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https://www.readbyqxmd.com/read/28650621/novel-cdta-based-bifunctional-chelators-for-stable-and-inert-mn-ii-complexation-synthesis-and-physicochemical-characterization
#1
Christian Vanasschen, Enikő Molnár, Gyula Tircsó, Ferenc K Kálmán, Éva Tóth, Marie Brandt, Heinz H Coenen, Bernd Neumaier
In the search for Mn(II) MR and PET/MR imaging agents with optimal balance between thermodynamic stability, kinetic inertness, and relaxivity, two novel bifunctional Mn(II) chelators (BFMnCs) based on CDTA (trans-1,2-diaminocyclohexane-N,N,N',N'-tetraacetic acid) were synthesized. A six-step synthesis, involving the buildup of a functionalized trans-1,2-diaminocyclohexane core, provided CuAAC-reactive 6a and 6b bearing an alkyne or azide substituent on the cyclohexane ring, respectively (CuAAC = Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition)...
June 26, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28649637/the-adaptation-of-escherichia-coli-cells-grown-in-simulated-microgravity-for-an-extended-period-is-both-phenotypic-and-genomic
#2
Madhan R Tirumalai, Fathi Karouia, Quyen Tran, Victor G Stepanov, Rebekah J Bruce, C Mark Ott, Duane L Pierson, George E Fox
Microorganisms impact spaceflight in a variety of ways. They play a positive role in biological systems, such as waste water treatment but can be problematic through buildups of biofilms that can affect advanced life support. Of special concern is the possibility that during extended missions, the microgravity environment will provide positive selection for undesirable genomic changes. Such changes could affect microbial antibiotic sensitivity and possibly pathogenicity. To evaluate this possibility, Escherichia coli (lac plus) cells were grown for over 1000 generations on Luria Broth medium under low-shear modeled microgravity conditions in a high aspect rotating vessel...
2017: NPJ Microgravity
https://www.readbyqxmd.com/read/28649470/determinants-of-seasonal-changes-in-availability-of-food-patches-for-elephants-loxodonta-africana-in-a-semi-arid-african-savanna
#3
Bruce W Clegg, Timothy G O'Connor
Loss of biodiversity caused by impact of elephants (Loxodonta africana) on African woodlands may require a management response, but any action should be based on an understanding of why elephants choose to utilise trees destructively. Comprehension of elephant feeding behaviour requires consideration of the relative value of the plant groups they may potentially consume. Profitability of available food is partly determined by the time to locate a food patch and, therefore, as a foundation for understanding the influence of food availability on diet selection, key controls on the density of grass, forb, and browse patches were investigated across space and time in a semi-arid African savanna...
2017: PeerJ
https://www.readbyqxmd.com/read/28649321/little-association-of-biological-trait-values-with-environmental-variables-in-invasive-alien-round-goby-neogobius-melanostomus
#4
Alexander F Cerwenka, Alfredo Pagnotta, Carolin Böker, Joerg Brandner, Juergen Geist, Ulrich K Schliewen
The relative importance of species-specific biological trait characteristics and environmental factors in invasions of nonindigenous species remains controversial because both have mostly been studied independently. Thus, the main objective of this study was to examine the correlation of biological traits with environmental variation in the globally invasive round goby Neogobius melanostomus from the upper Danube River. Based on a sample of 653 specimens along a continuous 200 km river pathway, links between nine environmental factors (substrate-type, six water measurements, and the communities of fishes and macroinvertebrates) and seven biological traits (nutritional and energetic status, trade-offs of parasite resistance and resource allocation, and three growth proxies) were analyzed...
June 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28649074/neurochemical-and-behavioral-effects-of-green-tea-camellia-sinensis-as-observed-in-animals-exposed-to-restraint-stress
#5
Huma Ikram, Beenish Mirza, Darakhshan Jabeen Haleem
Clinical studies on psychiatric patients suggest that life events stress precipitates depression. The possible involvement of 5-Hydroxy tryptamine (5-HT; Serotonin) in depression and other behavioral deficits is also suggested by clinical studies. As a natural stimulant, green tea (Camellia Sinensis) diminishes stress, worry and anxiety, allowing the brain to focus and concentrate better. Previously we have reported that beneficial effects of green tea might be associated with altered levels of 5-HT, which in turn may help in coping with stress...
