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Immunoglobulin e

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https://www.readbyqxmd.com/read/29907692/who-regulates-whom-znf341-is-an-additional-player-in-the-stat3-t-h-17-song
#1
REVIEW
Avery August
Deficiency of ZNF341, a transcription factor featuring 12 Cys2His2 zinc fingers that regulates the expression and autoinduction of STAT3 (signal transducer and activator of transcription 3), results in hyper-immunoglobulin E syndrome and defective T helper 17 cell differentiation in humans.
June 15, 2018: Science Immunology
https://www.readbyqxmd.com/read/29907691/a-recessive-form-of-hyper-ige-syndrome-by-disruption-of-znf341-dependent-stat3-transcription-and-activity
#2
Vivien Béziat, Juan Li, Jian-Xin Lin, Cindy S Ma, Peng Li, Aziz Bousfiha, Isabelle Pellier, Samaneh Zoghi, Safa Baris, Sevgi Keles, Paul Gray, Ning Du, Yi Wang, Yoann Zerbib, Romain Lévy, Thibaut Leclercq, Frédégonde About, Ai Ing Lim, Geetha Rao, Kathryn Payne, Simon J Pelham, Danielle T Avery, Elissa K Deenick, Bethany Pillay, Janet Chou, Romain Guery, Aziz Belkadi, Antoine Guérin, Mélanie Migaud, Vimel Rattina, Fatima Ailal, Ibtihal Benhsaien, Matthieu Bouaziz, Tanwir Habib, Damien Chaussabel, Nico Marr, Jamel El-Benna, Bodo Grimbacher, Orli Wargon, Jacinta Bustamante, Bertrand Boisson, Ingrid Müller-Fleckenstein, Bernhard Fleckenstein, Marie-Olivia Chandesris, Matthias Titeux, Sylvie Fraitag, Marie-Alexandra Alyanakian, Marianne Leruez-Ville, Capucine Picard, Isabelle Meyts, James P Di Santo, Alain Hovnanian, Ayper Somer, Ahmet Ozen, Nima Rezaei, Talal A Chatila, Laurent Abel, Warren J Leonard, Stuart G Tangye, Anne Puel, Jean-Laurent Casanova
Heterozygosity for human signal transducer and activator of transcription 3 ( STAT3 ) dominant-negative (DN) mutations underlies an autosomal dominant form of hyper-immunoglobulin E syndrome (HIES). We describe patients with an autosomal recessive form of HIES due to loss-of-function mutations of a previously uncharacterized gene, ZNF341 ZNF341 is a transcription factor that resides in the nucleus, where it binds a specific DNA motif present in various genes, including the STAT3 promoter. The patients' cells have low basal levels of STAT3 mRNA and protein...
June 15, 2018: Science Immunology
https://www.readbyqxmd.com/read/29907690/znf341-controls-stat3-expression-and-thereby-immunocompetence
#3
Stefanie Frey-Jakobs, Julia M Hartberger, Manfred Fliegauf, Claudia Bossen, Magdalena L Wehmeyer, Johanna C Neubauer, Alla Bulashevska, Michele Proietti, Philipp Fröbel, Christina Nöltner, Linlin Yang, Jessica Rojas-Restrepo, Niko Langer, Sandra Winzer, Karin R Engelhardt, Cristina Glocker, Dietmar Pfeifer, Adi Klein, Alejandro A Schäffer, Irina Lagovsky, Idit Lachover-Roth, Vivien Béziat, Anne Puel, Jean-Laurent Casanova, Bernhard Fleckenstein, Stephan Weidinger, Sara S Kilic, Ben-Zion Garty, Amos Etzioni, Bodo Grimbacher
Signal transducer and activator of transcription 3 (STAT3) is a central regulator of immune homeostasis. STAT3 levels are strictly controlled, and STAT3 impairment contributes to several diseases including the monogenic autosomal-dominant hyper-immunoglobulin E (IgE) syndrome (AD-HIES). We investigated patients of four consanguineous families with an autosomal-recessive disorder resembling the phenotype of AD-HIES, with symptoms of immunodeficiency, recurrent infections, skeletal abnormalities, and elevated IgE...
