keyword
https://read.qxmd.com/read/38546430/production-of-lipopeptides-from-bacillus-velezensis-bvq121-and-their-application-in-chitosan-antibacterial-coating
#1
JOURNAL ARTICLE
Rong Qian, Xinyu Ji, Xiaoqi Xu, Sha Li, Hong Xu
The extracellular substance of Bacillus has antibacterial effects inhibiting multiple foodborne pathogens and plays important roles in food production. This study found one Bacillus velezensis BVQ121 strain producing antibacterial lipopeptides (BVAL). After optimization of the fermentation conditions, the BVAL yield was the highest at 1.316 ± 0.03 g/L in reality with the initial pH 6.0, temperature 31 °C, and shaker speed 238 rpm when the optimal nitrogen and carbon sources were used in Landy medium for fermentation...
March 28, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38539197/regulation-mechanism-and-bioactivity-characteristic-of-surfactin-homologues-with-c14-and-c15-fatty-acid-chains
#2
JOURNAL ARTICLE
Yumeng Su, Ling Gao, Chenyu Li, Liang Wang, Huimin Zhou, Chenhao Zhang, Xiaole Xia
BACKGROUND: Surfactin, a green lipopeptide bio-surfactant, exhibits excellent surface, hemolytic, antibacterial, and emulsifying activities. However, a lack of clear understanding of the synthesis regulation mechanism of surfactin homologue components has hindered the customized production of surfactin products with different biological activities. RESULTS: In this study, exogenous valine and 2-methylbutyric acid supplementation significantly facilitated the production of C14-C15 surfactin proportions (up to 75% or more), with a positive correlation between the homologue proportion and fortified concentration...
March 27, 2024: Microbial Cell Factories
https://read.qxmd.com/read/38537511/a-novel-antimicrobial-peptide-with-broad-spectrum-and-exceptional-stability-derived-from-the-natural-peptide-brevicidine
#3
JOURNAL ARTICLE
Ping Yang, Wenbo Mao, Jingying Zhang, Yinyin Yang, Fangyan Zhang, Xu Ouyang, Beibei Li, Xiaoyan Wu, Zufang Ba, Kaixin Ran, Yali Tian, Hui Liu, Yun Zhang, Sanhu Gou, Chao Zhong, Jingman Ni
The global issue of antibiotic resistance is increasingly severe, highlighting the urgent necessity for the development of new antibiotics. Brevicidine, a natural cyclic lipopeptide, exhibits remarkable antimicrobial activity against Gram-negative bacteria. In this study, a comprehensive structure-activity relationship of Brevicidine was investigated through 20 newly synthesized cyclic lipopeptide analogs, resulting in the identification of an optimal linear analog 22. The sequence of analog 22 consisted of five d-amino acids and four non-natural amino acid 2,5-diaminovaleric acid (Orn) and conjugated with decanoic acid at N-terminal...
March 15, 2024: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/38535181/exploring-mechanisms-of-antifungal-lipopeptide-iturin-a-from-bacillus-against-aspergillus-niger
#4
JOURNAL ARTICLE
Shiyi Wang, Min Xu, Ye Han, Zhijiang Zhou
The control of Aspergillus niger ( A. niger ) is of great significance for the agricultural economy and food safety. In this study, the antifungal effect and mechanism of iturin A from Bacillus amyloliquefaciens (CGMCC No. 8473) against A. niger (ATCC 16404) were investigated using biochemical analyses and proteomics. Changes in a mycelium treated with iturin A were observed using scanning electron microscopy and transmission electron microscopy, including mycelial twisting and collapse, organelle disintegration, and intracellular vacuolization...
February 24, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38534689/daptomycin-use-for-persistent-coagulase-negative-staphylococcal-bacteremia-in-a-neonatal-intensive-care-unit
#5
JOURNAL ARTICLE
Eleni Papachatzi, Despoina Gkentzi, Sotiris Tzifas, Theodore Dassios, Gabriel Dimitriou
During the last two decades, the incidence of late-onset sepsis (LOS) has increased due to improved survival of premature neonates. Persistent bacteremia (PB) in LOS is defined as more than two positive blood cultures obtained on different calendar days during the same infectious episode. Although rare, PB should be treated aggressively to prevent adverse outcomes. Daptomycin, a lipopeptide antibiotic, has been used in neonates with persistent coagulase-negative staphylococci (CoNS) bacteremia with promising results, but studies reporting on the efficacy and safety of the agent are scarce...
