keyword
MENU ▼
Read by QxMD icon Read
search

Glycine health

keyword
https://www.readbyqxmd.com/read/28444884/novel-urinary-alkylresorcinol-metabolites-as-biomarkers-of-whole-grain-intake-in-free-living-swedish-adults
#1
Roksana Wierzbicka, Galia Zamaratskaia, Afaf Kamal-Eldin, Rikard Landberg
SCOPE: Most studies on the role of whole grain for health rely on self-reported intake data, which are prone to measurement errors. There is a need for dietary biomarkers that can provide an objective measure of intake. Alkylresorcinols (AR) and their main metabolites 3,5-dihydroxybenzoic acid (DHBA) and 3-(3,5-dihydroxyphenyl)-propanoic acid (DHPPA) have been proposed as biomarkers for whole grain (WG) wheat and rye intake. METHODS AND RESULTS: The medium-term reproducibility and relative validity of four putative urinary AR metabolites (3,5-dihydroxycinnamic acid (DHCA), 5-(3,5-dihydroxyphenyl) pentanoic acid (DHPPTA), 2-(3,5-dihydroxybenzamido)acetic acid (DHBA-glycine) and 3,5-dihydroxycinnamic acid amide (DHCA-amide)) as biomarkers for WG intake were investigated...
April 26, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28400591/pathogenicity-and-transmission-of-a-swine-influenza-a-h6n6-virus
#2
Hailiang Sun, Bryan S Kaplan, Minhui Guan, Guihong Zhang, Jianqiang Ye, Li-Ping Long, Sherry Blackmon, Chun-Kai Yang, Meng-Jung Chiang, Hang Xie, Nan Zhao, Jim Cooley, David F Smith, Ming Liao, Carol Cardona, Lei Li, George Peng Wang, Richard Webby, Xiu-Feng Wan
Subtype H6 influenza A viruses (IAVs) are commonly detected in wild birds and domestic poultry and can infect humans. In 2010, a H6N6 virus emerged in southern China, and since then, it has caused sporadic infections among swine. We show that this virus binds to α2,6-linked and α2,3-linked sialic acids. Mutations at residues 222 (alanine to valine) and 228 (glycine to serine) of the virus hemagglutinin (HA) affected its receptor-binding properties. Experiments showed that the virus has limited transmissibility between ferrets through direct contact or through inhalation of infectious aerosolized droplets...
April 12, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28397230/-identification-of-a-novel-hla-allele-hla-b-46-01-18
#3
Yongfeng Pei, Huini Huang, Hengcong Li, Weidong Shen
OBJECTIVE: To report on a novel human leukocyte antigen (HLA) allele. METHODS: Polymerase chain reaction-sequence based typing was used for routine HLA typing. For one sample, the result of B locus typing showed mismatch of one base with B*46:01:01, B*15:25:01 at locus 384. The group specific sequencing primers, which target at B*46 and B*15, were used to confirm the difference between the novel allele and the highest homologous allele. RESULTS: The sequencing results showed that the highest homologous allele to the novel allele was B*46:01:01...
April 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/28388932/the-efficacy-of-sodium-benzoate-as-an-adjunctive-treatment-in-early-psychosis-cadence-bz-study-protocol-for-a-randomized-controlled-trial
#4
Alex Ryan, Andrea Baker, Frances Dark, Sharon Foley, Anne Gordon, Sean Hatherill, Stephen Stathis, Sukanta Saha, George Bruxner, Martin Beckman, Drew Richardson, Michael Berk, Olivia Dean, John McGrath, Cadence Working Group, James Scott
BACKGROUND: Psychotic disorders affect up to 3% of the population and are often chronic and disabling. Innovation in the pharmacological treatment of psychosis has remained stagnant in recent decades. In order to improve outcomes for those with psychotic disorders, we present a protocol for the trial of a common food preservative, sodium benzoate, as an adjunctive treatment in early psychosis. METHODS: Persons experiencing early psychosis (n = 160) will be recruited through hospitals and community mental health services in Queensland, Australia...
April 7, 2017: Trials
https://www.readbyqxmd.com/read/28375879/glycine-metabolism-in-skeletal-muscle-implications-for-metabolic-homeostasis
#5
René Koopman, Marissa K Caldow, Daniel J Ham, Gordon S Lynch
PURPOSE OF REVIEW: The review summarizes the recent literature on the role of glycine in skeletal muscle during times of stress. RECENT FINDINGS: Supplemental glycine protects muscle mass and function under pathological conditions. In addition, mitochondrial dysfunction in skeletal muscle leads to increased cellular serine and glycine production and activation of NADPH-generating pathways and glutathione metabolism. These studies highlight how glycine availability modulates cellular homeostasis and redox status...
