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https://www.readbyqxmd.com/read/29669016/hemodynamic-response-to-fluid-removal-during-hemodialysis-categorization-of-causes-of-intradialytic-hypotension
#1
Nathan W Levin, Marcia H F G de Abreu, Lucas E Borges, Helcio A Tavares Filho, Rabia Sarwar, Surendra Gupta, Tahir Hafeez, Shaul Lev, Caroline Williams
Background: Intradialytic hypotension is a clinically significant problem, however, the hemodynamics that underlie ultrafiltration and consequent hypotensive episodes has not been studied comprehensively. Methods: Intradialytic cardiac output, cardiac power and peripheral resistance changes from pretreatment measurements were evaluated using a novel regional impedance cardiographic device (NICaS, NI Medical, Peta Tikva, Israel) in 263 hemodialysis sessions in 54 patients in dialysis units in the USA and Brazil with the goal of determining the various hemodynamic trends as blood pressure decreases...
April 14, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29624063/diastereoselective-synthesis-of-a-dyn-3-arene-with-distinct-binding-behaviors-toward-linear-biogenic-polyamines
#2
Marion Donnier-Maréchal, Jean Septavaux, Emeric Jeamet, Alexandre Héloin, Florent Perret, Elise Dumont, Jean-Christophe Rossi, Fabio Ziarelli, Julien Leclaire, Laurent Vial
The extension of the family of dyn[ n]arenes toward a three-membered macrocycle is reported. Through a templated approach, a single diastereoisomer of a dyn[3]arene that bears six carboxyl groups could be isolated by precipitation in 59-63% yield and excellent purity (≥95%). A combination of experimental and computational experiments in water at physiological pH revealed that the macrocycle could bind parent biogenic polyamines with a unique diversity of surface-binding modes. Whereas no binding event could be accurately measured with 1,3-diaminopropane, spermidine formed a classical stoichiometric complex with the dyn[3]arene in the millimolar concentration range...
April 6, 2018: Organic Letters
https://www.readbyqxmd.com/read/29621271/comprehensive-haematological-indices-reference-intervals-for-a-healthy-omani-population-first-comprehensive-study-in-gulf-cooperation-council-gcc-and-middle-eastern-countries-based-on-age-gender-and-abo-blood-group-comparison
#3
Adhra Al-Mawali, Avinash Daniel Pinto, Raiya Al-Busaidi, Rabab H Al-Lawati, Magdi Morsi
BACKGROUND: Reference intervals for venous blood parameters differs with age, gender, geographic region, and ethnic groups. Hence local laboratory reference intervals are important to improve the diagnostic accuracy of health assessments and diseases. However, there have been no comprehensive published reference intervals established in Oman, the Gulf Cooperation Council or Middle Eastern countries. Hence, the aim of this study was to establish reference intervals for full blood count in healthy Omani adults...
2018: PloS One
https://www.readbyqxmd.com/read/29609502/fluid-shear-stress-promotes-osteoblast-proliferation-through-the-nfatc1-erk5-pathway
#4
Ning Ding, Bin Geng, Zhonghao Li, Quanzeng Yang, Liang Yan, Lang Wan, Bo Zhang, Cuifang Wang, Yayi Xia
PURPOSE: Extracellular signal regulated kinase 5 (ERK5) is thought to regulate osteoblast proliferation. To further understand how ERK5 signalling regulates osteoblast proliferation induced by fluid shear stress (FSS), we examined some potential signalling targets associated with ERK5 in MC3T3-E1 cells. METHODS: MC3T3-E1 cells were treated with XMD8-92 (an ERK5 inhibitor) or Cyclosporin A (CsA, a Nuclear Factor of Activated T Cells (NFAT) c1 inhibitor) and/or exposed to 12 dyn/cm2 FSS...
April 3, 2018: Connective Tissue Research
https://www.readbyqxmd.com/read/29604647/reconstructing-latent-dynamical-noise-for-better-forecasting-observables
#5
Yoshito Hirata
I propose a method for reconstructing multi-dimensional dynamical noise inspired by the embedding theorem of Muldoon et al. [Dyn. Stab. Syst. 13, 175 (1998)] by regarding multiple predictions as different observables. Then, applying the embedding theorem by Stark et al. [J. Nonlinear Sci. 13, 519 (2003)] for a forced system, I produce time series forecast by supplying the reconstructed past dynamical noise as auxiliary information. I demonstrate the proposed method on toy models driven by auto-regressive models or independent Gaussian noise...
