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https://www.readbyqxmd.com/read/28654167/age-is-associated-with-asthma-phenotypes
#1
Eduardo V Ponte, Aline Lima, Paula C A Almeida, Juliana P V de Jesus, Valmar B Lima, Nicola Sichilone, Adelmir Souza-Machado, Álvaro A Cruz
BACKGROUND AND OBJECTIVE: The relationship between age and asthma phenotypes is important as population is ageing, asthma is becoming common in older ages and recently developed treatments for asthma are guided by phenotypes. The aim of this study is to evaluate whether age is associated with specific asthma phenotypes. METHODS: This is a cross-sectional study. We included subjects with asthma of varied degrees of severity. Subjects underwent spirometry, skin prick test to aeroallergens, answered the Asthma Control Questionnaire and had blood samples collected...
June 27, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28654166/lesions-in-the-splenium-of-the-corpus-callosum-on-mri-in-children-a-review
#2
Marinos Kontzialis, Bruno P Soares, Thierry A G M Huisman
A wide variety of conditions may involve the splenium of the corpus callosum on magnetic resonance imaging in children. A single cause may present with different patterns of splenial involvement, and multiple diseases may have similar imaging findings. Keeping this limitation in mind, the goal of this text is to assist in the diagnostic process of pediatric neurological diseases that are characterized by prominent involvement of the splenium of the corpus callosum on imaging. The various pathologies will be reviewed and categorized based on etiology, reversibility, and pattern of additional or associated findings...
June 27, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/28653752/the-potential-of-epimedium-koreanum-nakai-for-herb-drug-interaction
#3
Qingxiang Zhong, Ziqi Shi, Li Zhang, Rongling Zhong, Zhi Xia, Jing Wang, Hao Wu, Yutong Jiang, E Sun, Yingjie Wei, Liang Feng, Zhenhai Zhang, Dan Liu, Jie Song, Xiaobin Jia
OBJECTIVES: This study aims to investigate potential herb-drug interactions (HDI) of Epimedium koreanum Nakai. METHODS: Human liver microsomes (HLMs) were used to determine the enzyme kinetics of the major human cytochrome P450s (CYPs). Inducible potential of E. koreanum on CYP1A2, 2B6, 2C19 and 3A4 activities of human primary hepatocytes was also examined. KEY FINDINGS: Ethanol extract of E. koreanum showed direct inhibitory potency for CYP1A2 (IC50  = 121...
June 27, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28653662/cdk4-6-and-autophagy-inhibitors-synergistically-induce-senescence-in-rb-positive-cytoplasmic-cyclin-e-negative-cancers
#4
Smruthi Vijayaraghavan, Cansu Karakas, Iman Doostan, Xian Chen, Tuyen Bui, Min Yi, Akshara S Raghavendra, Yang Zhao, Sami I Bashour, Nuhad K Ibrahim, Meghan Karuturi, Jing Wang, Jeffrey D Winkler, Ravi K Amaravadi, Kelly K Hunt, Debu Tripathy, Khandan Keyomarsi
Deregulation of the cell cycle machinery is a hallmark of cancer. While CDK4/6 inhibitors are FDA approved (palbociclib) for treating advanced estrogen receptor-positive breast cancer, two major clinical challenges remain: (i) adverse events leading to therapy discontinuation and (ii) lack of reliable biomarkers. Here we report that breast cancer cells activate autophagy in response to palbociclib, and that the combination of autophagy and CDK4/6 inhibitors induces irreversible growth inhibition and senescence in vitro, and diminishes growth of cell line and patient-derived xenograft tumours in vivo...
June 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28653022/robust-reconstruction-of-time-resolved-diffraction-from-ultrafast-streak-cameras
#5
Daniel S Badali, R J Dwayne Miller
In conjunction with ultrafast diffraction, streak cameras offer an unprecedented opportunity for recording an entire molecular movie with a single probe pulse. This is an attractive alternative to conventional pump-probe experiments and opens the door to studying irreversible dynamics. However, due to the "smearing" of the diffraction pattern across the detector, the streaking technique has thus far been limited to simple mono-crystalline samples and extreme care has been taken to avoid overlapping diffraction spots...