April 3, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/28350402/metabolomics-approach-for-multibiomarkers-determination-to-investigate-dengue-virus-infection-in-human-patients
#6
Nurul Shahfiza, Hasnah Osman, Tang Thean Hock, Abdel-Hamid Zaki Abdel-Hamid
BACKGROUND: Dengue is one of the major public health problems in the world, affecting more than fifty million cases in tropical and subtropical region every year. The metabolome, as pathophysiological end-points, provide significant understanding of the mechanism and progression of dengue pathogenesis via changes in the metabolite profile of infected patients. Recent developments in diagnostic technologies provide metabolomics for the early detection of infectious diseases. METHODS: The mid-stream urine was collected from 96 patients diagnosed with dengue fever at Penang General Hospital (PGH) and 50 healthy volunteers...
March 30, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/28337245/multifarious-beneficial-effect-of-nonessential-amino-acid-glycine-a-review
#7
REVIEW
Meerza Abdul Razak, Pathan Shajahan Begum, Buddolla Viswanath, Senthilkumar Rajagopal
Glycine is most important and simple, nonessential amino acid in humans, animals, and many mammals. Generally, glycine is synthesized from choline, serine, hydroxyproline, and threonine through interorgan metabolism in which kidneys and liver are the primarily involved. Generally in common feeding conditions, glycine is not sufficiently synthesized in humans, animals, and birds. Glycine acts as precursor for several key metabolites of low molecular weight such as creatine, glutathione, haem, purines, and porphyrins...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28330481/diverse-characteristics-of-the-urinary-excretion-of-amino-acids-in-humans-and-the-use-of-amino-acid-supplementation-to-reduce-fatigue-and-sub-health-in-adults
#8
R H Dunstan, D L Sparkes, M M Macdonald, X Janse De Jonge, B J Dascombe, J Gottfries, C-G Gottfries, T K Roberts
BACKGROUND: The excretion of amino acids in urine represents an important avenue for the loss of key nutrients. Some amino acids such as glycine and histidine are lost in higher abundance than others. These two amino acids perform important physiological functions and are required for the synthesis of key proteins such as haemoglobin and collagen. METHODS: Stage 1 of this study involved healthy subjects (n = 151) who provided first of the morning urine samples and completed symptom questionnaires...
March 23, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28259021/gas-chromatography-mass-spectrometry-profiles-of-urinary-organic-acids-in-healthy-captive-cheetahs-acinonyx-jubatus
#9
Adrian Stephen Wolferstan Tordiffe, Mari van Reenen, Fred Reyers, Lodewyk Jacobus Mienie
In captivity, cheetahs (Acinonyx jubatus) frequently suffer from several unusual chronic diseases that rarely occur in their free-ranging counterparts. In order to develop a better understanding of their metabolism and health we documented the urine organic acids of 41 apparently healthy captive cheetahs, in an untargeted metabolomic study, using gas chromatography-mass spectrometry. A total of 339 organic acids were detected and annotated. Phenolic compounds, thought to be produced by the anaerobic fermentation of aromatic amino acids in the distal colon, as well as their corresponding glycine conjugates, were present in high concentrations...
April 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28238459/linking-sources-to-early-effects-by-profiling-urine-metabolome-of-residents-living-near-oil-refineries-and-coal-fired-power-plants
#10
Chi-Hsin Sally Chen, Tzu-Hsuen Yuan, Ruei-Hao Shie, Kuen-Yuh Wu, Chang-Chuan Chan
BACKGROUND: This study aims at identifying metabolic changes linking external exposure to industrial air toxics with oxidative stress biomarkers. METHODS: We classified 252 study subjects as 111 high vs. 141 low exposure subjects by the distance from their homes to the two main emission sources, oil refineries and coal-fired power plants. We estimated individual's external exposure to heavy metals and polycyclic aromatic hydrocarbons (PAHs) by dispersion and kriging models, respectively...
February 23, 2017: Environment International
https://www.readbyqxmd.com/read/28221984/postharvest-reduction-of-coliphage-ms2-from-romaine-lettuce-during-simulated-commercial-processing-with-and-without-a-chlorine-based-sanitizer
#11
Samantha L Wengert, Tiong Gim Aw, Elliot T Ryser, Joan B Rose
Viral foodborne outbreaks are a serious threat to public health, and fresh produce is becoming increasingly recognized as a transmission vehicle. To limit foodborne disease, ready-to-eat leafy greens are typically washed with a chlorine-based sanitizer during commercial production. This study assessed the efficacy of a chlorine-based sanitizer against coliphage MS2, as a potential surrogate for foodborne viruses, on fresh-cut romaine lettuce during simulated commercial production using a small-scale processing line...
