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Psychiatric medicinal plants

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https://www.readbyqxmd.com/read/29199234/the-seed-of-zizyphus-jujuba-var-spinosa-attenuates-alzheimer-s-disease-associated-hippocampal-synaptic-deficits-through-bdnf-trkb-signaling
#1
Huiyoung Kwon, In Ho Jung, Ji Hyun Yi, Jae Hoon Kim, Jung Hoon Park, Seungheon Lee, Ji Wook Jung, Young Choon Lee, Jong Hoon Ryu, Dong Hyun Kim
Ziziphus jujuba is a plant, which bears fruits and seeds that are used for medicinal purposes in Traditional oriental medicine. The seed of Zizyphus jujuba var. spinosa (EZJ) has been also traditionally used for psychiatric disorders in Chinese and Korean medicines. Recent findings have indicated that EZJ improves memory impairment, a common symptom of various neurological diseases. However, the effects of EZJ on amyloid β (Aβ) toxicity, which is a main cause of Alzheimer's disease (AD), remain to be elucidated...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28986178/neuropharmacological-and-acute-toxicological-evaluation-of-ethanolic-extract-of-allamanda-cathartica-l-flowers-and-plumieride
#2
Tiago J Bonomini, Iandra Holzmann, Liliani Carolini Thiesen, Eduarda Fratoni, Ana Flavia Fischer Muller, Ruth M Lucinda-Silva, Rosendo Augusto Yunes, Angela Malheiros, Ana Elisa Gonçalves, Ana Paula Dalmagro, Kathryn Ana Bortolini Simão da Silva, Márcia Maria de Souza, José Roberto Santin
Psychiatric diseases affect more than 350 million people all over the world, and medicinal plants have been considered the basis for pharmacological research. The study investigates the anticonvulsant and antidepressant-like activities and acute toxicological effects of ethanolic extract of Allamanda cathartica flowers, and plumieride. The extract was analyzed by HPLC and plumieride was isolated. Toxicity studies were carried out on females Wistar rats (2000 mg/kg). Toxicity was evaluated by measuring biochemical parameters and conducting histopathological analysis...
October 4, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28951674/prevalence-of-self-medication-practice-with-herbal-products-among-non-psychotic-psychiatric-patients-from-southeastern-serbia-a-cross-sectional-study
#3
Nikola M Stojanović, Ljiljana Samardžić, Pavle J Randjelović, Niko S Radulović
The aim of this study was to evaluate the usage prevalence of herbal products (HP) and to ascertain the identity, mode and adverse effects of plant taxa used in self-medication practice for anxiety, depression and insomnia in patients with non-psychotic disorders originating from southeastern Serbia. Also, we compared HP users and non-users on the variables of socio-demographic characteristics, information source and origin of HP. The study was done by a face-to-face interview with a trained psychiatrist using a structured questionnaire administered to 136 adult patients suffering from non-psychotic mental disorders...
September 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28930246/medicinal-plants-used-for-neuropsychiatric-disorders-treatment-in-the-hauts-bassins-region-of-burkina-faso
#4
Prosper T Kinda, Patrice Zerbo, Samson Guenné, Moussa Compaoré, Alin Ciobica, Martin Kiendrebeogo
Background: In Burkina Faso, phytotherapy is the main medical alternative used by populations to manage various diseases that affect the nervous system. The aim of the present study was to report medicinal plants with psychoactive properties used to treat neuropsychiatric disorders in the Hauts Bassins region, in the western zone of Burkina Faso. Methods: Through an ethnobotanical survey using structured questionnaire, 53 traditional healers (TH) were interviewed about neuropsychiatric disorders, medicinal plants and medical practices used to treat them...