June 15, 2018: Science Immunology
https://www.readbyqxmd.com/read/29907668/longterm-outcomes-of-188-japanese-patients-with-eosinophilic-granulomatosis-with-polyangiitis
#4
Aiko Saku, Shunsuke Furuta, Masaki Hiraguri, Kei Ikeda, Yoshihisa Kobayashi, Shin-Ichiro Kagami, Kazuhiro Kurasawa, Ryutaro Matsumura, Daiki Nakagomi, Takao Sugiyama, Takeshi Umibe, Norihiko Watanabe, Hiroshi Nakajima
OBJECTIVE: Patients with eosinophilic granulomatosis with polyangiitis (EGPA) frequently experience relapses, which lead to cumulative organ damage. In this retrospective observational study, we aimed to reveal the risk factors for relapse in EGPA. METHODS: A total of 188 Japanese patients with EGPA diagnosed between 1996 and 2015 were identified from medical records in 10 hospitals. The diagnosis was based on the American College of Rheumatology 1990 criteria or Lanham's criteria...
June 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29906528/cd300c-co-stimulates-ige-mediated-basophils-activation-and-its-expression-is-increased-in-cow%C3%A2-s-milk-allergy
#5
Olatz Zenarruzabeitia, Joana Vitallé, Iñigo Terrén, Ane Orrantia, Itziar Astigarraga, Leire Dopazo, Carlos Gonzalez, Laura Santos-Díez, Carlos Tutau, Pedro M Gamboa, Agurtzane Bilbao, Francisco Borrego
BACKGROUND: Basophils express high-affinity IgE receptors (FcεRI), which play an essential role in allergic diseases. To design promising immunomodulatory therapies, it is important to characterize new cell surface receptors that modulate immunoglobulin (Ig)E-mediated basophil activation threshold. OBJECTIVES: To analyze the expression of CD300 receptors on human basophils and their implication in IgE-mediated basophil activation processes. METHODS: Blood samples from healthy and cow´s milk allergic patients were collected through the Basque Biobank under an institutional review board-approved protocol...
June 12, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29905497/synchronous-epstein-barr-virus-associated-skull-base-and-adrenal-smooth-muscle-tumors-in-an-8-year-old-girl-with-recent-epstein-barr-virus-infection
#6
Desmond A Brown, Nicholas L Deep, Colin L Driscoll, Michael J Link, Mark E Jentoft, David J Daniels
Epstein-Barr virus-associated smooth-muscle tumors are rare tumors seen in immunocompromised patients. Most cases occur in the context of AIDS and organ transplantation, and very rarely in the setting of congenital immunodeficiency, with only 5 case reports of the latter published so far in the literature. The authors report the case of a previously healthy 8-year-old girl with headaches and precocious puberty who was found to have a large skull base lesion. There was a synchronous left adrenal lesion. She underwent resection of the skull base lesion and a left adrenalectomy...
June 15, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29905462/the-human-biomolecular-corona-of-liposomal-doxorubicin-the-overlooked-factor-in-anticancer-drug-delivery
#7
Giulio Caracciolo, Sara Palchetti, Luca Digiacomo, Riccardo Zenezini Chiozzi, Anna Laura Capriotti, Heinz Amenitsch, Paolo Maria Tentori, Valentina Palmieri, Massimiliano Papi, Francesco Cardarelli, Daniela Pozzi, Aldo Laganà
More than twenty years after its approval by the Food and Drug Administration (FDA) liposomal doxorubicin (DOX) is still the drug of choice for the treatment of breast cancer and other conditions such as ovarian cancer and multiple myeloma. Yet, despite the efforts, liposomal DOX did not satisfy expectations at the clinical level. When liposomal drugs enter a physiological environment, their surface gets coated by a dynamic biomolecular corona (BC). The BC changes liposome's synthetic identity, providing it with a new one, referred to as 'biological identity' (size, aggregation state, and BC composition)...