September 2017: Structural Dynamics (Melville, N.Y.)
https://www.readbyqxmd.com/read/28652979/metastatic-intraocular-hemangiopericytoma-in-a-dog
#6
Jonathan D Pucket, Rachel A Allbaugh, Mary L Higginbotham, Amy J Rankin, Leandro Teixeira
A 10-year-old Labrador Retriever who had been undergoing therapy for a recurrent hemangiopericytoma of the right flank presented to the Kansas State University Ophthalmology service for evaluation of a painful left eye. Examination revealed secondary glaucoma and irreversible blindness of the affected eye and multifocal chorioretinal lesions in the fellow eye. Therapeutic and diagnostic enucleation of the left eye was performed and histopathologic examination demonstrated the presence of a presumed metastatic spindle cell sarcoma...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/28652574/clinical-features-of-congenital-and-developmental-cataract-in-east-china-a-five-year-retrospective-review
#7
Xiangjia Zhu, Yu Du, Wenwen He, Ting Sun, Yinglei Zhang, Ruiqi Chang, Keke Zhang, Yi Lu
Congenital/developmental cataract is a significant cause of blindness in children worldwide. Full knowledge of clinical features is essential for early diagnosis and proper treatment to prevent irreversible visual impairment. We conducted a retrospective chart review on 520 congenital/developmental cataract cases based on a five-year clinical data from Eye and ENT Hospital of Fudan University, Shanghai, China. Clinical features including age at the surgery, chief complaints, interval between initial identification of cataract-related manifestations and surgery, etc...
June 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28651984/synthesis-of-6-hydroxyaurone-analogues-and-evaluation-of-their-%C3%AE-glucosidase-inhibitory-and-glucose-consumption-promoting-activity-development-of-highly-active-5-6-disubstituted-derivatives
#8
Hua Sun, Weina Ding, Xiaotong Song, Dong Wang, Mingzhu Chen, Kaili Wang, Yazhou Zhang, Peng Yuan, Ying Ma, Runling Wang, Robert H Dodd, Yongmin Zhang, Kui Lu, Peng Yu
A series of 6-hydroxyaurones and their analogues have been synthesized and evaluated for their in vitro α-glucosidase inhibitory and glucose consumption-promoting activity. These compounds exhibited varying degrees of α-glucosidase inhibitory activity, 11 of them showing higher potency than that of the control standard acarbose (IC50=50.30μM). Surprisingly, analogues devoid of a substituent at C-2 but having an aryl group at C-5 were found to be highly active (e.g., 7f, IC50=9.88μM). Docking analysis substantiated these findings...
June 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28651978/changes-in-cerebral-oxygenation-in-preterm-infants-with-progressive-posthemorrhagic-ventricular-dilatation
#9
Michael Kochan, Jacob McPadden, William T Bass, Tushar Shah, Wendy T Brown, Gary W Tye, Turaj Vazifedan
BACKGROUND: Optimal timing of intervention in neonatal progressive posthemorrhagic hydrocephalus is often a difficult decision. Unchecked hydrocephalus can lead to irreversible brain injury through impaired perfusion, while placement of a shunt is not without long-term morbidity. The purpose of this study was to assess the use of near-infrared spectroscopy to measure changes in regional cerebral oxygen saturation as an indicator of cerebral perfusion in infants with progressive posthemorrhagic ventricular dilatation...
