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https://www.readbyqxmd.com/read/27888916/refractory-chronic-rhinosinusitis-with-nasal-polyposis
#1
REVIEW
Benjamin P Hull, Rakesh K Chandra
Chronic rhinosinusitis with nasal polyposis (CRSwNP) represents a subset of chronic sinusitis with various causes. Some forms of the disease are driven by allergy, often in association with asthma. Refractory CRSwNP can be associated with cystic fibrosis and other clinical syndromes. More recent literature is presented regarding roles of innate immunity and superantigens. Effective treatment of CRSwNP requires careful endoscopic sinus surgery followed by an individualized treatment plan that often includes oral and topical steroids...
February 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/27876251/-food-protein-induced-enterocolitis-syndrome-a-case-report-of-diarrhea-with-hypovolemic-shock-and-methemoglobinemia
#2
L Genere, N Pecciarini, N Peretti, F Villard, A Lachaux
We report on the case of a young infant with chronic diarrhea that worsened and turned into hypovolemic shock with methemoglobinemia. We underline and discuss the main features of food protein-induced enterocolitis syndrome (FPIES). FPIES is a non-IgE-mediated food allergy involving tumor necrosis factor-alpha (TNF-α). Many triggering foods exist but cow's milk, as in the case reported herein, is one of the most frequent. It can start early or be delayed and start around the average age of 5 months. Symptoms are nonspecific with diarrhea and vomiting, but in the presence of methemoglobinemia, the diagnosis must be seriously considered...
November 18, 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27816237/clinical-benefit-of-component-resolved-diagnosis-in-japanese-birch-allergic-patients-with-a-convincing-history-of-apple-or-peach-allergy
#3
Hideaki Shirasaki, Tetsuo Yamamoto, Shu Abe, Etsuko Kanaizumi, Megumi Kikuchi, Tetsuo Himi
OBJECTIVE: In northern Japan, birch pollen is the major allergen in pollinosis, while oral allergy syndrome (OAS) is caused primarily by apple and peach, and is almost exclusively related to birch pollinosis. To clarify the clinical benefit of allergen-based component-resolved diagnosis (CRD) in Japanese birch-allergic patients with OAS, we present an analysis of IgE profiles in response to crude extracts and recombinant component-resolved allergen to birch pollen and Rosaceae fruits allergens...
November 2, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/27738400/evaluation-of-the-patients-diagnosed-with-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-a-single-center-experience
#4
Şükrü Çekiç, Yakup Canıtez, Nihat Sapan
AIM: Stevens Johnson syndrome and toxic epidermal necrolysis are severe acute mucocutaneous diseases. In this study, we evaluated the clinical aspects of Steven Johnson syndrome, toxic epidermal necrolysis and Stevens-Johnson syndrome/toxic epidermal necrolysis overlap patients who admitted to our clinics in the last five years. MATERIAL AND METHODS: Eleven patients diagnosed as Stevens-Johnson syndrome, toxic epidermal necrolysis and Stevens-Johnson syndrome/toxic epidermal necrolysis overlap in Department of Pediatric Allergy in Uludağ University School of Medicine were included in this study...
September 2016: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/27687621/ofatumumab-in-two-pediatric-nephrotic-syndrome-patients-allergic-to-rituximab
#5
Marina Vivarelli, Manuela Colucci, Alice Bonanni, Martina Verzani, Jessica Serafinelli, Francesco Emma, Gianmarco Ghiggeri
BACKGROUND: Rituximab, a chimeric anti-CD20 monoclonal antibody, is an effective treatment in steroid-dependent nephrotic syndrome (SDNS). However, some patients develop adverse reactions. CASE-DIAGNOSIS/TREATMENT: Patient 1, a 14-year-old boy with SDNS since the age of 2, was treated with oral prednisone, cyclosporine A (CsA) and mycophenolate mofetil. A first infusion of rituximab at age 12 years was well tolerated, but this was followed by a prolonged relapse unresponsive to oral prednisone, mycophenolate mofetil and CsA...
