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https://www.readbyqxmd.com/read/29786682/-the-implementation-of-the-method-of-enhanced-external-counter-pulsation-for-the-treatment-of-cardiovascular-diseases
#1
V A Badtieva, D N Voroshilova
The cardiovascular diseases occupy a leading place in the structure of overall morbidity affecting the population not only of Russia but also of the majority of the developed countries throughout the world; they thus impose the heavy social and economic burden on both the public healthcare services and the modern society in general. At the same time, systemic atherosclerosis is considered to be one of the most common, severe, and life-threatening condition. Despite the presence of a large number of pharmaceutical and surgical methods for the treatment of this pathology, they are not infrequently lacking the desired effectiveness...
May 21, 2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29785004/a-direct-tissue-grafting-approach-to-increasing-endogenous-brown-fat
#2
Nicole R Blumenfeld, Hwan June Kang, Anna Fenzl, Ziwei Song, Janice J Chung, Ranjodh Singh, Roshawn Johnson, Ayse Karakecili, Jun B Feranil, Ninna S Rossen, Vivian Zhang, Sahir Jaggi, Bret McCarty, Steven Bessler, Gary J Schwartz, Robert Grant, Judith Korner, Florian W Kiefer, Brian M Gillette, Samuel K Sia
There is widespread evidence that increasing functional mass of brown adipose tissue (BAT) via browning of white adipose tissue (WAT) could potentially counter obesity and diabetes. However, most current approaches focus on administration of pharmacological compounds which expose patients to highly undesirable side effects. Here, we describe a simple and direct tissue-grafting approach to increase BAT mass through ex vivo browning of subcutaneous WAT, followed by re-implantation into the host; this cell-therapy approach could potentially act synergistically with existing pharmacological approaches...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29778718/nimbolide-epigenetically-regulates-autophagy-and-apoptosis-in-breast-cancer
#3
Venkatesh Pooladanda, Soumya Bandi, Sandhya Rani Mondi, Krishna Mohan Gottumukkala, Chandraiah Godugu
Autophagy is a critical regulator of cellular homeostasis and its dysregulation often results in various disease manifestations, including cancer. Nimbolide, an active chemical constituent of neem (Azadirachta indica) exhibits potent anticancer effects. Although, nimbolide mediated apoptosis activation in breast cancer cells is well known. Nevertheless, its role in autophagy induction mechanism and epigenetic alteration is not explored previously. Our current study intended to bridge the gaps in the existing research by exploring the potential of nimbolide in inducing autophagy, which could counter regulate the transformations in breast cancer...
May 17, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29778020/eosin-y-sensitized-core-shell-tio-2-zno-nano-structured-photoanodes-for-dye-sensitized-solar-cell-applications
#4
V S Manikandan, Akshaya K Palai, Smita Mohanty, Sanjay K Nayak
In the current investigation, TiO2 and TiO2 -ZnO (core-shell) spherical nanoparticles were synthesized by simple combined hydrolysis and refluxing method. A TiO2 core nanomaterial on the shell material of ZnO was synthesized by utilizing variable ratios of ZnO. The structural characterization of TiO2 -ZnO core/shell nanoparticles were done by XRD analysis. The spherical structured morphology of the TiO2 -ZnO has been confirmed through field emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM) studies...
