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https://www.readbyqxmd.com/read/28636424/fluid-shear-stress-regulates-hepg2-cell-migration-though-time-dependent-integrin-signaling-cascade
#1
Hongchi Yu, Yang Shen, Jingsi Jin, Yingying Zhang, Tang Feng, Xiaoheng Liu
Hepatocellular carcinoma (HCC) is a subtype of malignant liver cancer with poor prognosis and limited treatment options. It is noteworthy that mechanical forces in tumor microenvironment play a pivotal role in mediating the behaviors and functions of tumor cells. As an instrumental type of mechanical forces in vivo, fluid shear stress (FSS) has been reported having potent physiologic and pathologic effects on cancer progression. However, the time-dependent mechanochemical transduction in HCC induced by FSS remains unclear...
June 21, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28620766/phenotype-transformation-of-aortic-valve-interstitial-cells-due-to-applied-shear-stresses-within-a-microfluidic-chip
#2
Xinmei Wang, Joohyung Lee, Mir Ali, Jungkyu Kim, Carla M R Lacerda
Despite valvular heart diseases constituting a significant medical problem, the acquisition of information describing their pathophysiology remains difficult. Due to valvular size, role and location within the body, there is a need for in vitro systems that can recapitulate disease onset and progression. This study combines the development of an in vitro model and its application in the mechanical stimulation of valvular cell transformation. Specifically, porcine aortic valvular interstitial cells (PAVIC) were cultured on polydimethylsiloxane microfluidic devices with or without exposure to shear stresses...
June 15, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28618563/nonmonotonic-dynamic-correlations-in-quasi-two-dimensional-confined-glass-forming-liquids
#3
Baicheng Mei, Yuyuan Lu, Lijia An, Hongfei Li, Liang Wang
It has been broadly accepted that the behavior of glass-forming liquids, where their relaxation dynamics exhibit a pronounced slowdown as they are cooled toward the glass transition temperature, is caused by the increase in one or more correlation lengths. However, the role of length scales in the dynamics of glass-forming liquids is not clearly established, and past simulation work that suggests a surprising nonmonotonic temperature evolution of spatial dynamical correlations near the mode-coupling crossover temperature has been both questioned and supported by subsequent work...
May 2017: Physical Review. E
https://www.readbyqxmd.com/read/28615744/regularity-of-non-stationary-subdivision-a-matrix-approach
#4
M Charina, C Conti, N Guglielmi, V Protasov
In this paper, we study scalar multivariate non-stationary subdivision schemes with integer dilation matrix M and present a unifying, general approach for checking their convergence and for determining their Hölder regularity (latter in the case [Formula: see text]). The combination of the concepts of asymptotic similarity and approximate sum rules allows us to link stationary and non-stationary settings and to employ recent advances in methods for exact computation of the joint spectral radius. As an application, we prove a recent conjecture by Dyn et al...
2017: Numer Math (Heidelb)
https://www.readbyqxmd.com/read/28612323/risk-assessment-and-outcomes-of-vasoplegia-after-cardiac-surgery
#5
Athanasios Tsiouris, Lynn Wilson, Ala S Haddadin, James J Yun, Abeel A Mangi
OBJECTIVE: The aim of this study was to analyze risk factors and outcomes of vasoplegia after cardiac surgery based on our experience with almost 2000 cardiac operations performed at our institution. METHODS: We retrospectively analyzed patients who underwent cardiac surgery with cardiopulmonary bypass (CPB) between 2011 and 2013. Data were available for a total of 1992 patients. We defined vasoplegia as hypotension with persistently low systemic vascular resistance (<800 dyn/s/cm) and preserved Cardiac Index (>2...
June 13, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28606099/pulmonary-hemodynamics-and-effects-of-phosphodiesterase-type-5-inhibition-in-heart-failure-a-meta-analysis-of-randomized-trials
#6
In-Chang Hwang, Yong-Jin Kim, Jun-Bean Park, Yeonyee E Yoon, Seung-Pyo Lee, Hyung-Kwan Kim, Goo-Yeong Cho, Dae-Won Sohn
BACKGROUND: Previous studies suggested that phosphodiesterase 5 inhibitors (PDE5i) have a beneficial effect in patients with heart failure (HF), although the results were inconsistent. We performed a meta-analysis to evaluate the effect of PDE5i in HF patients, and investigated the relationship between PDE5i effects and pulmonary hemodynamics. METHOD: We searched PubMed, EMBASE and the Cochrane Library for randomized controlled trials (RCTs) that compared PDE5i with placebo in HF with reduced ejection fraction (HFrEF) or HF with preserved EF (HFpEF)...
June 12, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28584226/comparison-of-3-times-a-week-4-and-5-hour-in-center-hemodialysis-sessions-with-use-of-continuous-non-invasive-hemodynamic-monitoring
#7
Łukasz Czyżewski, Janusz Wyzgał, Janusz Sierdziński, Emilia Czyżewska, Jacek Smereka, Łukasz Szarpak
BACKGROUND Very aggressive ultrafiltration rate (lasting 3.5-4 h) may result in inadequate hemodialysis (HD). Our aim was to characterize HD-induced cardiovascular adaptation and its links to fluid removal during 4- vs. 5-h HD sessions. MATERIAL AND METHODS The study involved 50 HD patients. A Cardioscreen device (Messtechnik, Ilmenau, Germany) was used to perform non-invasive hemodynamic measurements during mid-week HD sessions. Body fluids and nutritional status were assessed with a Body Composition Monitor (Fresenius Medical Care)...
