keyword
https://read.qxmd.com/read/36967414/insulin-signaling-in-skeletal-muscle-during-inflammation-and-or-immobilisation
#21
JOURNAL ARTICLE
Julius J Grunow, Thomas Gan, Heidrun Lewald, J A Jeevendra Martyn, Manfred Blobner, Stefan J Schaller
BACKGROUND: The decline in the downstream signal transduction pathway of anabolic hormone, insulin, could play a key role in the muscle atrophy and insulin resistance observed in patients with intensive care unit acquired weakness (ICUAW). This study investigated the impact of immobilisation via surgical knee and ankle fixation and inflammation via Corynebacterium parvum injection, alone and in combination, as risk factors for altering insulin transduction and, therefore, their role in ICUAW...
March 27, 2023: Intensive Care Medicine Experimental
https://read.qxmd.com/read/36934222/quantitative-muscle-mri-displays-clinically-relevant-myostructural-abnormalities-in-long-term-icu-survivors-a-case-control-study
#22
JOURNAL ARTICLE
R Rehmann, E Enax-Krumova, C H Meyer-Frießem, L Schlaffke
BACKGROUND: Long-term data on ICU-survivors reveal persisting sequalae and a reduced quality-of-life even after years. Major complaints are neuromuscular dysfunction due to Intensive care unit acquired weakness (ICUAW). Quantitative MRI (qMRI) protocols can quantify muscle alterations in contrast to standard qualitative MRI-protocols. METHODS: Using qMRI, the aim of this study was to analyse persisting myostructural abnormalities in former ICU patients compared to controls and relate them to clinical assessments...
March 18, 2023: BMC Medical Imaging
https://read.qxmd.com/read/36910489/development-and-validation-of-an-intensive-care-unit-acquired-weakness-prediction-model-a-cohort-study
#23
JOURNAL ARTICLE
Zi Yang, Xiaohui Wang, Guangming Chang, Qiuli Cao, Faying Wang, Zeyu Peng, Yuying Fan
BACKGROUND: At present, intensive care unit acquired weakness (ICU-AW) has become an important health care issue. The aim of this study was to develop and validate an ICU-AW prediction model for adult patients in intensive care unit (ICU) to provide a practical tool for early clinical diagnosis. METHODS: An observational cohort study was conducted including 400 adult patients admitted from September 2021 to June 2022 at an ICU with four ward at a medical university affiliated hospital in China...
2023: Frontiers in Medicine
https://read.qxmd.com/read/36874293/perceived-barriers-to-mobility-in-the-intensive-care-units-of-singapore-the-patient-mobilisation-attitudes-and-beliefs-survey-for-the-intensive-care-units
#24
JOURNAL ARTICLE
Meredith T Yeung, Nicholas K Tan, Gideon Z Lee, Yuemian Gao, Chun Ju Tan, Clement C Yan
PURPOSE: Prolonged bed rest and immobility in the intensive care units (ICU) increase the risk of ICU-acquired weakness (ICUAW) and other complications. Mobilisation has been shown to improve patient outcomes but may be limited by the perceived barriers of healthcare professionals to mobilisation. The Patient Mobilisation Attitudes and Beliefs Survey for the ICU (PMABS-ICU) was adapted to assess perceived barriers to mobility in the Singapore context (PMABS-ICU-SG). METHODS: The 26-item PMABS-ICU-SG was disseminated to doctors, nurses, physiotherapists, and respiratory therapists working in ICU of various hospitals across Singapore...
February 2023: Journal of the Intensive Care Society
https://read.qxmd.com/read/36846543/-robotic-assisted-mobilization-for-an-effective-mobilization-in-a-covid-19-patient-with-ecmo-treatment
#25
JOURNAL ARTICLE
Frank Dieterich, Jan Perras, Wolfram Popp, Marlena Ahrens, Steffen Wirth
An effective (early) mobilization in COVID-19 intensive care patients with ECMO treatment is very important. Sedation, extracorporeal procedures with the danger of circuit malfunction, large lumen ECMO cannulas with a risk of dislocation and a very severe neuromuscular weakness are factors that could deem mobilization beyond stage 1 of the ICU mobility score (IMS) in some cases difficult or impossible; however, early mobilization is a key point of the ABCDEF bundle to counteract pulmonary complications, neuromuscular dysfunction and enable recovery...
