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salmonella bone infection

Mohammad Charehsaz, Rengin Reis, Sinem Helvacioglu, Hande Sipahi, Etil Guzelmeric, Ebru Turkoz Acar, Gamze Cicek, Erdem Yesilada, Ahmet Aydin
ETHNOPHARMACOLOGICAL RELEVANCE: Styrax liquidus is a resinous exudate (balsam) obtained from the wounded trunk of the Liquidambar orientalis Mill. (Hamamelidaceae). Styrax has been used for treatment of various ailments in Turkish folk medicine such as skin problems, peptic ulcers, nocturnal enuresis, parasitic infections, antiseptic or as expectorant. AIM OF STUDY: In spite of frequent use of styrax in Turkish folk medicine as well as once as a stabilizer in perfumery industry, negative reports have been noticed by the international authority for restriction its use based on some limited evidences from an in vitro study...
October 10, 2016: Journal of Ethnopharmacology
Muthu Gopal, Sathishkumar Elumalai, Suresh Arumugam, Vishnuprabu Durairajpandian, Munirajan Arasambattu Kannan, Esthermary Selvam, Srivani Seetharaman
INTRODUCTION: Typhoid fever is endemic in India and other developing countries, causing major public health problems with high morbidity and mortality. The resistance of Salmonella enterica serovar Typhi (S. Typhi) towards commonly prescribed antimicrobials is increasing in developing countries. However, there have been several reports of the therapeutic failure of fluoroquinolones in patients with Salmonella infection. Resistance to quinolones/ fluoroquinolones commonly arises due to target site mutation...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
Elien Peeters, Geert Hooyberghs, Stijn Robijns, Kai Waldrant, Ami De Weerdt, Nicolas Delattin, Veerle Liebens, Soňa Kucharíková, Hélène Tournu, Natalie Verstraeten, Barbara Dovgan, Lenart Girandon, Mirjam Fröhlich, Katrijn De Brucker, Patrick Van Dijck, Jan Michiels, Bruno P A Cammue, Karin Thevissen, Jozef Vanderleyden, Erik Van der Eycken, Hans P Steenackers
Previously, we have synthesized several series of compounds, based on the 5-aryl-2-aminoimidazole scaffold, that show a preventive activity against biofilm formation of Salmonella Typhimurium and Pseudomonas aeruginosa Here, we further studied the activity spectrum of a number of the most active N1- and 2N-substituted compounds against a broad panel of monospecies and mixed species biofilms of bacteria and fungi. A N1-substituted compound showed very strong anti-biofilm activity against Gram-negatives and Gram-positives and against the fungus Candida albicans, but was previously shown to be toxic against various eukaryotic cell lines...
August 22, 2016: Antimicrobial Agents and Chemotherapy
Rafael Antonio Casarin Penha Filho, Silvia Juliana Acelas Diaz, Tiago da Silva Medina, Yung-Fu Chang, João Santana da Silva, Angelo Berchieri
Salmonella enterica serovar Gallinarum biovar Gallinarum (SG) causes fowl typhoid in chickens, a septicemic infection which results in high mortality rates. This disease causes high economic impact to the poultry industry worldwide because of the mortality or elimination of positive flocks to control bacterial dissemination. Live vaccines are used in the fields, however the characterization of immune mechanisms important for protection are being studied to improve the efficacy of vaccination schemes. In this study, we evaluated the immune response in brown layer-hens, vaccinated or not, during the most critical period of infection...
August 2016: Research in Veterinary Science
Qian-Qian Lei, Gui-Qiu Hu, Wei Chen, Shui-Xing Yu, Shuai Qi, Chong-Tao Du, Jing-Min Gu, Tong-Jun Lin, Yong-Jun Yang
OBJECTIVE: RCAN1 (regulator of calcineurin 1) has been shown to be involved in various physiological and pathological processes. However, the biological implications of RCAN1 during gastrointestinal tract infection remain unclear. In this study, we tried to determine the role of RCAN1 in acute Salmonella infectious colitis. METHODS: Wild type and RCAN1-deficient mice or macrophages were used to characterize the impacts of RCAN1 on intestinal inflammation, inflammatory cytokines production, animal survival, and pathogen clearance following Salmonella challenge...