June 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29903764/inferior-survival-in-high-grade-b-cell-lymphoma-with-myc-and-bcl2-and-or-bcl6-rearrangements-is-not-associated-with-myc-ig-gene-rearrangements
#8
Ellen D McPhail, Matthew J Maurer, William R Macon, Andrew L Feldman, Paul J Kurtin, Rhett P Ketterling, Rakhee Vaidya, James R Cerhan, Stephen M Ansell, Luis F Porrata, Grzegorz S Nowakowski, Thomas E Witzig, Thomas M Habermann
High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (double-/triple-hit lymphoma) has an aggressive clinical course. We investigated prognostic value of transformation from low-grade lymphoma, cytologic features (high grade versus large cell), MYC gene rearrangement partners (immunoglobulin versus nonimmunoglobulin gene), and treatment. We evaluated 100 adults with double-/triple-hit lymphoma, reviewing cytologic features; cell of origin; and rearrangements of MYC, BCL2, and BCL6 using MYC, BCL2, and BCL6 break-apart and IGH/MYC, IGL/MYC, IGK/MYC, and IGH/BCL2 dual-fusion interphase fluorescence in situ hybridization probes...
June 14, 2018: Haematologica
https://www.readbyqxmd.com/read/29902818/-substances-in-the-bovine-colostrum-a-survey
#9
Sebastian Ganz, Michael Bülte, Zdzislaw Gajewski, Axel Wehrend
The best studied substances in bovine colostrum are the immunoglobulins. They are absorbed in the small intestine of the neonate by pinocytosis. The Fc-receptor is not highly involved in this process in calves compared to other species. However, this receptor plays a crucial role in the transport of immunoglobulins from the circulation of the dam to the udder and, therefore, into the colostrum. During colostrogenesis, which starts up to 8 weeks prior to parturition, up to 500 g of immunoglobulins are transferred daily by this process...
June 2018: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/29902709/development-of-a-new-approach-of-immunotherapy-against-scorpion-envenoming-avian-igys-an-alternative-to-equine-iggs
#10
Amina Sifi, Sonia Adi-Bessalem, Fatima Laraba-Djebari
Antivenom treatment has been largely used against scorpion stings. Despite their efficacy, the use of mammalian antivenoms may cause adverse effects due to the immune system activation. IgYs from hyperimmunized laying hens against venoms could be a promising alternative to equine IgGs due to the various benefits that these antibodies can provide. Here we report the preparation of specific IgYs by immunizing laying hens with Aah (Androctonus australis hector) scorpion venom. IgYs were isolated from egg yolks by water dilution and salt precipitation methods; they were characterized by sodium dodecyl sulfate polyacrylamide gel electrophoresis, western blot and ELISA...
June 11, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29902645/serum-level-of-antibodies-against-hepatitis-b-core-protein-is-associated-with-clinical-relapse-after-discontinuation-of-nucleos-t-ide-analogue-therapy
#11
Heng Chi, Zhandong Li, Bettina E Hansen, Tao Yu, Xiaoyong Zhang, Jian Sun, Jinlin Hou, Harry L A Janssen, Jie Peng
BACKGROUND & AIMS: Levels of antibodies against the hepatitis B virus (HBV) core protein (anti-HBc) have been associated with response to nucleos(t)ide analogue and (peg)interferon therapy in patients with chronic HBV infection. We performed a prospective study to determine whether the total serum level of anti-HBc level (immunoglobulins M and G) is associated with clinical relapse after discontinuation of nucleos(t)ide analogue-based therapy. METHODS: We collected data from patients with chronic HBV infection who discontinued nucleos(t)ide analogue therapy according to pre-specified stopping criteria, recruited from November 2012 through July 2016 at an academic hospital in Guangzhou, China...
