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Geoff K Frampton, Jeremy Jones, Micah Rose, Liz Payne
BACKGROUND: Pre-eclampsia (PE) prediction based on blood pressure, presence of protein in the urine, symptoms and laboratory test abnormalities can result in false-positive diagnoses. This may lead to unnecessary antenatal admissions and preterm delivery. Blood tests that measure placental growth factor (PlGF) or the ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to PlGF could aid prediction of PE if either were added to routine clinical assessment or used as a replacement for proteinuria testing...
November 2016: Health Technology Assessment: HTA
Nan Qi, Fang Li, Xiaosong Li, Huanrong Kang, Hui Zhao, Nan Du
The current study is conducted to investigate efficacy of the chemotherapy drug paclitaxel in combination with Avastin (Roche Diagnostics GmbH., Mannheim, Germany) (antiangiogenic agent) in treatment of malignant pleural effusions (MPEs).Twenty-four patients with non-small cell lung cancer were randomly assigned for 2 treatment approaches. Ten patients received paclitaxel (175 mg/m) alone, and 14 patients took a combination therapy of paclitaxel and Avastin (5 mg/kg). Efficacy of the treatment approaches in the patients was validated with the change in the MPE volume...
November 2016: Medicine (Baltimore)
Sanjeev Sharma, Sumitoj Singh, Nikhil Makkar, Ashok Kumar, Mandeep Singh Sandhu
INTRODUCTION: Peritonitis is one of the most common problems in general surgery practice with high mortality rate. One of the reasons for high mortality is that peritonitis affects the general condition and leads to complications causing multiple organ failure, renal failure, sepsis, and postoperative ventilatory support. Early prognostic evaluation of patients with peritonitis is desirable to select high-risk patients for intensive management and also to provide a reliable objective classification of severity and operative risk...
July 2016: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
Ebba Elisabeth Mannheimer, Lene Holm Harritshøj, Terese Lea Katzenstein
Hepatitis E virus (HEV) infection among pregnant women is severe, often leading to fulminant hepatic failure and death, with mortality rates up to 15-25%. Studies suggest that differences in genotypes/subgenotypes, hormonal and immunological changes during pregnancy may contribute to the severe consequences for pregnant women with HEV. Although the increased mortality among pregnant women predominantly is seen in developing countries where genotype 1 is endemic, there are also large differences in mortality among pregnant women within these countries...
October 10, 2016: Ugeskrift for Laeger
Susanne Eigl, Martin Hoenigl, Birgit Spiess, Sven Heldt, Juergen Prattes, Peter Neumeister, Albert Wolfler, Jasmin Rabensteiner, Florian Prueller, Robert Krause, Mark Reinwald, Holger Flick, Dieter Buchheidt, Tobias Boch
In recent years galactomannan antigen testing (GM) and also Aspergillus PCR have become increasingly important for diagnosis of invasive aspergillosis (IA). Whether or not these tests need to be performed with bronchoalveolar lavage fluid (BALF; i.e., primary site of infection), or testing of blood samples is sufficient, remains, however, a matter of debate. We evaluated the diagnostic performance of GM ELISA, and Aspergillus PCR by using BALF samples and blood samples obtained at the same day from a total of 53 immunocompromised patients (16 with probable/proven IA and 37 with no evidence of IA according to the revised EORTC/MSG criteria; 38 patients with hematological malignancies were prospectively enrolled at the Medical University of Graz, Austria, 15 patients with mixed underlying diseases at the Mannheim University Hospital)...
October 14, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Galit Zeluf, Cecilia Dhejne, Carolina Orre, Louise Nilunger Mannheimer, Charlotte Deogan, Jonas Höijer, Anna Ekéus Thorson
No abstract text is available yet for this article.
October 14, 2016: BMC Public Health
Galit Zeluf, Cecilia Dhejne, Carolina Orre, Louise Nilunger Mannheimer, Charlotte Deogan, Jonas Höijer, Anna Ekéus Thorson
BACKGROUND: Swedish research concerning the general health of trans people is scarce. Despite the diversity of the group, most Swedish research has focused on gender dysphoric people seeking medical help for their gender incongruence, or on outcomes after medical gender-confirming interventions. This paper examines self-rated health, self-reported disability and quality of life among a diverse group of trans people including trans feminine, trans masculine, and gender nonbinary people (identifying with a gender in between male of female, or identify with neither of these genders) as well as people self-identifying as transvestites...
