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https://www.readbyqxmd.com/read/28821572/rolling-neutrophils-form-tethers-and-slings-under-physiologic-conditions-in-vivo
#1
Alex Marki, Konrad Buscher, Zbigniew Mikulski, Axel Pries, Klaus Ley
Human and mouse neutrophils are known to form tethers when rolling on selectins in vitro. Tethers are ∼0.2 μm thin, ∼5-10 μm-long structures behind rolling cells that can swing around to form slings that serve as self-adhesive substrates. Here, we developed a mouse intravital imaging method, where the neutrophil surface is labeled by injecting fluorescently labeled mAb to Ly-6G. Venules in the cremaster muscle of live mice were imaged at a high frame rate using a confocal microscope equipped with a fast resonant scanner...
August 18, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28815701/lincrna-dyn-lrb2-2-upregulates-cholesterol-efflux-by-decreasing-tlr2-expression-in-macrophages
#2
Yongqiang Li, Shuxin Shen, Shoukun Ding, Lixia Wang
OBJECTIVE: This study is designed to determine whether lincRNA-DYNLRB2-2 could promote cholesterol efflux through regulating the expression of TLR2. METHODS: THP-1 and RAW264.7 cells were incubated with oxLDL for 48 h to induce the formation of foam cells, and ORO staining was performed and intracellular cholesterol contents were measured by HPLC assay. qRT-PCR and Western blotting were performed to detect mRNA and protein expression levels, respectively. Lentiviral vector LV-DYNLRB2-2 and lincRNA-DYNLRB2-2 siRNA was constructed to explore its potential role...
August 16, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28802836/neocortical-prodynorphin-expression-is-transiently-increased-with-learning-implications-for-time-and-learning-dependent-neocortical-kappa-opioid-receptor-activation
#3
Ryan Loh, Sean Collins, Roberto Galvez
There are several lines of evidence that indicate a prominent role for the opioid system in the acquisition and consolidation of learned associations. Specifically, kappa opioid receptor (KOR) modulation has been demonstrated to alter various behavioral tasks including whisker trace eyeblink conditioning (WTEB). WTEB is an associative conditioning paradigm in which a neutral conditioned stimulus (CS; Whisker stimulation) is paired following a short stimulus free trace interval with a salient unconditioned stimulus that elicits a blink response (US; Eye shock)...
August 9, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28800500/sb223412-a-neurokinin-3-receptor-selective-antagonist-suppresses-testosterone-secretion-in-male-guinea-pigs
#4
Sho Nakamura, Yoshiko Ito, Koki Yamamoto, Chudai Takahashi, Mingdao Dai, Miyu Tanahashi, Yoshihisa Uenoyama, Hiroko Tsukamura, Shinya Oishi, Kei-Ichiro Maeda, Fuko Matsuda
Guinea pigs are important zoo animals and have been recommended for animal-assisted activities or therapy, however there are problems concerning testosterone inducing aggressive or sexual behaviors in male guinea pigs. Testicular testosterone secretion is regulated by pulsatile gonadotropin releasing hormone (GnRH)/luteinizing hormone (LH) release in mammals. The mechanism generating GnRH/LH pulses is thought to be governed by kisspeptin neurons, which coexpress neurokinin B (NKB) and dynorphin A (Dyn), in the arcuate nucleus (ARC)...
July 31, 2017: Theriogenology
https://www.readbyqxmd.com/read/28790546/effect-of-cigarette-smoking-on-haematological-parameters-in-healthy-population
#5
Maja Malenica, Besim Prnjavorac, Tamer Bego, Tanja Dujic, Sabina Semiz, Selma Skrbo, Amar Gusic, Ajla Hadzic, Adlija Causevic
OBJECTIVE: Tobacco cigarette smoking is one of the major leading causes of death throughout the world. Smoking has both acute and chronic effect on haematological parameters. The aim of the present study was to assess the extent of adverse effects of cigarette smoking on biochemical characteristics in healthy smokers. SUBJECTS AND METHOD: One hundred and fifty six subjects participated in this study, 56 smokers and 100 non-smokers. The smokers were regularly consuming 10-20 cigarettes per day for at least 3 years...