2023: Procare: Das Forbildungsmagazin Fur Pflegeberufe
https://read.qxmd.com/read/36794932/neurological-complications-of-sepsis
#26
REVIEW
Simone Piva, Michele Bertoni, Nicola Gitti, Francesco A Rasulo, Nicola Latronico
PURPOSE OF REVIEW: Sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, is a leading cause of hospital and ICU admission. The central and peripheral nervous system may be the first organ system to show signs of dysfunction, leading to clinical manifestations such as sepsis-associated encephalopathy (SAE) with delirium or coma and ICU-acquired weakness (ICUAW). In the current review, we want to highlight developing insights into the epidemiology, diagnosis, prognosis, and treatment of patients with SAE and ICUAW...
April 1, 2023: Current Opinion in Critical Care
https://read.qxmd.com/read/36611513/feasibility-of-muscle-endurance-testing-in-critically-ill-trauma-patients-a-pilot-study
#27
JOURNAL ARTICLE
Sun Hyun Kim, Ho Jeong Shin, Myung-Jun Shin, Myung Hun Jang
Intensive care unit-acquired weakness (ICUAW) occurs secondary to patients treated for life-threatening conditions in the ICU being diagnosed based on the Medical Research Council sum score (MRC-SS). However, patients often complain of fatigability and poor endurance, which are not evaluated by muscle strength. In this study, we explored the feasibility of assessing muscle quality and endurance in trauma ICU patients. The modified Functional Index-2 (FI2) testing was applied to evaluate muscle endurance. The maximal voluntary contraction (MVC) was measured when evaluating the MRC-SS using surface electromyography (sEMG), and the fatigue index (FI) was also recorded at the time of endurance testing...
December 24, 2022: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/36567787/bioenergetic-crisis-in-icu-acquired-weakness-gene-signatures-was-associated-with-sepsis-related-mortality-a-brief-report
#28
JOURNAL ARTICLE
Seibi Kobara, Milad G Rad, Jocelyn R Grunwell, Craig M Coopersmith, Rishikesan Kamaleswaran
UNLABELLED: To investigate the relationship between ICU-acquired weakness (ICUAW) signatures and sepsis-related mortality using gene expression from the blood within 24 hours of sepsis onset. DESIGN: Observational study using differential gene expression analysis. SETTING: Publicly available gene expression profile GSE54514, single-center medical and surgical ICU. PATIENTS: Patients with primary bacteremia- and respiratory-triggered sepsis including 8 nonsurvivors and 13 survivors who were 18 years old and older and admitted to ICU...
December 2022: Critical care explorations
https://read.qxmd.com/read/36520214/-neurointensive-care-medicine-and-covid-19
#29
REVIEW
Konstantinos Dimitriadis, Moritz Schmidbauer, Julian Bösel
This review article summarizes important findings on the interfaces between the coronavirus disease 2019 (COVID-19) pandemic and neurology with an emphasis of the implications for neurointensive care medicine. More specifically, the prevalence, pathomechanisms and impact of neurological manifestations are reported. The most common neurological manifestations of critically ill COVID-19 patients are cerebrovascular complications, encephalopathies and intensive care unit-acquired weakness (ICUAW). A relevant direct pathophysiological effect by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) itself has not yet been established with certainty...
December 15, 2022: Der Nervenarzt
https://read.qxmd.com/read/36405697/the-role-of-nlrp3-inflammasome-in-inflammation-related-skeletal-muscle-atrophy
#30
REVIEW
Yukun Liu, Dongfang Wang, Tianyu Li, Fan Yang, Zhanfei Li, Xiangjun Bai, Yuchang Wang
Skeletal muscle atrophy is a common complication in survivors of sepsis, which affects the respiratory and motor functions of patients, thus severely impacting their quality of life and long-term survival. Although several advances have been made in investigations on the pathogenetic mechanism of sepsis-induced skeletal muscle atrophy, the underlying mechanisms remain unclear. Findings from recent studies suggest that the nucleotide-binding and oligomerisation domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, a regulator of inflammation, may be crucial in the development of skeletal muscle atrophy...
