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https://www.readbyqxmd.com/read/28449076/qtl-analysis-of-the-developmental-response-to-l-glutamate-in-arabidopsis-roots-and-its-genotype-by-environment-interactions
#1
Pia Walch-Liu, Rhonda C Meyer, Thomas Altmann, Brian G Forde
Primary root growth in Arabidopsis and a number of other species has previously been shown to be remarkably sensitive to the presence of external glutamate, with glutamate signalling eliciting major changes in root architecture. Using two recombinant inbred lines from reciprocal crosses between Arabidopsis accessions C24 and Col-0, we have identified one large-effect quantitative trait locus (QTL), GluS1, and two minor QTLs, GluS2 and GluS3, which together accounted for 41% of the phenotypic variance in glutamate sensitivity...
April 26, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28448769/dental-therapists-a-solution-to-a-shortage-of-dentists-in-underserved-communities
#2
Y Tony Yang, Brian Chen, Tanya Wanchek
No abstract text is available yet for this article.
May 2017: Public Health Reports
https://www.readbyqxmd.com/read/28448721/triplicate-sputum-cultures-for-efficacy-evaluation-of-novel-anti-tuberculosis-regimens
#3
Andreas H Diacon, Elana van Brakel, Nacer Lounis, Paul Meyvisch, Ben Van Baelen, Tine De Marez, Eilidh Jenkins, Brian Dannemann
No abstract text is available yet for this article.
April 27, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28448492/stylized-facts-of-intraday-precious-metals
#4
Jonathan Batten, Brian Lucey, Frank McGroarty, Maurice Peat, Andrew Urquhart
This paper examines the stylized facts, correlation and interaction between volatility and returns at the 5-minute frequency for gold, silver, platinum and palladium from May 2000 to April 2015. We study the full sample period, as well as three subsamples to determine how high-frequency data of precious metals have developed over time. We find that over the full sample, the number of trades has increased substantially over time for each precious metal, while the bid-ask spread has narrowed over time, indicating an increase in liquidity and price efficiency...
2017: PloS One
https://www.readbyqxmd.com/read/28448320/difficult-airway-management-resulting-from-local-anesthetic-allergy-during-emergent-cesarean-delivery-a-case-report
#5
Courtney L Maxey-Jones, Alec Palmerton, Jocelyn R Farmer, Brian T Bateman
Difficult airway management in the gravid patient is a well-described phenomenon. We present a case of emergent cesarean delivery complicated by a "cannot intubate, cannot ventilate" scenario that was later determined to be secondary to an allergic, IgE-mediated reaction to epidurally administered local anesthetic.
April 26, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28448273/magnetic-induction-spectroscopy-mis-probe-design-for-cervical-tissue-measurements
#6
Jau-Yi Wang, Timothy Healey, Anthony Barker, Brian Brown, Chris Monk, Dilly Anumba
OBJECTIVE: Gradiometers have the advantage of increasing measuring sensitivity, which is particularly useful in magnetic induction spectroscopy (MIS) for bio-impedance measurements. Traditional gradiometers use a pair of field sensing coils equally distant and on opposite sides of a drive coil, which provides high immunity to interference. In this paper, a ferrite-cored coaxial gradiometer probe of 29 mm diameter has been developed for measuring the impedance spectra of cervical tissues in vivo...
April 27, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28448197/surgical-site-infections-and-associated-operative-characteristics
#7
Paul K Waltz, Brian S Zuckerbraun
Surgical site infection (SSI) contributes significantly to surgical morbidity. Patient factors and operative factors contribute to the risk of development of SSI. This review focuses on understanding operative characteristics that are associated with an increased risk of SSI. Much attention has been given to protocol care to reduce SSI, such as hair removal, skin preparation, and pre-operative antibiotic agents. Even with this, the appropriate antibiotic and re-dosing regimens often remain a challenge. Other operative factors such as blood loss/transfusion, emergency/urgent cases, duration of the operation, type of anesthesia, and resident involvement are also potentially modifiable to reduce the risk of SSI...
April 27, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28448154/improving-lithium-sulfur-battery-performance-under-lean-electrolyte-through-nanoscale-confinement-in-soft-swellable-gels
#8
Junzheng Chen, Wesley A Henderson, Huilin Pan, Brian R Perdue, Ruiguo Cao, Jian Zhi Hu, Chuan Wan, Kee Sung Han, Karl T Mueller, Ji-Guang Zhang, Yuyan Shao, Jun Liu
Li-S batteries have been extensively studied using rigid carbon as the host for sulfur encapsulation, but improving the properties with a reduced electrolyte amount remains a significant challenge. This is critical for achieving high energy density. Here, we developed a soft PEO10LiTFSI polymer swellable gel as a nanoscale reservoir to trap the polysulfides under lean electrolyte conditions. The PEO10LiTFSI gel immobilizes the electrolyte and confines polysulfides within the ion conducting phase. The Li-S cell with a much lower electrolyte to sulfur ratio (E/S) of 4 gE/gS (3...