June 11, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29902633/proton-elisa-electrochemical-immunoassay-on-a-dual-gated-isfet-array
#12
Duane S Juang, Ching-Hui Lin, Yi-Ren Huo, Chia-Yu Tang, Chun-Ren Cheng, Hua-Shu Wu, Shih-Fen Huang, Alexander Kalnitsky, Chun-Cheng Lin
Here we report an electrochemical immunoassay platform called Proton-ELISA (H-ELISA) for the detection of bioanalytes. H-ELISA uniquely utilizes protons as an immunoassay detection medium, generated by the enzyme glucose oxidase (GOx) coupled with Fenton's reagent in a proton amplification reaction cascade that results in a highly amplified signal. A proton-sensitive dual-gated ion-sensitive field effect transistor (DG-ISFET) sensor was also developed for sensitive and accurate detection of the proton signal in H-ELISA...
June 7, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29902448/postponing-early-intrauterine-transfusion-with-intravenous-immunoglobulin-treatment-the-petit-study-on-severe-hemolytic-disease-of-the-fetus-and-newborn
#13
Carolien Zwiers, Johanna G van der Bom, Inge L van Kamp, Nan Van Geloven, Enrico Lopriore, John Smoleniec, Roland Devlieger, Pauline E Sim, Marie Anne Ledingham, Eleonor Tiblad, Kenneth J Moise, Karl-Philip Gloning, Mark D Kilby, Timothy G Overton, Ditte S Jørgensen, Katrine V Schou, Bettina Paek, Martin Walker, Emma Parry, Dick Oepkes, Masja de Haas
BACKGROUND: Intrauterine transfusion for severe alloimmunization in pregnancy performed before 20 weeks' gestation is associated with a higher fetal death rate. Intravenous immunoglobulins may prevent hemolysis and could therefore be a non-invasive alternative for early transfusions. OBJECTIVE(S): We evaluated whether maternal treatment with intravenous immunoglobulins defers the development of severe fetal anemia and its consequences in a retrospective cohort to which 12 fetal therapy centers contributed...
June 11, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29902238/laty136f-knock-in-mouse-model-for-human-igg4-related-disease
#14
Kazunori Yamada, Masahiko Zuka, Kiyoaki Ito, Keishi Mizuguchi, Yasushi Kakuchi, Tamehito Onoe, Yasunori Suzuki, Masakazu Yamagishi, Shozo Izui, Marie Malissen, Bernard Malissen, Mitsuhiro Kawano
BACKGROUND: The adaptor protein Linker for activation of T cell (LAT) is a key signaling hub used by the T cell antigen receptor. Mutant mice expressing loss-of-function mutations affecting LAT and including a mutation in which tyrosine 136 is replaced by a phenylalanine (LatY136F) develop lymphoproliferative disorder involving T helper type 2 effector cells capable of triggering a massive polyclonal B cell activation that leads to hypergammaglobulinemia G1 and E and to non-resolving inflammation and autoimmunity...
2018: PloS One
https://www.readbyqxmd.com/read/29901105/the-roles-of-the-tlr-nf%C3%A2-%C3%AE%C2%BAb-signaling-pathway-in-the-mutual-interactions-between-the-lung-and-the-large-intestine
#15
Wen Fu, Jing Zhao, Xinglong Liu, Yongxiang Gao, Chuan Zheng
The 'exterior-interior relationship between the lung and the large intestine' is a classical basic theory in Traditional Chinese Medicine. The present study aimed to investigate the roles of the toll like receptor/nuclear factor‑κB (TLR/NF‑κB) signaling pathway in the mutual interactions between the lung and the large intestine. A rat model of allergic asthma complicated with intestinal flora disorder was established by oral administration of Candida albicans and intraperitoneal injection with ovalbumin...
May 31, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29898247/batf-regulates-the-expression-of-nfil3-wnt10a-and-mir155hg-for-efficient-induction-of-antibody-class-switch-recombination-in-mice
#16
Rosemary E Morman, Patrick G Schweickert, Stephen F Konieczny, Elizabeth J Taparowsky
BATF functions in T cells and B cells to control the host response to antigen and promote the production of class switched immunoglobulins. In this study, we demonstrate that BATF expression increases rapidly, and transiently, following B cell stimulation and use an inducible murine model of BATF deletion to show that this induction is necessary, and sufficient, for immunoglobulin (Ig) class switch recombination (CSR). We examine two genes (Nfil3 and miR155gh) that are positively regulated, and one gene (Wnt10a) that is negatively regulated by BATF during CSR...