May 3, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29777174/how-does-blood-regulate-cerebral-temperatures-during-hypothermia
#5
Stephen Blowers, Ian Marshall, Michael Thrippleton, Peter Andrews, Bridget Harris, Iain Bethune, Prashant Valluri
Macro-modeling of cerebral blood flow can help determine the impact of thermal intervention during instances of head trauma to mitigate tissue damage. This work presents a bioheat model using a 3D fluid-porous domain coupled with intersecting 1D arterial and venous vessel trees. This combined vascular porous (VaPor) model resolves both cerebral blood flow and energy equations, including heat generated by metabolism, using vasculature extracted from MRI data and is extended using a tree generation algorithm...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29771292/separation-of-four-flavonol-glycosides-from-solanum-rostratum-dunal-using-solvent-sublation-followed-by-hsccc-and-low-column-temperature-preparative-hplc
#6
Qian Shao, Lin Chang, Zhenya Wei, Yun Wei
Hyperoside, 3'-O-methylquercetin 3-O-β-D-galactopyranoside, astragalin and 3'-O-methylquercetin 3-O-β-D-glucopyranoside from an invasive weed Solanum rostratum Dunal were separated and purified successfully by high-speed counter-current chromatography (HSCCC) with a solvent system composed of n-hexane-ethyl acetate-methanol-water (1:7:1:7, v/v) and gradient elution mode preparative high-performance liquid chromatography (prep-HPLC) with low column temperature. In the sample pretreatment section, target compounds in aqueous extract of the weed were concentrated using solvent sublation...
May 16, 2018: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/29763399/can-congress-get-right-to-try-right
#7
Richard Mark Kirkner
A federal bill would expand access to experimental treatments to seriously ill patients, but critics say the right to try would take away FDA oversight and create a "Wild West." Proponents counter that the FDA's current process can be onerous for people with just a few months to live. Meanwhile, most states' right-to-try laws have gone unused.
May 2018: Managed Care
https://www.readbyqxmd.com/read/29762469/individualised-multimodal-treatment-strategies-for-anaplastic-and-poorly-differentiated-thyroid-cancer
#8
Sabine Wächter, Annette Wunderlich, Silvia Roth, Ioannis Mintziras, Elisabeth Maurer, Sebastian Hoffmann, Frederik A Verburg, Sebastian A Fellinger, Katharina Holzer, Detlef K Bartsch, Pietro Di Fazio
The prognosis of anaplastic (ATC) and poorly differentiated thyroid cancer (PDTC) is poor, due to their radioiodine refractoriness (RAI-R), high metastatic potential and current lack of effective treatment strategies. We aimed to examine the efficacy of the tyrosine kinase inhibitors (TKIs) sorafenib and selumetinib and the histone deacetylase inhibitor (HDACI) panobinostat in patient-derived tumor tissue (PDTT) of ATCs/PDTCs, the expression of sodium iodide symporter ( NIS ) and radioiodine up-take (RAI-U)...
May 15, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29757020/recent-advances-in-the-treatment-of-brugada-syndrome
#9
Mariana Argenziano, Charles Antzelevitch
Brugada syndrome (BrS) is an inherited cardiac arrhythmia syndrome characterized by ST-segment elevation in right precordial ECG leads and associated with sudden cardiac death in young adults. The ECG manifestations of BrS are often concealed but can be unmasked by sodium channel blockers and fever. Areas covered: Implantation of a cardioverter defibrillator (ICD) is first-line therapy for BrS patients presenting with prior cardiac arrest or documented VT. A pharmacological approach to therapy is recommended in cases of electrical storm, as an adjunct to ICD and as preventative therapy...
May 14, 2018: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29751487/preparation-and-antioxidant-activity-of-ethyl-linked-anthocyanin-flavanol-pigments-from-model-wine-solutions
#10
Lingxi Li, Minna Zhang, Shuting Zhang, Yan Cui, Baoshan Sun
Anthocyanin-flavanol pigments, formed during red wine fermentation and storage by condensation reactions between anthocyanins and flavanols (monomers, oligomers, and polymers), are one of the major groups of polyphenols in aged red wine. However, knowledge of their biological activities is lacking. This is probably due to the structural diversity and complexity of these molecules, which makes the large-scale separation and isolation of the individual compounds very difficult, thus restricting their further study...
