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Liposomal amphotericine b

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https://www.readbyqxmd.com/read/29218389/primary-prophylaxis-of-invasive-fungal-infections-in-patients-with-haematological-malignancies-2017-update-of-the-recommendations-of-the-infectious-diseases-working-party-agiho-of-the-german-society-for-haematology-and-medical-oncology-dgho
#1
REVIEW
Sibylle C Mellinghoff, Jens Panse, Nael Alakel, Gerhard Behre, Dieter Buchheidt, Maximilian Christopeit, Justin Hasenkamp, Michael Kiehl, Michael Koldehoff, Stefan W Krause, Nicola Lehners, Marie von Lilienfeld-Toal, Annika Y Löhnert, Georg Maschmeyer, Daniel Teschner, Andrew J Ullmann, Olaf Penack, Markus Ruhnke, Karin Mayer, Helmut Ostermann, Hans-H Wolf, Oliver A Cornely
Immunocompromised patients are at high risk of invasive fungal infections (IFI), in particular those with haematological malignancies undergoing remission-induction chemotherapy for acute myeloid leukaemia (AML) or myelodysplastic syndrome (MDS) and recipients of allogeneic haematopoietic stem cell transplants (HSCT). Despite the development of new treatment options in the past decades, IFI remains a concern due to substantial morbidity and mortality in these patient populations. In addition, the increasing use of new immune modulating drugs in cancer therapy has opened an entirely new spectrum of at risk periods...
December 7, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/29215329/chemotherapeutics-of-visceral-leishmaniasis-present-and-future-developments
#2
Shyam Sundar, Anup Singh
Treatment of Visceral Leishmaniasis (VL), a neglected tropical disease, is very challenging with few treatment options. Long duration of treatment and drug toxicity further limit the target of achieving VL elimination. Chemotherapy remains the treatment of choice. Single dose of liposomal amphotericin B (LAmB) and multidrug therapy (LAmB + miltefosine, LAmB + paromomycin (PM), or miltefosine + PM) are recommended treatment regimen for treatment of VL in Indian sub-continent. Combination therapy of pentavalent antimonials (Sbv) and PM in East Africa and LAmB in the Mediterranean region/South America remains the treatment of choice...
December 7, 2017: Parasitology
https://www.readbyqxmd.com/read/29213345/the-management-of-chronic-pulmonary-aspergillosis-the-uk-national-aspergillosis-centre-approach
#3
REVIEW
Firas Maghrabi, David W Denning
Purpose of Review: Chronic pulmonary aspergillosis (CPA) is a serious long-term fungal disease of the lung with a worldwide prevalence. Treatment of CPA is not straightforward given the often-multiple associated co-morbidities, complex clinical picture, drug interactions, toxicities and intolerances. Recent Findings: First line treatment is oral itraconazole or voriconazole. In the event of intolerance or toxicity, patients may be swapped from itraconazole to voriconazole or vice versa...
2017: Current Fungal Infection Reports
https://www.readbyqxmd.com/read/29203252/occurrence-and-improvement-of-renal-dysfunction-and-serum-potassium-abnormality-during-administration-of-liposomal-amphotericin-b-in-patients-with-hematological-disorders-a-retrospective-analysis
#4
Hiroyuki Yamazaki, Tadakazu Kondo, Kazunai Aoki, Kouhei Yamashita, Akifumi Takaori-Kondo
Liposomal amphotericin B (L-AMB) has the potential to cause two major adverse events, renal dysfunction and serum potassium abnormality; however, appropriate clinical management of these events remains unclear. We retrospectively analyzed data regarding 128 hematology patients who received L-AMB in our institute and examined the association between clinical characteristics and renal dysfunction or serum potassium abnormality. We found that the median weight-normalized dose of L-AMB was 2.69mg/kg and the median administration period was 16days...
November 7, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29194382/liposomal-and-deoxycholate-amphotericin-b-formulations-effectiveness-against-biofilm-infections-of-candida-spp
#5
Célia F Rodrigues, Mariana Henriques
BACKGROUND: candidiasis is the primary fungal infection encountered in patients undergoing prolonged hospitalization, and the fourth leading cause of nosocomial bloodstream infections. One of the most important Candida spp. virulence factors is the ability to form biofilms, which are extremely refractory to antimicrobial therapy and very difficult to treat with the traditional antifungal therapies. It is known that the prophylaxis or treatment of a systemic candidiasis are recurrently taken without considering the possibility of a Candida spp...
