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https://www.readbyqxmd.com/read/29666286/viable-but-nonculturable-listeria-monocytogenes-and-salmonella-enterica-serovar-thompson-induced-by-chlorine-stress-remain-infectious
#1
Callum J Highmore, Jennifer C Warner, Steve D Rothwell, Sandra A Wilks, C William Keevil
The microbiological safety of fresh produce is monitored almost exclusively by culture-based detection methods. However, bacterial food-borne pathogens are known to enter a viable-but-nonculturable (VBNC) state in response to environmental stresses such as chlorine, which is commonly used for fresh produce decontamination. Here, complete VBNC induction of green fluorescent protein-tagged Listeria monocytogenes and Salmonella enterica serovar Thompson was achieved by exposure to 12 and 3 ppm chlorine, respectively...
April 17, 2018: MBio
https://www.readbyqxmd.com/read/29660095/effect-of-dietary-bacillus-coagulans-supplementation-on-growth-performance-and-immune-responses-of-broiler-chickens-challenged-by-salmonella-enteritidis
#2
Wenrui Zhen, Yujing Shao, Xiuyan Gong, Yuanyuan Wu, Yanqiang Geng, Zhong Wang, Yuming Guo
This study was conducted to evaluate the protective efficacy of dietary Bacillus coagulans (B. coagulans) supplementation in birds receiving Salmonella enteritidis (SE). Two hundred and forty 1-day-old Cobb broilers were randomly assigned to 2 × 2 factorial arrangements of treatments with 2 levels of dietary B. coagulans (0 or 400 mg/kg) and 2 levels of SE challenge (0 or 1 × 109 SE between d 9 to 11). Results showed that SE infection did not affect growth performance, but caused intestinal inflammation and barrier function impairment by reducing intestinal goblet cells and beneficial bacteria numbers, increasing cecal Salmonella colonization and liver Salmonella invasion, downregulating jejunal mucin-2 (at 7 and 17 d post-infection, DPI), TLR2 (at 7 and 17 DPI), TLR4 (at 17 DPI), TNFSF15 (at 7 and 17 DPI) gene mRNA levels, and upregulating jejunal IFN-γ mRNA levels (at 17 DPI) compared to uninfected birds...
April 11, 2018: Poultry Science
https://www.readbyqxmd.com/read/29628924/defective-phagocytic-properties-of-hiv-infected-macrophages-how-might-they-be-implicated-in-the-development-of-invasive-salmonella-typhimurium
#3
REVIEW
Gabrielle Lê-Bury, Florence Niedergang
Human immunodeficiency virus type 1 (HIV-1) infects and kills T cells, profoundly damaging the host-specific immune response. The virus also integrates into memory T cells and long-lived macrophages, establishing chronic infections. HIV-1 infection impairs the functions of macrophages both in vivo and in vitro , which contributes to the development of opportunistic diseases. Non-typhoidal Salmonella enterica serovar Typhimurium has been identified as the most common cause of bacterial bloodstream infections in HIV-infected adults...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29628470/a-rare-case-of-rush-progression-of-purulent-pericarditis-by-escherichia-coli-in-a-patient-with-malignant-lymphoma
#4
Shunpei Horii, Hirotaka Yada, Kei Ito, Ayumu Osaki, Atsushi Sato, Toyokazu Kimura, Risako Yasuda, Takumi Toya, Takayuki Namba, Nobuyuki Masaki, Takeshi Adachi
Purulent pericarditis is a rare disease in the antibiotic era. The common pathogens of purulent pericarditis are gram-positive species such as Staphylococcus aureus. Streptococcus pneumoniae, Salmonella, Haemophilus, fungal pathogens/tuberculosis can also result in purulent pericarditis. We report an old male case of purulent pericarditis by Escherichia coli. He came to our hospital suffering from leg edema for 3 months. Echocardiography revealed the large amount of pericardial effusion, and he was admitted to test the cause of pericardial effusion without high fever, tachycardia, and shock vital signs...
April 6, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29626750/novel-regulatory-roles-of-wnt1-in-infection-associated-colorectal-cancer
#5
Jianwei Wang, Rong Lu, Xinghui Fu, Zhou Dan, Yong-Guo Zhang, Xinxia Chang, Qisha Liu, Yinglin Xia, Xingyin Liu, Jun Sun
Salmonella infection is a major public health concern, and colonization in humans can be chronic and increases the risk of cancers. Wnt signaling is a key pathway for intestinal renewal and development, inflammation, and tumorigenesis. In the current study, we report a novel role of Wnt1 in infection and colon cancer using cell culture models, a Salmonella-colitis colon cancer model, and human samples. In contrast to the bacteria-induced increases in Wnt2 and Wnt11, Salmonella colonization significantly reduced the level of Wnt1 in intestinal epithelial cells in vivo and in vitro...
