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https://www.readbyqxmd.com/read/28334917/late-onset-cystic-brain-necrosis-after-radiotherapy-for-nasopharyngeal-carcinoma
#1
Wenli Fang, Beibei Gu, Xiuna Jing, Songhua Xiao, Shengnuo Fan, Wang Liao, Yuqiu Zheng, Jun Liu
Background: Cystic brain radionecrosis (CBRN) is a late-onset devastating complication after radiotherapy for head and neck neoplasms, especially for nasopharyngeal carcinoma (NPC). To our knowledge, it has scarcely been reported. Methods: We retrospectively reviewed all available medical records of NPC patients with CBRN who were treated with surgical intervention. Results: Sixteen patients were identified in this study and the mean latency of CBRN was 9...
February 24, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28334702/in-vitro-antibacterial-activity-of-7-substituted-6-fluoroquinolone-and-7-substituted-6-8-difluoroquinolone-derivatives
#2
Socorro Leyva-Ramos, Denisse de Loera, Jaime Cardoso-Ortiz
BACKGROUND: Fluoroquinolones are widely prescribed synthetic antimicrobial agents. Quinolones act by converting their targets, gyrase and topoisomerase IV, into toxic enzymes that fragment the bacterial chromosome; the irreversible DNA damage eventually causes the killing of bacteria. Thorough knowledge of the structure-activity relationship of quinolones is essential for the development of new drugs with improved activity against resistant strains. METHODS: The compounds were screened for their antibacterial activity against 4 representing strains using the Kirby-Bauer disk diffusion method...
March 24, 2017: Chemotherapy
https://www.readbyqxmd.com/read/28333092/impact-of-coagulant-and-flocculant-addition-to-an-anaerobic-dynamic-membrane-bioreactor-andmbr-treating-waste-activated-sludge
#3
Guido Kooijman, Wilton Lopes, Zhongbo Zhou, Hongxiao Guo, Merle de Kreuk, Henri Spanjers, Jules van Lier
In this work, we investigated the effects of flocculation aid (FA) addition to an anaerobic dynamic membrane bioreactor (AnDMBR) (7 L, 35 °C) treating waste-activated sludge (WAS). The experiment consisted of three distinct periods. In period 1 (day 1-86), the reactor was operated as a conventional anaerobic digester with a solids retention time (SRT) and hydraulic retention time (HRT) of 24 days. In period 2 (day 86-303), the HRT was lowered to 18 days with the application of a dynamic membrane while the SRT was kept the same...
March 23, 2017: Membranes
https://www.readbyqxmd.com/read/28333064/the-removal-of-typical-pollutants-in-secondary-effluent-by-the-combined-process-of-powdered-activated-carbon-ultrafiltration
#4
Lihua Sun, Ning He, Tianmin Yu, Xi Duan, Cuimin Feng, Yajun Zhang
This paper focused on the effects of powdered activated carbon (PAC) dosage on ultrafiltration (UF) membrane flux caused by natural organic matter (NOM). Three model foulants, humic acid (HA), bovine serum albumin (BSA) and sodium alginate (SA), were adopted to represent different NOM fractions in secondary effluent treated by the combined process of PAC-UF. Moreover, the membrane fouling resistance and fouling mechanism were also analyzed. The results indicated that the best PAC dosage for the membrane flux variation was 20 mg/L for HA and SA, and 10 mg/L for BSA...
March 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28332689/aggregation-kinetics-of-carbonyl-iron-based-magnetic-suspensions-in-2d
#5
Keshvad Shahrivar, Elizabeth Carreón-González, Jose R Morillas, Juan de Vicente
We investigate the (irreversible) two-dimensional aggregation kinetics of dilute non-Brownian magnetic suspensions in rectangular microchannels using video-microscopy, image analysis and particle-level dynamics simulations. Special emphasis is given to carbonyl iron suspensions that are of interest in the formulation of magnetorheological fluids. The results are compared to non-Brownian suspensions of magnetic latexes. We demonstrate that both suspensions follow a deterministic aggregation process. Furthermore, experimental and simulation aggregation curves can be collapsed onto a master curve when using the appropriate scaling time (∝λ(-1)ϕ2D(-2...
