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https://www.readbyqxmd.com/read/28214069/-pharmacokinetic-drug-interaction-between-miconazole-mucoadhesive-tablet-and-tacrolimus-about-3%C3%A2-case-reports-in-transplant-patients
#1
Marion Lepelley, Sophie Logerot, Xavier Fonrose, Céline Villier
Loramyc(®) is a mucoadhesive tablet of miconazole, indicated for the treatment of oropharyngeal candidiasis in immunocompromised patients. Miconazole, as others azole antifungals, is known for its potent inhibitory properties of cytochromes P450 enzymes and P-glycoprotein (P-gp). Inhibition of cytochromes P450 enzymes and P-gp can produce pharmacokinetic drug interaction. Immunosuppressive agents, such as calcineurin inhibitors (tacrolimus, cyclosporine) are substrates of cytochromes P450 3A4 and P-gp. Nevertheless, the impact of systemic absorption of miconazole mucoadhesive tablet has not been investigated by the laboratory before regulatory approval...
January 12, 2017: Thérapie
https://www.readbyqxmd.com/read/28208243/direct-determination-of-ascorbic-acid-in-a-grapefruit-paving-the-way-for-in-vivo-spectroelectrochemistry
#2
Jesus Garoz-Ruiz, Aranzazu Heras, Alvaro Colina
The study of real samples is more complicated than the study of other systems. However, the inherent advantages of UV-vis absorption spectroelectrochemistry should overcome some difficulties related to direct measurements in complex matrices. For this reason, a singular spectroelectrochemistry device has been fabricated and validated. The novel cell is based on single-walled carbon nanotubes, which are filtered and subsequently press-transferred on a polyethylene terephthalate support using a stencil with a custom design...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28205376/drug-drug-interactions-in-pediatric-oncology-patients
#3
T E Balk, I H van der Sijs, T van Gelder, J J B Janssen, I M van der Sluis, R W F van Leeuwen, F K Engels
BACKGROUND: Drug-drug interactions (DDIs) can negatively affect pharmacotherapy. However, pediatric DDI studies are scarce. We undertook an exploratory study to investigate prevalence and clinical relevance of DDIs between cytostatic and noncytostatic drugs in outpatient pediatric oncology patients. PROCEDURE: After informed consent and inclusion, the following information was collected: currently prescribed noncytostatic and cytostatic drugs, comorbidities, and use of over-the-counter (OTC) drugs, complementary and alternative medicines (CAMs), and dietary supplements...
February 16, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28202320/the-women-s-empower-survey-identifying-women-s-perceptions-on-vulvar-and-vaginal-atrophy-and-its-treatment
#4
Sheryl A Kingsberg, Michael Krychman, Shelli Graham, Brian Bernick, Sebastian Mirkin
INTRODUCTION: Vulvar and vaginal atrophy (VVA) affects up to two thirds of postmenopausal women, but most symptomatic women do not receive prescription therapy. AIM: To evaluate postmenopausal women's perceptions of VVA and treatment options for symptoms in the Women's EMPOWER survey. METHODS: The Rose Research firm conducted an internet survey of female consumers provided by Lightspeed Global Market Insite. Women at least 45 years of age who reported symptoms of VVA and residing in the United States were recruited...
February 12, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28197758/blocking-effects-in-non-conditioned-goal-directed-behaviour
#5
Ann-Kathrin Stock, Krutika Gohil, Christian Beste
A great deal of our goal-directed behaviour depends on stimulus-response (S-R) associations, which can be established through conditioning or explicit instructions. For conditioned and reward maximizing behaviour, it has been shown that redundant information will no longer be taken into account once those associations have been formed ("blocking effect"). Following from this, new aspects will not be included in a pre-established association unless they improve behaviour. Opposing this, influential action control theories state that all kinds of information may be taken into account during action selection, thus denying the possibility of blocking redundant "surplus" information from non-conditioned goal-directed behaviour...
February 14, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28195296/hard-carbon-anodes-of-sodium-ion-batteries-undervalued-rate-capability
#6
Zhifei Li, Zelang Jian, Xingfeng Wang, Ismael A Rodríguez-Pérez, Clement Bommier, Xiulei Ji
The rate capability of hard carbon has long been underestimated in prior studies that used carbon/Na two-electrode half-cells. Through a three-electrode cell setup, we discover that it is the overpotential of the sodium counter electrode that drives the half-cells to the lower cutoff potential prematurely during hard carbon sodiation, particularly at high current rates, which prevents the hard carbon anode from being fully sodiated.
February 14, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28194613/is-the-surface-potential-integral-of-a-dipole-in-a-volume-conductor-always-zero-a-cloud-over-the-average-reference-of-eeg-and-erp
#7
Dezhong Yao
Currently, average reference is one of the most widely adopted references in EEG and ERP studies. The theoretical assumption is the surface potential integral of a volume conductor being zero, thus the average of scalp potential recordings might be an approximation of the theoretically desired zero reference. However, such a zero integral assumption has been proved only for a spherical surface. In this short communication, three counter-examples are given to show that the potential integral over the surface of a dipole in a volume conductor may not be zero...