April 4, 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29608333/predictive-modeling-for-the-growth-of-salmonella-enteritidis-in-chicken-juice-by-real-time-polymerase-chain-reaction
#6
Fia Noviyanti, Yukie Hosotani, Shigenobu Koseki, Yasuhiro Inatsu, Susumu Kawasaki
The goals of this study were to monitor the growth kinetics of Salmonella Enteritidis in chicken juice using real-time polymerase chain reaction (PCR) and to evaluate its efficacy by comparing the results with an experimental database. Salmonella Enteritidis was inoculated in chicken juice samples at an initial inoculum of 104 CFU/mL with inoculated samples incubated at six different temperatures (10, 15, 20, 25, 30, and 35°C). Sampling was carried out for 36 h to observe the growth of Salmonella Enteritidis...
April 2, 2018: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/29605531/high-prevalence-of-ceftriaxone-resistance-among-invasive-salmonella-enterica-serotype-choleraesuis-isolates-in-thailand-the-emergence-and-increase-of-ctx-m-55-in-ciprofloxacin-resistant-s-choleraesuis-isolates
#7
Sirirat Luk-In, Tanittha Chatsuwan, Chaiwat Pulsrikarn, Aroon Bangtrakulnonth, Ubolrat Rirerm, Wanla Kulwichit
S. Choleraesuis is a highly invasive zoonotic pathogen that causes a serious systemic infection in humans. The emergence and increase of resistance to ceftriaxone and ciprofloxacin among S. Choleraesuis has become a serious therapeutic problem. The present study demonstrated high frequency of antimicrobial resistance in Salmonella Choleraesuis among 414 nontyphoidal Salmonella isolates from bacteremic patients in Thailand. High rates of ceftriaxone (58.3%) and ciprofloxacin (19.6%) resistances were observed in S...
March 23, 2018: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29593692/optimized-co-extraction-and-quantification-of-dna-from-enteric-pathogens-in-surface-water-samples-near-produce-fields-in-california
#8
Michael B Cooley, Diana Carychao, Lisa Gorski
Pathogen contamination of surface water is a health hazard in agricultural environments primarily due to the potential for contamination of crops. Furthermore, pathogen levels in surface water are often unreported or under reported due to difficulty with culture of the bacteria. The pathogens are often present, but require resuscitation, making quantification difficult. Frequently, this leads to the use of quantitative PCR targeted to genes unique to the pathogens. However, multiple pathogen types are commonly in the same water sample, both gram + and gram -, leading to problems with DNA extraction...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29570602/live-bacterial-vectors-a-promising-dna-vaccine-delivery-system
#9
REVIEW
Valentina Yurina
Vaccination is one of the most successful immunology applications that has considerably improved human health. The DNA vaccine is a new vaccine being developed since the early 1990s. Although the DNA vaccine is promising, no human DNA vaccine has been approved to date. The main problem facing DNA vaccine efficacy is the lack of a DNA vaccine delivery system. Several studies explored this limitation. One of the best DNA vaccine delivery systems uses a live bacterial vector as the carrier. The live bacterial vector induces a robust immune response due to its natural characteristics that are recognized by the immune system...
March 23, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29555922/hild-and-phop-independently-regulate-the-expression-of-grhd1-a-novel-gene-required-for-salmonella-typhimurium-invasion-of-host-cells
#10
María M Banda, Carolina López, Rubiceli Manzo, Gadea Rico-Pérez, Pablo García, Roberto Rosales-Reyes, Miguel A De la Cruz, Fernando C Soncini, Francisco García-Del Portillo, Víctor H Bustamante
When Salmonella is grown in the nutrient-rich lysogeny broth (LB), the AraC-like transcriptional regulator HilD positively controls the expression of genes required for Salmonella invasion of host cells, such as the Salmonella pathogenicity island 1 (SPI-1) genes. However, in minimal media, the two-component system PhoP/Q activates the expression of genes necessary for Salmonella replication inside host cells, such as the SPI-2 genes. Recently, we found that the SL1344_1872 hypothetical gene, located in a S...
