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https://www.readbyqxmd.com/read/28331620/anger-and-aggression-in-borderline-personality-disorder-and-attention-deficit-hyperactivity-disorder-does-stress-matter
#1
Sylvia Cackowski, Annegret Krause-Utz, Julia Van Eijk, Katrin Klohr, Stephanie Daffner, Esther Sobanski, Gabriele Ende
BACKGROUND: The impact of stress on anger and aggression in Borderline Personality Disorder (BPD) and Attention Deficit Hyperactivity Disorder (ADHD) has not been thoroughly investigated. The goal of this study was to investigate different aspects of anger and aggression in patients with these disorders. METHODS: Twenty-nine unmedicated female BPD patients, 28 ADHD patients and 30 healthy controls (HC) completed self-reports measuring trait anger, aggression and emotion regulation capacities...
2017: Borderline Personality Disorder and Emotion Dysregulation
https://www.readbyqxmd.com/read/28328548/characterization-of-hiv-seroconverters-in-a-tdf-ftc-prep-study-hptn-067-adapt
#2
Mariya V Sivay, Maoji Li, Estelle Piwowar-Manning, Yinfeng Zhang, Sarah E Hudelson, Mark A Marzinke, Rivet K Amico, Andrew Redd, Craig W Hendrix, Peter L Anderson, Kevin Bokoch, Linda Gail-Bekker, Frits van Griensven, Sharon Mannheimer, James P Hughes, Robert Grant, Susan H Eshleman
BACKGROUND: HPTN 067/ADAPT evaluated tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) pre-exposure prophylaxis (PrEP) in women (South Africa) and men who have sex with men (Thailand, US). Participants received once-weekly directly observed TDF/FTC (DOT), and were then randomized to daily, time-driven, or event-driven PrEP. This report describes characterization of 12 HIV seroconversion events in this trial. METHODS: HIV rapid testing was performed at study sites...
March 22, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28314833/retinopathy-in-an-obesity-who-iii-cohort-prevalence-and-risk-factors
#3
Juri Mattern, Alexander Lammert, Mirko Otto, Hans-Peter Hammes
OBJECTIVE: To assess retinopathy and its risk factors in an obesity WHO III cohort. METHODS: In the Mannheim Obesity Study, 277 subjects with obesity WHO III aged 18-64 years were examined in a cross-sectional approach. Screening for retinopathy was performed using 3-field retinal photography. Endothelial function was assessed using arteriole-to-venule ratio and flicker light analysis. Subjects with and without retinopathy were analysed for anthropometry, metabolic, vascular and renal parameters...
March 17, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28293674/monitoring-and-analysis-of-the-change-process-in-curriculum-mapping-compared-to-the-national-competency-based-learning-objective-catalogue-for-undergraduate-medical-education-nklm-at-four-medical-faculties-part-i-conducive-resources-and-structures
#4
Maria Lammerding-Koeppel, Marianne Giesler, Maryna Gornostayeva, Elisabeth Narciss, Annette Wosnik, Stephan Zipfel, Jan Griewatz, Olaf Fritze
Objective: After passing of the National Competency-based Learning Objectives Catalogue in Medicine (Nationaler Kompetenzbasierter Lernzielkatalog Medizin, [NKLM, retrieved on 22.03.2016]), the German medical faculties must take inventory and develop their curricula. NKLM contents are expected to be present, but not linked well or sensibly enough in locally grown curricula. Learning and examination formats must be reviewed for appropriateness and coverage of the competences. The necessary curricular transparency is best achieved by systematic curriculum mapping, combined with effective change management...
2017: GMS Journal for Medical Education
https://www.readbyqxmd.com/read/28293673/monitoring-and-analysis-of-the-change-process-in-curriculum-mapping-compared-to-the-national-competency-based-learning-objective-catalogue-for-undergraduate-medical-education-nklm-at-four-medical-faculties-part-ii-key-factors-for-motivating-the-faculty-during
#5
Maria Lammerding-Koeppel, Marianne Giesler, Maryna Gornostayeva, Elisabeth Narciss, Annette Wosnik, Stephan Zipfel, Jan Griewatz, Olaf Fritze
Objective: After adoption of the National Competency-based Learning Objectives Catalogue in Medicine [Nationaler Kompetenzbasierter Lernzielkatalog Medizin, NKLM], the German medical faculties are asked to test the learning obejctives recorded in it and evaluate them critically. The faculties require curricular transparency for competence-oriented transition of present curricula, which is best achieved by systematic curriculum mapping in comparison to the NKLM. Based on this inventory, curricula can be further developed target-oriented...