December 1, 2017: Pathogens
https://www.readbyqxmd.com/read/29188178/tumor-shape-pulmonary-mucormycosis-associated-with-sinonasal-aspergillosis-in-a-diabetic-patient
#6
Sophie Point, Frédéric Gabriel, Hugues Bégueret, Jacques Jougon, Fanny Lanternier, Frédéric Grenouillet, Manal Abdel Fattah, Emilie Catherinot, Chantal Raherison, Elodie Blanchard
Mucormycosis is a rare and life-threatening fungal infection of the Mucorales order occurring mainly in immunosuppressed patients. The most common forms are rhinocerebral but pulmonary or disseminated forms may occur. We report the case of a 61-year-old patient in whom pulmonary mucormycosis was diagnosed during his first-ever episode of diabetic ketoacidosis. While receiving liposomal amphotericin B, a sinusal aspergillosis due to Aspergillus fumigatus occurred. Evolution was slowly favorable under antifungal tritherapy by liposomal amphotericin B, posaconazole and caspofungin...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29165590/miltefosine-resistant-leishmania-infantum-strains-with-an-impaired-mt-ros3-transporter-complex-retain-amphotericin-b-susceptibility
#7
Annelies Mondelaers, Sarah Hendrickx, Lieselotte Van Bockstal, Louis Maes, Guy Caljon
Objectives: Increasing numbers of miltefosine treatment failures in visceral leishmaniasis therapy and reports of miltefosine resistance in the Indian subcontinent resulted in the recommendation to use liposomal amphotericin B as first-line therapy. Cross-resistance between miltefosine and amphotericin B has recently been documented, suggesting a role of mutations in the miltefosine transporter, a complex encoded by the MT and ROS3 genes. This study aimed to further explore the putative role of MT/ROS3 defects in the molecular basis of amphotericin B cross-resistance...
November 18, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29155816/liposomal-amphotericin-b-in-travelers-with-cutaneous-and-muco-cutaneous-leishmaniasis-not-a-panacea
#8
Romain Guery, Benoit Henry, Guillaume Martin-Blondel, Claire Rouzaud, Florence Cordoliani, Gundel Harms, Jean-Pierre Gangneux, Françoise Foulet, Emmanuelle Bourrat, Michel Baccard, Gloria Morizot, Paul-Henri Consigny, Antoine Berry, Johannes Blum, Olivier Lortholary, Pierre Buffet
BACKGROUND: Complex cutaneous and muco-cutaneous leishmaniasis (CL and MCL) often requires systemic therapy. Liposomal amphotericin B (L-AmB) has a strong potential for a solid clinical benefit in this indication. METHODS: We conducted a retrospective analysis of data from a French centralized referral treatment program and from the "LeishMan" European consortium database. All patients with parasitologically proven CL or MCL who received at least one dose of L-AmB were included...
November 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29151329/epidemiology-and-analysis-of-invasive-fungal-infections-in-patients-withhematological-malignancies-a-single-center-real-life-experience
#9
Nur Soyer, Hatice Demet Kiper Ünal, Filiz Vural, Fahri Şahin, Mahmut Töbü, Ayhan Dönmez, Murat Tombuloğlu, Bilgin Arda, Güray Saydam
Background/aim: Invasive fungal infection (IFI) causes morbidity and mortality among patients with hematological malignancies. We evaluated the incidence and treatment characteristics of IFIs between October 2012 and December 2013. Materials and methods: Patients who received chemotherapy or stem cell transplantation were retrospectively evaluated. Fungal infections were classified according to EORTC criteria.Results: Prophylaxis and antifungal therapy were given in 30.5% and 23.6% of 522 chemotherapy courses, respectively...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29138100/amphotericin-b-for-treatment-of-visceral-leishmaniasis-a-systematic-review-and-meta-analysis-of-prospective-comparative-clinical-studies-including-dose-ranging-studies
#10
REVIEW
Chaturaka Rodrigo, Praveen Weeratunga, Sumadhya Deepika Fernando, Senaka Rajapakse
OBJECTIVES: The aim of this review is to evaluate the evidence for use of different formulations of amphotericin B, minimum effective dose for each formulation and its comparative efficacy against other drugs in achieving definitive cure of visceral leishmaniasis. METHODS: This systematic review and meta-analysis included following data sources; PubMed, EMBASE, Scopus, Web of Science and CINAHL. Controlled prospective clinical trials (randomized or non-randomized, including dose ranging studies) conducted between 1996 and 2017, with at least one treatment group receiving amphotericin B were included (published data only)...
