keyword
https://read.qxmd.com/read/38514519/longitudinal-aortic-strain-ventriculo-arterial-coupling-and-fatty-acid-oxidation-novel-insights-into-human-cardiovascular-aging
#1
JOURNAL ARTICLE
Hongzhou Zhang, Shuang Leng, Fei Gao, Jean-Paul Kovalik, Ru-San Tan, Hai Ning Wee, Kee Voon Chua, Jianhong Ching, Xiaodan Zhao, John Allen, Qinghua Wu, Tim Leiner, Liang Zhong, Angela S Koh
Aging-induced aortic stiffness has been associated with altered fatty acid metabolism. We studied aortic stiffness using cardiac magnetic resonance (CMR)-assessed ventriculo-arterial coupling (VAC) and novel aortic (AO) global longitudinal strain (GLS) combined with targeted metabolomic profiling. Among community older adults without cardiovascular disease, VAC was calculated as aortic pulse wave velocity (PWV), a marker of arterial stiffness, divided by left ventricular (LV) GLS. AOGLS was the maximum absolute strain measured by tracking the phasic distance between brachiocephalic artery origin and aortic annulus...
March 22, 2024: GeroScience
https://read.qxmd.com/read/38428742/effect-of-1-year-lifestyle-intervention-with-energy-reduced-mediterranean-diet-and-physical-activity-promotion-on-the-gut-metabolome-and-microbiota-a-randomized-clinical-trial
#2
JOURNAL ARTICLE
Jesús F García-Gavilán, Alessandro Atzeni, Nancy Babio, Liming Liang, Clara Belzer, Jesús Vioque, Dolores Corella, Montserrat Fitó, Josep Vidal, Isabel Moreno-Indias, Laura Torres-Collado, Oscar Coltell, Estefanía Toledo, Clary Clish, Javier Hernando, Huan Yun, Adrián Hernández-Cacho, Sarah Jeanfavre, Courtney Dennis, Ana M Gómez-Pérez, Maria Angeles Martínez, Miguel Ruiz Canela, Francisco J Tinahones, Frank B Hu, Jordi Salas-Salvadó
BACKGROUND: The health benefits of the Mediterranean diet (MedDiet) have been linked to the presence of beneficial gut microbes and related metabolites. However, its impact on the fecal metabolome remains poorly understood. OBJECTIVE: Our goal was to investigate the weight loss effects of a 1-year lifestyle intervention based on an energy-reduced MedDiet coupled with physical activity (intervention group), compared to an ad libitum MedDiet (control group), on fecal metabolites, fecal microbiota, and their potential association with cardiovascular risk factors METHODS: A total of 400 participants (200 from each study group), aged 55-75 years, and at high cardiovascular risk, were included...
February 28, 2024: American Journal of Clinical Nutrition
https://read.qxmd.com/read/38337445/lifestyle-and-lipoprotein-a-levels-does-a-specific-counseling-make-sense
#3
REVIEW
Federica Fogacci, Valentina Di Micoli, Pierre Sabouret, Marina Giovannini, Arrigo F G Cicero
Lipoprotein(Lp)(a) is a variant of low-density lipoprotein (LDL), bound to apolipoprotein B100, whose levels are associated with a significant increase in the risk of atherosclerosis-related cardiovascular events, but also to aortic stenosis and atrial fibrillation. Since plasma levels of Lp(a) are commonly considered resistant to lifestyle changes, we critically reviewed the available evidence on the effect of weight loss, dietary supplements, and physical activity on this risk factor. In our review, we observed that relevant body weight loss, a relatively high intake of saturated fatty acids, the consumption of red wine, and intense physical exercise seems to be associated with significantly lower plasma Lp(a) levels...
