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https://www.readbyqxmd.com/read/29471583/national-partnership-for-maternal-safety-consensus-bundle-on-safe-reduction-of-primary-cesarean-births-supporting-intended-vaginal-births
#1
David C Lagrew, Lisa Kane Low, Rita Brennan, Maureen P Corry, Joyce K Edmonds, Brian G Gilpin, Jennifer Frost, Whitney Pinger, Dale P Reisner, Sara Jaffer
Cesarean births and associated morbidity and mortality have reached near epidemic proportions. The National Partnership for Maternal Safety under the guidance of the Council on Patient Safety in Women's Health Care responded by developing a patient safety bundle to reduce the number of primary cesarean births. Safety bundles outline critical practices to implement in every maternity unit. This National Partnership for Maternity Safety bundle, as with other bundles, is organized into four domains: Readiness, Recognition and Prevention, Response, and Reporting and Systems Learning...
February 22, 2018: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/29471539/breaking-down-barriers-to-the-utilization-of-standardized-tests-and-outcome-measures-in-acute-care-physical-therapist-practice-an-observational-longitudinal-study
#2
Brian McDonnell, Shannon Stilwell, Shelby Hart, Roger B Davis
Background: Standardized tests and outcome measures (STOM) have not been consistently implemented as part of most physical therapists' practice. Incidence of STOM use amongst physical therapists at Beth Israel Deaconess Medical Center was similar to low levels cited nationally among acute care physical therapists. Targeted knowledge translation (KT) strategies have been suggested to promote the application of research evidence into clinical decision making. Purpose: The purpose of this quality improvement (QI) effort was to implement a series of interventions aimed at increasing both use and interpretation of STOM by physical therapists practicing in acute care...
February 19, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29471393/the-severe-impairment-profile-a-conceptual-shift
#3
Jordan S Robinson, Robert L Collins, Brian I Miller, Vitor H Pacheco, Nicholas M Wisdom
Objective: The current study sought to evaluate and replicate the severe impairment profile (SIP) of the Word Memory Test (WMT) in patients referred for dementia evaluations. Method: The sample consisted of 125 patients referred for a neuropsychological evaluation at a large Veterans Affairs Medical Center. Patients were assigned a Clinical Dementia Rating (CDR) by blind raters, and were classified according to their performance on performance validity testing. Subsequent chart reviews were conducted to help in more accurately determining the presence of severe memory impairment likely due to an underlying dementing process versus poor effort/task engagement...
March 1, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29471381/efficacy-of-vedolizumab-in-fistulising-crohn-s-disease-exploratory-analyses-of-data-from-gemini-2
#4
Brian G Feagan, David Schwartz, Silvio Danese, David T Rubin, Trevor W Lissoos, Jing Xu, Karen Lasch
Background and Aims: Medical management of fistulising Crohn's disease (CD) is constrained by the limited number of available therapies. We evaluated the efficacy of vedolizumab, a gut-selective α4β7 integrin antagonist approved for treating moderately to severely active CD, in a subpopulation of patients with fistulising CD who participated in the GEMINI 2 trial (NCT00783692). Methods: Exploratory analyses of data from the GEMINI 2 trial were conducted in 461 responders to 6-week vedolizumab induction therapy who received maintenance placebo (VDZ/PBO, N=153) or vedolizumab (VDZ/VDZ, N=308)...
February 17, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29471255/non-stop-aptasensor-capable-of-rapidly-monitoring-norovirus-in-a-sample
#5
Brian Kim, Kang Wook Chung, Ji Hoon Lee
A cost-effective and simple biosensor was developed for the accurate and rapid monitoring of norovirus GII in a sample. The modified DNA aptamer, 5 guanines linked to conventional DNA aptamer, designed for the research, was able to rapidly capture norovirus GII in tap water as well artificial urine. In addition, the extra guanines of the modified DNA aptamer enhanced the sensitivity of biosensor with guanine chemiluminescence detection based on the principle of intra chemiluminescent resonance transfer (Intra-CRET)...