May 25, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28651656/operable-patent-ductus-arteriosus-even-with-differential-cyanosis-a-case-of-patent-ductus-arteriosus-and-mitral-stenosis
#10
Anunay Gupta, Shyam S Kothari
Patients with patent ductus arteriosus and significant left-to-right shunt develop Eisenmenger syndrome at an early age and are not operable after development of irreversible pulmonary artery hypertension. Patients with mitral stenosis, however, are treatable even with suprasystemic pulmonary artery pressures. A combination of these two lesions is rare. We document a patient with differential cyanosis who improved after corrective surgery of both the lesions. The importance of post-capillary pulmonary artery hypertension in shunt lesions needs to be better appreciated...
June 27, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28651650/ethics-review-of-studies-during-public-health-emergencies-the-experience-of-the-who-ethics-review-committee-during-the-ebola-virus-disease-epidemic
#11
Emilie Alirol, Annette C Kuesel, Maria Magdalena Guraiib, Vânia Dela Fuente-Núñez, Abha Saxena, Melba F Gomes
BACKGROUND: Between 2013 and 2016, West Africa experienced the largest ever outbreak of Ebola Virus Disease. In the absence of registered treatments or vaccines to control this lethal disease, the World Health Organization coordinated and supported research to expedite identification of interventions that could control the outbreak and improve future control efforts. Consequently, the World Health Organization Research Ethics Review Committee (WHO-ERC) was heavily involved in reviews and ethics discussions...
June 26, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/28651626/selective-impairments-of-alerting-and-executive-control-in-hiv-infected-patients-evidence-from-attention-network-test
#12
Yi-Quan Wang, Yang Pan, Sheng Zhu, Yong-Guang Wang, Zhi-Hua Shen, Kai Wang
BACKGROUND: Attention ability can be subdivided into three functionally independent networks, i.e., alerting network, orienting network, and executive network. Previous literature has documented that deficits in attention are a common consequence of HIV infection. However, the precise nature of deficits of attention in HIV-infected patients is poorly understood. Accordingly, the aim of the study was to identify whether the HIV-infected patients showed a specific attention network deficit or a general attentional impairment...
June 27, 2017: Behavioral and Brain Functions: BBF
https://www.readbyqxmd.com/read/28651595/identification-of-pathogenic-genes-and-upstream-regulators-in-age-related-macular-degeneration
#13
Bin Zhao, Mengya Wang, Jing Xu, Min Li, Yuhui Yu
BACKGROUND: Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in older individuals. Our study aims to identify the key genes and upstream regulators in AMD. METHODS: To screen pathogenic genes of AMD, an integrated analysis was performed by using the microarray datasets in AMD derived from the Gene Expression Omnibus (GEO) database. The functional annotation and potential pathways of differentially expressed genes (DEGs) were further discovered by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis...
June 26, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28650421/percutaneous-irreversible-electroporation-for-portal-vein-tumor-thrombus-a-case-report
#14
Weilu Chai, Guo Tian, Tianʼan Jiang
No abstract text is available yet for this article.
June 23, 2017: Ultrasound Quarterly
https://www.readbyqxmd.com/read/28650111/photochromic-dopamine-receptor-ligands-based-on-dithienylethenes-and-fulgides
#15
Daniel Lachmann, Carolin Studte, Barbara Männel, Harald Huebner, Peter Gmeiner, Burkhard König
We describe the incorporation of the well-investigated class of photochromic dithienylethenes (DTEs) and fulgides into known dopamine receptor ligands like 1,4-disubstituted aromatic and hydroxybenzoxazinone piperazines as well as aminoindanes. Subtype and functional selective photochromic ligands were obtained and characterized by NMR and UV-VIS spectroscopic measurements. The photophysical properties of the DTE based dopamine ligands revealed a high fatigue resistance for the diarylmaleimides, but the ringclosure could not be accomplished in polar solvents due to a known twisted intramolecular charge transfer (TICT)...
