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https://www.readbyqxmd.com/read/28985768/immune-thrombocytopenia-with-multi-organ-dysfunction-syndrome-as-a-rare-presentation-of-scrub-typhus-a-case-report
#1
Abraham M Ittyachen, Saramma P Abraham, Smitha Krishnamoorthy, Anuroopa Vijayan, Jayamohan Kokkat
BACKGROUND: Scrub typhus is an acute infectious illness caused by Orientia tsutsugamushi. It is endemic to a part of the world known as the "tsutsugamushi triangle". Humans are accidental hosts in this zoonotic disease. About a third of patients admitted with scrub typhus have evidence of multi-organ dysfunction. Multi-organ dysfunction secondary to scrub typhus carries a high mortality rate. CASE PRESENTATION: We report a 65-year old lady who was admitted in a Tertiary Care Center in the state of Kerala in India, with 7 day history of fever, myalgia and reduced urine output...
October 6, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28971766/ornithine-decarboxylase-inhibition-a-strategy-to-combat-various-diseases
#2
Priyanshu R Rai, Rakesh R Somani, Pooja S Kandpile
Ornithine decarboxylase is the first enzyme in the polyamine biosynthetic pathway. It is the rate-limiting enzyme which is included in the change of ornithine to putrescine which is the first polyamine. Polyamines (putrescine, spermidine, spermine) are natural and synthetic compounds which contains two or more amino group. Polyamines are highly implicated in cellular functions such as cell-growth & multiplication, DNA stabilization, gene transcription and translation, ion-channel activity, etc. Elevated levels of polyamines were found in highly proliferating tumour cells...
September 27, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28969414/vitamin-d-deficiency-in-refugees-in-italy
#3
L G De Filippis, I Trombetta, T Novella, M Alampi
The objective of the research is to determine 25[OH]D serum levels in refugees in Italy. In the following research we have taken into consideration the results of the monitoring of Vitamin D levels in 46 refugees of the Italian Service for protection of refugees and asylum seekers (SPRAR) system. The indicator of overall vitamin D status used was the circulating serum level of 25(OH)D. Data was analyzed using Microsoft Excel. In the refugees tested, the mean level of 25(OH)D resulted 9.18 ng/mL. The standard deviation was 4...
September 21, 2017: Reumatismo
https://www.readbyqxmd.com/read/28966914/laryngeal-paracoccidioidomycosis-presenting-as-solitary-true-vocal-fold-disease
#4
Walter de Araujo Eyer-Silva, Annelise Callmann Santana, Guilherme Almeida Rosa da Silva, Marcelo Costa Velho Mendes de Azevedo, Juliana Li Ting Matos Sun Barreto, Marina Apolloni Neumann, Izana Junqueira de Castro, Rodrigo Panno Basílio-de-Oliveira, Luciana Ferreira de Araujo, Nathane Zanineli Ré, Felipe Marques de Oliveira, Caio José de Araujo Simas, Marcos André de Sarvat, Fernando Raphael de Almeida Ferry
Paracoccidioidomycosis (PCM) is a systemic granulomatous disease caused by Paracoccidioides brasiliensis or P. lutzii. It is a neglected tropical infectious disease that poses a major public health burden in endemic areas of Latin America. Mucosae of the upper digestive and respiratory tracts are commonly involved and many patients have disease at multiple mucosal sites, with or without lung involvement. Mucosal PCM presenting as solitary true vocal fold disease is relatively rare. We present the case of a 67-year-old Brazilian forest guard who presented with a 6-month history of hoarseness and globus pharyngeus due to a solitary left true vocal fold infiltration and vegetation diagnosed as PCM...
2017: IDCases
https://www.readbyqxmd.com/read/28965490/study-roadmap-for-high-throughput-development-of-easy-to-use-and-affordable-biomarkers-as-diagnostics-for-tropical-diseases-a-focus-on-malaria-and-schistosomiasis
#5
Kokouvi Kassegne, Ting Zhang, Shen-Bo Chen, Bin Xu, Zhi-Sheng Dang, Wang-Ping Deng, Eniola Michael Abe, Hai-Mo Shen, Wei Hu, Takele Geressu Guyo, Solomon Nwaka, Jun-Hu Chen, Xiao-Nong Zhou
BACKGROUND: Interventions are currently being used against 'infectious diseases of poverty', which remain highly debilitating and deadly in most endemic countries, especially malaria, schistosomiasis, echinococcosis and African sleeping sickness. However, major limitations of current 'traditional' methods for diagnosis are neither simple nor convenient for population surveillance, and showed low sensitivity and specificity. Access to novel technologies for the development of adequate and reliable tools are expressly needed...