February 11, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29471191/peak-knee-biomechanics-and-limb-symmetry-following-unilateral-anterior-cruciate-ligament-reconstruction-associations-of-walking-gait-and-jump-landing-outcomes
#6
Steven J Pfeiffer, J Troy Blackburn, Brittney Luc-Harkey, Matthew S Harkey, Laura E Stanley, Barnett Frank, Darin Padua, Stephen W Marshall, Jeffrey T Spang, Brian Pietrosimone
BACKGROUND: Aberrant walking-gait and jump-landing biomechanics may influence the development of post-traumatic osteoarthritis and increase the risk of a second anterior cruciate ligament injury, respectively. It remains unknown if individuals who demonstrate altered walking-gait biomechanics demonstrate similar altered biomechanics during jump-landing. Our aim was to determine associations in peak knee biomechanics and limb-symmetry indices between walking-gait and jump-landing tasks in individuals with a unilateral anterior cruciate ligament reconstruction...
January 31, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29471035/how-safe-is-the-safety-net-comparison-of-ivor-lewis-esophagectomy-at-a-safety-net-hospital-using-the-nsqip-database
#7
Lori A Gurien, Joseph J Tepas, D Scott Lind, David J Chesire, Michel J Sabra, Brian Ga Dalton, Ziad T Awad
BACKGROUND: Recent data suggest that surgical outcomes at hospitals caring for low-income, vulnerable populations are suboptimal compared to non safety net hospitals. Therefore, the purpose of our study was to compare outcomes for patients who underwent an Ivor-Lewis esophagectomy at a safety net hospital with the National Surgical Quality Improvement Program (NSQIP) database. STUDY DESIGN: We retrospectively reviewed the medical records of consecutive patients who underwent an Ivor-Lewis esophagectomy from September 2013 to January 2017 at a single safety net hospital...
January 21, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29470830/strong-enhancement-by-igf1-r-antagonists-of-hepatocellular-carcinoma-cell-migration-inhibition-by-sorafenib-and-or-vitamin-k1
#8
Rosalba D'Alessandro, Maria Grazia Refolo, Catia Lippolis, Nicola Carella, Caterina Messa, Aldo Cavallini, Brian Irving Carr
PURPOSE: Emerging evidence indicates that combining Sorafenib with vitamin K1 (VK1) may result in a synergistic inhibition of hepatocellular carcinoma (HCC) cell migration and proliferation. Despite this synergy, its benefits may be limited due to drug resistance resulting from cross-talk with the tumor microenvironment. Insulin-like growth factor-1 (IGF1) signaling acts as an important modulator of HCC cell growth, motility and drug resistance. Therefore, we aimed to explore the effects of Sorafenib in combination with VK1 and/or IGF1-R antagonists on HCC cells...
February 22, 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29470681/a-large-scale-multiomics-analysis-of-wheat-stem-solidness-and-the-wheat-stem-sawfly-feeding-response-and-syntenic-associations-in-barley-brachypodium-and-rice
#9
Sezgi Biyiklioglu, Burcu Alptekin, B Ani Akpinar, Andrea C Varella, Megan L Hofland, David K Weaver, Brian Bothner, Hikmet Budak
The wheat stem sawfly (WSS), Cephus cinctus Norton (Hymenoptera: Cephidae), is an important pest of wheat and other cereals, threatening the quality and quantity of grain production. WSS larvae feed and develop inside the stem where they are protected from the external environment; therefore, pest management strategies primarily rely on host plant resistance. A major locus on the long arm of wheat chromosome 3B underlies most of the variation in stem solidness; however, the impact of stem solidness on WSS feeding has not been completely characterized...
