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Nano paclitaxel

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https://www.readbyqxmd.com/read/28069192/acoustic-cavitation-induced-generation-of-stabilizer-free-extremely-stable-reduced-graphene-oxide-nanodispersion-for-efficient-delivery-of-paclitaxel-in-cancer-cells
#1
Renu Geetha Bai, Kasturi Muthoosamy, Fiona Natalia Shipton, Sivakumar Manickam
Graphene is one of the highly explored nanomaterials due to its unique and extraordinary properties. In this study, by utilizing a hydrothermal reduction method, graphene oxide (GO) was successfully converted to reduced graphene oxide (RGO) without using any toxic reducing agents. Following this, with the use of ultrasonic cavitation, profoundly stable few layer thick RGO nanodispersion was generated without employing any stabilizers or surfactants. During ultrasonication, shockwaves from the collapse of bubbles cause a higher dispersing energy to the graphene nanosheets which surpass the forces of Van der Waal's and π-π stacking and thus pave the way to form a stable aqueous nanodispersion of graphene...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28060268/a-facile-and-efficient-approach-for-the-production-of-reversible-disulfide-cross-linked-micelles
#2
Yuanpei Li, Gaurav Bharadwaj, Joyce S Lee
Nanomedicine is an emerging form of therapy that harnesses the unique properties of particles that are nanometers in scale for biomedical application. Improving drug delivery to maximize therapeutic outcomes and to reduce drug-associated side effects are some of the cornerstones of present-day nanomedicine. Nanoparticles in particular have found a wide application in cancer treatment. Nanoparticles that offer a high degree of flexibility in design, application, and production based on the tumor microenvironment are projected to be more effective with rapid translation into clinical practice...
December 23, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28038747/efficient-delivery-of-paclitaxel-into-asgpr-over-expressed-cancer-cells-using-reversibly-stabilized-multifunctional-pullulan-nanoparticles
#3
Liping Huang, Yutong Wang, Xiang Ling, Birendra Chaurasiya, Chen Yang, Yunai Du, Jiasheng Tu, Yerong Xiong, Chunmeng Sun
Core-crosslinked pullulan nanoparticles (Pull-LA-CLNPs) were synthesized by the reduction-sensitive strategy for paclitaxel (PTX) delivery. Pull-LA-CLNPs showed high stability against extensive dilution, high salt concentration and organic solvent. In vitro drug release study showed that PTX release from Pull-LA-NPs at pH 7.4 and 5.4 was significantly influenced by addition of DTT. In cytotoxicity assay, PTX loaded Pull-LA-CLNPs showed a low IC50 at 0.51μg/mL. Asialoglycoprotein receptor (ASGPR) competitive inhibition and intracellular distribution studies performed by flow cytometer, fluorescence microscope and confocal laser scanning microscopy (CLSM) showed that Pull-LA-NPs could be efficiently taken up by the cells via ASGPR-mediated endocytosis and mainly distributed in cytoplasm...
March 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28036254/targeted-delivery-of-nano-ptx-to-the-brain-tumor-associated-macrophages
#4
Lei Zou, Youhua Tao, Gregory Payne, Linh Do, Tima Thomas, Juan Rodriguez, Huanyu Dou
Nanoparticles containing mixed lipid monolayer shell, biodegradable polymer core and rabies virus glycoprotein (RVG) peptide as brain targeting ligand, were developed for brain targeted delivery of paclitaxel (PTX) to treat malignant glioma. RVG conjugated PTX loaded NPs (RVG-PTX-NPs) had the desirable size (~140 nm), narrow size distribution and spherical shape. RVG-PTX-NPs showed poor uptake by neurons and selective targeting to the brain tumor associated macrophages (TAMs) with controlled release and tumor specific toxicity...