September 29, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27663157/food-allergen-mediated-exacerbations-of-oral-lichen-planus
#6
H X Chen, W J Yount, D A Culton
Erosive oral lichen planus (OLP) is a chronic autoimmune condition of unknown aetiology, characterized by periods of exacerbation and quiescence. Many patients with OLP report triggers of flares that overlap with triggers of other oral diseases, including oral allergy syndrome (OAS), an IgE-mediated food allergy. We report a case that, to our knowledge, is the first reported case of concurrent OLP and OAS diagnoses, which provides insight into the triggers of OLP and the role of trigger avoidance. A woman in her 60s presented with erosive OLP refractory to prednisone and azathioprine...
October 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27593099/allergy-to-apple-cultivars-among-patients-with-birch-pollinosis-and-oral-allergy-syndrome
#7
Aneta Wagner, Angelika Szwed, Krzysztof Buczyłko, Waldemar Wagner
BACKGROUND: Oral allergy syndrome (OAS) is caused by cross-reacting allergens found in pollen, raw fruits, vegetables, and some tree nuts. The major apple allergen, Mal d 1, is a cause of food allergic reactions in birch pollen sensitized patients. OBJECTIVE: To explore the allergenicity of the most popular and commonly consumed apple cultivars in Poland in patients with birch pollen allergy with or without OAS. METHODS: Data were obtained from 46 adults with clinical symptoms of birch allergy and allergic rhinitis or rhinoconjunctivitis...
October 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27592278/food-allergy-in-catalonia-clinical-manifestations-and-its-association-with-airborne-allergens
#8
J Sánchez-López, V Gázquez, N Rubira, L Valdesoiro, M Guilarte, A Garcia-Moral, N Depreux, L Soto-Retes, M De Molina, O Luengo, R Lleonart, M Basagaña
BACKGROUND: Food allergy affects around 6% of the European population and its prevalence worldwide has been increasing in the last decades, but studies focused on investigating food allergy epidemiology in Europe are lacking. OBJECTIVE: The Cibus project was created to register the main culprit foods and their clinical manifestations in food allergic patients in Catalonia. METHODS: A specific online database was designed. Allergists from eight different Catalan hospitals registered the new diagnoses of food allergy...
August 31, 2016: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/27587983/unmet-diagnostic-needs-in-contact-oral-mucosal-allergies
#9
REVIEW
Paola Lucia Minciullo, Giovanni Paolino, Maddalena Vacca, Sebastiano Gangemi, Eustachio Nettis
The oral mucosa including the lips is constantly exposed to several noxious stimuli, irritants and allergens. However, oral contact pathologies are not frequently seen because of the relative resistance of the oral mucosa to irritant agents and allergens due to anatomical and physiological factors. The spectrum of signs and symptoms of oral contact allergies (OCA) is broad and a large number of condition can be the clinical expression of OCA such as allergic contact stomatitis, allergic contact cheilitis, geographic tongue, oral lichenoid reactions, burning mouth syndrome...
2016: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/27582401/clinical-significance-of-component-allergens-in-fagales-pollen-sensitized-peanut-allergy-in-korea
#10
Kyung Hee Park, Young Woong Son, Sang Chul Lee, Kyunguk Jeong, Da Woon Sim, Hye Jung Park, Sooyoung Lee, Jae Hyun Lee, Jung Won Park
PURPOSE: Clinical features of peanut allergy can range from localized to systemic reactions. Because peanut and birch pollen have cross-reactivity, peanut can lead to localized allergic reaction in Fagales pollen-sensitized oral allergy syndrome (OAS) patients without peanut sensitization per se. The purpose of this study was to discriminate true peanut food allergy from cross-reactive hypersensitivity in birch-sensitized peanut allergy. METHODS: Birch-sensitized (n=81) and peanut anaphylaxis patients (n=12) were enrolled...