May 19, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28289385/plant-derived-phytocompound-embelin-in-cns-disorders-a-systematic-review
#5
REVIEW
Uday P Kundap, Saatheeyavaane Bhuvanendran, Yatinesh Kumari, Iekhsan Othman, Mohd Farooq Shaikh
A Central nervous system (CNS) disease is the one which affects either the spinal cord or brain and causing neurological or psychiatric complications. During the nineteenth century, modern medicines have occupied the therapy for many ailments and are widely used these days. Herbal medicines have often maintained popularity for historical and cultural reasons and also considered safer as they originate from natural sources. Embelin is a plant-based benzoquinone which is the major active constituent of the fruits of Embelia ribes Burm...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28145043/objective-measures-of-sleep-duration-and-continuity-in-major-depressive-disorder-with-comorbid-hypersomnolence-a-primary-investigation-with-contiguous-systematic-review-and-meta-analysis
#6
REVIEW
David T Plante, Jesse D Cook, Michael R Goldstein
Hypersomnolence plays an important role in the presentation, treatment and course of mood disorders. However, there has been relatively little research that examines objective measures of sleep duration and continuity in patients with depression and hypersomnolence, despite the use of these factors in sleep medicine nosological systems. This study compared total sleep time and efficiency measured by naturalistic actigraphic recordings followed by ad libitum polysomnography (PSG; without prescribed wake time) in 22 patients with major depressive disorder and co-occurring hypersomnolence against age- and sex-matched healthy sleeper controls...
June 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/27908257/ginkgo-biloba-as-an-alternative-medicine-in-the-treatment-of-anxiety-in-dementia-and-other-psychiatric-disorders
#7
Sandeep Kumar Singh, George E Barreto, Gjumrakch Aliev, Valentina Echeverria
BACKGROUND: Mental disorders are the most common health problems in the worldwide population. Current medicines against these conditions have undesired side effects or limited effectiveness. These disadvantageous pharmacological and therapeutic characteristics provoke a low adherence to treatment in an important percentage of patients with mental disorders. Since ancient times, ethnically different groups have been using plants extracts as medicines for the treatment of mental conditions including dementia, depression and anxiety disorders...
2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/27804869/advances-in-medicinal-plants-with-effects-on-anxiety-behavior-associated-to-mental-and-health-conditions
#8
REVIEW
George E Barreto, Marco Avila-Rodriguez, Madeline Foitzick, Gjumrakch Aliev, Valentina Echeverria
BACKGROUND: Many mental health conditions including psychiatric disorders and neurodegenerative conditions are poorly responsive for actual medications or have low patient adherence to treatment due to the side effects or costs associated with these treatments. OBJECTIVE: The main goal of this review is to provide clinical providers and patients with actualized information about the efficacy of selected herbal medicines for anxiety disorders derived from mental and/or health conditions, and their associated side effects...
2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27516197/flavonoids-in-neurodegeneration-limitations-and-strategies-to-cross-cns-barriers
#9
Paula Branquinho Andrade, Clara Grosso, Patrícia Valentao, Joao Bernardo
The central nervous system (CNS) is a mythical target for drug delivery. There is an ongoing debate over the brain accessibility of flavonoids, a group of plant-derived secondary metabolites widely known by their multifarious bioactivities achieved by distinct mechanisms. Recently, their applicability in the management of neurologic and psychiatric disorders, such as Alzheimer's and Parkinson's diseases, and major depression, has received particular attention. To reach their target, flavonoids must cross over the ultimate obstacle - the blood-brain barrier - at pharmacologically effective concentrations...
