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https://www.readbyqxmd.com/read/28927765/recurrent-vulvovaginal-candidiasis
#1
REVIEW
Freida Blostein, Elizabeth Levin-Sparenberg, Julian Wagner, Betsy Foxman
PURPOSE: Recurrent vulvovaginal candidiasis (RVVC), multiple episodes of vulvovaginal candidiasis (VVC; vaginal yeast infection) within a 12-month period, adversely affects quality of life, mental health, and sexual activity. Diagnosis is not straightforward, as VVC is defined by the combination of often nonspecific vaginal symptoms and the presence of yeast-which is a common vaginal commensal. Estimating the incidence and prevalence is challenging: most VVC is diagnosed and treated empirically, the availability for purchase of effective therapies over the counter enables self-diagnosis and treatment, and the duration of the relatively benign VVC symptoms is short, introducing errors into any estimates relying on medical records or patient recall...
August 15, 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/28927382/a-rapid-seamless-method-for-gene-knockout-in-pseudomonas-aeruginosa
#2
Weiliang Huang, Angela Wilks
BACKGROUND: Pseudomonas aeruginosa is a model organism for the study of quorum sensing, biofilm formation, and also leading cause of nosocomial infections in immune compromised patients. As such P. aeruginosa is one of the most well studied organisms in terms of its genetics. However, the construction of gene deletions and replacements in Pseudomonas aeruginosa is relatively time-consuming, requiring multiple steps including suicide vector construction, conjugation, inactivation with insertion of antibiotic resistance cassettes and allelic exchange...
September 19, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28925091/counting-the-cost-of-over-the-counter-codeine-containing-analgesic-misuse-a-retrospective-review-of-hospital-admissions-over-a-5-year-period
#3
Deanna Mill, Jacinta L Johnson, Victoria Cock, Emily Monaghan, Elizabeth D Hotham
INTRODUCTION AND AIMS: Combination analgesics containing codeine (CACC) are currently available over-the-counter (OTC) in many countries following a pharmacist's advice. Published case reports detail life-threatening morbidities associated with OTC-CACC misuse, although the cost of treating such patients has not been quantified. This study aims to: (i) identify and detail patients admitted to an Australian tertiary teaching hospital over a 5 year period with sequelae of OTC-CACC misuse; and (ii) estimate the costs of identified hospital admissions...
September 18, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28922504/selective-remodeling-of-glutamatergic-transmission-to-striatal-cholinergic-interneurons-after-dopamine-depletion
#4
Jose de Jesus Aceves Buendia, Lior Tiroshi, Wei-Hua Chiu, Joshua A Goldberg
The widely-held view that the pathophysiology of Parkinson's disease arises from an under-activation of the direct pathway striatal spiny neurons (dSPNs) has gained support from a recently described weakening of the glutamatergic projection from the parafascicular nucleus (PfN) to dSPNs in experimental parkinsonism. However, the impact of the remodeling of the thalamostriatal projection cannot be fully appreciated without considering its impact on cholinergic interneurons (ChIs) that themselves preferentially activate indirect pathway spiny neurons (iSPNs)...
September 18, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28916555/first-person-seth-zimmerman
#5
(no author information available yet)
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Seth Zimmerman is the first author on 'Cells lay their own tracks - optogenetic Cdc42 activation stimulates fibronectin deposition supporting directed migration', published in Journal of Cell Science. Seth completed the work in this article as a PhD student under the supervision of Jim Bear and Brian Kuhlman at University of North Carolina at Chapel Hill, USA...
September 15, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28915277/a-portable-bioelectronic-sensing-system-bessy-for-environmental-deployment-incorporating-differential-microbial-sensing-in-miniaturized-reactors
#6
Alyssa Y Zhou, Moshe Baruch, Caroline M Ajo-Franklin, Michel M Maharbiz
Current technologies are lacking in the area of deployable, in situ monitoring of complex chemicals in environmental applications. Microorganisms metabolize various chemical compounds and can be engineered to be analyte-specific making them naturally suited for robust chemical sensing. However, current electrochemical microbial biosensors use large and expensive electrochemistry equipment not suitable for on-site, real-time environmental analysis. Here we demonstrate a miniaturized, autonomous bioelectronic sensing system (BESSY) suitable for deployment for instantaneous and continuous sensing applications...
2017: PloS One
https://www.readbyqxmd.com/read/28914190/perioperative-considerations-of-herbal-medications
#7
Ryan M Chadha, Brian J Egan
BACKGROUND: A considerable portion of the US population uses herbal supplements on a daily basis for their various proposed beneficial effects. However, the over-the-counter nature of these medications and lack of knowledge of adverse effect profiles can have unexpected serious impact on the perioperative course. The growing list of supplements presents a pharmacologic conundrum to the anesthesiologist. OBJECTIVE: To compile a comprehensive list of vitamins, herbals, and supplements used commonly by patients, describe the risks associated with them, and identify recommendations for perioperative management...
