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https://www.readbyqxmd.com/read/29352759/regional-myocardial-function-abnormalities-are-associated-with-macro-and-microcirculation-dysfunction-in-the-metabolic-syndrome-the-resolve-study
#1
Philippe Obert, Guillaume Walther, Frédéric Dutheil, Bruno Lesourd, Robert Chapier, Daniel Courteix, Agnes Vinet
Abnormalities in myocardial and vascular function have been reported in the metabolic syndrome (MetS), but whether these alterations are related remains poorly documented. Our aim was accordingly to investigate interrelationships between macro- and microcirculatory vasoreactivity and left ventricular (LV) myocardial function in MetS patients. Eighty-eight MetS individuals and 44 age- and gender-matched healthy controls were enrolled. LV global longitudinal strain (GLS) was measured using Vector Velocity Imaging...
January 19, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29346085/performance-of-the-bioplex-2200-hiv-ag-ab-assay-for-identifying-acute-hiv-infection
#2
Susan H Eshleman, Estelle Piwowar-Manning, Mariya V Sivay, Barbara Debevec, Stephanie Veater, Laura McKinstry, Linda-Gail Bekker, Sharon Mannheimer, Robert M Grant, Margaret A Chesney, Thomas J Coates, Beryl A Koblin, Jessica M Fogel
BACKGROUND: Assays that detect HIV antigen (Ag) and antibody (Ab) can be used to screen for HIV infection. OBJECTIVES: To compare the performance of the BioPlex 2200 HIV Ag-Ab assay and two other Ag/Ab combination assays for detection of acute HIV infection. STUDY DESIGN: Samples were obtained from 24 individuals (18 from the US, 6 from South Africa); these individuals were classified as having acute infection based on the following criteria: positive qualitative RNA assay; two negative rapid tests; negative discriminatory test...
January 11, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29344846/evaluation-of-psychosocial-and-biological-parameters-in-women-seeking-for-a-caesarean-section-and-women-who-are-aiming-for-vaginal-delivery-a-cross-sectional-study
#3
Benjamin Tuschy, Sebastian Berlit, Paul Stützer, Stefanie Lis, Christian Schmahl, Ulf Baumgärtner, Marc Sütterlin
PURPOSE: To investigate psychosocial and biological parameters that may influence decision-making concerning the mode of delivery in women with caesarean section on maternal request (CSMR). METHODS: Two hundred and two women were enrolled prospectively. The study sample (n = 93) consisted of women who aimed for CSMR, the control sample were women who seeked for vaginal delivery (n = 109). Parturients of both samples were enrolled during the pre-birth counselling at the delivery room at the University Medical Centre Mannheim, University Heidelberg, Germany...
January 17, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29297098/evaluation-of-the-level-of-dynamic-thiol-disulphide-homeostasis-in-adolescent-patients-with-newly-diagnosed-primary-hypertension
#4
Evrim Kargın Çakıcı, Fehime Kara Eroğlu, Fatma Yazılıtaş, Mehmet Bülbül, Gökçe Gür, Özlem Aydoğ, Tülin Güngör, Özcan Erel, Murat Alışık, AtillaHalil Elhan
BACKGROUND: Thiol/disulphide homeostasis plays a critical role in numerous intracellular enzymatic pathways including antioxidant defense and detoxification. This study was designed to investigate the impact of thiol/disulfide homeostasis in adolescent patients with recently diagnosed primary hypertension (HT) using a novel and automated method. METHODS: Native thiol/disulphide levels were measured by a novel spectrophotometric method (Cobasc 501, Roche Diagnostics, Mannheim, Germany) in 30 patients with primary HT together with 30 healthy controls...
January 2, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29290377/reoperation-after-laparoscopic-colorectal-surgery-does-the-laparoscopic-approach-have-any-advantages
#5
Noelia Ibáñez, Jesús Abrisqueta, Juan Luján, Pedro Sánchez, María Teresa Soriano, Julio Arevalo-Pérez, Pascual Parrilla
INTRODUCTION: The laparoscopic approach in colorectal complications is controversial because of its difficulty. However, it has been proven that it can provide advantages over open surgery. The aim of this study is to compare laparoscopic approach in reoperations for complications after colorectal surgery with the open approach taking into account the severity of the patient prior to reoperation. METHODS: Patients who underwent laparoscopic colorectal surgery from January 2006 to December 2015 were retrospectively reviewed...
