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Tropical infectious diseases

Indri Hapsari Putri, Rahajeng N Tunjungputri, Philip G De Groot, Andre J van der Ven, Quirijn de Mast
Thrombocytopenia is a well-known manifestation of acute tropical infectious diseases. The role of platelets in infections has received much attention recently because of their emerging activities in modulation of inflammatory responses, host defense, and vascular integrity. However, while many studies have addressed thrombocytopenia in tropical infections, abnormalities in platelet function have been largely overlooked. This is an important research gap, as platelet dysfunction may contribute to the bleeding tendency that characterizes some tropical infections...
June 18, 2018: Seminars in Thrombosis and Hemostasis
Chaitawat Sa-Ngamuang, Peter Haddawy, Viravarn Luvira, Watcharapong Piyaphanee, Sopon Iamsirithaworn, Saranath Lawpoolsri
Differentiating dengue patients from other acute febrile illness patients is a great challenge among physicians. Several dengue diagnosis methods are recommended by WHO. The application of specific laboratory tests is still limited due to high cost, lack of equipment, and uncertain validity. Therefore, clinical diagnosis remains a common practice especially in resource limited settings. Bayesian networks have been shown to be a useful tool for diagnostic decision support. This study aimed to construct Bayesian network models using basic demographic, clinical, and laboratory profiles of acute febrile illness patients to diagnose dengue...
June 18, 2018: PLoS Neglected Tropical Diseases
Suporn Paksanont, Kitisak Sintiprungrat, Thatcha Yimthin, Pornpan Pumirat, Sharon J Peacock, Narisara Chantratita
Burkholderia pseudomallei is a flagellated, gram-negative environmental bacterium that causes melioidosis, a severe infectious disease of humans and animals in tropical areas. We hypothesised that B. pseudomallei may undergo phenotypic adaptation in response to an increase in growth temperature. We analysed the growth curves of B. pseudomallei strain 153 cultured in Luria-Bertani broth at five different temperatures (25 °C-42 °C) and compared the proteomes of bacteria cultured at 37 °C and 42 °C...
June 15, 2018: Scientific Reports
Sanjeeva Srivastava
This special issue focusing on proteomics-based investigations of neglected and tropical diseases has eight published articles of which five are research articles and three reviews and viewpoints articles. The idea of this special issue was originated in 14th Human Proteome Organization World Congress (HUPO 2015) in Vancouver during a discussion session of Human Infectious Diseases (HID) group meeting as part of HUPO's flagship project on Human Proteome Project (HPP). This session was well attended by the scientists working on infectious diseases as well as editor of Proteomics Clinical Applications, and constructive discussions led to the culmination of this special issue...
June 14, 2018: Proteomics. Clinical Applications
Farnaz Zahedifard, Sima Rafati
Leishmaniasis is one of the neglected tropical diseases and is highly endemic in many countries. Currently, there is no adequate human vaccine and treatment to control the disease. Areas covered: As a result of the failure of chemotherapy and toxicity, it is necessary to find another approach for the treatment of leishmaniasis. Recently, anti-microbial peptides (AMPs), originating from natural resources have attracted much attention for their use as a new antibiotics for many infectious and non-infectious diseases...
June 11, 2018: Expert Review of Anti-infective Therapy
Qing Yu, Hui Liu, Ning Xiao
Unmanned aerial vehicles (UAVs) have become useful tools to extend human abilities and capacities. Currently UAVs are being used for the surveillance of environmental factors related to the transmission of infectious diseases. They have also been used for delivering therapeutic drugs and life-saving supplies to patients or isolated persons in extreme conditions. There have been very few applications of UAVs for disease surveillance, control and prevention to date. However, we foresee many uses for these machines in the fight against zoonotic disease...
June 11, 2018: Infectious Diseases of Poverty
María Martínez-López, Manuel Soto, Salvador Iborra, David Sancho
Protozoan parasites of the Leishmania genus are the causative agents of leishmaniasis, a group of neglected tropical diseases whose clinical manifestations vary depending on the infectious Leishmania species but also on host factors. Recognition of the parasite by host myeloid immune cells is a key to trigger an effective Leishmania -specific immunity. However, the parasite is able to persist in host myeloid cells by evading, delaying and manipulating host immunity in order to escape host resistance and ensure its transmission...
2018: Frontiers in Microbiology
K Mehta, A Pajai, S Bhurke, A Shirkande, R Bhadade, R D'Souza
The epidemiological pattern of acute kidney injury (AKI) in tropical countries during monsoon reflects infectious disease as the most important cause. AKI is a confounding factor and may be overlooked by primary health-care providers and underreported in health statistics. The present study prospectively helps estimate the burden of disease and analyze etiology, clinical profile, and outcome in a tertiary care hospital of a metropolitan city in a tropical country. The study period included monsoon season of 2012 and 2013, a total of 8 months...