March 2018: Chaos
https://www.readbyqxmd.com/read/29571233/blood-lactate-accumulation-during-competitive-freediving-and-synchronized-swimming
#6
Lara RodrÍguez-Zamora, Harald K Engan, Angelica Lodin-Sundström, Fanny Schagatay, Xavier Iglesias, Ferran A Rodríguez, Erika Schagatay
A number of competitive water sports are performed while breath-holding (apnea). Such performances put large demands on the anaerobic system, but the study of lactate accumulation in apneic sports is limited. We therefore aimed to determine and compare the net lactate accumulation (NLA) during competition events in six disciplines of competitive freediving (FD) and three disciplines of synchronized swimming (SSW). The FD disciplines were: static apnea (STA; n = 14); dynamic apnea (DYN; n = 19); dynamic apnea no fins (DNF; n = 16); constant weight (CWT; n = 12); constant weight no fins (CNF; n = 8); free immersion (FIM; n =10)...
January 2018: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29488533/flow-dynamics-control-endothelial-permeability-in-a-microfluidic-vessel-bifurcation-model
#7
Ehsan Akbari, Griffin B Spychalski, Kaushik K Rangharajan, Shaurya Prakash, Jonathan W Song
Endothelial barrier function is known to be regulated by a number of molecular mechanisms; however, the role of biomechanical signals associated with blood flow is comparatively less explored. Biomimetic microfluidic models comprised of vessel analogues that are lined with endothelial cells (ECs) have been developed to help answer several fundamental questions in endothelial mechanobiology. However, previously described microfluidic models have been primarily restricted to single straight or two parallel vessel analogues, which do not model the bifurcating vessel networks typically present in physiology...
February 28, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29483764/erythrocyte-aggregation-and-blood-viscosity-is-similar-in-homozygous-sickle-cell-disease-patients-with-and-without-leg-ulcers
#8
Andre S A Bowers, Walworth W Duncan, D J Pepple
Background  There is no consensus regarding the role of red blood cell (RBC) aggregation in the pathogenesis of leg ulcers (LUs) in sickle cell disease (SCD). Objectives  We sought to evaluate whether the cross-sectional determination of RBC aggregation and hematological indices were associated with the presence of LU in homozygous SCD. Methods  Twenty-seven patients with LU and 23 with no history of ulceration were recruited into the study. A laser-assisted rotational red cell analyzer (LoRRca) was used in the determination of the aggregation index (AI), aggregation half-time ( t 1/2 ), and the RBC aggregate strength (AMP)...
March 2018: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/29479048/generic-selection-criteria-for-safety-and-patient-benefit-vii-comparing-the-physicochemical-and-pharmaceutical-properties-of-brand-name-and-generic-terbinafine-hydrochloride-cream
#9
Mitsuru Nozawa, Miho Goto, Yuko Wada, Miyuki Kumazawa, Ken-Ichi Shimokawa, Fumiyoshi Ishii
We measured and compared the physicochemical properties (pH, yield value, and squeeze force) of a drug for dermatomycosis, terbinafine hydrochloride-containing cream (brand-name product), and 12 generic products to clarify the characteristics of each product. On pH measurement, the pH value of the brand-name product, Lamisil, was 4.8, and those of the generic products ranged from 4.3 to 5.5, showing no marked difference. Furthermore, the yield value of Lamisil, as an index of cream ductility, was 122.2 dyn/cm2 , and those of the generic products ranged from 42...
February 25, 2018: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/29479004/neurokinin-b-receptor-agonist-and-dynorphin-receptor-antagonist-stimulated-luteinizing-hormone-secretion-in-fasted-male-rodents
#10
Toshiya Matsuzaki, Altankhuu Tungalagsuvd, Munkhsaikhan Munkhzaya, Takeshi Iwasa, Kiyohito Yano, Yiliyasi Mayila, Takako Tokui, Rie Yanagihara, Sumika Matsui, Takeshi Kato, Akira Kuwahara, Minoru Irahara
Kisspeptin/neurokinin B (NKB)/dynorphin (Dyn) (KNDy) neuron in hypothalamic arcuate nucleus plays a key role in GnRH/LH pulsatile secretion. We aimed to determine whether stimulation of NKB/neurokinin 3 receptor (NK3R) signaling and inhibition of Dyn/kappa-opioid receptor (KOR) signaling recover LH secretion that is suppressed by acute fasting in male rats. Furthermore, we determined dose dependent effect of NKB/NK3R signaling on serum LH level under acute fasting condition in male mice. Mature male rats were injected saline (0...