March 12, 2024: Antibiotics
https://read.qxmd.com/read/38529919/lipopeptide-c-17-fengycin-b-exhibits-a-novel-antifungal-mechanism-by-triggering-metacaspase-dependent-apoptosis-in-fusarium-oxysporum
#6
JOURNAL ARTICLE
Ying-Jie Deng, Zheng Chen, Yan-Ping Chen, Jie-Ping Wang, Rong-Feng Xiao, Xun Wang, Bo Liu, Mei-Chun Chen, Jin He
Fusarium wilt is a worldwide soil-borne fungal disease caused by Fusarium oxysporum that causes serious damage to agricultural products. Therefore, preventing and treating fusarium wilt is of great significance. In this study, we purified ten single lipopeptide fengycin components from Bacillus subtilis FAJT-4 and found that C17 fengycin B inhibited the growth of F. oxysporum FJAT-31362. We observed early apoptosis hallmarks, including reactive oxygen species accumulation, mitochondrial dysfunction, and phosphatidylserine externalization in C17 fengycin B-treated F...
March 26, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38528101/non-modular-fatty-acid-synthases-yield-distinct-n-terminal-acylation-in-ribosomal-peptides
#7
JOURNAL ARTICLE
Hengqian Ren, Chunshuai Huang, Yuwei Pan, Shravan R Dommaraju, Haiyang Cui, Maolin Li, Mayuresh G Gadgil, Douglas A Mitchell, Huimin Zhao
Recent efforts in genome mining of ribosomally synthesized and post-translationally modified peptides (RiPPs) have expanded the diversity of post-translational modification chemistries. However, RiPPs are rarely reported as hybrid molecules incorporating biosynthetic machinery from other natural product families. Here we report lipoavitides, a class of RiPP/fatty-acid hybrid lipopeptides that display a unique, putatively membrane-targeting 4-hydroxy-2,4-dimethylpentanoyl (HMP)-modified N terminus. The HMP is formed via condensation of isobutyryl-coenzyme A (isobutyryl-CoA) and methylmalonyl-CoA catalysed by a 3-ketoacyl-(acyl carrier protein) synthase III enzyme, followed by successive tailoring reactions in the fatty acid biosynthetic pathway...
March 25, 2024: Nature Chemistry
https://read.qxmd.com/read/38527936/a-lipopeptidomimetic-of-transcriptional-activation-domains-selectively-disrupts-med25-protein-protein-interactions
#8
JOURNAL ARTICLE
Olivia N Pattelli, Estefanía Martínez Valdivia, Matthew S Beyersdorf, Clint S Regan, Mónica Rivas, Katherine A Hebert, Sofia D Merajver, Tomasz Cierpicki, Anna K Mapp
Short amphipathic peptides are capable of binding to transcriptional coactivators, often targeting the same binding surfaces as native transcriptional activation domains. However, they do so with modest affinity and generally poor selectivity, limiting their utility as synthetic modulators. Here we show that incorporation of a medium-chain, branched fatty acid to the N-terminus of one such heptameric lipopeptidomimetic (LPPM-8) increases the affinity for the coactivator Med25 >20-fold (Ki >100 μM to 4 μM), rendering it an effective inhibitor of Med25 protein-protein interactions (PPIs)...
March 25, 2024: Angewandte Chemie
https://read.qxmd.com/read/38527516/lipopeptide-biosurfactant-as-a-potential-root-canal-irrigation-agent-antimicrobial-and-anti-biofilm-evaluation
#9
JOURNAL ARTICLE
Isty Adhitya Purwasena, Dinda Kurnia Fitri, Destaya Mentari Putri, Hartanto Endro, Myrna Nurlatifah Zakaria
OBJECTIVES: Lipopeptide Biosurfactant (LB) is bacteria derived compound able to reduce surface tension between water and hydrophobic substances and exhibit antimicrobial and anti-biofilm properties. This study aimed to investigate the antimicrobial and anti-biofilm effect of a Lipopeptide Biosurfactant (LB) on Enterococcus faecalis, and its potential use in root canal treatment, either as a standalone irrigation solution or in conjunction with sodium hypochlorite (NaOCl). METHODS: LB was extracted from Bacillus clausii isolate and the dry extract was diluted in deionized water...
