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https://www.readbyqxmd.com/read/29222990/rapid-and-irreversible-sorption-behavior-of-7be-assessed-to-evaluate-its-use-as-a-catchment-sediment-tracer
#1
N Ryken, B Al-Barri, W Blake, A Taylor, F M G Tack, E Van Ranst, S Bodé, P Boeckx, A Verdoodt
Beryllium-7 (7Be) has been used as a sediment tracer to evaluate soil redistribution rates at hillslopes and as a tool to estimate sediment residence time in river systems. A key assumption for the use of 7Be as a sediment tracer is the rapid and irreversible sorption of 7Be upon contact with the soil particles. However, recent studies have raised questions about the validity of these assumptions. Seven soil types were selected to assess the adsorption rate of 7Be on the soil particles, subsequently an extraction experiment was performed to assess the rate of desorption...
December 6, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29222187/mutant-idh1r132h-induces-transcriptional-and-epigenomic-reprogramming
#2
(no author information available yet)
A fraction of the chromatin state and DNA methylation changes induced by IDH1R132H are irreversible.
December 8, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/29221796/synthesis-and-antibacterial-activity-of-new-peptides-from-alfalfa-rubisco-protein-hydrolysates-and-mode-of-action-via-a-membrane-damage-mechanism-against-listeria-innocua
#3
Sabrine Kobbi, Naima Nedjar, Nourdine Chihib, Rafik Balti, Mickael Chevalier, Amandine Silvain, Semia Chaabouni, Pascal Dhulster, Ali Bougatef
In this work we evaluated the mode of action of six new synthesized peptides (Met-Asp-Asn; Glu-leu-Ala-Ala-Ala-Cys; Leu-Arg-Asp-Asp-Phe; Gly-Asn-Ala-Pro-Gly-Ala-Val-Ala; Ala-Leu-Arg-Met-Ser-Gly and Arg-Asp-Arg-Phe-Leu), previously identified, from the most active peptide fractions of RuBisCO peptic hydrolysate against Listeria innocua via a membrane damage mechanism. Antibacterial effect and the minimum inhibitory concentrations (MIC) of these peptides were evaluated against six strains and their hemolytic activities towards bovine erythrocytes were determined...
December 5, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29221730/ablation-of-transcription-factor-irf4-promotes-transplant-acceptance-by-driving-allogenic-cd4-t-cell-dysfunction
#4
Jie Wu, Hedong Zhang, Xiaomin Shi, Xiang Xiao, Yihui Fan, Laurie J Minze, Jin Wang, Rafik M Ghobrial, Jiahong Xia, Roger Sciammas, Xian C Li, Wenhao Chen
CD4+ T cells orchestrate immune responses and destruction of allogeneic organ transplants, but how this process is regulated on a transcriptional level remains unclear. Here, we demonstrated that interferon regulatory factor 4 (IRF4) was a key transcriptional determinant controlling T cell responses during transplantation. IRF4 deletion in mice resulted in progressive establishment of CD4+ T cell dysfunction and long-term allograft survival. Mechanistically, IRF4 repressed PD-1, Helios, and other molecules associated with T cell dysfunction...
December 4, 2017: Immunity
https://www.readbyqxmd.com/read/29221159/melatonin-suppresses-fibrotic-responses-induced-by-cigarette-smoke-via-downregulation-of-tgf-%C3%AE-1
#5
Na-Rae Shin, Ji-Won Park, In-Chul Lee, Je-Won Ko, Sung-Hyeuk Park, Joong-Sun Kim, Jong-Choon Kim, Kyung-Seop Ahn, In-Sik Shin
Cigarette smoke (CS) is the most important risk factor in the development of chronic obstructive pulmonary disease (COPD). Pulmonary fibrosis is an irreversible response and important feature of COPD. In this study, we investigated the effects of melatonin on fibrotic response in development of COPD using a CS and lipopolysaccharide (LPS) induced COPD model and cigarette smoke condensate (CSC)-stimulated NCI-H292 cells, a human mucoepidermoid cell line. Mice were exposed to CS for 1 h per day (8 cigarettes per day) from day 1 to day 7 and were treated intranasally with LPS on day 4...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29220060/upper-limb-ischaemia-a-south-african-single-centre-experience
#6
Tinus du Toit, Kathryn Manning, Nadraj G Naidoo
OBJECTIVE: The aims of this study were to report on our experience with upper limb ischaemia (ULI), to define the pattern and distribution of disease, describe key demographic features and report on conventional clinical outcomes. METHODS: This was a single-centre, retrospective, descriptive study. All patients (n = 64) who underwent a surgical intervention for ULI over a 12-year study period were included. Findings were analysed and compared with the current literature...
