphylococcuslentus...
November 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27901353/can-new-chemical-therapies-improve-the-management-of-multiple-sclerosis-in-children
#8
Emanuele D'Amico, Aurora Zanghì, Francesco Patti
Pediatric multiple sclerosis (MS) may represent up to 10% of all MS cases. Establishing the diagnosis of MS in a child is complicated by the limited diagnostic criteria and the possibility of significant overlap with acute disseminated encephalomyelitis. Areas covered: This review puts in perspective the potential possibilities given by new pharmacological agents in pediatric MS; focusing on the unmet needs in terms of research development in this field. Expert Opinion: The treatment landscape of MS has dramatically changed in the last 5 years...
November 30, 2016: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/27901153/structure-activity-relationship-for-the-solid-state-emission-of-a-new-family-of-push-pull-%C3%AF-extended-chromophores
#9
Andrea Nitti, Francesca Villafiorita-Monteleone, Aurora Pacini, Chiara Botta, Tersilla Virgili, Alessandra Forni, Elena Cariati, Massimo Boiocchi, Dario Pasini
We report the design, synthesis, molecular optical properties, and solid state emissive behaviour of a series of novel compounds, which, similar to the archetypal AIE luminogen tetraphenylethene, are formed of a central olefin stator and decorated with either three or four rotors. These rotors, being either electron-rich substituted benzenes, or electron-withdrawing functional groups (esters, ketones, cyano groups) confer a "push-pull" character to the overall molecular structure. Building on both new and already published contributions, a comprehensive picture of the properties and the potential of these compounds is provided...
November 30, 2016: Faraday Discussions
https://www.readbyqxmd.com/read/27898709/individual-differences-in-emotion-regulation-childhood-trauma-and-proneness-to-shame-and-guilt-in-adolescence
#10
Aurora Szentágotai-Tătar, Andrei C Miu
Dispositional shame and guilt have been associated with psychopathology and an increasing number of studies have traced this relation back to adolescence. This developmental period is thought to be characterized by maturational changes in emotion regulation, which also play an important role in vulnerability to psychopathology, but little is known about the links between emotion regulation and dispositional shame and guilt. The current study investigated the relations between individual differences in the habitual use of a wide range of emotion regulation strategies and proneness to shame and guilt in a large sample of adolescents (N = 706), aged 13 to 17 years...
2016: PloS One
https://www.readbyqxmd.com/read/27895801/in-vitro-evaluation-of-a-combination-treatment-involving-anticancer-agents-and-an-aurora-kinase-b-inhibitor
#11
Senna Sakai, Hiroto Izumi, Yukiko Yoshiura, Yoshifumi Nakayama, Takahiro Yamaguchi, Yoshikazu Harada, Chiho Koi, Hiroyuki Kurata, Yasuo Morimoto
Aurora kinase B (AURKB) inhibitors are regarded as potential molecular-targeting drugs for cancer therapy. The present study evaluated the cytotoxic effect of a combination of AZD1152-hQPA, an AURKB inhibitor, and various anticancer agents on the HeLa human cervical cancer cell line, as well as its cisplatin-resistant equivalent HCP4 cell line. It was demonstrated that AZD1152-hQPA had an antagonistic effect on the cytotoxicity of cisplatin, etoposide and doxorubicin, but had a synergistic effect on that of all-trans-retinoic acid (ATRA), Am80 and TAC-101, when tested on HeLa cells...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27894319/erratum-to-detection-of-atm-germline-variants-by-the-p53-mitotic-centrosomal-localization-test-in-brca1-2-negative-patients-with-early-onset-breast-cancer
#12
Andrea Prodosmo, Amelia Buffone, Manlio Mattioni, Agnese Barnabei, Agnese Persichetti, Aurora De Leo, Marialuisa Appetecchia, Arianna Nicolussi, Anna Coppa, Salvatore Sciacchitano, Carolina Giordano, Paola Pinnarò, Giuseppe Sanguineti, Lidia Strigari, Gabriele Alessandrini, Francesco Facciolo, Maurizio Cosimelli, Gian Luca Grazi, Giacomo Corrado, Enrico Vizza, Giuseppe Giannini, Silvia Soddu
No abstract text is available yet for this article.
November 28, 2016: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/27893412/molecular-mechanism-and-therapeutic-implications-of-selinexor-kpt-330-in-liposarcoma
#13
Manoj Garg, Deepika Kanojia, Anand Mayakonda, Jonathan W Said, Ngan B Doan, Wenwen Chien, Trivadi S Ganesan, Linda Shyue Huey Chuang, Nachiyappan Venkatachalam, Erkan Baloglu, Sharon Shacham, Michael Kauffman, H Phillip Koeffler
Exportin-1 mediates nuclear export of multiple tumor suppressor and growth regulatory proteins. Aberrant expression of exportin-1 is noted in human malignancies, resulting in cytoplasmic mislocalization of its target proteins. We investigated the efficacy of selinexor against liposarcoma cells both in vitro and in vivo. Exportin-1 was highly expressed in liposarcoma samples and cell lines as determined by immunohistochemistry, western blot, and immunofluorescence assay. Knockdown of endogenous exportin-1 inhibited proliferation of liposarcoma cells...
November 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27887633/antitumor-activity-of-ty-011-against-gastric-cancer-by-inhibiting-aurora-a-aurora-b-and-vegfr2-kinases
#14
Wang Liu, Yu Lu, Xiaoping Chai, Xiao Liu, Tong Zhu, Xihan Wu, Yanfen Fang, Xuan Liu, Xiongwen Zhang
BACKGROUND: Overexpression of Aurora A and B has been reported in a wide range of tumor types, including gastric cancer. Anti-angiogenesis has been considered as an important therapeutic modality in advanced gastric cancer. Here we identified a novel compound TY-011 with promising antitumor activity by targeting mitotic kinases (Aurora A and B) and angiogenic receptor tyrosine kinase (VEGFR2). METHODS: HTRF® KinEASE™ assay was used to detect the effect of TY-011 against Aurora A, Aurora B and VEGFR2 activities...
