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Hydrogen sulphide donors

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https://www.readbyqxmd.com/read/28631296/hydrogen-sulphide-as-a-signaling-molecule-regulating-physiopathological-processes-in-gastrointestinal-motility
#1
REVIEW
M Jimenez, V Gil, M Martinez-Cutillas, N Mañé, D Gallego
The biology of H2 S is an emerging area of research since several biological functions have been recently attributed to this gaseous molecule in a vast number of regions including the cardiovascular, urogenital, respiratory, digestive and central nervous system. H2 S exerts anti-inflammatory effects and can be considered an endogenous mediator with potential effects on gastrointestinal motility. During the last years, our research group has investigated the role of H2 S as a regulator of gastrointestinal motility using both animal and human tissues...
June 20, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28608965/hydrogen-sulphide-modulating-mitochondrial-morphology-to-promote-mitophagy-in-endothelial-cells-under-high-glucose-and-high-palmitate
#2
Ning Liu, Jichao Wu, Linxue Zhang, Zhaopeng Gao, Yu Sun, Miao Yu, Yajun Zhao, Shiyun Dong, Fanghao Lu, Weihua Zhang
Endothelial cell dysfunction is one of the main reasons for type II diabetes vascular complications. Hydrogen sulphide (H2 S) has antioxidative effect, but its regulation on mitochondrial dynamics and mitophagy in aortic endothelial cells under hyperglycaemia and hyperlipidaemia is unclear. Rat aortic endothelial cells (RAECs) were treated with 40 mM glucose and 200 μM palmitate to imitate endothelium under hyperglycaemia and hyperlipidaemia, and 100 μM NaHS was used as an exogenous H2 S donor. Firstly, we demonstrated that high glucose and palmitate decreased H2 S production and CSE expression in RAECs...
June 13, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28512525/h2s-donor-nahs-changes-the-production-of-endogenous-h2s-and-no-in-d-galactose-induced-accelerated-ageing
#3
Wei Wu, Cui-Lan Hou, Xue-Pan Mu, Chen Sun, Yi-Chun Zhu, Ming-Jie Wang, Qian-Zhou Lv
Aims. The study was designed to explore whether hydrogen sulphide (H2S) and nitric oxide (NO) generation changed in D-galactose- (D-gal-) induced ageing, the possible effects of exogenous H2S supplementation, and related mechanisms. Results. In D-gal-induced senescent mice, both H2S and NO levels in the heart, liver, and kidney tissues were decreased significantly. A similar trend was observed in D-gal-challenged human umbilical vein endothelial cells (HUVECs). Sustained H2S donor (NaHS) treatment for 2 months elevated H2S and NO levels in these mice, and during this period, the D-gal-induced senescent phenotype was reversed...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28467198/chronic-nahs-treatment-decreases-oxidative-stress-and-improves-endothelial-function-in-diabetic-mice
#4
Hooi H Ng, Gunes S Yildiz, Jacqueline M Ku, Alyson A Miller, Owen L Woodman, Joanne L Hart
Hydrogen sulphide (H2S) is endogenously produced in vascular tissue and has anti-oxidant and vasoprotective properties. This study investigates whether chronic treatment using the fast H2S donor NaHS could elicit a vasoprotective effect in diabetes. Diabetes was induced in male C57BL6/J mice with streptozotocin (60 mg/kg daily, ip for 2 weeks) and confirmed by elevated blood glucose and glycated haemoglobin levels. Diabetic mice were then treated with NaHS (100 µmol/kg/day) for 4 weeks, and aortae collected for functional and biochemical analyses...
