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https://www.readbyqxmd.com/read/28099303/quality-of-life-in-bilateral-vs-unilateral-end-stage-ankle-arthritis-and-outcomes-of-bilateral-vs-unilateral-total-ankle-replacement
#1
Sagar J Desai, Mark Glazebrook, Murray J Penner, Kevin J Wing, Alastair S E Younger, Ellie Pinsker, Timothy R Daniels
BACKGROUND: We performed a retrospective cohort study to compare preoperative health-related quality of life (HRQoL) between patients with bilateral and those with unilateral end-stage ankle arthritis. We also compared midterm outcomes in a subgroup of patients who had undergone staged bilateral total ankle replacement (TAR) with the outcomes in the group treated with unilateral TAR. METHODS: The HRQoL before surgical treatment was compared between 53 patients with bilateral end-stage ankle arthritis identified from the Canadian Orthopaedic Foot and Ankle Society Prospective Ankle Reconstruction Database and 106 patients with unilateral arthritis selected from the same database...
January 18, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28091705/bacteria-of-the-family-candidatus-midichloriaceae-in-sympatric-zones-of-ixodes-ticks-genetic-evidence-for-vertical-transmission
#2
Tatyana A Mukhacheva, Sergey Y Kovalev
Ixodes ticks transmit infectious agents and also harbor their own parasites and symbionts. The presumptive endosymbiont of Ixodes ricinus, 'Candidatus Midichloria mitochondrii', has a unique ability to invade mitochondria within tick ovarian cells and is transovarially transmitted with 100% efficiency. A closely related bacterium, provisionally named Montezuma (now 'Candidatus Lariskella arthropodarum'), was isolated from the Ixodes persulcatus ticks and human blood in 2004 as well as from Ixodes pavlovskyi in 2015...
January 14, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28079361/controllable-synthesis-of-smart-multifunctional-nanoscal-metal-organic-framework-for-magnetic-resonance-optical-imaging-and-targeted-drug-delivery
#3
Xuechuan Gao, Manjue Zhai, Weihua Guan, Jingjuan Liu, Zhiliang Liu, Alatangaole Damirin
As a result of their extraordinarily large surfaces and well-defined pores, the design of multifunctional metal-organic framework (MOF) is crucial for drug delivery while has been rarely reported. In this paper, a novel drug delivery system (DDS) based on nanoscale metal-organic framework (MOF) was developed for using in cancer diagnosis and therapy. This MOF based tumour targeting DDS was fabricated by a simple post-synthetic surface modification process. Firstly, magnetic mesoporous nanomaterial Fe-MIL-53-NH2 was devoted for encapsulating the drug and served as a magnetic resonance (MR) contrast agent...
January 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28062406/anatomically-preserved-strobili-and-leaves-from-the-permian-of-china-dorsalistachyaceae-fam-nov-broaden-knowledge-of-noeggerathiales-and-constrain-their-possible-taxonomic-affinities
#4
Shi-Jun Wang, Richard M Bateman, Alan R T Spencer, Jun Wang, Longyi Shao, Jason Hilton
PREMISE OF THE STUDY: Noeggerathiales are an extinct group of heterosporous shrubs and trees that were widespread and diverse during the Pennsylvanian-Permian Epochs (323-252 Ma) but are of controversial taxonomic affinity. Groups proposed as close relatives include leptosporangiate ferns, sphenopsids, progymnosperms, or the extant eusporangiate fern Tmesipteris. Previously identified noeggerathialeans lacked anatomical preservation, limiting taxonomic comparisons to their external morphology and spore structure...
January 6, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/28056380/shedding-light-on-the-polyphyletic-thecate-amoeba-genus-plagiophrys-transition-of-some-of-its-species-to-rhizaspis-tectofilosida-thecofilosea-cercozoa-and-the-establishment-of-sacciforma-gen-nov-and-rhogostomidae-fam-nov-cryomonadida-thecofilosea-cercozoa
#5
Kenneth Dumack, Hüsna Öztoprak, Lioba Rüger, Michael Bonkowski
For over a century testate amoebae have been a favoured group of interest for protistologists, however there is still an endless amount of unanswered questions. The genus Plagiophrys, Claparède and Lachmann 1859, is still one of the unresolved mysteries as it comprises species with high morphological diversity of which no molecular data are available. To shed light on the phylogeny and taxonomy of Plagiophrys we (a) cultured four isolates of three Plagiophrys morphospecies and provided morphological observations (b) obtained three new SSU RNA gene sequences and conducted phylogenetic analyses of the Thecofilosea and (c) did intensive literature research, showing that Plagiophrys is polyphyletic...
