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Liposomal amphotericine b

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https://www.readbyqxmd.com/read/28101016/cellulitis-in-a-liver-transplant-patient-as-an-initial-manifestation-of-disseminated-cryptococcal-disease
#1
Marcos Davi Gomes de Sousa, Fred Bernardes Filho, Luís Eduardo Barros Costa Fernandes, Cássia Regina Guedes Leal, Cristiane Rocha Magalhães, Marcos Antonio Custódio Neto da Silva, Halime Silva Barcaui
A 50-year-old male underwent liver transplantation due to cryptogenic cirrhosis and was admitted with severe pain in the left leg as well as phlogosis. Amoxicillin/clavulanic acid was prescribed, assuming bullous erysipelas. Among the tests performed, the latex agglutination test for the Cryptococcus sp. antigen was positive, and in both the blood culture and blister culture Cryptococcus sp. was isolated. Daily fluconazole was started. Even though liposomal amphotericin B has been started on the fifth day of hospitalization, the patient progressed to death...
September 2016: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28099778/pseudozyma-and-other-non-candida-opportunistic-yeast-bloodstream-infections-in-a-large-stem-cell-transplant-center
#2
Anupam Pande, Lemuel R Non, Rizwan Romee, Carlos A Q Santos
INTRODUCTION: Non-Candida opportunistic yeasts are emerging causes of bloodstream infection (BSI) in immunocompromised hosts. However, their clinical presentation, management, and outcomes in stem cell transplant (SCT) recipients are not well described. CASE REPORT AND REVIEW: We report the first case to our knowledge of Pseudozyma BSI in a SCT recipient. He had evidence of cutaneous involvement, which has not been previously described in the literature. He became infected while neutropenic and receiving empiric micafungin, which is notable because Pseudozyma is reported to be resistant to echinocandins...
January 18, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28097002/ambisome-induced-avascular-necrosis-of-the-alae-of-the-nose-of-a-very-young-girl-suffering-from-kala-azar-a-case-report
#3
Shomik Maruf, Proggananda Nath, Fatima Aktar, Ariful Basher
Although liposomal amphotericin B (AmBisome) is considered as the first-line treatment for New Kala-azar, there is not enough evidence on the dosage formulation in children and its effect on them. Being considered as the safest drug for treatment of Kala-azar, this case of AmBisome-induced avascular necrosis now gives rise to the question; whether it is actually safe enough and if a dosage modification is needed in case of children. This so far, to the best of our knowledge, is the first instance of such severe adverse event due to AmBisome administration...
December 2016: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28095796/a-severe-case-of-visceral-leishmaniasis-and-liposomal-amphotericin-b-treatment-failure-in-an-immunosuppressed-patient-15%C3%A2-years-after-exposure
#4
Anna Eichenberger, Annina E Buechi, Andreas Neumayr, Chistroph Hatz, Andri Rauch, Marc Huguenot, Eva Diamantis-Karamitopoulou, Cornelia Staehelin
BACKGROUND: Visceral leishmaniasis (VL) is a protozoan disease, which is responsible for 200.000-400.000 yearly infections worldwide. If left untreated, the fatality rate can be as high as 100% within 2 years. 90% of cases occur in just six countries: India, Bangladesh, Sudan, South Sudan, Ethiopia and Brazil. It is thus a disease rarely seen by physicians in Europe or North America. We report on the fatal case of VL in an 80-year-old immunosuppressed patient who presented with a latency of over 15 years after having visited an endemic region...
