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https://www.readbyqxmd.com/read/27832784/antitussive-anti-pyretic-and-toxicological-evaluation-of-ma-xing-gan-shi-tang-in-rodents
#1
Yu-Chin Lin, Ching-Wen Chang, Chi-Rei Wu
BACKGROUND: Ma-Xing-Gan-Shi-Tang (abbreviated as MXGST), an important Chinese herbal prescribed for cough, bronchial inflammation and fever from pneumonia, consists of four medicinal herbs, including Ephedrae herb, Semen Pruni Armeniacae, licorice and Gypsum. These components, especially Ephedrae and Semen Pruni Armeniacae, possess antitussive activities, but they have severe adverse effects. METHODS: The pharmacological activities of MXGST extract in clinical use were investigated with citric acid-induced cough, acetylcholine/histamine-induced bronchial contraction and lipopolysaccharide (LPS)-induced fever in rodents...
November 10, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27783077/apricot-and-other-seed-stones-amygdalin-content-and-the-potential-to-obtain-antioxidant-angiotensin-i-converting-enzyme-inhibitor-and-hypocholesterolemic-peptides
#2
M C García, E González-García, R Vásquez-Villanueva, M L Marina
Stones from olives and Prunus genus fruits are cheap and sustainable sources of proteins and could be potential sources of bioactive peptides. The main limitation to the use of these seeds is the presence of amygdalin. This work proposes to determine amygdalin in olive and Prunus seeds and in protein isolates obtained from them. Moreover, antioxidant, angiotensin I converting enzyme (ACE) inhibitor, and hypocholesterolemic properties will be evaluated in hydrolysates obtained from these seeds. Despite some seeds contained amygdalin, all protein isolates were free of this substance...
October 26, 2016: Food & Function
https://www.readbyqxmd.com/read/27527657/integrated-identification-qualification-and-quantification-strategy-for-pharmacokinetic-profile-study-of-guizhi-fuling-capsule-in-healthy-volunteers
#3
Yun-Xi Zhong, Xiao-Liang Jin, Shi-Yin Gu, Ying Peng, Ke-Rong Zhang, Bing-Chen Ou-Yang, Yu Wang, Wei Xiao, Zhen-Zhong Wang, Ji-Ye Aa, Guang-Ji Wang, Jian-Guo Sun
Guizhi Fuling capsule (GZFL), a traditional Chinese medicine formulation, is widely used in China to relieve pain from dysmenorrhea and is now in a Phase II clinical trial in the USA. Due to the low exposure of the five main medicative ingredients (amygdalin, cinnamic acid, gallic acid, paeoniflorin and paeonol) of GZFL in human, a strategy was built to qualitatively and quantitatively identify the possible metabolites of GZFL and to describe the pharmacokinetic profiles of GZFL in human. In this strategy, LC-Q-TOF/MS was used to identify and structurally elucidate the possible metabolites of GZFL in vivo; and a time-based metabolite-confirming step (TBMCs) was used to confirm uncertain metabolites...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27514823/pharmacokinetic-effects-of-cinnamic-acid-amygdalin-glycyrrhizic-acid-and-liquiritin-on-ephedra-alkaloids-in-rats
#4
Yinghong Tang, Mengkai Zheng, Yu-Lin Chen, Jianzhen Chen, Yu He
BACKGROUND AND OBJECTIVES: Ephedra alkaloids, including ephedrine (EP), pseudoephedrine (PEP) and methylephedrine (MEP), are sympathomimetic compounds with known toxicities but many Ephedra (Ephedrae herba) preparations, such as Ephedra decoction, have been clinically applied for centuries. In order to explore the possible detoxification mechanism of Ephedra alkaloids, four representative compounds in Ephedra decoction (cinnamic acid, amygdalin, glycyrrhizic acid and liquiritin) were studied for their pharmacokinetic effects on Ephedra alkaloids in Sprague-Dawley rats...
August 11, 2016: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/27400480/correlation-between-the-transdermal-characteristics-of-pseudoephedrine-and-amygdalin-in-majiepingchuan-in-vitro
#5
COMPARATIVE STUDY
Hui Kong, Huihua Qu, Baoping Qu, Wenhao Zeng, Yan Zhao, Xueqian Wang, Qingguo Wang
OBJECTIVE: To analyze the transdermal profile of pseudoephedrine and amygdalin in the Traditional Chinese Medicine majiepingchuan in rat skin and to reveal their interaction. METHODS: A Franz diffusion cell was used in vitro to evaluate the transdermal parameters of cumulative transdermal flux (Q(tot)), cumulative transmission (T(tot)), and mean penetration rate (Kp) of pseudoephedrine and amygdalin in majiepingchuan. Linear regression analyses of Q(tot) over time of pseudoephedrine vs amygdalin and their ratios was adopted for correlation evaluation...
