Matthew R Hennefarth, Ling Chen, Bohan Wang, Tom F Lue, Marshall L Stoller, Guiting Lin, Misun Kang, Sunita P Ho
Spatiotemporal mechanobiology resulting in penile pathologies continues to be investigated using small scale animals models such as mice. However, species-dependent functional biomechanics of a mouse penis, is not known. In this study, spatial mapping of a mechanosensitive transcription factor, scleraxis (Scx), at ages 4, 5, 6 weeks, and 1 year were generated to identify mechanoactive regions within penile tissues. Reconstructed volumes of baculum collected using micro X-ray computed tomography illustrated significantly increased baculum length with decreased porosity, and increased mineral density (p < 0...
January 16, 2020: Journal of Biomechanics