March 23, 2017: Soft Matter
https://www.readbyqxmd.com/read/28332677/tuneable-reversible-redox-of-cobalt-iii-carbazole-complexes
#6
Michael S Bennington, Humphrey L C Feltham, Zoë J Buxton, Nicholas G White, Sally Brooker
Four tridentate carbazole-based ligands, HL((t)Bu/H) {3,6-di(tert-butyl)-1,8-bis[5-(3-benzyl-1,2,3-triazole)]-9H-carbazole}, HL((t)Bu/(t)Bu) {3,6-di(tert-butyl)-1,8-bis[5-(3-(4-tert-butyl)benzyl-1,2,3-triazole)]-9H-carbazole}, HL(H/H) {1,8-bis[5-(3-benzyl-1,2,3-triazole)]-9H-carbazole} and HL(H/(t)Bu) {1,8-bis[5-(3-(4-tert-butyl)benzyl-1,2,3-triazole)]-9H-carbazole}, were prepared and complexed with cobalt(ii) tetrafluoroborate. In situ air oxidation resulted in cobalt(iii) complexes 1-4 with the general formula [Co(III)(L)2]BF4·xH2O (1: L = L((t)Bu/H), x = 2; 2: L = L((t)Bu/(t)Bu), x = 1; 3: L = L(H/H), x = 0...
March 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28332067/preoperative-chronic-sinusitis-as-significant-cause-of-postoperative-infection-and-implant-loss-after-sinus-augmentation-from-a-lateral-approach
#7
Ayako Kozuma, Masanori Sasaki, Katsuhiro Seki, Takeshi Toyoshima, Hiroyuki Nakano, Yoshihide Mori
OBJECTIVES: Among intra/postoperative complications of sinus augmentation from a lateral approach, postoperative infection and implant loss are particularly important because they have irreversible consequences. The purpose of this study was to determine the causes of postoperative infection and implant loss after a lateral approach and to determine the appropriate prophylaxis and therapy. MATERIALS AND METHODS: In total, 109 patients (121 sinuses, 252 implants) were included in this study...
March 22, 2017: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28331845/irreversible-electroporation-of-hepatocellular-carcinoma-patient-selection-and-perspectives
#8
REVIEW
Asha Zimmerman, David Grand, Kevin P Charpentier
Irreversible electroporation (IRE) is a novel form of tissue ablation that uses high-current electrical pulses to induce pore formation of the cell lipid bilayer, leading to cell death. The safety of IRE for ablation of hepatocellular carcinoma (HCC) has been established. Outcome data for ablation of HCC by IRE are limited, but early results are encouraging and suggest equivalency to the outcomes obtained for thermal ablation for appropriately selected, small (<3 cm) tumors. Long-term oncologic efficacy and histopathologic response data have not been published, and therefore, application of IRE for the treatment of HCC should still be viewed with caution...
2017: Journal of Hepatocellular Carcinoma
https://www.readbyqxmd.com/read/28331576/bumblebees-require-visual-pollen-stimuli-to-initiate-and-multimodal-stimuli-to-complete-a-full-behavioral-sequence-in-close-range-flower-orientation
#9
Saskia Wilmsen, Robin Gottlieb, Robert R Junker, Klaus Lunau
Flower visits are complex encounters, in which animals are attracted by floral signals, guided toward the site of the first physical contact with a flower, land, and finally take up floral rewards. At close range, signals of stamens and pollen play an important role to facilitate flower handling in bees, yet the pollen stimuli eliciting behavioral responses are poorly known. In this study, we test the response of flower-naive bumblebees (Bombus terrestris) toward single and multimodal pollen stimuli as compared to natural dandelion pollen...
