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https://www.readbyqxmd.com/read/29452568/primary-cilia-regulated-transcriptome-in-the-renal-collecting-duct
#1
Sami G Mohammed, Francisco J Arjona, Eric H J Verschuren, Zeineb Bakey, Wynand Alkema, Sacha van Hijum, Miriam Schmidts, René J M Bindels, Joost G J Hoenderop
Renal tubular cells respond to mechanical stimuli generated by urinary flow to regulate the activity and transcript abundance of important genes for ion handling, cellular homeostasis, and proper renal development. The primary cilium, a mechanosensory organelle, is postulated to regulate this mRNA response. The aim of this study is to reveal the transcriptome changes of tubular epithelia in response to fluid flow and determine the role of primary cilia in this process. Inner-medullary collecting duct (CD) cells were subjected to either static or physiologically relevant fluid flow (∼0...
February 8, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29414505/inter-operator-variability-in-compartmental-kinetic-analysis-of-18f-fluoromisonidazole-dynamic-pet
#2
Sadek A Nehmeh, Jazmin Schwartz, Milan Grkovski, Ivan Yeung, Charles M Laymon, Mark Muzi, John L Humm
PURPOSE: To assess the inter-operator variability in compartment analysis (CA) of dynamic-FMISO (dyn-FMISO) PET. METHODS: Study-I: Five investigators conducted CA for 23 NSCLC dyn-FMISO tumor time-activity-curves. Study-II: Four operators performed CA for four NSCLC dyn-FMISO datasets. Repeatability of Kinetic-Rate-Constants (KRCs) was assessed. RESULTS: Study-I: Strong correlation (ICC > 0.9) and interchangeable results among operators existed for all KRCs...
January 12, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29405326/hemodynamic-effects-of-connection-to-continuous-renal-replacement-therapy-in-a-pediatric-animal-model
#3
Sarah Nicole Fernández Lafever, Maria Jose Santiago, Jorge López, Rafael González, María José Solana, Javier Urbano, Jesus Lopez-Herce
To assess the hemodynamic effects of connection to continuous renal replacement therapy (CRRT) in a pediatric experimental animal model. Prospective experimental study was performed using piglets between 2 and 3 months of age and 9-11 kg. CRRT with a PrismaflexR monitor and HF20 filter (surface of 0.2 m2 ) was started after monitoring and anesthetic induction with an initial blood flow at 20 mL/min with 10 mL/min increases every minute until the goal flow of 5 mL/kg/min was achieved. Heart rate, blood pressure, central venous pressure, cardiac index, and renal blood flow were registered at baseline, 5, 15, 30, 60, 120, 180, 240, and 360 min...
February 6, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29393580/bosentan-therapy-for-pulmonary-arterial-hypertension-and-chronic-thromboembolic-pulmonary-hypertension-a-systemic-review-and-meta-analysis
#4
Xinwang Chen, Zhenguo Zhai, Ke Huang, Wanmu Xie, Jun Wan, Chen Wang
BACKGROUND: Bosentan therapy has been recommended for pulmonary arterial hypertension (PAH) and might be beneficial for chronic thromboembolic pulmonary hypertension (CTEPH). We aimed to evaluate the specific effects of bosentan for PAH and CTEPH. METHODS: We performed a systemic review and meta-analysis of randomized controlled trials (RCTs) comparing efficacy and safety of bosentan treatment for PAH and CTEPH through major biomedical database. RESULTS: A total of 10 RCTs including 1185 patients were enrolled...
February 2, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29383684/dynorphin-and-%C3%AE%C2%BA-opioid-receptor-dysregulation-in-the-dopaminergic-reward-system-of-human-alcoholics
#5
Igor Bazov, Daniil Sarkisyan, Olga Kononenko, Hiroyuki Watanabe, Tatiana Yakovleva, Anita C Hansson, Wolfgang H Sommer, Rainer Spanagel, Georgy Bakalkin
Molecular changes induced by excessive alcohol consumption may underlie formation of dysphoric state during acute and protracted alcohol withdrawal which leads to craving and relapse. A main molecular addiction hypothesis is that the upregulation of the dynorphin (DYN)/κ-opioid receptor (KOR) system in the nucleus accumbens (NAc) of alcohol-dependent individuals causes the imbalance in activity of D1- and D2 dopamine receptor (DR) expressing neural circuits that results in dysphoria. We here analyzed post-mortem NAc samples of human alcoholics to assess changes in prodynorphin (PDYN) and KOR (OPRK1) gene expression and co-expression (transcriptionally coordinated) patterns...