May 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28423592/protective-effect-of-hydrogen-sulphide-against-myocardial-hypertrophy-in-mice
#5
Mingjing Shao, Chuanjun Zhuo, Ronghuan Jiang, Guangdong Chen, Jianmin Shan, Jing Ping, Hongjun Tian, Lina Wang, Chongguang Lin, Lirong Hu
Cardiac hypertrophy is a critical component of phenotype in the failing heart. Recently, increasing evidence has demonstrated that oxidative stress plays an important role in the pathogenesis of myocardial hypertrophy. In the present study, we generated a mouse model of transverse aortic constriction (TAC) to investigate whether hydrogen sulfide (H2S) has protective effects against cardiac hypertrophy. Left ventricular structure was analyzed by two-dimensional echocardiography. Oxidative stress was evaluated by measuring malondialdehyde, superoxide dismutase, glutathione peroxidase and reactive oxygen specie in the myocardium...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28387464/a-novel-ph-controlled-hydrogen-sulfide-donor-protects-gastric-mucosa-from-aspirin-induced-injury
#6
Chun-Tao Yang, Zhen-Zhen Lai, Ze-Hang Zheng, Jian-Ming Kang, Ming Xian, Rui-Yu Wang, Kun Shi, Fu-Hui Meng, Xiang Li, Li Chen, Hui Zhang
Hydrogen sulphide (H2 S) serves as a vital gastric mucosal defence under acid condition. Non-steroidal anti-inflammatory drugs (NSAIDs) are among widely prescribed medications with effects of antipyresis, analgesia and anti-inflammation. However, their inappropriate use causes gastric lesions and endogenous H2 S deficiency. In this work, we reported the roles of a novel pH-controlled H2 S donor (JK-1) in NSAID-related gastric lesions. We found that JK-1 could release H2 S under mild acidic pH and increase solution pH value...
April 7, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28366002/side-by-side-comparison-of-hydroperoxide-and-corresponding-alcohol-as-hydrogen-bond-donors
#7
Kristian H Møller, Camilla Mia Tram, Henrik G Kjaergaard
Hydroperoxides are formed in significant amounts in the atmosphere by oxidation of volatile organic compounds and are key in aerosol formation. In a room-temperature experiment, we detected the formation of bimolecular complexes of tert-butyl hydroperoxide (t-BuOOH) and the corresponding alcohol tert-butanol (t-BuOH), with dimethyl ether (DME) as the hydrogen-bond acceptor. Using a combination of Fourier-transform infrared spectroscopy and quantum chemical calculations, we compare the strength of the OH-O hydrogen bond and the total strength of complexation...
April 20, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27779471/the-adaptive-role-of-nitric-oxide-and-hydrogen-sulphide-in-vasoactive-responses-of-thoracic-aorta-is-triggered-already-in-young-spontaneously-hypertensive-rats
#8
S Cacanyiova, A Berenyiova, F Kristek, M Drobna, K Ondrias, M Grman
The aorta plays an important role in blood pressure control so the early determination of its vasoactive properties could predict pathological changes in hypertension. The aim of study was to compare vasoactive properties and geometry of thoracic aorta (TA) and the participation of two vasoactive transmitters, nitric oxide (NO) and hydrogen sulphide (H2S), in TA tone regulation in young Wistar rats (WR) and spontaneously hypertensive rats (SHR). Four-weeks-old WR and SHR were used. Systolic blood pressure (sBP) was measured by plethysmography...
August 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/27775418/cardiovascular-effects-of-gasotransmitter-donors
#9
REVIEW
M Cebová, M Košútová, O Pecháňová
Gasotransmitters represent a subfamily of the endogenous gaseous signaling molecules that include nitric oxide (NO), carbon monoxide (CO), and hydrogen sulphide (H(2)S). These particular gases share many common features in their production and function, but they fulfill their physiological tasks in unique ways that differ from those of classical signaling molecules found in tissues and organs. These gasotransmitters may antagonize or potentiate each other's cellular effects at the level of their production, their downstream molecular targets and their direct interactions...
October 24, 2016: Physiological Research
https://www.readbyqxmd.com/read/27616550/the-novel-h2s-donor-4-carboxyphenyl-isothiocyanate-promotes-cardioprotective-effects-against-ischemia-reperfusion-injury-through-activation-of-mitokatp-channels-and-reduction-of-oxidative-stress
#10
Lara Testai, Alice Marino, Ilaria Piano, Vincenzo Brancaleone, Kengo Tomita, Lorenzo Di Cesare Mannelli, Alma Martelli, Valentina Citi, Maria C Breschi, Roberto Levi, Claudia Gargini, Mariarosaria Bucci, Giuseppe Cirino, Carla Ghelardini, Vincenzo Calderone
The endogenous gasotransmitter hydrogen sulphide (H2S) is an important regulator of the cardiovascular system, particularly of myocardial function. Moreover, H2S exhibits cardioprotective activity against ischemia/reperfusion (I/R) or hypoxic injury, and is considered an important mediator of "ischemic preconditioning", through activation of mitochondrial potassium channels, reduction of oxidative stress, activation of the endogenous "anti-oxidant machinery" and limitation of inflammatory responses. Accordingly, H2S-donors, i...