November 11, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29125646/epidural-abscess-caused-by-schizophyllum-commune-a-rare-case-of-rhinogenic-cranial-complication-by-a-filamentous-basidiomycete
#11
Kazuya Tone, Ryuichi Fujisaki, Shigehiro Hagiwara, Takashi Tamura, Shinobu Ishigaki, Mohamed Mahdi Alshahni, Makoto Takehisa, Takehiro Watanabe, Takuya Yasui, Takuo Tokairin, Toshiyo Sagawa, Tetsuya Sakamoto, Ken Ito, Kazuyoshi Kuwano, Koichi Makimura
Central nervous system (CNS) infections due to filamentous basidiomycetes are extremely rare. We encountered a case of epidural abscess due to Schizophyllum commune that extended from sinusitis. A 53-year-old Japanese man presented at our hospital with a headache. Computed tomography (CT) of the cranium and sinuses showed ethmoid and sphenoid sinusitis with no intracranial abnormalities. The patient was diagnosed with acute sinusitis and underwent antibiotic treatment. However, the symptoms deteriorated, and the patient came to our hospital again with consciousness disturbance...
November 10, 2017: Mycoses
https://www.readbyqxmd.com/read/29123908/a-case-of-disseminated-cryptococcosis-with-necrotizing-fasciitis-in-a-non-hiv-patient
#12
Tetsuya Hoshino, Kazuya Omura, Shinichi Kimura, Hiroyuki Takahashi, Katsuhiko Kamei, Misako Ohkusu
Case: Disseminated cryptococcosis is a well-recognized condition among HIV patients, but it also occurs in non-HIV patients. Necrotizing fasciitis caused by cryptococcus is rare. An 81-year-old man who had received steroid therapy presented with erythema and pain in his right thigh. After the rapid progression of symptoms and a failure to respond to antibiotic therapy, a clinical diagnosis of necrotizing fasciitis was made. We performed debridement, and yeasts were detected using a Gram stain of the fascia...
October 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29119669/sinusitis-caused-by-exserohilum-rostratum-after-cord-blood-transplantation-for-myelodysplastic-syndrome-a-case-report-and-literature-review
#13
Sumiko Kohashi, Takaaki Toyama, Norisato Hashimoto, Masatoshi Sakurai, Jun Kato, Taku Kikuchi, Yuya Koda, Kayoko Sugita, Naoki Hasegawa, Kyoko Yarita, Katsuhiko Kamei, Shinichiro Okamoto, Takehiko Mori
Invasive fungal disease is a serious infectious complication of allogeneic hematopoietic stem cell transplantation (HSCT). Exserohilum rostratum is a species causing phaeohyphomycosis, which rarely causes invasive disease in humans. We treated a case of sinusitis caused by E. rostratum after cord blood transplantation (CBT). A 60-year-old man with myelodysplastic syndrome, who had a medical history of an operation to correct deviation of the nasal septum, developed sinusitis caused by E. rostratum under prolonged profound neutropenia after a second CBT because of the graft rejection of the first transplantation...
November 8, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29112326/real-world-challenges-and-unmet-needs-in-the-diagnosis-and-treatment-of-suspected-invasive-pulmonary-aspergillosis-in-patients-with-hematological-diseases-an-illustrative-case-study
#14
Martin Hoenigl, Juergen Prattes, Peter Neumeister, Albert Wölfler, Robert Krause
Recent years have seen important advances in the diagnosis of invasive pulmonary aspergillosis (IPA), complemented by the introduction of new therapies. Despite this, IPA remains a major cause of infection-related mortality in patients with hematological diseases. There are two main reasons for this. First, diagnosis of IPA remains a challenge, since risk factors and the clinical, radiological and mycological presentations vary not only by fungal disease stage, but also by patient group (e.g. neutropenic versus non-neutropenic patients)...
November 7, 2017: Mycoses
https://www.readbyqxmd.com/read/29109372/marine-algae-as-source-of-novel-antileishmanial-drugs-a-review
#15
REVIEW
Lauve Rachel Tchokouaha Yamthe, Regina Appiah-Opong, Patrick Valere Tsouh Fokou, Nole Tsabang, Fabrice Fekam Boyom, Alexander Kwadwo Nyarko, Michael David Wilson
Leishmaniasis is a vector-borne neglected tropical disease caused by protozoan parasites of the Leishmania genus and transmitted by the female Phlebotomus and Lutzomyia sand flies. The currently prescribed therapies still rely on pentavalent antimonials, pentamidine, paromomycin, liposomal amphotericin B, and miltefosine. However, their low efficacy, long-course treatment regimen, high toxicity, adverse side effects, induction of parasite resistance and high cost require the need for better drugs given that antileishmanial vaccines may not be available in the near future...
