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Liposomal amphotericine b

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https://www.readbyqxmd.com/read/29623159/diagnosing-ring-enhancing-lesions-in-the-brain-of-a-patient-with-aids-without-brain-biopsy-a-case-of-central-nervous-system-histoplasmoma
#1
Rachel Beekman, Jessica M Hu, Steven I Aronin, Maricar F Malinis
We report a case of a Puerto Rican male with advanced AIDS who presented with multiple falls and pancytopenia. Magnetic resonance imaging (MRI) of the brain, as initial workup, revealed 2 ring-enhancing brain lesions. Initial cerebrospinal fluid analysis revealed minimal cells, mildly elevated protein, and no organism seen on gram stain. Due to prohibitive thrombocytopenia, brain biopsy was deferred. He had neither clinical nor radiographic improvement despite empiric therapy for both toxoplasmosis and bacterial abscesses...
April 2018: Neurohospitalist
https://www.readbyqxmd.com/read/29607918/-a-case-of-histoplasmosis-with-chronic-basilar-meningitis-diagnosed-relatively-early
#2
Asako Onda, Shinji Miyagawa, Taku Gomi, Tetuya Horino, Katuhiko Kamei, Hiroshi Yaguchi
A 41-year-old man left for Mexico in May 2015. Right pulmonary nodule was detected at a health examination in May 2016, and he subsequently showed headache and slight fever. Contrast-enhanced magnetic resonance imaging of the brain revealed basilar meningitis, so he was admitted to our hospital. We considered imported mycosis due to his travel history to Mexico. We diagnosed histoplasmosis based on the presence of antibodies against Histoplasma in both serum and cerebrospinal fluid. Symptoms almost completely recovered with a liposomal formulation of amphotericin B...
March 31, 2018: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29602478/-post-traumatic-pulmonary-aspergilloma
#3
M Isnard, E Hullo, Y Robert, C Piolat, C Durand, S Lantuejoul, C Garnaud, I Pin
INTRODUCTION: Aspergillomas occur due to colonization of a pre-existing pulmonary, bronchial or pleural cavity by Aspergillus spp. Often asymptomatic, this pathology can reveal itself by recurrent haemoptysis or when bacterial superinfections occur. Aspergillomas occurring in post-traumatic cavities are rare and their management is poorly codified. CASE REPORT: A child suffered from a chest wound at the age of 13 years. Two years later, investigation of recurrent haemoptysis revealed a residual pneumatocele in the right lower lobe colonized by Aspergillus spp...
March 27, 2018: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29599641/large-solitary-pulmonary-cryptococcoma-mimicking-lung-carcinoma-in-an-immunocompetent-patient
#4
Karan Manoj Anandpara, Yashant Aswani, Priya Hira
Cryptococcosis is a life-threatening mycosis typically seen in immunocompromised patients. Pulmonary cryptococcosis generally presents as multiple or solitary nodular opacities. Cryptococcal infection presenting as a destructing cavernoma (cryptococcoma) without diffuse infiltration of the lung is an extremely rare presentation, even in immunocompromised patients. This report presents a healthy, HIV negative, immunocompetent patient who presented with a large solitary lung mass provisionally diagnosed as a lung malignancy on radiological imaging that proved to be a large cryptococcoma after biopsy...
February 2018: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/29596219/efficacy-and-safety-of-echinocandins-for-the-treatment-of-invasive-candidiasis-in-children-a-meta-analysis
#5
Magdalini Tsekoura, Maria Ioannidou, Zoi-Dorothea Pana, Anna-Bettina Haidich, Charalampos Antachopoulos, Elias Iosifidis, George Kolios, Emmanuel Roilides
BACKGROUND: Echinocandins are recommended for the treatment of suspected or confirmed invasive candidiasis (IC) in adults. Less is known about the use of echinocandins for the management of IC in children. The aim of this study was to investigate the overall efficacy and safety of echinocandin class in neonatal and pediatric patients with IC. METHODS: PubMed, Cochrane Central, Scopus and Clinical trial registries were searched up to July 27, 2017. Eligible studies were randomized trials (RCTs) that evaluated the efficacy and safety of any echinocandin versus agents of other antifungal classes for the treatment of IC in pediatric patients...