January 28, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38181846/aldehyde-dehydrogenase-2-serves-as-a-key-cardiometabolic-adaptation-regulator-in-response-to-plateau-hypoxia-in-mice
#4
JOURNAL ARTICLE
Rifeng Gao, Kun Yang, Shiguan Le, Hanchuan Chen, Xiaolei Sun, Zhen Dong, Pingjin Gao, Xilu Wang, Jiaran Shi, Yanan Qu, Xiang Wei, Kai Hu, Jiucun Wang, Li Jin, Yi Li, Junbo Ge, Aijun Sun
High-altitude heart disease (HAHD) is a complex pathophysiological condition related to systemic hypobaric hypoxia in response to transitioning to high altitude. Hypoxia can cause myocardial metabolic dysregulation, leading to an increased risk of heart failure and sudden cardiac death. Aldehyde dehydrogenase 2 (ALDH2) could regulate myocardial energy metabolism and plays a protective role in various cardiovascular diseases. This study aims to determine the effects of plateau hypoxia (PH) on cardiac metabolism and function, investigate the associated role of ALDH2, and explore potential therapeutic targets...
January 3, 2024: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/38174696/omics-signatures-linking-persistent-organic-pollutants-to-cardiovascular-disease-in-the-swedish-mammography-cohort
#5
JOURNAL ARTICLE
Tessa Schillemans, Yingxiao Yan, Anton Ribbenstedt, Carolina Donat-Vargas, Christian H Lindh, Hannu Kiviranta, Panu Rantakokko, Alicja Wolk, Rikard Landberg, Agneta Åkesson, Carl Brunius
Cardiovascular disease (CVD) development may be linked to persistent organic pollutants (POPs), including organochlorine compounds (OCs) and perfluoroalkyl and polyfluoroalkyl substances (PFAS). To explore underlying mechanisms, we investigated metabolites, proteins, and genes linking POPs with CVD risk. We used data from a nested case-control study on myocardial infarction (MI) and stroke from the Swedish Mammography Cohort - Clinical ( n = 657 subjects). OCs, PFAS, and multiomics (9511 liquid chromatography-mass spectrometry (LC-MS) metabolite features; 248 proteins; 8110 gene variants) were measured in baseline plasma...
January 4, 2024: Environmental Science & Technology
https://read.qxmd.com/read/38110181/metabolomic-insights-on-potassium-excretion-blood-pressure-and-glucose-homeostasis-the-african-predict-study
#6
JOURNAL ARTICLE
Michél Strauss-Kruger, Marlien Pieters, Tertia van Zyl, Lebo F Gafane-Matemane, Gontse G Mokwatsi, Adriaan Jacobs, Aletta E Schutte, Roan Louw, Catharina Mc Mels
BACKGROUND: Low-potassium intake is associated with a higher risk of type 2 diabetes and hypertension. Both conditions occur more frequently in Black populations, who also consume less potassium-rich foods. OBJECTIVES: Using metabolomics to identify dysregulated metabolic pathways associated with low-potassium excretion may procure more accurate entry points for nutritional prevention and intervention for type 2 diabetes and hypertension. METHODS: A total of 440 White and 350 Black adults from the African-PREDICT study (aged 20-30 y) were included...
February 2024: Journal of Nutrition
https://read.qxmd.com/read/38101999/the-effects-of-l-carnitine-supplementation-on-blood-pressure-in-adults-a-systematic-review-and-dose-response-meta-analysis
#7
REVIEW
Shiva Rahimipour Anaraki, Yasaman Aali, Mahlagha Nikbaf-Shandiz, Niloufar Rasaei, Alireza Khadem, Hossein Bahari, Zeinab Khalse, Samira Rastgoo, Farideh Shiraseb, Omid Asbaghi
PURPOSE: Hypertension stands as a prominent risk factor for cardiovascular disease, making it of utmost importance to address. Studies have shown that L-carnitine supplementation may lower blood pressure (BP) parameters in different populations. Therefore, we have conducted a systematic review and dose-response meta-analysis of published Randomized Controlled Trials (RCTs), including the most recent articles on the effect of L-carnitine supplementation on BP. METHODS: PubMed, ISI Web of Science, Cochrane databases, and Scopus were used to collect RCT studies published up to October 2022 without limitations in language...
