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Glycine health

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https://www.readbyqxmd.com/read/29196695/legume-crop-rotation-suppressed-nitrifying-microbial-community-in-a-sugarcane-cropping-soil
#1
Chanyarat Paungfoo-Lonhienne, Weijin Wang, Yun Kit Yeoh, Neil Halpin
Nitrifying microorganisms play an important role in nitrogen (N) cycling in agricultural soils as nitrification leads to accumulation of nitrate (NO3-) that is readily lost through leaching and denitrification, particularly in high rainfall regions. Legume crop rotation in sugarcane farming systems can suppress soil pathogens and improve soil health, but its effects on soil nitrifying microorganisms are not well understood. Using shotgun metagenomic sequencing, we investigated the impact of two legume break crops, peanut (Arachis hypogaea) and soybean (Glycine max), on the nitrifying communities in a sugarcane cropping soil...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29168569/point-of-use-fortification-of-foods-with-micronutrient-powders-containing-iron-in-children-of-preschool-and-school-age
#2
REVIEW
Luz Maria De-Regil, Maria Elena D Jefferds, Juan Pablo Peña-Rosas
BACKGROUND: Approximately 600 million children of preschool and school age are anaemic worldwide. It is estimated that at least half of the cases are due to iron deficiency. Point-of-use fortification of foods with micronutrient powders (MNP) has been proposed as a feasible intervention to prevent and treat anaemia. It refers to the addition of iron alone or in combination with other vitamins and minerals in powder form, to energy-containing foods (excluding beverages) at home or in any other place where meals are to be consumed...
November 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29165113/alteration-in-plasma-free-amino-acid-levels-and-its-association-with-gout
#3
M H Mahbub, Natsu Yamaguchi, Hidekazu Takahashi, Ryosuke Hase, Hiroki Amano, Mikiko Kobayashi-Miura, Hideyuki Kanda, Yasuyuki Fujita, Hiroshi Yamamoto, Mai Yamamoto, Shinya Kikuchi, Atsuko Ikeda, Naoko Kageyama, Mina Nakamura, Yasutaka Ishimaru, Hiroshi Sunagawa, Tsuyoshi Tanabe
BACKGROUND: Studies on the association of plasma-free amino acids with gout are very limited and produced conflicting results. Therefore, we sought to explore and characterize the plasma-free amino acid (PFAA) profile in patients with gout and evaluate its association with the latter. METHODS: Data from a total of 819 subjects (including 34 patients with gout) undergoing an annual health examination program in Shimane, Japan were considered for this study. Venous blood samples were collected from the subjects and concentrations of 19 plasma amino acids were determined by high-performance liquid chromatography-electrospray ionization-mass spectrometry...
March 16, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29153530/physicochemical-and-sensory-properties-of-yogurts-containing-sacha-inchi-plukenetia-volubilis-l-seeds-and-%C3%AE-glucans-from-ganoderma-lucidum
#4
Ana-Milena Vanegas-Azuero, Luis-Felipe Gutiérrez
Dairy products have been widely used for adding various biomolecules with the aim of improving their functional properties and health benefits. In this study, the physicochemical properties and sensory acceptance of yogurts enriched with sacha inchi (Plukenetia volubilis) seeds (SIS) and β-glucans from Ganoderma lucidum (BGGL) were investigated. The angiotensin-converting enzyme-inhibitory activity of some yogurt samples was also evaluated. Yogurts were produced from reconstituted skim milk powder, and SIS (4% wt/wt) and BGGL were added at different concentrations (0-1...
November 15, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29126807/post-exposure-immunization-by-capsid-modified-adc7-vector-expressing-pseudomonas-aeruginosa-oprf-clears-p-aeruginosa-respiratory-infection
#5
Rika Gomi, Anurag Sharma, Wenzhu Wu, Biin Sung, Stefan Worgall
Respiratory infections with Pseudomonas aeruginosa are major health problems, particularly in patients with cystic fibrosis (CF). No vaccine against P. aeruginosa is yet available. A vaccine that controls colonization of the respiratory tract with P. aeruginosa could be useful to prevent chronic infection and exacerbations. Replication-deficient adenoviral (Ad) vectors based on non-human serotypes are attractive vaccine platforms as they can circumvent the problem of pre-existing anti-Ad immunity in humans...