March 24, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29595679/central-nervous-system-histoplasmosis-multicenter-retrospective-study-on-clinical-features-diagnostic-approach-and-outcome-of-treatment
#6
Joseph Wheat, Thein Myint, Ying Guo, Phebe Kemmer, Chadi Hage, Colin Terry, Marwan M Azar, James Riddell, Peter Ender, Sharon Chen, Kareem Shehab, Kerry Cleveland, Eden Esguerra, James Johnson, Patty Wright, Vanja Douglas, Pascalis Vergidis, Winnie Ooi, John Baddley, David Bamberger, Raed Khairy, Holenarasipur Vikram, Elizabeth Jenny-Avital, Geetha Sivasubramanian, Karen Bowlware, Barbara Pahud, Juan Sarria, Townson Tsai, Maha Assi, Satish Mocherla, Vidhya Prakash, David Allen, Catherine Passaretti, Shirish Huprikar, Albert Anderson
Central nervous system (CNS) involvement occurs in 5 to 10% of individuals with disseminated histoplasmosis. Most experience has been derived from small single center case series, or case report literature reviews. Therefore, a larger study of central nervous system (CNS) histoplasmosis is needed in order to guide the approach to diagnosis, and treatment.A convenience sample of 77 patients with histoplasmosis infection of the CNS was evaluated. Data was collected that focused on recognition of infection, diagnostic techniques, and outcomes of treatment...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29582737/case-report-diffuse-cutaneous-leishmaniasis-by-leishmania-infantum-in-a-patient-undergoing-immunosuppressive-therapy-risk-status-in-an-endemic-mediterranean-area
#7
Ma Magdalena Alcover, Vicenç Rocamora, Ma Carmen Guillén, Diana Berenguer, Marta Cuadrado, Cristina Riera, Roser Fisa
This case report highlights the risk of severe cutaneous leishmaniasis (CL) by Leishmania infantum in patients undergoing immunosuppressant therapy who either live in an endemic area or are visiting in the transmission season. The case patient, resident in Majorca (Balearic Islands), presented 12 disseminated erythematous skin lesions, 1-6 cm in diameter, located on the scalp, cheek, umbilical region, and lower extremities 8 years after undergoing anti-tumor necrosis factor (TNF) therapy. Parasite presence in peripheral blood and high levels of specific antibodies were also observed, indicating a possible risk of CL shifting toward a visceral infection...
March 26, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29579858/visceral-leishmaniasis-in-renal-transplant-recipients-report-of-2-cases
#8
F Clavijo Sánchez, T Vázquez Sánchez, M Cabello Díaz, V E Sola Moyano, C Jironada Gallego, D Hernández Marrero
Visceral leishmaniasis is a disease caused by the protozoan Leishmania and is transmitted by Lutzomyia longipalpis (sand fly). It is an endemic parasitic infection in numerous areas around the Mediterranean basin. Though immunocompetent patients may not develop the disease, in transplant recipients the use of corticoids and intensified immunosuppressants to prevent graft rejection may accelerate the disease, causing severe damage to the liver, spleen, and hematopoietic system. We report 2 cases of visceral leishmaniasis with an atypical presentation in transplant recipients...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29573830/gastric-mucormycosis-in-a-liver-and-kidney-transplant-recipient-case-report-and-concise-review-of-literature
#9
G Alfano, F Fontana, D Francesca, G Assirati, P Magistri, G Tarantino, R Ballarin, G Rossi, E Franceschini, M Codeluppi, G Guaraldi, C Mussini, F Di Benedetto, G Cappelli
Mucormycosis is an uncommonly encountered fungal infection in solid organ transplantation. The infection is severe and often results in a fatal outcome. The most common presentations are rhino-sino-orbital and pulmonary disease. We describe a rare case of gastric mucormycosis in a patient with a combined liver-kidney transplant affected by glycogen storage disease type Ia. A 42-year-old female patient presented with gastric pain and melena 26 days after transplantation. Evaluation with upper endoscopy showed two bleeding gastric ulcers...