December 14, 2023: Clinical Therapeutics
https://read.qxmd.com/read/38034195/cardiovascular-event-predictors-in-hospitalized-chronic-kidney-disease-ckd-patients-a-nationwide-inpatient-sample-analysis
#8
JOURNAL ARTICLE
Fidelis Uwumiro, Chikodili Nebuwa, Chimaobi O Nwevo, Victory Okpujie, Osasumwen Osemwota, Emeka S Obi, Omamuyovbi Nwoagbe, Ejiroghene Tejere, Joycelyn Adjei-Mensah, Charles T Ogbodo, Christopher N Ekeh
INTRODUCTION: This study seeks to confirm the risk factors linked to cardiovascular (CV) events in chronic kidney disease (CKD), which have been identified as CKD-related. We aim to achieve this using a larger, more diverse, and nationally representative dataset, contrasting with previous research conducted on smaller patient cohorts. METHODS:  The study utilized the nationwide inpatient sample database to identify adult hospitalizations for CKD from 2016 to 2020, employing validated ICD-10-CM/PCS codes...
October 2023: Curēus
https://read.qxmd.com/read/37958793/genetic-and-lifestyle-related-factors-influencing-serum-hyper-propionylcarnitine-concentrations-and-their-association-with-metabolic-syndrome-and-cardiovascular-disease-risk
#9
JOURNAL ARTICLE
Yong-Hwa Lee, Sunmin Park
The genetic and environmental determinants of serum propionylcarnitine concentrations (PC) remain largely unexplored. This study investigated the impact of genetic and environmental factors on serum propionylcarnitine levels in middle-aged and elderly participants from the Ansan/Ansung cohort of the Korean Genome and Epidemiology Study. Our goal was to understand the role of PC on the risk of metabolic syndrome (MetS) leading to cardiovascular disease, particularly concerning branched-chain amino acid (BCAA) metabolism...
October 31, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37850287/-the-role-of-antioxidants-in-the-therapy-of-metabolic-syndrome-in-men
#10
JOURNAL ARTICLE
N A Nashivochnikova, V N Krupin, V E Leanovich
INTRODUCTION: Metabolic syndrome (MetS) is a combination of hormonal, metabolic and clinical disorders. Currently, MetS in men is considered as one of the main risk factors for the development of cardiovascular diseases, insulin resistance, and pathology of the reproductive system. AIM: To study the effect of a complex of folic acid, L-carnitine, vitamin E, zinc and selenium, which are part of the biologically active food supplement "Speroton", on the parameters of carbohydrate and lipid metabolism in men with MetS, especially in the early stages of its development, as well as on erectile function and quality of life of patients...
September 2023: Urologii︠a︡
https://read.qxmd.com/read/37574027/short-and-medium-chain-acylcarnitines-as-markers-of-outcome-in-diabetic-and-non-diabetic-subjects-with-acute-coronary-syndromes
#11
JOURNAL ARTICLE
Allan Davies, Florian A Wenzl, Xinmin S Li, Patric Winzap, Slayman Obeid, Roland Klingenberg, François Mach, Lorenz Räber, Olivier Muller, Christian M Matter, Reijo Laaksonen, Zeneng Wang, Stanley L Hazen, Thomas F Lüscher
BACKGROUND: Carnitine metabolism produces numerous molecular species of short-, medium-, and long-chain acylcarnitines, which play important roles in energy homeostasis and fatty acid transport in the myocardium. Given that disturbances in the carnitine metabolism are linked to cardiometabolic disease, we studied the relationship of circulating acylcarnitines with outcomes in patients with acute coronary syndromes (ACS) and evaluated differences in circulating levels of these metabolites between diabetic and non-diabetic patients...
October 15, 2023: International Journal of Cardiology
https://read.qxmd.com/read/37501168/metabolic-systems-approaches-update-molecular-insights-of-clinical-phenotypes-and-cardiovascular-risk-in-patients-with-homozygous-familial-hypercholesterolemia
#12
JOURNAL ARTICLE
Zhiyong Du, Fan Li, Long Jiang, Linyi Li, Yunhui Du, Huahui Yu, Yan Luo, Yu Wang, Haili Sun, Chaowei Hu, Jianping Li, Ya Yang, Xiaolu Jiao, Luya Wang, Yanwen Qin
BACKGROUND: Homozygous familial hypercholesterolemia (HoFH) is an orphan metabolic disease characterized by extremely elevated low-density lipoprotein cholesterol (LDL-C), xanthomas, aortic stenosis, and premature atherosclerotic cardiovascular disease (ASCVD). In addition to LDL-C, studies in experimental models and small clinical populations have suggested that other types of metabolic molecules might also be risk factors responsible for cardiovascular complications in HoFH, but definitive evidence from large-scale human studies is still lacking...
