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https://www.readbyqxmd.com/read/29765996/an-in-vitro-study-on-curcumin-delivery-by-nano-micelles-for-esophageal-squamous-cell-carcinoma-kyse-30
#1
Sare Hosseini, Jamshidkhan Chamani, Hamidreza Rahimi, Navid Azmoodeh, Faezeh Ghasemi, Porya Hassan Abadi
Background: The incidence of esophageal squamous cell carcinoma (ESCC) is increasing, causing catastrophic health burdens on communities. Curcumin has shown promise as a therapeutic agent in the treatment of colon, colorectal, pancreatic, and esophageal cancers but it has very poor bioavailability. The application of nano-carriers as drug delivery systems increases curcumin's bioavailability. Cyclin D1 is overexpressed in ESCC and curcumin may change its expression. Methods: In this study, the effect of SinaCurcumin®, a novel nano-micelle product containing 80 mg curcumin, on the growth of KYSE-30 cells and expression of cyclin D1, was investigated...
April 2018: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29719390/smart-polymeric-nanoparticles-with-ph-responsive-and-peg-detachable-properties-for-co-delivering-paclitaxel-and-survivin-sirna-to-enhance-antitumor-outcomes
#2
Mingji Jin, Guangming Jin, Lin Kang, Liqing Chen, Zhonggao Gao, Wei Huang
Background: The co-delivery of chemotherapeutic agents and small interfering RNA (siRNA) within one cargo can enhance the anticancer outcomes through its synergistic therapeutic effects. Materials and methods: We prepared smart polymeric nanoparticles (NPs) with pH-responsive and poly(ethylene glycol) (PEG)-detachable properties to systemically co-deliver paclitaxel (PTX) and siRNA against survivin gene for lung cancer therapy. The cationic polyethyleneimine-block-polylactic acid (PEI-PLA) was first synthesized and characterized, with good biocompatibility...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29719052/effect-of-single-walled-carbon-nanotubes-on-cytochrome-p450-activity-in-human-liver-microsomes-in-vitro
#3
Yuki Asai, Yukiko Sakakibara, Rina Inoue, Rikako Inoue, Masayuki Nadai, Miki Katoh
Single-walled carbon nanotubes (SWCNTs) are made from a rolled single sheet of graphene with a diameter in the nanometer range. SWCNTs are potential carriers for drug delivery systems because antibodies or drugs can be loaded on their surface; however, their effect on the activities of cytochrome P450 (CYP) remains unclear. The aim of this study was to investigate the effect of two kinds of SWCNTs with different lengths (FH-P- and SO-SWCNTs) on human CYP activity. In addition, other nano-sized carbon materials, such as carbon black, fullerene-C60 , and fullerene-C70 were also evaluated to compare their effects on CYP activities...
May 2, 2018: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/29625422/paclitaxel-and-di-fluorinated-curcumin-loaded-in-albumin-nanoparticles-for-targeted-synergistic-combination-therapy-of-ovarian-and-cervical-cancers
#4
Kaustubh A Gawde, Samaresh Sau, Katyayani Tatiparti, Sushil K Kashaw, Mohammad Mehrmohammadi, Asfar S Azmi, Arun K Iyer
Paclitaxel (PTX) encapsulated in albumin (Abraxane® ) is an FDA approved frontline nano-formulation for treating advance metastatic pancreatic, lung and breast cancers. Currently in clinic, Abraxane® is being used as a one of the components of combination therapy regimens. On the other hand, difluorinated curcumin (CDF) is a novel and potent synthetic curcumin analogue that is being evaluated for several malignancies including pancreatic, liver, ovarian and breast cancers. To improve the bioavailability and targeting ability of hydrophobic PTX and CDF, we have encapsulated them in folic acid decorated bovine serum albumin nanoparticles, namely FA-BSA-PTX and FA-BSA-CDF, respectively...
March 28, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29601975/application-of-a-simple-desolvation-method-to-increase-the-formation-yield-physical-stability-and-hydrophobic-drug-encapsulation-capacity-of-chitosan-based-nanoparticles
#5
Liqun Jiang, Huajian Duan, Xiangxiang Ji, Tingyu Wang, Yun Wang, Jingying Qiu
As one of the classical nano drug carriers, chitosan-based nanoparticles (CsNps) are getting increasing attentions for their non-toxicity, biocompatibility and biodegradability. The ionotropic gelation is the most favorable method for CsNps preparation, while it's beset by some issues, i.e. low particle formation yield, poor physical stability and low hydrophobic drug loading capacity. To solve these problems, a simple desolvation method was attempted in this study for CsNps preparation. Using this method, an increased formation yield of CsNps (about 100%) could be obtained, and after diluting the particles by various buffers (PBS7...