January 30, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29374922/-effects-of-application-of-pulse-contour-cardiac-output-monitoring-technology-in-early-treatment-of-patients-with-large-area-burns
#6
D Y Wang, W G Xie, M M Xi, Z Li, B Wang
Objective: To analyze the changes and relationship of early hemodynamic indexes of patients with large area burns monitored by pulse contour cardiac output (PiCCO) monitoring technology, so as to assess the guiding value of this technology in the treatment of patients with large area burns during shock period. Methods: Eighteen patients with large area burns, confirming to the study criteria, were admitted to our unit from May 2016 to May 2017. Pulse contour cardiac output index (PCCI), systemic vascular resistance index (SVRI), global end-diastolic volume index (GEDVI), and extravascular lung water index (EVLWI) of patients were monitored by PiCCO instrument from admission to post injury day (PID) 7, and they were calibrated and recorded once every four hours...
January 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29352448/mesenchymal-stem-cell-deformability-and-implications-for-microvascular-sequestration
#7
Herbert H Lipowsky, Daniel T Bowers, Brittany L Banik, Justin L Brown
Mesenchymal stem cells (MSCs) have received considerable attention in regenerative medicine, particularly in light of prospects for targeted delivery by intra-arterial injection. However, little is known about the mechanics of MSC sequestration in the microvasculature and the yield pressure (P Y ), above which MSCs will pass through microvessels of a given diameter. The objectives of the current study were to delineate the dependency of P Y on cell size and the heterogeneity of cell mechanical properties and diameters (D CELL ) of cultured MSCs...
January 19, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29306249/biomarker-and-shear-stress-in-secondary-pediatric-pulmonary-hypertension
#8
Ayhan Pektaş, Rana Olguntürk, Serdar Kula, Erman Çilsal, Ayşe Deniz Oğuz, Fatma Sedef Tunaoğlu
Background/aim: Endothelial dysfunction, tissue damage, inflammation, and microthrombosis are involved in the pathogenesis of pulmonary hypertension (PH), which may be present as a complication of congenital heart diseases. This study aims to identify how indicators of endothelial dysfunction (shear stress), tissue damage (brain natriuretic peptide and troponin T), inflammation (C-reactive protein (CRP)), and microthrombosis (D-dimer and von Willebrand factor) are altered in children with congenital left-to-right shunting...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29306163/influence-of-stormwater-runoff-on-macroinvertebrates-in-a-small-urban-river-and-a-reservoir
#9
Ryszard Gołdyn, Barbara Szpakowska, Dariusz Świerk, Piotr Domek, Jan Buxakowski, Renata Dondajewska, Danuta Barałkiewicz, Adam Sajnóg
The impact of stormwater on benthic macroinvertebrates was studied in two annual cycles. Five small catchments drained by stormwater sewers to a small urban river and a small and shallow reservoir situated in its course were selected. These catchments were located in residential areas with single-family houses or blocks of flats as well as industrial areas, i.e., a car factory, a glassworks and showroom as well as the parking lots of a car dealer and servicing company. In addition to the five stations situated in the vicinity of the stormwater outlets, three stations not directly influenced by stormwater were also established...
January 3, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29300906/postoperative-left-ventricular-function-in-different-types-of-pulmonary-hypertension-a-comparative-study
#10
Tom Verbelen, Alexander Van De Bruaene, Bjorn Cools, Dirk Van Raemdonck, Marion Delcroix, Filip Rega, Bart Meyns
OBJECTIVES: Left ventricular dysfunction after pulmonary endarterectomy is well described. Left ventricular failure has only been described after lung transplantation for pulmonary arterial hypertension (PAH). We sought to identify factors that contribute to this failure and hypothesized that atrial septostomy before transplantation could prevent this complication. METHODS: From our database, all bilateral lung transplants for PAH (n = 24) and all pulmonary endarterectomies, with a minimal reduction of 800 dyn⋅s⋅cm-5 (n = 27), were selected...
