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https://www.readbyqxmd.com/read/27886215/hyperinvasiveness-of-salmonella-enterica-serovar-choleraesuis-linked-to-hyperexpression-of-type-iii-secretion-systems-in-vitro
#1
Kuan-Yeh Huang, Yi-Hsin Wang, Kun-Yi Chien, Rajendra Prasad Janapatla, Cheng-Hsun Chiu
Salmonella enterica serovars Choleraesuis and Typhimurium are among the non-typhoid Salmonella serovars that are important zoonotic pathogens. In clinical observation, S. Typhimurium typically causes diarrheal diseases; however, S. Choleraesuis shows high predilection to cause bacteremia. The mechanism why S. Choleraesuis is more invasive to humans remains unknown. In this study, we compared the S. Typhimurium LT2 and S. Choleraesuis SC-B67 proteomes through stable isotope labeling of amino acid in cell culture (SILAC)...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27880807/human-genome-wide-rnai-screen-for-host-factors-that-facilitate-salmonella-invasion-reveals-a-role-for-potassium-secretion-in-promoting-internalization
#2
Joshua M Thornbrough, Adarsh Gopinath, Tom Hundley, Micah J Worley
Salmonella enterica can actively invade the gastro-intestinal epithelium. This frequently leads to diarrheal disease, and also gives the pathogen access to phagocytes that can serve as vehicles for dissemination into deeper tissue. The ability to invade host cells is also important in maintaining the carrier state. While much is known about the bacterial factors that promote invasion, relatively little is known about the host factors involved. To gain insight into how Salmonella enterica serovar Typhimurium is able to invade normally non-phagocytic cells, we undertook a global RNAi screen with S...
2016: PloS One
https://www.readbyqxmd.com/read/27875307/salmonella-enteritidis-effector-avra-stabilizes-intestinal-tight-junctions-via-the-jnk-pathway
#3
Zhijie Lin, Yong-Guo Zhang, Yinglin Xia, Xiulong Xu, Xinan Jiao, Jun Sun
Salmonella pathogenesis studies to date have focused on Salmonella Typhimurium, the pathogenesis of a second major serotype, Salmonella Enteritidis, is poorly understood. Salmonella possess effector proteins that display biochemical activities and modulate the function of host. Here, we generated a deletion mutant of effector AvrA, S.E-AvrA-, and a plasmid-mediated complementary strain, S.E-AvrA-/pAvrA+ (S.E-AvrA+), in Salmonella Enteritidis. Using in vitro and in vivo infection models, we showed that AvrA stabilizes epithelial TJ proteins, such as ZO-1, in human intestinal epithelial cells...
November 15, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27853287/pyroptosis-of-salmonella-typhimurium-infected-macrophages-was-suppressed-and-elimination-of-intracellular-bacteria-from-macrophages-was-promoted-by-blocking-qsec
#4
Zhi Li, Qing Zheng, Xiaoyan Xue, Xin Shi, Ying Zhou, Fei Da, Di Qu, Zheng Hou, Xiaoxing Luo
QseC is a membrane-bound histidine sensor kinase found in Gram-negative pathogens and is involved in the regulation of bacterial virulence. LED209, a QseC-specific inhibitor, significantly inhibits the virulence of several pathogens and partially protects infected mice from death by blocking QseC. However, the mechanism of its antibacterial effects remains unclear. In this experiment, a Salmonella Typhimurium (S. Typhimurium) and macrophage co-culture system was utilized to investigate possible mechanisms underlying the antimicrobial effects of the QseC inhibitor...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27836852/comparative-genomics-reveal-the-diversity-of-restriction-methylation-systems-in-listeria-monocytogenes
#5
Poyin Chen, Henk C den Bakker, Jonas Korlach, Nguyet Kong, Dylan B Storey, Ellen E Paxinos, Meredith Ashby, Tyson Clark, Khai Luong, Martin Wiedmann, Bart C Weimer
: Listeria monocytogenes is a bacterial pathogen that found in a wide variety of anthropogenic and natural environments. Genome sequencing technologies are rapidly becoming a powerful tool in facilitating our understanding of how genotype, classification and virulence phenotypes interact to predict the health risks of individual bacterial isolates. Currently, 57 closed L. monocytogenes genomes are publicly available representing three of the four phylogenetic lineages and suggest L. monocytogenes has high genomic synteny...