September 13, 2017: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/28913777/diabetes-and-the-small-intestine
#8
REVIEW
Jonathan Gotfried, Stephen Priest, Ron Schey
Diabetes mellitus (DM) and its associated complications are becoming increasingly prevalent. Gastrointestinal symptoms associated with diabetes is known as diabetic enteropathy (DE) and may manifest as either diarrhea, fecal incontinence, constipation, dyspepsia, nausea, and vomiting or a combination of symptoms. The long-held belief that vagal autonomic neuropathy is the primary cause of DE has recently been challenged by newer theories of disease development. Specifically, hyperglycemia and the resulting oxidative stress on neural networks, including the nitrergic neurons and interstitial cells of Cajal (ICC), are now believed to play a central role in the development of DE...
September 15, 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28912781/microrna-dynamic-regulators-of-macrophage-polarization-and-plasticity
#9
REVIEW
Jezrom Bokcaerin Self-Fordham, Afsar Raza Naqvi, Juhi Raju Uttamani, Varun Kulkarni, Salvador Nares
The ability of a healthy immune system to clear the plethora of antigens it encounters incessantly relies on the enormous plasticity displayed by the comprising cell types. Macrophages (MΦs) are crucial member of the mononuclear phagocyte system (MPS) that constantly patrol the peripheral tissues and are actively recruited to the sites of injury and infection. In tissues, infiltrating monocytes replenish MΦ. Under the guidance of the local micro-milieu, MΦ can be activated to acquire specialized functional phenotypes...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28905399/microdosimetric-measurements-of-a-clinical-proton-beam-with-micrometer-sized-solid-state-detector
#10
Sarah E Anderson, Keith M Furutani, Linh T Tran, Lachlan Chartier, Marco Petasecca, Michael Lerch, Dale A Prokopovich, Mark Reinhard, Vladimir L Perevertaylo, Anatoly B Rosenfeld, Michael G Herman, Chris Beltran
PURPOSE: Microdosimetry is a vital tool for assessing the microscopic patterns of energy deposition by radiation, which ultimately govern biological effect. Solid-state, silicon-on-insulator microdosimeters offer an approach for making microdosimetric measurements with high spatial resolution (on the order of tens of micrometers). These high-resolution, solid-state microdosimeters may therefore play a useful role in characterizing proton radiotherapy fields, particularly for making highly-resolved measurements within the Bragg peak region...
September 14, 2017: Medical Physics
https://www.readbyqxmd.com/read/28904190/exploring-the-human-nipah-virus-protein-protein-interactions
#11
Luis Martinez-Gil, Natalia M Vera-Velasco, Ismael Mingarro
Nipah virus is an emerging, highly pathogenic, zoonotic virus of the paramyxoviridiae family. Human transmission occurs by close contact with infected animals, the consumption of contaminated food, or, occasionally, via other infected individuals. Currently, we lack therapeutic or prophylactic treatments for Nipah virus. To develop these agents we must now improve our understanding of the host-virus interactions that underpin a productive infection. This aim led us to perform the present work, in which we identified (101) human-Nipah virus protein-protein interactions (PPIs), most of which (88) are novel...
September 13, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28902494/fully-atomistic-understanding-of-the-electronic-and-optical-properties-of-a-prototypical-doped-charge-transfer-interface
#12
Anu Baby, Marco Gruenewald, Christian Zwick, Felix Otto, Roman Forker, Gerben van Straaten, Markus Franke, Benjamin Stadtmüller, Christian Kumpf, Gian Paolo Brivio, Guido Fratesi, Torsten Fritz, Egbert Zojer
The current study generates profound atomistic insights into doping-induced changes of the optical and electronic properties of the prototypical PTCDA/Ag(111) interface. For doping K atoms are used, as KxPTCDA/Ag(111) has the distinct advantage of forming well-defined stoichiometric phases. To arrive at a conclusive, unambiguous, and fully atomistic understanding of the interface properties, we combine state-of-the-art density-functional theory calculations with optical differential reflectance data, photoelectron spectra, and x-ray standing wave measurements...
September 13, 2017: ACS Nano
https://www.readbyqxmd.com/read/28899089/highly-active-multimetallic-palladium-nanoalloys-embedded-in-conducting-polymer-as-anode-catalyst-for-electrooxidation-of-ethanol
#13
Srabanti Ghosh, Susmita Bera, Sandip Bysakh, Rajendra Nath Basu
Fabrication of multimetallic nanocatalysts with controllable composition remains a challenge for the development of low-cost electrocatalysts and incorporating metal-based catalysts into active carbon nanoarchitecture represents an emerging strategy to improve the catalytic performance of electrocatalysts. Herein, a facile method developed for Pd nanoparticles (NPs) based multimetallic alloys incorporated on polypyrrole (Ppy) nanofibers by in situ nucleation and growth of NPs using colloidal radiolytic technique...