April 27, 2017: Nano Letters
https://www.readbyqxmd.com/read/28448072/evaluation-of-ptgs2-expression-pik3ca-mutation-aspirin-use-and-colon-cancer-survival-in-a-population-based-cohort-study
#9
Ronan T Gray, Marie M Cantwell, Helen G Coleman, Maurice B Loughrey, Peter Bankhead, Stephen McQuaid, Roisin F O'Neill, Kenneth Arthur, Victoria Bingham, Claire McGready, Anna T Gavin, Chris R Cardwell, Brian T Johnston, Jacqueline A James, Peter W Hamilton, Manuel Salto-Tellez, Liam J Murray
OBJECTIVES: The association between aspirin use and improved survival after colorectal cancer diagnosis may be more pronounced in tumors that have PIK3CA mutations or high PTGS2 expression. However, the evidence of a difference in association by biomarker status lacks consistency. In this population-based colon cancer cohort study the interaction between these biomarkers, aspirin use, and survival was assessed. METHODS: The cohort consisted of 740 stage II and III colon cancer patients diagnosed between 2004 and 2008...
April 27, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28448069/systems-biology-guided-by-xcms-online-metabolomics
#10
Tao Huan, Erica M Forsberg, Duane Rinehart, Caroline H Johnson, Julijana Ivanisevic, H Paul Benton, Mingliang Fang, Aries Aisporna, Brian Hilmers, Farris L Poole, Michael P Thorgersen, Michael W W Adams, Gregory Krantz, Matthew W Fields, Paul D Robbins, Laura J Niedernhofer, Trey Ideker, Erica L Majumder, Judy D Wall, Nicholas J W Rattray, Royston Goodacre, Luke L Lairson, Gary Siuzdak
No abstract text is available yet for this article.
April 27, 2017: Nature Methods
https://www.readbyqxmd.com/read/28447935/host-selected-mutations-converging-on-a-global-regulator-drive-an-adaptive-leap-by-bacteria-to-symbiosis
#11
Molly Sabrina Pankey, Randi L Foxall, Ian M Ster, Lauren A Perry, Brian M Schuster, Rachel A Donner, Matthew Coyle, Vaughn S Cooper, Cheryl A Whistler
Host immune and physical barriers protect against pathogens but also impede the establishment of essential symbiotic partnerships. To reveal mechanisms by which beneficial organisms adapt to circumvent host defenses, we experimentally evolved ecologically distinct bioluminescent Vibrio fischeri through Euprymna scolopes squid light organs. Serial squid passaging of bacteria produced eight distinct mutations in the binK sensor kinase gene that conferred an exceptional selective advantage demonstrated through both empirical and theoretical analysis...
April 27, 2017: ELife
https://www.readbyqxmd.com/read/28447855/the-arterial-anatomy-of-the-deltoid-ligament-a-cadaveric-study
#12
Jacob A Haynes, Michelle Gosselin, Brian Cusworth, Jeremy McCormick, Jeffery Johnson, Sandra Klein
BACKGROUND: There is an increasing interest in the operative treatment of deltoid ligament disruption in the setting of chronic ankle instability. Understanding the vascular anatomy of the deltoid complex is beneficial when considering operative procedures on the medial ankle and may provide insight into factors that lead to chronic deltoid insufficiency and ankle instability. METHODS: Thirty-two pairs of cadaveric specimens (64 total legs) were amputated below the knee, and the tibialis anterior, tibialis posterior, and peroneal arteries were injected with India ink and Ward's blue latex...
April 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28447674/role-of-grain-size-on-redox-induced-compositional-stresses-in-pr-doped-ceria-thin-films
#13
Jay Sheth, Di Chen, Harry L Tuller, Scott T Misture, Sean R Bishop, Brian W Sheldon
In constrained geometries and in varying oxygen partial pressures and operating temperatures, exchange of oxygen ions between non-stoichiometric oxide thin films (for example, doped and undoped ceria systems) and the gas phase can lead to stresses. In this study, these compositional stresses were investigated in thin films of nanocrystalline 10% praseodymium doped ceria (PCO), as a function of average grain size. In situ wafer curvature measurements, along with High Temperature X-Ray Diffraction (HTXRD), were employed to measure stresses and strains, respectively on the PCO films during oxidation-reduction cycling, over the pO2 range of 10(-1)-10(-5) atm at 750 °C...
April 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28447668/functional-characterization-of-a-multi-cancer-risk-locus-on-chr5p15-33-reveals-regulation-of-tert-by-znf148
#14
Jun Fang, Jinping Jia, Matthew Makowski, Mai Xu, Zhaoming Wang, Tongwu Zhang, Jason W Hoskins, Jiyeon Choi, Younghun Han, Mingfeng Zhang, Janelle Thomas, Michael Kovacs, Irene Collins, Marta Dzyadyk, Abbey Thompson, Maura O'Neill, Sudipto Das, Qi Lan, Roelof Koster, Rachael S Stolzenberg-Solomon, Peter Kraft, Brian M Wolpin, Pascal W T C Jansen, Sara Olson, Katherine A McGlynn, Peter A Kanetsky, Nilanjan Chatterjee, Jennifer H Barrett, Alison M Dunning, John C Taylor, Julia A Newton-Bishop, D Timothy Bishop, Thorkell Andresson, Gloria M Petersen, Christopher I Amos, Mark M Iles, Katherine L Nathanson, Maria Teresa Landi, Michiel Vermeulen, Kevin M Brown, Laufey T Amundadottir
Genome wide association studies (GWAS) have mapped multiple independent cancer susceptibility loci to chr5p15.33. Here, we show that fine-mapping of pancreatic and testicular cancer GWAS within one of these loci (Region 2 in CLPTM1L) focuses the signal to nine highly correlated SNPs. Of these, rs36115365-C associated with increased pancreatic and testicular but decreased lung cancer and melanoma risk, and exhibited preferred protein-binding and enhanced regulatory activity. Transcriptional gene silencing of this regulatory element repressed TERT expression in an allele-specific manner...
