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https://www.readbyqxmd.com/read/29666966/point-of-care-lung-ultrasound-for-diagnosis-of-pneumocystis-jirovecii-pneumonia-notes-from-the-field
#1
Maria Teresa Giordani, Francesca Tamarozzi, Daniel Kaminstein, Enrico Brunetti, Tom Heller
BACKGROUND: Thoracic ultrasound is helpful to evaluate lung pathology in patients with acute dyspnea. Several studies have demonstrated the efficacy of point-of-care ultrasound in patients with extrapulmonary TB and HIV co-infection. This retrospective, open-label case-control study explores the role of lung ultrasound in the diagnosis of Pneumocystis jirovecii pneumonia (PJP) in HIV-positive patients. In particular, it highlights the potential role of specific sonographic features that may be unique to this population...
April 17, 2018: Critical Ultrasound Journal
https://www.readbyqxmd.com/read/29663875/heterocyclic-n-oxides-a-promising-class-of-agents-against-tuberculosis-malaria-and-neglected-tropical-diseases
#2
Guilherme Felipe Dos Santos Fernandes, Aline Renata Pavan, Jean Leandro Dos Santos
Heterocyclic N-oxides have emerged as promising agents against a number of diseases and disorders, especially infectious diseases. This review analyzes the emergence and development of this scaffold in the medicinal chemistry, focusing mainly on the discovery of new heterocyclic N-oxide compounds with potent activity against tuberculosis, malaria and neglected tropical diseases (i.e. leishmaniasis and Chagas disease). A number of heterocyclic N-oxide are described herein, nevertheless, the following chemical classes deserve to be highlighted due to the large number of reports in the literature about their promising pharmacological effects: furoxan, benzofuroxan, quinoxaline 1,4-di-N-oxide, indolone N-oxide and benzimidazole N-oxide...
April 17, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29657002/clinical-management-of-canine-leishmaniosis-versus-human-leishmaniasis-due-to-leishmania-infantum-putting-one-health-principles-into-practice
#3
Guadalupe Miró, Rogelio López-Vélez
The initiative One World, "One Health" tries to rapidly detect emerging or reemerging human and animal infectious diseases and prevent epidemiological situations such as deforestation, some agricultural practices or the appearance of new foci of leishmaniosis due to Leishmania infantum with alternative reservoirs. With this objective in mind, we here consider leishmaniosis in the Mediterranean basin and compare its current clinical management from two perspectives: that of a veterinarian specialized in infectious and parasitic diseases, and that of a physician specialized in infectious tropical diseases...
April 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29649602/point-of-care-and-point-of-can-leveraging-reference-laboratory-capacity-for-integrated-diagnosis-of-fever-syndromes-in-the-tropics
#4
REVIEW
Makeda Semret, Momar Ndao, Jan Jacobs, Cedric P Yansouni
BACKGROUND: There is an urgent need for integrated diagnosis of febrile syndromes, able to account for multiple pathogens and inform decisions for clinical care and public health. AIMS: To reflect on the evolving roles of laboratory-based testing for non-malarial febrile illnesses (NMFI) in low-resource settings (LRS), and to consider how advances in diagnostics, in connectivity and transport, and in quality-systems implementation may substantially enhance the capacity of reference laboratories to bridge the current gap between remote passive surveillance and clinically meaningful integrated fever diagnosis...
April 9, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29649073/safety-of-targeted-prophylaxis-strategy-in-patients-with-resolved-hepatitis-b-virus-infection-receiving-rituximab-for-immune-mediated-diseases
#5
Michele Spinicci, Giacomo Emmi, Laura Dies, Alessandro Barilaro, Gianfranco Vitiello, Jessica Mencarini, Annalisa Cavallo, Alessandro Bartoloni, Filippo Bartalesi
OBJECTIVES: Rituximab (RTX) is a monoclonal antibody that is widely used in hematologic malignancies and immune-mediated diseases (IMID) and has been associated with the risk of hepatitis B virus reactivation (HBVr). Thus, antiviral prophylaxis is recommended before RTX treatment in all patients with chronic hepatitis B virus (HBV) infection and those with resolved infection affected by onco-hematological conditions. By contrast, the correct management of HBsAg-negative/HbcAb-positive patients candidates for RTX-containing regimens for IMID is still debated, owing to few data currently available in this setting...
