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https://www.readbyqxmd.com/read/28302440/kidney-allograft-pyelonephritis-caused-by-salmonella-enterica-serovar-schwarzengrund
#1
Kenta Ito, Haruomi Nishio, Yuji Iwatani, Ryo Yamada, Takao Okawa, Takumi Yamamoto, Masaaki Murakami, Yoko Matsuo, Ken Matsuo, Satoshi Tanaka, Kiyoshi Mori, Noriko Mori
Kidney transplant recipients (KTRs) taking immunosuppressive drugs have a 20-fold greater risk of nontyphoidal Salmonella (NTS) infection than the healthy adult population. Among KTRs, the urinary tract is the most common site of infection. However, few cases of urinary tract infection caused by NTS have been documented in KTRs, and only one in Japan. Furthermore, it frequently induces acute allograft rejection with high mortality. Salmonella enterica subsp. enterica serovar Schwarzengrund (S. Schwarzengrund) is now among the more common Salmonella serovars isolated in Japan and is likely to be invasive...
March 13, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28296382/human-%C3%AE-defensin-6-a-small-peptide-that-self-assembles-and-protects-the-host-by-entangling-microbes
#2
Phoom Chairatana, Elizabeth M Nolan
Human α-defensin 6 (HD6) is a 32-residue cysteine-rich peptide that contributes to innate immunity by protecting the host at mucosal sites. This peptide is produced in small intestinal Paneth cells, stored as an 81-residue precursor peptide named proHD6 in granules, and released into the lumen. One unusual feature of HD6 is that it lacks the broad-spectrum antimicrobial activity observed for other human α-defensins, including the Paneth cell peptide human α-defensin 5 (HD5). HD6 exhibits unprecedented self-assembly properties, which confer an unusual host-defense function...
March 15, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28295924/flagellin-phase-dependent-swimming-on-epithelial-cell-surfaces-contributes-to-productive-salmonella-gut-colonization
#3
Julia A Horstmann, Erik Zschieschang, Theresa Truschel, Juana de Diego, Michele Lunelli, Manfred Rohde, Tobias May, Till Strowig, Theresia Stradal, Michael Kolbe, Marc Erhardt
The flagellum is a sophisticated nanomachine and an important virulence factor of many pathogenic bacteria. Flagellar motility enables directed movements towards host cells in a chemotactic process and near surface swimming on cell surfaces is crucial for selection of permissive entry sites. The long external flagellar filament is made of tens of thousands subunits of a single protein, flagellin, and many Salmonella serovars alternate expression of antigenically distinct flagellin proteins, FliC and FljB. However, the role of the different flagellin variants during gut colonization and host cell invasion remains elusive...
March 13, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28289411/immunogenicity-of-a-bivalent-adjuvanted-glycoconjugate-vaccine-against-salmonella-typhimurium-and-salmonella-enteritidis
#4
Fabio Fiorino, Simona Rondini, Francesca Micoli, Luisa Lanzilao, Renzo Alfini, Francesca Mancini, Calman A MacLennan, Donata Medaglini
Salmonella enterica serovars Typhimurium and Enteritidis are the predominant causes of invasive non-typhoidal Salmonella (iNTS) disease. Considering the co-endemicity of S. Typhimurium and S. Enteritidis, a bivalent vaccine formulation against both pathogens is necessary for protection against iNTS disease, thus investigation of glycoconjugate combination is required. In the present work, we investigated the immune responses induced by S. Typhimurium and S. Enteritidis monovalent and bivalent glycoconjugate vaccines adjuvanted with aluminum hydroxide (alum) only or in combination with cytosine-phosphorothioate-guanine oligodeoxynucleotide (CpG)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28286570/strain-specific-probiotic-properties-of-lactic-acid-bacteria-and-their-interference-with-human-intestinal-pathogens-invasion
#5
Raffaella Campana, Saskia van Hemert, Wally Baffone
BACKGROUND: One of the working mechanisms of probiotic bacteria is their ability to compete with pathogens. To define the probiotic properties of seven Lactic Acid Bacteria (LAB) strains, we tested them for survival in simulated gastro-intestinal conditions, antimicrobial activities, co-aggregative abilities, and interferences studies against five human intestinal pathogens (Salmonella enteritidis ATCC 13076, Listeria monocytogenes ATCC 7644, Escherichia coli O157: H7 ATCC 35150, Cronobacter sakazakii ATCC 29544 and Campylobacter jejuni ATCC 33291)...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28284629/fermented-rapeseed-meal-is-effective-in-controlling-salmonella-enterica-serovar-typhimurium-infection-and-improving-growth-performance-in-broiler-chicks
#6
Amin Ashayerizadeh, Behrouz Dastar, Mahmoud Shams Shargh, Alireza Sadeghi Mahoonak, Saeed Zerehdaran
The aim of present experiment was to assess the effects of fermented rapeseed meal (FRSM) on Salmonella enterica serovar Typhimurium (S. Typhimurium) colonization and growth performance in broiler chicks. Two hundred forty day-old male Cobb 500 broiler chicks were divided into six experimental treatments with four replicates and 10 birds per each. The treatments were including two positive and negative controls which birds received a basal corn-soybean diet as well as four others which birds received the diets that rapeseed meal (RSM) or FRSM was replaced with soybean meal at 50 and 100% levels...
