Li Zhang, Shichen Xu, Xian Cheng, Jiangxia Zheng, Yunping Wang, Jing Wu, Xiaowen Wang, Liying Wu, Huixin Yu, Jiandong Bao
It is widely accepted that anaplastic thyroid carcinoma (ATC), a rare, extremely aggressive malignant, is enriched by cancer stem cells (CSCs), which are closely related to the pathogenesis of ATC. In the present study, we demonstrated that diallyl trisulphide (DATS), a well-known hydrogen sulphide (H2 S) donor, suppressed sphere formation and restored the expression of iodide-metabolizing genes in human ATC cells, which were associated with H2 S generation. Two other H2 S donors, NaHS and GYY4137, could also suppress the self-renewal properties of ATC cells in vitro...
March 9, 2021: Phytotherapy Research: PTR