March 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28648862/octacosanol-educes-physico-chemical-attributes-release-and-bioavailability-as-modified-nanocrystals
#6
Surashree Sen Gupta, Mahua Ghosh
Octacosanol is a lesser known nutraceutical with the potential for treatment of several inflammatory diseases, high cholesterol, Parkinson's symptoms and tumour growth along with the capacity to improve athletic performance. But its lipophilicity and large structure inhibits extended solubility in water resulting in poor absorption and a low bioavailability. In the present work, sodium salt of octacosyl sulfate was synthesized. It displayed improved water solubility. Its nanocrystals, synthesized by means of nanoprecipitation technique, enhanced diffusion velocity, antioxidant capacity, shelf-life, penetrability and bioavailability...
June 22, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28648819/%C3%AE-9-tetrahydrocannabinol-%C3%AE-9-thc-administration-after-neonatal-exposure-to-phencyclidine-potentiates-schizophrenia-related-behavioral-phenotypes-in-mice
#7
Guadalupe Rodríguez, Nichole M Neugebauer, Katherine Lan Yao, Herbert Y Meltzer, John G Csernansky, Hongxin Dong
The clinical onset of schizophrenia often coincides with cannabis use in adolescents and young adults. However, the neurobiological consequences of this co-morbidity are not well understood. In this study, we examined the effects of Δ9-THC exposure during early adulthood on schizophrenia-related behaviors using a developmental mouse model of schizophrenia. Phencyclidine (PCP) or saline was administered once in neonatal mice (at P7; 10mg/kg). In turn, Δ9-THC or saline was administered sub-acutely later in life to cohorts of animals who had received either PCP or saline (P55-80, 5mg/kg)...
June 22, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28647879/disposal-of-household-pharmaceuticals-in-insular-communities-social-attitude-behaviour-evaluation-and-prevention-activities
#8
Antonis A Zorpas, Maria Dimitriou, Irene Voukkali
The increase in medicine and drug consumption have resulted in identifying these emerging pollutants in all aquatic compartments, ranging from surface water and groundwater resources to the marine environment. Pharmaceuticals are an indispensable part of life today. A large number of pharmaceuticals are used in a daily basis in the treatment, prevention, cure or diagnosis of diseases or to otherwise enhance people's physical or mental well-being. This paper focuses on the evaluation of the attitude of citizens in Cyprus regarding the disposal of pharmaceuticals as well as to identify the main reasons why pharmaceutical wastes are produced...
June 25, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28647874/alleviative-effect-of-licorice-on-copper-chloride-induced-oxidative-stress-in-the-brain-biochemical-histopathological-immunohistochemical-and-genotoxic-study
#9
Heba El-Sayed Mostafa, Eman Ahmad Alaa-Eldin, Dalia Abdallah El-Shafei, Nehal S Abouhashem
Although copper is an essential micronutrient involved in a variety of biological processes indispensable for sustaining life, it can be toxic when administered in excess. Licorice (Glycyrrhizaglabra) has been used in Chinese folk medicine for the treatment of various disorders. Licorice has the biological capabilities of detoxication, antioxidation, and antiinfection. Here, we test the hypothesis that licorice could ameliorate copper-induced neurotoxic and genotoxic effects in adult male albino rats. For this purpose, 48 adult male albino rats were randomized into five groups: group I (8 rats), untreated control; group II (16 rats), subdivided into; vehicle control IIa (8 rats) which received 1 mL saline twice weekly intraperitoneally for 8 weeks and vehicle control IIb (8 rats) received 0...
June 24, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28647498/the-role-of-the-peptides-at-the-origin-of-life
#10
Søren Toxvaerd
The peptides in biosystems are polymers of L-amino acids, but they racemize slowly by an active isomerization kinetics. The chemical reactions in biosystems are, however, reversible and here we show by a thermodynamics analysis and by comprehensive Molecular Dynamics simulations of models of peptides, that the isomerization kinetics racemizes the peptides at high water activity, in agreement with experimental observations of aging of peptides, but enhances homochirality at a smaller water activity. The main conclusion of the simulations is that it is only possible to obtain and maintain homochirality in the presence of a hydrophobic compact core in a peptide of hundreds of chiral units and at a low water activity, and thus the establishment of homochirality at the origin of life and aging of proteins in biosystems might be strongly connected...