March 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28284594/orally-administered-live-attenuated-salmonella-typhimurium-protects-mice-against-lethal-infection-with-h1n1-influenza-virus
#7
Nitin Machindra Kamble, Irshad Ahmed Hajam, John Hwa Lee
Pre-stimulation of toll-like receptors (TLRs) by agonists has been shown to increase protection against influenza virus infection. In this study, we evaluated the protective response generated against influenza A/Puerto Rico/8/1934 (PR8; H1N1) virus by oral and nasal administration of live attenuated Salmonella enterica serovar Typhimurium, JOL911 strain, in mice. Oral and nasal inoculation of JOL911 significantly increased the mRNA copy number of TLR-2, TLR4 and TLR5, and downstream type I interferon (IFN) molecules, IFN-α and IFN-β, both in peripheral blood mononuclear cells (PBMCs) and in lung tissue...
March 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28264046/an-association-between-decreasing-incidence-of-invasive-non-typhoidal-salmonellosis-and-increased-use-of-antiretroviral-therapy-gauteng-province-south-africa-2003-2013
#8
Karen H Keddy, Simbarashe Takuva, Alfred Musekiwa, Adrian J Puren, Arvinda Sooka, Alan Karstaedt, Keith P Klugman, Frederick J Angulo
BACKGROUND: HIV-infected persons are at increased risk of opportunistic infections, including invasive nontyphoidal Salmonella (iNTS) infections; antiretroviral therapy (ART) reduces this risk. We explored changing iNTS incidence associated with increasing ART availability in South Africa. METHODS: Laboratory-based surveillance for iNTS was conducted in Gauteng Province, South Africa, with verification using the National Health Laboratory Service's Central Data Warehouse (CDW), between 2003 and 2013...
2017: PloS One
https://www.readbyqxmd.com/read/28258000/prevalence-molecular-and-antimicrobial-resistance-of-salmonella-isolated-from-sausages-in-meknes-morocco
#9
Abdelaziz Ed-Dra, Fouzia Rhazi Filali, Bouchra Karraouan, Abdellah El Allaoui, Amal Aboulkacem, Brahim Bouchrif
Salmonella is among the most important food borne pathogens worldwide contaminating a wide range of animal products including meat products. The aims of this study go through two steps: The first step is to estimate the proportion of sausages products contaminated with Salmonella in Meknes city (Morocco), which were collected from various shopping sites: butchery, street vendors, supermarket and souk (Weekly market combines the population of the small villages around Meknes city). The second one is to identify serovars, to determine the antimicrobials resistance patterns of isolates and to detect the invA and spvC genes...
February 28, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28222186/alpk1-controls-tifa-traf6-dependent-innate-immunity-against-heptose-1-7-bisphosphate-of-gram-negative-bacteria
#10
Milica Milivojevic, Anne-Sophie Dangeard, Christoph Alexander Kasper, Therese Tschon, Mario Emmenlauer, Claudine Pique, Pamela Schnupf, Julie Guignot, Cécile Arrieumerlou
During infection by invasive bacteria, epithelial cells contribute to innate immunity via the local secretion of inflammatory cytokines. These are directly produced by infected cells or by uninfected bystanders via connexin-dependent cell-cell communication. However, the cellular pathways underlying this process remain largely unknown. Here we perform a genome-wide RNA interference screen and identify TIFA and TRAF6 as central players of Shigella flexneri and Salmonella typhimurium-induced interleukin-8 expression...
February 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28212413/scarless-deletion-of-up-to-seven-methyl-accepting-chemotaxis-genes-with-an-optimized-method-highlights-key-function-of-chem-in-salmonella-typhimurium
#11
Stefanie Hoffmann, Christiane Schmidt, Steffi Walter, Jennifer K Bender, Roman G Gerlach
Site-directed scarless mutagenesis is an essential tool of modern pathogenesis research. We describe an optimized two-step protocol for genome editing in Salmonella enterica serovar Typhimurium to enable multiple sequential mutagenesis steps in a single strain. The system is based on the λ Red recombinase-catalyzed integration of a selectable antibiotics resistance marker followed by replacement of this cassette. Markerless mutants are selected by expressing the meganuclease I-SceI which induces double-strand breaks in bacteria still harboring the resistance locus...