2017: GMS Journal for Medical Education
https://www.readbyqxmd.com/read/28259509/early-antithrombotic-treatment-with-warfarin-oral-suspension-in-severe-neonatal-protein-c-deficiency
#6
C Milleret, C Epiard, S Douchin, G Pernod, T Debillon
Neonatal severe protein C deficiency is a serious disease. There is no uniform approach for long-term preventive treatment of thrombotic events. We report the case of neonatal severe protein C deficiency treated with warfarin oral suspension. An international normalized ratio (INR) from 2.5 to 3.5 was expected. The INR was measured by home monitoring using the Coaguchek XS(®) (Roche Diagnostics, Mannheim, Germany) monitor. During 2years of warfarin treatment, there were only two minor episodes of purpuric access and no bleeding was reported...
March 1, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28208908/comparison-of-carotid-intima-media-thickness-in-children-of-patients-with-and-without-premature-coronary-artery-disease
#7
Alagesan Murali, Anith Kumar Mambatta, R R M Ranganathan, R Shanmugasundaram, K Deepalakshmi
INTRODUCTION: Increased Carotid Intima Medial Thickness (CIMT) is associated with cardiovascular risk factors and vascular events like Coronary Artery Disease (CAD) and stroke. AIM: This study was designed to identify whether CIMT is increased in the children of parents with premature coronary artery disease and compare it with age and sex matched controls who are children of normal individuals. We also tried to compare and correlate the changes in CIMT if any, among the study group with relation to family history of diabetes and hypertension...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28126566/rapid-actions-of-aldosterone-revisited-receptors-in-the-limelight
#8
Martin Wehling
Steroid hormones like aldosterone have been conclusively shown to elicit both late genomic and rapid, nongenomically initiated responses. Aldosterone was among the first for which rapid, clinically relevant effects were even shown in humans. Yet, after over 30 years of research, the nature of receptors involved in rapid actions of aldosterone is still unclear. Such effects may be assigned to the classical, intracellular steroid receptors, in this case mineralocorticoid receptors (MR, class IIa action Mannheim classification)...
January 23, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28125691/health-related-quality-of-life-in-primary-care-which-aspects-matter-in-multimorbid-patients-with-type-2-diabetes-mellitus-in-a-community-setting
#9
Martina Kamradt, Johannes Krisam, Marion Kiel, Markus Qreini, Werner Besier, Joachim Szecsenyi, Dominik Ose
BACKGROUND AND OBJECTIVE: Knowledge about predictors of health-related quality of life for multimorbid patients with type 2 diabetes mellitus in primary care could help to improve quality and patient-centeredness of care in this specific group of patients. Thus, the aim of this study was to investigate the impact of several patient characteristics on health-related quality of life of multimorbid patients with type 2 diabetes mellitus in a community setting. RESEARCH DESIGN AND METHODS: A cross-sectional study with 32 primary care practice teams in Mannheim, Germany, and randomly selected multimorbid patients with type 2 diabetes mellitus (N = 495) was conducted...