December 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/28024581/development-and-evaluation-of-targeting-ligands-surface-modified-paclitaxel-nanocrystals
#5
Jeong Sun Sohn, Doo-Soo Yoon, Jun Youn Sohn, Jeong-Sook Park, Jin-Seok Choi
To overcome the toxicity of excipient or blank nanoparticles for drug delivery nano-system, the surface modified paclitaxel nanocrystals (PTX-NC) have been developed. PTX-NCs were prepared by nano-precipitation method. The surface of PTX-NCs were modified by grafting with apo-transferrin (Tf) or hyaluronic acid (HA). The physical properties of PTX-NCs were evaluated by field emission scanning electron microscope (FE-SEM), zeta-sizer, zeta-potential, differential scanning calorimetry (DSC) and Fourier transform infrared (FT-IR) spectrometry...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27976583/enhanced-antiglioma-efficacy-of-ultrahigh-loading-capacity-paclitaxel-prodrug-conjugate-self-assembled-targeted-nanoparticles
#6
Yan Jiang, Xiuzhen Wang, Xin Liu, Wei Lv, Hongjuan Zhang, Mingwan Zhang, Xinrui Li, Hongliang Xin, Qunwei Xu
Glioblastoma multiforme (GBM) presents one of the most lethal brain tumor with a dismal prognosis. And nanodrug delivery system (nano-DDS) have raised a lot of concern, while the conventional nanoformulations addressed many limitations, especially the low drug loading capacity and poor stability in vivo. Herein, we proposed PTX prodrug (PTX-SS-C18) conjugate self-assembled nanoparticles (PSNPs) functionalized with Pep-1, glioma homing peptide, to overcome the blood brain tumor barrier (BBTB) via interleukin 13 receptor α2 (IL-13Rα2)-mediated endocytosis for targeting GMB...
December 23, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27942215/synergistic-locoregional-chemoradiotherapy-using-a-composite-liposome-in-gel-system-as-an-injectable-drug-depot
#7
Shruti GuhaSarkar, Kamal Pathak, Niyati Sudhalkar, Prachi More, Jayant Sastri Goda, Vikram Gota, Rinti Banerjee
The use of radiosensitizers in clinical radiotherapy is limited by systemic toxicity. The biopolymeric, biodegradable, injectable liposome-in-gel-paclitaxel (LG-PTX) system was developed for regional delivery of the radiosensitizer paclitaxel (PTX), and its efficacy was evaluated with concurrent fractionated radiation. LG-PTX is composed of nano-sized drug-loaded fluidizing liposomes, which are incorporated into a porous biodegradable gellan hydrogel. This allows enhanced drug permeation while maintaining a localization of the drug depot...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27924295/dataset-on-the-physical-characterization-of-biopolymer-coated-magnetic-nanoparticles
#8
Shazia Bano, Muhammad Afzal
The data presented in this article is related to the research article entitled "Paclitaxel loaded magnetic nanocomposites with folate modified chitosan/carboxymethyl surface; a vehicle for imaging and targeted drug delivery" (S. Bano, M. Afzal, M.M. Waraich, K. Alamgir, S. Nazir, 2016) [1]. It contains the absorbance spectra, band gap energies of pure nickel-ferrite nano cores (NFs), and calibration curve of Paclitaxel. Thermal stability analysis of pure NFs, chitosan (CS) and carboxymethyl cellulose (CMC)-conjugated NFs samples is also included in the data...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27913307/urothelium-adherent-ion-triggered-liposome-in-gel-system-as-a-platform-for-intravesical-drug-delivery
#9
Shruti GuhaSarkar, Prachi More, Rinti Banerjee
Instillations of therapeutic agents into the urinary bladder have limited efficacy due to drug washout and inadequate attachment to and penetration into the bladder wall. Instilled nanoparticles alone have low stability and high susceptibility to washout, while gel-based systems are difficult to administer and retain. To overcome disadvantages of current technologies, a biodegradable, in situ-gelling liposome-in-gel (LP-Gel) system was developed for instillation into the bladder, composed of nano-sized, fluidizing liposomes incorporated into a "smart" biopolymeric, urine-triggered hydrogel...
November 29, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27895754/evaluation-of-the-efficacy-of-paclitaxel-with-curcumin-combination-in-ovarian-cancer-cells
#10
Zeng Liu, Yuan-Yuan Zhu, Zhao-Yuan Li, Si-Qing Ning
The aim of the present study was to evaluate the efficacy of paclitaxel combined with curcumin (CUR) against drug resistance in ovarian cancer cells. PLGA-phospholipid-PEG nanoparticles were prepared using the nano precipitation method. The size and morphology of the nanoparticles were determined using a transmission electron microscope and particle size analyzer. The encapsulation efficiency of nanoparticles was determined using the ultrafiltration centrifugation method. The dialysis method was used to study the release of PLGA-phospholipid-PEG nanoparticles...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27835907/biodegradable-double-targeted-ptx-mpeg-plga-nanoparticles-for-ultrasound-contrast-enhanced-imaging-and-antitumor-therapy-in-vitro
#11
Jing Ma, Ming Shen, Chang Song Xu, Ying Sun, You Rong Duan, Lian Fang Du
A porous-structure nano-scale ultrasound contrast agent (UCA) was made of monomethoxypoly (ethylene glycol)-poly (lactic-co-glycolic acid) (mPEG-PLGA), and modified by double-targeted antibody: anti-carcinoembryonic antigen (CEA) and anti-carbohydrate antigen 19-9 (CA19-9), as a double-targeted nanoparticles (NPs). Anti-tumor drug paclitaxel (PTX) was encapsulated in the double-targeted nanoparticles (NPs). The morphor and release curve were characterized. We verified a certain anticancer effect of PTX-NPs through cytotoxicity experiments...