February 23, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29478320/combinatorial-in-vitro-and-in-silico-approach-to-describe-shear-force-dependent-uptake-of-nanoparticles-in-microfluidic-vascular-models
#11
Verena Charwat, Isabel Olmos Calvo, Mario Rothbauer, Sebastian Rudi Adam Kratz, Christian Jungreuthmayer, Jürgen Zanghellini, Johannes Grillari, Peter Ertl
In the present work, we combine experimental and computational methods to define the critical shear stress as an alternative parameter for nanotoxicological and nanomedical evaluations using an in vitro microfluidic vascular model. We demonstrate that our complementary in vitro and in silico approach is well suited to assess the fluid flow velocity above which clathrin-mediated (active) nanoparticle uptake per cell decreases drastically although higher numbers of nanoparticles per cell are introduced. Results of our study revealed a critical shear stress of 1...
February 28, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29460403/effects-of-ivabradine-on-endothelial-function-aortic-properties-and-ventricular-arterial-coupling-in-chronic-systolic-heart-failure-patients
#12
Ivano Bonadei, Edoardo Sciatti, Enrico Vizzardi, Davide Fabbricatore, Mattia Pagnoni, Laura Rossi, Valentina Carubelli, Carlo M Lombardi, Marco Metra
AIM: Heart rate (HR) is an important prognostic factor in patients affected by chronic heart failure (CHF); ivabradine has been demonstrated to significantly reduce nonfatal myocardial infarction and hospitalization rate for acute heart failure and to improve left ventricular (LV) reverse remodeling, quality of life, exercise capacity, and arterial elastance (Ea) in these patients. We aimed at evaluating the short-term effects of ivabradine on ventricular-arterial coupling (VAC), aortic stiffness, and endothelial function in stable patients with CHF...
February 20, 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29458877/1p-deletion-syndrome-a-prenatal-diagnosis-characterized-by-an-abnormal-1st-trimester-combined-screening-test-yet-a-normal-nipt-result
#13
Chung-Yuan Yang, Chuan-Chi Kao, Shuenn-Dyn Chang, Shih-Yin Huang
OBJECTIVE: To present a case with prenatal diagnosis and cytogenetic characterization of 1p36 deletion syndrome whose first trimester combined testing is abnormal but a normal NIPT result. CASE REPORT: A 33-year-old had an abnormal 1st trimester fetal aneuploidy screening result, but no trisomies 13, 18, 21 were detected by the noninvasive prenatal testing. Amniocentesis was performed after ultrasound showed fetal ventriculomegaly and echogenic bowel. The final conventional cytogenetics revealed a karyotype of 46, XX, del(1)(p36)...
February 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29452568/primary-cilia-regulated-transcriptome-in-the-renal-collecting-duct
#14
Sami G Mohammed, Francisco J Arjona, Eric H J Verschuren, Zeineb Bakey, Wynand Alkema, Sacha van Hijum, Miriam Schmidts, René J M Bindels, Joost G J Hoenderop
Renal tubular cells respond to mechanical stimuli generated by urinary flow to regulate the activity and transcript abundance of important genes for ion handling, cellular homeostasis, and proper renal development. The primary cilium, a mechanosensory organelle, is postulated to regulate this mRNA response. The aim of this study is to reveal the transcriptome changes of tubular epithelia in response to fluid flow and determine the role of primary cilia in this process. Inner-medullary collecting duct (CD) cells were subjected to either static or physiologically relevant fluid flow (∼0...
February 8, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29414505/inter-operator-variability-in-compartmental-kinetic-analysis-of-18f-fluoromisonidazole-dynamic-pet
#15
Sadek A Nehmeh, Jazmin Schwartz, Milan Grkovski, Ivan Yeung, Charles M Laymon, Mark Muzi, John L Humm
PURPOSE: To assess the inter-operator variability in compartment analysis (CA) of dynamic-FMISO (dyn-FMISO) PET. METHODS: Study-I: Five investigators conducted CA for 23 NSCLC dyn-FMISO tumor time-activity-curves. Study-II: Four operators performed CA for four NSCLC dyn-FMISO datasets. Repeatability of Kinetic-Rate-Constants (KRCs) was assessed. RESULTS: Study-I: Strong correlation (ICC > 0.9) and interchangeable results among operators existed for all KRCs...