2017: PloS One
https://www.readbyqxmd.com/read/28115978/high-fat-diet-modifies-the-association-of-lipoprotein-lipase-gene-polymorphism-with-high-density-lipoprotein-cholesterol-in-an-asian-indian-population
#10
K A Ayyappa, I Shatwan, D Bodhini, L R Bramwell, K Ramya, V Sudha, R M Anjana, J A Lovegrove, V Mohan, V Radha, K S Vimaleswaran
BACKGROUND: Single nucleotide polymorphisms (SNPs) in lipoprotein lipase gene (LPL) have been shown to influence metabolism related to lipid phenotypes. Dietary factors have been shown to modify the association between LPL SNPs and lipids; however, to date, there are no studies in South Asians. Hence, we tested for the association of four common LPL SNPs with plasma lipids and examined the interactions between the SNPs and dietary factors on lipids in 1,845 Asian Indians. METHODS: The analysis was performed in 788 Type 2 diabetes cases and 1,057 controls randomly chosen from the cross-sectional Chennai Urban Rural Epidemiological Study...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28100944/ostomy-in-nontraumatic-conditions-our-experience-and-review-of-the-literature
#11
Kenan Büyükaşık, Bünyamin Gürbulak, Emre Özoran, Yiğit Düzköylü, Esin Kabul Gürbulak, Aziz Arı, Hasan Bektaş
A number of nontraumatic acute abdomen can result in peritonitis leading to sepsis. In emergent conditions, various procedures like segmentary colectomy and/or subtotal colectomy with anastomosis, Hartmann's procedure, transverse colectomy, and/or expandable metallic stent (SEMS) placement can be performed, considering the status of the patient and the facilitaties of the institution. In our study, we examined the cases diagnosed as acute abdomen without the history of trauma, which had lead to a procedure requiring colostomy...
December 2016: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28089563/diagnostic-and-prognostic-relevance-of-magnetic-resonance-imaging-and-electrophysiological-findings-in-acute-spinal-ischemia
#12
Dimitrios Artemis, Marc Wolf, Christian Blahak, Kristina Szabo, Michael G Hennerici, Marc Fatar
OBJECTIVE: Our purpose was to classify the rare entity of spontaneous spinal ischemia with clinical, magnetic resonance-tomographic, and electrophysiological parameters to determine criteria for outcome prediction. METHODS: We analyzed the stroke registry database of the University Hospital Mannheim, Germany, from 2004 to 2010 for patients with a diagnosis of vascular spinal cord ischemia. RESULTS: Ten patients were identified (mean age 65 years [range 50-83], 5 women)...
January 12, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28058824/the-effect-of-amiodarone-on-warfarin-anticoagulation-a-register-based-nationwide-cohort-study-involving-the-swedish-population
#13
J Holm, J D Lindh, M L Andersson, B Mannheimer
Essentials Data on the effect of introducing amiodarone in patients already using warfarin regime are scarce. Information on 754 patients was extracted from three nationwide registers in Sweden. With amiodaron, 37% of patients had an international normalized ratio (INR) over 3.0 To avoid bleeding, the initiation of amiodarone should be accompanied by closer INR monitoring. SUMMARY: Background Data indicate that the interaction between warfarin and amiodarone results in an increased warfarin effect...
January 6, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28025918/outcomes-of-upper-airway-stimulation-for-obstructive-sleep-apnea-in-a-multicenter-german-postmarket-study
#14
Clemens Heiser, Joachim T Maurer, Benedikt Hofauer, J Ulrich Sommer, Annemarie Seitz, Armin Steffen
Objective Selective stimulation of the hypoglossal nerve is a new surgical therapy for obstructive sleep apnea, with proven efficacy in well-designed clinical trials. The aim of the study is to obtain additional safety and efficacy data on the use of selective upper airway stimulation during daily clinical routine. Study Design Prospective single-arm study. Setting Three tertiary hospitals in Germany (Munich, Mannheim, Lübeck). Subjects and Methods A multicenter prospective single-arm study under a common implant and follow-up protocol took place in 3 German centers (Mannheim, Munich, Lübeck)...
February 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28024813/perfluoroalkyl-substances-and-thyroid-hormones-in-cord-blood
#15
Meng-Shan Tsai, Ching-Chun Lin, Mei-Huei Chen, Wu-Shiun Hsieh, Pau-Chung Chen
BACKGROUND: Perfluoroalkyl substances (PFASs) are pollutants that tend to accumulate in the environment and organisms. The animal and human studies to date have focused on thyroid function, but the results are inconsistent. METHODS: A sample of 118 mother-infant pairs was obtained from the Taiwan Birth Panel Study (TBPS). Cord blood PFASs levels were evaluated using the Waters ACQUITY UPLC system coupled with a Waters Quattro Premier XE triple quadrupole mass spectrometer, and cord blood thyroid hormones were assessed using a Roche Analytics E170 modular analyser (Roche Diagnostics, Mannheim, Germany)...