January 2, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29300214/no-effect-of-muscle-stretching-within-a-full-dynamic-warm-up-on-athletic-performance
#11
Anthony J Blazevich, Nicholas D Gill, Thue Kvorning, Anthony D Kay, Alvin Goh, Bradley Hilton, Eric J Drinkwater, David G Behm
PURPOSE: To examine the effects of static and dynamic stretching routines performed as part of a comprehensive warm-up on flexibility and sprint running, jumping and change of direction tests in team sport athletes. METHODS: A randomized, controlled, cross-over study design with experimenter blinding was conducted. On separate days, 20 male team sport athletes completed a comprehensive warm-up routine. After a low-intensity warm-up a 5-s static stretch (5S), 30-s static stretch (30S; 3×10-s stretches), 5-repetition (per muscle group) dynamic stretch (DYN) or no stretch (NS) protocol was completed; stretches were done on 7 lower body and 2 upper body regions...
January 4, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29296853/role-of-calcium-in-regulating-the-intra-and-extracellular-cleavage-of-von-willebrand-factor-by-the-protease-adamts13
#12
Shobhit Gogia, Anju Kelkar, Changjie Zhang, Kannayakanahalli M Dayananda, Sriram Neelamegham
von Willebrand factor (VWF) and the metalloprotease a disintegrin and metalloprotease with thrombospondin type 1 motif 13 (ADAMTS13) are present both within endothelial cells (ECs) and in peripheral blood. Calcium concentrations are lower in intracellular compartments (80-400 μM) compared with the extracellular milieu (∼1.25 mM). Because low calcium favors VWF A2-domain proteolysis by ADAMTS13, the dependence of proteolysis rates on calcium was assayed both within ECs and in blood. Confocal microscopy studies demonstrate partial perinuclear colocalization of VWF with ADAMTS13 in human umbilical vein ECs (HUVECs)...
October 24, 2017: Blood Advances
https://www.readbyqxmd.com/read/29273415/design-synthesis-and-opioid-activity-of-arodyn-analogs-cyclized-by-ring-closing-metathesis-involving-tyr-allyl
#13
Wei-Jie Fang, Thomas F Murray, Jane V Aldrich
Kappa (κ) opioid receptor selective antagonists are useful pharmacological tools in studying κ opioid receptors and have potential to be used as therapeutic agents for the treatment of a variety of diseases including mood disorders and drug addiction. Arodyn (Ac[Phe1-3,Arg4,d-Ala8]Dyn A-(1-11)NH2) is a linear acetylated dynorphin A (Dyn A) analog that is a potent and selective κ opioid receptor antagonist (Bennett et al. J Med Chem 2002;45:5617-5619) and prevents stress-induced reinstatement of cocaine-seeking behavior following central administration (Carey et al...
November 21, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29240797/a-mucoadhesive-thermoreversible-in-situ-nasal-gel-of-geniposide-for-neurodegenerative-diseases
#14
Yingting Wang, Shulong Jiang, Hongli Wang, Haiyan Bie
Neurodegenerative diseases are becoming prevalent as the population ages. Geniposide could inhibit oxidative stress, reduce apoptosis, protect neuron, and has been used for therapy of the neurodegenerative diseases. The bioavailability of geniposide by nasal route is greater than that by oral administration. However, mucociliary clearance is a rate-limiting factor for nasal route administration. The objective of this study was to develop and evaluate a mucoadhesive, thermoreversible in situ nasal gel of geniposide...
2017: PloS One
https://www.readbyqxmd.com/read/29229797/capturing-the-flow-beneath-water-waves
#15
REVIEW
A Nachbin, R Ribeiro-Junior
Recently, the authors presented two numerical studies for capturing the flow structure beneath water waves (Nachbin and Ribeiro-Junior 2014 Disc. Cont. Dyn. Syst. A34, 3135-3153 (doi:10.3934/dcds.2014.34.3135); Ribeiro-Junior et al. 2017 J. Fluid Mech.812, 792-814 (doi:10.1017/jfm.2016.820)). Closed orbits for irrotational waves with an opposing current and stagnation points for rotational waves were some of the issues addressed. This paper summarizes the numerical strategies adopted for capturing the flow beneath irrotational and rotational water waves...