November 7, 2017: Vaccine
https://www.readbyqxmd.com/read/29117584/environmental-and-health-effects-of-the-herbicide-glyphosate
#6
REVIEW
A H C Van Bruggen, M M He, K Shin, V Mai, K C Jeong, M R Finckh, J G Morris
The herbicide glyphosate, N-(phosphonomethyl) glycine, has been used extensively in the past 40years, under the assumption that side effects were minimal. However, in recent years, concerns have increased worldwide about the potential wide ranging direct and indirect health effects of the large scale use of glyphosate. In 2015, the World Health Organization reclassified glyphosate as probably carcinogenic to humans. A detailed overview is given of the scientific literature on the movement and residues of glyphosate and its breakdown product aminomethyl phosphonic acid (AMPA) in soil and water, their toxicity to macro- and microorganisms, their effects on microbial compositions and potential indirect effects on plant, animal and human health...
November 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29101857/interaction-transformation-and-toxicity-assessment-of-particles-and-additives-used-in-the-semiconducting-industry
#7
Eduard Dumitrescu, Dinusha P Karunaratne, S V Babu, Kenneth N Wallace, Silvana Andreescu
Chemical mechanical planarization (CMP) is a widely used technique for the manufacturing of integrated circuit chips in the semiconductor industry. The process generates large amounts of waste containing engineered particles, chemical additives, and chemo-mechanically removed compounds. The environmental and health effects associated with the release of CMP materials are largely unknown and have recently become of significant concern. Using a zebrafish embryo assay, we established toxicity profiles of individual CMP particle abrasives (SiO2 and CeO2), chemical additives (hydrogen peroxide, proline, glycine, nicotinic acid, and benzotriazole), as well as three model representative slurries and their resulting waste...
October 27, 2017: Chemosphere
https://www.readbyqxmd.com/read/29062152/nematicidal-effects-of-5-aminolevulinic-acid-on-plant-parasitic-nematodes
#8
Feixue Cheng, Jian Wang, Zhiqiang Song, Ju'e Cheng, Deyong Zhang, Yong Liu
Plant-parasitic nematodes are important agricultural pests and often cause serious crop losses. Novel, environmental friendly nematicides are urgently needed because of the harmful effects of some existing nematicides on human health. 5-Aminolevulinic acid (ALA) was reported as a potential biodegradable herbicide, insecticide, or plant-growth promoting agent. Lack of information on ALA against plant-parasitic nematodes prompted this investigation to determine the effects of ALA on Meloidogyne incognita, Heterodera glycines, Pratylenchus coffeae, and Bursaphelenchus xylophilus...
September 2017: Journal of Nematology
https://www.readbyqxmd.com/read/29032784/spent-culture-medium-analysis-from-individually-cultured-bovine-embryos-demonstrates-metabolomic-differences
#9
Kayla J Perkel, Pavneesh Madan
Spent culture medium can provide valuable information regarding the physiological state of a bovine preimplantation embryos through non-invasive analysis of the sum/depleted metabolite constituents. Metabolomics has become of great interest as an adjunct technique to morphological and cleavage-rate assessment, but more importantly, in improving our understanding of metabolism. In this study, in vitro produced bovine embryos developing at different rates were evaluated using proton nuclear magnetic resonance (1H NMR)...
October 16, 2017: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/28946319/a-major-daidzin-metabolite-7-8-4-trihydroxyisoflavone-found-in-the-plasma-of-soybean-extract-fed-rats-attenuates-monocyte-endothelial-cell-adhesion
#10
Charles C Lee, Stéphanie Dudonné, Jong Hun Kim, Ji Seung Kim, Pascal Dubé, Jong-Eun Kim, Yves Desjardins, Jung Han Yoon Park, Ki Won Lee, Chang Yong Lee
Among many functional foods and their phytochemicals, ingestion of soybean (Glycine max) is highly correlated to reduced risk of cardiovascular diseases. Validation of potential health benefits of functional foods requires information about the bioavailability and metabolism of bioactive compounds. In this context, several phase I and II metabolites of isoflavones were target-analyzed in the plasma of rats acutely supplemented with soybean embryo extract. A daidzein metabolite, 7,8,4'-trihydroxyisoflavone (7,8,4'-THI), was found to have the highest average area under curve value (574...