February 14, 2017: Brain Topography
https://www.readbyqxmd.com/read/28193063/electrochemical-impedance-spectroscopy-in-a-droplet-of-solution-for-the-investigation-of-liquid-solid-interface
#8
Camila Molena de Assis, Thu Huong Ho, Hercilio Gomes de Melo, Michel Keddam, Mireille Turmine, Vincent Vivier
The local electrochemical behavior of a solid-liquid interface can be studied by electrochemical impedance spectroscopy (EIS). The investigated surface area can be delimited by adding a drop of solution, which forms an interface between the liquid drop and the working electrode, and performing the measurements inside. The size of the drop must be sufficiently small for a simultaneous wettability characterization (from the contact angle measurement) and appropriately large so that wettability is not influenced by the presence of the working and the counter electrode inserted in the droplet...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28190594/separation-of-betacyanins-from-purple-flowers-of-gomphrena-globosa-l-by-ion-pair-high-speed-counter-current-chromatography
#9
Aneta Spórna-Kucab, Joanna Jagodzińska, Sławomir Wybraniec
Betacyanins, known as antioxidants and chemopreventive natural compounds with colourful properties, were extracted from purple flowers of Gomphrena globosa L. belonging to the Amaranthaceae family and separated for the first time by ion-pair high-speed counter-current chromatography (HSCCC). The pigments were detected by LC-DAD-ESI-MS/MS technique. Separation of betacyanins (300mg) by HSCCC was accomplished in four solvent systems: tert-butyl methyl ether - butanol - acetonitrile - water (0.7% and 1.0% HFBA - heptafluorobutyric acid - system I and III) and tert-butyl methyl ether - butanol - methanol - water (0...
January 25, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28185147/incompatible-with-care-examining-trisomy-18-medical-discourse-and-families-counter-discourse-for-recuperative-ethos
#10
Megan J Thorvilson, Adam J Copeland
Parents whose child is diagnosed with a serious disease such as trisomy 18 first rely on the medical community for an accurate description and prognosis. In the case of trisomy 18, however, many families are told the disease is "incompatible with life" even though some children with the condition live for several years. This paper considers parents' response to current medical discourse concerning trisomy 18 by examining blogs written by the parents of those diagnosed. Using interpretive humanistic reading and foregrounding Cathryn Molloy's recuperative ethos theory (2015), we find that parents demonstrate recuperative ethos in response to physicians' descriptions of trisomy 18, particularly in rhetoric addressing survival, medicalized language, and religious and/or spiritual rhetoric...
February 10, 2017: Journal of Medical Humanities
https://www.readbyqxmd.com/read/28182172/chronic-disease-self-management-support-for-persons-with-dementia-in-a-clinical-setting
#11
Joseph Elias Ibrahim, Laura J Anderson, Aleece MacPhail, Janaka Jonathan Lovell, Marie-Claire Davis, Margaret Winbolt
The burden of chronic disease is greater in individuals with dementia, a patient group that is growing as the population is aging. The cornerstone of optimal management of chronic disease requires effective patient self-management. However, this is particularly challenging in older persons with a comorbid diagnosis of dementia. The impact of dementia on a person's ability to self-manage his/her chronic disease (eg, diabetes mellitus or heart failure) varies according to the cognitive domain(s) affected, severity of impairment and complexity of self-care tasks...
2017: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/28179412/sharpening-host-defenses-during-infection-proteases-cut-to-the-chase
#12
Natalie C Marshall, B Brett Finlay, Christopher M Overall
The human immune system consists of an intricate network of tightly controlled pathways, where proteases are essential regulators and executioners at multiple levels. Invading microbial pathogens also encode proteases that have evolved to manipulate and dysregulate host proteins including host proteases during the course of disease. The identification of pathogen proteases as well as their substrates and mechanisms of action have empowered significant developments in therapeutics for infectious diseases. Yet for many pathogens, there remains a great deal to be discovered...
February 8, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28179003/respiratory-outcomes-of-ultrafine-particulate-matter-ufpm-as-a-surrogate-measure-of-near-roadway-exposures-among-bicyclists
#13
Hye-Youn Park, Susan Gilbreath, Edward Barakatt
BACKGROUND: Studies have shown a consistent association between exposure to traffic-related air pollution and adverse health effects. In particular, exposure can be high for cyclists who travel near roadways. The objective of the current study was to examine the relationship between short-term exposure of near-road traffic emissions and acute changes in lung function among individuals who frequently bike in the Sacramento and Davis areas in California. Ultrafine particulate matter (UFPM) was used as a surrogate for near-roadway exposure in this study since the main source of this pollutant is from motor vehicle exhaust...
