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https://www.readbyqxmd.com/read/29901711/autotransporter-misl-of-salmonella-enterica-serotype-typhimurium-facilitates-bacterial-aggregation-and-biofilm-formation
#1
Shaohui Wang, Denghui Yang, Xiaojun Wu, Yang Wang, Dong Wang, Mingxing Tian, Tao Li, Jingjing Qi, Xiaolan Wang, Chan Ding, Shengqing Yu
Salmonella enterica serovar Typhimurium (S. Typhimurium) is an important food-borne zoonotic pathogen that causes increased morbidity and mortality worldwide. The autotransporter (AT) proteins are a large and diverse family of extracellular proteins, many of which contribute to the pathogenicity of Gram-negative bacteria. The S. Typhimurium AT protein MisL mediates intestinal colonization in mice. Bioinformatics analyses indicated that MisL clusters with ATs involved in bacterial biofilm formation, aggregation and adherence...
June 12, 2018: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29885024/septin-regulated-actin-dynamics-promote-salmonella-invasion-of-host-cells
#2
Kirsten C Boddy, Aggie Duan Gao, Dorothy Truong, Moshe S Kim, Carol D Froese, William S Trimble, John H Brumell
Actin nucleators and their binding partners play crucial roles during Salmonella invasion, but how these factors are dynamically coordinated remains unclear. Here, we show that septins, a conserved family of GTPases, play a role during the early stages of Salmonella invasion. We demonstrate that septins are rapidly recruited to sites of bacterial entry and contribute to the morphology of invasion ruffles. Expression of Septin 2, Septin 7 and Septin 9 is required for efficient bacterial invasion. We found that septins contribute to the recruitment of ROCK2 kinase during Salmonella invasion and the downstream activation of the actin nucleating protein FHOD1...
June 8, 2018: Cellular Microbiology
https://www.readbyqxmd.com/read/29879120/crp-camp-mediates-silencing-of-salmonella-virulence-at-the-post-transcriptional-level
#3
Youssef El Mouali, Tania Gaviria-Cantin, María Antonia Sánchez-Romero, Marta Gibert, Alexander J Westermann, Jörg Vogel, Carlos Balsalobre
Invasion of epithelial cells by Salmonella enterica requires expression of genes located in the pathogenicity island I (SPI-1). The expression of SPI-1 genes is very tightly regulated and activated only under specific conditions. Most studies have focused on the regulatory pathways that induce SPI-1 expression. Here, we describe a new regulatory circuit involving CRP-cAMP, a widely established metabolic regulator, in silencing of SPI-1 genes under non-permissive conditions. In CRP-cAMP-deficient strains we detected a strong upregulation of SPI-1 genes in the mid-logarithmic growth phase...
June 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29867881/identification-and-characterization-of-a-cis-antisense-rna-of-the-rpoh-gene-of-salmonella-enterica-serovar-typhi
#4
Changyan Xiong, Xuejiao Li, Juanli Liu, Xin Zhao, Shungao Xu, Xinxiang Huang
Antisense RNAs from complementary strands of protein coding genes regulate the expression of genes involved in many cellular processes. Using deep sequencing analysis of the Salmonella enterica serovar Typhi ( S. Typhi) transcriptome, a novel antisense RNA encoded on the strand complementary to the rpoH gene was revealed. In this study, the molecular features of this antisense RNA were assessed using northern blotting and rapid amplification of cDNA ends. The 3,508 nt sequence of RNA was identified as the antisense RNA of the rpoH gene and was named ArpH...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29867804/polyphyletic-nature-of-salmonella-enterica-serotype-derby-and-lineage-specific-host-association-revealed-by-genome-wide-analysis
#5
Yann Sévellec, Marie-Léone Vignaud, Sophie A Granier, Renaud Lailler, Carole Feurer, Simon Le Hello, Michel-Yves Mistou, Sabrina Cadel-Six
In France, Salmonella Derby is one of the most prevalent serotypes in pork and poultry meat. Since 2006, it has ranked among the 10 most frequent Salmonella serotypes isolated in humans. In previous publications, Salmonella Derby isolates have been characterized by pulsed field gel electrophoresis (PFGE) and antimicrobial resistance (AMR) profiles revealing the existence of different pulsotypes and AMR phenotypic groups. However, these results suffer from the low discriminatory power of these typing methods...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29866910/methylthioadenosine-suppresses-salmonella-virulence
#6
Jeffrey S Bourgeois, Daoguo Zhou, Teresa L M Thurston, James J Gilchrist, Dennis C Ko
In order to deploy virulence factors at appropriate times and locations, microbes must rapidly sense and respond to various metabolite signals. Previously we showed transient elevation of the methionine-derived metabolite methylthioadenosine (MTA) in serum during systemic Salmonella enterica serovar Typhimurium ( S. Typhimurium) infection. Here we explored the functional consequences of increased MTA concentrations on S. Typhimurium virulence. We found that MTA-but not other related metabolites involved in polyamine synthesis and methionine salvage-reduced motility, host cell pyroptosis, and cellular invasion...