June 21, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28646832/diet-for-women-with-irritable-bowel-syndrome-a-preliminary-study
#11
Diana Wasiluk, Lucyna Ostrowska, Ewa Stefańska, Agnieszka Janke, Grażyna Jurkowska
Background: Irritable Bowel Syndrome (IBS) is one of the most frequent digestive system diseases, of various medical signs. It is assumed that proper life style, including appropriate, rational diet is a factor helpful for treating such a disorder. Objective: The purpose of this paper was to assess the selected dietary habits, and to evaluate the nutritional value of daily food rations for patients with a mixed type of Irritable Bowel Syndrome. Material and Methods: The questionnaire survey involved a group of 32 women suffering from a mixed type of Irritable Bowel Syndrome (The Rome III Diagnostic Criteria were used to diagnose the disease)...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28646316/identifying-major-events-in-two-sturgeons-life-using-pectoral-fin-spine-ring-structure-exploring-the-use-of-a-non-destructive-method
#12
Shima Bakhshalizadeh, Ali Bani, Shahram Abdolmalaki, Natalie Moltschaniwskyj
Maturation is one of the most important life history traits that influences on many ecological characteristics of animals. This study aimed to describe the indirect distinguish of first reproduction and habitat shift (transition from the pelagic to benthic environment), using the width of translucent and annuluses of the pectoral fin spine of two sturgeon species, Persian sturgeon, Acipenser persicus, and starry sturgeon, Acipenser stellatus. Interpretation of growth bands in pectoral fin sections was done objectively using direct reading of thin sections and image analysis...
June 23, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28646314/ozone-and-desiccation-tolerance-in-chlorolichens-are-intimately-connected-a-case-study-based-on-two-species-with-different-ecology
#13
Stefano Bertuzzi, Elisa Pellegrini, Fabio Candotto Carniel, Guido Incerti, Giacomo Lorenzini, Cristina Nali, Mauro Tretiach
Tropospheric ozone (O3) causes severe damage to many vascular plants but not to lichens. It was recently suggested that this may be due to their high levels of natural defences against the oxidative bursts associated to their fluctuating water content. In this study, the combined effects of watering regime (with or without a daily spray of distilled water), air relative humidity (20 ± 5 vs. 80 ± 5% RH) and O3 (250 vs. 0 ppb, 5 h day(-1) for 2 weeks) were monitored in two chlorolichens with different ecology, Parmotrema perlatum and Xanthoria parietina...
June 23, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28646114/staphylococcus-aureus-strain-newman-photoinactivation-and-cellular-response-to-sunlight-exposure
#14
Jill S McClary, Lauren M Sassoubre, Alexandria B Boehm
Sunlight influences microbial water quality of surface waters. Previous studies have investigated photoinactivation mechanisms and cellular photostress responses of fecal indicator bacteria (FIB), including Escherichia coli and enterococci, but further work is needed to characterize photostress responses of bacterial pathogens. Here we investigate the photoinactivation of Staphylococcus aureus (strain Newman), a pigmented, waterborne pathogen of emerging concern. We measured photodecay using standard culture-based assays and cellular membrane integrity; and investigated photostress response by measuring the relative number of mRNA transcripts of select oxidative stress, DNA repair, and metabolism genes...
June 23, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28646037/early-exposure-to-chronic-hypoxia-induces-short-and-long-term-regulation-of-hemoglobin-gene-expression-in-european-sea-bass-dicentrarchus-labrax
#15
Laura Cadiz, Arianna Servili, Patrick Quazuguel, Lauriane Madec, José-Luis Zambonino-Infante, David Mazurais
European sea bass (Dicentrarchus labrax) inhabits coastal waters and may be exposed to hypoxia at different life stages, requiring physiological and behavioral adaptation. In the present study, we attempted to determine whether regulation of hemoglobin (Hb) gene expression plays a role in the physiological response to chronic moderate hypoxia in whole larvae and hematopoietic tissues (head kidney and spleen) of juveniles. We also tested the hypothesis that hypoxia exposure at the larval stage could induce a long-term effect on the regulation of Hb gene expression...
