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https://www.readbyqxmd.com/read/28062866/-bovine-lactoferrin-decreases-the-invasion-of-salmonella-enterica-to-hep-2-cells
#1
Liz J Barreto Arce, Carmen A Contreras García, David Durand Vara, Theresa Ochoa Woodell
OBJECTIVE: To assess the effect of bovine lactoferrin (bLf) on the invasion of Salmonella enterica ser. Typhimurium to HEp-2 cells. MATERIALS AND METHODS: HEp-2 monolayers were infected with 106 colony forming unit (CFU) of bacteria in the absence and presence of 1 and 10 mg/mL of bLf (iron-saturated) and incubated 1.5 hours at 37°C. Two treatments were evaluated: pre- infection (HEp-2 cells were incubated with bLf one hour prior to infection with Salmonella) and post-infection (bLf was added 15 minutes after the infection)...
October 2016: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28062286/qseb-mediates-biofilm-formation-and-invasion-in-salmonella-enterica-serovar-typhi
#2
Ying Ji, Wenliang Li, Ying Zhang, Long Chen, Yiquan Zhang, Xueming Zheng, Xinxiang Huang, Bin Ni
QseB is a response regulator of the QseBC two-component system (TCS) which is associated with quorum sensing and functions as a global regulator of flagella, biofilm formation, and virulence. The function of QseB and its interaction with QseC has been the subject of study in some organisms, however, little work was done in Salmonella enterica serovar Typhi (S. Typhi). The objective of this study was to investigate the effect of QseB on biofilm formation and virulence in S. Typhi. It showed that the biofilm formation ability of qseC mutant was limited as compared to the wild type strain...
January 3, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28062009/reduced-particle-size-wheat-bran-is-butyrogenic-and-lowers-salmonella-colonization-when-added-to-poultry-feed
#3
K Vermeulen, J Verspreet, C M Courtin, F Haesebrouck, R Ducatelle, F Van Immerseel
Feed additives, including prebiotics, are commonly used alternatives to antimicrobial growth promoters to improve gut health and performance in broilers. Wheat bran is a highly concentrated source of (in)soluble fiber which is partly degraded by the gut microbiota. The aim of the present study was to investigate the potential of wheat bran as such to reduce colonization of the cecum and shedding of Salmonella bacteria in vivo. Also, the effect of particle size was evaluated. Bran with an average reduced particle size of 280μm decreased levels of cecal Salmonella colonization and shedding shortly after infection when compared to control groups and groups receiving bran with larger particle sizes...
January 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28056035/a-systematic-review-of-the-incidence-risk-factors-and-case-fatality-rates-of-invasive-nontyphoidal-salmonella-ints-disease-in-africa-1966-to-2014
#4
Ifeanyi Valentine Uche, Calman A MacLennan, Allan Saul
This study systematically reviews the literature on the occurrence, incidence and case fatality rate (CFR) of invasive nontyphoidal Salmonella (iNTS) disease in Africa from 1966 to 2014. Data on the burden of iNTS disease in Africa are sparse and generally have not been aggregated, making it difficult to describe the epidemiology that is needed to inform the development and implementation of effective prevention and control policies. This study involved a comprehensive search of PubMed and Embase databases...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28039133/dynamics-of-salmonella-shedding-and-welfare-of-hens-in-free-range-egg-production-systems
#5
V C Gole, R Woodhouse, C Caraguel, T Moyle, J-L Rault, M Sexton, K Chousalkar
: The current study investigated the effect of environmental stressors (weather changes) on Salmonella shedding in free range production systems, and correlations with behavioural and physiological measures (faecal glucocorticoid metabolites). This involved longitudinal and point in time surveys of Salmonella shedding and environmental contamination on four commercial free range layer farms. The shedding of Salmonella was variable across free range farms and in different seasons. There were no significant effects of season on the Salmonella prevalence during this investigation...