December 7, 2016: Protist
https://www.readbyqxmd.com/read/28055181/fluorescent-branched-rnas-for-high-throughput-analysis-of-dbr1-enzyme-kinetics-and-inhibition
#6
Adam Katolik, Nathaniel E Clark, Nobuhiro Tago, Eric J Montemayor, P John Hart, Masad J Damha
We have developed fluorescent 2',5' branched RNAs (bRNA) that permit real time monitoring of RNA lariat (intron) debranching enzyme (Dbr1) kinetics. These compounds contain fluorescein (FAM) on the 5' arm of the bRNA that is quenched by a dabcyl moiety on the 2' arm. Dbr1-mediated hydrolysis of the 2',5' linkage induces a large increase in fluorescence, providing a convenient assay for Dbr1 hydrolysis. We show that unlabeled bRNAs with non-native 2',5'-phosphodiester linkages, such as phosphoramidate or phosphorothioate, can inhibit Dbr1-mediated debranching with IC50 values in the low nanomolar range...
January 18, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28054727/direct-comparison-of-point-by-point-and-rapid-ultra-high-resolution-electroanatomical-mapping-in-patients-scheduled-for-ablation-of-atrial-fibrillation
#7
Laura Rottner, Andreas Metzner, Feifan Ouyang, Christian Heeger, Kentaro Hayashi, Thomas Fink, Christine Lemes, Shibu Mathew, Tilman Maurer, Bruno REIßMANN, Enida Rexha, Johannes Riedl, Ardan M Saguner, Francesco Santoro, Karl-Heinz Kuck, Christian Sohns
INTRODUCTION: 3D electroanatomical mapping (EAM) is an established tool facilitating catheter ablation. In this context the novel Rhythmia system sets a new bar in fast high-resolution mapping. The aim of this study was to directly compare point-by-point versus rapid ultra high-resolution EAM in patients scheduled for ablation of atrial fibrillation (AF) with focus on procedural data, acute success and mid-term clinical outcome. METHODS AND RESULTS: A total number of 74 consecutive patients (48/74 male) with symptomatic AF were scheduled to undergo pulmonary vein isolation (PVI) using either Carto or Rhythmia...
January 5, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28047206/tu-h-campus-tep2-04-measurement-of-stereotactic-output-factors-with-dna-double-strand-breaks
#8
K Cline, M Obeidat, S Stathakis, C Kabat, M Markovic, N Papanikolaou, K Rasmussen, A Gutierrez, C Ha, S Lee, E Shim, N Kirby
PURPOSE: Radiotherapy treatment is specified by radiation dose prescriptions, but biological DNA damage actually controls treatment effectiveness. It is impractical to directly measure dose in the clinic, so we measure quantities, such as collected charge, and calculate the relationship to dose. At small fields, such as those in stereotactic radiosurgery (SRS), charged-particle equilibrium (CPE) breaks down and the accuracy of the measurement for delivered dose decreases. By measuring DNA double-strand breaks (DSB) directly, we believe treatment accuracy could improve by providing a more meaningful measurement...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045167/cdc20sirna-and-paclitaxel-co-loaded-nanometric-liposomes-of-a-nipecotic-acid-derived-cationic-amphiphile-inhibit-xenografted-neuroblastoma
#9
Sukanya Bhunia, Vegesna Radha, Arabinda Chaudhuri
Despite significant recent progress in the area of translational genomics of neuroblastoma, the overall survival rates for children with high-risk NB continue to be not more than 5 years due to tumor relapse and/or drug-resistant tumors. Herein we report on the development of a neuroblastoma targeting nanometric (130-150 nm) circulation stable liposomal system prepared from a novel nipecotic acid-derived cationic amphiphile (NACA). The size ranges of liposomes (130-150 nm) were confirmed by both dynamic light scattering and transmission electron microscopy...