September 2016: Molecular Immunology
Masaki Yugami, Haruki Odagiri, Motoyoshi Endo, Hiroyasu Tsutsuki, Shigemoto Fujii, Tsuyoshi Kadomatsu, Tetsuro Masuda, Keishi Miyata, Kazutoyo Terada, Hironori Tanoue, Hitoshi Ito, Jun Morinaga, Haruki Horiguchi, Taichi Sugizaki, Takaaki Akaike, Tomomi Gotoh, Toshiyuki Takai, Tomohiro Sawa, Hiroshi Mizuta, Yuichi Oike
Macrophages play crucial roles in combatting infectious disease by promoting inflammation and phagocytosis. Angiopoietin-like protein 2 (ANGPTL2) is a secreted factor that induces tissue inflammation by attracting and activating macrophages to produce inflammatory cytokines in chronic inflammation-associated diseases such as obesity-associated metabolic syndrome, atherosclerosis, and rheumatoid arthritis. Here, we asked whether and how ANGPTL2 activates macrophages in the innate immune response. ANGPTL2 was predominantly expressed in proinflammatory mouse bone marrow-derived differentiated macrophages (GM-BMMs) following GM-CSF treatment relative to anti-inflammatory cells (M-BMMs) established by M-CSF treatment...
September 2, 2016: Journal of Biological Chemistry
Hidekazu Niwa, Seiji Hobo, Yuta Kinoshita, Masanori Muranaka, Akihiro Ochi, Takanori Ueno, Kazuomi Oku, Kazuhisa Hariu, Yoshinari Katayama
Salmonella enterica subsp. enterica serovar Abortusequi is a pathogen restricted to horses. Our investigation targeted 4 draft horses (9-10 months old) kept on a Japanese farm that had suffered an outbreak of S. Abortusequi abortion. The 4 horses were suspected to be carriers of the bacterium owing to their high agglutination titers (≥1:2,560) in tube agglutination testing. The owners' on-farm observations confirmed that the horses had no apparent abnormalities, and S. Abortusequi was not isolated from their blood, rectal swabs, or sternal bone marrow fluid at antemortem investigation...
July 2016: Journal of Veterinary Diagnostic Investigation
Yan Qu, Shahram Misaghi, Kim Newton, Allie Maltzman, Anita Izrael-Tomasevic, David Arnott, Vishva M Dixit
NLRC4 and NLRP3, of the NOD-like receptor (NLR) family of intracellular proteins, are expressed in innate immune cells and are thought to nucleate distinct inflammasome complexes that promote caspase-1 activation, secretion of the proinflammatory cytokines IL-1β and IL-18, and a form of cell death termed pyroptosis. We show that NLRP3 associates with NLRC4 in macrophages infected with Salmonella typhimurium or transfected with flagellin. The significance of the interaction between the NLRC4 NACHT domain and NLRP3 was revealed when Nlrc4(S533A/S533A) bone marrow-derived macrophages (BMDMs) expressing phosphorylation site mutant NLRC4 S533A had only a mild defect in caspase-1 activation when compared with NLRC4-deficient BMDMs...
May 30, 2016: Journal of Experimental Medicine
Yue Zhao, Jianjin Shi, Xuyan Shi, Yupeng Wang, Fengchao Wang, Feng Shao
Biochemical studies suggest that the NAIP family of NLR proteins are cytosolic innate receptors that directly recognize bacterial ligands and trigger NLRC4 inflammasome activation. In this study, we generated Naip5(-/-), Naip1(-/-), and Naip2(-/-) mice and showed that bone marrow macrophages derived from these knockout mice are specifically deficient in detecting bacterial flagellin, the type III secretion system needle, and the rod protein, respectively. Naip1(-/-), Naip2(-/-), and Naip5(-/-) mice also resist lethal inflammasome activation by the corresponding ligand...