June 6, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28576098/generation-of-multi-scroll-attractors-without-equilibria-via-piecewise-linear-systems
#8
R J Escalante-González, E Campos-Cantón, Matthew Nicol
In this paper, we present a new class of dynamical system without equilibria which possesses a multiscroll attractor. It is a piecewise-linear system which is simple, stable, displays chaotic behavior and serves as a model for analogous non-linear systems. We test for chaos using the 0-1 Test for Chaos from Gottwald and Melbourne [SIAM J. Appl. Dyn. Syst. 8(1), 129-145 (2009)].
May 2017: Chaos
https://www.readbyqxmd.com/read/28575332/effects-of-arterial-load-variations-on-dynamic-arterial-elastance-an-experimental-study
#9
M I Monge García, P Guijo González, M Gracia Romero, A Gil Cano, A Rhodes, R M Grounds, M Cecconi
Background.: Dynamic arterial elastance (Ea dyn ), the relationship between pulse pressure variation (PPV) and stroke volume variation (SVV), has been suggested as a functional assessment of arterial load. The aim of this study was to evaluate the impact of arterial load changes during acute pharmacological changes, fluid administration, and haemorrhage on Ea dyn . Methods.: Eighteen anaesthetized, mechanically ventilated New Zealand rabbits were studied. Arterial load changes were induced by phenylephrine ( n =9) or nitroprusside ( n =9)...
June 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28567712/cellular-fluid-shear-stress-on-implant-surfaces-establishment-of-a-novel-experimental-set-up
#10
P W Kämmerer, D G E Thiem, A Alshihri, G H Wittstock, R Bader, B Al-Nawas, M O Klein
BACKGROUND: Mechanostimuli of different cells can affect a wide array of cellular and inter-cellular biological processes responsible for dental implant healing. The purpose of this in vitro study was to establish a new test model to create a reproducible flow-induced fluid shear stress (FSS) of osteoblast cells on implant surfaces. METHODS: As FSS effects on osteoblasts are detectable at 10 dyn/cm(2), a custom-made flow chamber was created. Computer-aided verification of circulation processes was performed...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28566887/wall-shear-stress-in-portal-vein-of-cirrhotic-patients-with-portal-hypertension
#11
Wei Wei, Yan-Song Pu, Xin-Kai Wang, An Jiang, Rui Zhou, Yu Li, Qiu-Juan Zhang, Ya-Juan Wei, Bin Chen, Zong-Fang Li
AIM: To investigate wall shear stress (WSS) magnitude and distribution in cirrhotic patients with portal hypertension using computational fluid dynamics. METHODS: Idealized portal vein (PV) system models were reconstructed with different angles of the PV-splenic vein (SV) and superior mesenteric vein (SMV)-SV. Patient-specific models were created according to enhanced computed tomography images. WSS was simulated by using a finite-element analyzer, regarding the blood as a Newtonian fluid and the vessel as a rigid wall...
May 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28520793/how-does-motion-affect-gaba-measurements-order-statistic-filtering-compared-to-conventional-analysis-of-mega-press-mrs
#12
Sofie Tapper, Anders Tisell, Peter Lundberg
PURPOSE: The aim of this study was to evaluate two post-processing techniques applied to MRS MEGA-PRESS data influenced by motion-induced artifacts. In contrast to the conventional averaging technique, order statistic filtering (OSF) is a known method for artifact reduction. Therefore, this method may be suitable to incorporate in the GABA quantification. METHODS: Twelve healthy volunteers were scanned three times using a 3 T MR system. One measurement protocol consisted of two MEGA-PRESS measurements, one reference measurement and one measurement including head motions...
2017: PloS One
https://www.readbyqxmd.com/read/28501825/maternal-bradycardia-occurring-prior-to-onset-of-hellp-syndrome-in-a-woman-with-pre-eclampsia
#13
Ami Hosokawa, Takeshi Umazume, Takahiro Yamada, Hisanori Minakami
A 36-year-old nulliparous woman developed pre-eclampsia at gestational week (GW) 28(-6/7) Cardiac status was checked regularly. Heart rate of 93 beats per minute (bpm) with left atrial diameter (LAD) of 35 mm, left ventricular hypertrophy and inferior vena cava diameter (IVCD) of 8 mm at GW 32(-0/7) decreased to 48 bpm with an expanded IVCD to 25 mm, dilated left atrium (LAD to 39 mm), increased pulmonary arterial pressure, increased systemic vascular resistance (approximate 3000  dyn s/cm(5)) and biphasic intrarenal venous flow pattern 3...