April 11, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29644966/diagnosis-and-treatment-of-neurocysticercosis-2017-clinical-practice-guidelines-by-the-infectious-diseases-society-of-america-idsa-and-the-american-society-of-tropical-medicine-and-hygiene-astmh
#6
A Clinton White, Christina M Coyle, Vedantam Rajshekhar, Gagandeep Singh, W Allen Hauser, Aaron Mohanty, Hector H Garcia, Theodore E Nash
No abstract text is available yet for this article.
April 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29627510/occurrence-of-clostridium-difficile-infections-in-serbia-and-high-proportion-of-pcr-ribotype-027-strains-in-two-hospitals-in-belgrade
#7
Milica Jovanović, Tanja Tošić, Mitra Drakulović, Rajica Stošović, Snežana Jovanović
BACKGROUND: The incidence of Clostridium difficile infections (CDI) in the Clinical Center of Serbia (CCS) and the entire Serbia has been constantly rising in the previous 5 years. We aimed to study C. difficile PCR-ribotypes isolated from patients hospitalized at two healthcare institutions: CCS and Specialized Hospital for Cerebrovascular Diseases "Sveti Sava" (SS), both of them from Belgrade, and to investigate the incidence rates of CDI in hospital settings in Serbia, from 2009 to 2013...
April 5, 2018: Anaerobe
https://www.readbyqxmd.com/read/29619441/a-new-copper-ii-imidazole-derivative-effectively-inhibits-replication-of-denv-2-in-vero-cell
#8
Teguh Hari Sucipto, Siti Churrotin, Harsasi Setyawati, Fahimah Martak, Kris Cahyo Mulyatno, Ilham Harlan Amarullah, Tomohiro Kotaki, Masanori Kameoka, Subagyo Yotopranoto, And Soegeng Soegijanto
Background: Dengue is a kind of infectious disease that was distributed in the tropical and sub-tropical areas. To date, there is no clinically approved dengue vaccine or antiviral for humans, even though there have been great efforts towards this end. Therefore, finding the effective compound against dengue virus (DENV) replication is very important. Among the complex compounds, copper(II)-imidazole derivatives are of interest because of their biological and medicinal benefits. Materials and Methods: In the present study, antiviral activity of [Cu(2,4,5-triphenylimidazole)2 ]n , was evaluated against different stages of dengue virus type 2 (DENV-2) replication in Vero cell using focus forming unit reduction assay and quantitative ELISA...
2018: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29619364/harnessing-big-data-for-communicable-tropical-and-sub-tropical-disorders-implications-from-a-systematic-review-of-the-literature
#9
Vincenza Gianfredi, Nicola Luigi Bragazzi, Daniele Nucci, Mariano Martini, Roberto Rosselli, Liliana Minelli, Massimo Moretti
Aim: According to the World Health Organization (WHO), communicable tropical and sub-tropical diseases occur solely, or mainly in the tropics, thriving in hot, and humid conditions. Some of these disorders termed as neglected tropical diseases are particularly overlooked. Communicable tropical/sub-tropical diseases represent a diverse group of communicable disorders occurring in 149 countries, favored by tropical and sub-tropical conditions, affecting more than one billion people and imposing a dramatic societal and economic burden...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29617787/diagnosis-and-treatment-of-neurocysticercosis-2017-clinical-practice-guidelines-by-the-infectious-diseases-society-of-america-idsa-and-the-american-society-of-tropical-medicine-and-hygiene-astmh
#10
A Clinton White, Christina M Coyle, Vedantam Rajshekhar, Gagandeep Singh, W Allen Hauser, Aaron Mohanty, Hector H Garcia, Theodore E Nash
No abstract text is available yet for this article.
April 3, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29615623/biogeography-of-leptospira-in-wild-animal-communities-inhabiting-the-insular-ecosystem-of-the-western-indian-ocean-islands-and-neighboring-africa
#11
Muriel Dietrich, Yann Gomard, Erwan Lagadec, Beza Ramasindrazana, Gildas Le Minter, Vanina Guernier, Aude Benlali, Gerard Rocamora, Wanda Markotter, Steven M Goodman, Koussay Dellagi, Pablo Tortosa
Understanding the processes driving parasite assemblages is particularly important in the context of zoonotic infectious diseases. Leptospirosis is a widespread zoonotic bacterial infection caused by pathogenic species of the genus Leptospira. Despite a wide range of animal hosts, information is still lacking on the factors shaping Leptospira diversity in wild animal communities, especially in regions, such as tropical insular ecosystems, with high host species richness and complex biogeographical patterns...