November 25, 2016: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/27884697/3-cyano-6-5-methyl-3-pyrazoloamino-pyridines-part-2-a-dual-inhibitor-of-aurora-kinase-and-tubulin-polymerization
#15
Masahiko Morioka
A new class of a dual inhibitor of Aurora kinase and tubulin polymerization was created by introducing various substituted phenoxyethylamino or pyridyloxyethylamino groups to the 2-position of 3-cyano-4-methyl-6-(5-methyl-3-pyrazoloamino)-pyridine. Compound 3g exhibited Aurora kinase inhibition, excellent protein kinase selectivity to Aurora kinase in comparison with 66 other kinases, inhibition of phosphorylation of Ser10 of histone H3 as an Aurora kinase inhibitor, inhibition of tubulin polymerization in vitro, good cell membrane permeability, and a good PK profile...
December 15, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27881301/structure-of-the-mis12-complex-and-molecular-basis-of-its-interaction-with-cenp-c-at-human-kinetochores
#16
Arsen Petrovic, Jenny Keller, Yahui Liu, Katharina Overlack, Juliane John, Yoana N Dimitrova, Simon Jenni, Suzan van Gerwen, Patricia Stege, Sabine Wohlgemuth, Pascaline Rombaut, Franz Herzog, Stephen C Harrison, Ingrid R Vetter, Andrea Musacchio
Kinetochores, multisubunit protein assemblies, connect chromosomes to spindle microtubules to promote chromosome segregation. The 10-subunit KMN assembly (comprising KNL1, MIS12, and NDC80 complexes, designated KNL1C, MIS12C, and NDC80C) binds microtubules and regulates mitotic checkpoint function through NDC80C and KNL1C, respectively. MIS12C, on the other hand, connects the KMN to the chromosome-proximal domain of the kinetochore through a direct interaction with CENP-C. The structural basis for this crucial bridging function of MIS12C is unknown...
November 3, 2016: Cell
https://www.readbyqxmd.com/read/27881300/structure-of-the-mind-complex-defines-a-regulatory-focus-for-yeast-kinetochore-assembly
#17
Yoana N Dimitrova, Simon Jenni, Roberto Valverde, Yadana Khin, Stephen C Harrison
Kinetochores connect centromeric nucleosomes with mitotic-spindle microtubules through conserved, cross-interacting protein subassemblies. In budding yeast, the heterotetrameric MIND complex (Mtw1, Nnf1, Nsl1, Dsn1), ortholog of the metazoan Mis12 complex, joins the centromere-proximal components, Mif2 and COMA, with the principal microtubule-binding component, the Ndc80 complex (Ndc80C). We report the crystal structure of Kluyveromyces lactis MIND and examine its partner interactions, to understand the connection from a centromeric nucleosome to a much larger microtubule...
November 3, 2016: Cell
https://www.readbyqxmd.com/read/27881045/exploring-unobserved-heterogeneity-in-perinatal-and-neonatal-mortality-risks-the-case-of-an-italian-sharecropping-community-1900-39
#18
Francesco Scalone, Patrizia Agati, Aurora Angeli, Annalisa Donno
Previous researchers have found that traditional determinants explain only a limited part of the variation in perinatal and infant mortality at the family level. In the study reported in this paper, we explored the factors that make the perinatal/neonatal death risk more heterogeneous across families. We estimated logistic regressions with cluster random effects at the maternal level, using data from the Italian village of Granarolo from 1900 to 1939. We estimated the effects of selected predictors on perinatal/neonatal mortality and unexplained inter-family variation...
November 24, 2016: Population Studies
https://www.readbyqxmd.com/read/27879390/phosphorylation-of-map65-1-by-arabidopsis-aurora-kinases-is-required-for-efficient-cell-cycle-progression
#19
Joanna Boruc, Annika Weimer, Virginie Stoppin-Mellet, Evelien Mylle, Ken Kosetsu, Cesyen Cedeno, Michel Jaquinod, Maria Njo, Liesbeth De Milde, Peter Tompa, Nathalie Gonzalez, Dirk Inze, Tom Beeckman, Marylin Vantard, Daniel van Damme
Aurora kinases are key effectors of mitosis. Plant Auroras are functionally divided into two clades. The α Auroras (Aurora1 and Aurora2) associate with the spindle and the cell plate and are implicated in controlling formative divisions throughout plant development. The β Aurora (Aurora3) localizes to centromeres and likely functions in chromosome separation. In contrast to the wealth of data available on the role of Aurora in other kingdoms, knowledge on their function in plants is merely emerging. This is exemplified by the fact that only histone H3 and the plant homologue of TPX2 have been identified as Aurora substrates in plants...
November 22, 2016: Plant Physiology
https://www.readbyqxmd.com/read/27875605/sustaining-family-physicians-in-urban-underserved-settings
#20
Anne Getzin, Bonnie L Bobot, Deborah Simpson
OBJECTIVE: Our objective was to identify factors that sustain family physicians practicing in Milwaukee's underserved urban areas. METHODS: Family physicians with clinical careers in Milwaukee's urban, underserved communities were identified and invited to participate in a 45-60 minute interview using a literature-based semi-structured protocol. Each interview was transcribed and de-identified prior to independent analysis using a grounded theory qualitative approach by two authors to yield sustaining themes...
November 2016: Family Medicine
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