May 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28501327/echo-particle-image-velocimetry-for-estimation-of-carotid-artery-wall-shear-stress-repeatability-reproducibility-and-comparison-with-phase-contrast-magnetic-resonance-imaging
#14
Arati Gurung, Phillip E Gates, Luciano Mazzaro, Jonathan Fulford, Fuxing Zhang, Alex J Barker, Jean Hertzberg, Kunihiko Aizawa, William D Strain, Salim Elyas, Angela C Shore, Robin Shandas
Measurement of hemodynamic wall shear stress (WSS) is important in investigating the role of WSS in the initiation and progression of atherosclerosis. Echo particle image velocimetry (echo PIV) is a novel ultrasound-based technique for measuring WSS in vivo that has previously been validated in vitro using the standard optical PIV technique. We evaluated the repeatability and reproducibility of echo PIV for measuring WSS in the human common carotid artery. We measured WSS in 28 healthy participants (18 males and 10 females, mean age: 56 ± 12 y)...
May 10, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28494422/cyanobacteria-blooms-before-and-during-the-restoration-process-of-a-shallow-urban-lake
#15
Joanna Rosińska, Anna Kozak, Renata Dondajewska, Ryszard Gołdyn
Swarzędzkie Lake (near Poznań) has been heavily polluted. To improve the water quality, the restoration of lake by three methods: aeration, phosphorus inactivation using small doses of iron sulphate and magnesium chloride (FeSO4 and MgCl2) and biomanipulation was initiated at the end of 2011. The aim of the present study was to determine whether sustainable restoration has a significant impact on phytoplankton, especially cyanobacterial blooms in a shallow, urban, degraded lake. Therefore, phytoplankton and the physico-chemical parameters of water at the summer thermal stratification and autumn water mixing before (2011) and during restoration (2012-2014) was studied...
May 7, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28490850/a-new-z-eigenvalue-localization-set-for-tensors
#16
Jianxing Zhao
A new Z-eigenvalue localization set for tensors is given and proved to be tighter than those in the work of Wang et al. (Discrete Contin. Dyn. Syst., Ser. B 22(1):187-198, 2017). Based on this set, a sharper upper bound for the Z-spectral radius of weakly symmetric nonnegative tensors is obtained. Finally, numerical examples are given to verify the theoretical results.
2017: Journal of Inequalities and Applications
https://www.readbyqxmd.com/read/28476408/targeted-high-resolution-quadrupole-orbitrap-mass-spectrometry-analyses-reveal-a-significant-reduction-of-tachykinin-and-opioid-neuropeptides-level-in-pc1-and-pc2-mutant-mouse-spinal-cords
#17
Mouna Saidi, Francis Beaudry
Tachykinin and opioid neuropeptides play a fundamental role in pain transmission, modulation and inhibition. The proteolysis control of endogenous tachykinin and opioid neuropeptides has a significant impact on pain perception. The role of proprotein convertases (PCs) in the proteolysis of proneuropeptides was previously established but very few studies have shown the direct impact of PCs on the regulation of specific tachykinin and opioid peptides in the central nervous system. There is an increasing interest in the therapeutic targeting of PCs for the treatment of pain but it is imperative to assess the impact of PCs on the pronociceptive and the endogenous opioid systems...
April 22, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28472330/dynomics-dynamics-of-structural-proteome-and-beyond
#18
Hongchun Li, Yuan-Yu Chang, Ji Young Lee, Ivet Bahar, Lee-Wei Yang
DynOmics (dynomics.pitt.edu) is a portal developed to leverage rapidly growing structural proteomics data by efficiently and accurately evaluating the dynamics of structurally resolved systems, from individual molecules to large complexes and assemblies, in the context of their physiological environment. At the core of the portal is a newly developed server, ENM 1.0, which permits users to efficiently generate information on the collective dynamics of any structure in PDB format, user-uploaded or database-retrieved...
May 3, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28472138/ecological-value-of-macrophyte-cover-in-creating-habitat-for-microalgae-diatoms-and-zooplankton-rotifers-and-crustaceans-in-small-field-and-forest-water-bodies
#19
Sofia Celewicz-Gołdyn, Natalia Kuczyńska-Kippen
Due to their small area and shallow depth ponds are usually treated as a single sampling unit, while various microhabitats offer different environmental conditions. Thus, we tested the effect of different habitat types typically found within small ponds on the microalgae and zooplankton communities. We found that submerged macrophytes have the strongest impact on microalgae and zooplankton communities out of all the analysed habitats. Some epontic diatoms (e.g. Fragilaria dilatata, Cymbella affinis) and littoral-associated zooplankton species (e...
2017: PloS One
https://www.readbyqxmd.com/read/28464209/alanine-scan-of-the-opioid-peptide-dynorphin-b-amide
#20
Anand A Joshi, Thomas F Murray, Jane V Aldrich
To date structure-activity relationship (SAR) studies of the dynorphins (Dyn), endogenous peptides for kappa opioid receptors (KOR), have focused almost exclusively on Dyn A with minimal studies on Dyn B. While both Dyn A and Dyn B have identical N-terminal sequences, their C-terminal sequences differ which could result in differences in pharmacological activity. We performed an alanine scan of the non-glycine residues up through residue 11 of Dyn B amide to explore the role of these side chains in the activity of Dyn B...
May 2, 2017: Biopolymers
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