2022: Frontiers in Immunology
https://read.qxmd.com/read/36400166/muscle-weakness-in-critically-ill-patients-effects-of-a-systematized-rehabilitation-nursing-program
#31
JOURNAL ARTICLE
Paulo Azevedo, Bárbara Gomes, José Macedo, Soraia Ferreira, José Pereira, Ana Pires
OBJECTIVE: Intensive care unit-acquired muscle weakness (ICUAW) in critically ill patients is frequent and associated with negative outcomes. Early rehabilitation is a strategy to improve outcomes. The aim was to assess the effects of a rehabilitation nursing programme at discharge from intensive care unit. METHODS: Quasi-experimental study with the comparison between two groups: one enrolled in a systematized nursing rehabilitation program and the other with usual nursing rehabilitation care...
November 15, 2022: Enfermería clínica (English Edition)
https://read.qxmd.com/read/36278257/association-between-daily-average-of-mobility-achieved-during-physical-therapy-sessions-and-hospital-acquired-or-ventilator-associated-pneumonia-among-critically-ill-patients
#32
JOURNAL ARTICLE
Wei Qi, Terrence E Murphy, Margaret M Doyle, Lauren E Ferrante
PURPOSE: Hospital-acquired and ventilator-associated pneumonias (HAP and VAP) are associated with increased morbidity and mortality. Immobility is a risk factor for developing ICU-acquired weakness (ICUAW). Early mobilization is associated with improved physical function, but its association with hospital-acquired (HAP) and ventilator-associated pneumonias (VAP) is unknown. The purpose of this study is to evaluate the association between daily average of highest level of mobility achieved during physical therapy (PT) and incidence of HAP or VAP among critically ill patients...
May 2023: Journal of Intensive Care Medicine
https://read.qxmd.com/read/36227022/comparison-of-different-ultrasound-methods-to-assess-changes-in-muscle-mass-in-critically-ill-patients
#33
JOURNAL ARTICLE
Kristina E Fuest, Hugo Lanz, Jana Schulz, Bernhard Ulm, Victoria A Bennett, Julius J Grunow, Björn Weiss, Manfred Blobner, Stefan J Schaller
BACKGROUND: Muscle ultrasound represents a promising approach to aid diagnoses of neuromuscular diseases in critically ill patients. Unfortunately, standardization of ultrasound measurements in clinical research is lacking, making direct comparisons between studies difficult. Protocols are required to assess qualitative muscle changes during an ICU stay in patients at high risk for the development of neuromuscular acquired weakness (ICUAW). METHODS: We conducted a retrospective, observational analysis comprised of three prospective observational studies with the aim of diagnosing muscle changes by ultrasound measurement of the quadriceps muscle...
May 2023: Journal of Intensive Care Medicine
https://read.qxmd.com/read/36149467/-robotic-assisted-mobilization-for-an-effective-mobilization-in-a-covid-19-patient-with-ecmo-treatment
#34
REVIEW
F Dieterich, J Perras, W Popp, M Ahrens, S Wirth
An effective (early) mobilization in COVID-19 intensive care patients with ECMO treatment is very important. Sedation, extracorporeal procedures with the danger of circuit malfunction, large lumen ECMO cannulas with a risk of dislocation and a very severe neuromuscular weakness are factors that could deem mobilization beyond stage 1 of the ICU mobility score (IMS) in some cases difficult or impossible; however, early mobilization is a key point of the ABCDEF bundle to counteract pulmonary complications, neuromuscular dysfunction and enable recovery...