March 23, 2024: Journal of Dentistry
https://read.qxmd.com/read/38524560/effects-of-a-novel-bacillus-subtilis-gxyx-crude-lipopeptide-against-salmonella-enterica-serovar-typhimurium-infection-in-mice
#10
JOURNAL ARTICLE
Jingya Zhang, Yifan Wu, Wei Li, Honglin Xie, Jingyan Li, Yongqiang Miao, Zengqi Yang, Yefei Zhou, Xinglong Wang
The increased rate of antibiotic resistance strongly limits the resolution of Salmonella enterica serovar Typhimurium (S. Typhimurium) infection. Therefore, new strategies to control bacterial infections are urgently needed. Bacillus subtilis (B. subtilis) and its metabolites are desirable antibacterial agents. Here, we aimed to evaluate the antibacterial activity of the novel B. subtilis strain GXYX (No: PRJNA940956) crude lipopeptide against S . Typhimurium. In vitro, GXYX crude lipopeptides affected S . Typhimurium biofilm formation and swimming and attenuated the adhesion and invasion abilities of S ...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38516010/identification-and-genomic-characterization-of-pseudomonas-spp-displaying-biocontrol-activity-against-sclerotinia-sclerotiorum-in-lettuce
#11
JOURNAL ARTICLE
Daphné Albert, Antoine Zboralski, Marie Ciotola, Mélanie Cadieux, Adrien Biessy, Jochen Blom, Carole Beaulieu, Martin Filion
Lettuce is an economically major leafy vegetable that is affected by numerous diseases. One of the most devastating diseases of lettuce is white mold caused by Sclerotinia sclerotiorum . Control methods for this fungus are limited due to the development of genetic resistance to commonly used fungicides, the large number of hosts and the long-term survival of sclerotia in soil. To elaborate a new and more sustainable approach to contain this pathogen, 1,210 Pseudomonas strains previously isolated from agricultural soils in Canada were screened for their antagonistic activity against S...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38511621/biosynthesis-of-a-new-skyllamycin-in-streptomyces-nodosus-a-cytochrome-p450-forms-an-epoxide-in-the-cinnamoyl-chain
#12
JOURNAL ARTICLE
Yuhao Song, Jose A Amaya, Vidhi C Murarka, Hugo Mendez, Mark Hogan, Jimmy Muldoon, Paul Evans, Yannick Ortin, Steven L Kelly, David C Lamb, Thomas L Poulos, Patrick Caffrey
Activation of a silent gene cluster in Streptomyces nodosus leads to synthesis of a cinnamoyl-containing non-ribosomal peptide (CCNP) that is related to skyllamycins. This novel CCNP was isolated and its structure was interrogated using mass spectrometry and nuclear magnetic resonance spectroscopy. The isolated compound is an oxidised skyllamycin A in which an additional oxygen atom is incorporated in the cinnamoyl side-chain in the form of an epoxide. The gene for the epoxide-forming cytochrome P450 was identified by targeted disruption...
March 21, 2024: Organic & Biomolecular Chemistry
https://read.qxmd.com/read/38508087/a-molecular-overview-of-the-polymyxin-lps-interaction-in-the-context-of-its-mode-of-action-and-resistance-development
#13
REVIEW
Indira Padhy, Sambit K Dwibedy, Saswat S Mohapatra
With the rising incidences of antimicrobial resistance (AMR) and the diminishing options of novel antimicrobial agents, it is paramount to decipher the molecular mechanisms of action and the emergence of resistance to the existing drugs. Polymyxin, a cationic antimicrobial lipopeptide, is used to treat infections by Gram-negative bacterial pathogens as a last option. Though polymyxins were identified almost seventy years back, their use has been restricted owing to toxicity issues in humans. However, their clinical use has been increasing in recent times resulting in the rise of polymyxin resistance...
March 12, 2024: Microbiological Research
https://read.qxmd.com/read/38501807/a-machine-learning-approach-to-predict-daptomycin-exposure-from-two-concentrations-based-on-monte-carlo-simulations
#14
JOURNAL ARTICLE
Cyrielle Codde, Florence Rivals, Alexandre Destere, Yeleen Fromage, Marc Labriffe, Pierre Marquet, Clément Benoist, Laure Ponthier, Jean-François Faucher, Jean-Baptiste Woillard
Daptomycin is a concentration-dependent lipopeptide antibiotic for which exposure/effect relationships have been shown. Machine learning (ML) algorithms, developed to predict the individual exposure to drugs, have shown very good performances in comparison to maximum a posteriori Bayesian estimation (MAP-BE). The aim of this work was to predict the area under the blood concentration curve (AUC) of daptomycin from two samples and a few covariates using XGBoost ML algorithm trained on Monte Carlo simulations...