December 30, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28028851/review-on-the-effects-of-potential-prebiotics-on-controlling-intestinal-enteropathogens-salmonella-and-escherichia%C3%A2-coli-in-pig-production
#6
REVIEW
T H T Tran, N Everaert, J Bindelle
Salmonella enterica serotypes (Salmonella sp.) are the second cause of bacterial foodborne zoonoses in humans after campylobacteriosis. Pork is the third most important cause for outbreak-associated salmonellosis, and colibacillosis is the most important disease in piglets and swine. Attachment to host cells, translocation of effector proteins into host cells, invasion and replication in tissues are the vital virulence steps of these pathogens that help them to thrive in the intestinal environment and invade tissues...
December 27, 2016: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/27998639/characterization-of-o-antigen-delivered-by-generalized-modules-for-membrane-antigens-gmma-vaccine-candidates-against-nontyphoidal-salmonella
#7
G De Benedetto, R Alfini, P Cescutti, M Caboni, L Lanzilao, F Necchi, A Saul, C A MacLennan, S Rondini, F Micoli
Invasive nontyphoidal Salmonella disease (iNTS) is a leading cause of death and morbidity in Africa. The most common pathogens are Salmonella enterica serovars Typhimurium and Enteritidis. The O-antigen portion of their lipopolysaccharide is a target of protective immunity and vaccines targeting O-antigen are currently in development. Here we investigate the use of Generalized Modules for Membrane Antigens (GMMA) as delivery system for S. Typhimurium and S. Enteritidis O-antigen. Gram-negative bacteria naturally shed outer membrane in a blebbing process...
January 11, 2017: Vaccine
https://www.readbyqxmd.com/read/27997726/functional-relatedness-in-the-inv-mxi-spa-type-iii-secretion-system-family
#8
Jessica A Klein, Biren M Dave, Amogelang R Raphenya, Andrew G McArthur, Leigh A Knodler
Type III Secretion Systems (T3SSs) are structurally conserved nanomachines that span the inner and outer bacterial membranes, and via a protruding needle complex contact host cell membranes and deliver type III effector proteins. T3SS are phylogenetically divided into several families based on structural basal body components. Here we have studied the evolutionary and functional conservation of four T3SS proteins from the Inv/Mxi-Spa family: a cytosolic chaperone, two hydrophobic translocators that form a plasma membrane-integral pore, and the hydrophilic "tip complex" translocator that connects the T3SS needle to the translocon pore...
December 20, 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/27982698/salmonella-enterica-serotype-napoli-is-the-first-cause-of-invasive-nontyphoidal-salmonellosis-in-lombardy-italy-2010-2014-and-belongs-to-typhi-subclade
#9
Pol Huedo, Maria Gori, Anna Zolin, Ettore Amato, Giulia Ciceri, Anna Bossi, Mirella Pontello
Salmonella enterica serotype Napoli (S. Napoli) is currently emerging in Europe and particularly in Italy, where in 2014 it caused a large outbreak associated with elevated rates of bacteremia. However, no study has yet investigated its invasive ability and phylogenetic classification. Here, we show that between 2010 and 2014, S. Napoli was the first cause of invasive salmonellosis affecting 40 cases out of 687 (invasive index: 5.8%), which is significantly higher than the invasive index of all the other nontyphoidal serotypes (2...
December 16, 2016: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/27964724/antimicrobial-resistance-pattern-a-report-of-microbiological-cultures-at-a-tertiary-hospital-in-tanzania
#10
Nyambura Moremi, Heike Claus, Stephen E Mshana
BACKGROUND: Antimicrobial resistance has been declared by the World Health Organization as a threat to the public health. The aim of this study was to analyze antimicrobial resistance patterns of the common pathogens occurring at the Bugando Medical Centre (BMC), Mwanza, Tanzania to provide data for antimicrobial stewardship programmes. METHODS: A total of 3330 microbiological culture results scripts representing non-repetitive specimens reported between June 2013 and May 2015 were retrieved and analyzed for pathogens and their susceptibility patterns using STATA-11 software...