April 2016: Journal of Traditional Chinese Medicine, Chung i Tsa Chih Ying Wen Pan
https://www.readbyqxmd.com/read/27356394/-preparation-technology-of-huayu-xiaozhong-spray-films
#6
Yu-lian Zhu, Hua Huang, Ding Xia, Yuan-zhi Ren
OBJECTIVE: The extraction process and film-forming preparation technology of Huayu Xiaozhong spray film was optimized respectively by orthogonal design and central composite design/response surface method (CCD-RSM). METHODS: With the extraction rate of amygdalin as the index, the orthogonal experiment was adopted for the optimization of extraction process. With the film-forming time, spraying effect, thickness and maintain time of spray film as the indexes, the dosages of PVA 1788, PVP k30 and glycerin as factors, the prescription was optimized by CCD-RSM...
November 2015: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
https://www.readbyqxmd.com/read/27133300/chinese-medicine-cga-formula-ameliorates-dmn-induced-liver-fibrosis-in-rats-via-inhibiting-mmp2-9-timp1-2-and-the-tgf-%C3%AE-smad-signaling-pathways
#7
Xue-Mei Li, Jing-Hua Peng, Zhao-Lin Sun, Hua-Jie Tian, Xiao-Hua Duan, Lin Liu, Xin Ma, Qin Feng, Ping Liu, Yi-Yang Hu
AIM: Chinese medicine CGA formula consists of polysaccharide from Cordyceps sinensis mycelia (CS-PS), gypenosides and amygdalin, which is derived from Fuzheng Huayu (FZHY) capsule for treating liver fibrosis. In this study we attempted to confirm the therapeutic effects of CGA formula in dimethylnitrosamine (DMN)-induced liver fibrosis in rats, and to identify the mechanisms of anti-fibrotic actions. METHODS: Rats were injected with DMN (10 mg·kg(-1)·d(-1), ip) for 3 consecutive days per week over a 4-week period...
June 2016: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/27119432/application-of-the-prunus-spp-cyanide-seed-defense-system-onto-wheat-reduced-insect-feeding-and-field-growth-tests
#8
Carlos A Mora, Jonas G Halter, Cornel Adler, Andreas Hund, Heidrun Anders, Kang Yu, Wendelin J Stark
Many crops are ill-protected against insect pests during storage. To protect cereal grains from herbivores during storage, pesticides are often applied. While pesticides have an undoubtable functionality, increasing concerns are arising about their application. In the present study, we investigated a bioinspired cyanogenic grain coating with amygdalin as cyanogenic precursor mimicking the feeding-triggered release of hydrogen cyanide (HCN) found for example in bitter almonds. The multilayer coating consisted of biodegradable polylactic acid with individual layers containing amygdalin or β-glucosidase which is capable of degrading amygdalin to HCN...
May 11, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27021084/effects-of-amygdaline-from-apricot-kernel-on-transplanted-tumors-in-mice
#9
V A Yamshanov, E G Kovan'ko, Yu I Pustovalov
The effects of amygdaline from apricot kernel added to fodder on the growth of transplanted LYO-1 and Ehrlich carcinoma were studied in mice. Apricot kernels inhibited the growth of both tumors. Apricot kernels, raw and after thermal processing, given 2 days before transplantation produced a pronounced antitumor effect. Heat-processed apricot kernels given in 3 days after transplantation modified the tumor growth and prolonged animal lifespan. Thermal treatment did not considerably reduce the antitumor effect of apricot kernels...
March 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27002407/amygdalin-quackery-or-cure
#10
REVIEW
Roman A Blaheta, Karen Nelson, Axel Haferkamp, Eva Juengel
BACKGROUND: The cyanogenic diglucoside, amygdalin, has gained high popularity among cancer patients together with, or in place of, conventional therapy. Still, evidence based research on amygdalin is sparse and its benefit controversial. PURPOSE: Since so many cancer patients consume amygdalin, and many clinicians administer it without clear knowledge of its mode of action, current knowledge has been summarized and the pros and cons of its use weighed. METHODS: A retrospective analysis was conducted for amygdalin relevant reports using the PubMed database with the main search term "Amygdalin" or "laetrile", at times combined with "cancer", "patient", "cyanide" or "toxic"...