March 2017: Environmental Pollution
https://www.readbyqxmd.com/read/27955872/laparoscopic-versus-open-repair-of-perforated-peptic-ulcer-improving-outcomes-utilizing-a-standardized-technique
#16
Sze Li Siow, Hans Alexander Mahendran, Chee Ming Wong, Mark Hardin, Tien Loong Luk
BACKGROUND/OBJECTIVE: The objective of this study was to compare the outcomes of patients who underwent laparoscopic and open repair of perforated peptic ulcers (PPUs) at our institution. METHODS: This is a retrospective review of a prospectively collected database of patients who underwent emergency laparoscopic or open repair for PPU between December 2010 and February 2014. RESULTS: A total of 131 patients underwent emergency repair for PPU (laparoscopic repair, n=63, 48...
December 7, 2016: Asian Journal of Surgery
https://www.readbyqxmd.com/read/27936098/analysis-of-hiv-diversity-in-hiv-infected-black-men-who-have-sex-with-men-hptn-061
#17
Iris Chen, Gordon Chau, Jing Wang, William Clarke, Mark A Marzinke, Vanessa Cummings, Autumn Breaud, Oliver Laeyendecker, Sheldon D Fields, Sam Griffith, Hyman M Scott, Steven Shoptaw, Carlos Del Rio, Manya Magnus, Sharon Mannheimer, Hong-Van Tieu, Darrell P Wheeler, Kenneth H Mayer, Beryl A Koblin, Susan H Eshleman
BACKGROUND: HIV populations often diversify in response to selective pressures, such as the immune response and antiretroviral drug use. We analyzed HIV diversity in Black men who have sex with men who were enrolled in the HIV Prevention Trials Network 061 study. METHODS: A high resolution melting (HRM) diversity assay was used to measure diversity in six regions of the HIV genome: two in gag, one in pol, and three in env. HIV diversity was analyzed for 146 men who were HIV infected at study enrollment, including three with acute infection and 13 with recent infection (identified using a multi-assay algorithm), and for 21 men who seroconverted during the study...
2016: PloS One
https://www.readbyqxmd.com/read/27918253/placental-growth-factor-alone-or-in-combination-with-soluble-fms-like-tyrosine-kinase-1-as-an-aid-to-the-assessment-of-women-with-suspected-pre-eclampsia-systematic-review-and-economic-analysis
#18
Geoff K Frampton, Jeremy Jones, Micah Rose, Liz Payne
BACKGROUND: Pre-eclampsia (PE) prediction based on blood pressure, presence of protein in the urine, symptoms and laboratory test abnormalities can result in false-positive diagnoses. This may lead to unnecessary antenatal admissions and preterm delivery. Blood tests that measure placental growth factor (PlGF) or the ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to PlGF could aid prediction of PE if either were added to routine clinical assessment or used as a replacement for proteinuria testing...
November 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27893676/combination-use-of-paclitaxel-and-avastin-enhances-treatment-effect-for-the-nsclc-patients-with-malignant-pleural-effusion
#19
Nan Qi, Fang Li, Xiaosong Li, Huanrong Kang, Hui Zhao, Nan Du
The current study is conducted to investigate efficacy of the chemotherapy drug paclitaxel in combination with Avastin (Roche Diagnostics GmbH., Mannheim, Germany) (antiangiogenic agent) in treatment of malignant pleural effusions (MPEs).Twenty-four patients with non-small cell lung cancer were randomly assigned for 2 treatment approaches. Ten patients received paclitaxel (175 mg/m) alone, and 14 patients took a combination therapy of paclitaxel and Avastin (5 mg/kg). Efficacy of the treatment approaches in the patients was validated with the change in the MPE volume...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27843277/assessment-of-severity-of-peritonitis-using-mannheim-peritonitis-index
#20
Sanjeev Sharma, Sumitoj Singh, Nikhil Makkar, Ashok Kumar, Mandeep Singh Sandhu
INTRODUCTION: Peritonitis is one of the most common problems in general surgery practice with high mortality rate. One of the reasons for high mortality is that peritonitis affects the general condition and leads to complications causing multiple organ failure, renal failure, sepsis, and postoperative ventilatory support. Early prognostic evaluation of patients with peritonitis is desirable to select high-risk patients for intensive management and also to provide a reliable objective classification of severity and operative risk...
July 2016: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
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