December 13, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27951516/salmosan-a-%C3%AE-galactomannan-rich-product-in-combination-with-lactobacillus-plantarum-contributes-to-restore-intestinal-epithelial-barrier-function-by-modulation-of-cytokine-production
#11
M Teresa Brufau, Joan Campo-Sabariz, Sergi Carné, Ruth Ferrer, Raquel Martín-Venegas
Mannan-oligosaccharides (MOSs) are mannose-rich substrates with several intestinal health-promoting properties. The aim of this study was to investigate the potential capacity of Salmosan (S-βGM), a β-galactomannan-rich MOS product, to restore epithelial barrier function independently from its capacity to reduce bacterial invasion. In addition, the combination of S-βGM with the proven probiotic Lactobacillus plantarum (LP) was also tested. Paracellular permeability was assessed by transepithelial electrical resistance (TER) in co-cultures of Caco-2 cells and macrophages (differentiated from THP-1 cells) stimulated with LPS of Salmonella Enteritidis and in Caco-2 cell cultures stimulated with TNF-α in the absence or presence of 500 μg/ml S-βGM, LP (MOI 10) or a combination of both...
November 23, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27943051/effect-of-lactobacillus-plantarum-tennozu-su2-on-salmonella-typhimurium-infection-in-human-enterocyte-like-ht-29-luc-cells-and-balb-c-mice
#12
Shino Hirano, Yasushi Yokota, Mika Eda, Takashi Kuda, Ayane Shikano, Hajime Takahashi, Bon Kimura
The probiotic properties and inhibitory effect on Salmonella Typhimurium adhesion on human enterocyte-like HT-29-Luc cells of three Lactobacillus plantarum strains isolated from fermented fish, beach sand and a coastal plant were determined. Compared with the type strain L. plantarum NBRC 15891(T), which was isolated from pickled cabbage, L. plantarum Tennozu-SU2 isolated from the acorn of a coastal tree showed high autoaggregation in de Man, Rogosa and Sharpe (MRS) broth and an antagonistic effect against S...
December 10, 2016: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/27934296/identification-of-candidate-host-cell-factors-required-for-actin-based-motility-of-burkholderia-pseudomallei
#13
Niramol Jitprasutwit, Nurhamimah Zainal-Abidin, Charles Vander Broek, Dominic Kurian, Sunee Korbsrisate, Mark P Stevens, Joanne M Stevens
Intracellular actin-based motility of the melioidosis pathogen Burkholderia pseudomallei requires the bacterial factor BimA. Located at one pole of the bacterium, BimA recruits and polymerizes cellular actin to promote bacterial motility within and between cells. Here, we describe an affinity approach coupled with mass spectrometry to identify cellular proteins recruited to BimA-expressing bacteria under conditions that promote actin polymerization. We identified a group of cellular proteins that are recruited to the B...
December 2, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27932462/salmonella-co-opts-host-cell-chaperone-mediated-autophagy-for-intracellular-growth
#14
Vikash Singh, Johannes Finke-Isami, Amanda C Hopper-Chidlaw, Peter Schwerk, Arthur Thompson, Karsten Tedin
Salmonella enterica are invasive, intracellular pathogens which replicate within a membrane-bound compartment inside infected host cells known as the Salmonella-containing vacuole (SCV). How Salmonella obtains nutrients for growth within this intracellular niche despite the apparent isolation is currently not known. Recent studies have indicated the importance of glucose and related carbon sources for tissue colonisation and intracellular proliferation within host cells during Salmonella infections, although none have been found to be essential...
December 8, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27930540/invasive-bacterial-infections-in-gambians-with-sickle-cell-anemia-in-an-era-of-widespread-pneumococcal-and-hemophilus-influenzae-type-b-vaccination
#15
Germander Soothill, Saffiatou Darboe, Gibril Bah, Lawal Bolarinde, Aubrey Cunnington, Suzanne T Anderson
There is relatively little data on the etiology of bacterial infections in patients with sickle cell anemia (SCA) in West Africa, and no data from countries that have implemented conjugate vaccines against both Streptococcus pneumoniae and Haemophilus influenzae type b (Hib).We conducted a retrospective analysis of SCA patients admitted to the Medical Research Council Unit, The Gambia, during a 5-year period when there was high coverage of Hib and Pneumococcal conjugate vaccination. We evaluated 161 admissions of 126 patients between April 2010 and April 2015...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27920299/the-type-iii-secretion-system-effector-sptp-of-salmonella-enterica-serovar-typhi
#16
Rebecca Johnson, Alexander Byrne, Cedric N Berger, Elizabeth Klemm, Valerie F Crepin, Gordon Dougan, Gad Frankel
: Salmonella enterica serovars causes gastroenteritis or typhoid fever in humans, with virulence depending on the action of two type III secretion systems (SPI-1 and SPI-2). SptP is a Salmonella SPI-1 effector, involved in mediating recovery of the host cytoskeleton post-infection. SptP requires a chaperone, SicP, for stability and secretion. SptP has 94% identity between S Typhimurium and S Typhi; direct comparison of the protein sequences revealed that S Typhi SptP has numerous amino acid changes within its chaperone-binding domain...