April 2017: Medical Archives
https://www.readbyqxmd.com/read/28764399/fire-ice-water-and-dirt-a-simple-climate-model
#6
John Kroll
A simple paleoclimate model was developed as a modeling exercise. The model is a lumped parameter system consisting of an ocean (water), land (dirt), glacier, and sea ice (ice) and driven by the sun (fire). In comparison with other such models, its uniqueness lies in its relative simplicity yet yielding good results. For nominal values of parameters, the system is very sensitive to small changes in the parameters, yielding equilibrium, steady oscillations, and catastrophes such as freezing or boiling oceans...
July 2017: Chaos
https://www.readbyqxmd.com/read/28726252/central-amygdala-relaxin-3-rxfp3-signalling-modulates-alcohol-seeking-in-rats
#7
Leigh C Walker, Hanna E Kastman, Elena Krstew, Andrew L Gundlach, Andrew J Lawrence
BACKGROUND AND PURPOSE: Alcohol use disorders are a leading cause of preventable deaths worldwide and stress is a major trigger of relapse. The neuropeptide relaxin-3 and its cognate receptor, relaxin family peptide receptor 3 (RXFP3), modulate stress-induced relapse to alcohol seeking in rats and while the bed nucleus of the stria terminalis has been implicated in this regard, the central nucleus of the amygdala (CeA) also receives a relaxin-3 innervation and CeA neurons densely express RXFP3 mRNA...
July 20, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28725886/dependence-of-homogeneous-crystal-nucleation-in-water-droplets-on-their-radii-and-its-implication-for-modeling-the-formation-of-ice-particles-in-cirrus-clouds
#8
Yuri S Djikaev, Eli Ruckenstein
We propose an approximation for the total ice nucleation rate J = J(T,R) in supercooled water droplets as a function of both droplet radius R and temperature T, taking into account both volume-based and surface-stimulated nucleation modes. Its crucial idea is that even in the surface-stimulated mode crystal nuclei initially emerge (as sub-critical clusters) homogeneously in the sub-surface layer, not "pseudo-heterogeneously" at the surface. This mode is negligible in large droplets, but becomes increasingly important with decreasing droplet size and is dominant in small droplets...
July 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28694726/a-nationwide-multicentre-study-in-turkey-for-establishing-reference-intervals-of-haematological-parameters-with-novel-use-of-a-panel-of-whole-blood
#9
Yesim Ozarda, Kiyoshi Ichihara, Ebubekir Bakan, Harun Polat, Nurinnisa Ozturk, Nurcan K Baygutalp, Fatma Taneli, Yesim Guvenc, Murat Ormen, Zubeyde Erbayraktar, Nurten Aksoy, Hatice Sezen, Meltem Demir, Gulcin Eskandari, Gurbuz Polat, Nuriye Mete, Hatice Yuksel, Husamettin Vatansev, Fatma Gun, Okhan Akin, Ozlem Ceylan, Tevfik Noyan, Ozgul Gozlukaya, Yuksel Aliyazicioglu, Sevim Kahraman, Melahat Dirican, Gul Ozlem Tuncer, Shogo Kimura, Pinar Eker
INTRODUCTION: A nationwide multicentre study was conducted to establish well-defined reference intervals (RIs) of haematological parameters for the Turkish population in consideration of sources of variation in reference values (RVs). MATERIALS AND METHODS: K2-EDTA whole blood samples (total of 3363) were collected from 12 laboratories. Sera were also collected for measurements of iron, UIBC, TIBC, and ferritin for use in the latent abnormal values exclusion (LAVE) method...