October 2, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28961208/how-can-elispot-add-information-to-improve-knowledge-on-tropical-diseases
#6
REVIEW
Josué da Costa Lima-Junior, Fernanda Nazaré Morgado, Fátima Conceição-Silva
Elispot has been used as an important tool for detecting immune cells' products and functions and has facilitated the understanding of host-pathogen interaction. Despite the incredible diversity of possibilities, two main approaches have been developed: the immunopathogenesis and diagnosis/prognosis of infectious diseases as well as cancer research. Much has been described on the topics of allergy, autoimmune diseases, and HIV-Aids, however, Elispot can also be applied to other infectious diseases, mainly leishmaniasis, malaria, some viruses, helminths and mycosis usually classified as tropical diseases...
September 29, 2017: Cells
https://www.readbyqxmd.com/read/28950107/comparison-between-the-gold-standard-dxa-with-calcaneal-quantitative-ultrasound-based-strategy-qus-to-detect-osteoporosis-in-an-hiv-infected-cohort
#7
Eugenia Quiros Roldan, Nigritella Brianese, Elena Raffetti, Emanuele Focà, Maria Chiara Pezzoli, Andrea Bonito, Alice Ferraresi, Paola Lanza, Teresa Porcelli, Francesco Castelli
INTRODUCTION: Osteoporosis represents one of the most frequent comorbidity among HIV patients. The current standard method for osteoporosis diagnosis is dual-energy X-ray absorptiometry. Calcaneal quantitative ultrasound can provide information about bone quality. The aims of this study are to compare these two methods and to evaluate their ability to screen for vertebral fracture. METHODS: This cross-sectional study was conducted in HIV patients attending the Clinic of Infectious and Tropical Diseases of Brescia during 2014 and who underwent lumbar/femoral dual-energy X-ray absorptiometry, vertebral fracture assessment and calcaneal quantitative ultrasound...
September 23, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28936226/challenges-in-modeling-complexity-of-neglected-tropical-diseases-a-review-of-dynamics-of-visceral-leishmaniasis-in-resource-limited-settings
#8
REVIEW
Swati DebRoy, Olivia Prosper, Austin Mishoe, Anuj Mubayi
OBJECTIVES: Neglected tropical diseases (NTD), account for a large proportion of the global disease burden, and their control faces several challenges including diminishing human and financial resources for those distressed from such diseases. Visceral leishmaniasis (VL), the second-largest parasitic killer (after malaria) and an NTD affects poor populations and causes considerable cost to the affected individuals. Mathematical models can serve as a critical and cost-effective tool for understanding VL dynamics, however, complex array of socio-economic factors affecting its dynamics need to be identified and appropriately incorporated within a dynamical modeling framework...
2017: Emerging Themes in Epidemiology
https://www.readbyqxmd.com/read/28931756/monocyte-dysregulation-and-systemic-inflammation-during-pediatric-falciparum-malaria
#9
Katherine R Dobbs, Paula Embury, John Vulule, Peter S Odada, Bruce A Rosa, Makedonka Mitreva, James W Kazura, Arlene E Dent
BACKGROUND: Inflammation and monocytes are thought to be important to human malaria pathogenesis. However, the relationship of inflammation and various monocyte functions to acute malaria, recovery from acute malaria, and asymptomatic parasitemia in endemic populations is poorly understood. METHODS: We evaluated plasma cytokine levels, monocyte subsets, monocyte functional responses, and monocyte inflammatory transcriptional profiles of 1- to 10-year-old Kenyan children at the time of presentation with acute uncomplicated malaria and at recovery 6 weeks later; these results were compared with analogous data from asymptomatic children and adults in the same community...
September 21, 2017: JCI Insight
https://www.readbyqxmd.com/read/28931128/6-year-review-of-redivi-a-prospective-registry-of-imported-infectious-diseases-in-spain
#10
José A Pérez-Molina, Ana López-Polín, Begoña Treviño, Israel Molina, Josune Goikoetxea, Marta Díaz-Menéndez, Diego Torrús, Eva Calabuig, Agustín Benito, Rogelio López-Vélez
Background: Understanding and detecting imported diseases is a priority in the prevention and management of prevalent and emergent infectious diseases acquired abroad. The +Redivi network measures the burden of imported infections in Spain and is essential for closing the gap in travel medicine. Methods: Demographic characteristics, travel information, syndromes and confirmed travel-related diagnoses were registered in a standardised online database. Results: A total of 10 767 cases of imported infectious diseases were registered between October 2009 and December 2015...