January 17, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28090056/suspected-pulmonary-infection-with-trichoderma-longibrachiatum-after-allogeneic-stem-cell-transplantation
#5
Tomoaki Akagi, Chizuko Kawamura, Norio Terasawa, Kohei Yamaguchi, Kohmei Kubo
Aspergillus and Candida species are the main causative agents of invasive fungal infections in immunocompromised human hosts. However, saprophytic fungi are now increasingly being recognized as serious pathogens. Trichoderma longibrachiatum has recently been described as an emerging pathogen in immunocompromised patients. We herein report a case of isolated suspected invasive pulmonary infection with T. longibrachiatum in a 29-year-old man with severe aplastic anemia who underwent allogeneic stem cell transplantation...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28080986/clinical-implications-of-globally-emerging-azole-resistance-in-aspergillus-fumigatus
#6
REVIEW
Jacques F Meis, Anuradha Chowdhary, Johanna L Rhodes, Matthew C Fisher, Paul E Verweij
Aspergillus fungi are the cause of an array of diseases affecting humans, animals and plants. The triazole antifungal agents itraconazole, voriconazole, isavuconazole and posaconazole are treatment options against diseases caused by Aspergillus However, resistance to azoles has recently emerged as a new therapeutic challenge in six continents. Although de novo azole resistance occurs occasionally in patients during azole therapy, the main burden is the aquisition of resistance through the environment. In this setting, the evolution of resistance is attributed to the widespread use of azole-based fungicides...
December 5, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28070050/-clinical-comparative-analysis-for-pulmonary-histoplasmosis-and-progressive-disseminated-histoplasmosis
#7
Yan Zhang, Xiaoli Su, Yuanyuan Li, Ruoxi He, Chengping Hu, Pinhua Pan
To compare clinical features, diagnosis and therapeutic effect between pulmonary histoplasmosis and progressive disseminated histoplasmosis.
 Methods: A retrospective analysis for 12 cases of hospitalized patients with histoplasmosis, who was admitted in Xiangya Hospital, Central South University during the time from February 2009 to October 2015, was carried out. Four cases of pulmonary histoplasmosis and 8 cases of progressive disseminated histoplasmosis were included. The differences of clinical features, imaging tests, means for diagnosis and prognosis were analyzed between the two types of histoplasmosis...
December 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28053850/disseminated-coccidioidomycosis-presenting-with-intramedullary-spinal-cord-abscesses-management-challenges
#8
Kristina L Bajema, Mark F Dalesandro, David N Fredricks, Meena Ramchandani
Coccidioides species are endemic to the southwestern United States and typically cause a mild or asymptomatic primary infection. In some instances, infection can disseminate and involve the central nervous system with meningitis being the most common manifestation. Non-osseous spinal cord involvement is exceedingly rare. We report a case of disseminated coccidioidomycosis in an otherwise healthy 20 year old man with diffuse leptomeningeal enhancement, cerebrospinal fluid findings suggestive of meningitis, and intramedullary spinal cord abscesses...
March 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28049033/cryptococcal-infection-of-the-ventriculoperitoneal-shunt-in-an-hiv-infected-patient-with-an-excellent-immunovirological-status
#9
Miguel Genebat, María J Mayorga-Buiza, Esperanza Castillo-Ojeda, Mónica Rivero-Garvía, Francisco J Márquez-Rivas, Manuel E Jiménez-Mejías
BACKGROUND: Cryptococcus is a rare cause of ventriculoperitoneal shunt infection, with a variable clinical presentation. Hence, diagnosis and therapeutic management of this entity is challenging. CASE DESCRIPTION: we herein describe the first reported case of cryptococcal ventriculoperitoneal shunt (VPS) infection in an HIV-infected subject with an excellent immunovirological status, with an abdominal mass as the only clinical sign at presentation. Microbiological diagnosis was confirmed when Cryptococcus neoformans was isolated in 4 cerebrospinal fluid samples on different days...
December 31, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28019140/cutaneous-mucormycosis-as-result-of-insulin-administration-in-an-aml-patient-case-report-and-review-of-the-literature
#10
Anke Delie, Philip Vlummens, David Creytens, Eva Steel
We present a case of cutaneous mucormycosis in a patient with several important risk factors precipitating disease, namely underlying acute myeloid leukaemia and poorly controlled secondary diabetes. Inoculation was most likely caused by repeated minor trauma (insulin injection) at the site of infection. Treatment consisted of surgical debridement and liposomal Amphotericin B (LAmB) during 71 days. Posaconazole had already been initiated prior to infection as primary antifungal prophylaxis but was discontinued during follow-up as susceptibility testing later revealed resistance to posaconazole...