February 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28934858/metabolism-nutrition-and-redox-signaling-of-hydroxyproline
#11
Zhenlong Wu, Yongqing Hou, Zhaolai Dai, Chien-An Hu, Guoyao Wu
SIGNIFICANCE: Hydroxyproline is a structurally and physiologically important imino acid in animals. It is provided from diets and endogenous synthesis, and its conversion into glycine is enhances the production of glutathione, DNA, heme, and protein. Furthermore, oxidation of hydroxyproline by hydroxyproline oxidase plays an important role in cell antioxidative reactions, survival, and homeostasis. Understanding the mechanisms whereby hydroxyproline participates in metabolism and cell signaling can improve the nutrition and health of animals and humans...
September 21, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28931688/a-selective-bottleneck-shapes-the-evolutionary-mutant-spectra-of-enterovirus-a71-during-viral-dissemination-in-humans
#12
Sheng-Wen Huang, Yi-Hui Huang, Huey-Pin Tsai, Pin-Hwa Kuo, Shih-Min Wang, Ching-Chuan Liu, Jen-Ren Wang
RNA viruses accumulate mutations to rapidly adapt to environmental changes. Enterovirus A71 (EV-A71) causes various clinical manifestations with occasional severe neurological complications. However, the mechanism by which EV-A71 evolves within the human body is unclear. Utilizing deep sequencing and haplotype analyses of viruses from various tissues of an autopsy patient, we sought to define the evolutionary pathway by which enterovirus A71 evolves fitness for invading the central nervous system in humans...
December 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28876062/modulation-of-glycine-mediated-spinal-neurotransmission-for-the-treatment-of-chronic-pain
#13
Christopher L Cioffi
Chronic pain constitutes a significant and expanding worldwide health crisis. Currently available analgesics poorly serve individuals suffering from chronic pain, and new therapeutic agents that are more effective, safer, and devoid of abuse liabilities are desperately needed. Among the myriad of cellular and molecular processes contributing to chronic pain, spinal disinhibition of pain signaling to higher cortical centers plays a critical role. Accumulating evidence shows that glycinergic inhibitory neurotransmission in the spinal cord dorsal horn gates nociceptive signaling, is essential in maintaining physiological pain sensitivity, and is diminished in pathological pain states...
September 22, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28868128/design-of-peptides-interfering-with-iron-dependent-regulator-ider-and-evaluation-of-mycobacterium-tuberculosis-growth-inhibition
#14
Himen Salimizand, Saeid Amel Jamehdar, Leila Babaei Nik, Hamid Sadeghian
OBJECTIVES: Tuberculosis (TB), a disease caused by Mycobacterium tuberculosis (Mtb), stayed a global health thread with high mortality rate. Since TB has a long-term treatment, it leads high risk of drug resistant development, and there is an urgent to find new drugs. The aim of this study was designing new inhibitors for a new drug target, iron dependent regulator, IdeR. MATERIALS AND METHODS: Based on the interaction most populated amino acids of IdeR to the related gene operators, 50 short peptides were modeled...