March 22, 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29554829/prolonged-voriconazole-treatment-in-a-patient-with-chronic-lymphocytic-leukemia-resulting-in-a-litany-of-chronic-overlapping-toxicities
#10
Caitlin R Rausch, Dimitrios P Kontoyiannis
Voriconazole is a triazole antifungal with activity against a number of yeast and mold species including Candida, Aspergillosis, Fusarium, and Coccidioides. Invasive fungal infections are associated with high morbidity and mortality, prolonged treatment courses, and occasionally lifelong suppressive therapy. Voriconazole therapy can result in a number of acute toxicities that clinicians are frequently aware of including hepatotoxicity, visual disturbances, and hallucinations; however, there is limited experience with extended durations of voriconazole therapy...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29554244/safety-and-effectiveness-of-short-course-ambisome-in-the-treatment-of-post-kala-azar-dermal-leishmaniasis-pkdl-a-prospective-cohort-study-in-bangladesh
#11
Margriet den Boer, Asish Kumar Das, Fatima Akhter, Sakib Burza, V Ramesh, Be-Nazir Ahmed, Eduard E Zijlstra, Koert Ritmeijer
Background: A safe and effective short-course treatment regimen for Post Kala Azar Dermal Leishmaniasis (PKDL) is considered essential for achieving and sustaining elimination of visceral leishmaniasis (VL) in the Indian subcontinent.(1, 2) Here, single dose liposomal amphotericin B (AmBisome) has been adopted as a first line regimen for VL; however the effectiveness and safety of AmBisome for PKDL has not been formally evaluated. Methods: The safety and effectiveness of AmBisome 15 mg/kg, given over 15 days in 5 biweekly infusions of 3mg/kg on an outpatient basis, was evaluated between April and November 2014 in clinically diagnosed PKDL patients of 12 years and older residing in a highly VL endemic area in Bangladesh...
March 15, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29550282/liposomal-amphotericin-b-treatment-of-old-world-cutaneous-and-mucosal-leishmaniasis-a-literature-review
#12
REVIEW
Vincent Mosimann, Andreas Neumayr, Daniel H Paris, Johannes Blum
Old World cutaneous and mucosal leishmaniasis is a potentially serious disease. Systemic treatment approaches with pentavalent antimonials, liposomal amphotericin B, fluconazole and miltefosine are increasingly used despite the absence of supportive evidence - to date, no prospective clinical trials have been conducted for systemic treatment of these diseases. We performed a literature search to delineate the contemporary evidence for the use of liposomal amphotericin B, and found that although cure rates of 17/20 (85%) were achieved in immune competent patients with Old World cutaneous leishmaniasis and cure rates of 10/13 (77%) for Old World mucosal leishmaniasis due to L...
June 2018: Acta Tropica
https://www.readbyqxmd.com/read/29544767/diagnosis-and-management-of-aspergillus-diseases-executive-summary-of-the-2017-escmid-ecmm-ers-guideline
#13
A J Ullmann, J M Aguado, S Arikan-Akdagli, D W Denning, A H Groll, K Lagrou, C Lass-Flörl, R E Lewis, P Munoz, P E Verweij, A Warris, F Ader, M Akova, M C Arendrup, R A Barnes, C Beigelman-Aubry, S Blot, E Bouza, R J M Brüggemann, D Buchheidt, J Cadranel, E Castagnola, A Chakrabarti, M Cuenca-Estrella, G Dimopoulos, J Fortun, J-P Gangneux, J Garbino, W J Heinz, R Herbrecht, C P Heussel, C C Kibbler, N Klimko, B J Kullberg, C Lange, T Lehrnbecher, J Löffler, O Lortholary, J Maertens, O Marchetti, J F Meis, L Pagano, P Ribaud, M Richardson, E Roilides, M Ruhnke, M Sanguinetti, D C Sheppard, J Sinkó, A Skiada, M J G T Vehreschild, C Viscoli, O A Cornely
The European Society for Clinical Microbiology and Infectious Diseases, the European Confederation of Medical Mycology and the European Respiratory Society Joint Clinical Guidelines focus on diagnosis and management of aspergillosis. Of the numerous recommendations, a few are summarized here. Chest computed tomography as well as bronchoscopy with bronchoalveolar lavage (BAL) in patients with suspicion of pulmonary invasive aspergillosis (IA) are strongly recommended. For diagnosis, direct microscopy, preferably using optical brighteners, histopathology and culture are strongly recommended...
March 12, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29538730/challenges-in-the-diagnosis-and-treatment-of-mucormycosis
#14
A Skiada, C Lass-Floerl, N Klimko, A Ibrahim, E Roilides, G Petrikkos
The diagnosis and treatment of mucormycosis are challenging. The incidence of the disease seems to be increasing. Hematological malignancies are the most common underlying disease in countries with high income and uncontrolled diabetes in developing countries. Clinical approach to diagnosis lacks sensitivity and specificity. Radiologically, multiple (≥10) nodules and pleural effusion are reportedly associated with pulmonary mucormycosis. Another finding on computerized tomography (CT) scan, which seems to indicate the presence of mucormycosis, is the reverse halo sign...