March 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28331457/visual-loss-retinal-hemorrhages-and-optic-disc-edema-resulting-from-thiamine-deficiency-following-bariatric-surgery-complicated-by-prolonged-vomiting
#10
Andrew W Lawton, Nicholas E Frisard
BACKGROUND: Vision loss resulting from thiamine deficiency is a recognized complication of bariatric surgery. Most patients with such vision loss have Wernicke encephalopathy with characteristic changes seen on neuroimaging. Other patients may have retinal hemorrhages, optic disc edema, and peripheral neuropathy without Wernicke encephalopathy. The risk for thiamine deficiency is potentiated by the presence of prolonged vomiting. CASE REPORT: A 37-year-old female presented with abrupt onset of vision loss and peripheral neuropathy following bariatric surgery...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/28331001/quantitative-tyrosine-phosphoproteomics-of-egfr-tyrosine-kinase-inhibitor-treated-lung-adenocarcinoma-cells-reveals-potential-novel-biomarkers-of-therapeutic-response
#11
Xu Zhang, Tapan Maity, Manoj K Kashyap, Mukesh Bansal, Abhilash Venugopalan, Sahib Singh, Shivangi Awasthi, Arivusudar Marimuthu, Harrys Kishore Charles Jacob, Natalya Belkina, Stephanie Pitts, Constance M Cultraro, Shaojian Gao, Fatos Kirkali, Romi Biswas, Raghothama Chaerkady, Andrea Califano, Akhilesh Pandey, Udayan Guha
Mutations in the Epidermal growth factor receptor (EGFR) kinase domain, such as the L858R missense mutation and deletions spanning the conserved sequence 747LREA750, are sensitive to tyrosine kinase inhibitors (TKIs). The gatekeeper site residue mutation, T790M accounts for around 60% of acquired resistance to EGFR TKIs. The first generation EGFR TKIs, erlotinib and gefitinib, and the second generation inhibitor, afatinib are FDA approved for initial treatment of EGFR mutated lung adenocarcinoma. The predominant biomarker of EGFR TKI responsiveness is the presence of EGFR TKI-sensitizing mutations...
March 22, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28330646/is-it-time-for-a-change-in-the-approach-to-chemical-burns-the-role-of-diphoterine-%C3%A2-in-the-management-of-cutaneous-and-ocular-chemical-injuries
#12
REVIEW
C J Lewis, A Al-Mousawi, A Jha, K P Allison
A multitude of household and occupational compounds have the potential to induce chemical burns to the eye and skin. Without prompt intervention, irreversible visual loss and disfigurement may prevail. Diphoterine(®) and Hexafluorine(®) are amphoteric and hypertonic chelating solutions used in the management of general chemical and hydrofluoric acid burns, respectively. They rapidly neutralise both acid and alkali agents without heat release and limit diffusion, making them superior to water irrigation alone...
February 27, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28330153/an-evaluation-of-the-major-factors-influencing-the-removal-of-copper-ions-using-the-egg-shell-dromaius-novaehollandiae-chitosan-agaricus-bisporus-composite
#13
R K Anantha, S Kota
Rapid industrialisation, technological development, urbanization and increase in population in the recent past coupled with unplanned and unscientific disposal methods led to increased heavy metal levels in water. Realizing the need for development of eco-friendly and cost effective methods, the present investigation was done for the adsorptive removal of copper from aqueous solutions with Dromaius novaehollandiae eggshell and chitosan composite. By one variable at a time method, the optimum contact time was found to be 60 min with an adsorbent dosage of 8 g/L at pH 6, initial adsorbate concentration of 20 mg/L and temperature 30 °C...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28329845/spatiotemporal-progression-and-remission-of-lesions-in-the-rat-brain-following-acute-intoxication-with-diisopropylfluorophosphate
#14
Sílvia Sisó, Brad A Hobson, Danielle J Harvey, Donald A Bruun, Douglas J Rowland, Joel R Garbow, Pamela J Lein
Similar to organophosphate (OP) nerve agents, diisopropylfluorophosphate (DFP) rapidly and irreversibly inhibits acetylcholinesterase, leading to convulsions that can progress to status epilepticus (SE). However, in contrast to the OP nerve agents, the long-term consequences of DFP-induced SE are not well known. Thus, we characterized the spatiotemporal profile of neuropathology during the first two months following acute DFP intoxication. Adult, male Sprague Dawley rats administered pyridostigmine bromide (0...