May 2, 2017: Nature Communications
https://www.readbyqxmd.com/read/28447624/wireless-power-transfer-to-millimeter-sized-gastrointestinal-electronics-validated-in-a-swine-model
#15
Abubakar Abid, Jonathan M O'Brien, Taylor Bensel, Cody Cleveland, Lucas Booth, Brian R Smith, Robert Langer, Giovanni Traverso
Electronic devices placed in the gastrointestinal (GI) tract for prolonged periods have the potential to transform clinical evaluation and treatment. One challenge to the deployment of such gastroresident electronics is the difficulty in powering millimeter-sized electronics devices without using batteries, which compromise biocompatibility and long-term residence. We examined the feasibility of leveraging mid-field wireless powering to transfer power from outside of the body to electronics at various locations along the GI tract...
April 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28447279/multi-modality-molecular-imaging-of-aortic-aneurysms
#16
Brian J Malm, Mehran M Sadeghi
Aneurysms of the thoracic and abdominal aorta are common and can be associated with significant morbidity and mortality when complications, including dissection, rupture, or thrombosis, occur. Current approaches to diagnosis and risk stratification rely on measurements of aneurysm size and rate of growth, often using various imaging modalities, which may be suboptimal in identifying patients at the highest and lowest risk of complications. Targeting the biological processes underlying aneurysm formation and expansion with molecular imaging offers an exciting opportunity to characterize aortic aneurysms beyond size and address current gaps in our approach to diagnosis and treatment...
April 26, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28447126/erratum-to-comparative-lung-bioavailability-of-fluticasone-salmeterol-via-a-breath-actuated-spacer-and-conventional-plastic-spacers
#17
Arun Nair, Lorna McKinlay, Peter Williamson, Philip Short, Patricia Burns, Brian J Lipworth
No abstract text is available yet for this article.
April 26, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28446995/marginalized-mixture-models-for-count-data-from-multiple-source-populations
#18
Habtamu K Benecha, Brian Neelon, Kimon Divaris, John S Preisser
Mixture distributions provide flexibility in modeling data collected from populations having unexplained heterogeneity. While interpretations of regression parameters from traditional finite mixture models are specific to unobserved subpopulations or latent classes, investigators are often interested in making inferences about the marginal mean of a count variable in the overall population. Recently, marginal mean regression modeling procedures for zero-inflated count outcomes have been introduced within the framework of maximum likelihood estimation of zero-inflated Poisson and negative binomial regression models...
2017: Journal of Statistical Distributions and Applications
https://www.readbyqxmd.com/read/28446924/differential-leukocyte-counting-via-fluorescent-detection-and-image-processing-on-a-centrifugal-microfluidic-platform
#19
Max L Balter, Alvin I Chen, C Amara Colinco, Alexander Gorshkov, Brian Bixon, Vincent Martin, Alexander Fromholtz, Timothy J Maguire, Martin L Yarmush
Centrifugal microfluidics has received much attention in the last decade for the automation of blood testing at the point-of-care, specifically for the detection of chemistries, proteins, and nucleic acids. However, the detection of common blood cells on-disc, particularly leukocytes, remains a challenge. In this paper, we present two analytical methods for enumerating leukocytes on a centrifugal platform using a custom-built fluorescent microscope, acridine orange nuclear staining, and image processing techniques...
December 21, 2016: Analytical Methods: Advancing Methods and Applications
https://www.readbyqxmd.com/read/28446890/partial-visual-loss-affects-self-reports-of-hearing-abilities-measured-using-a-modified-version-of-the-speech-spatial-and-qualities-of-hearing-questionnaire
#20
Andrew J Kolarik, Rajiv Raman, Brian C J Moore, Silvia Cirstea, Sarika Gopalakrishnan, Shahina Pardhan
We assessed how visually impaired (VI) people perceived their own auditory abilities using an established hearing questionnaire, the Speech, Spatial, and Qualities of Hearing Scale (SSQ), that was adapted to make it relevant and applicable to VI individuals by removing references to visual aspects while retaining the meaning of the original questions. The resulting questionnaire, the SSQvi, assessed perceived hearing ability in diverse situations including the ability to follow conversations with multiple speakers, assessing how far away a vehicle is, and the ability to perceptually segregate simultaneous sounds...
2017: Frontiers in Psychology
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