February 8, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28178741/-the-importance-of-hospital-hygiene-findings-of-a-german-nationwide-survey
#14
Dennis Haking
The German legislature reacted to the increasing number of nosocomial infections with a set of laws to strengthen hospital hygiene. The aim of the study is to measure the current and future importance of hospital hygiene in Germany. CEOs and hygiene staff from German hospitals took part in a survey on 13 items regarding the current and future importance of hospital hygiene. Statistical analyses were conducted to identify significances regarding the professional groups. The results of the study show that hospital hygiene is currently of high importance and will be rising in the future...
February 8, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28173821/identification-of-influenza-a-nucleoprotein-body-domain-residues-essential-for-viral-rna-expression-expose-antiviral-target
#15
Alicia M Davis, Jose Ramirez, Laura L Newcomb
BACKGROUND: Influenza A virus is controlled with yearly vaccination while emerging global pandemics are kept at bay with antiviral medications. Unfortunately, influenza A viruses have emerged resistance to approved influenza antivirals. Accordingly, there is an urgent need for novel antivirals to combat emerging influenza A viruses resistant to current treatments. Conserved viral proteins are ideal targets because conserved protein domains are present in most, if not all, influenza subtypes, and are presumed less prone to evolve viable resistant versions...
February 7, 2017: Virology Journal
https://www.readbyqxmd.com/read/28168837/immunity-in-filarial-infections-lessons-from-animal-models-and-human-studies
#16
REVIEW
Alexander Kwarteng, Samuel Terkper Ahuno
Our understanding of immunity to filarial infection is enigmatic and continues to be passionately debated. The mechanisms whereby filarial nematodes are killed in vivo and how these parasites avoid these mechanisms are poorly understood. Although vaccination studies in permissive animals took off seven decades ago, the exact mechanisms driving protective immunity is extensively being investigated. Currently, little is known regarding the collective functions or counter-regulatory mechanisms of the antibody isotypes in filarial infection with respect to protective immunity...
February 7, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28166948/heat-transfer-analysis-of-skin-during-thermal-therapy-using-thermal-wave-equation
#17
Meisam Kashcooli, Mohammad Reza Salimpour, Ebrahim Shirani
Specifying exact geometry of vessel network and its effect on temperature distribution in living tissues is one of the most complicated problems of the bioheat field. In this paper, the effects of blood vessels on temperature distribution in a skin tissue subjected to various thermal therapy conditions are investigated. Present model consists of counter-current multilevel vessel network embedded in a three-dimensional triple-layered skin structure. Branching angles of vessels are calculated using the physiological principle of minimum work...
February 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28164437/separation-of-six-xanthones-from-swertia-franchetiana-by-high-speed-counter-current-chromatography
#18
Hongmei Li, Tao Chen, Jing Sun, Weiqing Wang, Yulin Li
Two groups of xanthone isomers (1-hydroxy-3,5,8-trimethoxyxanthone and 1-hydroxy-3,7,8-trimethoxyxanthone, 1,8-dihydroxy-3,7-dimethoxyxanthone and 1,8-dihydroxy-3,5-dimethanolxanthone) and two other xanthones (3-methoxy-1,5,8-trihydroxyxanthone and 3,5-dimethoxy-1-hydroxyxanthone) were separated from Swertia franchetiana. First, a solvent system composed of petroleum ether/methanol/water (2:1:0.6, v/v) was developed for the liquid-liquid extraction of these xanthones from the crude extract. Then, an efficient method was established for one step separation of these six xanthones by high-speed counter-current chromatography using n-hexane/ethyl acetate/methanol/ethanol/water (6:4:4:2:4, v/v) as the solvent system...
February 6, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28164426/mechanisms-of-charge-transfer-in-human-copper-atpases-atp7a-and-atp7b
#19
REVIEW
Francesco Tadini-Buoninsegni, Serena Smeazzetto
ATP7A and ATP7B are Cu(+) -transporting ATPases of subclass IB and play a fundamental role in intracellular copper homeostasis. ATP7A/B transfer Cu(+) ions across the membrane from delivery to acceptor proteins without establishing a free Cu(+) gradient. Transfer of copper across the membrane is coupled to ATP hydrolysis. Current measurements on solid supported membranes (SSM) were performed to investigate the mechanism of copper-related charge transfer across ATP7A and ATP7B. SSM measurements demonstrated that electrogenic copper displacement occurs within ATP7A/B following addition of ATP and formation of the phosphorylated intermediate...
February 5, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28163027/pharmacists-readiness-to-provide-naloxone-in-community-pharmacies-in-west-virginia
#20
J Douglas Thornton, Elizabeth Lyvers, Virginia Ginger G Scott, Nilanjana Dwibedi
OBJECTIVES: The objective of this study is to assess West Virginia pharmacists' stocking and dispensing practices of opioid-related medications and to identify the educational needs relating to providing naloxone in community pharmacies. DESIGN: A cross-sectional, anonymous, 49-item survey was created and validated to assess the educational needs of West Virginia community pharmacists. SETTING: West Virginia. PARTICIPANTS: The data collection instrument was administered to 266 pharmacists currently licensed in West Virginia at 6 continuing pharmacy education events throughout the state from March 1 to June 15, 2016...
February 2, 2017: Journal of the American Pharmacists Association: JAPhA
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