September 9, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27057284/the-h2s-donor-nahs-changes-the-expression-pattern-of-h2s-producing-enzymes-after-myocardial-infarction
#11
Na Li, Ming-Jie Wang, Sheng Jin, Ya-Dan Bai, Cui-Lan Hou, Fen-Fen Ma, Xing-Hui Li, Yi-Chun Zhu
Aims. To examine the expression patterns of hydrogen sulphide- (H2S-) producing enzymes in ischaemic heart tissue and plasma levels of H2S after 2 weeks of NaHS treatment after myocardial infarction (MI) and to clarify the role of endogenous H2S in the MI process. Results. After MI surgery, 2 weeks of treatment with the H2S donor NaHS alleviated ischaemic injury. Meanwhile, in ischemia myocardium, three H2S-producing enzymes, cystathionine γ-lyase (CSE), cystathionine-β-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (3-MST) significantly increased...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/26968978/exogenous-hydrogen-sulphide-ameliorates-diabetic-cardiomyopathy-in-rats-by-reversing-disordered-calcium-handling-system-in-sarcoplasmic-reticulum
#12
Yu-Si Cheng, De-Zai Dai, Yin Dai, Dong-Dong Zhu, Bi-Cheng Liu
OBJECTIVES: Hydrogen sulphide (H2 S) has been found to be involved in cardiovascular diseases, but the exact mechanism has not been clarified. The purpose of this study was to investigate whether sodium hydrogen sulphide (NaHS), the donor of H2 S, can improve diabetic cardiomyopathy by reversing disordered calcium-handling system in sarcoplasmic reticulum (SR). METHODS: Sprague Dawley rats were injected with streptozotocin (STZ, 60 mg/kg, i.p.) to build diabetic model...
March 2016: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/26963622/up-regulation-of-cystathione-%C3%AE-lyase-and-hydrogen-sulphide-in-the-myocardium-inhibits-the-progression-of-isoproterenol-caffeine-induced-left-ventricular-hypertrophy-in-wistar-kyoto-rats
#13
Ashfaq Ahmad, Munavvar A Sattar, Hassaan A Rathore, Mohammed H Abdulla, Safia A Khan, Maleeha Azam, Nor A Abdullah, Edward J Johns
Hydrogen sulphide (H2S) is an emerging molecule in many cardiovascular complications but its role in left ventricular hypertrophy (LVH) is unknown. The present study explored the effect of exogenous H2S administration in the regression of LVH by modulating oxidative stress, arterial stiffness and expression of cystathione γ lyase (CSE) in the myocardium. Animals were divided into four groups: Control, LVH, Control-H2S and LVH-H2S. LVH was induced by administering isoprenaline (5mg/kg, every 72 hours, S/C) and caffeine in drinking water (62mg/L) for 2 weeks...
2016: PloS One
https://www.readbyqxmd.com/read/26939834/hydrogen-sulphide-and-phosphine-interactions-with-human-skin-in-vitro
#14
Sharyn Gaskin, Linda Heath, Dino Pisaniello, Richard Evans, John W Edwards, Michael Logan, Christina Baxter
Accidental or intentional releases of toxic gases can have significant public health consequences and emergency resource demands. Management of exposed individuals during hazardous material incidents should be risk and evidence based, but there are knowledge gaps in relation to dermal absorption of gases and management advice for potentially exposed individuals. Using a modified Organization for Economic Co-operation and Development (OECD) in vitro toxicology protocol with human donor skin, this article reports on two common and odorous chemicals, hydrogen sulphide and phosphine...