December 26, 2016: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28011960/visceral-leishmaniasis-in-immunocompromised-diagnostic-and-therapeutic-approach-and-evaluation-of-the-recently-released-idsa-guidelines
#11
Pasquale Pagliano, Tiziana Ascione, Giusy Di Flumeri, Giovanni Boccia, Francesco De Caro
Visceral Leishmaniasis (VL) is a chronic infectious disease endemic in tropical and sub-tropical areas including the Mediterranean basin, caused by a group of protozoan parasites of the genus Leishmania and transmitted by phlebotomine sandflies. Typically, VL is classified as a zoonotic infection when Leishmania infantum is the causative agent and as an anthroponotic one when L. donovani is the causative agent. Immunocompromised patients, in particular HIV positive, are considered at risk of VL. They may present atypical signs and poor response to the treatment due to a compromission of T-helper and regulatory cells activity...
1, 2016: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/28007722/physical-compatibility-of-isavuconazonium-sulfate-with-select-i-v-drugs-during-simulated-y-site-administration
#12
Wonhee So, Liz Kim, Abrar K Thabit, David P Nicolau, Joseph L Kuti
PURPOSE: The physical compatibility of isavuconazonium sulfate with 95 i.v. drugs during simulated Y-site administration was studied. METHODS: Isavuconazonium sulfate for injection and all other drugs were reconstituted according to the manufacturer's recommendation and further diluted with 0.9% sodium chloride injection or 5% dextrose injection to a final concentration (1.5 mg/mL for isavuconazonium sulfate and standard concentrations used clinically for other drugs)...
January 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27999807/clinical-and-microbiological-characteristics-of-visceral-leishmaniasis-outbreak-in-a-northern-italian-nonendemic-area-a-retrospective-observational-study
#13
E Franceschini, C Puzzolante, M Menozzi, L Rossi, A Bedini, G Orlando, W Gennari, M Meacci, G Rugna, E Carra, M Codeluppi, C Mussini
Background. Visceral leishmaniasis (VL) caused by Leishmania infantum is endemic in the Mediterranean area. In the last decades a northward spread of the parasite has been observed in Italy. This paper describes a VL outbreak in Modena province (Emilia-Romagna, Northern Italy) between 2012 and 2015. Methods. Retrospective, observational study to evaluate epidemiological, microbiological characteristics, and clinical management of VL in patients referring to Policlinico Modena Hospital. Results. Sixteen cases of VL occurred in the study period...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27995052/first-case-of-arthrographis-kalrae-fungemia-in-a-patient-with-cystic-fibrosis
#14
Julie Denis, Marcela Sabou, Tristan Degot, Ermanno Candolfi, Valérie Letscher-Bru
Arthrographis kalrae is a hyalin fungus. It is a saprophyte of the environment, mainly found in soil and compost. In recent years, cases of opportunistic infections attributed to this pathogen have been described. Our patient was a 19-year-old woman with cystic fibrosis. She presented a bacterial and fungal pulmonary colonization with Aspergillus fumigatus and Arthrographis. kalrae. After her lung transplantation, she developed an A. kalrae fungemia, treated with caspofungin 50 mg/day associated to liposomal amphotericin B i...