January 12, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29405326/hemodynamic-effects-of-connection-to-continuous-renal-replacement-therapy-in-a-pediatric-animal-model
#16
Sarah Nicole Fernández Lafever, Maria Jose Santiago, Jorge López, Rafael González, María José Solana, Javier Urbano, Jesus Lopez-Herce
To assess the hemodynamic effects of connection to continuous renal replacement therapy (CRRT) in a pediatric experimental animal model. Prospective experimental study was performed using piglets between 2 and 3 months of age and 9-11 kg. CRRT with a PrismaflexR monitor and HF20 filter (surface of 0.2 m2 ) was started after monitoring and anesthetic induction with an initial blood flow at 20 mL/min with 10 mL/min increases every minute until the goal flow of 5 mL/kg/min was achieved. Heart rate, blood pressure, central venous pressure, cardiac index, and renal blood flow were registered at baseline, 5, 15, 30, 60, 120, 180, 240, and 360 min...
February 6, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29393580/bosentan-therapy-for-pulmonary-arterial-hypertension-and-chronic-thromboembolic-pulmonary-hypertension-a-systemic-review-and-meta-analysis
#17
Xinwang Chen, Zhenguo Zhai, Ke Huang, Wanmu Xie, Jun Wan, Chen Wang
BACKGROUND AND OBJECTIVE: Bosentan therapy has been recommended for pulmonary arterial hypertension (PAH) and might be beneficial for chronic thromboembolic pulmonary hypertension (CTEPH). We aimed to evaluate the specific effects of bosentan for PAH and CTEPH. MATERIALS AND METHODS: We performed a systemic review and meta-analysis of randomized controlled trials (RCTs), comparing efficacy and safety of bosentan treatment for PAH and CTEPH through major biomedical database...
February 2, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29383684/dynorphin-and-%C3%AE%C2%BA-opioid-receptor-dysregulation-in-the-dopaminergic-reward-system-of-human-alcoholics
#18
Igor Bazov, Daniil Sarkisyan, Olga Kononenko, Hiroyuki Watanabe, Tatiana Yakovleva, Anita C Hansson, Wolfgang H Sommer, Rainer Spanagel, Georgy Bakalkin
Molecular changes induced by excessive alcohol consumption may underlie formation of dysphoric state during acute and protracted alcohol withdrawal which leads to craving and relapse. A main molecular addiction hypothesis is that the upregulation of the dynorphin (DYN)/κ-opioid receptor (KOR) system in the nucleus accumbens (NAc) of alcohol-dependent individuals causes the imbalance in activity of D1- and D2 dopamine receptor (DR) expressing neural circuits that results in dysphoria. We here analyzed post-mortem NAc samples of human alcoholics to assess changes in prodynorphin (PDYN) and KOR (OPRK1) gene expression and co-expression (transcriptionally coordinated) patterns...
January 30, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29374922/-effects-of-application-of-pulse-contour-cardiac-output-monitoring-technology-in-early-treatment-of-patients-with-large-area-burns
#19
D Y Wang, W G Xie, M M Xi, Z Li, B Wang
Objective: To analyze the changes and relationship of early hemodynamic indexes of patients with large area burns monitored by pulse contour cardiac output (PiCCO) monitoring technology, so as to assess the guiding value of this technology in the treatment of patients with large area burns during shock period. Methods: Eighteen patients with large area burns, confirming to the study criteria, were admitted to our unit from May 2016 to May 2017. Pulse contour cardiac output index (PCCI), systemic vascular resistance index (SVRI), global end-diastolic volume index (GEDVI), and extravascular lung water index (EVLWI) of patients were monitored by PiCCO instrument from admission to post injury day (PID) 7, and they were calibrated and recorded once every four hours...
January 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29352448/mesenchymal-stem-cell-deformability-and-implications-for-microvascular-sequestration
#20
Herbert H Lipowsky, Daniel T Bowers, Brittany L Banik, Justin L Brown
Mesenchymal stem cells (MSCs) have received considerable attention in regenerative medicine, particularly in light of prospects for targeted delivery by intra-arterial injection. However, little is known about the mechanics of MSC sequestration in the microvasculature and the yield pressure (PY ), above which MSCs will pass through microvessels of a given diameter. The objectives of the current study were to delineate the dependency of PY on cell size and the heterogeneity of cell mechanical properties and diameters (DCELL ) of cultured MSCs...
April 2018: Annals of Biomedical Engineering
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