2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27413390/sedative-and-anxiolytic-like-actions-of-ethanol-extract-of-leaves-of-glinus-oppositifolius-linn-aug-dc
#10
Md Moniruzzaman, Partha Sharoti Bhattacharjee, Moushumi Rahman Pretty, Md Sarwar Hossain
Glinus oppositifolius is a small herb, widely used in the traditional medicine of Bangladesh in treatment of a variety of diseases and disorders such as insomnia, pain, inflammation, jaundice, and fever. The present study evaluated the sedative and anxiolytic potentials of the ethanol extract of leaves of G. oppositifolius (EEGO) in different behavioral models in mice. The sedative activity of EEGO was investigated using hole cross, open field, rotarod, and thiopental sodium- (TS-) induced sleeping time determination tests, where the elevated plus maze (EPM) and light-dark box (LDB) exploration tests were employed to justify the anxiolytic potentials in mice at the doses of 50, 100, and 200 mg/kg...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27281332/phytochemicals-potential-in-management-of-climacteric-neurobiology
#11
REVIEW
Kanwaljit Chopra, Seema Bansal, Anand Kamal Sachdeva
Menopause jeopardizes the integrity of brain and makes it vulnerable to various diseases, both of psychiatric and degenerative nature. Exogenous estrogen supplementation confers neuroprotection but the results of Women's Health Initiative (WHI), Million Women Study (MWS) and incidence of endometrial cancer, breast cancer and venous thromboembolism reported with estrogen use have engendered doubts over its clinical translation for postmenopausal neurological disorders. Scientific community and general public have started recognizing the protective potential of phytochemicals in climacteric medicine...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27021688/mexican-medicinal-plants-with-anxiolytic-or-antidepressant-activity-focus-on-preclinical-research
#12
REVIEW
Carolina López-Rubalcava, Erika Estrada-Camarena
ETHNOPHARMACOLOGICAL RELEVANCE: Anxiety and depression are considered the most prevalent psychiatric disorders worldwide. In Mexico, the use of medicinal plants to alleviate the symptoms associated with these psychiatric disorders is increasing. However, there is little scientific evidence that validates the efficacy of these plants. This evidence needs to be critically revised, and further studied to provided scientific support for their use. AIM OF THE STUDY: To identify the plants that are used in Mexico for the treatment of disorders related to anxiety and depression, and to review the current preclinical and when available, clinical information of these plants...
June 20, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/26950102/constituents-of-saffron-crocus-sativus-l-as-potential-candidates-for-the-treatment-of-anxiety-disorders-and-schizophrenia
#13
REVIEW
Nikolaos Pitsikas
Anxiety disorders and schizophrenia are common public health issues. The dried stigma of the plant Crocus sativus L., (C. sativus) commonly known as saffron are used in folk medicine for various purposes. Several lines of evidence suggest that C. sativus, crocins and safranal are implicated in anxiety and schizophrenia. Here, I intend to critically review advances in research of these emerging molecules for the treatment of anxiety and schizophrenia, discuss their advantages over currently used anxiolytics and neuroleptics, as well remaining challenges...
March 2, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/26883161/sleep-propensity-in-psychiatric-hypersomnolence-a-systematic-review-and-meta-analysis-of-multiple-sleep-latency-test-findings
#14
REVIEW
David T Plante
Hypersomnolence plays a sizeable role in the course and morbidity of psychiatric disorders. Current sleep medicine nosology is reliant on the multiple sleep latency test (MSLT) to segregate hypersomnolence associated with psychiatric disorders from other central nervous system causes. However, the evidence base regarding sleep propensity in psychiatric hypersomnolence as measured by the MSLT has not been systematically evaluated, which is vital to clarify the utility and validity of current nosological schema...
February 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/26851117/treatment-of-anxiety-and-depression-medicinal-plants-in-retrospect
#15
REVIEW
James O Fajemiroye, Dayane M da Silva, Danillo R de Oliveira, Elson A Costa
Anxiety and depression are complex heterogeneous psychiatric disorders and leading causes of disability worldwide. This review summarizes reports on the fundamentals, prevalence, diagnosis, neurobiology, advancement in treatment of these diseases and preclinical assessment of botanicals. This review was conducted through bibliographic investigation of scientific journals, books, electronic sources, unpublished theses and electronic medium such as ScienceDirect and PubMed. A number of the first-line drugs (benzodiazepine, azapirone, antidepressant tricyclics, monoamine oxidase inhibitors, serotonin selective reuptake inhibitors, noradrenaline reuptake inhibitors, serotonin and noradrenaline reuptake inhibitors, etc...