July 27, 2023: BMC Medicine
https://read.qxmd.com/read/37463653/importance-of-gut-microbiota-metabolites-in-the-development-of-cardiovascular-diseases-cvd
#13
REVIEW
Maryam Hemmati, Setayesh Kashanipoor, Payman Mazaheri, Farnaz Alibabaei, Ali Babaeizad, Shima Asli, Sina Mohammadi, Amir Hosein Gorgin, Kamran Ghods, Bahman Yousefi, Majid Eslami
Cardiovascular disease (CVD) remains the most common cause of death worldwide and has become a public health concern. The proven notable risk factors for CVD are atherosclerosis, hypertension, diabetes, dyslipidemia, inflammation, and some genetic defects. However, research has shown a correlation between metabolic health, gut microbiota, and dietary risk factors. The gut microbiota makes an important contribution to human functional metabolic pathways by contributing enzymes that are not encoded by the human genome, for instance, the breakdown of polysaccharides, polyphenols and vitamins synthesis...
September 15, 2023: Life Sciences
https://read.qxmd.com/read/37448910/effect-of-exogenous-l-carnitine-on-aortic-stiffness-in-dyslipidemic-adolescents-design-of-a-quadruple-blind-randomized-controlled-interventional-trial
#14
JOURNAL ARTICLE
Justin P Zachariah, Sandra Pena, Philip J Lupo, Nagireddy Putluri, Daniel J Penny, Melissa A Richard
BACKGROUND: Atherosclerotic cardiovascular disease (ASCVD) risk factors including vascular remodeling leading to hypertension and dyslipidemia are prevalent among children and adolescents. Conflicting observational and Mendelian randomization data suggest endogenous carnitine may affect arterial stiffness and lipid traits. Because of this, we developed a study to evaluate the causal role for carnitine in arterial stiffness at a point when the lifecourse trajectory to hypertension can be modified...
August 2023: Contemporary Clinical Trials Communications
https://read.qxmd.com/read/37369514/targeting-skeletal-muscle-dysfunction-with-l-carnitine-for-the-treatment-of-patients-with-chronic-obstructive-pulmonary-disease
#15
REVIEW
Ba X Hoang, B O Han, William H Fang, Anh K Nguyen, David G Shaw, Cuong Hoang, Hau D Tran
Chronic obstructive pulmonary disease (COPD) is a major medical problem and the world's third leading cause of death. COPD is a chronic disease with heterogeneous clinical symptoms, disease progression, and treatment responses. Besides pulmonary symptomatology, the common systemic clinical manifestations are cachexia, muscle weakness, and widespread comorbidities such as cardiovascular diseases, diabetes, osteoporosis, and infections. The adverse effects of pharmaceutical therapies contribute to the difficulty of health risk assessment and management of COPD patients...
2023: In Vivo
https://read.qxmd.com/read/37175227/trimethylamine-n-oxide-tmao-inducing-endothelial-injury-uplc-ms-ms-based-quantification-and-the-activation-of-cathepsin-b-mediated-nlrp3-inflammasome
#16
JOURNAL ARTICLE
Dongyu Lei, Wenbo Yu, Yi Liu, Yujie Jiang, Xiaohui Li, Jing Lv, Ying Li
TMAO is a new risk biomarker for cardiovascular disease. With trimethylammonium as its main chemical skeleton, TMAO is structurally similar to many endogenous metabolites, such as acetylcholine, carnitine, phosphorylcholine, etc. The mechanism of TMAO on the pathological process of CVD is still unclear. In this study, the quantitative analysis of plasma TMAO is conducted, and the contribution of Cathepsin B and NLRP3 inflammasome during the process of TMAO-induced endothelial injury was proposed and investigated at animal and cellular levels...