June 4, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29791435/immunogenicity-and-efficacy-following-sequential-parenterally-administered-doses-of-salmonella-enteritidis-cops-flic-glycoconjugates-in-infant-and-adult-mice
#7
Scott M Baliban, Brittany Curtis, Deanna Toema, Sharon M Tennant, Myron M Levine, Marcela F Pasetti, Raphael Simon
In sub-Saharan Africa, invasive nontyphoidal Salmonella (iNTS) infections with serovars S. Enteritidis, S. Typhimurium and I 4,[5],12:i:- are widespread in children < 5 years old. Development of an efficacious vaccine would provide an important public health tool to prevent iNTS disease in this population. Glycoconjugates of S. Enteritidis core and O-polysaccharide (COPS) coupled to the homologous serovar phase 1 flagellin protein (FliC) were previously shown to be immunogenic and protected adult mice against death following challenge with a virulent Malian S...
May 23, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29790462/negligible-import-of-enteric-pathogens-by-newly-arrived-asylum-seekers-and-no-impact-on-incidence-of-notified-salmonella-and-shigella-infections-and-outbreaks-in-rhineland-palatinate-germany-january-2015-to-may-2016
#8
Lutz Ehlkes, Maja George, Donald Knautz, Florian Burckhardt, Klaus Jahn, Manfred Vogt, Philipp Zanger
IntroductionThe 2015 refugee crisis raised concerns about an import of infectious diseases affecting the German population. Aims: To evaluate public and individual health benefits of stool screening, and explore whether importation of enteric pathogens by newly-arrived asylum seekers impacts on the host population. Methods : We used data from mandatory stool screening to determine the overall, age, sex, and country-specific prevalence of enteric bacteria and helminths. We used surveillance data to assess whether the number of incoming asylum seekers influenced notifications of salmonellosis and shigellosis in Rhineland-Palatinate...
May 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29788466/in-vivo-and-in-vitro-evaluation-of-tissue-colonization-and-survival-capacity-of-salmonella-oranienburg-in-laying-hens
#9
Uma S Babu, Monika Proszkowiec-Weglarz, Girdhari M Sharma, Marion Pereira, Kannan V Balan
Salmonella enterica serovar Oranienburg (SO) was linked to a human salmonellosis outbreak in the Midwest in 2015 and 2016 from consumption of eggs. However, unlike Salmonella enterica serovar Enteritidis (SE), little is known regarding the potential of SO to colonize in laying hens and contaminate eggs. We used in vivo and in vitro models to evaluate tissue colonization and survival capacity of SO. Twenty eight-week-old laying hens were each challenged with an oral dose of approximately 107 (n = 92) or 109 (n = 96) colony-forming units (CFU) in 1 mL saline and evaluated after 1, 2, and 4 wk...
May 18, 2018: Poultry Science
https://www.readbyqxmd.com/read/29785632/virulence-factors-in-salmonella-typhimurium-the-sagacity-of-a-bacterium
#10
REVIEW
Anamaria M P Dos Santos, Rafaela G Ferrari, Carlos A Conte-Junior
Currently, Salmonella enterica Typhimurium (ST) is responsible for most cases of food poisoning in several countries. It is characterized as a non-specific zoonotic bacterium that can infect both humans and animals and although most of the infections caused by this microorganism cause only a self-limiting gastroenteritis, some ST strains have been shown to be invasive, crossing the intestinal wall and reaching the systemic circulation. This unusual pathogenicity ability is closely related to ST virulence factors...