2017: PloS One
https://www.readbyqxmd.com/read/28197924/sumoylation-as-an-integral-mechanism-in-bacterial-infection-and-disease-progression
#12
Chittur V Srikanth, Smriti Verma
Post translational modification pathways regulate fundamental processes of cells and thus govern vital functions. Among these, particularly the modification with Small Ubiquitin-like Modifiers (SUMO) is being recognized as a pathway crucial for cell homeostasis and health. Understandably, bacterial pathogens intervene with the SUMO pathway of the host for ensuring successful infection. Among the bacterial pathogens known to target host sumoylation varied points of intervention are utilized. Majority of them including Salmonella Typhimurium, Shigella flexneri and Listeria monocytogenes target the E2 conjugating enzyme Ubc9...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28193398/incidence-of-invasive-salmonella-disease-in-sub-saharan-africa-a-multicentre-population-based-surveillance-study
#13
Florian Marks, Vera von Kalckreuth, Peter Aaby, Yaw Adu-Sarkodie, Muna Ahmed El Tayeb, Mohammad Ali, Abraham Aseffa, Stephen Baker, Holly M Biggs, Morten Bjerregaard-Andersen, Robert F Breiman, James I Campbell, Leonard Cosmas, John A Crump, Ligia Maria Cruz Espinoza, Jessica Fung Deerin, Denise Myriam Dekker, Barry S Fields, Nagla Gasmelseed, Julian T Hertz, Nguyen Van Minh Hoang, Justin Im, Anna Jaeger, Hyon Jin Jeon, Leon Parfait Kabore, Karen H Keddy, Frank Konings, Ralf Krumkamp, Benedikt Ley, Sandra Valborg Løfberg, Jürgen May, Christian G Meyer, Eric D Mintz, Joel M Montgomery, Aissatou Ahmet Niang, Chelsea Nichols, Beatrice Olack, Gi Deok Pak, Ursula Panzner, Jin Kyung Park, Se Eun Park, Henintsoa Rabezanahary, Raphaël Rakotozandrindrainy, Tiana Mirana Raminosoa, Tsiriniaina Jean Luco Razafindrabe, Emmanuel Sampo, Heidi Schütt-Gerowitt, Amy Gassama Sow, Nimako Sarpong, Hye Jin Seo, Arvinda Sooka, Abdramane Bassiahi Soura, Adama Tall, Mekonnen Teferi, Kamala Thriemer, Michelle R Warren, Biruk Yeshitela, John D Clemens, Thomas F Wierzba
BACKGROUND: Available incidence data for invasive salmonella disease in sub-Saharan Africa are scarce. Standardised, multicountry data are required to better understand the nature and burden of disease in Africa. We aimed to measure the adjusted incidence estimates of typhoid fever and invasive non-typhoidal salmonella (iNTS) disease in sub-Saharan Africa, and the antimicrobial susceptibility profiles of the causative agents. METHODS: We established a systematic, standardised surveillance of blood culture-based febrile illness in 13 African sentinel sites with previous reports of typhoid fever: Burkina Faso (two sites), Ethiopia, Ghana, Guinea-Bissau, Kenya, Madagascar (two sites), Senegal, South Africa, Sudan, and Tanzania (two sites)...
March 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28182657/modeling-the-potential-for-vaccination-to-diminish-the-burden-of-invasive-non-typhoidal-salmonella-disease-in-young-children-in-mali-west-africa
#14
Kristin Bornstein, Laura Hungerford, David Hartley, John D Sorkin, Milagritos D Tapia, Samba O Sow, Uma Onwuchekwa, Raphael Simon, Sharon M Tennant, Myron M Levine
BACKGROUND: In sub-Saharan Africa, systematic surveillance of young children with suspected invasive bacterial disease (e.g., septicemia, meningitis) has revealed non-typhoidal Salmonella (NTS) to be a major pathogen exhibiting high case fatality (~20%). Where infant vaccination against Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae has been introduced to prevent invasive disease caused by these pathogens, as in Bamako, Mali, their burden has decreased markedly. In parallel, NTS has become the predominant invasive bacterial pathogen in children aged <5 years...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28177798/the-mals-5-utr-regulates-hisg-a-keygene-in-the-histidine-biosynthetic-pathway-in-salmonella-enterica-serovar-typhi
#15
Ying Zhang, Dongmei Yan, Lin Xia, Xin Zhao, George Osei-Adjei, Shungao Xu, Xiumei Sheng, Xinxiang Huang
Bacterial noncoding RNAs regulate diverse cellular processes, including virulence and environmental fitness. The malS-5'UTR was identified as a regulatory ncRNA that increases the invasive capacity of Salmonella enterica serovar Typhi. An IntaRNA search suggested base pairing between malS-5'UTR and hisG mRNA, a key gene in the histidine biosynthetic pathway. Overexpression of malS-5'UTR markly reduced bacterial growth in minimal medium without histidine. Overexpression of malS-5'UTR increased mRNA from his operon genes, independently of the bax gene, and decreased HisG protein in S...