April 1, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29538509/visceral-leishmaniasis-in-a-brazilian-endemic-area-an-overview-of-occurrence-hiv-coinfection-and-lethality
#15
João Gabriel Guimarães Luz, Danilo Bueno Naves, Amanda Gabriela de Carvalho, Gilvani Alves Meira, João Victor Leite Dias, Cor Jesus Fernandes Fontes
The Brazilian municipality of Rondonópolis, Mato Grosso State, represents an important visceral leishmaniasis (VL) endemic area. This study described epidemiological and clinical aspects of the occurrence, VL/HIV coinfection and lethality related to VL in Rondonópolis. Data from autochthonous cases reported between 2011 and 2016 were obtained from official information systems. During this period, 81 autochthonous cases were reported, with decreasing incidence through 2016. Contrastingly, the lethality rate was 8...
March 8, 2018: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/29526942/successful-treatment-of-intestinal-mycosis-caused-by-a-simultaneous-infection-with-lichtheimia-ramosa-and-aspergillus-calidoustus
#16
Yukihiro Kaneko, Ken-Ichi Oinuma, Tsuneko Terachi, Yasuaki Arimura, Mamiko Niki, Koichi Yamada, Hiroshi Kakeya, Tetsu Mizutani
A 53-year-old woman was hospitalized due to septic shock after developing pneumococcal pneumonia after undergoing esophageal cancer surgery. Her transverse colon became perforated after receiving antimicrobial chemotherapy; therefore, emergency subtotal colectomy was performed. Fungi detected in both her colon tissue and a drainage sample indicated intestinal mucormycosis. Early intensive treatment with high-dose liposomal amphotericin B was successful, and she was subsequently discharged from the hospital...
March 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29525621/lipid-mediated-mode-of-action-of-local-anesthetics-on-lipid-pores-induced-by-polyenes-peptides-and-lipopeptides
#17
Svetlana S Efimova, Evgeny G Chulkov, Olga S Ostroumova
The effects of local anesthetics (LAs), namely, lidocaine (LDC), prilocaine (PLC), mepivacaine (MPV), bupivacaine (BPV), procaine (PC), and tetracaine (TTC), on the steady-state transmembrane conductance induced by the cis-side addition of the antifungal polyene macrolide antibiotic, nystatin (NYS), in planar lipid bilayers were studied. The addition of TTC to model membranes comprising DOPC and cholesterol (33 mol%) led to a nearly twenty-fold increase in the steady-state NYS-induced membrane conductance...
March 8, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29451812/efficacy-of-nebulized-liposomal-amphotericin-b-in-the-treatment-of-abpa-in-an-hiv-hbv-co-infected-man-case-report-and-literature-review
#18
Magali Garcia, Gwénaël Le Moal, Jacques Cadranel, France Roblot, Cendrine Godet
No abstract text is available yet for this article.
February 16, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29438132/successful-combination-therapy-of-liposomal-amphotericin-b-and-caspofungin-for-disseminated-fusariosis-in-a-pediatric-patient-with-acute-lymphoblastic-leukemia
#19
Suguru Uemura, Akihiro Tamura, Nobuyuki Yamamoto, Atsuro Saito, Sayaka Nakamura, Takahiro Fujiwara, Teppei Tahara, Aiko Kozaki, Kenji Kishimoto, Toshiaki Ishida, Daiichiro Hasegawa, Yasunori Muraosa, Katsuhiko Kamei, Yoshiyuki Kosaka
Disseminated fusariosis is a fatal infection in immunocompromised hosts. However, the optimal antifungal treatment for disseminated fusariosis has not yet been established. We report a case of disseminated fusariosis after chemotherapy for acute lymphoblastic leukemia, presenting with multiple skin, lung, and kidney lesions and cerebrospinal fluid invasion. The combination therapy of liposomal amphotericin B and caspofungin resolved disseminated fusariosis successfully.
February 12, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29424815/successful-treatment-of-disseminated-cutaneous-leishmaniasis-with-liposomal-amphotericin-b-and-miltefosine-in-an-eight-year-old-girl
#20
Seyedeh Sedigheh Hamzavi, Anahita Sanaei Dashti, Mohammad Rahim Kadivar, Gholamreza Pouladfar, Bahman Pourabbas
This case report presents an 8-year-old girl, from Fars province in Iran, diagnosed with cutaneous leishmaniasis in the form of multiple nodular, ulcerative and crusted lesions disseminated on the face, trunk and extremities. The result of direct smear of ulcers was positive for Leishmania parasite. The patient had no immunodeficiency or relevant family history making her susceptible for disseminated cutaneous leishmaniasis. The skin lesions failed to respond to multiple treatment courses of meglumine antimoniate or amphotericin B but were successfully treated with simultaneous miltefosine and liposomal amphotericin B...
March 2018: Pediatric Infectious Disease Journal
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