November 11, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27828730/characterization-of-resistance-genes-and-plasmids-from-outbreaks-and-illness-clusters-caused-by-salmonella-resistant-to-ceftriaxone-in-the-united-states-2011-2012
#6
Jason P Folster, Julian E Grass, Amelia Bicknese, Julia Taylor, Cindy R Friedman, Jean M Whichard
Salmonella is an important cause of foodborne illness; however, quickly identifying the source of these infections can be difficult, and source identification is a crucial step in preventing additional illnesses. Although most infections are self-limited, invasive salmonellosis may require antimicrobial treatment. Ceftriaxone, an extended-spectrum cephalosporin, is commonly used for treatment of salmonellosis. Previous studies have identified a correlation between the food animal/retail meat source of ceftriaxone-resistant Salmonella and the type of resistance gene and plasmid it carries...
November 9, 2016: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/27817960/multifaceted-immune-responses-and-protective-efficacy-elicited-by-a-recombinant-autolyzed-salmonella-expressing-flic-flagellar-antigen-of-f18-escherichia-coli
#7
Gayeon Won, John Hwa Lee
Porcine edema disease (ED) caused by F18(+) Shiga toxin 2e-producing Escherichia coli (STEC) has imposed significant economic losses in the swine industry worldwide, resulting in sudden deaths in post-weaned piglets. The flagellin protein of F18(+) STEC, a structural component of the flagellar filament, is a known virulence factor that mediates adhesion and invasion to porcine epithelial cells. In this study, Salmonella inactivated by the E lysis gene and expressing the flagellin (fliC) antigen was genetically engineered utilizing a plasmid (pMMP184) carrying an efficient heterologous antigen delivery system...
December 7, 2016: Vaccine
https://www.readbyqxmd.com/read/27807696/common-themes-in-cytoskeletal-remodeling-by-intracellular-bacterial-effectors
#8
Guy Tran Van Nhieu, Stéphane Romero
Bacterial pathogens interact with various types of tissues to promote infection. Because it controls the formation of membrane extensions, adhesive processes, or the junction integrity, the actin cytoskeleton is a key target of pathogens during infection. We will highlight common and specific functions of the actin cytoskeleton during bacterial infections, by first reviewing the mechanisms of intracellular motility of invasive Shigella, Listeria, and Rickettsia. Through the models of EPEC/EHEC, Shigella, Salmonella, and Chlamydia spp...
November 3, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27803173/inhibition-of-phagocytosis-and-pyroptosis-of-macrophages-promotes-bartonella-invasion-into-the-bloodstream-through-lymphatic-circulation
#9
Jiehua Hong, Yan Li, Xiuguo Hua, Yajie Bai, Chunyan Wang, Caixia Zhu, Yuming Du, Zhibiao Yang, Congli Yuan
The hallmark of Bartonella infection is long-lasting intra-erythrocytic parasitism. However, the process of Bartonella bacteremia is still enigmatic. Here, we used Bartonella tribocorum (Bt) to understand how Bartonella invasion into the bloodstream from dermal inoculation might occur. Bartonella was poorly phagocytized by peritoneal macrophages in vitro. Intracellular Bartonella survived and replicated in macrophages at early stage of infection. Intracellular Bartonella inhibited spontaneous cell death of macrophage...
October 31, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27798599/microcins-mediate-competition-among-enterobacteriaceae-in-the-inflamed-gut
#10
Martina Sassone-Corsi, Sean-Paul Nuccio, Henry Liu, Dulcemaria Hernandez, Christine T Vu, Amy A Takahashi, Robert A Edwards, Manuela Raffatellu
The Enterobacteriaceae are Gram-negative bacteria and include commensal organisms as well as primary and opportunistic pathogens that are among the leading causes of morbidity and mortality worldwide. Although Enterobacteriaceae often comprise less than 1% of a healthy intestine's microbiota(1), some of these organisms can bloom in the inflamed gut(2,3,4,5); indeed, expansion of enterobacteria is a hallmark of microbial imbalance known as "dysbiosis"(6). Microcins are small secreted proteins that possess antimicrobial activity in vitro(7,8), but whose role in vivo has been unclear...