November 2016: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/27580724/-mucosal-diseases-from-an-allergological-perspective
#11
I Schwarz, D Bokanovic, W Aberer
The oral allergy syndrome is one of the most common form of food allergy and manifests as contact urticaria of the oral mucosa after consumption of cross reacting foods. Whereas allergic contact stomatitis often occurs due to dental materials, allergic contact cheilitis is usually a reaction due to topical therapeutics like herpes ointments or lip care products. As late type reactions are more frequent than immediate type reactions in the anogenital mucosa, contact dermatitis in this area should be identified via epicutaneous testing...
October 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27567321/prevalence-of-oral-allergy-syndrome-in-children-with-allergic-diseases
#12
M Bedolla-Barajas, A Kestler-Gramajo, G Alcalá-Padilla, J Morales-Romero
INTRODUCTION: The oral allergy syndrome (OAS) is a particular type of food allergy rarely explored in the paediatric population that is already considered an adult problem. OBJECTIVE: Identify the prevalence of OAS, symptoms and pollen species associated with its presence in children affected by allergic diseases. METHODS: A cross-sectional study was conducted. Consecutive sampling included children from 6 to 14 years who needed allergy treatment for the first time...
August 24, 2016: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/27545065/humoral-and-cellular-responses-to-casein-in-patients-with-food-protein-induced-enterocolitis-to-cow-s-milk
#13
Jean Christoph Caubet, Ramon Bencharitiwong, Andrew Ross, Hugh A Sampson, M Cecilia Berin, Anna Nowak-Węgrzyn
BACKGROUND: Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy manifesting within 1 to 4 hours of food ingestion with repetitive emesis and lethargy. OBJECTIVE: We sought to characterize immune responses to casein in children with FPIES caused by cow's milk (CM). METHODS: Total IgE and IgM, CM-specific IgG, and casein-specific IgE, IgG, IgG4, and IgM levels, as well as immunoglobulin free light chains, were measured in both patients with active and those with resolved CM-FPIES...
July 15, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27498217/awareness-of-allergic-enterocolitis-among-primary-care-paediatricians-a-web-based-pilot-survey
#14
P Comberiati, M Landi, A Martelli, G L Piacentini, C Capristo, G Paiola, D G Peroni
BACKGROUND: Allergic enterocolitis, also known as food protein-induced enterocolitis syndrome (FPIES), is an increasingly reported and potentially severe non-IgE mediated food allergy of the first years of life, which is often misdiagnosed due to its non-specific presenting symptoms and lack of diagnostic guidelines. OBJECTIVE: We sought to determine the knowledge of clinical, diagnostic and therapeutic features of FPIES among Italian primary-care paediatricians...
September 2016: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/27470643/profiles-of-birch-sensitization-bet-v-1-bet-v-2-and-bet-v-4-and-oral-allergy-syndrome-across-italy
#15
G Ciprandi, P Comite, M Mussap, M De Amici, S Quaglini, F Barocci, G L Marseglia, E Scala
BACKGROUND: Birch allergy (BA) is a common pollinosis caused by the allergens Bet v 1, Bet v 2, and Bet v 4. Oral allergy syndrome (OAS) is frequently associated with BA. A gradient of sensitization to birch allergen across Europe has been reported. Therefore, this study aimed to investigate the birch sensitization profile, including OAS, across Italy. METHODS: We performed a retrospective study of 854 patients (391 males, mean age 35.9 years, range 18-93 years): 196 patients were recruited in Genoa, 188 in northern Italy, 359 in central Italy, and 111 in southern Italy...