August 30, 2016: BMC Public Health
A Krause-Utz, S Cackowski, S Daffner, Esther Sobanski, Michael M Plichta, M Bohus, G Ende, C Schmahl
BACKGROUND: Impulsivity is a core feature of borderline personality disorder (BPD) and attention deficit hyperactivity disorder (ADHD). In BPD, impulsive behavior primarily occurs under acute stress; impulse control deficits under non-stress conditions may be partly related to co-morbid ADHD. We aimed to investigate whether acute experimental stress has an impact on self-reported impulsivity, response inhibition (action withholding, action cancelation) and delay discounting in BPD compared to ADHD...
August 30, 2016: Psychological Medicine
J S Biedermann, A M van den Besselaar, F W Leebeek, M J Kruip
No abstract text is available yet for this article.
August 27, 2016: Journal of Thrombosis and Haemostasis: JTH
Steven Brandt, Rudi Roose, Griet Verschelden
From the late 1980s until now, scholars, educators and social workers have criticised the diminution of interest in the structural level of social problems. In this lament, former social work is beguiled, while critiques are targeted at the new generation of social workers. These critiques forewarn of important issues and problems, but at the same time they portray social work in a devolutionary way. It is argued that this one-sided debate conceals frictions between different generations of social workers. In reference to the work of Karl Mannheim, an intergenerational perspective is proposed that goes beyond nostalgic relishing of the past and calls on social work to actively engage with past remembrance and present evolutions...
July 2016: British Journal of Social Work
Marc N Jarczok, Julian Koenig, Jian Li, Daniel Mauss, Kristina Hoffmann, Burkhard Schmidt, Joachim E Fischer, Julian F Thayer
BACKGROUND: Work stress is associated with an increased risk of pre-diabetes, Type 2 diabetes, and inflammation, as well as decreased autonomic nervous system function as measured, for example, via heart rate variability. We investigated the extent to which the association between work stress and glycemic status is mediated by vagally-mediated heart rate variability (vmHRV) and/or inflammation. METHODS: Cross-sectional data from the Mannheim Industrial Cohort Study (MICS) with 9,937 participants were analyzed...
2016: PloS One
R E Bernardi, K Zohsel, N Hirth, J Treutlein, M Heilig, M Laucht, R Spanagel, W H Sommer
It has been proposed that vulnerability to nicotine addiction is moderated by variation at the μ-opioid receptor locus (OPRM1), but results from human studies vary and prospective studies based on genotype are lacking. We have developed a humanized mouse model of the most common functional OPRM1 polymorphism rs1799971_A>G (A118G). Here we use this model system together with a cohort of German youth to examine the role of the OPRM1 A118G variation on nicotine reward. Nicotine reinforcement was examined in the humanized mouse model using i...
2016: Translational Psychiatry
N N Krylov, O V Babkin, D O Babkin
AIM: to define the correlation between Mannheim peritonitis index scores and outcomes of different radical and palliative interventions for perforative duodenal ulcer. MATERIAL AND METHODS: Treatment of 386 patients with perforative duodenal ulcer is presented. Different surgical techniques were analyzed including stomach resection, various methods of vagotomy with/without drainage, ulcer suturing and ulcerative edges excision with suturing in patients with Mannheim index scores <21, 21-29 and over 29...
2016: Khirurgiia
Josephine Ho, Raylene A Reimer, Manpreet Doulla, Carol Huang
BACKGROUND: The gut microbiome is increasingly recognized as a contributor to disease states. Patients with type 1 diabetes (DM1) have distinct gut microbiota in comparison to non-diabetic individuals, and it has been linked to changes in intestinal permeability, inflammation and insulin resistance. Prebiotics are non-digestible carbohydrates that alter gut microbiota and could potentially improve glycemic control in children with DM1. This pilot study aims to determine the feasibility of a 12-week dietary intervention with prebiotics in children with DM1...