April 29, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37164358/association-of-healthy-dietary-patterns-and-cardiorespiratory-fitness-in-the-community
#17
JOURNAL ARTICLE
Michael Y Mi, Priya Gajjar, Maura E Walker, Patricia Miller, Vanessa Xanthakis, Venkatesh L Murthy, Martin G Larson, Ramachandran S Vasan, Ravi V Shah, Gregory D Lewis, Matthew Nayor
AIMS: To evaluate the associations of dietary indices and quantitative cardiorespiratory fitness (CRF) measures in a large, community-based sample harnessing metabolomic profiling to interrogate shared biology. METHODS AND RESULTS: Framingham Heart Study (FHS) participants underwent maximum effort cardiopulmonary exercise tests for CRF quantification (via peak VO2) and completed semi-quantitative food frequency questionnaires. Dietary quality was assessed by the Alternative Healthy Eating Index (AHEI) and Mediterranean-style Diet Score (MDS), and fasting blood concentrations of 201 metabolites were quantified...
October 10, 2023: European Journal of Preventive Cardiology
https://read.qxmd.com/read/37022264/probio-x-relieves-symptoms-of-hyperlipidemia-by-regulating-patients-gut-microbiome-blood-lipid-metabolism-and-lifestyle-habits
#18
JOURNAL ARTICLE
Huan Wang, Cuicui Ma, Yan Li, Lei Zhang, Lima A, Chengcong Yang, Feiyan Zhao, Haifeng Han, Dongyang Shang, Fan Yang, Yuying Zhang, Heping Zhang, Zhihong Sun, Ruifang Guo
Hyperlipidemia is a key risk factor for cardiovascular disease, and it is associated with lipid metabolic disorders and gut microbiota dysbiosis. Here, we aimed to investigate the beneficial effects of 3-month intake of a mixed probiotic formulation in hyperlipidemic patients ( n  = 27 and 29 in placebo and probiotic groups, respectively). The blood lipid indexes, lipid metabolome, and fecal microbiome before and after the intervention were monitored. Our results showed that probiotic intervention could significantly decrease the serum levels of total cholesterol, triglyceride, and low-density lipoprotein cholesterol ( P <  0...
April 6, 2023: Microbiology Spectrum
https://read.qxmd.com/read/36883587/trimethylamine-n-oxide-is-associated-with-long-term-mortality-risk-the-multi-ethnic-study-of-atherosclerosis
#19
JOURNAL ARTICLE
Meng Wang, Xinmin S Li, Zeneng Wang, Marcia C de Oliveira Otto, Rozenn N Lemaitre, Amanda Fretts, Nona Sotoodehnia, Matthew Budoff, Ina Nemet, Joseph A DiDonato, Wai Hong Wilson Tang, Bruce M Psaty, David S Siscovick, Stanley L Hazen, Dariush Mozaffarian
AIMS: Little is known about associations of trimethylamine N-oxide (TMAO), a novel gut microbiota-generated metabolite of dietary phosphatidylcholine and carnitine, and its changes over time with all-cause and cause-specific mortality in the general population or in different race/ethnicity groups. The study aimed to investigate associations of serially measured plasma TMAO levels and changes in TMAO over time with all-cause and cause-specific mortality in a multi-ethnic community-based cohort...
March 8, 2023: European Heart Journal
https://read.qxmd.com/read/36844729/dietary-precursors-and-cardiovascular-disease-a-mendelian-randomization-study
#20
JOURNAL ARTICLE
Wangwei Jing, Shushi Huang, Pingping Xiang, Jiniu Huang, Hong Yu
BACKGROUND: The Dietary precursor has been identified as a contributor in the development of cardiovascular disease. However, it is inconsistent if dietary precursors could affect the process of cardiovascular disease. METHODS: Here we performed Mendelian randomization (MR) analysis of the data from genome-wide association study of European ancestry to evaluate the independent effects of three dietary precursors on cardiovascular disease (CVD), myocardial infarction (MI), heart failure (HF), atrial fibrillation (AF), and valvular disease (VHD)...
2023: Frontiers in Cardiovascular Medicine
keyword
keyword
81302
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.