March 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29535187/the-hcp-like-protein-hile-inhibits-homodimerization-and-dna-binding-of-the-virulence-associated-transcriptional-regulator-hild-in-salmonella
#11
Claudia C Paredes-Amaya, Gilberto Valdés-García, Víctor R Juárez-González, Enrique Rudiño-Piñera, Víctor H Bustamante
HilD is an AraC-like transcriptional regulator that plays a central role in Salmonella virulence. HilD controls the expression of the genes within the Salmonella pathogenicity island 1 (SPI-1) and of several genes located outside SPI-1, which are mainly required for Salmonella invasion of host cells. The expression, amount and activity of HilD are tightly controlled by the activities of several factors. The HilE protein represses the expression of the SPI-1 genes through its interaction with HilD; however, the mechanism by which HilE affects HilD is unknown...
March 13, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29523850/risk-of-nontyphoidal-salmonella-bacteraemia-in-african-children-is-modified-by-stat4
#12
James J Gilchrist, Anna Rautanen, Benjamin P Fairfax, Tara C Mills, Vivek Naranbhai, Holly Trochet, Matti Pirinen, Esther Muthumbi, Salim Mwarumba, Patricia Njuguna, Neema Mturi, Chisomo L Msefula, Esther N Gondwe, Jenny M MacLennan, Stephen J Chapman, Malcolm E Molyneux, Julian C Knight, Chris C A Spencer, Thomas N Williams, Calman A MacLennan, J Anthony G Scott, Adrian V S Hill
Nontyphoidal Salmonella (NTS) is a major cause of bacteraemia in Africa. The disease typically affects HIV-infected individuals and young children, causing substantial morbidity and mortality. Here we present a genome-wide association study (180 cases, 2677 controls) and replication analysis of NTS bacteraemia in Kenyan and Malawian children. We identify a locus in STAT4, rs13390936, associated with NTS bacteraemia. rs13390936 is a context-specific expression quantitative trait locus for STAT4 RNA expression, and individuals carrying the NTS-risk genotype demonstrate decreased interferon-γ (IFNγ) production in stimulated natural killer cells, and decreased circulating IFNγ concentrations during acute NTS bacteraemia...
March 9, 2018: Nature Communications
https://www.readbyqxmd.com/read/29522566/minimal-spi1-t3ss-effector-requirement-for-salmonella-enterocyte-invasion-and-intracellular-proliferation-in-vivo
#13
Kaiyi Zhang, Ambre Riba, Monika Nietschke, Natalia Torow, Urska Repnik, Andreas Pütz, Marcus Fulde, Aline Dupont, Michael Hensel, Mathias Hornef
Effector molecules translocated by the Salmonella pathogenicity island (SPI)1-encoded type 3 secretion system (T3SS) critically contribute to the pathogenesis of human Salmonella infection. They facilitate internalization by non-phagocytic enterocytes rendering the intestinal epithelium an entry site for infection. Their function in vivo has remained ill-defined due to the lack of a suitable animal model that allows visualization of intraepithelial Salmonella. Here, we took advantage of our novel neonatal mouse model and analyzed various bacterial mutants and reporter strains as well as gene deficient mice...
March 9, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29515658/chlortetracycline-and-florfenicol-induce-expression-of-genes-associated-with-pathogenicity-in-multidrug-resistant-salmonella-enterica-serovar-typhimurium
#14
Devin B Holman, Shawn M D Bearson, Bradley L Bearson, Brian W Brunelle
Background: Multidrug-resistant (MDR) Salmonella enterica serovar Typhimurium ( S . Typhimurium) is a serious public health threat as infections caused by these strains are more difficult and expensive to treat. Livestock serve as a reservoir for MDR Salmonella , and the antibiotics chlortetracycline and florfenicol are frequently administrated to food-producing animals to treat and prevent various diseases. Therefore, we evaluated the response of MDR S . Typhimurium after exposure to these two antibiotics...
2018: Gut Pathogens
https://www.readbyqxmd.com/read/29512849/phenotypic-and-virulence-traits-of-e-coli-and-salmonella-strains-isolated-from-vegetables-and-fruits-from-india
#15
Preeti Verma, Vijay Veer Saharan, Surendra Nimesh, Arvind Pratap Singh
AIMS: The present study was designed to assess the phenotypic traits and virulence determinants of vegetables/fruits-origin E. coli and Salmonella strains. METHODS AND RESULTS: A total of 520 fresh vegetables/fruits samples were analyzed for the presence of E. coli, including Shiga-toxin producing E. coli (STEC), and Salmonella. The vegetables/fruits-origin E. coli and Salmonella strains were further assessed for antimicrobial resistance, biofilm formation, extracellular matrix production, and in-vitro invasion/intracellular survivability assays...