June 13, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29895783/immunological-comparison-of-native-and-recombinant-hen-s-egg-yolk-allergen-chicken-serum-albumin-gal-d-5-produced-in-kluveromyces-lactis
#17
Chamika De Silva, Pathum Dhanapala, Samuel King, Timothy Doran, Mimi Tang, Cenk Suphioglu
Chicken serum albumin (CSA) is a hen's egg yolk allergen causing IgE-mediated allergy. The objective of this study was to produce a recombinant version of CSA and compare its IgE reactivity to natural CSA (nCSA). CSA was cloned and expressed as a soluble fraction in the yeast Kluyveromyces lactis ( K. lactis ) protein expression system. The gene encoding CSA was amplified with a C -terminal hemagglutinin epitope tag by polymerase chain reaction (PCR) and cloned into the pKLAC2 expression vector prior to transforming into K...
June 12, 2018: Nutrients
https://www.readbyqxmd.com/read/29894999/grass-allergic-children-frequently-show-asymptomatic-low-level-ige-co-sensitization-and-cross-reactivity-to-wheat
#18
Nora Nilsson, Caroline Nilsson, Helena Ekoff, Sandra Wieser-Pahr, Magnus P Borres, Rudolf Valenta, Gunilla Hedlin, Sigrid Sjölander
BACKGROUND: Specific immunoglobulin E (IgE) sensitization to wheat is more common than a doctor's confirmed wheat allergy and is also frequently observed in grass pollen-allergic patients (pollinosis patients). Thus, the objective of this study was to investigate the level and feature of serological IgE cross-reactivity between grass pollen and wheat in a cohort of pollinosis subjects with no diagnosis of wheat allergy. METHODS: Seventy-two children, aged 5-17 years, with a doctor's diagnosis of pollinosis, IgE towards grass pollen, and currently eating wheat were recruited...
June 12, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29894863/against-nf-%C3%AE%C2%BAb-thymic-stromal-lymphopoietin-signaling-pathway-catechin-alleviates-the-inflammation-in-allergic-rhinitis
#19
Zengfeng Pan, Yuan Zhou, Xia Luo, Yan Ruan, Lian Zhou, Qing Wang, Ya Jie Yan, Qi Liu, Jinyan Chen
BACKGROUND: The prevalence of allergic rhinitis has risen sharply. Previous work has demonstrated the anti-inflammatory effect of catechin, including in models of allergic disease. However, the molecular mechanisms underlying this therapeutic effect remain unclear. Thymic stromal lymphopoietin(TSLP), as a molecule from epithelial cell, has been identified that plays a significant role in the development of allergic disease, and the production of TSLP is related to activation of the NF-κB signaling pathway...
June 8, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29893909/interleukin-6-and-tumor-growth-factor-%C3%AE-are-risk-factors-for-idiopathic-epistaxis
#20
Soheila Rahmanzadeh-Shahi, Ali Golshiri-Isfahani, Mahmood Sheikh Fathollahi, Mohammadtaghi Rezayati, Reza Bahramabadi, Mohammadreza Afrooz, Gholamreza Asadikaram, Derek Kennedy, Mohammad Kazemi Arababadi
Objective: To evaluate the serum levels of interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-α, tumor growth factor (TGF)-β, endothelin, and immunoglobulin (Ig)E in patients with idiopathic epistaxis, compared with healthy control individuals. Methods: Serum levels of IL-6, IL-8, TNF-α, TGF-β, endothelin, and IgE were evaluated in 110 patients with idiopathic epistaxis and 100 healthy controls using the enzyme-linked immunosorbent assay (ELISA) technique...
June 9, 2018: Laboratory Medicine
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