May 21, 2018: Current Microbiology
https://www.readbyqxmd.com/read/29779148/in-vitro-virulence-characteristics-of-rare-serovars-of-salmonella-enterica-isolated-from-sand-lizards-lacerta-agilis-l
#11
Joanna Mokracka, Sylwia Krzymińska, Danił Ałtunin, Dariusz Wasyl, Ryszard Koczura, Krzysztof Dudek, Monika Dudek, Zofia Anna Chyleńska, Anna Ekner-Grzyb
The aim of this study was to estimate virulence potential of Salmonella enterica strains colonizing the gut of free-living sand lizards (Lacerta agilis L.). The strains belonged to three Salmonella serovars: Abony, Schleissheim, and Telhashomer. Adhesion and invasion abilities of the strains were determined in quantitative assays using the gentamicin protection method. Induction of apoptosis was assessed using HeLa cell monolayers. PCR assays were used for detection of 26 virulence genes localised within mobile elements: pathogenicity islands, virulence plasmids, and prophage sequences...
May 19, 2018: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29777131/activity-of-acetyltransferase-toxins-involved-in-salmonella-persister-formation-during-macrophage-infection
#12
Julian A Rycroft, Bridget Gollan, Grzegorz J Grabe, Alexander Hall, Angela M Cheverton, Gerald Larrouy-Maumus, Stephen A Hare, Sophie Helaine
Non-typhoidal Salmonella strains are responsible for invasive infections associated with high mortality and recurrence in sub-Saharan Africa, and there is strong evidence for clonal relapse following antibiotic treatment. Persisters are non-growing bacteria that are thought to be responsible for the recalcitrance of many infections to antibiotics. Toxin-antitoxin systems are stress-responsive elements that are important for Salmonella persister formation, specifically during infection. Here, we report the analysis of persister formation of clinical invasive strains of Salmonella Typhimurium and Enteritidis in human primary macrophages...
May 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29768564/meningitis-caused-by-salmonella-enterica-serotype-panama-in-brazil-first-case-reported
#13
Maria Regina Pires Carneiro, Maria Iracema de Aguiar Patrício, Sona Jain, Dalia Dos Prazeres Rodrigues, Sergio Eduardo Longo Fracalanzza
Salmonella infections usually occur as gastroenteritis that is generally self-limited. However, some serotypes of Salmonella can cause severe extra-intestinal infections, such as bacteremia and meningitis. Here, we report the first Salmonella Panama case of meningitis in 4-month-old male newborn in Brazil. The invasive strain isolated was susceptible to all antimicrobial agents tested. The genes agfA, fimA, invA, sfbA, phoP, and slyA were detected using polymerase chain reactions. These findings are relevant and physicians should be alert to the possibility of meningitis in newborns due to S...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29761650/in-vitro-and-in-vivo-efficacy-of-a-live-attenuated-salmonella-typhimurium-vaccine-at-preventing-intestinal-colonization-in-chicks
#14
Alexander J Howard, Kapil K Chousalkar, Andrea R McWhorter
Vaccination of chicks with Salmonella (S.) Typhimurium aroA deletion mutants has previously been shown to inhibit intestinal colonization of wild-type S. Typhimurium strains. In Australia, Bioproperties VaxSafe™ STM1 strain is the only licensed and commercially available S. Typhimurium vaccine. This vaccine is a live attenuated aroA deletion mutant. Currently, it is recommended that the first dose of the STM1 vaccine is administered through coarse spray. It is unclear whether this mode of administration effectively permits intestinal colonization...
May 14, 2018: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29761161/natural-compound-sanguinarine-chloride-targets-the-type-iii-secretion-system-of-salmonella-enterica-serovar-typhimurium
#15
Yong Zhang, Yan Liu, Tingting Wang, Xuming Deng, Xiao Chu
The type III secretion system (T3SS) is a key virulence mechanism of many Gram-negative bacterial pathogens. Upon contact between bacteria and host cells, T3SS transfers a series of effectors from the bacterial cytosol to host cells. It is widely known that a mutation in T3SS does not impair bacterial growth, thereby avoiding any subsequent development of resistance. Thus, T3SS is expected to be a candidate therapeutic target. While developing the T3SS screening method, we discovered that sanguinarine chloride, a natural compound, could decrease the production of the SPI-1 type III secretion system main virulence proteins SipA and SipB and prevent the invasion of HeLa cells by Salmonella enterica serovar Typhimurium without affecting the growth of Salmonella...