March 7, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29511082/igg-responses-to-porins-and-lipopolysaccharide-within-an-outer-membrane-based-vaccine-against-nontyphoidal-salmonella-develop-at-discordant-rates
#16
Anna E Schager, C Coral Dominguez-Medina, Francesca Necchi, Francesca Micoli, Yun Shan Goh, Margaret Goodall, Adriana Flores-Langarica, Saeeda Bobat, Charlotte N L Cook, Melissa Arcuri, Arianna Marini, Lloyd D W King, Faye C Morris, Graham Anderson, Kai-Michael Toellner, Ian R Henderson, Constantino López-Macías, Calman A MacLennan, Adam F Cunningham
Antibodies acquired after vaccination or natural infection with Gram-negative bacteria, such as invasive Salmonella enterica serovar Typhimurium, can protect against disease. Immunization with naturally shed outer membrane vesicles from Gram-negative bacteria is being studied for its potential to protect against many infections, since antigens within vesicles maintain their natural conformation and orientation. Shedding can be enhanced through genetic modification, and the resulting particles, generalized modules for membrane antigens (GMMA), not only offer potential as vaccines but also can facilitate the study of B-cell responses to bacterial antigens...
March 6, 2018: MBio
https://www.readbyqxmd.com/read/29497603/high-throughput-quantification-of-bacterial-cell-interactions-using-virtual-colony-counts
#17
Stefanie Hoffmann, Steffi Walter, Anne-Kathrin Blume, Stephan Fuchs, Christiane Schmidt, Annemarie Scholz, Roman G Gerlach
The quantification of bacteria in cell culture infection models is of paramount importance for the characterization of host-pathogen interactions and pathogenicity factors involved. The standard to enumerate bacteria in these assays is plating of a dilution series on solid agar and counting of the resulting colony forming units (CFU). In contrast, the virtual colony count (VCC) method is a high-throughput compatible alternative with minimized manual input. Based on the recording of quantitative growth kinetics, VCC relates the time to reach a given absorbance threshold to the initial cell count using a series of calibration curves...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29473020/functional-analysis-of-the-chaperone-usher-fimbrial-gene-clusters-of-salmonella-enterica-serovar-typhi
#18
Karine Dufresne, Julie Saulnier-Bellemare, France Daigle
The human-specific pathogen Salmonella enterica serovar Typhi causes typhoid, a major public health issue in developing countries. Several aspects of its pathogenesis are still poorly understood. S . Typhi possesses 14 fimbrial gene clusters including 12 chaperone-usher fimbriae ( stg, sth, bcf , fim, saf , sef , sta, stb, stc, std, ste , and tcf ). These fimbriae are weakly expressed in laboratory conditions and only a few are actually characterized. In this study, expression of all S . Typhi chaperone-usher fimbriae and their potential roles in pathogenesis such as interaction with host cells, motility, or biofilm formation were assessed...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29458091/role-of-the-ssek1-gene-in-the-pathogenicity-of-salmonella-enterica-serovar-enteritidis-in-vitro-and-in-vivo
#19
Yadong Yang, Chuan Yu, Ke Ding, Chunjie Zhang, Chengshui Liao, Yanyan Jia, Jing Li, Xiangchao Cheng
Salmonella enteritidis is a common food-borne pathogen associated with consumption of contaminated poultry meat and eggs, which frequently causes gastroenteritis in humans. Salmonella secreted effector K1 (SseK1), as a translocated and secreted protein has been identified to be essential for the virulence of Salmonella typhimurium in host cells. However, the role of the sseK1 gene in the pathogenicity of S. enteritidis remain unclear. In this study, a sseK1 deletion mutant of S. enteritidis was constructed and its biological characteristics were examined...
February 16, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29456197/clinical-usefulness-and-accuracy-of-polymerase-chain-reaction-in-the-detection-of-bacterial-meningitis-agents-in-pediatric-cerebrospinal-fluid
#20
M Nour, A Alaidarous
Bacterial meningitis poses enormous healthcare challenges due to a high mortality, morbidity and sequelae. Neisseria (N.) meningitidis, Haemophilus (H.) influenzae, Streptococcus (S.) pneumoniae and S. agalactiae remain among the most prevalent infectious agents that cause bacterial meningitis in children. The objective of this study was the simultaneous detection of these pathogens in suspected cerebrospinal fluid (CSF) by using multiplex polymerase chain reaction (mPCR) and compare PCR results with standard diagnostics currently used in clinical practice...
February 15, 2018: Current Research in Translational Medicine
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