June 15, 2017: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/28694723/does-recreational-scuba-diving-have-clinically-significant-effect-on-routine-haematological-parameters
#10
Antonija Perovic, Nora Nikolac, Marina Njire Braticevic, Ana Milcic, Sandra Sobocanec, Tihomir Balog, Sanja Dabelic, Jerka Dumic
INTRODUCTION: Scuba diving represents a combination of exercise and changes in environmental conditions. This study aimed to evaluate changes in haematological parameters after recreational scuba diving in order to identify clinically significant changes. MATERIALS AND METHODS: The study included males, 17 recreational divers, median age (range) 41 (30-52) years. Blood samples were taken before diving, immediately after diving to 30 meters for 30 minutes, 3 hours and 6 hours after diving...
June 15, 2017: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/28680255/two-s-type-z-eigenvalue-inclusion-sets-for-tensors
#11
Yanan Wang, Gang Wang
In this paper, we present two S-type Z-eigenvalue inclusion sets involved with a nonempty proper subset S of N for general tensors. It is shown that the new sets are tighter than those provided by Wang et al. (Discrete Contin. Dyn. Syst., Ser. B 22(1):187-198, 2017). Furthermore, we obtain upper bounds for the spectral radius of weakly symmetric nonnegative tensors, which are sharper than existing results.
2017: Journal of Inequalities and Applications
https://www.readbyqxmd.com/read/28662184/corneal-epithelial-cells-exposed-to-shear-stress-show-altered-cytoskeleton-and-migratory-behaviour
#12
Sara Molladavoodi, Matthew Robichaud, David Wulff, Maud Gorbet
Cells that form the corneal epithelium, the outermost layer of the cornea, are exposed to shear stress through blinking during waking hours. In this in vitro study, the effect of fluid shear stress on human corneal epithelial cells (HCECs) was investigated. Following exposure to shear stresses of 4 and 8 dyn/cm2, HCECs showed cytoskeletal rearrangement with more prominent, organized and elongated filamentous actin. Cytoskeletal changes were time-dependent, and were most significant after 24 hours of shear stress...
2017: PloS One
https://www.readbyqxmd.com/read/28636424/fluid-shear-stress-regulates-hepg2-cell-migration-though-time-dependent-integrin-signaling-cascade
#13
Hongchi Yu, Yang Shen, Jingsi Jin, Yingying Zhang, Tang Feng, Xiaoheng Liu
Hepatocellular carcinoma (HCC) is a subtype of malignant liver cancer with poor prognosis and limited treatment options. It is noteworthy that mechanical forces in tumor microenvironment play a pivotal role in mediating the behaviors and functions of tumor cells. As an instrumental type of mechanical forces in vivo, fluid shear stress (FSS) has been reported having potent physiologic and pathologic effects on cancer progression. However, the time-dependent mechanochemical transduction in HCC induced by FSS remains unclear...
June 21, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28620766/phenotype-transformation-of-aortic-valve-interstitial-cells-due-to-applied-shear-stresses-within-a-microfluidic-chip
#14
Xinmei Wang, Joohyung Lee, Mir Ali, Jungkyu Kim, Carla M R Lacerda
Despite valvular heart diseases constituting a significant medical problem, the acquisition of information describing their pathophysiology remains difficult. Due to valvular size, role and location within the body, there is a need for in vitro systems that can recapitulate disease onset and progression. This study combines the development of an in vitro model and its application in the mechanical stimulation of valvular cell transformation. Specifically, porcine aortic valvular interstitial cells (PAVIC) were cultured on polydimethylsiloxane microfluidic devices with or without exposure to shear stresses...
June 15, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28618563/nonmonotonic-dynamic-correlations-in-quasi-two-dimensional-confined-glass-forming-liquids
#15
Baicheng Mei, Yuyuan Lu, Lijia An, Hongfei Li, Liang Wang
It has been broadly accepted that the behavior of glass-forming liquids, where their relaxation dynamics exhibit a pronounced slowdown as they are cooled toward the glass transition temperature, is caused by the increase in one or more correlation lengths. However, the role of length scales in the dynamics of glass-forming liquids is not clearly established, and past simulation work that suggests a surprising nonmonotonic temperature evolution of spatial dynamical correlations near the mode-coupling crossover temperature has been both questioned and supported by subsequent work...