October 31, 2016: Nature
https://www.readbyqxmd.com/read/27796997/comparing-tio2-photocatalysis-and-uv-c-radiation-for-inactivation-and-mutant-formation-of-salmonella-typhimurium-ta102
#11
Antonino Fiorentino, Luigi Rizzo, Hélène Guilloteau, Xavier Bellanger, Christophe Merlin
Salmonellosis is one of the most common causes of foodborne bacterial human disease worldwide, and the emergence of multidrug-resistant (MDR) strains of Salmonella enterica serovar Typhimurium (S. typhimurium) was associated to the incidence of invasive salmonellosis. The objective of the present work was to investigate the effects of the TiO2 photocatalysis process in terms of both bacteria inactivation and the emergence of mutants, on S. typhimurium TA102 water suspensions. The TiO2 photocatalysis was compared with a conventional disinfection process such as UV-C radiation...
October 31, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27793824/salmonella-serovar-kentucky-flagella-is-required-for-broiler-skin-adhesion-and-caco-2-cell-invasion
#12
Sanaz Salehi, Kevin Howe, Mark L Lawrence, John P Brooks, R Hartford Bailey, Attila Karsi
: Non-typhoidal Salmonella are the main source of pathogenic bacterial contamination in the poultry industry. Recently, Salmonella enterica serovar Kentucky has been recognized as the most prominent serovar on carcasses in poultry processing plants. Previous studies showed that flagella are one of the main factors that contribute to bacterial attachment to broiler skin. However, the precise role of flagella and mechanism of attachment are unknown. There are two different flagella subunits (fliC and fljB) expressed alternatively in Salmonella enterica serovars using phase variation...
October 28, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27785128/virulence-associated-genes-deleted-salmonella-montevideo-is-attenuated-highly-immunogenic-and-confers-protection-against-virulent-challenge-in-chickens
#13
Jonathan Lalsiamthara, John H Lee
To construct a novel live vaccine against Salmonella enterica serovar Montevideo (SM) infection in chickens, two important bacterial regulatory genes, lon and cpxR, which are associated with invasion and virulence, were deleted from the wild type SM genome. Attenuated strains, JOL1625 (Δlon), JOL1597 (ΔcpxR), and JOL1599 (ΔlonΔcpxR) were thereby generated. Observations with scanning electron microscopy suggested that JOL1625 and JOL1599 cells showed increased ruffled surface which may be related to abundant extracellular polysaccharide (EPS) production...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27779831/infectious-diseases-in-poland-in-2014
#14
Małgorzata Sadkowska-Todys, Andrzej Zieliński, Mirosław P Czarkowski
PURPOSE of the STUDY: The aim of the study is to assess epidemiological situation of infectious and parasitic diseases in Poland in 2014, and an indication of the potential health risks from communicable diseases occurring in other areas of the globe. MATERIAL AND METHODS: This paper is a summary of the analysis and evaluation of the results of epidemiological surveillance of infectious diseases in Poland in 2014, and those elements of European and global epidemiological background, which in this period had an impact on the epidemiological situation in Poland or constituted a threat...
2016: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/27765795/disseminated-infections-with-antibiotic-resistant-non-typhoidal-salmonella-strains-contributions-of-host-and-pathogen-factors
#15
Kristen L Lokken, Gregory T Walker, Renée M Tsolis
Non-typhoidal Salmonella enterica serovars (NTS) are generally associated with gastroenteritis; however, the very young and elderly, as well as individuals with compromised immunity, are at risk of developing disseminated infection that can manifest as bacteremia or focal infections at systemic sites. Disseminated NTS infections can be fatal and are responsible for over 600,000 deaths annually. Most of these deaths are in sub-Saharan Africa, where multi-drug resistant NTS clones are currently circulating in a population with a high proportion of individuals that are susceptible to disseminated disease...