September 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28898826/identification-of-hotspots-for-no-and-n2o-production-and-consumption-in-counter-and-co-diffusion-biofilms-for-simultaneous-nitrification-and-denitrification
#14
Co Thi Kinh, Shohei Riya, Masaaki Hosomi, Akihiko Terada
A membrane-aerated biofilm reactor (MABR) provides a counter-current substrate diffusion geometry in which oxygen is supplied from a gas-permeable membrane on which a biofilm is grown. This study hypothesized that an MABR would mitigate NO and N2O emissions compared with those from a conventional biofilm reactor (CBR). Two laboratory-scale reactors, representing an MABR and CBR, were operated by feeding synthetic industrial wastewater. The surficial nitrogen removal rate for the MABR [4.51±0.52g-N/(m(2)day)] was higher than that for the CBR [3...
August 12, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28894633/establishment-of-application-guidance-for-otc-non-kampo-crude-drug-extract-products-in-japan
#15
REVIEW
Layla Somekawa, Hikoichiro Maegawa, Shinsuke Tsukada, Takatoshi Nakamura
Currently, there are no standardized regulatory systems for herbal medicinal products worldwide. Communication and sharing of knowledge between different regulatory systems will lead to mutual understanding and might help identify topics which deserve further discussion in the establishment of common standards. Regulatory information on traditional herbal medicinal products in Japan is updated by the establishment of Application Guidance for over-the-counter non-Kampo Crude Drug Extract Products. We would like to report on updated regulatory information on the new Application Guidance...
July 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28894502/use-of-smoking-cessation-products-a-survey-of-patients-in-community-pharmacies
#16
Alan Phung, Lauren Luo, Noor Breik, Silvia Alessi-Severini
OBJECTIVES: At 17.3%, smoking rates in Manitoba continue to exceed the national average. In this province, a total health care spending of more than $200 million per year has been attributed to smoking. This study examined the use of smoking cessation agents, including nicotine replacement products and prescription medications, in a sample of smokers in the city of Winnipeg. METHODS: A simple multiple-choice questionnaire was administered to willing individuals attending 2 community pharmacies in Winnipeg, Manitoba...
September 2017: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
https://www.readbyqxmd.com/read/28892307/purification-of-polysaccharide-from-artificially-cultivated-anoectochilus-roxburghii-wall-lindl-by-high-speed-counter-current-chromatography-and-its-antitumor-activity
#17
Xiaoling Yu, Shouer Lin, Jinque Zhang, Liying Huang, Hong Yao, Shaoguang Li
To establish a systematic method for the extraction, purification, characterization and antitumor activity study of polysaccharide from artificially cultivated Anoectochilus roxburghii(wall.) Lindl. (AC-ARPS). High-speed counter current chromatography with two-phase aqueous systems was successfully applied to purify AC-ARPS after one-step separation. The purity of the AC-ARPS obtained by phenol/sulfuric acid method was 95.01%. The chemical structures of AC-ARPS were identified by a series analytical methods including high-performance liquid chromatography and liquid chromatography with mass spectrometry...
September 11, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28888944/the-novel-dopamine-d3-receptor-antagonists-partial-agonists-cab2-015-and-bak4-54-inhibit-oxycodone-taking-and-oxycodone-seeking-behavior-in-rats
#18
Zhi-Bing You, Jun-Tao Gao, Guo-Hua Bi, Yi He, Comfort Boateng, Jianjing Cao, Eliot L Gardner, Amy Hauck Newman, Zheng-Xiong Xi
The use of prescription opioid analgesics, particularly oxycodone, has dramatically increased, and parallels escalated opioid abuse and drug-related deaths worldwide. Understanding the molecular mechanisms underlying the development of opioid dependence and expanding treatment options to counter prescription opioid abuse has become a critical public health matter. In the present study, we first evaluated the reinforcing effects of oxycodone in a rat model of self-administration and then explored the potential utility of two novel high affinity dopamine D3 receptor (D3R) antagonists/partial agonists, CAB2-015 and BAK4-54, for treatment of prescription opioid abuse and dependence...
September 6, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28888893/face-working-memory-deficits-in-developmental-prosopagnosia-tests-of-encoding-limits-and-updating-processes
#19
Margaret C Jackson, Paul Counter, Jeremy J Tree
Developmental prosopagnosia (DP) is a condition in which individuals experience life-long problems recognising faces. In recent years, unpacking the nature of the impairments of this population has been the focus of numerous studies. One focus has been on the nature of face-based memory impairments for such individuals, with the onus being mainly on long-term memory deficits. Far fewer have considered the nature of face-based working memory (WM) impairments for DP cases, and the current study seeks to address this...
September 6, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28886718/repositioning-drugs-for-traumatic-brain-injury-n-acetyl-cysteine-and-phenserine
#20
REVIEW
Barry J Hoffer, Chaim G Pick, Michael E Hoffer, Robert E Becker, Yung-Hsiao Chiang, Nigel H Greig
Traumatic brain injury (TBI) is one of the most common causes of morbidity and mortality of both young adults of less than 45 years of age and the elderly, and contributes to about 30% of all injury deaths in the United States of America. Whereas there has been a significant improvement in our understanding of the mechanism that underpin the primary and secondary stages of damage associated with a TBI incident, to date however, this knowledge has not translated into the development of effective new pharmacological TBI treatment strategies...
September 9, 2017: Journal of Biomedical Science
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