May 2017: Physical Review. E
https://www.readbyqxmd.com/read/28615744/regularity-of-non-stationary-subdivision-a-matrix-approach
#16
M Charina, C Conti, N Guglielmi, V Protasov
In this paper, we study scalar multivariate non-stationary subdivision schemes with integer dilation matrix M and present a unifying, general approach for checking their convergence and for determining their Hölder regularity (latter in the case [Formula: see text]). The combination of the concepts of asymptotic similarity and approximate sum rules allows us to link stationary and non-stationary settings and to employ recent advances in methods for exact computation of the joint spectral radius. As an application, we prove a recent conjecture by Dyn et al...
2017: Numer Math (Heidelb)
https://www.readbyqxmd.com/read/28612323/risk-assessment-and-outcomes-of-vasoplegia-after-cardiac-surgery
#17
Athanasios Tsiouris, Lynn Wilson, Ala S Haddadin, James J Yun, Abeel A Mangi
OBJECTIVE: The aim of this study was to analyze risk factors and outcomes of vasoplegia after cardiac surgery based on our experience with almost 2000 cardiac operations performed at our institution. METHODS: We retrospectively analyzed patients who underwent cardiac surgery with cardiopulmonary bypass (CPB) between 2011 and 2013. Data were available for a total of 1992 patients. We defined vasoplegia as hypotension with persistently low systemic vascular resistance (<800 dyn/s/cm) and preserved Cardiac Index (>2...
June 13, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28606099/pulmonary-hemodynamics-and-effects-of-phosphodiesterase-type-5-inhibition-in-heart-failure-a-meta-analysis-of-randomized-trials
#18
In-Chang Hwang, Yong-Jin Kim, Jun-Bean Park, Yeonyee E Yoon, Seung-Pyo Lee, Hyung-Kwan Kim, Goo-Yeong Cho, Dae-Won Sohn
BACKGROUND: Previous studies suggested that phosphodiesterase 5 inhibitors (PDE5i) have a beneficial effect in patients with heart failure (HF), although the results were inconsistent. We performed a meta-analysis to evaluate the effect of PDE5i in HF patients, and investigated the relationship between PDE5i effects and pulmonary hemodynamics. METHOD: We searched PubMed, EMBASE and the Cochrane Library for randomized controlled trials (RCTs) that compared PDE5i with placebo in HF with reduced ejection fraction (HFrEF) or HF with preserved EF (HFpEF)...
June 12, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28584226/comparison-of-3-times-a-week-4-and-5-hour-in-center-hemodialysis-sessions-with-use-of-continuous-non-invasive-hemodynamic-monitoring
#19
Łukasz Czyżewski, Janusz Wyzgał, Janusz Sierdziński, Emilia Czyżewska, Jacek Smereka, Łukasz Szarpak
BACKGROUND Very aggressive ultrafiltration rate (lasting 3.5-4 h) may result in inadequate hemodialysis (HD). Our aim was to characterize HD-induced cardiovascular adaptation and its links to fluid removal during 4- vs. 5-h HD sessions. MATERIAL AND METHODS The study involved 50 HD patients. A Cardioscreen device (Messtechnik, Ilmenau, Germany) was used to perform non-invasive hemodynamic measurements during mid-week HD sessions. Body fluids and nutritional status were assessed with a Body Composition Monitor (Fresenius Medical Care)...
June 6, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28576098/generation-of-multi-scroll-attractors-without-equilibria-via-piecewise-linear-systems
#20
R J Escalante-González, E Campos-Cantón, Matthew Nicol
In this paper, we present a new class of dynamical system without equilibria which possesses a multiscroll attractor. It is a piecewise-linear system which is simple, stable, displays chaotic behavior and serves as a model for analogous non-linear systems. We test for chaos using the 0-1 Test for Chaos from Gottwald and Melbourne [SIAM J. Appl. Dyn. Syst. 8(1), 129-145 (2009)].
May 2017: Chaos
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