February 22, 2018: Functional & Integrative Genomics
https://www.readbyqxmd.com/read/29470661/granulomatous-lymphocytic-interstitial-lung-disease-in-22q11-2-deletion-syndrome-a-case-report-and-literature-review
#10
REVIEW
Amika K Sood, William Funkhouser, Brian Handly, Brent Weston, Eveline Y Wu
PURPOSE OF REVIEW: Granulomatous-lymphocytic interstitial lung disease (GLILD) has classically been associated with common variable immune deficiency (CVID), but is increasingly being reported in other immunodeficiencies. We describe the second reported case of GLILD in a patient with 22q11.2 deletion syndrome (22q11.2DS) and review the recent literature surrounding GLILD. RECENT FINDINGS: GLILD is characterized by granulomata and lymphoproliferation. Consensus statements and retrospective and case-control studies have better elucidated the clinicopathological and radiographic manifestations of GLILD, allowing for its differentiation from similar conditions like sarcoidosis...
February 22, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29470364/resistance-training-is-associated-with-higher-bone-mineral-density-among-young-adult-male-distance-runners-independent-of-physiological-factors
#11
Anthony A Duplanty, Danielle E Levitt, David W Hill, Brian K McFarlin, Nancy M DiMarco, Jakob L Vingren
Low bone mineral density (BMD) in male distance runners is common and could be modulated by a host of biomarkers involved in the dynamic balance of bone tissue. In contrast, resistance training can increase BMD; however, the efficacy of resistance training in protecting BMD in distance runners has not been elucidated. OBJECTIVE: To investigate the relationship between resistance training, testosterone and bone metabolism biomarker concentrations, and BMD in young adult male distance runners...
February 20, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29470330/in-reply
#12
Justin R Lappen, Norman Bolden, Brian M Mercer, Edward K S Chien
No abstract text is available yet for this article.
March 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29470326/national-partnership-for-maternal-safety-consensus-bundle-on-safe-reduction-of-primary-cesarean-births-supporting-intended-vaginal-births
#13
David C Lagrew, Lisa Kane Low, Rita Brennan, Maureen P Corry, Joyce K Edmonds, Brian G Gilpin, Jennifer Frost, Whitney Pinger, Dale P Reisner, Sara Jaffer
Cesarean births and associated morbidity and mortality have reached near epidemic proportions. The National Partnership for Maternal Safety under the guidance of the Council on Patient Safety in Women's Health Care responded by developing a patient safety bundle to reduce the number of primary cesarean births. Safety bundles outline critical practices to implement in every maternity unit. This National Partnership for Maternity Safety bundle, as with other bundles, is organized into four domains: Readiness, Recognition and Prevention, Response, and Reporting and Systems Learning...
March 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29470279/acute-serum-cartilage-biomarker-response-following-walking-and-drop-landing
#14
Matthew S Harkey, J Troy Blackburn, Anthony C Hackney, Michael D Lewek, Randy J Schmitz, Brian Pietrosimone
INTRODUCTION: An in depth understanding of the healthy cartilage response to activities of daily living is needed to better understand the complex relationship between cartilage health and loading. The purpose was to assess the role of loading on the acute serum cartilage oligomeric matrix protein (COMP) response in recreationally active individuals. METHODS: 40 individuals without previous lower extremity injury participated in this repeated measures study in which each participant completed all conditions during independent data collection sessions separated by at least one week...
February 21, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29470085/origins-of-the-endo-and-exo-selectivities-in-cyclopropenone-iminocyclopropene-and-triafulvene-diels-alder-cycloadditions
#15
Brian J Levandowski, Trevor A Hamlin, Roger C Helgeson, F Matthias Bickelhaupt, Kendall N Houk
The endo and exo stereoselectivities of Diels-Alder reactions of cyclopropenone, iminocyclopropene, and substituted triafulvenes with butadiene were rationalized using density functional theory calculations. When cyclopropenone is the dienophile there is a 1.8 kcal/mol preference for the exo cycloaddition with butadiene. While the reaction of 3-difluoromethylene triafulvene with butadiene favors the endo cycloaddition by 2.8 kcal/mol. The influence of charge transfer and secondary orbital interactions on the stereoselectivity of Diels-Alder reactions involving triafulvenes and heteroanalogs is discussed...