December 28, 2017: Cirugía Española
https://www.readbyqxmd.com/read/29260131/is-it-possible-to-reduce-the-surgical-mortality-and-morbidity-of-peptic-ulcer-perforations
#6
Adnan Hut, Cihad Tatar, Doğan Yıldırım, Turgut Dönmez, Akın Ünal, Ahmet Kocakuşak, Muzaffer Akıncı
Objective: Peptic ulcer perforation is a life-threatening situation requiring urgent surgical treatment. A novel vision in peptic ulcer perforation is necessary to fill the gaps created by antiulcer medication, aging of the patients, and presentation of resistant cases in our era. In this study, we aimed to share our findings regarding the effects of various risk factors and operative techniques on the mortality and morbidity of patients with peptic ulcer perforation. Material and Methods: Data from 112 patients presenting at our Training and Research Hospital Emergency Surgery Department between January 2010 and December 2015 who were diagnosed with PUP through physical examination and laboratory and radiological tests and operated at the hospital have been retrospectively analyzed...
2017: Turkish Journal of Surgery
https://www.readbyqxmd.com/read/29240004/synchronizing-gait-with-cardiac-cycle-phase-alters-heart-rate-response-during-running
#7
Keren Constantini, Abigail S L Stickford, Jeffery L Bleich, Paul D Mannheimer, Benjamin D Levine, Robert F Chapman
Timing foot strike to occur in synchrony with cardiac diastole may reduce left ventricular afterload and promote coronary and skeletal muscle perfusion. PURPOSE: To assess heart rate (HR) and metabolic responses to running when foot strikes are timed to occur exclusively during 1) the systolic phase of the cardiac cycle, or 2) the diastolic phase. METHODS: Ten elite male distance runners performed a testing session on a treadmill at 4.72 m[BULLET OPERATOR]s while matching their steps to an auditory tone and wearing a chest strap that transmitted accelerometer and ECG signals...
December 12, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29218064/non-diabetic-hyperglycemia-and-some-of-its-correlates-in-icu-hospitalized-patients-receiving-enteral-nutrition
#8
Mohammad Amin Valizadeh Hasanloei, Zahra Vahdat Shariatpanahi, Davoud Vahabzadeh, Zakaria Vahabzadeh, Leila Nasiri, Ali Shargh
Introduction: Hyperglycemia is a common occurrence in critically ill patients, and its prevalence in patients receiving nutritional support is much higher than in other patients. The non-diabetic form is associated with more undesirable outcomes. This study was performed to determine the prevalence of non-diabetic hyperglycemia and its correlates in patients receiving enteral nutrition. Material and Methods: This cross-sectional study was performed between March and December 2015...
September 2017: Mædica
https://www.readbyqxmd.com/read/29217019/effect-of-music-on-surgical-skill-during-simulated-intraocular-surgery
#9
RANDOMIZED CONTROLLED TRIAL
Ralph Kyrillos, Mathieu Caissie
OBJECTIVE: To evaluate the effect of Mozart music compared to silence on anterior segment surgical skill in the context of simulated intraocular surgery. DESIGN: Prospective stratified and randomized noninferiority trial. PARTICIPANTS: Fourteen ophthalmologists and 12 residents in ophthalmology. METHODS: All participants were asked to perform 4 sets of predetermined tasks on the EyeSI surgical simulator (VRmagic, Mannheim, Germany)...
December 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29188015/a-multi-disciplinary-perspective-on-emergent-and-future-innovations-in-peer-review
#10
REVIEW
Jonathan P Tennant, Jonathan M Dugan, Daniel Graziotin, Damien C Jacques, François Waldner, Daniel Mietchen, Yehia Elkhatib, Lauren B Collister, Christina K Pikas, Tom Crick, Paola Masuzzo, Anthony Caravaggi, Devin R Berg, Kyle E Niemeyer, Tony Ross-Hellauer, Sara Mannheimer, Lillian Rigling, Daniel S Katz, Bastian Greshake Tzovaras, Josmel Pacheco-Mendoza, Nazeefa Fatima, Marta Poblet, Marios Isaakidis, Dasapta Erwin Irawan, Sébastien Renaut, Christopher R Madan, Lisa Matthias, Jesper Nørgaard Kjær, Daniel Paul O'Donnell, Cameron Neylon, Sarah Kearns, Manojkumar Selvaraju, Julien Colomb
Peer review of research articles is a core part of our scholarly communication system. In spite of its importance, the status and purpose of peer review is often contested. What is its role in our modern digital research and communications infrastructure? Does it perform to the high standards with which it is generally regarded? Studies of peer review have shown that it is prone to bias and abuse in numerous dimensions, frequently unreliable, and can fail to detect even fraudulent research. With the advent of web technologies, we are now witnessing a phase of innovation and experimentation in our approaches to peer review...