January 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28033645/the-facial-adipose-tissue-a-revision
#10
Ilja Kruglikov, Oscar Trujillo, Quick Kristen, Kerelos Isac, Julia Zorko, Maria Fam, Kasie Okonkwo, Asima Mian, Hyunh Thanh, Konstantin Koban, Anthony P Sclafani, Hanno Steinke, Sebastian Cotofana
Recent advantages in the anatomical understanding of the face have turned the focus toward the subcutaneous and deep facial fat compartments. During facial aging, these fat-filled compartments undergo substantial changes along with other structures in the face. Soft tissue filler and fat grafting are valid methods to fight the signs of facial aging, but little is known about their precise effect on the facial fat. This narrative review summarizes the current knowledge about the facial fat compartments in terms of anatomical location, histologic appearance, immune-histochemical characteristics, cellular interactions, and therapeutic options...
December 2016: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28030580/historic-late-blight-outbreaks-caused-by-a-widespread-dominant-lineage-of-phytophthora-infestans-mont-de-bary
#11
Amanda C Saville, Michael D Martin, Jean B Ristaino
Phytophthora infestans (Mont.) de Bary, the causal agent of potato late blight, was responsible for the Irish potato famine of the 1840s. Initial disease outbreaks occurred in the US in 1843, two years prior to European outbreaks. We examined the evolutionary relationships and source of the 19th-century outbreaks using herbarium specimens of P. infestans from historic (1846-1970) and more recent isolates (1992-2014) of the pathogen. The same unique SSR multilocus genotype, named here as FAM-1, caused widespread outbreaks in both US and Europe...
2016: PloS One
https://www.readbyqxmd.com/read/28030492/stapled-versus-handsewn-a-prospective-emergency-surgery-study-shapes-an-american-association-for-the-surgery-of-trauma-multi-institutional-study
#12
Brandon R Bruns, David S Morris, Martin Zielinski, Nathan T Mowery, Preston R Miller, Kristen Arnold, Herb A Phelan, Jason Murry, David Turay, John Fam, John S Oh, Oliver L Gunter, Toby Enniss, Joseph D Love, David Skarupa, Matthew Benns, Alisan Fathalizadeh, Pak Shan Leung, Matthew M Carrick, Brent Jewett, Joseph Sakran, Lindsay O'Meara, Anthony V Herrera, Hegang Chen, Thomas M Scalea, Jose J Diaz
BACKGROUND: Data from the trauma patient population suggests handsewn anastomoses (HS) are superior to stapled (ST). A recent retrospective study in emergency general surgery (EGS) patients had similar findings. The aim of the current study is to evaluate HS and ST anastomoses in EGS patients undergoing urgent/emergent operations. METHODS: The study was sponsored by the AAST Multi-Institutional Studies Committee. Patients undergoing urgent/emergent bowel resection for EGS pathology were prospectively enrolled from 7/22/2013-12/31/2015...
December 23, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28029758/adoption-and-foster-care-analysis-and-reporting-system-final-rule
#13
(no author information available yet)
The Social Security Act (the Act) requires that ACF regulate a national data collection system that provides comprehensive demographic and case-specific information on children who are in foster care and adopted. This final rule replaces existing Adoption and Foster Care Analysis and Reporting System (AFCARS) regulations and the appendices to require title IV-E agencies to collect and report data to ACF on children in out-of-home care, and who exit out-of-home care to adoption or legal guardianship, children in out-of-home care who are covered by the Indian Child Welfare Act, and children who are covered by a title IV-E adoption or guardianship assistance agreement...
14, 2016: Federal Register
https://www.readbyqxmd.com/read/28027824/protective-effect-of-chamomile-matricaria-recutita-l-decoction-extract-against-alcohol-induced-injury-in-rat-gastric-mucosa
#14
Mohamed-Amine Jabri, Nadhem Aissani, Haifa Tounsi, Mohsen Sakly, Lamjed Marzouki, Hichem Sebai
BACKGROUND: Matricaria recutita L. (Asteraceae), German chamomile, has been widely used in the traditional Tunisian medicine because of having the powerful health benefits. the current study was conducted to determine the protective effect of chamomile (Matricaria recutita L.) decoction extract (CDE) in ethanol-induced ulcer and oxidative stress on gastric mucosa in rat. METHODS: Adult male wistar rats were used and divided into seven groups: Control, EtOH, EtOH+various doses of CDE (25, 50 and 100mg/kg, b...