December 8, 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29220055/on-demand-acoustic-droplet-splitting-and-steering-in-a-disposable-microfluidic-chip
#7
Jinsoo Park, Jin Ho Jung, Kwangseok Park, Ghulam Destgeer, Husnain Ahmed, Raheel Ahmad, Hyung Jin Sung
On-chip droplet splitting is one of the fundamental droplet-based microfluidic unit operations to control droplet volume after production and increase operational capability, flexibility, and throughput. Various droplet splitting methods have been proposed, and among them the acoustic droplet splitting method is promising because of its label-free operation without any physical or thermal damage to droplets. Previous acoustic droplet splitting methods faced several limitations: first, they employed a cross-type acoustofluidic device that precluded multichannel droplet splitting; second, they required irreversible bonding between a piezoelectric substrate and a microfluidic chip, such that the fluidic chip was not replaceable...
December 8, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/29220048/photokinetic-study-on-remarkable-excimer-phosphorescence-from-heteroleptic-cyclometalated-platinum-ii-complexes-bearing-a-benzoylated-2-phenylpyridinate-ligand
#8
Naoki Okamura, Takeshi Maeda, Hideki Fujiwara, Anjaly Soman, K N Narayanan Unni, Ayyappanpillai Ajayaghosh, Shigeyuki Yagi
Novel heteroleptic cyclometalated platinum(ii) complexes consisting of 5'-benzoylated 2-phenylpyridinate (ppy) cyclometalated and acetylacetonate ancillary ligands were synthesized, and their photoluminescence (PL) properties were investigated. The 5'-benzoylated complex without any other substituents exhibited phosphorescence-based monomer emission at 479 nm in dichloromethane (10 μM, rt) with a PL quantum yield of 0.28. On the other hand, in poly(methyl methacrylate) (PMMA) film, remarkable excimer emission additionally emerged at ca...
December 8, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29219830/a-rare-case-of-waterhouse-friderichsen-syndrome-during-primary-varicella-zoster-infection
#9
A F N Heitz, H M A Hofstee, L B S Gelinck, J B Puylaert
Primary Varicella zoster virus infection in adults is associated with a higher risk of complications when compared with the benign disease course of primary infection during childhood. We present a rare complication of adult primary Varicella zoster in the form of acute, irreversible adrenal insufficiency due to bilateral adrenal haemorrhage, which is also known as the WaterhouseFriderichsensyndrome.
October 2017: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29219117/prediction-of-radiation-necrosis-in-a-rodent-model-using-magnetic-resonance-imaging-apparent-transverse-relaxation-r-sub-2-sub-sup-sup
#10
Jean-Guy Belliveau, Michael D Jensen, James M P Stewart, Igor Solovey, Martyn L Klassen, Glenn S Bauman, Ravi S Menon
Radiation necrosis remains an irreversible long-term side-effect following radiotherapy to the brain. The ability to predict areas that could ultimately develop into necrosis could lead to prevention and management of radiation necrosis. Materials and Methods: Fischer 344 rats were irradiated using two platforms (micro-CT irradiator and x-RAD 225 IGRT) with radiation up to 30 Gy for the micro-CT and 40 Gy for the xRAD-224 to half the brain. Animals were subsequently imaged using a 9.4T MRI scanner every 2-4 weeks for up to 28 weeks using a 7-echo gradient echo sequence...