February 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28188896/alteration-of-neurotransmission-and-skeletogenesis-in-sea-urchin-arbacia-lixula-embryos-exposed-to-copper-oxide-nanoparticles
#12
Tiziana Cappello, Valeria Vitale, Sabrina Oliva, Valentina Villari, Angela Mauceri, Salvatore Fasulo, Maria Maisano
The extensive use of copper oxide nanoparticles (CuO NPs) in many applications has raised concerns over their toxicity on environment and human health. Herein, the embryotoxicity of CuO NPs was assessed in the black sea urchin Arbacia lixula, an intertidal species commonly present in the Mediterranean. Fertilized eggs were exposed to 0.7, 10 and 20ppb of CuO NPs, until pluteus stage. Interferences with the normal neurotransmission pathways were observed in sea urchin embryos. In detail, evidence of cholinergic and serotoninergic systems affection was revealed by dose-dependent decreased levels of choline and N-acetyl serotonin, respectively, measured by nuclear magnetic resonance (NMR)-based metabolomics, applied for the first time to our knowledge on sea urchin embryos...
February 7, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28167213/metagenomics-approach-to-the-study-of-the-gut-microbiome-structure-and-function-in-zebrafish-danio-rerio-fed-with-gluten-formulated-diet
#13
Hyunmin Koo, Joseph A Hakim, Mickie L Powell, Ranjit Kumar, Peter G Eipers, Casey D Morrow, Michael Crowley, Elliot J Lefkowitz, Stephen A Watts, Asim K Bej
In this study, we report the gut microbial composition and predictive functional profiles of zebrafish, Danio rerio, fed with a control formulated diet (CFD), and a gluten formulated diet (GFD) using a metagenomics approach and bioinformatics tools. The microbial communities of the GFD-fed D. rerio displayed heightened abundances of Legionellales, Rhizobiaceae, and Rhodobacter, as compared to the CFD-fed counterparts. Predicted metagenomics of microbial communities (PICRUSt) in GFD-fed D. rerio showed KEGG functional categories corresponding to bile secretion, secondary bile acid biosynthesis, and the metabolism of glycine, serine, and threonine...
February 3, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28115846/preparation-of-arginine-glycine-aspartic-acid-modified-biopolymeric-nanoparticles-containing-epigalloccatechin-3-gallate-for-targeting-vascular-endothelial-cells-to-inhibit-corneal-neovascularization
#14
Che-Yi Chang, Ming-Chen Wang, Takuya Miyagawa, Zhi-Yu Chen, Feng-Huei Lin, Ko-Hua Chen, Guei-Sheung Liu, Ching-Li Tseng
Neovascularization (NV) of the cornea can disrupt visual function, causing ocular diseases, including blindness. Therefore, treatment of corneal NV has a high public health impact. Epigalloccatechin-3-gallate (EGCG), presenting antiangiogenesis effects, was chosen as an inhibitor to treat human vascular endothelial cells for corneal NV treatment. An arginine-glycine-aspartic acid (RGD) peptide-hyaluronic acid (HA)-conjugated complex coating on the gelatin/EGCG self-assembly nanoparticles (GEH-RGD NPs) was synthesized for targeting the αvβ3 integrin on human umbilical vein endothelial cells (HUVECs) in this study, and a corneal NV mouse model was used to evaluate the therapeutic effect of this nanomedicine used as eyedrops...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28115703/complementary-roles-of-gasotransmitters-co-and-h2s-in-sleep-apnea
#15
Ying-Jie Peng, Xiuli Zhang, Anna Gridina, Irina Chupikova, David L McCormick, Robert J Thomas, Thomas E Scammell, Gene Kim, Chirag Vasavda, Jayasri Nanduri, Ganesh K Kumar, Gregg L Semenza, Solomon H Snyder, Nanduri R Prabhakar
Sleep apnea, which is the periodic cessation of breathing during sleep, is a major health problem affecting over 10 million people in the United States and is associated with several sequelae, including hypertension and stroke. Clinical studies suggest that abnormal carotid body (CB) activity may be a driver of sleep apnea. Because gaseous molecules are important determinants of CB activity, aberrations in their signaling could lead to sleep apnea. Here, we report that mice deficient in heme oxygenase-2 (HO-2), which generates the gaseous molecule carbon monoxide (CO), exhibit sleep apnea characterized by high apnea and hypopnea indices during rapid eye movement (REM) sleep...
