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Julie Franks, Sharon B Mannheimer, Yael Hirsch-Moverman, Eleanor Hayes-Larson, Paul W Colson, Hugo Ortega, Wafaa M El-Sadr
INTRODUCTION: Black men who have sex with men and transgender women are at high risk for HIV infection, but are more likely to be unaware of their infection or not in care for diagnosed HIV compared to other races. Respondent driven sampling has been advanced as a method to reach stigmatized and hidden populations for HIV testing. We compared strategies to recruit black, substance-using men who have sex with men and transgender women to identify newly diagnosed HIV infection, or those previously diagnosed but not in care...
March 2018: Journal of the International AIDS Society
M A Sohn, A Agha, P Steiner, A Hochrein, M Komm, R Ruppert, P Ritschl, F Aigner, I Iesalnieks
PURPOSE: Damage control strategy (DCS) is a two-staged procedure for the treatment of perforated diverticular disease complicated by generalized peritonitis. The aim of this retrospective multicenter cohort study was to evaluate the prognostic impact of an ongoing peritonitis at the time of second surgery. METHODS: Consecutive patients who underwent DCS for perforated diverticular disease of the sigmoid colon with generalized peritonitis at four surgical centers were included...
March 13, 2018: International Journal of Colorectal Disease
Henry Anyimadu, Chandra Pingili, Vel Sivapalan, Yael Hirsch-Moverman, Sharon Mannheimer
Current guidelines suggest that HIV-infected patients should receive chemoprophylaxis against Pneumocystis jirovecii pneumonia (PJP) if they have a cluster determinant 4 (CD4) count <200 cells/mm3 or oropharyngeal candidiasis. Persons with CD4 percentage (CD4%) below 14% should also be considered for prophylaxis. Discordance between CD4 count and CD4% occurs in 16% to 25% of HIV-infected patients. Provider compliance with current PJP prophylaxis guidelines when such discordance is present was assessed. Electronic medical records of 429 HIV-infected individuals who had CD4 count and CD4% measured at our clinic were reviewed...
January 2018: Journal of the International Association of Providers of AIDS Care
Johannes Breyer, Ralph M Wirtz, Philipp Erben, Thomas S Worst, Robert Stoehr, Markus Eckstein, Simone Bertz, Danijel Sikic, Stefan Denzinger, Maximilian Burger, Arndt Hartmann, Wolfgang Otto
BACKGROUND: A recent study on the comprehensive genomic profile of advanced urothelial bladder cancer (UBC) showed cyclin-dependent kinase inhibitor 2A (CDKN2A) and fibroblast growth factor receptor 3 (FGFR3) as the most often clinically relevant genomic alterations. Therefore, the prognostic role of FGFR3 and CDKN2A/p16 for pT1 UBC was studied. PATIENTS AND METHODS: Clinical data and formalin-fixed paraffin-embedded tissues of pT1 UBC treated with an organ-preserving approach was analyzed retrospectively...
February 2, 2018: Clinical Genitourinary Cancer
Volker Gebhardt, Vera Zawierucha, Oliver Schöffski, Anke Schwarz, Christel Weiss, Marc D Schmittner
BACKGROUND: Both general and spinal anaesthesia with short-acting local anaesthetics are suitable and reliable for knee arthroscopy as an ambulatory procedure. Chloroprocaine (CP) 1% seems to be the ideal spinal local anaesthetic for this indication. OBJECTIVE: The aim of this study was to compare spinal anaesthesia using CP 1% with general for outpatient knee arthroscopy with regard to procedure times, occurrence of pain, patient satisfaction and recovery, and also costs...
March 7, 2018: European Journal of Anaesthesiology
Enrico Rubaltelli, Sara Scrimin, Ughetta Moscardino, Giulia Priolo, Giulia Buodo
Terrorist attacks have a destabilizing impact on the general population, causing distress and fear. However, not all individuals are equally susceptible to the effects of terror threat. This study aimed to examine whether exposure to terrorism-related pictures interacted with individual differences in environmental sensitivity and psychophysiological response to stress to explain people's risk perception, operationalized as perceived likelihood of a terrorist attack and willingness to trade off one's privacy to increase national security...
March 2, 2018: British Journal of Psychology
Martin Dusch, Elisabeth Narciß, Renate Strohmer, Katrin Schüttpelz-Brauns
Aim: As part of the MaReCuM model curriculum at Medical Faculty Mannheim Heidelberg University, a final year rotation in ambulatory care was implemented and augmented to include ambulatory care simulation. In this paper we describe this ambulatory care simulation, the designated competency-based learning objectives, and evaluate the educational effect of the ambulatory care simulation training. Method: Seventy-five final year medical students participated in the survey (response rate: 83%). The control group completed the ambulatory rotation prior to the implementation of the ambulatory care simulation...