September 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28919835/high-resolution-infrared-thermography-a-new-tool-to-assess-tungiasis-associated-inflammation-of-the-skin
#11
Angela Schuster, Marlene Thielecke, Vaomalala Raharimanga, Charles Emile Ramarokoto, Christophe Rogier, Ingela Krantz, Hermann Feldmeier
BACKGROUND: Tungiasis is highly prevalent in low- and middle-income countries but remains often under diagnosed and untreated eventually leading to chronic sequels. The objective of the study was to assess whether tungiasis-associated inflammation can be detected and quantified by high-resolution infrared thermography (HRIT) and whether after removal of the parasite inflammation resolves rapidly. METHODS: Patients with tungiasis were identified through active case finding...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/28919438/molecular-targets-and-pathways-for-the-treatment-of-visceral-leishmaniasis
#12
REVIEW
Vineet Jain, Keerti Jain
Visceral leishmaniasis (VL) represents the most severe form of the tropical disease, leishmaniasis. Treatment of VL is complicated because of the few clinically approved antileishmanial drugs available; emerging resistance to first-line drugs; need for a temperature-controlled 'cold' supply chain; serious toxicity concerns over drugs such as amphotericin B; high cost of medication; and unavailability of clinically approved antileishmanial vaccines. Attacking potential molecular targets, specific to the parasite, is a vital step in the treatment of this and other infectious diseases...
September 14, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28911127/nutritional-status-of-children-from-low-income-countries-arriving-in-spain
#13
Moncef Belhassen-García, Virginia Velasco-Tirado, Amparo Lopez-Bernus, Juan Luis Muñoz Bellido, Antonio Muro, Miguel Cordero, Javier Pardo-Lledias
Background: Nutritional problems, anaemia and infectious diseases are the main causes of morbidity and mortality in children and adolescents in tropical and subtropical areas. The main objective of this study was to determine the nutritional status in children from low-income countries who migrated to Spain and the value of the usual biochemistry markers of nutrition in these children, as well as to evaluate the nutritional status associated with imported infectious diseases. Moreover, we evaluated the association between anaemia and nutrition problems...
September 1, 2017: International Health
https://www.readbyqxmd.com/read/28902487/angiostrongylus-cantonensis-agent-of-a-sometimes-fatal-globally-emerging-infectious-disease-rat-lungworm-disease
#14
Robert H Cowie
Angiostrongylus cantonensis, the rat lungworm, is a dangerous invasive species that is the agent of a potentially fatal globally emerging infectious disease. Humans are infected most commonly by ingestion, deliberately or inadvertently, of the parasite larvae in their intermediate snail hosts. The larvae make their way to the brain where they can cause severe neurological damage before eventually dying. Symptoms of the disease are diverse, making it difficult to diagnose. Treatment is primarily with corticosteroids to reduce inflammation, while treatment with anthelmintics to kill the worms remains controversial...
September 13, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28892499/effectiveness-and-economic-assessment-of-routine-larviciding-for-prevention-of-chikungunya-and-dengue-in-temperate-urban-settings-in-europe
#15
Giorgio Guzzetta, Filippo Trentini, Piero Poletti, Frederic Alexandre Baldacchino, Fabrizio Montarsi, Gioia Capelli, Annapaola Rizzoli, Roberto Rosà, Stefano Merler, Alessia Melegaro
In the last decades, several European countries where arboviral infections are not endemic have faced outbreaks of diseases such as chikungunya and dengue, initially introduced by infectious travellers from tropical endemic areas and then spread locally via mosquito bites. To keep in check the epidemiological risk, interventions targeted to control vector abundance can be implemented by local authorities. We assessed the epidemiological effectiveness and economic costs and benefits of routine larviciding in European towns with temperate climate, using a mathematical model of Aedes albopictus populations and viral transmission, calibrated on entomological surveillance data collected from ten municipalities in Northern Italy during 2014 and 2015...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28888883/host-responses-and-bacterial-colonization-following-inoculation-of-pasteurella-multocida-p52-strain-into-unvaccinated-and-aluminum-hydroxide-gel-hemorrhagic-septicemia-vaccinated-mice
#16
Mamta Singh, Rishendra Verma, Ramane Sangram Pandit, Najeeb Ul Tarfain
Hemorrhagic septicemia is a highly infectious and contagious disease caused by Pasteurella multocida serogroup B:2 in tropical Asian and African countries. The acute inflammatory responses induced by Pasteurella multocida are the main cause of death in hemorrhagic septicemia. Therefore, present study was undertaken to examine the blood cytokine expression profiles (TNF-α, IL-1β, and IL-6), bacterial colonization and histopathological changes of intraperitoneally and subcutaneously challenged vaccinated and unvaccinated mice with 10(2) CFU of P...