April 4, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29609605/severe-plasmodium-ovale-malaria-complicated-by-acute-respiratory-distress-syndrome-in-a-young-caucasian-man
#12
Alessandra D'Abramo, Saba Gebremeskel Tekle, Marco Iannetta, Laura Scorzolini, Alessandra Oliva, Maria Grazia Paglia, Angela Corpolongo, Emanuele Nicastri
BACKGROUND: Although Plasmodium ovale is considered the cause of only mild malaria, a case of severe malaria due to P. ovale with acute respiratory distress syndrome is reported. CASE PRESENTATION: A 37-year old Caucasian man returning home from Angola was admitted for ovale malaria to the National Institute for Infectious Diseases Lazzaro Spallanzani in Rome, Italy. Two days after initiation of oral chloroquine treatment, an acute respiratory distress syndrome was diagnosed through chest X-ray and chest CT scan with intravenous contrast...
April 2, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29606107/plasmodium-knowlesi-infection-in-a-returning-german-traveller-from-thailand-a-case-report-on-an-emerging-malaria-pathogen-in-a-popular-low-risk-travel-destination
#13
Guenter Froeschl, Marcus Beissner, Kristina Huber, Gisela Bretzel, Michael Hoelscher, Camilla Rothe
BACKGROUND: Thailand is a major destination for German travellers with more than 760,000 arrivals in 2015. At the same time, malaria is a concern in travel recommendations with regard to this destination. The World Malaria Report of 2016 mentions only P. falciparum and P. vivax as prevalent species for Thailand, however, P. knowlesi infections have been occasionally reported in Thailand. In German travellers, only five cases of P. knowlesi infections have been reported to date. CASE PRESENTATION: A 45-year-old German male tourist travelled to Thailand from 25 December 2016 to 13 January 2017...
April 2, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29604267/serca-plays-a-crucial-role-in-the-toxicity-of-a-betulinic-acid-derivative-with-potential-antimalarial-activity
#14
Denise Diedrich, Andreia C Wildner, Thayse F Silveira, Gloria N S Silva, Francine Dos Santos, Vanessa Petry do Canto, Grace Gosmann, Ana Maria Bergold, Aline R Zimmer, Paulo A Netz, Simone C B Gnoatto
Malaria is one of the most significant infectious diseases that affect poor populations in tropical areas throughout the world. Plants have been shown to be a good source for the development of new antimalarial chemotherapeutic agents, as shown for the discovery of quinine and artemisinin derivatives. Our research group has been working with semisynthetic triterpene derivatives that show potential antimalarial activity toward different strains of Plasmodium falciparum by specifically modulating calcium pathways in the parasite...
March 28, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29602038/a-comprehensive-review-of-chalcone-derivatives-as-antileishmanial-agents
#15
REVIEW
Marcos Vinícius Palmeira de Mello, Barbara de Azevedo Abrahim-Vieira, Thaisa Francielle Souza Domingos, Jessica Barbosa de Jesus, Ana Carolina Corrêa de Sousa, Carlos Rangel Rodrigues, Alessandra M Teles de Souza
Leishmaniasis is a group of infectious neglected tropical diseases caused by more than 20 pathogenic species of Leishmania sp. Due to the limitations of the current treatments available, chalcone moiety has been drawn with a lot of attention due to the simple chemistry and synthesis, being reported with antileishmanial activity in particular against amastigote form. This review aims to provide an overview towards antileishmanial activity of chalcones derivatives against amastigote form for Leishmania major, L...