December 21, 2016: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28017371/mixed-model-association-with-family-biased-case-control-ascertainment
#15
Tristan J Hayeck, Po-Ru Loh, Samuela Pollack, Alexander Gusev, Nick Patterson, Noah A Zaitlen, Alkes L Price
Mixed models have become the tool of choice for genetic association studies; however, standard mixed model methods may be poorly calibrated or underpowered under family sampling bias and/or case-control ascertainment. Previously, we introduced a liability threshold-based mixed model association statistic (LTMLM) to address case-control ascertainment in unrelated samples. Here, we consider family-biased case-control ascertainment, where case and control subjects are ascertained non-randomly with respect to family relatedness...
January 5, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28006714/-skinny-is-prettier-and-normal-i-want-to-be-normal-perceived-body-image-of-non-western-ethnic-minority-children-in-the-netherlands
#16
Jolanda Veldhuis, Fam Te Poel, Rian Pepping, Elly A Konijn, Marloes L C Spekman
While the prevalence of overweight and obesity is higher among children of some non-Western ethnic minorities than among their Caucasian counterparts, their body image is understudied. The current study examined the body image of Dutch children of non-Western ethnic minorities (i.e., Surinamese, Antillean, Moroccan, and Turkish). Sociocultural influences from school, media and home environments and their perceptions of overweight prevention programs were taken into account. Fifty-two non-Western ethnic minority children (aged 8-12 years) participated in semi-structured interviews and focus groups...
December 19, 2016: Body Image
https://www.readbyqxmd.com/read/27997060/comparison-of-left-atrial-bipolar-voltage-and-scar-using-multielectrode-fast-automated-mapping-versus-point-by-point-contact-electroanatomic-mapping-in-patients-with-atrial-fibrillation-undergoing-repeat-ablation
#17
Jackson J Liang, Melissa A Elafros, Daniele Muser, Rajeev K Pathak, Pasquale Santangeli, Gregory E Supple, Robert D Schaller, David S Frankel, Sanjay Dixit
INTRODUCTION: Bipolar voltage criteria to delineate left atrial (LA) scar have been derived using point-by-point (PBP) contact electroanatomical mapping. It remains unclear how PBP-derived LA scar correlates with multielectrode fast automated mapping (ME-FAM) derived scar. We aimed to correlate scar and bipolar voltages from LA maps created using PBP versus ME-FAM. METHODS AND RESULTS: In consecutive patients undergoing repeat AF ablation, 2 separate LA maps were created using PBP and ME-FAM during sinus rhythm before ablation...
December 20, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27989796/altered-sox9-genital-tubercle-enhancer-region-in-hypospadias
#18
REVIEW
Rajini Sreenivasan, Christopher T Gordon, Sabina Benko, Robb de Iongh, Stefan Bagheri-Fam, Stanislas Lyonnet, Vincent Harley
Human mutations in the SOX9 gene or its regulatory region can disrupt testicular development, leading to disorders of sex development (DSDs). Our previous work involving the genomic analysis of isolated DSD patients revealed a 78kb minimal sex determining region (RevSex) far upstream of SOX9 that was duplicated in 46,XX and deleted in 46,XY DSDs. It was postulated that RevSex contains a gonadal enhancer. However, the most highly conserved sub-region within RevSex, called SR4, was neither responsive to sex determining factors in vitro nor active in the gonads of transgenic mice, suggesting that SR4 may not be functioning as a testicular enhancer...
October 28, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27988727/a-review-of-the-families-and-genera-of-the-superfamily-platysceloidea-bowman-amp-gruner-1973-crustacea-amphipoda-hyperiidea-together-with-keys-to-the-families-genera-and-species
#19
Wolfgang Zeidler
The systematics and phylogenetic relationships of the families and genera of the superfamily Platysceloidea are examined, following a thorough examination of the morphology of an example of the type species of each genus, or a substitute species if the true identity of the type species is in doubt. The mouthparts are described for each type species, often for the first time, providing additional characters for phylogenetic analysis. Genera are diagnosed using the taxonomic database program DELTA (Dalwitz et al...
November 13, 2016: Zootaxa
https://www.readbyqxmd.com/read/27969793/tct-440-impact-of-optimal-implantation-technique-on-bioresorbable-scaffold-expansion-and-one-year-clinical-outcomes-in-patients-presenting-with-acute-coronary-syndromes-and-calcified-lesions-a-pooled-analysis-of-bvs-stemi-first-and-bvs-expand-studies
#20
Mariusz Tomaniak, Cordula Felix, Jiang Ming Fam, Robert-Jan van Geuns, Nicolas Van Mieghem, Evelyn Regar, Joost Daemen, Felix Zijlstra, Roberto Diletti
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
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