April 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/26917598/liver-transplant-in-ethylmalonic-encephalopathy-a-new-treatment-for-an-otherwise-fatal-disease
#15
Carlo Dionisi-Vici, Daria Diodato, Giuliano Torre, Stefano Picca, Rosanna Pariante, Sergio Giuseppe Picardo, Ivano Di Meo, Cristiano Rizzo, Valeria Tiranti, Massimo Zeviani, Jean De Ville De Goyet
Ethylmalonic encephalopathy is a fatal, rapidly progressive mitochondrial disorder caused by ETHE1 mutations, whose peculiar clinical and biochemical features are due to the toxic accumulation of hydrogen sulphide and of its metabolites, including thiosulphate. In mice with ethylmalonic encephalopathy, liver-targeted adeno-associated virus-mediated ETHE1 gene transfer dramatically improved both clinical course and metabolic abnormalities. Reasoning that the same achievement could be accomplished by liver transplantation, we performed living donor-liver transplantation in an infant with ethylmalonic encephalopathy...
April 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/26660653/an-emerging-role-for-gasotransmitters-in-the-control-of-breathing-and-ionic-regulation-in-fish
#16
REVIEW
Steve Perry, Y Kumai, C S Porteus, V Tzaneva, R W M Kwong
Three gases comprising nitric oxide, carbon monoxide and hydrogen sulphide, collectively are termed gasotransmitters. The gasotransmitters control several physiological functions in fish by acting as intracellular signaling molecules. Hydrogen sulphide, first implicated in vasomotor control in fish, plays a critical role in oxygen chemoreception owing to its production and downstream effects within the oxygen chemosensory cells, the neuroepithelial cells. Indeed, there is emerging evidence that hydrogen sulphide may contribute to oxygen sensing in both fish and mammals by promoting membrane depolarization of the chemosensory cells...
February 2016: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/26593688/the-resurgence-of-phenotypic-screening-in-drug-discovery-and-development
#17
EDITORIAL
Bridget K Wagner
No abstract text is available yet for this article.
2016: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/26501040/erratum-to-combined-effect-of-hydrogen-sulphide-donor-and-losartan-in-experimental-diabetic-nephropathy-in-rats
#18
Manpreet Kaur, Shilpi Sachdeva, Onkar Bedi, Tavleen Kaur, Puneet Kumar
[This corrects the article DOI: 10.1186/s40200-015-0185-7.].
2015: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/26423279/thiosulphate-conversion-in-a-methane-and-acetate-fed-membrane-bioreactor
#19
Diego A Suarez-Zuluaga, Peer H A Timmers, Caroline M Plugge, Alfons J M Stams, Cees J N Buisman, Jan Weijma
The use of methane and acetate as electron donors for biological reduction of thiosulphate in a 5-L laboratory membrane bioreactor was studied and compared to disproportionation of thiosulphate as competing biological reaction. The reactor was operated for 454 days in semi-batch mode; 30 % of its liquid phase was removed and periodically replenished (days 77, 119, 166, 258, 312 and 385). Although the reactor was operated under conditions favourable to promote thiosulphate reduction coupled to methane oxidation, thiosulphate disproportionation was the dominant microbial process...
February 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/26283659/hydrogen-sulphide-and-mild-hypothermia-activate-the-creb-signaling-pathway-and-prevent-ischemia-reperfusion-injury
#20
Hai-bin Dai, Xiangjun Ji, Si-hai Zhu, Yi-min Hu, Li-dong Zhang, Xiao-lei Miao, Ru-Meng Ma, Man-lin Duan, Wei-yan Li
BACKGROUND: Both hydrogen sulphide (H2S) and mild hypothermia have been reported to prevent brain damage caused by reperfusion assault through regulating the N-methyl-D-aspartate receptor (NMDAR). However, the relationship between the two treatments and how they exert neuro-protective effects through NMDARs remain to be elucidated. METHODS: Transient cerebral ischemia was induced using the Pulsinelli four-vessel occlusion method. We used sodium hydrosulphide (NaHS) as the H2S donor...
2015: BMC Anesthesiology
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