June 23, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28645159/genomic-characterization-of-two-novel-sar11-isolates-from-the-red-sea-including-the-first-strain-of-the-sar11-ib-clade
#16
Francy Jimenez-Infante, David Kamanda Ngugi, Manikandan Vinu, Jochen Blom, Intikhab Alam, Vladimir B Bajic, Ulrich Stingl
The SAR11 clade (Pelagibacterales) is a diverse group that forms a monophyletic clade within the Alphaproteobacteria, and constitutes up to one third of all prokaryotic cells in the photic zone of most oceans. Pelagibacterales are very abundant in the warm and highly saline surface waters of the Red Sea, raising the question of adaptive traits of SAR11 populations in this water body and warmer oceans through the world. In this study, two pure cultures were successfully obtained from surface waters on the Red Sea, one isolate of subgroup Ia and one of the previously uncultured SAR11 Ib lineage...
June 22, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/28645067/using-a-detailed-inventory-of-a-large-wastewater-treatment-plant-to-estimate-the-relative-importance-of-construction-to-the-overall-environmental-impacts
#17
Serni Morera, Lluís Corominas, Miquel Rigola, Manel Poch, Joaquim Comas
The aim of this work is to quantify the relative contribution to the overall environmental impact of the construction phase compared to the operational phase for a large conventional activated sludge wastewater treatment plant (WWTP). To estimate these environmental impacts, a systematic procedure was designed to obtain the detailed Life Cycle Inventories (LCI) for civil works and equipment, taking as starting point the construction project budget and the list of equipment installed at the Girona WWTP, which are the most reliable information sources of materials and resources used during the construction phase...
June 2, 2017: Water Research
https://www.readbyqxmd.com/read/28644860/time-dependent-genetic-analysis-links-field-and-controlled-environment-phenotypes-in-the-model-c4-grass-setaria
#18
Max J Feldman, Rachel E Paul, Darshi Banan, Jennifer F Barrett, Jose Sebastian, Muh-Ching Yee, Hui Jiang, Alexander E Lipka, Thomas P Brutnell, José R Dinneny, Andrew D B Leakey, Ivan Baxter
Vertical growth of plants is a dynamic process that is influenced by genetic and environmental factors and has a pronounced effect on overall plant architecture and biomass composition. We have performed six controlled growth trials of an interspecific Setaria italica x Setaria viridis recombinant inbred line population to assess how the genetic architecture of plant height is influenced by developmental queues, water availability and planting density. The non-destructive nature of plant height measurements has enabled us to monitor height throughout the plant life cycle in both field and controlled environments...
June 23, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28643674/microbiological-and-serological-control-of-escherichia-coli-o157-h7-in-kindergarten-staff-in-buenos-aires-city-and-suburban-areas
#19
Romina J Fernández-Brando, María Marta Amaral, Andrés E Ciocchini, Leticia V Bentancor, Jorge A Trelles, Marcelo Da Rocha, Martín Landriel, Mariana Ugarte, Gabriel Briones, Cristina Ibarra, Marina S Palermo
Shiga toxin (Stx)-producing Escherichia coli (STEC) infections are implicated in the development of the life-threatening hemolytic-uremic syndrome (HUS). Despite the magnitude of the social and economic problems caused by HUS, no licensed vaccine or effective therapy is currently available for human use. Prevention of STEC infections continues being the most important measure to reduce HUS incidence. This is especially true for Argentina where HUS incidence among children is extremely high and shows an endemic pattern...
2017: Medicina
https://www.readbyqxmd.com/read/28642069/chronic-choline-supplementation-improves-cognitive-and-motor-performance-via-modulating-oxidative-and-neurochemical-status-in-rats
#20
Saiqa Tabassum, Saida Haider, Saara Ahmad, Syeda Madiha, Tahira Parveen
Choline, an essential nutrient, accounts for multiple functions in the body and brain. While its beneficial effects on healthy adults are not clear, choline supplementation is important during pregnancy for brain development, in elderly patients for support of cognitive performance and in patients with neurological disorders to reduce memory deficits. Thus, the aim of this study is to investigate whether choline administration in healthy adult rats beneficially impacts cognitive and locomotor performance, and associated oxidative and neurochemical outcomes...
June 19, 2017: Pharmacology, Biochemistry, and Behavior
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