December 8, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29219049/role-of-mitochondrial-mechanism-in-chemotherapy-induced-peripheral-neuropathy
#11
Mohammad Waseem, Pooja Kaushik, Heena Tabassum, Suhel Parvez
BACKGROUND: Even though chemotherapeutic regimens shows considerable importance, it may cause progressive, continuing and sometimes irreversible peripheral neuropathy. Chemotherapy induced peripheral neuropathy (CIPN) comprises of sensory abnormalities that are most distress issues. The mechanism associated with CIPN pathogenesis is not completely revealed and is treatment is still questionable. The purpose of this review was to investigate the role of mitochondria in CIPN. METHODS: This review is literature based that describes the mitochondrial mechanism underlying CIPN and the neuropathic complications associated with different antineoplastic agents...
December 7, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/29219003/the-futile-case-of-the-aging-ovary-is-it-mission-impossible-a-focused-review
#12
S Rasool, D Shah
Despite immense and impressive progress in the field of reproductive medicine, little has been achieved in terms of replenishing aged ovaries and improving their reproductive outcome. Age causes irreversible damage to human eggs in terms of quantity as well as quality. Nature probably designed women to reproduce best in their twenties and thirties. However, due to social, personal, career, educational and financial pressures, women delay pregnancies until their late thirties, by which time the chance of becoming pregnant is compromised by low fecundity rates and an increased risk of miscarriage...
December 8, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29218434/inhibition-of-gsk-3beta-signaling-pathway-rescues-ketamine-induced-neurotoxicity-in-neural-stem-cell-derived-neurons
#13
Jingjing Zhang, Changlei Cui, Yanhui Li, Haiyang Xu
Clinical application of anesthetic reagent, ketamine (Keta), may induce irreversible neurotoxicity in central nervous system. In this work, we utilized an in vitro model of neural stem cells-derived neurons (nSCNs) to evaluate the role of GSK-3 signaling pathway in Keta-induced neurotoxicity. Embryonic mouse-brain neural stem cells were differentiated into neurons in vitro. Keta (50 μM)-induced neurotoxicity in cultured nSCNs was monitored by apoptosis, immunohistochemical and western blot assays, respectively...
December 7, 2017: Neuromolecular Medicine
https://www.readbyqxmd.com/read/29218326/study-protocol-a-multi-centre-double-blind-randomised-placebo-controlled-parallel-group-phase-ii-trial-ridd-to-determine-the-efficacy-of-intra-nodular-injection-of-anti-tnf-to-control-disease-progression-in-early-dupuytren-s-disease-with-an-embedded-dose-response
#14
Jagdeep Nanchahal, Catherine Ball, Jennifer Swettenham, Susan Dutton, Vicki Barber, Joanna Black, Bethan Copsey, Melina Dritsaki, Peter Taylor, Alastair Gray, Marc Feldmann, Sarah Lamb
Dupuytren's disease is a common fibrotic condition of the hand affecting 4% of the population and causes the fingers to curl irreversibly into the palm. It has a strong familial tendency, there is no approved treatment for early stage disease, and patients with established digital contractures are most commonly treated by surgery. This is associated with prolonged recovery, and less invasive techniques have high recurrence rates.The myofibroblasts, the cells responsible for the excessive matrix deposition and contraction, are aggregated in nodules...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/29218300/the-dual-role-of-cellular-senescence-in-developing-tumors-and-their-response-to-cancer-therapy
#15
REVIEW
Markus Schosserer, Johannes Grillari, Michael Breitenbach
Cellular senescence describes an irreversible growth arrest characterized by distinct morphology, gene expression pattern, and secretory phenotype. The final or intermediate stages of senescence can be reached by different genetic mechanisms and in answer to different external and internal stresses. It has been maintained in the literature but never proven by clearcut experiments that the induction of senescence serves the evolutionary purpose of protecting the individual from development and growth of cancers...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29217386/early-worsening-of-diabetic-retinopathy-after-rapid-improvement-of-blood-glucose-control-in-patients-with-diabetes
#16
REVIEW
S Feldman-Billard, É Larger, P Massin
AIM: To review the frequency, importance of and risk factors for "early worsening of diabetic retinopathy" (EWDR) after rapid improvement of blood glucose in patients with diabetes. METHODS: This was a systematic review of key references (PubMed 1980-2016) and the current international recommendations for the above-mentioned topics. RESULTS: EWDR has been described during intensive treatment (IT) in patients with uncontrolled type 1 or 2 diabetes, and after pancreas transplantation or bariatric surgery...