March 27, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29592881/nano-engineered-mesenchymal-stem-cells-increase-therapeutic-efficacy-of-anticancer-drug-through-true-active-tumor-targeting
#6
Buddhadev Layek, Tanmoy Sadhukha, Jayanth Panyam, Swayam Prabha
Tumor-targeted drug delivery has the potential to improve therapeutic efficacy and mitigate non-specific toxicity of anticancer drugs. However, current drug delivery approaches rely on inefficient passive accumulation of the drug carrier in the tumor. We have developed a unique, truly active tumor targeting strategy that relies on engineering mesenchymal stem cells (MSCs) with drug-loaded nanoparticles. Our studies using the A549 orthotopic lung tumor model show that nano-engineered MSCs carrying the anticancer drug paclitaxel (PTX) home to tumors and create cellular drug depots that release the drug payload over several days...
March 28, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29571289/paclitaxel-and-curcumin-coadministration-in-novel-cationic-pegylated-niosomal-formulations-exhibit-enhanced-synergistic-antitumor-efficacy
#7
Ashraf Alemi, Javad Zavar Reza, Fateme Haghiralsadat, Hossein Zarei Jaliani, Mojtaba Haghi Karamallah, Seyed Ahmad Hosseini, Somayeh Haghi Karamallah
BACKGROUND: The systemic administration of cytotoxic chemotherapeutic agents for cancer treatment often has toxic side effects, limiting the usage dose. To increase chemotherapeutic efficacy while reducing toxic effects, a rational design for synergy-based drug regimens is essential. This study investigated the augmentation of therapeutic effectiveness with the co-administration of paclitaxel (PTX; an effective chemotherapeutic drug for breast cancer) and curcumin (CUR; a chemosensitizer) in an MCF-7 cell line...
March 23, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29534020/copper-free-click-chemistry-based-synthesis-and-characterization-of-carbonic-anhydrase-ix-anchored-albumin-paclitaxel-nanoparticles-for-targeting-tumor-hypoxia
#8
Katyayani Tatiparti, Samaresh Sau, Kaustubh A Gawde, Arun K Iyer
Triple negative breast cancer (TNBC) is a difficult to treat disease due to the absence of the three unique receptors estrogen, progesterone and herceptin-2 (HER-2). To improve the current therapy and overcome the resistance of TNBC, there is unmet need to develop an effective targeted therapy. In this regard, one of the logical and economical approaches is to develop a tumor hypoxia-targeting drug formulation platform for selective delivery of payload to the drug-resistant and invasive cell population of TNBC tumors...
March 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29530390/design-and-tuning-of-a-cell-penetrating-albumin-derivative-as-a-versatile-nanovehicle-for-intracellular-drug-delivery
#9
Shota Ichimizu, Hiroshi Watanabe, Hitoshi Maeda, Keisuke Hamasaki, Yuka Nakamura, Victor Tuan Giam Chuang, Ryo Kinoshita, Kento Nishida, Ryota Tanaka, Yuki Enoki, Yu Ishima, Akihiko Kuniyasu, Yoshihiro Kobashigawa, Hiroshi Morioka, Shiro Futaki, Masaki Otagiri, Toru Maruyama
Human serum albumin (HSA) is a superior carrier for delivering extracellular drugs. However, the development of a cell-penetrating HSA remains a great challenge due to its low membrane permeability. We report herein on the design of a series of palmitoyl-poly-arginine peptides (CPPs) and an evaluation of their cell-penetrating effects after forming a complex with HSA for use in intracellular drug delivery. The palmitoyl CPPs forms a stable complex with HSA by anchoring itself to the high affinity palmitate binding sites of HSA...
May 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29490409/effects-of-low-and-high-dose-chemotherapy-agents-on-thrombogenic-properties-of-extracellular-vesicles-derived-from-breast-cancer-cell-lines
#10
Anat Aharon, Anni Rebibo Sabbah, Liron Issman, Hila Berkovich, Reem Copty, Yeshayahu Talmon, Benjamin Brenner
BACKGROUND:  The involvement of extracellular vesicles (EVs) in cancer-associated thrombosis (CT) is unclear. This study aimed to explore the properties of EVs derived from breast cancer (BC) cells following exposure to high- or low-dose chemotherapeutic agents and evaluate thrombogenic effects of these EVs on endothelial cells (ECs). METHODS:  EVs were isolated from BC cell lines (non-metastatic MCF7, high-metastatic MDA-MB-231), pre-exposed to serum-free medium (control), with or without increasing doses of doxorubicin or paclitaxel...