May 3, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29749294/questioning-the-current-public-health-approach-to-countering-violent-extremism
#11
Neil Krishan Aggarwal
Since the start of the global War on Terror, governments have used the mental health system for counterintelligence purposes. A recent manifestation of this trend is the call from policymakers and mental health researchers to screen individuals at risk for violent extremism through the public health system. Civil rights organisations have raised alarms that Muslims are being disproportionately referred to law enforcement agencies and that Muslim communities are being selected for surveillance despite government assurances that violent extremism is not exclusive to any ideology...
May 11, 2018: Global Public Health
https://www.readbyqxmd.com/read/29748985/preparative-isolation-of-ganoderic-acid-s-ganoderic-acid-t-and-ganoderol-b-from-ganoderma-lucidum-mycelia-by-high-speed-counter-current-chromatography
#12
Na Feng, Yutian Wei, Jie Feng, Qingjiu Tang, Zhong Zhang, Jingsong Zhang, Han Wei
Ganoderic acid S, ganoderic acid T, and ganoderal B are the main bioactive triterpenes of Ganoderma lucidum. In this study, mycelia of Ganoderma lucidum were obtained by two-stage fermentation and then extracted by ethanol and petroleum ether sequentially to obtain crude triterpenes. The crude sample was further purified by recycling high-speed counter-current chromatography (HSCCC) with n-hexane: ethyl acetate: methanol: water (7:12:11:5, v/v/v/v) as the optimized two-phase solventsystem. 16.4 mg of ganoderol B with the purity of 90...
May 10, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29747078/mechanisms-of-acetylcholinesterase-protection-against-sarin-and-soman-by-adenosine-a-1-receptor-agonist-n-6-cyclopentyladenosine
#13
Ariana Beste, DeCarlos E Taylor, Tsung-Ming Shih, Thaddeus P Thomas
Organophosphorus nerve agents (NAs) irreversibly inhibit acetylcholinesterase (AChE), the enzyme responsible for breaking down the neurotransmitter acetylcholine (ACh). The over accumulation of ACh after NA exposure leads to cholinergic toxicity, seizure, and death. Current medical countermeasures effectively mitigate peripheral symptoms, however; the brain is often unprotected. Alternative acute treatment with the adenosine A1 receptor agonist N6 -cyclopentyladensosine (CPA) has previously been demonstrated to prevent AChE inhibition as well as to suppress neuronal activity...
May 7, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29738963/purification-of-r-phycoerythrin-from-gracilaria-lemaneiformis-by-centrifugal-precipitation-chromatography
#14
Dongyu Gu, Rodrigo Lazo-Portugal, Chen Fang, Zhantong Wang, Ying Ma, Martha Knight, Yoichiro Ito
Centrifugal precipitation chromatography (CpC) is a powerful chromatographic technique invented in the year 2000 but so far very little applied. The method combines dialysis, counter-current and salting out processes. The separation rotor consists of two identical spiral channels separated by a dialysis membrane (6-8 K MW cut-off) in which the upper channel is eluted with an ammonium sulfate gradient and the lower channel with water, and the mixtures are separated according to their solubility in ammonium sulfate as a chromatographic technique...
May 1, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29734052/critical-analysis-of-forensic-cut-offs-and-legal-thresholds-a-coherent-approach-to-inference-and-decision
#15
A Biedermann, F Taroni, S Bozza, M Augsburger, C G G Aitken
In this paper we critically discuss the definition and use of cut-off values by forensic scientists, for example in forensic toxicology, and point out when and why such values - and ensuing categorical conclusions - are inappropriate concepts for helping recipients of expert information with their questions of interest. Broadly speaking, a cut-off is a particular value of results of analyses of a target substance (e.g., a toxic substance or one of its metabolites in biological sample from a person of interest), defined in a way such as to enable scientists to suggest conclusions regarding the condition of the person of interest...