July 26, 2016: Trials
F Sudbrock, A Herrmann, T Fischer, B Zimmermanns, W Baus, A Drzezga, K Schomäcker
The protective effect of stable iodide against radiation on thyroid cells was investigated. One physiological effect of stable iodine is well-rooted: stable iodine leads to a reduced thyroid uptake of radioactive iodine. This work wants to focus on an intrinsic effect of stable iodine by which DNA-damage in cells is prevented. To investigate this intrinsic effect thyroid cells (FRTL-5) were externally irradiated by use of a linear accelerator (LINAC) applying energy doses of 0.01 Gy-400 Gy and by incubation with various activity concentrations of (131)I (0...
January 2017: Journal of Environmental Radioactivity
M Sohn, A Agha, W Heitland, F Gundling, P Steiner, I Iesalnieks
BACKGROUND: The best surgical strategy for the management of perforated diverticulitis with generalized peritonitis of the sigmoid colon is not clearly defined. The aim of this retrospective cohort study was to evaluate the value of a damage control strategy. METHODS: All patients who underwent emergency laparotomy for perforated diverticular disease of the sigmoid colon with generalized peritonitis between 2010 and 2015 were included. The damage control strategy (study group), included a two- stage procedure: limited resection of the diseased colonic segment, closure of proximal colon and distal stump, and application of an abdominal vacuum at the initial surgery followed by second-look laparotomy 24-48 h later At this point a choice was made between anastomosis and Hartmann's procedure...
August 2016: Techniques in Coloproctology
Daniel Shu Wei Ting, Shaun Sebastian Khung Peng Sim, Christine Wen Leng Yau, Mohamad Rosman, Ai Tee Aw, Ian Yew San Yeo
This is a review education paper on the current ophthalmology simulators utilized worldwide for undergraduate and postgraduate training. At present, various simulators such as the EYE Exam Simulator (Kyoto Kagaku Co. Ltd., Kyoto, Japan), Eyesi direct ophthalmoscope simulator (VRmagic, GmbH, Mannheim, Germany), Eyesi indirect ophthalmoscope simulator (VRmagic, GmbH, Mannheim, Germany) and Eyesi cataract simulators (VRmagic, GmbH, Mannheim, Germany). These simulators are thought to be able to reduce the initial learning curve for the ophthalmology training but further research will need to be conducted to assess the effectiveness of the simulation-assisted Ophthalmology training...
2016: International Journal of Ophthalmology
Keren Constantini, Abby S Stickford, Jeffery L Bleich, Paul D Mannheimer, Benjamin D Levine, Robert F Chapman
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
I El-Battrawy, M Behnes, U Ansari, D Hillenbrand, D Haghi, U Hoffmann, T Papavassiliu, E Elmas, C Fastner, T Becher, S Baumann, C Dösch, F Heggemann, J Kuschyk, M Borggrefe, I Akin
BACKGROUND: Takotsubo cardiomyopathy (TTC) is a relevant differential diagnosis in patients presenting with signs of an acute coronary syndrome. Although recent literature has highlighted some salient features of this disorder, there has been little information elucidating the differences in clinical features, electrocardiographic findings, echocardiographic data and TTC-related complications associated with the different variants of TTC. METHODS AND RESULTS: Our institutional database constituted a collective of 114 patients diagnosed with TTC between 2003 and 2015 and these patients were subsequently divided into two groups based on the presence (n = 82, 72%) or absence (n = 32, 28%) of the apical form of TTC...
June 24, 2016: QJM: Monthly Journal of the Association of Physicians
Marco Degidi, Gianni Caligiana, Daniela Francia, Alfredo Liverani, Giorgio Olmi, Francesco Tornabene
Over the past decades, the technological development in the medical field, coupled with the ongoing scientific research, has led to the development and improvement of dental prostheses supported by screw-retained metal frameworks. A key point in the manufacture of the framework is the achievement of a passive fit, intended as the capability of an implant-supported reconstruction to transmit minimum strain to implant components as well as to the surrounding bone, when subject to any load. The fitting of four different kinds of screw-retained metal frameworks was tested in this article...
June 23, 2016: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
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