October 8, 2016: Pathogens and Disease
https://www.readbyqxmd.com/read/27756305/bcsz-inhibits-biofilm-phenotypes-and-promotes-virulence-by-blocking-cellulose-production-in-salmonella-enterica-serovar-typhimurium
#16
Irfan Ahmad, Syed Fazle Rouf, Lei Sun, Annika Cimdins, Sulman Shafeeq, Soazig Le Guyon, Marco Schottkowski, Mikael Rhen, Ute Römling
BACKGROUND: Cellulose, a 1,4 beta-glucan polysaccharide, is produced by a variety of organisms including bacteria. Although the production of cellulose has a high biological, ecological and economical impact, regulatory mechanisms of cellulose biosynthesis are mostly unknown. Family eight cellulases are regularly associated with cellulose biosynthesis operons in bacteria; however, their function is poorly characterized. In this study, we analysed the role of the cellulase BcsZ encoded by the bcsABZC cellulose biosynthesis operon of Salmonella enterica serovar Typhimurium (S...
October 19, 2016: Microbial Cell Factories
https://www.readbyqxmd.com/read/27754876/salmonella-typhimurium-enzymatically-landscapes-the-host-intestinal-epithelial-cell-iec-surface-glycome-to-increase-invasion
#17
Dayoung Park, Narine Arabyan, Cynthia C Williams, Ting Song, Anupam Mitra, Bart C Weimer, Emanual Maverakis, Carlito B Lebrilla
Although gut host-pathogen interactions are glycan-mediated processes, few details are known about the participating structures. Here we employ high-resolution mass spectrometric profiling to comprehensively identify and quantitatively measure the exact modifications of native intestinal epithelial cell surface N-glycans induced by S. typhimurium infection. Sixty minutes postinfection, select sialylated structures showed decreases in terms of total number and abundances. To assess the effect of cell surface mannosylation, we selectively rerouted glycan expression on the host using the alpha-mannosidase inhibitor, kifunensine, toward overexpression of high mannose...
December 2016: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/27753515/tbk1-directs-wipi2-against-salmonella
#18
Keith B Boyle, Teresa L M Thurston, Felix Randow
Defense of the mammalian cell cytosol against Salmonella invasion is reliant upon capture of the infiltrating bacteria by macroautophagy (hereafter autophagy), a process controlled by the kinase TBK1. In our recent study we showed that recruitment of TBK1 activity to Salmonella stabilizes the key autophagy regulator WIPI2 on those bacteria, a novel and essential function for TBK1 in the control of the early steps of antibacterial autophagy. Substantial redundancy exists in the precise recruitment mechanism for TBK1 because engagement with any of several Salmonella-associated 'eat-me' signals, including host-derived glycans, and K48- and K63-linked ubiquitin chains, suffices to recruit TBK1 functionality...
October 18, 2016: Autophagy
https://www.readbyqxmd.com/read/27738122/effect-of-propionibacterium-freudenreichii-on-salmonella-multiplication-motility-and-association-with-avian-epithelial-cells
#19
Divek V T Nair, A Kollanoor-Johny
We investigated the effects of a probiotic bacterium, Propionibacterium freudenreichii, on Salmonella multiplication, motility, and association to and invasion of avian epithelial cells in vitro. Two subspecies of P. freudenreichii (P. freudenreichii subsp. freudenreichii and P. freudenreichii subsp. shermanii) were tested against 3 Salmonella serotypes in poultry, namely, S. Enteritidis, S. Typhimurium, and S. Heidelberg, using co-culture-, motility, multiplication, cell association, and invasion assays. Both strains of P...
October 12, 2016: Poultry Science
https://www.readbyqxmd.com/read/27711220/acute-infectious-gastroenteritis-potentiates-a-crohn-s-disease-pathobiont-to-fuel-ongoing-inflammation-in-the-post-infectious-period
#20
Cherrie L Small, Lydia Xing, Joseph B McPhee, Hong T Law, Brian K Coombes
Crohn's disease (CD) is a chronic inflammatory condition of diverse etiology. Exposure to foodborne pathogens causing acute gastroenteritis produces a long-term risk of CD well into the post-infectious period but the mechanistic basis for this ongoing relationship to disease onset is unknown. We developed two novel models to study the comorbidity of acute gastroenteritis caused by Salmonella Typhimurium or Citrobacter rodentium in mice colonized with adherent-invasive Escherichia coli (AIEC), a bacterial pathobiont linked to CD...
October 2016: PLoS Pathogens
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