2017: F1000Research
https://www.readbyqxmd.com/read/29180201/laparoscopic-repair-of-perforated-peptic-ulcer-simple-closure-versus-omentopexy
#11
COMPARATIVE STUDY
Being-Chuan Lin, Chien-Hung Liao, Shang-Yu Wang, Tsann-Long Hwang
BACKGROUND: This report presents our experience with laparoscopic repair performed in 118 consecutive patients diagnosed with a perforated peptic ulcer (PPU). We compared the surgical outcome of simple closure with modified Cellan-Jones omentopexy and report the safety and benefit of simple closure. METHODS: From January 2010 to December 2014, 118 patients with PPU underwent laparoscopic repair with simple closure (n = 27) or omentopexy (n = 91). Charts were retrospectively reviewed for demographic characteristics and outcome...
December 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29158146/monitoring-and-predicting-disease-activity-in-autoimmune-pancreatitis-with-the-m-annheim-aip-activity-score
#12
Michael Hirth, Miroslav Vujasinovic, Markus Münch, Christel Weiss, Matthias Löhr, Matthias P Ebert, Alexander Schneider
BACKGROUND & OBJECTIVES: Autoimmune pancreatitis (AiP) is treated by immunosuppressive therapy. Exact description of disease activity of AiP is essential in clinical practice and research, but a score to describe the disease activity is missing. Thus, we aimed to establish an activity score of AiP. METHODS: We retrospectively studied long-term disease courses of 29 patients with AiP (Mannheim, Germany), receiving corticosteroid treatment (CST) by analyzing 613 treatment appointments...
October 25, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29156877/comparison-of-microscopy-elisa-and-real-time-pcr-for-detection-of-giardia-intestinalis-in-human-stool-specimens
#13
Yunus Emre Beyhan, Zeynep Taş Cengiz
Background/aim: This study included patients who had digestive system complaints between August 2015 and October 2015. The research was designed to compare conventional microscopy with an antigen detection ELISA kit and the TaqMan-based real-time PCR (RT-PCR) technique for detection of Giardia intestinalis in human stool specimens. Materials and methods: Samples were concentrated by formalin-ether sedimentation technique and microscopic examinations were carried out on wet mount slides. A commercially available ELISA kit (Giardia CELISA, Cellabs, Brookvale, Australia) was used for immunoassay...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29143163/sex-prep-and-stigma-experiences-with-hiv-pre-exposure-prophylaxis-among-new-york-city-msm-participating-in-the-hptn-067-adapt-study
#14
Julie Franks, Yael Hirsch-Moverman, Avelino S Loquere, K Rivet Amico, Robert M Grant, Bonnie J Dye, Yan Rivera, Robert Gamboa, Sharon B Mannheimer
The HPTN 067/Alternative Dosing to Augment Pre-Exposure Prophylaxis Pill Taking (ADAPT) study evaluated daily and non-daily dosing schedules for oral pre-exposure prophylaxis (PrEP) to prevent HIV. A qualitative sub-study including focus groups and in-depth interviews was conducted among men who have sex with men participating in New York City to understand their experience with PrEP and study dosing schedules. The 37 sub-study participants were 68% black, 11% white, and 8% Asian; 27% were of Hispanic/Latino ethnicity...
November 15, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29110680/fraction-of-high-grade-cervical-intraepithelial-lesions-attributable-to-genotypes-targeted-by-a-nonavalent-hpv-vaccine-in-galicia-spain
#15
S Perez, A Iñarrea, R Pérez-Tanoira, M Gil, E López-Díez, O Valenzuela, M Porto, L Alberte-Lista, M A Peteiro-Cancelo, A Treinta, R Carballo, M C Reboredo, M E Alvarez-Argüelles, M J Purriños
BACKGROUND: Human papillomavirus (HPV) bivalent and quadrivalent vaccines have been widely implemented in worldwide organized immunization programs. A nonavalent HPV vaccine is now available in several countries. The objective was to describe the fraction of squamous non-invasive high-grade cervical intraepithelial lesions attributable to genotypes targeted by bi-quadrivalent vaccines and by nonavalent vaccine according to age and diagnosis in women living in the city of Vigo (Galicia, Spain)...