2018: GMS Journal for Medical Education
Lee P Ferguson, Phuoc Duong, Kim F Pearce, Paul Murphy, Tina T Biss
The optimal method for monitoring antiplatelet therapy in children supported with ventricular assist devices (VADs) is unknown. We conducted a retrospective study to compare Thromboelastography Platelet Mapping (TEG/PM) with multiple electrode platelet aggregometry (MEA) on a Multiplate analyzer (Roche Diagnostics, Mannheim, Germany). We analyzed data from 66 paired blood samples from 9 patients <16 years of age on VAD where platelet function was simultaneously measured with TEG/PM and MEA. Antiplatelet dose-response relationships and intraindividual variability during steady state therapy were determined...
February 27, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Hanah Kim, Mina Hur, Eunsin Bae, Kyung-A Lee, Woo-In Lee
BACKGROUND: Hepatitis B virus (HBV) nucleic acid amplification testing (NAAT) is important for the diagnosis and management of HBV infection. We evaluated the analytical performance of the cobas HBV NAAT (Roche Diagnostics GmbH, Mannheim, Germany) on the cobas 4800 System in comparison with COBAS AmpliPrep/COBAS TaqMan HBV Test (CAP/CTM HBV). METHODS: Precision was evaluated using three levels of cobas HBV/HCV/HIV-1 Control Kit, and linearity was evaluated across the anticipated measuring range (10...
February 19, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
Birgitta Johansson, Anna-Pia Wentzel, Paulin Andréll, Lars Rönnbäck, Clas Mannheimer
No abstract text is available yet for this article.
February 8, 2018: Journal of Clinical Psychopharmacology
Kate M Mitchell, Dobromir Dimitrov, James P Hughes, Fan Xia, Deborah Donnell, K Rivet Amico, Kevin Bokoch, Anupong Chitwarakorn, Linda-Gail Bekker, Timothy H Holtz, Sharon Mannheimer, Robert M Grant, Marie-Claude Boily
OBJECTIVES: To review the main factors influencing the costs of nondaily oral preexposure prophylaxis (PrEP) with tenofovir (±emtricitabine). To estimate the cost reductions possible with nondaily PrEP compared with daily PrEP for different populations (MSM and heterosexual populations). DESIGN: Systematic review and data triangulation. METHODS: We estimated the required number of tablets/person/week for dosing regimens used in the HPTN 067/ADAPT (daily/time-driven/event-driven) and IPERGAY (on-demand) trials for different patterns of sexual intercourse...
February 8, 2018: AIDS
Robert M Grant, Sharon Mannheimer, James P Hughes, Yael Hirsch-Moverman, Avelino Loquere, Anupong Chitwarakorn, Marcel E Curlin, Maoji Li, K Rivet Amico, Craig W Hendrix, Peter L Anderson, Bonnie J Dye, Mark A Marzinke, Estelle Piwowar-Manning, Laura McKinstry, Vanessa Elharrar, Michael Stirratt, James F Rooney, Susan H Eshleman, Janet M McNicholl, Frits van Griensven, Timothy H Holtz
Background: Nondaily dosing of oral preexposure prophylaxis (PrEP) may provide equivalent coverage of sex events compared with daily dosing. Methods: At-risk men and transgender women who have sex with men were randomly assigned to 1 of 3 dosing regimens: 1 tablet daily, 1 tablet twice weekly with a postsex dose (time-driven), or 1 tablet before and after sex (event-driven), and were followed for coverage of sex events with pre- and postsex dosing measured by weekly self-report, drug concentrations, and electronic drug monitoring...
February 6, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Jose R Castillo-Mancilla, Andrew N Phillips, James D Neaton, Jacqueline Neuhaus, Simon Collins, Sharon Mannheimer, Sarah Pett, Veronique Touzeau-Römer, Mark N Polizzotto, Jens D Lundgren, Edward M Gardner
Suboptimal (ie, <100%) antiretroviral therapy (ART) adherence has been associated with heightened inflammation in cohort studies, even among people with virologic suppression. We aimed to evaluate this association among participants in the Strategies for Management of Antiretroviral Therapy (SMART) study who had virologic suppression (HIV-1 VL < 200 copies/mL) at enrollment. Based on self-reported adherence (7-day recall), plasma concentrations of interleukin 6 and D-dimer were 9% (95% confidence interval [CI], 1%-18%; P = ...
January 2018: Open Forum Infectious Diseases
Philippe Obert, Guillaume Walther, Frédéric Dutheil, Bruno Lesourd, Robert Chapier, Daniel Courteix, Agnes Vinet
Abnormalities in myocardial and vascular function have been reported in the metabolic syndrome (MetS), but whether these alterations are related remains poorly documented. Our aim was accordingly to investigate interrelationships between macro- and microcirculatory vasoreactivity and left ventricular (LV) myocardial function in MetS patients. Eighty-eight MetS individuals and 44 age- and gender-matched healthy controls were enrolled. LV global longitudinal strain (GLS) was measured using Vector Velocity Imaging...