March 2018: Indian Journal of Nephrology
Tri Wangrangsimakul, Thomas Althaus, Mavuto Mukaka, Pacharee Kantipong, Vanaporn Wuthiekanun, Wirongrong Chierakul, Stuart D Blacksell, Nicholas P Day, Achara Laongnualpanich, Daniel H Paris
BACKGROUND: Tropical infectious diseases like dengue, scrub typhus, murine typhus, leptospirosis, and enteric fever continue to contribute substantially to the febrile disease burden throughout Southeast Asia while malaria is declining. Recently, there has been increasing focus on biomarkers (i.e. C-reactive protein (CRP) and procalcitonin) in delineating bacterial from viral infections. METHODOLOGY/PRINCIPAL FINDINGS: A prospective observational study was performed to investigate the causes of acute undifferentiated fever (AUF) in adults admitted to Chiangrai Prachanukroh hospital, northern Thailand, which included an evaluation of CRP and procalcitonin as diagnostic tools...
May 2018: PLoS Neglected Tropical Diseases
Phornpun Phokrai, Wisansanee Karoonboonyanan, Nida Thanapattarapairoj, Chidchanok Promkong, Adul Dulsuk, Sirikamon Koosakulnirand, Sasha Canovali, Nitaya Indrawattana, Yaowaruk Jutrakul, Vanaporn Wuthiekanun, Direk Limmathurotsakul, Paul J Brett, Mary N Burtnick, Ganjana Lertmemongkolchai, Narisara Chantratita
Melioidosis is a fatal infectious disease caused by the environmental bacterium Burkholderia pseudomallei It is highly endemic in Asia and northern Australia but neglected in many other tropical countries. Melioidosis patients have a wide range of clinical manifestations and definitive diagnosis requires bacterial culture which can be time-consuming. A reliable rapid serological tool is greatly needed for disease surveillance and diagnosis. We previously demonstrated by ELISA that a hemolysin-coregulated protein (Hcp1) is a promising target for serodiagnosis of melioidosis...
May 30, 2018: Journal of Clinical Microbiology
Hagen Frickmann, Ralf Matthias Hagen, Florian Geiselbrechtinger, Nagpal Hoysal
BACKGROUND: The European Union Training Mission Mali (EUTM MLI) is a multinational military training deployment to the Western African tropical nation of Mali. Based on routinely collected disease and non-battle injury surveillance data, this study quantifies the true impact of infectious diseases for this tropical mission and potential seasonal variations in infectious disease threats. METHODS: Categorized health events during the EUTM MLI mission and associated lost working days were reported using the EpiNATO-2 report...
May 31, 2018: Military Medical Research
Claudia Ohst, Sandra Saschenbrecker, Konstanze Stiba, Katja Steinhagen, Christian Probst, Christiane Radzimski, Erik Lattwein, Lars Komorowski, Winfried Stöcker, Wolfgang Schlumberger
Climate change, increased urbanization and international travel have facilitated the spread of mosquito vectors and the viral species they carry. Zika virus (ZIKV) is currently spreading in the Americas, while dengue virus (DENV) and chikungunya virus (CHIKV) have already become firmly established in most tropical and also many non-tropical regions. ZIKV, DENV and CHIKV overlap in their endemic areas and cause similar clinical symptoms, especially in the initial stages of infection. Infections with each of these viruses can lead to severe complications, and co-infections have been reported...
2018: Advances in Experimental Medicine and Biology
Sajad Rashidi, Kurosh Kalantar, Gholamreza Hatam
Visceral leishmaniasis (VL) is a tropical infectious disease, which is called Mediterranean visceral leishmaniasis (MVL) in the Mediterranean area. In spite of many attempts, no effective commercial vaccine exists for MVL. To find new targets for developing antileishmanial vaccines, knowing parasite antigens that provoke the immune system are on demand. Nowadays, proteomics methods are defined as approaches for analysis of protein profiling of different cells. Within this framework, detection of new antigens is becoming more facilitated...
June 2018: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
Diego Gomes da Rocha Voris, Luciana Dos Santos Dias, Josélia Alencar Lima, Keila Dos Santos Cople Lima, José Bento Pereira Lima, Antônio Luís Dos Santos Lima
Aedes aegypti is the vector responsible for transmitting pathogens that cause various infectious diseases, such as dengue, Zika, yellow fever, and chikungunya, worrying health authorities in the tropics. Due to resistance of mosquitoes to synthetic insecticides, the search for more effective insecticidal agents becomes crucial. The aim of this study was to verify the larvicidal, adulticidal, and anticholinesterase activities of the essential oils of the Illicium verum (EOIV), Pimenta dioica (EOPD), and Myristica fragrans (EOMF) against Ae...