October 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28885939/outcomes-from-u-s-military-supported-overseas-training-rotations-in-tropical-medicine-and-global-health-2006-2015
#17
James D Mancuso, Eric C Garges, Patrick W Hickey, Rodney L Coldren, Amy K Korman, Lisa W Keep, Robert F DeFraites, Jose L Sanchez
BACKGROUND: Since 2006, the Division of Tropical Public Health at the Uniformed Services University (USU) has sponsored the Tropical Medicine Training Program (TMTP). Despite practice guidelines stating that global health education should include the collection and evaluation of data on the impact of the training experiences, no quantitative evaluation of program outcomes had previously occurred. The objective of this report was to evaluate TMTP outcomes to guide program improvement. METHODS: We developed an anonymous, web-based survey to assess program outcomes as part of routine program evaluation...
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28882532/helminthic-infections-in-returning-travelers-and-migrants-with-eosinophilia-diagnostic-value-of-medical-history-eosinophil-count-and-ige
#18
Helmut J F Salzer, Thierry Rolling, Christof D Vinnemeier, Egbert Tannich, Stefan Schmiedel, Marylyn M Addo, Jakob P Cramer
OBJECTIVES: Eosinophilia in travelers and migrants returning from the tropics is often associated with invasive helminthic infections. Total IgE is considered a useful additional diagnostic parameter; however, both parameters are also increased in various other non-helminthic diseases. METHODS: We retrospectively evaluated travelers and migrants seen at our department between September 2007 and May 2014. Patients with an absolute eosinophil count ≥500 cells/μl were considered for further analyses...
September 4, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/28875505/atlantic-bats-a-dataset-of-bat-communities-from-the-atlantic-forests-of-south-america
#19
Renata de Lara Muylaert, Richard D Stevens, Carlos Eduardo Lustosa Esbérard, Marco Aurelio Ribeiro Mello, Guilherme Siniciato Terra Garbino, Luiz H Varzinczak, Deborah Faria, Marcelo de Moraes Weber, Patricia Kerches Rogeri, André Luis Regolin, Hernani Fernandes Magalhães de Oliveira, Luciana de Moraes Costa, Marília A S Barros, Gilberto Sabino-Santos, Mara Ariane Crepaldi de Morais, Vinicius Silva Kavagutti, Fernando C Passos, Emma-Liina Marjakangas, Felipe Gonçalves Motta Maia, Milton Cezar Ribeiro, Mauro Galetti
Bats are the second most diverse mammal order and they provide vital ecosystem functions (e.g., pollination, seed dispersal, and nutrient flux in caves) and services (e.g., crop pest suppression). Bats are also important vectors of infectious diseases, harboring more than 100 different virus types. In the present study, we compiled information on bat communities from the Atlantic Forests of South America, a species-rich biome that are highly threatened by habitat loss and fragmentation. ATLANTIC BATS dataset comprises 135 quantitative studies carried out in 205 sites, which cover most vegetation types of the tropical and subtropical Atlantic Forest: dense ombrophilous forest, mixed ombrophilous forest, semideciduous forest, deciduous forest, savanna, steppe, and open ombrophilous forest...
September 6, 2017: Ecology
https://www.readbyqxmd.com/read/28867257/oropharyngeal-candidiasis-prevalence-among-hiv-infected-patients-at-the-teaching-hospital-of-treichville-abidjan-c%C3%A3-te-d-ivoire
#20
A Konaté, P C M Barro-Kiki, K F Kassi, K E Angora, H Vanga-Bosson, V Djohan, A V Bédia-Tanoh, A J S Miézan, W Yavo, E I H Menan
AIM OF THE STUDY: The aim of this study was to determine the mycological profile of oropharyngeal candidiasis among HIV-infected patients from Internal Medicine, Infectious and Tropical Diseases, and Pneumo-Phthisiology Diseases departments of the Teaching Hospital of Treichville in Abidjan, Côte d'Ivoire. PATIENTS AND METHODS: This was a cross-sectional study carried out on patients with lesions suggestive of oropharyngeal candidiasis from October 2010 to April 2011...
August 31, 2017: Journal de Mycologie Médicale
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