June 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28861066/unraveling-the-fecal-microbiota-and-metagenomic-functional-capacity-associated-with-feed-efficiency-in-pigs
#15
Hui Yang, Xiaochang Huang, Shaoming Fang, Maozhang He, Yuanzhang Zhao, Zhenfang Wu, Ming Yang, Zhiyan Zhang, Congying Chen, Lusheng Huang
Gut microbiota plays fundamental roles in energy harvest, nutrient digestion, and intestinal health, especially in processing indigestible components of polysaccharides in diet. Unraveling the microbial taxa and functional capacity of gut microbiome associated with feed efficiency can provide important knowledge to improve pig feed efficiency in swine industry. In the current research, we studied the association of fecal microbiota with feed efficiency in 280 commercial Duroc pigs. All experimental pigs could be clustered into two enterotype-like groups...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28766269/analysis-of-neurotoxic-amino-acids-from-marine-waters-microbial-mats-and-seafood-destined-for-human-consumption-in-the-arabian-gulf
#16
Aspassia D Chatziefthimiou, Eric J Deitch, William B Glover, James T Powell, Sandra Anne Banack, Renee A Richer, Paul A Cox, James S Metcalf
Human health risks associated with exposure to algal and cyanobacterial toxins (phycotoxins) have been largely concerned with aquatic habitats. People inhabiting desert environments may be exposed to phycotoxins present in terrestrial environments, where cyanobacterial crusts dominate. Seafood comprises a significant portion of the human diet in desert environments proximal to an ocean or sea. Consequently, in addition to terrestrial exposure to cyanotoxins, the potential exists that seafood may be an important exposure route for cyanotoxins in desert regions...
August 1, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28737704/toxicity-at-the-edge-of-life-a-review-on-cyanobacterial-toxins-from-extreme-environments
#17
REVIEW
Samuel Cirés, María Cristina Casero, Antonio Quesada
Cyanotoxins are secondary metabolites produced by cyanobacteria, of varied chemical nature and toxic effects. Although cyanobacteria thrive in all kinds of ecosystems on Earth even under very harsh conditions, current knowledge on cyanotoxin distribution is almost restricted to freshwaters from temperate latitudes. In this review, we bring to the forefront the presence of cyanotoxins in extreme environments. Cyanotoxins have been reported especially in polar deserts (both from the Arctic and Antarctica) and alkaline lakes, but also in hot deserts, hypersaline environments, and hot springs...
July 24, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28691491/peptidoglycan-cross-linking-preferences-of-staphylococcus-aureus-penicillin-binding-proteins-have-implications-for-treating-mrsa-infections
#18
Veerasak Srisuknimit, Yuan Qiao, Kaitlin Schaefer, Daniel Kahne, Suzanne Walker
Methicillin-resistant Staphylococcus aureus (MRSA) infections are a global public health problem. MRSA strains have acquired a non-native penicillin-binding protein called PBP2a that cross-links peptidoglycan when the native S. aureus PBPs are inhibited by β-lactams. It has been proposed that the native S. aureus PBPs can use cell wall precursors having different glycine branch lengths (penta-, tri-, or monoglycine), while PBP2a can only cross-link peptidoglycan strands bearing a complete pentaglycine branch...
July 26, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28666225/hplc-ms-ms-targeted-metabolic-profiling-reveals-distinct-metabolic-profiles-from-staphylococcus-aureus-small-colony-variants
#19
Chen Wang, Jiangjiang Zhu
Staphylococcus aureus is a world-wide health threat due to its prevalence and possible resistance to antibiotic treatment. A variety reasons can contribute to S. aureus antibiotic resistance and one group of phenotypes that may be discovered from S. aureus is named small-colony variants (SCVs). This study focused on applying a HPLC-MS/MS based targeted metabolic profiling approach to detect a set of metabolites that are dysregulated during S. aureus SCVs formation. Over one hundred and eighty metabolites were confidently detected and their difference between S...
August 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28653198/a-combined-nmr-and-hplc-ms-ms-based-metabolomics-to-evaluate-the-metabolic-perturbations-and-subacute-toxic-effects-of-endosulfan-on-mice
#20
Ping Zhang, Wentao Zhu, Dezhen Wang, Jin Yan, Yao Wang, Zhiqiang Zhou, Lin He
Endosulfan is the newly persistent organic pollutants (POPs) added to the Stockholm Convention as its widespread use, persistence, bioaccumulation, long-range transport, endocrine disruption, and toxicity related to various adverse effects. In the present study, male mice were administrated endosulfan at 0, 0.5, and 3.5 mg/kg by gavage for 2 weeks. (1)H-NMR-based urinary metabolomics, HPLC-MS/MS-based targeted serum metabolomics, clinical analysis, and histopathology techniques were employed to evaluate the metabolic perturbations of subacute endosulfan exposure...
June 26, 2017: Environmental Science and Pollution Research International
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