February 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28111353/gc-ms-based-metabolomics-identifies-an-amino-acid-signature-of-acute-ischemic-stroke
#16
Dian Wang, Jing Kong, Jiayan Wu, Xingxing Wang, Minchao Lai
Ischemic stroke is a serious public health problem worldwide. Here, we characterized the metabolite features of acute ischemic stroke (AIS) using a gas chromatography-mass spectrometry-based metabolomics. Forty AIS patients and 29 sex and age-matched controls were recruited. The serum metabolic profiles were significantly different between the two groups. Compared to the controls, the patients had elevated levels of lactate, carbonate and glutamate (P<0.01), and lowered levels of alanine, citrate, glycine, isoleucine, leucine, serine, tyrosine, methionine, tryptophan, erythronic acid, urea, purine, hypoxanthine, and proline in the serum (P<0...
March 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28071805/antioxidant-and-chelating-capacity-of-maillard-reaction-products-in-amino-acid-sugar-model-systems-applications-for-food-processing
#17
Blanca A Mondaca-Navarro, Luz A Ávila-Villa, Aarón F González-Córdova, Jaime López-Cervantes, Dalia I Sánchez-Machado, Olga N Campas-Baypoli, Roberto Rodríguez-Ramírez
BACKGROUND: Maillard reaction products (MRP) have gained increasing interest owing to their both positive and negative effects on human health. Aqueous amino acid-sugar model systems were studied in order to evaluate the antioxidant and chelating activity of MRP under conditions similar to those of food processing. Amino acids (cysteine, glycine, isoleucine and lysine) combined with different sugars (fructose or glucose) were heated to 100 and 130 °C for 30, 60 and 90 min. Antioxidant capacity was evaluated via ABTS and DPPH free radical scavenging assays, in addition to Fe(2+) and Cu(2+) ion chelating capacity...
January 10, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28056769/a-genome-wide-association-study-of-seed-composition-traits-in-wild-soybean-glycine-soja
#18
Larry J Leamy, Hengyou Zhang, Changbao Li, Charles Y Chen, Bao-Hua Song
BACKGROUND: Cultivated soybean (Glycine max) is a major agricultural crop that provides a crucial source of edible protein and oil. Decreased amounts of saturated palmitic acid and increased amounts of unsaturated oleic acid in soybean oil are considered optimal for human cardiovascular health and therefore there has considerable interest by breeders in discovering genes affecting the relative concentrations of these fatty acids. Using a genome-wide association (GWA) approach with nearly 30,000 single nucleotide polymorphisms (SNPs), we investigated the genetic basis of protein, oil and all five fatty acid levels in seeds from a sample of 570 wild soybeans (Glycine soja), the progenitor of domesticated soybean, to identify quantitative trait loci (QTLs) affecting these seed composition traits...
January 5, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28025595/transcript-polymorphism-rates-in-soybean-seed-tissue-are-increased-in-a-single-transformant-of-glycine-max
#19
Kevin C Lambirth, Adam M Whaley, Jessica A Schlueter, Kenneth J Piller, Kenneth L Bost
Transgenic crops have been utilized for decades to enhance agriculture and more recently have been applied as bioreactors for manufacturing pharmaceuticals. Recently, we investigated the gene expression profiles of several in-house transgenic soybean events, finding one transformant group to be consistently different from our controls. In the present study, we examined polymorphisms and sequence variations in the exomes of the same transgenic soybean events. We found that the previously dissimilar soybean line also exhibited markedly increased levels of polymorphisms within mRNA transcripts from seed tissue, many of which are classified as gene expression modifiers...
2016: International Journal of Plant Genomics
https://www.readbyqxmd.com/read/27988416/energy-metabolism-and-metabolomics-response-of-pacific-white-shrimp-litopenaeus-vannamei-to-sulfide-toxicity
#20
Tongyu Li, Erchao Li, Yantong Suo, Zhixin Xu, Yongyi Jia, Jian G Qin, Liqiao Chen, Zhimin Gu
The toxicity and poisoning mechanisms of sulfide were studied in Litopenaeus vannamei from the perspective of energy metabolism and metabolomics. The lethal concentrations of sulfide in L. vannamei (LC50) at 24h, 48h, 72h, and 96h were determined. Sulfide at a concentration of 0, 1/10 (425.5μg/L), and 1/5 (851μg/L) of the LC50 at 96h was used to test the metabolic responses of L. vannamei for 21days. The chronic exposure of shrimp to a higher sulfide concentration of 851μg/L decreased shrimp survival but did not affect weight gain or the hepatopancreas index...
February 2017: Aquatic Toxicology
keyword
keyword
81307
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"