November 11, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29217149/mucous-membrane-pemphigoid-with-ocular-involvement-the-clinical-phenotype-and-its-relationship-to-direct-immunofluorescence-findings
#17
Hon Shing Ong, Jane F Setterfield, Darwin C Minassian, John K Dart
PURPOSE: This study explored the validity of the First International Consensus on Mucous Membrane Pemphigoid (MMP) guidance, which recommends that clinically indistinguishable patients, who have direct immunofluorescence (DIF)-negative biopsies, be excluded from a diagnosis of MMP. Misdiagnosis, or delayed diagnosis, of MMP with ocular involvement leads to the inappropriate use of topical therapy, the standard of care for causes of cicatrising conjunctivitis other than MMP, rather than systemic immunomodulatory therapy, resulting in irreversible clinical deterioration in patients with MMP...
December 4, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29216763/upregulated-mir-29c-suppresses-silica-induced-lung-fibrosis-through-the-wnt-%C3%AE-catenin-pathway-in-mice
#18
X Wang, K Xu, X Y Yang, J Liu, Q Zeng, F S Wang
Silicosis is an irreversible lung disease resulting from long-term inhalation of occupational dust containing silicon dioxide. However, the pathogenesis of silicosis has not been clearly understood yet. Accumulating evidence suggests that miR-29 may have a significant anti-fibrotic capacity, meanwhile it may relate to Wnt/β-catenin pathway. The purpose of this study was to discuss the role of miR-29 in the progression of silicosis. A lentiviral vector was constructed, named Lv-miR-29c, which was overexpressing miR-29c...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29215716/simple-kinetic-model-of-mitochondrial-swelling-in-cardiac-cells
#19
Xavier Chapa-Dubocq, Vladimir Makarov, Sabzali Javadov
Mitochondria play an important role in both cell survival and cell death. In response to oxidative stress, they undergo opening of non-selective permeability transition pores (PTP) in the inner mitochondrial membrane. Sustained PTP opening triggers mitochondrial swelling due to increased colloidal osmotic pressure in the matrix accompanied by mitochondrial membrane depolarization and ATP hydrolysis. Mitochondrial swelling is the major factor leading to mitochondria-mediated cell death through both apoptosis and necrosis...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29215285/anomalous-rate-of-h-and-d-excited-state-proton-transfer-espt-in-h2o-d2o-mixtures-irreversible-espt-in-1-naphthol-4-sulfonate
#20
Oren Gajst, Georgi Gary Rozenman, Dan Huppert
We employed steady-state and time-resolved fluorescence techniques to study the rates of excited-state proton and deuteron transfer (ESPT) from an irreversible photoacid - 1-naphthol-4-sulfonate - to solvent mixtures of H2O and D2O. We found that the overall ESPT rate to the solvent mixture does not follow a linear relation with the H2O mole ratio. We used a chemical kinetic model to explain the deviation of the ESPT rate constant from linear behavior with H2O mole ratio. There are three water species in the H2O-D2O mixtures, H2O, D2O and HOD...
December 7, 2017: Journal of Physical Chemistry. A
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