July 2018: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/29752442/publisher-correction-hild-and-phop-independently-regulate-the-expression-of-grhd1-a-novel-gene-required-for-salmonella-typhimurium-invasion-of-host-cells
#16
María M Banda, Carolina López, Rubiceli Manzo, Gadea Rico-Pérez, Pablo García, Roberto Rosales-Reyes, Miguel A De la Cruz, Fernando C Soncini, Francisco García-Del Portillo, Víctor H Bustamante
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
May 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29750790/fecal-microbiome-of-periparturient-dairy-cattle-and-associations-with-the-onset-of-salmonella-shedding
#17
Lohendy Muñoz-Vargas, Stephen O Opiyo, Rose Digianantonio, Michele L Williams, Asela Wijeratne, Gregory Habing
Non-typhoidal Salmonella enterica is a zoonotic pathogen with critical importance in animal and public health. The persistence of Salmonella on farms affects animal productivity and health, and represents a risk for food safety. The intestinal microbiota plays a fundamental role in the colonization and invasion of this ubiquitous microorganism. To overcome the colonization resistance imparted by the gut microbiome, Salmonella uses invasion strategies and the host inflammatory response to survive, proliferate, and establish infections with diverse clinical manifestations...
2018: PloS One
https://www.readbyqxmd.com/read/29746835/complement-c3-drives-autophagy-dependent-restriction-of-cyto-invasive-bacteria
#18
Matthew T Sorbara, Elisabeth G Foerster, Jessica Tsalikis, Mena Abdel-Nour, Joseph Mangiapane, Imogen Sirluck-Schroeder, Ivan Tattoli, Rob van Dalen, David E Isenman, John R Rohde, Stephen E Girardin, Dana J Philpott
In physiological settings, the complement protein C3 is deposited on all bacteria, including invasive pathogens. However, because experimental host-bacteria systems typically use decomplemented serum to avoid the lytic action of complement, the impact of C3 coating on epithelial cell responses to invasive bacteria remains unexplored. Here, we demonstrate that following invasion, intracellular C3-positive Listeria monocytogenes is targeted by autophagy through a direct C3/ATG16L1 interaction, resulting in autophagy-dependent bacterial growth restriction...
May 9, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29746615/what-is-the-best-immunization-strategy-for-protecting-african-children-against-invasive-salmonella-disease
#19
Hyon Jin Jeon, Gi Deok Pak, Justin Im, Ellis Owusu-Dabo, Yaw Adu-Sarkodie, Amy Gassama Sow, Abdramane Soura Bassiahi, Nagla Gasmelseed, Karen H Keddy, Morten Bjerregaard-Andersen, Frank Konings, Abraham Aseffa, John A Crump, Yun Chon, Robert F Breiman, Se Eun Park, Ligia Maria Cruz Espinoza, Hye Jin Seo, Jürgen May, Christian G Meyer, Jason R Andrews, Ursula Panzner, Vera von Kalckreuth, Thomas F Wierzba, Raphaël Rakotozandrindrainy, Gordon Dougan, Myron M Levine, Joachim Hombach, Jerome H Kim, John D Clemens, Stephen Baker, Florian Marks
Background: The WHO recently prequalified a typhoid conjugate vaccine (TCV), recommending its use in persons aged ≥6 months to 45 years residing in typhoid fever (TF)-endemic areas. We now need to consider how TCVs can have the greatest impact in the most vulnerable populations in Africa. Methods: The Typhoid Fever Surveillance in Africa Program (TSAP) in 10 sub-Saharan African countries included blood culture-based surveillance in febrile people presenting at healthcare-facilities originating from defined catchment areas...
May 9, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29738521/machine-learning-identifies-signatures-of-host-adaptation-in-the-bacterial-pathogen-salmonella-enterica
#20
Nicole E Wheeler, Paul P Gardner, Lars Barquist
Emerging pathogens are a major threat to public health, however understanding how pathogens adapt to new niches remains a challenge. New methods are urgently required to provide functional insights into pathogens from the massive genomic data sets now being generated from routine pathogen surveillance for epidemiological purposes. Here, we measure the burden of atypical mutations in protein coding genes across independently evolved Salmonella enterica lineages, and use these as input to train a random forest classifier to identify strains associated with extraintestinal disease...
May 2018: PLoS Genetics
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