2016: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/27388423/predominance-of-type-1-innate-lymphoid-cells-in-the-rectal-mucosa-of-patients-with-non-celiac-wheat-sensitivity-reversal-after-a-wheat-free-diet
#16
Diana Di Liberto, Pasquale Mansueto, Alberto D'Alcamo, Marianna Lo Pizzo, Elena Lo Presti, Girolamo Geraci, Francesca Fayer, Giuliana Guggino, Giuseppe Iacono, Francesco Dieli, Antonio Carroccio
OBJECTIVES: Non-celiac wheat sensitivity (NCWS) is defined as a reaction to ingested wheat after exclusion of celiac disease and wheat allergy. As its pathogenesis is incompletely understood, we evaluated the inflammatory response in the rectal mucosa of patients with well-defined NCWS. METHODS: The prospective study included 22 patients with irritable bowel syndrome (IBS)-like clinical presentation, diagnosed with NCWS by double-blind placebo-controlled challenge...
2016: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/27365254/profiles-of-birch-sensitization-bet-v-1-bet-v-2-bet-v-4-and-oral-allergy-syndrome-across-italy
#17
G Ciprandi, P Comite, M Mussap, M De Amici, S Quaglini, F Barocci, G Marseglia, E Scala
BACKGROUND: Birch allergy (BA) is a common pollinosis. Bet v 1, Bet v 2, and Bet v 4 are birch allergen molecules. Oral allergic syndrome (OAS) is frequently associated with BA. Previously, it has been reported that there is a gradient of birch allergen sensitization profile across Europe. Thus, this study aimed to investigate the birch sensitization profile, including OAS, across Italy. METHODS: This retrospective study considered a series of 854 patients (391 males, mean age 35...
April 11, 2016: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/27165578/nmr-resonance-assignments-of-the-major-apple-allergen-mal-d-1
#18
Linda Ahammer, Sarina Grutsch, Martin Tollinger
The major apple allergen Mal d 1 is the predominant cause of apple (Malus domestica) allergies in large parts of Europe and Northern America. Allergic reactions against this 17.5 kDa protein are the consequence of initial sensitization to the structurally homologous major allergen from birch pollen, Bet v 1. Consumption of apples can subsequently provoke immunologic cross-reactivity of Bet v 1-specific antibodies with Mal d 1 and trigger severe oral allergic syndroms, affecting more than 70 % of all individuals that are sensitized to birch pollen...
October 2016: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/27144039/a-case-of-sublingual-ranula-that-responded-successfully-to-localized-injection-treatment-with-ok-432-after-healing-from-drug-induced-hypersensitivity-syndrome
#19
Kunio Yoshizawa, Akinori Moroi, Shuichi Kawashiri, Koichiro Ueki
A ranula is a mucus retention cyst or pseudocyst caused by leakage of mucus from the sublingual gland and generally occurs in the oral floor. In addition, drug induced hypersensitivity syndrome (DIHS) is a rare but well-recognized serious adverse effect characterized by fever, skin rashes, generalized lymphadenopathy, hepatitis, and hepatosplenomegaly and oral stomatitis. This paper presents the first case of successfully treated sublingual ranula with localized injection of OK-432 after healing from drug induced hypersensitivity syndrome, which has previously been unreported in the literature...
2016: Case Reports in Dentistry
https://www.readbyqxmd.com/read/27075794/sensitization-profiles-to-peanut-allergens-in-belgium-cracking-the-code-in-infants-children-and-adults
#20
Margaretha A Faber, Inne Donné, Evelien Herrebosch, Vito Sabato, Margo M Hagendorens, Chris H Bridts, Luc S De Clerck, Didier G Ebo
OBJECTIVES: Peanut allergy shows distinct clinical patterns that can be predicted by component resolved diagnosis. However, data about peanut sensitization profiles in populations with a broad age stratification are scarce. METHODS: Sera of 89 peanut allergic patients (age 1-70 years), 21 infants (<1 year) with atopic dermatitis (AD) sensitized to peanut, 24 age matched peanut-tolerant individuals with positive specific IgE (sIgE) to peanut and 15 healthy individuals were tested for sIgE reactivity to rAra h 1, rAra h 2, rAra h 3, rAra h 8, rAra h 9 and rBet v 1 (FEIA ImmunoCAP, Thermo Fisher Scientific)...
February 2016: Acta Clinica Belgica
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