December 2, 2016: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/28149516/salmonella-enteritidis-primary-bacteremia-in-previously-healthy-patient-from-taiwan-case-report
#16
Sevda Mileva, Margarita Gospodinova, Ilian Todorov
BACKGROUND: Diseases caused by invasive nontyphoidal Salmonella strains present with various extraintestinal manifestations, including bacteremia. Factors affecting the incidence include Salmonella serotype, geographic location, and host factors. CASE: We present an unusual case of Salmonella enteritidis primary bacteremia in a patient without any risk factors and originating from a region with the lowest burden of invasive nontyphoidal Salmonella infections. We observed an incomplete clinical response to the treatment with a third-generation cephalosporin, despite the in vitro susceptibility of the strain...
October 2016: Therapeutic Advances in Infectious Disease
https://www.readbyqxmd.com/read/28131374/salmonella-enteritidis-flagellar-mutants-have-a-colonization-benefit-in-the-chicken-oviduct
#17
Sofie Kilroy, Ruth Raspoet, An Martel, Leslie Bosseler, Corinne Appia-Ayme, Arthur Thompson, Freddy Haesebrouck, Richard Ducatelle, Filip Van Immerseel
Egg borne Salmonella Enteritidis is still a major cause of human food poisoning. Eggs can become internally contaminated following colonization of the hen's oviduct. In this paper we aimed to analyze the role of flagella of Salmonella Enteritidis in colonization of the hen's oviduct. Using a transposon library screen we showed that mutants lacking functional flagella are significantly more efficient in colonizing the hen's oviduct in vivo. A micro-array analysis proved that transcription of a number of flagellar genes is down-regulated inside chicken oviduct cells...
February 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28129542/pathogen-mediated-inhibition-of-anorexia-promotes-host-survival-and-transmission
#18
Sheila Rao, Alexandria M Palaferri Schieber, Carolyn P O'Connor, Mathias Leblanc, Daniela Michel, Janelle S Ayres
Sickness-induced anorexia is a conserved behavior induced during infections. Here, we report that an intestinal pathogen, Salmonella Typhimurium, inhibits anorexia by manipulating the gut-brain axis. Inhibition of inflammasome activation by the S. Typhimurium effector, SlrP, prevented anorexia caused by IL-1β-mediated signaling to the hypothalamus via the vagus nerve. Rather than compromising host defenses, pathogen-mediated inhibition of anorexia increased host survival. SlrP-mediated inhibition of anorexia prevented invasion and systemic infection by wild-type S...
January 26, 2017: Cell
https://www.readbyqxmd.com/read/28124965/-bacteremia-caused-by-ciprofloxacin-resistant-salmonella-serotype-kentucky-a-case-report-and-the-review-of-literature
#19
Tuba Müderris, Fatma Yekta Ürkmez, Şeref Alp Küçüker, Muhammet Fethi Sağlam, Gül Ruhsar Yılmaz, Rahmet Güner, Revasiye Güleşen, Ziya Cibali Açıkgöz
Salmonella infections can be seen in four clinical types, namely gastroenteritis, bacteremia/sepsis, enteric fever and carriage. These infections can result in uncomplicated diarrhea in most cases, but can lead to invasive disease requiring antimicrobial therapy and can be life-threatening in elderly or immunocomprimised patients. Broad-spectrum cephalosporins and fluoroquinolones are crucial options in the treatment of the invasive infections. Ciprofloxacin resistance is rarely seen in non-typhoid Salmonella enterica isolates, and only in S...
October 2016: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28089946/identification-by-pcr-signature-tagged-mutagenesis-of-attenuated-salmonella-pullorum-mutants-and-corresponding-genes-in-a-chicken-embryo-model
#20
Shizhong Geng, Qin Tian, Rongxian Guo, Yang Jiao, Paul Barrow, Chao Yin, Yaonan Wang, Haopeng Geng, Zhiming Pan, Xinan Jiao
A key feature of the fowl-specific pathogen Salmonella Pullorum is its vertical transmission to progeny via the egg. In this study, PCR signature-tagged mutagenesis identified nine genes of a strain of S. Pullorum that contributed to survival in the chicken embryo during incubation. The genes were involved in invasion, cell division, metabolism and bacterial defence. The competition index in vivo and in vitro together with a virulence evaluation for chicken embryos of all nine mutant strains confirmed their attenuation...
March 2017: Microbial Pathogenesis
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