January 19, 2018: Heart and Vessels
Susan H Eshleman, Estelle Piwowar-Manning, Mariya V Sivay, Barbara Debevec, Stephanie Veater, Laura McKinstry, Linda-Gail Bekker, Sharon Mannheimer, Robert M Grant, Margaret A Chesney, Thomas J Coates, Beryl A Koblin, Jessica M Fogel
BACKGROUND: Assays that detect HIV antigen (Ag) and antibody (Ab) can be used to screen for HIV infection. OBJECTIVES: To compare the performance of the BioPlex 2200 HIV Ag-Ab assay and two other Ag/Ab combination assays for detection of acute HIV infection. STUDY DESIGN: Samples were obtained from 24 individuals (18 from the US, 6 from South Africa); these individuals were classified as having acute infection based on the following criteria: positive qualitative RNA assay; two negative rapid tests; negative discriminatory test...
January 11, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Benjamin Tuschy, Sebastian Berlit, Paul Stützer, Stefanie Lis, Christian Schmahl, Ulf Baumgärtner, Marc Sütterlin
PURPOSE: To investigate psychosocial and biological parameters that may influence decision-making concerning the mode of delivery in women with caesarean section on maternal request (CSMR). METHODS: Two hundred and two women were enrolled prospectively. The study sample (n = 93) consisted of women who aimed for CSMR, the control sample were women who seeked for vaginal delivery (n = 109). Parturients of both samples were enrolled during the pre-birth counselling at the delivery room at the University Medical Centre Mannheim, University Heidelberg, Germany...
January 17, 2018: Archives of Gynecology and Obstetrics
Evrim Kargın Çakıcı, Fehime Kara Eroğlu, Fatma Yazılıtaş, Mehmet Bülbül, Gökçe Gür, Özlem Aydoğ, Tülin Güngör, Özcan Erel, Murat Alışık, AtillaHalil Elhan
BACKGROUND: Thiol/disulphide homeostasis plays a critical role in numerous intracellular enzymatic pathways including antioxidant defense and detoxification. This study was designed to investigate the impact of thiol/disulfide homeostasis in adolescent patients with recently diagnosed primary hypertension (HT) using a novel and automated method. METHODS: Native thiol/disulphide levels were measured by a novel spectrophotometric method (Cobasc 501, Roche Diagnostics, Mannheim, Germany) in 30 patients with primary HT together with 30 healthy controls...
January 2, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Noelia Ibáñez, Jesús Abrisqueta, Juan Luján, Pedro Sánchez, María Teresa Soriano, Julio Arevalo-Pérez, Pascual Parrilla
INTRODUCTION: The laparoscopic approach in colorectal complications is controversial because of its difficulty. However, it has been proven that it can provide advantages over open surgery. The aim of this study is to compare laparoscopic approach in reoperations for complications after colorectal surgery with the open approach taking into account the severity of the patient prior to reoperation. METHODS: Patients who underwent laparoscopic colorectal surgery from January 2006 to December 2015 were retrospectively reviewed...
December 28, 2017: Cirugía Española
Adnan Hut, Cihad Tatar, Doğan Yıldırım, Turgut Dönmez, Akın Ünal, Ahmet Kocakuşak, Muzaffer Akıncı
Objective: Peptic ulcer perforation is a life-threatening situation requiring urgent surgical treatment. A novel vision in peptic ulcer perforation is necessary to fill the gaps created by antiulcer medication, aging of the patients, and presentation of resistant cases in our era. In this study, we aimed to share our findings regarding the effects of various risk factors and operative techniques on the mortality and morbidity of patients with peptic ulcer perforation. Material and Methods: Data from 112 patients presenting at our Training and Research Hospital Emergency Surgery Department between January 2010 and December 2015 who were diagnosed with PUP through physical examination and laboratory and radiological tests and operated at the hospital have been retrospectively analyzed...
2017: Turkish Journal of Surgery
Keren Constantini, Abigail S L Stickford, Jeffery L Bleich, Paul D Mannheimer, Benjamin D Levine, Robert F Chapman
Timing foot strike to occur in synchrony with cardiac diastole may reduce left ventricular afterload and promote coronary and skeletal muscle perfusion. PURPOSE: To assess heart rate (HR) and metabolic responses to running when foot strikes are timed to occur exclusively during 1) the systolic phase of the cardiac cycle, or 2) the diastolic phase. METHODS: Ten elite male distance runners performed a testing session on a treadmill at 4.72 m[BULLET OPERATOR]s while matching their steps to an auditory tone and wearing a chest strap that transmitted accelerometer and ECG signals...
December 12, 2017: Medicine and Science in Sports and Exercise
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