December 5, 2016: Journal of Bacteriology
https://www.readbyqxmd.com/read/27919296/antimicrobial-resistance-in-salmonella-that-caused-foodborne-disease-outbreaks-united-states-2003-2012
#17
A C Brown, J E Grass, L C Richardson, A L Nisler, A S Bicknese, L H Gould
Although most non-typhoidal Salmonella illnesses are self-limiting, antimicrobial treatment is critical for invasive infections. To describe resistance in Salmonella that caused foodborne outbreaks in the United States, we linked outbreaks submitted to the Foodborne Disease Outbreak Surveillance System to isolate susceptibility data in the National Antimicrobial Resistance Monitoring System. Resistant outbreaks were defined as those linked to one or more isolates with resistance to at least one antimicrobial drug...
December 6, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/27886215/hyperinvasiveness-of-salmonella-enterica-serovar-choleraesuis-linked-to-hyperexpression-of-type-iii-secretion-systems-in-vitro
#18
Kuan-Yeh Huang, Yi-Hsin Wang, Kun-Yi Chien, Rajendra Prasad Janapatla, Cheng-Hsun Chiu
Salmonella enterica serovars Choleraesuis and Typhimurium are among the non-typhoid Salmonella serovars that are important zoonotic pathogens. In clinical observation, S. Typhimurium typically causes diarrheal diseases; however, S. Choleraesuis shows high predilection to cause bacteremia. The mechanism why S. Choleraesuis is more invasive to humans remains unknown. In this study, we compared the S. Typhimurium LT2 and S. Choleraesuis SC-B67 proteomes through stable isotope labeling of amino acid in cell culture (SILAC)...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27880807/human-genome-wide-rnai-screen-for-host-factors-that-facilitate-salmonella-invasion-reveals-a-role-for-potassium-secretion-in-promoting-internalization
#19
Joshua M Thornbrough, Adarsh Gopinath, Tom Hundley, Micah J Worley
Salmonella enterica can actively invade the gastro-intestinal epithelium. This frequently leads to diarrheal disease, and also gives the pathogen access to phagocytes that can serve as vehicles for dissemination into deeper tissue. The ability to invade host cells is also important in maintaining the carrier state. While much is known about the bacterial factors that promote invasion, relatively little is known about the host factors involved. To gain insight into how Salmonella enterica serovar Typhimurium is able to invade normally non-phagocytic cells, we undertook a global RNAi screen with S...
2016: PloS One
https://www.readbyqxmd.com/read/27875307/salmonella-enteritidis-effector-avra-stabilizes-intestinal-tight-junctions-via-the-jnk-pathway
#20
Zhijie Lin, Yong-Guo Zhang, Yinglin Xia, Xiulong Xu, Xinan Jiao, Jun Sun
Salmonella pathogenesis studies to date have focused on Salmonella typhimurium, and the pathogenesis of a second major serotype, Salmonella enteritidis, is poorly understood. Salmonella spp. possess effector proteins that display biochemical activities and modulate host functions. Here, we generated a deletion mutant of the effector AvrA, S.E-AvrA(-), and a plasmid-mediated complementary strain, S.E-AvrA(-)/pAvrA(+) (S.E-AvrA(+)), in S. Enteritidis. Using in vitro and in vivo infection models, we showed that AvrA stabilizes epithelial tight junction (TJ) proteins, such as ZO-1, in human intestinal epithelial cells...
December 23, 2016: Journal of Biological Chemistry
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