March 19, 2024: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/38500587/-bacillus-velezensis-lt1-a-potential-biocontrol-agent-for-southern-blight-on-coptis-chinensis
#15
JOURNAL ARTICLE
Tao Tang, Fanfan Wang, Houyun Huang, Jie Guo, Xiaoliang Guo, Yuanyuan Duan, Xiaoyue Wang, Qingfang Wang, Jingmao You
INTRODUCTION: Southern blight, caused by Sclerotium rolfsii , poses a serious threat to the cultivation of Coptis chinensis , a plant with significant medicinal value. The overreliance on fungicides for controlling this pathogen has led to environmental concerns and resistance issues. There is an urgent need for alternative, sustainable disease management strategies. METHODS: In this study, Bacillus velezensis LT1 was isolated from the rhizosphere soil of diseased C...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38500040/comprehensive-genomic-analysis-of-bacillus-subtilis-and-bacillus-paralicheniformis-associated-with-the-pearl-millet-panicle-reveals-their-antimicrobial-potential-against-important-plant-pathogens
#16
JOURNAL ARTICLE
Mushineni Ashajyothi, Shivannegowda Mahadevakumar, Y N Venkatesh, Pullabhotla V S R N Sarma, Chalasani Danteswari, Alexander Balamurugan, Ganesan Prakash, Vikas Khandelwal, C Tarasatyavathi, Appa Rao Podile, Mysore S Kirankumar, Siddaiah Chandranayaka
BACKGROUND: Plant microbiome confers versatile functional roles to enhance survival fitness as well as productivity. In the present study two pearl millet panicle microbiome member species Bacillus subtilis PBs 12 and Bacillus paralicheniformis PBl 36 found to have beneficial traits including plant growth promotion and broad-spectrum antifungal activity towards taxonomically diverse plant pathogens. Understanding the genomes will assist in devising a bioformulation for crop protection while exploiting their beneficial functional roles...
March 18, 2024: BMC Plant Biology
https://read.qxmd.com/read/38495510/distinct-microbiota-assembly-and-functional-patterns-in-disease-resistant-and-susceptible-varieties-of-tobacco
#17
JOURNAL ARTICLE
Luhua Yang, Yuan Guo, Hui Yang, Shun Li, Yunzeng Zhang, Cheng Gao, Tian Wei, Likai Hao
The plant microbiota is believed to be an accessory genome that extends plant functions, forming holobionts together with the host plant. Plant disease resistance, therefore, is inextricably linked with plant microbiota, which play important roles in plant growth and health. To explore the relationship between plant microbiota and disease resistance, we investigated the tobacco microbiome of two varieties with contrasting disease-resistance levels to bacterial wilt and black shank diseases. Comparative microbiome analysis indicated that the resistant variety assembled a distinct microbiota with higher network complexity and diversity...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38491989/new-antibacterial-peptaibiotics-against-plant-and-fish-pathogens-from-the-deep-sea-derived-fungus-simplicillium-obclavatum-eiodsf-020
#18
JOURNAL ARTICLE
Xiao Liang, Jia-Fan Yang, Zhong-Hui Huang, Xuan Ma, Yan Yan, Shu-Hua Qi
Bacterial diseases could severely harm agricultural production. To develop new antibacterial agents, the secondary metabolites of a deep-sea-derived fungus Simplicillium obclavatum EIODSF 020 with antibacterial activities against plant and fish pathogens were investigated by a bioassay-guided approach, which led to the isolation of 11 new peptaibiotics, simplicpeptaibs A-K ( 1 - 11 ). They contain 16-19 residues, including β-alanine, tyrosine, or tyrosine O -sulfate, that were rarely present in peptaibiotics...
March 16, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38490458/enhanced-control-efficacy-of-bacillus-subtilis-nm4-via-integration-of-chlorothalonil-on-potato-early-blight-caused-by-alternaria-solani
#19
JOURNAL ARTICLE
Jun Su Noh, Seo Hyun Hwang, Chaw Ei Htwe Maung, Jeong-Yong Cho, Kil Yong Kim
Early blight caused by Alternaria solani is a common foliar disease of potato around the world, and serious infections result in reduced yields and marketability due to infected tubers. The major aim of this study is to figure out the synergistic effect between microorganism and fungicides and to evaluate the effectiveness of Bacillus subtilis NM4 in the control of early blight in potato. Based on its colonial morphology and a 16S rRNA analysis, a bacterial antagonist isolated from kimchi was identified as B...
March 13, 2024: Microbial Pathogenesis
https://read.qxmd.com/read/38489053/microbial-lipopeptides-their-pharmaceutical-and-biotechnological-potential-applications-and-way-forward
#20
REVIEW
K P Sreelakshmi, M Madhuri, R Swetha, Vivek Rangarajan, Utpal Roy
As lead molecules, cyclic lipopeptides with antibacterial, antifungal, and antiviral properties have garnered a lot of attention in recent years. Because of their potential, cyclic lipopeptides have earned recognition as a significant class of antimicrobial compounds with applications in pharmacology and biotechnology. These lipopeptides, often with biosurfactant properties, are amphiphilic, consisting of a hydrophilic moiety, like a carboxyl group, peptide backbone, or carbohydrates, and a hydrophobic moiety, mostly a fatty acid...
March 15, 2024: World Journal of Microbiology & Biotechnology
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