November 6, 2017: Virology Journal
https://www.readbyqxmd.com/read/28971332/standardization-of-small-animal-imaging-current-status-and-future-prospects
#16
REVIEW
Julia G Mannheim, Firat Kara, Janine Doorduin, Kerstin Fuchs, Gerald Reischl, Sayuan Liang, Marleen Verhoye, Felix Gremse, Laura Mezzanotte, Marc C Huisman
The benefit of small animal imaging is directly linked to the validity and reliability of the collected data. If the data (regardless of the modality used) are not reproducible and/or reliable, then the outcome of the data is rather questionable. Therefore, standardization of the use of small animal imaging equipment, as well as of animal handling in general, is of paramount importance. In a recent paper, guidance for efficient small animal imaging quality control was offered and discussed, among others, the use of phantoms in setting up a quality control program (Osborne et al...
October 2, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28957814/prevalence-and-incidence-of-autoimmune-pancreatitis-in-the-population-living-in-the-southwest-of-germany
#17
Alexander Schneider, Henrik Michaely, Christel Weiss, Michael Hirth, Felix Rückert, Torsten J Wilhelm, Stefan Schönberg, Alexander Marx, Manfred V Singer, J Matthias Löhr, Matthias P Ebert, Roland H Pfützer
BACKGROUND/AIMS: The prevalence and incidence of autoimmune pancreatitis (AiP) in those living in western countries are largely unknown. We aimed to determine the prevalence of AiP among patients with pancreatitis presenting to our tertiary referral center in Mannheim, Germany; and to estimate the incidence of AiP in the Southwest of Germany. METHODS: We performed a retrospective cross-sectional analysis and determined the prevalence of AiP in patients with acute pancreatitis (AP) or chronic pancreatitis (CP)...
September 29, 2017: Digestion
https://www.readbyqxmd.com/read/28947401/non-traumatic-acute-peritonitis-in-children-causes-and-prognosis-in-226%C3%A2-patients-at-the-national-hospital-of-zinder-niger
#18
H Adamou, O Habou, I Amadou-Magagi, M Doutchi, M Amadou, M Halidou
To report etiological and prognostic characteristics of acute peritonitis in children. This retrospective study reviewed the records for a 30-month period (January 2013-June 2015) at Zinder National Hospital (Niger) of all children between the ages of 0-15 years who underwent surgery for non-traumatic acute peritonitis. Statistical tests were performed, with significance defined by a P-value < 5 %. Acute peritonitis accounted for 62.12 % (226/358) of all emergency gastrointestinal surgery in children...
August 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28943323/hartmann-s-procedure-or-primary-anastomosis-for-generalized-peritonitis-due-to-perforated-diverticulitis-a-prospective-multicenter-randomized-trial-diverti
#19
Valerie Bridoux, Jean Marc Regimbeau, Mehdi Ouaissi, Muriel Mathonnet, Francois Mauvais, Estelle Houivet, Lilian Schwarz, Diane Mege, Igor Sielezneff, Charles Sabbagh, Jean-Jacques Tuech
BACKGROUND: About 25% of patients with acute diverticulitis require emergency intervention. Currently, most patients with diverticular peritonitis undergo a Hartmann's procedure. Our objective was to assess whether primary anastomosis (PA) with a diverting stoma results in lower mortality rates than Hartmann's procedure (HP) in patients with diverticular peritonitis. STUDY DESIGN: We conducted a multicenter randomized controlled trial conducted between June 2008 and May 2012: the DIVERTI (Primary vs Secondary Anastomosis for Hinchey Stage III-IV Diverticulitis) trial...
September 22, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28932873/-interventional-catheter-treatment-of-tricuspid-valve-regurgitation
#20
REVIEW
T Wißt, F Kreidel, M Schlüter, K-H Kuck, C Frerker
BACKGROUND: The tricuspid valve can be considered the "forgotten" valve because in the past hardly any research has been conducted in this field and as a result only few therapeutic options existed. The prognosis of untreated tricuspid regurgitation (TR) is poor and mortality is high for patients with severe TR. Patients frequently return to medical practices and hospitals because of cardiac decompensation, with shortness of breath and leg edema. OBJECTIVE: Recent years have seen more development in catheter-based treatment options...
November 2017: Der Internist
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