December 2016: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/27990355/corneal-collagen-cross-linking-and-liposomal-amphotericin-b-combination-therapy-for-fungal-keratitis-in-rabbits
#15
Zhao-Qin Hao, Jin-Xin Song, Shi-Yin Pan, Lin Zhang, Yan Cheng, Xian-Ning Liu, Jie Wu, Xiang-Hua Xiao, Wei Gao, Hai-Feng Zhu
AIM: To observe the therapeutic effect of corneal collagen cross-linking (CXL) in combination with liposomal amphotericin B in fungal corneal ulcers. METHODS: New Zealand rabbits were induced fungal corneal ulcers by scratching and randomly divided into 3 groups, i.e. control, treated with CXL, and combined therapy of CXL with 0.25% liposomal amphotericin B (n=5 each). The corneal lesions were documented with slit-lamp and confocal microscopy on 3, 7, 14, 21 and 28d after treatment...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27971701/cost-analysis-of-voriconazole-versus-liposomal-amphotericin-b-and-caspofungin-for-primary-therapy-of-invasive-aspergillosis-among-high-risk-hematologic-cancer-patients-in-lebanon
#16
G Helou, C Gao, M Xue, N Tarcha, C Charbonneau
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27970802/the-cost-of-treating-mucormycosis-with-isavuconazole-compared-with-liposomal-amphotericin-b-followed-by-posaconazole-in-the-united-kingdom-economic-evaluation-of-the-phase-iii-vital-study-and-fungiscope-matched-case-control-analysis
#17
D Kuessner, E Bagshaw, M Blackney, O A Cornely, S M Heimann, J Posthumus
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27959780/in-vitro-antifungal-susceptibilities-of-candida-species-to-liposomal-amphotericin-b-determined-using-clsi-broth-microdilution-and-amphotericin-b-deoxycholate-measured-using-the-e-test
#18
Lovero Grazia, De Giglio Osvalda, Rutigliano Serafina, Diella Giusy, Caggiano Giuseppina, Maria Teresa Montagna
The antifungal susceptibilities of 598 isolates of Candida spp. (bloodstream, other sterile sites) to liposomal amphotericin B (L-AmB) versus amphotericin B (AmB) were determined. Minimal inhibitory concentrations (MICs) were calculated using the Clinical and Laboratory Standards Institute broth microdilution (BMD; M27-A3) method for L-AmB and the E-test method for AmB. The MIC50/MIC90 (µg ml-1) values for L-AmB BMD and AmB E-test were 0.25/1 and 0.19/0.5, respectively. The overall essential agreement (± 2 dilutions) was 91...
December 13, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27932432/fungal-mobile-mass-on-echocardiogram-native-mitral-valve-aspergillus-fumigatus-endocarditis
#19
Rymon Rofaiel, Yosra Turkistani, David McCarty, Seyed M Hosseini-Moghaddam
The most common type of infective endocarditis is bacterial endocarditis. However, fungal infections have been seen more frequently, mostly in the immunocompromised population. We report a case of invasive Aspergillus fumigatus native mitral valve endocarditis. The patient received appropriate empiric antifungal treatment with a combination of liposomal amphotericin B and flucytosine, associated with surgical debridement, valve replacement and chordae tendineae repair. Despite receiving the standard treatment of Aspergillus endocarditis, and susceptibility of the microorganism to the antifungal regimen, the patient, unexpectedly, developed early-onset septic emboli...
December 8, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27917735/top-1-of-inpatients-administered-antimicrobial-agents-comprising-50-of-expenditures-a-descriptive-study-and-opportunities-for-stewardship-intervention
#20
Jennifer Dela-Pena, Luiza Kerstenetzky, Lucas Schulz, Ron Kendall, Alexander Lepak, Barry Fox
OBJECTIVE To characterize the top 1% of inpatients who contributed to the 6-month antimicrobial budget in a tertiary, academic medical center and identify cost-effective intervention opportunities targeting high-cost antimicrobial utilization. DESIGN Retrospective cohort study. PATIENTS Top 1% of the antimicrobial budget from July 1 through December 31, 2014. METHODS Patients were identified through a pharmacy billing database. Baseline characteristics were collected through a retrospective medical chart review...
December 5, 2016: Infection Control and Hospital Epidemiology
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