June 2016: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/26830780/-efficacy-tolerability-and-safety-of-cannabinoids-for-chronic-neuropathic-pain-a-systematic-review-of-randomized-controlled-studies
#16
REVIEW
F Petzke, E K Enax-Krumova, W Häuser
BACKGROUND: Recently published systematic reviews came to different conclusions with respect to the efficacy, tolerability and safety of cannabinoids for treatment of chronic neuropathic pain. MATERIAL AND METHODS: A systematic search of the literature was carried out in MEDLINE, the Cochrane central register of controlled trials (CENTRAL) and clinicaltrials.gov up until November 2015. We included double-blind randomized placebo-controlled studies (RCT) of at least 2 weeks duration and with at least 9 patients per treatment arm comparing medicinal cannabis, plant-based or synthetic cannabinoids with placebo or any other active drug treatment in patients with chronic neuropathic pain...
February 2016: Der Schmerz
https://www.readbyqxmd.com/read/26409901/botanicals-for-mood-disorders-with-a-focus-on-epilepsy
#17
REVIEW
Germain Jean Magloire Ketcha Wanda, Steve Guemnang Ngitedem, Dieudonné Njamen
Mood disorders are among the major health problems that exist worldwide. They are highly prevalent in the general population and cause significant disturbance of life quality and social functioning of the affected persons. The two major classes of mood disorders are bipolar disorders and depression. The latter is assumed to be the most frequent psychiatric comorbidity in epilepsy. Studies published during the second half of the 20th century recognized that certain patients with epilepsy present a depressed mood...
November 2015: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/26253688/from-covalent-bonds-to-eco-physiological-pharmacology-of-secondary-plant-metabolites
#18
REVIEW
Shyam Sunder Chatterjee
Despite the availability of numerous drugs and other therapeutic modalities, the prevention and cure of over- and under-nutrition triggered metabolic and other disease states continues as a major challenge for modern medicine. Such silently progressing and eventually life-threatening diseases often accompany diverse spectrum of comorbid psychiatric disorders. Majority of the global population suffering from metabolic diseases live in economically developing or underdeveloped countries, where due to socioeconomic, cultural, and other reasons, therapies may be unavailable...
November 15, 2015: Biochemical Pharmacology
https://www.readbyqxmd.com/read/26035960/psychopharmacological-potentials-of-methanol-leaf-extract-of-securinega-virosa-roxb-ex-willd-baill-in-mice
#19
M G Magaji, Y Yakubu, R A Magaji, A M Musa, A H Yaro, I M Hussaini
Schizophrenia is a highly disabling chronic psychiatric illness. The existing antipsychotic agents are associated with untoward effects and drug interactions leading to the intensification of search for newer agents with better efficacy and safety profile. Securinega virosa is a commonly used medicinal plant in African traditional medicine. The decoction of the leaves of the plant in combination with other plants is used in the management of mental illness. In this study, we evaluate the antipsychotic potential of the methanol leaf extract (25, 50 and 100 mg kg(-1)) of the plant using apomorphine-induced stereotypic climbing behavior and swim-induced grooming tests, all in mice...
June 2014: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/25856437/revealing-medicinal-plants-that-are-useful-for-the-comprehensive-management-of-epilepsy-and-associated-comorbidities-through-in-silico-mining-of-their-phytochemical-diversity
#20
Rajesh Kumar Goel, Dinesh Gawande, Alexey Lagunin, Puneet Randhawa, Awanish Mishra, Vladimir Poroikov
In silico techniques in drug discovery may rationalise and speed up the identification of lead molecules from nature. Drug discovery from medicinal plants has mostly been confined to indications in accordance with their ethnical use only. However, the availability of multiple phytoconstituents in medicinal plants suggests that these may be much more useful beyond their traditional uses and in the management of chronic diseases, along with their comorbidities. In this study, the computer programmes PASS and PharmaExpert were used to reveal the medicinal plants useful in the comprehensive management of epilepsy and associated psychiatric disorders based on the pleiotropic effects predicted for their phytoconstituents...
April 2015: Planta Medica
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