November 9, 2016: Oncotarget
https://www.readbyqxmd.com/read/27834116/ethanol-based-proliposome-delivery-systems-of-paclitaxel-for-in-vitro-application-against-brain-cancer-cells
#12
Mohammad Najlah, Mohit Jain, Ka-Wai Wan, Waqar Ahmed, Mohamed Albed Alhnan, David A Phoenix, Kevin M G Taylor, Abdelbary Elhissi
In this study the anticancer activity of paclitaxel-loaded nano-liposomes on glioma cell lines was investigated. Soya phosphatidylcholine:cholesterol (SPC:Chol), hydrogenated soya phosphatidylcholine:cholesterol (HSPC:Chol) or dipalmitoylphosphatidylcholine:cholesterol (DPPC:Chol) in 1:1 mole ratio were used to prepare ethanol-based proliposomes. Following hydration of proliposomes, the size of resulting vesicles was subsequently reduced to nanometer scale via probe-sonication. The resulting formulations were characterized in terms of size, zeta potential and morphology of the vesicles, and entrapment efficiency of paclitaxel (PX) as well as the final pH of the preparations...
December 14, 2016: Journal of Liposome Research
https://www.readbyqxmd.com/read/27753601/biological-effect-on-restenosis-and-vascular-healing-of-encapsulated-paclitaxel-nanocrystals-delivered-via-coated-balloon-technology-in-the-familial-hypercholesterolaemic-swine-model-of-in-stent-restenosis
#13
Yanping Cheng, Masahiko Shibuya, Jenn McGregor, Gerard B Conditt, Geng-Hua Yi, Greg L Kaluza, William Gray, Manish Doshi, Prakash Sojitra, Juan F Granada
AIMS: The aim of this study was to evaluate the biological efficacy of a novel lower-dose (2.5 µg/mm2) encapsulated paclitaxel nanocrystal-coated balloon (Nano-PCB) in the familial hypercholesterolaemic swine (FHS) model of iliofemoral in-stent restenosis. METHODS AND RESULTS: Nano-PCB pharmacokinetics were assessed in 20 femoral arteries (domestic swine). Biological efficacy was evaluated in ten FHS: 14 days following bare metal stent implantation each stent segment was randomised to a clinically available PCB (IN...
October 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27597657/exceedingly-higher-co-loading-of-curcumin-and-paclitaxel-onto-polymer-functionalized-reduced-graphene-oxide-for-highly-potent-synergistic-anticancer-treatment
#14
Kasturi Muthoosamy, Ibrahim Babangida Abubakar, Renu Geetha Bai, Hwei-San Loh, Sivakumar Manickam
Metastasis of lung carcinoma to breast and vice versa accounts for one of the vast majority of cancer deaths. Synergistic treatments are proven to be the effective method to inhibit malignant cell proliferation. It is highly advantageous to use the minimum amount of a potent toxic drug, such as paclitaxel (Ptx) in ng/ml together with a natural and safe anticancer drug, curcumin (Cur) to reduce the systemic toxicity. However, both Cur and Ptx suffer from poor bioavailability. Herein, a drug delivery cargo was engineered by functionalizing reduced graphene oxide (G) with an amphiphilic polymer, PF-127 (P) by hydrophobic assembly...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27546165/enhanced-anti-tumor-efficacy-of-paclitaxel-with-pegylated-lipidic-nanocapsules-in-presence-of-curcumin-and-poloxamer-in-vitro-and-in-vivo-studies
#15
Mohammed Anwar, Sohail Akhter, Neha Mallick, Sharmistha Mohapatra, Sobiya Zafar, M Moshahid A Rizvi, Asgar Ali, Farhan J Ahmad
Cancer chemotherapeutic drug containing PEGylated lipidic nanocapsules (D-LNCs) were formulated by the controlled addition of organic phase (combined solution of paclitaxel and curcumin in a mixture of oleic acid and MPEG2000-DSPE (90:2.5 molar ratio) in acetone) to the aqueous phase (consist of Poloxamer 407 as emulsifying agents and glycerol as a co-solvent) at a temperature of 55-60°C followed by evaporation of organic solvent. The obtained pre-colloidal dispersion of D-LNCs was processed through high pressure homogenization to get more uniformly and nano-sized particles...