April 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/26983219/-in-vitro-microdialysis-recoveries-of-nine-active-ingredients-in-mahuang-decoction
#11
Ying-hong Tang, Hai-tong Wan, Jian-zhen Chen, Hui-fen Zhou, Yan-fang Tian, Yu He
To detect the in vitro probe microdialysis recoveries based on an HPLC-DAD method for simultaneous quantification of nine active ingredients (ephedrine, pseudoephedrine, methylephedrine, amygdalin, liquiritin, cinnamyl alcohol, cinnamic acid, cinnamaldehyde and glycyrrhizic acid) in Mahuang decoction, which provides reference for in vivo pharmacokinetic study. The concentrations of nine active ingredients in dialysate were detected by HPLC-DAD, to investigate the effect of flow rates (incremental method and subtraction method) and intraday stability of the probe recoveries and medium concentrations on the recoveries...
September 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/26837182/-an-lc-ms-ms-method-for-the-simultaneous-determination-of-amygdalin-and-paeoniflorin-in-human-urine-and-application-to-urinary-excretion-study
#12
Xiao-bing Li, Fu-guo Shi, Ling-yan Jian, Li Ding
The study aims to develop an LC-MS/MS method for the simultaneous determination of amygdalin and paeoniflorin in urine samples, and to investigate their urinary excretion characteristics in healthy volunteers after intravenous infusion administration of Huoxue-Tongluo lyophilized powder for injection (HTLPI). The urine samples were extracted by methanol, and then separated on a Hedera ODS-2 column with a mobile phase of acetonitrile and 5 mmol · L(-1) ammonium acetate buffer solution containing 0.05% formic acid (20:80)...
October 2015: Yao Xue Xue Bao, Acta Pharmaceutica Sinica
https://www.readbyqxmd.com/read/26827990/amygdalin-delays-cell-cycle-progression-and-blocks-growth-of-prostate-cancer-cells-in-vitro
#13
Jasmina Makarević, Igor Tsaur, Eva Juengel, Hendrik Borgmann, Karen Nelson, Christian Thomas, Georg Bartsch, Axel Haferkamp, Roman A Blaheta
AIMS: Despite impressive survival benefits from new agents to treat metastasized prostate cancer (PCa), progressive drug resistance hinders long-term response and restricts the efficacy of subsequent therapy. Due to reported antitumor activity of amygdalin and growing popularity for complementary and alternative medicine the potential of this natural, widely used substance to exert antineoplastic effects on prostate cancer cells has been assessed. MAIN METHODS: LNCaP (castration-sensitive), DU-145 and PC3 cells (castration-resistant) were exposed to different concentrations of amygdalin for 24h or 2weeks...
February 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/26781971/amygdalin-blocks-the-in-vitro-adhesion-and-invasion-of-renal-cell-carcinoma-cells-by-an-integrin-dependent-mechanism
#14
Eva Juengel, Masud Afschar, Jasmina Makarević, Jochen Rutz, Igor Tsaur, Jens Mani, Karen Nelson, Axel Haferkamp, Roman A Blaheta
Information about the natural compound amygdalin, which is employed as an antitumor agent, is sparse and thus its efficacy remains controversial. In this study, to determine whether amygdalin exerts antitumor effects on renal cell carcinoma (RCC) cells, its impact on RCC metastatic activity was investigated. The RCC cell lines, Caki-1, KTC-26 and A498, were exposed to amygdalin from apricot kernels, and adhesion to human vascular endothelium, immobilized collagen or fibronectin was investigated. The influence of amygdalin on chemotactic and invasive activity was also determined, as was the influence of amygdalin on surface and total cellular α and β integrin expression, which are involved in metastasis...
March 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/26709398/amygdalin-inhibits-the-growth-of-renal-cell-carcinoma-cells-in-vitro
#15
Eva Juengel, Anita Thomas, Jochen Rutz, Jasmina Makarevic, Igor Tsaur, Karen Nelson, Axel Haferkamp, Roman A Blaheta
Although amygdalin is used by many cancer patients as an antitumor agent, there is a lack of information on the efficacy and toxicity of this natural compound. In the present study, the inhibitory effect of amygdalin on the growth of renal cell carcinoma (RCC) cells was examined. Amygdalin (10 mg/ml) was applied to the RCC cell lines, Caki-1, KTC-26 and A498, for 24 h or 2 weeks. Untreated cells served as controls. Tumor cell growth and proliferation were determined using MTT and BrdU tests, and cell cycle phases were evaluated...