March 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29478415/development-and-evaluation-of-novel-tumor-targeting-paclitaxel-loaded-nano-carriers-for-ovarian-cancer-treatment-in-vitro-and-in-vivo
#11
Shu Yao, Li Li, Xuan-Tao Su, Kai Wang, Zai-Jun Lu, Cun-Zhong Yuan, Jin-Bo Feng, Shi Yan, Bei-Hua Kong, Kun Song
BACKGROUND: Ovarian cancer is the most leading cause of death and the third most common gynecologic malignancy in women. Traditional chemotherapy has inevitable drawbacks of nonspecific tumor targeting, high toxicity, and poor therapeutic efficiency. In order to overcome such shortcomings, we prepared a novel nano-carrier drug-delivery system to enhance the anti-tumor efficiency. METHODS: In vitro characterizations of nano-carriers were determined by TEM, DLS. Cell viability was measured by MTT method...
February 26, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29477643/paclitaxel-controlled-delivery-using-a-ph-responsive-functional-aunp-block-copolymer-vesicular-nanocarrier-composite-system
#12
Athina Liaskoni, Athina Angelopoulou, Efstathia Voulgari, Maria-Teodora Popescu, Constantinos Tsitsilianis, Konstantinos Avgoustakis
Paclitaxel (PTX)-loaded gold nanoparticles functionalized with mercaptooctanoic acid (MOA) and folic acid (FA) (AuMOA-FA) were encapsulated within pH-sensitive poly(2-vinylpyridine)-b-poly(ethylene oxide) (P2VP-PEO) vesicles with the aim to develop a more selective injectable nano-formulation for PTX, lacking the side effects of the conventional PTX delivery system. The size of the resulting composite vesicles was lower than 200 nm, i.e. it is suitable for tumor targeting applications taking advantage of the enhanced permeability and retention (EPR) effect...
May 30, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29448632/mpeg-cs-bmi-1rnai-nanoparticles-synthesis-and-its-targeted-inhibition-effect-on-cd133-laryngeal-stem-cells
#13
Xudong Wei, Jian He, Jingyu Wang, Wei Wang
Previous studies have confirmed that CD133+ cells in laryngeal tumor tissue have the characteristics of cancer stem cells. Bmi-1 gene expression is central to the tumorigenicity of CD133+ cells. In this study, we tried to develop a new siRNA carrier system using chitosan-methoxypolyethylene nanoparticles (CS-mPEG-NPs) that exhibit higher tumor-targeting ability and enhanced gene silencing efficacy in CD133+ tumor stem cells. It is hoped to block the self-renewal and kill the stem cells of laryngeal carcinoma...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29423264/a-biomimetic-and-ph-sensitive-polymeric-micelle-as-carrier-for-paclitaxel-delivery
#14
Boxuan Ma, Weihua Zhuang, Gongyan Liu, Yunbing Wang
As nano-scale drug delivery systems, smart micelles that are sensitive to specific biological environment and allowed for target site-triggered drug release by reversible stabilization of micelle structure are attractive. In this work, a biocompatible and pH-sensitive copolymer is synthesized through bridging poly (2-methacryloyloxyethyl phosphorylcholine) (PMPC) block and poly (D, L -lactide) (PLA) block by a benzoyl imine linkage ( Blink ). Biomimetic micelles with excellent biocompatibility based on such PLA- Blink -PMPC copolymer are prepared as carriers for paclitaxel (PTX) delivery...
February 2018: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29382898/evaluation-of-cell-penetrating-peptide-coated-mn-zns-nanoparticles-for-paclitaxel-delivery-to-cancer-cells
#15
N Sanoj Rejinold, Yunho Han, Jisang Yoo, Hae Yong Seok, Ji Ho Park, Yeu-Chun Kim
This work aimed at formulating paclitaxel (PTX) loaded cell penetrating peptide (CPP) coated Mn doped ZnS nanoparticles (Mn:ZnS NPs) for improved anti-cancer efficacy in vitro and in vivo. The developed PTX loaded Mn:ZnS NPs with different CPPs (PEN, pVEC and R9) showed enhanced anti-cancer effect compared to bare PTX, which has been validated by MTT assay followed by apoptosis assay and DNA fragmentation analysis. The in vivo bio-distribution and anti-cancer efficacy was studied on breast cancer xenograft model showing maximum tumor localization and enhanced therapeutic efficacy with R9 coated Mn:ZnS NPs (R9:Mn:ZnS NPs) and was confirmed by H/E staining...