June 26, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28649846/modifying-emission-spectral-bandwidth-of-phosphorescent-platinum-ii-complexes-through-synthetic-control
#16
Guijie Li, Alicia Wolfe, Jason Brooks, Zhi-Qiang Zhu, Jian Li
The design, synthesis, and characterization of a series of tetradentate cyclometalated Pt(II) complexes are reported. The platinum complexes have the general structure Pt(ppz-O-CbPy-R), where a tetradentate cyclometalating ligand is consisting of ppz (3,5-dimethyl-1-phenyl-pyrazole), CbPy (carbazolylpyridine) components, and an oxygen bridging group. Variations of the R group on the pyridyl ring with various electron withdrawing and donating substituents are shown to have profound effects on the photophysical properties of Pt complexes...
June 26, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28649564/primary-ciliary-dyskinesia-an-update-on-clinical-aspects-genetics-diagnosis-and-future-treatment-strategies
#17
REVIEW
Virginia Mirra, Claudius Werner, Francesca Santamaria
Primary ciliary dyskinesia (PCD) is an orphan disease (MIM 244400), autosomal recessive inherited, characterized by motile ciliary dysfunction. The estimated prevalence of PCD is 1:10,000 to 1:20,000 live-born children, but true prevalence could be even higher. PCD is characterized by chronic upper and lower respiratory tract disease, infertility/ectopic pregnancy, and situs anomalies, that occur in ≈50% of PCD patients (Kartagener syndrome), and these may be associated with congenital heart abnormalities...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28649128/lx2343-alleviates-cognitive-impairments-in-ad-model-rats-by-inhibiting-oxidative-stress-induced-neuronal-apoptosis-and-tauopathy
#18
Xiao-Dan Guo, Guang-Long Sun, Ting-Ting Zhou, Yi-Yang Wang, Xin Xu, Xiao-Fan Shi, Zhi-Yuan Zhu, Vatcharin Rukachaisirikul, Li-Hong Hu, Xu Shen
Alzheimer's disease (AD) is a progressive neurodegenerative disease leading to the irreversible loss of brain neurons and cognitive abilities, and the vicious interplay between oxidative stress (OS) and tauopathy is believed to be one of the major players in AD development. Here, we demonstrated the capability of the small molecule N-(1,3-benzodioxol-5-yl)-2-[5-chloro-2-methoxy(phenylsulfonyl)anilino]acetamide (LX2343) to ameliorate the cognitive dysfunction of AD model rats by inhibiting OS-induced neuronal apoptosis and tauopathy...
June 26, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28648380/privileged-electrophile-sensors-a-resource-for-covalent-drug-development
#19
REVIEW
Marcus John Curtis Long, Yimon Aye
This Perspective delineates how redox signaling affects the activity of specific enzyme isoforms and how this property may be harnessed for rational drug design. Covalent drugs have resurged in recent years and several reports have extolled the general virtues of developing irreversible inhibitors. Indeed, many modern pharmaceuticals contain electrophilic appendages. Several invoke a warhead that hijacks active-site nucleophiles whereas others take advantage of spectator nucleophilic side chains that do not participate in enzymatic chemistry, but are poised to bind/react with electrophiles...
June 10, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28647770/ct-value-of-the-intestine-is-useful-predictor-for-differentiate-irreversible-ischaemic-changes-in-strangulated-ileus
#20
Atsushi Kohga, Akihiro Kawabe, Kiyoshige Yajima, Takuya Okumura, Kimihiro Yamashita, Jun Isogaki, Kenji Suzuki, Katsuaki Muramatsu
PURPOSE: To determine the differential points of strangulated ileus with and without irreversible ischaemic changes, especially on preoperative computed tomography (CT) images. METHODS: Seventy patients with strangulated ileus underwent emergency operations between January 2009 and July 2016 in our department. Of these patients, 57 met the study requirements, including 30 patients who had irreversible ischaemic changes (ischaemic group; n = 30) and 27 patients who had reversible ischaemic changes during laparotomy (non-ischaemic group; n = 27)...
June 24, 2017: Abdominal Radiology
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