May 2, 2016: Journal of Experimental Medicine
Shashank Purwar, Sharada C Metgud, Manohar B Mutnal, Mahantesh B Nagamoti, Chidanand S Patil
BACKGROUND: The culture has always been the gold standard test for diagnosis of human brucellosis but the conventional Brucella diagnostic tests viz. serology and culture are often beset with poor specificity & sensitivity respectively. The culture positivity rates for Brucella vary from 92% for bone marrow to 10% for non-blood samples and also dependent on the type of sample. The primary immune-determinant for Brucella species is the cell wall surface lipopolysaccharide, which is antigenically similar to other gram-negative rods...
February 2016: Journal of Clinical and Diagnostic Research: JCDR
Laura E Sanman, Yu Qian, Nicholas A Eisele, Tessie M Ng, Wouter A van der Linden, Denise M Monack, Eranthie Weerapana, Matthew Bogyo
When innate immune cells such as macrophages are challenged with environmental stresses or infection by pathogens, they trigger the rapid assembly of multi-protein complexes called inflammasomes that are responsible for initiating pro-inflammatory responses and a form of cell death termed pyroptosis. We describe here the identification of an intracellular trigger of NLRP3-mediated inflammatory signaling, IL-1β production and pyroptosis in primed murine bone marrow-derived macrophages that is mediated by the disruption of glycolytic flux...
2016: ELife
Dirk Roos
INTRODUCTION: Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by recurrent, life-threatening bacterial and fungal infections of the skin, the airways, the lymph nodes, the liver, the brain and the bones. Frequently found pathogens are Staphylococcus aureus, Aspergillus species, Klebsiella species, Burkholderia cepacia, Serratia marcescens and Salmonella species. SOURCES OF DATA: CGD is a rare (∼1:250 000 individuals) disease caused by mutations in any one of the five components of the NADPH oxidase in phagocytic leucocytes...
June 2016: British Medical Bulletin
Jean-Marie Berthelot, Jean Sibilia
Tropheryma Whipplei can induce rheumatism mimicking SpA or RA, but even more rampant bacterial/viral infections in epiphyseal bones could also contribute to the onset of RA and SpA. Indeed, as bone marrow stem cell niches are enriched in Tregs and myeloid derived suppressor cells, these areas are favourable for the persistence of quiescent viruses and/or dormant bacteria. This review focuses on the possibility that such silent infections of bone marrow stem cell niches might contribute to the pathogenesis of SpA and RA, at least during their onset...
March 2016: Clinical and Experimental Rheumatology
Nitin Machindra Kamble, Chetan Vilas Jawale, John Hwa Lee
Salmonella enterica serovar Gallinarum (SG) is a Gram-negative intracellular host-adapted pathogen that causes fowl typhoid. Attenuated strains of SG are proven and widely used vaccine candidates because of advantages like induction of strong humoral and cell-mediated immune responses. In the present study, we investigated the interaction of chicken bone marrow-derived dendritic cells (chBM-DCs) with an attenuated SG (JOL1355) strain that secretes a heat-labile enterotoxin B subunit protein previously shown to successfully vaccinate chickens...
2016: Avian Pathology: Journal of the W.V.P.A
Karolina Slowicka, Lars Vereecke, Conor Mc Guire, Mozes Sze, Jonathan Maelfait, Annasaheb Kolpe, Xavier Saelens, Rudi Beyaert, Geert van Loo
Optineurin (OPTN) is an evolutionary conserved and ubiquitously expressed ubiquitin-binding protein that has been implicated in glaucoma, Paget bone disease, amyotrophic lateral sclerosis, and other neurodegenerative diseases. From in vitro studies, OPTN was shown to suppress TNF-induced NF-κB signaling and virus-induced IRF signaling, and was identified as an autophagy receptor required for the clearance of cytosolic Salmonella upon infection. To assess the in vivo functions of OPTN in inflammation and infection, we generated OPTN-deficient mice...