May 28, 2018: Environmental Science and Pollution Research International
Gisele Sampaio Silva, Guy A Richards, Tim Baker, Jorge Hidalgo, Juan Ignacio Silesky Jiménez, Pravin Amin
Zika fever is an acute infectious disease caused by the Zika virus (ZIKV), an RNA virus belonging to the genus Flavivirus. ZIKV can be transmitted by bites from Aedes aegypti and Aedes albopictus species, sexual activity, blood transfusion and from mother to fetus during pregnancy and delivery. A total of 50 territories and countries in the Americas had reported ZIKV infections. For those with symptoms, the presentation is similar to dengue fever with body aches, joint pain, fatigue, malaise, fever and conjunctivitis lasting up to seven days...
April 5, 2018: Journal of Critical Care
Edwin Barrios, Sunmi Lee, Olga Vasilieva
There are many infectious diseases that can be spread by daily commuting of people and dengue fever is one of them. The absence of vaccine and irregularities in ongoing vector control programs make this disease the most frequent and persistent in many tropical and subtropical regions of the world. This paper targets to access the effects of daily commuting on dengue transmission dynamics by using a deterministic two-patch model fitted to observed data gathered in Cali, Colombia where dengue fever is highly persistent and exhibits endemo-epidemic patterns...
May 15, 2018: Journal of Theoretical Biology
Srinivasa Rao Mutheneni, Rajasekhar Mopuri, Suchithra Naish, Deepak Gunti, Suryanarayana Murty Upadhyayula
Background and objectives: Dengue is an emerging and re-emerging infectious disease, transmitted by mosquitoes. It is mostly prevalent in tropical and sub-tropical regions of the world, particularly, in Asia-Pacific region. To understand the epidemiology and spatial distribution of dengue, a retrospective surveillance study was conducted in the state of Andhra Pradesh, India during 2011-2013. Material and methods: District-wise disease endemicity levels were mapped through geographical information system (GIS) tools...
February 2018: Parasite Epidemiology and Control
Jorge Pérez-Ávila, Maria G Guzmán-Tirado, Jorge Fraga-Nodarse, Gray Handley, James Meegan, Jose L Pelegrino-Martínez de la Cotera, Anthony S Fauci
After December 17, 2014, when the US and Cuban governments announced their intent to restore relations, the two countries participated in various exchange activities in an effort to encourage cooperation in public health, health research and biomedical sciences. The conference entitled Exploring Opportunities for Arbovirus Research Collaboration, hosted at Havana's Hotel Nacional, was part of these efforts and was the first major US-Cuban scientific conference in over 50 years. Its purpose was to share information about current arbovirus research and recent findings, and to explore opportunities for future joint research...
April 2018: MEDICC Review
Alina González-Quevedo, Rosaralis Santiesteban-Freixas, Janis T Eells, Lucimey Lima, Alfredo A Sadun
From 1991 to 1993, an epidemic of optic and peripheral neuropathy-the largest of the century-broke out in Cuba, affecting more than 50,000 people. Initially the main clinical features were decreased visual acuity, central and cecocentral scotomas, impaired color vision and absence of the papillomacular bundle. Later, peripheral and mixed optic-peripheral forms began to appear. Due to the magnitude of the epidemic, the Cuban government requested help from the international community at the 46th World Health Assembly in 1993...
April 2018: MEDICC Review
Peechanika Pinweha, Pornpan Pumirat, Jon Cuccui, Niramol Jitprasutwit, Veerachat Muangsombut, Varintip Srinon, Usa Boonyuen, Parameth Thiennimitr, Paiboon Vattanaviboon, Felipe Cia, Sam Willcocks, Gregory J Bancroft, Brendan W Wren, Sunee Korbsrisate
Burkholderia pseudomallei, a gram-negative intracellular bacillus, is the causative agent of a tropical infectious disease called melioidosis. Bacterial ATP-binding cassette (ABC) transporters import and export a variety of molecules across bacterial cell membranes. At present, their significance in B. pseudomallei pathogenesis is poorly understood. We report here characterization of the BPSL1039-1040 ABC transporter. B. pseudomallei cultured in M9 medium supplemented with nitrate, demonstrated that BPSL1039-1040 is involved in nitrate transport for B...
2018: PloS One
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