February 22, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29469981/moisture-availability-limits-subalpine-tree-establishment
#16
Robert A Andrus, Brian J Harvey, Kyle C Rodman, Sarah J Hart, Thomas T Veblen
In the absence of broad-scale disturbance, many temperate coniferous forests experience successful seedling establishment only when abundant seed production coincides with favorable climate. Identifying the frequency of past establishment events and the climate conditions favorable for seedling establishment is essential to understanding how climate warming could affect the frequency of future tree establishment events and therefore future forest composition or even persistence of a forest cover. In the southern Rocky Mountains, USA, research on the sensitivity of establishment of Engelmann spruce (Picea engelmannii) and subalpine fir (Abies lasiocarpa)-two widely distributed, co-occurring conifers in North America-to climate variability has focused on the alpine treeline ecotone, leaving uncertainty about the sensitivity of these species across much of their elevation distribution...
February 22, 2018: Ecology
https://www.readbyqxmd.com/read/29469748/mycobacterium-marinum-infection-contracted-from-seaweed-wrap-in-a-psoriasis-patient-undergoing-treatment-with-adalimumab
#17
Irene Timoney, Maeve Lynch, Leonard Timoney, Eoin Feeney, Brian Kirby
We report a patient with psoriasis who developed Mycobacterium marinum (M. marinum) infection after seven years of treatment with adalimumab, a human anti-TNF (tumor necrosis factor) monoclonal antibody. TNF is a pro-inflammatory cytokine that plays a central role in the pathogenesis of psoriasis and a number of other immune-mediated inflammatory diseases. TNF plays an important role in granuloma formation and host defense against mycobacterial infections. Several cases of atypical mycobacterial infections in patients on TNF inhibitors have been reported...
August 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469198/dose-escalation-is-needed-for-gross-disease-in-high-risk-neuroblastoma
#18
Dana L Casey, Brian H Kushner, Nai-Kong V Cheung, Shakeel Modak, Michael P LaQuaglia, Suzanne L Wolden
BACKGROUND: Locoregional failure is common after subtotal resection in high-risk neuroblastoma. Although a dose of 21 Gy radiation therapy (RT) is standard for treatment of high-risk neuroblastoma after gross total resection, the dose needed for local control of patients with gross residual disease at the time of RT is unknown. We sought to evaluate local control after 21-36 Gy RT in patients with high-risk neuroblastoma undergoing subtotal resection. METHODS: All patients with high-risk neuroblastoma who received RT to their primary site from 2000 to 2016 were reviewed...
February 22, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29469046/treatment-of-type-1-hepatorenal-syndrome-with-pentoxifylline-a-randomized-placebo-controlled-clinical-trial
#19
Jonathan G Stine, Jennifer Wang, Scott L Cornella, Brian W Behm, Zachary Henry, Neeral L Shah, Stephen H Caldwell, Patrick G Northup
INTRODUCTION: Type-1 hepatorenal syndrome (HRS-1) portends a poor prognosis in patients with cirrhosis. Currently available medical therapies are largely ineffective, save for liver transplantation. We aimed to determine if pentoxifylline (PTX) therapy in addition to the standard of care of volume expansion with albumin and vasoconstriction with midodrine and octreotide (AMO) is safe and efficacious compared to AMO in HRS-1 treatment. MATERIAL AND METHODS: Hospitalized subjects with decompensated cirrhosis and HRS-1 were enrolled...
March 1, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29468951/cost-effectiveness-thresholds-methods-for-setting-and-examples-from-around-the-world
#20
André Soares Santos, Augusto Afonso Guerra-Junior, Brian Godman, Alec Morton, Cristina Mariano Ruas
INTRODUCTION: Cost-effectiveness thresholds (CETs) are used to judge if an intervention represents sufficient value for money to merit adoption in healthcare systems. The study was motivated by the Brazilian context of HTA, where meetings are being conducted to decide on the definition of a threshold. AREAS COVERED: An electronic search was conducted on Medline (via PubMed), Lilacs (via BVS) and ScienceDirect followed by a complementary search of references of included studies, Google Scholar and conference abstracts...
February 22, 2018: Expert Review of Pharmacoeconomics & Outcomes Research
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