January 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317344/redox-responsive-micelles-from-disulfide-bond-bridged-hyaluronic-acid-tocopherol-succinate-for-the-treatment-of-melanoma
#16
Junping Xia, Yunai Du, Liping Huang, Birendra Chaurasiya, Jiasheng Tu, Thomas J Webster, Chunmeng Sun
Nanotechnology-based chemotherapy is efficient in cancer treatment due to the targeted delivery of small molecules via nano-carriers, which are usually regarded as "inert". However, nano-materials are more preferred as carriers since many cause synergistic anti-tumor effects along with the drug cargo. In this study, a "bioactive" tocopherol succinate (TOS) was grafted to hyaluronic acid (HA) via of disulfide bonds to obtain HA-ss-TOS conjugates which can assemble into nano-micelles but dissociate when exposed to reducing environments in vitro and in vivo...
January 6, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29215573/the-use-of-liposomes-and-nanoparticles-as-drug-delivery-systems-to-improve-cancer-treatment-in-dogs-and-cats
#17
REVIEW
Katarzyna Zabielska-Koczywąs, Roman Lechowski
BACKGROUND: Cancer remains a leading cause of death in companion animals. In human medicine, liposomes and nanoparticles have been extensively investigated as drug delivery systems (DDS) for anticancer agents due to their ability to target cancerous cells and reduce the negative side effects of free cytostatic drugs. In this review, the authors discuss the results of clinical trials using liposomes and polymer-based nanoparticles as DDS to improve cancer treatment in dogs and cats, indicating which ones seem worth further evaluation...
December 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29158820/ph-sensitive-nano-complexes-overcome-drug-resistance-and-inhibit-metastasis-of-breast-cancer-by-silencing-akt-expression
#18
Jieying Yin, Tianqun Lang, Dongmei Cun, Zhong Zheng, Yan Huang, Qi Yin, Haijun Yu, Yaping Li
The therapy of breast cancer is encumbered by drug resistance and metastasis, which can be due to a defective PI3K/AKT/mTOR signaling pathway. This study was aimed at improving the anti-cancer effect of the chemotherapeutic agent paclitaxel (PTX) on the drug resistant and metastatic breast cancer by co-delivering PTX and a siRNA, siAkt, directed at silencing the Akt expression. Methods: The pH-sensitive amphiphilic polymer, poly [(1,4-butanediol)-diacrylate-β-N, N-diisopropylethylenediamine]-polyethyleneimine (BDP) was synthesized...
2017: Theranostics
https://www.readbyqxmd.com/read/29103516/1-3%C3%AE-glucan-anchored-paclitaxel-loaded-chitosan-nanocarrier-endows-enhanced-hemocompatibility-with-efficient-anti-glioblastoma-stem-cells-therapy
#19
Pankaj K Singh, Anup K Srivastava, Atul Dev, Babita Kaundal, Subhasree Roy Choudhury, Surajit Karmakar
Recurrence of glioblastoma is one of the major concerns due to its heterogeneous nature and association of Glioma Initiating stem-like Cells (GICs). Nanoparticles mediated delivery of chemotherapeutic agent targeting both cancer and glioma stem cells could provide a solution to recurrent malignancies of the glioblastoma tumor. The approach described here provides enhanced chemotherapeutic potency utilizing 1,3β-Glucan as an outer shell to the chitosan nanoparticles (Cs-NPs) loaded with paclitaxel to prevent hemolysis with, the core-shell nano-structure (Cs-PTX-NP) enabling effective chemotherapy against malignant glioblastoma...
January 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29101359/identification-of-a-peptide-peptide-binding-motif-in-the-coating-of-nab-paclitaxel-nanoparticles-with-clinical-antibodies-bevacizumab-rituximab-and-trastuzumab
#20
John T Butterfield, Hidong Kim, Daniel J Knauer, Wendy K Nevala, Svetomir N Markovic
Antibody directed chemotherapy (ADC) takes advantage of the selectivity of the monoclonal antibody to increase the efficacy of the chemotherapeutic agent, while reducing toxicity. Previously we described three nab-paclitaxel (Abraxane) nanoparticles coated with commercial monoclonal antibodies. Identifying the binding sites responsible for these particles could allow reverse engineering of nab-paclitaxel binding antibodies, creating a modular platform for antibody directed chemotherapeutic nanoparticles. Herein, Biacore surface plasmon resonance is used to identify an antibody binding site, HSA Peptide 40, on human serum albumin with nanomolar affinity for all three monoclonal antibodies...
November 3, 2017: Scientific Reports
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