January 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29222766/electrical-velocimetry-for-non-invasive-monitoring-of-the-closure-of-the-ductus-arteriosus-in-preterm-infants
#16
Ana Rodríguez Sánchez de la Blanca, M Sánchez Luna, N González Pacheco, M Arriaga Redondo, N Navarro Patiño
Closure of a patent ductus arteriosus (PDA) in preterm infants modifies cardiac output and induces adaptive changes in the hemodynamic situation. The present study aims to analyze those changes, through a non-invasive cardiac output monitor based on blood electrical velocimetry, in preterm babies. A prospective observational study of preterm infants with a gestational age of less than 28 weeks, and a hemodynamic significant PDA, requires intravenous ibuprofen or surgical closure. All patients were monitored with electrical velocimetry before treatment and through the following 72 h...
February 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29204456/erratum-publisher-s-note-enzyme-transient-state-kinetics-in-crystal-and-solution-from-the-perspective-of-a-time-resolved-crystallographer-struct-dyn-1-024701-2014
#17
Marius Schmidt, Dilano K Saldin
[This corrects the article DOI: 10.1063/1.4869472.].
November 2017: Structural Dynamics (Melville, N.Y.)
https://www.readbyqxmd.com/read/29203229/effects-on-hedonic-feeding-energy-expenditure-and-balance-of-the-non-opioid-peptide-dyn-a2-17
#18
B Alvarez, T Barrientos, L Gac, J A Teske, C E Perez-Leighton
The dynorphin (DYN) peptide family includes opioid and non-opioid peptides, yet the physiological role of the non-opioid DYN peptides remains poorly understood. Recent evidence shows that administering the non-opioid peptide DYN-A2-17 into the paraventricular hypothalamic nucleus (PVN) simultaneously increased short-term intake of standard rodent chow and spontaneous physical activity (SPA). The present studies aimed to expand upon the mechanisms and role of DYN-A2-17 on food intake and energy expenditure. Injection of DYN-A2-17 in PVN increased SPA, energy expenditure and wheel running in the absence of food...
December 1, 2017: Neuroscience
https://www.readbyqxmd.com/read/29200842/hemodynamic-and-gas-exchange-effects-of-inhaled-iloprost-in-patients-with-copd-and-pulmonary-hypertension
#19
Lan Wang, Yuan-Zhe Jin, Qin-Hua Zhao, Rong Jiang, Wen-Hui Wu, Su-Gang Gong, Jing He, Jin-Ming Liu, Zhi-Cheng Jing
Studies have shown that vasodilators such as iloprost can be useful for treating pulmonary hypertension (PH). However, in patients with COPD, vasodilators may inhibit hypoxic pulmonary vasoconstriction and impair gas exchange. The efficacy and safety of iloprost inhalation was assessed in 67 patients with PH associated with COPD (COPD-PH), diagnosed by right heart catheterization. Of these, 37 patients had severe PH (mean pulmonary arterial pressure [mPAP] >35 mmHg or mPAP 25-35 mmHg with low cardiac index [<2...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29190756/visualizing-the-spatiotemporal-map-of-rac-activation-in-bovine-aortic-endothelial-cells-under-laminar-and-disturbed-flows
#20
Shuai Shao, Cheng Xiang, Kairong Qin, Aziz Ur Rehman Aziz, Xiaoling Liao, Bo Liu
Disturbed flow can eliminate the alignment of endothelial cells in the direction of laminar flow, and significantly impacts on atherosclerosis in collateral arteries near the bifurcation and high curvature regions. While shear stress induced Rac polarity has been shown to play crucial roles in cell polarity and migration, little is known about the spatiotemporal map of Rac under disturbed flow, and the mechanism of flow-induced cell polarity still needs to be elucidated. In this paper, disturbed flow or laminar flow with 15 dyn/cm2 of average shear stress was applied on bovine aortic endothelial cells (BAECs) for 30 minutes...
2017: PloS One
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