August 19, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27541441/electroneutral-composite-polymersomes-self-assembled-by-amphiphilic-polyphosphazenes-for-effective-mir-200c-in%C3%A2-vivo-delivery-to-inhibit-drug-resistant-lung-cancer
#16
Yan Peng, Xiumei Zhu, Liyan Qiu
MiR-200c has been confirmed to display remarkable effects on proliferation inhibition and apoptosis induction of certain cancer cells, but the main challenge for its successful translation into the clinic remains its effective delivery to the action site in vivo. In this study, a novel composite polyphosphazene vesicle system composed of amphiphilic [NP(PEG)0.3(EAB)1.7]n (PEEP) and weakly cationic [NP(PEG)0.5(DPA)1.5]n (PEDP) was prepared via a very simple dialysis method. The loading of miR-200c was accomplished with high efficiency by taking advantage of the combination effect of physical encapsulation and electrostatic interaction between vectors and miR-200c...
November 2016: Biomaterials
https://www.readbyqxmd.com/read/27516149/effects-of-paclitaxel-nanocrystals-surface-charge-on-cell-internalization
#17
Jin-Seok Choi, Jeong-Sook Park
In this study, we investigated the influence of paclitaxel nanocrystals (PTX-NC) surface charge on cell internalization and cell cytotoxicity. PTX-NCs were prepared using the nano-precipitation method. The surface-modified PTX-NCs were prepared using an absorption method with positively charged poly(allylamine hydrochloride) (PAH) and negatively charged poly(sodium 4-styrenesulfonate) (PSS). The morphologies of the surface-modified and unmodified PTX-NCs were characterized by field emission scanning electron microscopy...
October 10, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27490088/self-assembled-redox-dual-responsive-prodrug-nanosystem-formed-by-single-thioether-bridged-paclitaxel-fatty-acid-conjugate-for-cancer-chemotherapy
#18
Cong Luo, Jin Sun, Dan Liu, Bingjun Sun, Lei Miao, Sara Musetti, Jing Li, Xiaopeng Han, Yuqian Du, Lin Li, Leaf Huang, Zhonggui He
Chemotherapeutic efficacy can be greatly improved by developing nanoparticulate drug delivery systems (nano-DDS) with high drug loading capacity and smart stimulus-triggered drug release in tumor cells. Herein, we report a novel redox dual-responsive prodrug-nanosystem self-assembled by hydrophobic small-molecule conjugates of paclitaxel (PTX) and oleic acid (OA). Thioether linked conjugates (PTX-S-OA) and dithioether inserted conjugates (PTX-2S-OA) are designed to respond to the redox-heterogeneity in tumor...
September 14, 2016: Nano Letters
https://www.readbyqxmd.com/read/27467397/reducing-both-pgp-overexpression-and-drug-efflux-with-anti-cancer-gold-paclitaxel-nanoconjugates
#19
Fei Li, Xiaofei Zhou, Hongyu Zhou, Jianbo Jia, Liwen Li, Shumei Zhai, Bing Yan
Repeated administrations of anti-cancer drugs to patients often induce drug resistance. P-glycoprotein (Pgp) facilitates an efficient drug efflux, preventing cellular accumulation of drugs and causing multi-drug resistance (MDR). In this study, we developed a gold-paclitaxel nanoconjugate system to overcome MDR. Gold nanoparticles (GNPs) were conjugated with β-cyclodextrin enclosing paclitaxel (PTX) molecules and PEG molecules. GNP conjugates were effectively endocytosed by both drug-sensitive human lung cancer H460 cells and Pgp-overexpressed drug-resistant H460PTX cells...
2016: PloS One
https://www.readbyqxmd.com/read/27461138/novel-targets-for-paclitaxel-nano-formulations-hopes-and-hypes-in-triple-negative-breast-cancer
#20
REVIEW
Anita K Bakrania, Bhavesh C Variya, Snehal S Patel
Triple negative breast cancer is defined as one of the utmost prevailing breast cancers worldwide, possessing an inadequate prognosis and treatment option limited to chemotherapy and radiotherapy, creating a challenge for researchers as far as developing a specific targeted therapy is concerned. The past research era has shown several promising outcomes for TNBC such as nano-formulations of the chemotherapeutic agents already used for the management of the malignant tumor. Taking a glance at paclitaxel nano formulations, it has been proven beneficial in several researches in the past decade; nevertheless its solubility is often a challenge to scientists in achieving success...
September 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
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