March 22, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29599242/shifts-in-disease-dynamics-in-a-tropical-amphibian-assemblage-are-not-due-to-pathogen-attenuation
#16
Jamie Voyles, Douglas C Woodhams, Veronica Saenz, Allison Q Byrne, Rachel Perez, Gabriela Rios-Sotelo, Mason J Ryan, Molly C Bletz, Florence Ann Sobell, Shawna McLetchie, Laura Reinert, Erica Bree Rosenblum, Louise A Rollins-Smith, Roberto Ibáñez, Julie M Ray, Edgardo J Griffith, Heidi Ross, Corinne L Richards-Zawacki
Infectious diseases rarely end in extinction. Yet the mechanisms that explain how epidemics subside are difficult to pinpoint. We investigated host-pathogen interactions after the emergence of a lethal fungal pathogen in a tropical amphibian assemblage. Some amphibian host species are recovering, but the pathogen is still present and is as pathogenic today as it was almost a decade ago. In addition, some species have defenses that are more effective now than they were before the epidemic. These results suggest that host recoveries are not caused by pathogen attenuation and may be due to shifts in host responses...
March 30, 2018: Science
https://www.readbyqxmd.com/read/29596281/chikungunya-in-a-pediatric-traveler
#17
Vanessa A Thomas, Kristy O Murray, Heather L Crouse
Chikungunya is a mosquito-transmitted virus found primarily in Africa and Asia. In late 2013, chikungunya virus emerged in the Western hemisphere, spreading from the Caribbean to South, Central, and North America (MMWR Morb Mortal Wkly Rep. 2014;63:1121-1128). Symptoms can be similar to nonspecific viral presentations including fever, joint pain, joint swelling, and rash. The diagnosis of infectious tropical diseases in the emergency department often requires a high index of suspicion, given the nonspecific early findings that characterize many of these tropical diseases...
March 28, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29594984/in-vivo-characterization-of-macrophage-tropic-simian-immunodeficiency-virus-molecular-clones-in-rhesus-macaques
#18
Sanjeev Gumber, Praveen Kumar Amancha, Po-Jen Yen, Francois Villinger, Dana Gabuzda, Siddappa N Byrareddy
Macrophages are a major target of HIV/SIV infection and play an important role in pathogenesis by serving as viral reservoirs in the central nervous system. Previously, a unique early SIVmac251 envelope (Env) variant, deSIV147 was cloned from blood of a rhesus macaque with rapid disease progression and SIV-associated encephalitis. Here, we show that infectious molecular clone deSIV147 caused systemic infection in rhesus macaques following intravenous or intrarectal exposure. Next, we inoculated deSIV147 into macaques depleted of CD4+ T cells and found that animals were SIV-positive, with high plasma and CSF viral loads...
March 28, 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/29578085/the-macroecology-of-cancer-incidences-in-humans-is-associated-with-large-scale-assemblages-of-endemic-infections
#19
Camille Jacqueline, Jessica L Abbate, Gabriele Sorci, Jean-François Guégan, Fréderic Thomas, Benjamin Roche
It is now well supported that 20% of human cancers have an infectious causation (i.e., oncogenic agents). Accumulating evidence suggests that aside from this direct role, other infectious agents may also indirectly affect cancer epidemiology through interactions with the oncogenic agents within the wider infection community. Here, we address this hypothesis via analysis of large-scale global data to identify associations between human cancer incidence and assemblages of neglected infectious agents. We focus on a gradient of three widely-distributed cancers with an infectious cause: bladder (~2% of recorded cancer cases are due to Shistosoma haematobium), liver (~60% consecutive to Hepatitis B and C infection) and stomach (Helicobacter pylori is associated with ~70% of cases)...
March 22, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29565981/malaria-diagnosis-by-pcr-revealed-differential-distribution-of-mono-and-mixed-species-infections-by-plasmodium-falciparum-and-p-vivax-in-india
#20
Nisha Siwal, Upasana Shyamsunder Singh, Manoswini Dash, Sonalika Kar, Swati Rani, Charu Rawal, Rajkumar Singh, Anupkumar R Anvikar, Veena Pande, Aparup Das
Malaria is a vector-borne infectious disease, caused by five different species of the genus Plasmodium, and is endemic to many tropical and sub-tropical countries of the globe. At present, malaria diagnosis at the primary health care level in India is conducted by either microscopy or rapid diagnostic test (RDT). In recent years, molecular diagnosis (by PCR assay), has emerged as the most sensitive method for malaria diagnosis. India is highly endemic to malaria and shoulders the burden of two major malaria parasites, Plasmodium falciparum and P...
2018: PloS One
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