October 29, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29102349/bilateral-candida-endophthalmitis-accompanying-candida-lusitaniae-bloodstream-infection-a-case-report
#16
Shinya Yamamoto, Mahoko Ikeda, Fumie Fujimoto, Koh Okamoto, Yoshitaka Wakabayashi, Tomoaki Sato, Keita Tatsuno, Toshikatsu Kaburaki, Shuntaro Yoshida, Shu Okugawa, Kazuhiko Koike, Kyoji Moriya
Candida lusitaniae is an uncommon cause of candidiasis in humans. Ocular manifestations of C. lusitaniae infection have not been reported. C. lusitaniae is either intrinsically resistant to amphotericin B or can acquire such resistance. We describe a case of bilateral endophthalmitis due to C. lusitaniae bloodstream infection in a liver transplant patient with rectal cancer. The patient suffered fungemia and endophthalmitis and was treated with liposomal amphotericin B. The isolate was identified as C. lusitaniae by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, the system based on biochemical tests, and sequencing of the internal transcribed spacer region...
October 25, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29102310/-vertebral-osteomyelitis-due-to-candida-tropicalis-secondary-to-candidemia-a-case-report
#17
S Zayet, I Chaabane, B Kilani, M Bouaziz, F Ladeb, H B Tiouiri
Candida spp. vertebral osteomyelitis is rare. Clinical presentation is unspecific. Diagnosis requires mycological culture of a biopsy specimen. Therapeutic management is based on prolonged course of azole or liposomal amphotericin B. We report the case of Candida tropicalis vertebral osteomyelitis with epidural involvement in a 27 years-old male patient, followed for S-β-thalassemia and with a history of candidemia. The fungus was isolated from a needle biopsy of the vertebral disk. The outcome was favorable under antifungal treatment by amphotericin B and voriconazole...
October 25, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29078022/cost-effectiveness-of-liposomal-amphotericin-b-in-hospitalized-patients-with-mucocutaneous-leishmaniasis
#18
Sóstenes Mistro, Bárbara Gomes, Lorena Rosa, Ligia Miranda, Marianne Camargo, Roberto Badaró
OBJECTIVE: To compare the cost-effectiveness of L-AmB with that of SbV and AmB-D, for the treatment of mucocutaneous leishmaniasis in a hospital in northeast Brazil. METHODS: We developed an economic model based on retrospective data of 73 hospitalized patients in 2006-2012, from hospital and public health system perspectives. RESULTS: In the economic model, 82.2% of patients who started treatment with L-AmB had completed it after 2 months, versus 22...
October 27, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29077791/prosthetic-valve-candida-spp-endocarditis-new-insights-into-long-term-prognosis-the-escape-study
#19
Claire Rivoisy, Antonio Vena, Laura Schaeffer, Caroline Charlier, Arnaud Fontanet, François Delahaye, Emilio Bouza, Olivier Lortholary, Patricia Munoz, Agnès Lefort
Background: Prosthetic valve endocarditis caused by Candida spp. (PVE-C) is rare and devastating, with international guidelines based on expert recommendations consisting in the combination of surgery and subsequent azole treatment. Methods: PVE-C collected in Spain and France between 2001 and 2015 were retrospectively analyzed with a focus on management and outcome. Results: Forty-six cases were followed up for a median of 9 months. Twenty-two (48%) patients had a past history of endocarditis; 30 (65%) cases were nosocomial or healthcare-related, 9 (20%) patients were intravenous drug users...
October 25, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29071205/disseminated-paracoccidioidomycosis-prediagnosticated-as-neoplasm-an-important-challenge-in-diagnosis-using-rt-pcr
#20
Fabiana Rocha-Silva, Cássio Ferreira Guimarães, Edmundo Rocha de Oliveira Júnior, Sônia Maria de Figueiredo, Rachel Basques Caligiorne
This paper presents a case of disseminated paracoccidioidomycosis in a 62-year-old male patient, who lives in Belo Horizonte, MG, Brazil. The patient was hospitalized with icteric syndrome of cholestatic pattern and weight loss, with loss 30 kg in 5 months. The imaging of the abdomen showed lesion of infiltrative pattern, affecting gallbladder and intrahepatic bile ducts, suggesting neoplasia of malignant behavior, besides to presenting the yellow nail syndrome. Dermatological examination presented erythematous-infiltrated plaques in the occipital region...
March 2018: Medical Mycology Case Reports
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