March 7, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28328500/the-role-of-haptic-feedback-in-robotic-assisted-retinal-microsurgery-systems-a-systematic-review
#15
Julia A Griffin, Weihang Zhu, Chang S Nam
Retinal microsurgery is one of the most technically difficult surgeries since it is performed at the threshold of human capability. If certain retinal conditions are left untreated, they can lead to severe damage, including irreversible blindness. Thus, techniques for reliable retinal microsurgery operations are critical. Recent research shows promise for improving surgical safety by implementing various types of sensory input and output. Sensory information is used to inform the surgeon about the environment inside the eye in real time...
January 2017: IEEE Transactions on Haptics
https://www.readbyqxmd.com/read/28328228/reversible-morphological-control-of-cholecystokinin-tetrapeptide-amyloid-assemblies-as-a-function-of-ph
#16
Frédéric Gobeaux, Florence Porcher, Rajeev Dattani
Most amyloid assemblies are seen as irreversible and exhibit polymorphism because their assembly is kinetically controlled and different structures are trapped during the aggregation process. However, in the specific case of peptide hormones, formation of amyloid assemblies for storage purposes has been reported. This suggests a strict control of assembly and the ability to disassemble upon hormone secretion. In the present work, we have sought to test these assertions with a short peptide, the cholecystokinin (or gastrin) tetrapeptide (CCK-4), that has been found in both gastrointestinal tract and central nervous system, and whose sequence is shared by a large number of hormones...
March 22, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28327777/predicting-and-assessing-rupture-in-protein-gels-under-oscillatory-shear
#17
Brice Saint-Michel, Thomas Gibaud, Sébastien Manneville
Soft materials may break irreversibly upon applying sufficiently large shear oscillations, a process whose physical mechanism remains largely elusive. In this work, the rupture of protein gels made of sodium caseinate under an oscillatory stress is shown to occur in an abrupt, brittle-like manner. Upon increasing the stress amplitude, the build-up of harmonic modes in the strain response can be rescaled for all gel concentrations. This rescaling yields an empirical criterion to predict the rupture point way before the samples are significantly damaged...
March 22, 2017: Soft Matter
https://www.readbyqxmd.com/read/28327623/long-term-effectiveness-of-irreversible-electroporation-in-a-murine-model-of-colorectal-liver-metastasis
#18
P Sánchez-Velázquez, Q Castellví, A Villanueva, M Iglesias, R Quesada, C Pañella, M Cáceres, D Dorcaratto, A Andaluz, X Moll, J M Burdío, L Grande, A Ivorra, F Burdío
Irreversible electroporation (IRE) has recently gained in popularity as an ablative technique, however little is known about its oncological long-term outcomes. To determine the long-time survival of animals treated with a high dose of IRE and which histological changes it induces in tumoral tissue, IRE ablation was performed in forty-six athymic-nude mice with KM12C tumors implanted in the liver by applying electric current with different voltages (2000 V/cm, 1000 V/cm). The tumors were allowed to continue to grow until the animals reached the end-point criteria...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28327606/magnetic-frustration-of-graphite-oxide
#19
Dongwook Lee, Jiwon Seo
Delocalized π electrons in aromatic ring structures generally induce diamagnetism. In graphite oxide, however, π electrons develop ferromagnetism due to the unique structure of the material. The π electrons are only mobile in the graphitic regions of graphite oxide, which are dispersed and surrounded by sp(3)-hybridized carbon atoms. The spin-glass behavior of graphite oxide is corroborated by the frequency dependence of its AC susceptibility. The magnetic susceptibility data exhibit a negative Curie temperature, field irreversibility, and slow relaxation...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28326084/hiv-infection-and-compromised-mucosal-immunity-oral-manifestations-and-systemic-inflammation
#20
REVIEW
Samantha E Heron, Shokrollah Elahi
Mucosal surfaces account for the vast majority of HIV transmission. In adults, HIV transmission occurs mainly by vaginal and rectal routes but rarely via oral route. By contrast, pediatric HIV infections could be as the result of oral route by breastfeeding. As such mucosal surfaces play a crucial role in HIV acquisition, and spread of the virus depends on its ability to cross a mucosal barrier. HIV selectively infects, depletes, and/or dysregulates multiple arms of the human immune system particularly at the mucosal sites and causes substantial irreversible damage to the mucosal barriers...
2017: Frontiers in Immunology
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