April 2016: European Journal of Immunology
Daniel A Powell, Lydia M Roberts, Hannah E Ledvina, Gregory D Sempowski, Roy Curtiss, Jeffrey A Frelinger
Upon bacterial infection the host cells generate a wide variety of cytokines. Genetic attenuation of bacterial physiological pathogens can be accomplished not only by disruption of normal bacterial processes, but also by the loss of the ability to redirect the host immune system. We examined nine attenuated Salmonella Typhimurium mutants for their ability to replicate as well as the cytokines produced after infection of Bone Marrow Derived Macrophages (BMDM). Infection of BMDM with attenuated Salmonella mutants led to host cytokine patterns distinct from those that followed WT infection...
January 2016: Cellular Immunology
Claudia Elera-Fitzcarrald, José L Alfaro-Lozano, César A Pastor-Asurza
We report the case of a 35-year-old male, who was diagnosed with systemic lupus erythematosus (SLE) in 2010 based on the presence of articular, serous, renal, immune, and hematologic involvement. He also had secondary antiphospholipid syndrome (APS). He was treated with prednisone 10 mg per day, hydroxychloroquine 200 mg per day, methotrexate 12.5 mg per week, leflunomide 20 mg per day, and oral anticoagulation previous to the present event. He presented to emergency room with a 7 day disease duration characterized by pain in the left thigh, which increased with physical activity, resulting in claudication; he also had malaise and fever...
December 2015: Clinical Rheumatology
Thuy Xuan Phan, Vu Hong Nguyen, Mai Thi-Quynh Duong, Yeongjin Hong, Hyon E Choy, Jung-Joon Min
Escherichia coli and attenuated Salmonella both naturally accumulate in a tumor mass, yet have distinct therapeutic efficacy: the E. coli K-12 strain (MG1655) cannot induce as significant a tumor suppression as attenuated Salmonella typhimurium, despite similar levels of accumulation in the tumor. To elucidate the mechanism of the robust antitumor effect of S. typhimurium, the cytokine profiles elicited by bacterial colonization in tumors were analyzed. C57BL/6 mice bearing MC38 tumors were injected with Salmonella or MG1655 in the tail vein...
November 2015: Microbiology and Immunology
Jessica P Leyva-Rangel, Maria de Los Angeles Hernández-Cueto, Carlos-Samuel Galan-Enriquez, Marcela López-Medina, Vianney Ortiz-Navarrete
Salmonella typhimurium invades the spleen, liver, and peripheral lymph nodes and has recently been detected in the bone marrow and thymus, resulting in a reduced thymic size and a decline in the total number of thymic cells. A specific deletion of the double-positive cell subset has been characterized, yet the export of mature T cells to the periphery remains normal. We analyzed Salmonella pathogenesis regarding thymic structure and the T-cell maturation process. We demonstrate that, despite alterations in the thymic structure, T-cell development is maintained during Salmonella infection, allowing the selection of single-positive T-cell clones expressing particular T-cell receptor beta chains (TCR-Vβ)...
September 2015: Immunity, Inflammation and Disease
Marcela López-Medina, Ismael Carrillo-Martín, Jessica Leyva-Rangel, Celia Alpuche-Aranda, Vianney Ortiz-Navarrete
We have shown that Salmonella remains for a long period of time within B cells, plasma cells, and bone marrow B cell precursors, which might allow persistence and dissemination of infection. Nonetheless, how infected cells evade CD8 T cell response has not been characterized. Evidence indicates that some pathogens exploit the PD-1: PD-L (PD-L1 and PD-L2) interaction to inhibit CD8 T cells response to contribute the chronicity of the infection. To determine whether the PD-1: PD-L axis plays a role during Salmonella infection; we evaluated PD-1 expression in antigen-specific CD8 T cells and PD-1 ligands in Salmonella-infected cells...
December 2015: Immunobiology
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