February 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/26697694/pharmacokinetics-of-maxing-shigan-decoction-in-normal-rats-and-rsv-pneumonia-model-rats-by-hplc-ms-ms
#16
Li Jiang, Meng Gao, Fei Qu, Hui-lan Li, Lan-bin Yu, Yi Rao, Yue-sheng Wang, Guo-liang Xu
To establish a LC-MS/MS method to determine the concentrations of liquiritin, glycyrrhizin, glycyrrhetinic acid, amygdalin, amygdalin prunasin, ephedrine, pseudoephedrine and methylephedrine of Maxing Shigan decoction in rat plasma, and study the differences on their pharmacokinetic process in normal rats and RSV pneumonia model rats. After normal rats and RSV pneumonia model rats were orally administered with Maxing Shigan decoction, the blood was collected from retinal vein plexus of different time points...
July 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/26681298/targeting-druggable-enzymome-by-exploiting-natural-medicines-an-in-silico-in-vitro-integrated-approach-to-combating-multidrug-resistance-in-bacterial-infection
#17
Ping Zang, Aijie Gong, Peirong Zhang, Jinling Yu
CONTEXT: Antibiotic resistance is a major clinical and public health problem. Development of new therapeutic approaches to prevent bacterial multidrug resistance during antimicrobial chemotherapy has thus been becoming a primary consideration in the medicinal chemistry community. OBJECTIVE: We described a new strategy that combats multidrug resistance by using natural medicines to target the druggable enzymome (i.e., enzymatic proteome) of Staphylococcus aureus...
2016: Pharmaceutical Biology
https://www.readbyqxmd.com/read/26588440/identification-of-key-active-constituents-of-buchang-naoxintong-capsules-with-therapeutic-effects-against-ischemic-stroke-by-using-an-integrative-pharmacology-based-approach
#18
Xu Haiyu, Shi Yang, Zhang Yanqiong, Jia Qiang, Li Defeng, Zhang Yi, Liu Feng, Yang Hongjun
Integrative pharmacology has been used to identify the key active constituents (KACs) of Buchang Naoxintong capsules (BNCs), a traditional Chinese medical preparation; this approach involves the evaluation of the content profiles and drug-like properties of the BNC constituents and development of an ingredient-target network. In this study, we used a sensitive analytical method to simultaneously identify and quantify 16 constituents of BNCs. Metabolism of these constituents by gut microbiota and human oral bioavailability were predicted using an in silico approach, followed by construction of networks to analyze the interactions between BNC constituents, their molecular targets, and proteins known to be the molecular targets for Food and Drug Administration-approved colitis medication...
January 2016: Molecular BioSystems
https://www.readbyqxmd.com/read/26552167/-application-of-microwave-technology-in-extraction-process-of-guizhi-fuling-capsule
#19
Zheng-kuan Wang, Mao Zhou, Yuan Liu, Yu-an Bi, Zhen-zhong Wang, Wei Xiao
In this paper, optimization of the conditions of microwave technique in extraction process of Guizhi Fuling capsule in the condition of a pilot scale was carried out. First of all, through the single factor experiment investigation of various factors, the overall impact tendency and range of each factor were determined. Secondly, L9 (3(4)) orthogonal test optimization was used, and the contents of gallic acid in liquid, paeoniflorin, benzoic acid, cinnamic acid, benzoyl paeoniflorin, amygdalin of the liquid medicine were detected...
June 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/26431391/problems-and-pitfalls-in-the-analysis-of-amygdalin-and-its-epimer
#20
M Farooq Wahab, Zachary S Breitbach, Daniel W Armstrong, Rick Strattan, Alain Berthod
α-[(6-O-β-d-Glucopyranosyl-β-d-glucopyranosyl)oxy]-(αR)-benzeneacetonitrile, or R-amygdalin, is the most common cyanogenic glycoside found in seeds and kernels of the Rosaceae family and other plant genera such as Passiflora. Many commercially important seeds are analyzed for amygdalin content. In "alternative medicine", amygdalin has been sold as a treatment for cancer for several decades without any rigorous scientific support for its efficacy. We have found that there are some inconsistencies and possible problems in the published analytical chemistry of amygdalin...
October 14, 2015: Journal of Agricultural and Food Chemistry
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