April 25, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29730748/the-safety-assessment-of-toxic-metals-in-commonly-used-pharmaceutical-herbal-products-and-traditional-herbs-for-infants-in-jordanian-market
#16
Ala A Alhusban, Samah A Ata, Sawsan A Shraim
The objective of this study was to assess the levels of contamination by toxic metals (Pb, Al, Ni, Cd and As) that may be present in 25 infant pharmaceutical herbal products and 15 traditional herbs in Jordan. Both products and medicinal herbs are currently prescribed by paediatricians. They are available as over-the-counter medicines and are sold the in herbal market, ensuring easy accessibility for parents. Inductively coupled plasma-optical emission spectroscopy (ICP-OES), with limit of detections (LODs) of 0...
May 5, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29728537/effect-of-over-the-counter-whitening-products-associated-or-not-with-10-carbamide-peroxide-on-color-change-and-microhardness-in-vitro-study
#17
Ana Lb Jurema, Evaniele S Claudino, Carlos Rg Torres, Eduardo Bresciani, Taciana Mf Caneppele
Aim: The purpose of this in vitro study was to evaluate the color and microhardness of teeth subjected to different over-the-counter (OTC) whitening products in association or not with 10% carbamide peroxide (10% CP). Materials and methods: Enamel-dentin specimens (n = 210) were obtained from bovine incisors and stained. Half of the specimens were then subjected to daily cycles of staining (5 minutes), 10% CP bleaching (8 hours) in association with OTC products, and artificial saliva storage until complete 24 hours, for 2 weeks; the other half was subjected to daily cycles of staining, OTC treatment, and storage in artificial saliva for 12 weeks...
April 1, 2018: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29720924/citropin-1-1-trifluoroacetate-to-chloride-counter-ion-exchange-in-hcl-saturated-organic-solutions-an-alternative-approach
#18
Karol Sikora, Damian Neubauer, Maciej Jaśkiewicz, Wojciech Kamysz
In view of the increasing interest in peptides in various market sectors, a stronger emphasis on topics related to their production has been seen. Fmoc-based solid phase peptide synthesis, although being fast and efficient, provides final products with significant amounts of trifluoroacetate ions in the form of either a counter-ion or an unbound impurity. Because of the proven toxicity towards cells and peptide activity inhibition, ion exchange to more biocompatible one is purposeful. Additionally, as most of the currently used counter-ion exchange techniques are time-consuming and burdened by peptide yield reduction risk, development of a new approach is still a sensible solution...
2018: International Journal of Peptide Research and Therapeutics
https://www.readbyqxmd.com/read/29718590/-one-for-all-strategy-in-fast-energy-storage-production-of-pillared-mof-nanorod-templated-positive-negative-electrodes-for-the-application-of-high-performance-hybrid-supercapacitor
#19
Chong Qu, Zibin Liang, Yang Jiao, Bote Zhao, Bingjun Zhu, Dai Dang, Shuge Dai, Yu Chen, Ruqiang Zou, Meilin Liu
Currently, metal-organic frameworks (MOFs) are intensively studied as active materials for electrochemical energy storage applications due to their tunable structure and exceptional porosities. Among them, water stable pillared MOFs with dual ligands have been reported to exhibit high supercapacitor (SC) performance. Herein, the "One-for-All" strategy is applied to synthesize both positive and negative electrodes of a hybrid SC (HSC) from a single pillared MOF. Specifically, Ni-DMOF-TM ([Ni(TMBDC)(DABCO)0...
May 2, 2018: Small
https://www.readbyqxmd.com/read/29714598/comparison-of-brief-summary-formats-through-a-health-literacy-lens
#20
Michele L Sharp, Lori Hall, Anthony Eleftherion, Katherine Simpson, Linda Neuhauser
BACKGROUND: Print pharmaceutical advertisements in the United States require inclusion of a brief summary of side effects, warnings, precautions, and contraindications from the labeling. The full package insert, which sponsors have traditionally used to fulfill the brief summary requirement, does not adhere to health literacy best practices, limiting its value to consumers. This study compared the understandability and usability of brief summaries in 3 formats designed to be more consumer friendly...
January 1, 2018: Therapeutic Innovation & Regulatory Science
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