September 23, 2022: Anaesthesiologie
https://read.qxmd.com/read/35946079/recovery-of-skeletal-muscle-strength-and-physical-function-in-a-patient-with-post-covid-19-requiring-extra-corporeal-membrane-oxygenation
#35
JOURNAL ARTICLE
Annefleur Lugthart, Stefan Sandker, Jacinta Maas, Jorge López Matta, Marlies Henneman, Carlos Elzo Kraemer, Maarten Werkman
BACKGROUND: The ongoing coronavirus-19 disease (COVID-19) has taught us that early mobilization is essential for functional recovery during and after prolonged intensive care unit (ICU) stay. This especially applies for patients receiving a challenging combination of prolonged invasive treatments such as mechanical ventilation (MV) and extra-corporeal membrane oxygenation (ECMO). This case report describes the recovery of skeletal muscle strength and physical function in a patient (post) COVID-19 during ICU stay...
August 9, 2022: Physiotherapy Theory and Practice
https://read.qxmd.com/read/35935791/occurrence-and-effects-on-weaning-from-mechanical-ventilation-of-intensive-care-unit-acquired-and-diaphragm-weakness-a-pilot-study
#36
JOURNAL ARTICLE
Michele Bertoni, Simone Piva, Alessandra Beretta, Federica Bongiovanni, Riccardo Contarino, Ricard Mellado Artigas, Lucia Ceresoli, Mattia Marchesi, Michele Falappi, Marta Belleri, Alberto Goffi, Matteo Pozzi, Frank Antonio Rasulo, Nicola Latronico
PURPOSE: Limb intensive care unit (ICU)-acquired weakness (ICUAW) and ICU acquired diaphragm weakness (DW) occur frequently in mechanically ventilated (MV) patients; their coexistence in cooperative and uncooperative patients is unknown. This study was designed to (1) describe the co-occurrence of the two conditions (2) evaluate the impact of ICUAW and DW on the ventilator-free days (VFDs) at 28 days and weaning success, and (3) assess the correlation between maximal inspiratory pressure (MIP) and thickening fraction (TFdi) in patients with DW...
2022: Frontiers in Medicine
https://read.qxmd.com/read/35922829/muscular-myostatin-gene-expression-and-plasma-concentrations-are-decreased-in-critically-ill-patients
#37
JOURNAL ARTICLE
Julius J Grunow, Katja Reiher, Niklas M Carbon, Lilian Jo Engelhardt, Knut Mai, Susanne Koch, Joerg C Schefold, Werner Z'Graggen, Stefan J Schaller, Jens Fielitz, Joachim Spranger, Steffen Weber-Carstens, Tobias Wollersheim
BACKGROUND: The objective was to investigate the role of gene expression and plasma levels of the muscular protein myostatin in intensive care unit-acquired weakness (ICUAW). This was performed to evaluate a potential clinical and/or pathophysiological rationale of therapeutic myostatin inhibition. METHODS: A retrospective analysis from pooled data of two prospective studies to assess the dynamics of myostatin plasma concentrations (day 4, 8 and 14) and myostatin gene (MSTN) expression levels in skeletal muscle (day 15) was performed...
August 3, 2022: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/35800084/case-report-functional-outcome-of-covid-19-subjects-with-myasthenia-gravis-and-critical-illness-polyneuropathy
#38
Domenico Intiso, Antonello Marco Centra, Luigi Amoruso, Michele Gravina, Filomena Di Rienzo
Background: The COVID-19 disease can affect subjects suffering from myasthenia gravis (MG) and worsen its clinical course, leading to intensive care unit (ICU) admission. Critically ill subjects can develop a neuromuscular complication called ICU-acquired weakness (ICUAW). This disorder has also been detected in ICU subjects with COVID-19, but the association between MG and ICUAW has never been described in critically ill patients. We describe the case and functional outcome of a COVID-19 patient suffering from MG who developed critical illness polyneuropathy (CIP)...
2022: Frontiers in Neurology
https://read.qxmd.com/read/35797827/the-possible-predictive-value-of-muscle-ultrasound-in-the-diagnosis-of-icuaw-in-long-term-critically-ill-patients
#39
JOURNAL ARTICLE
Formenti Paolo, De Giorgis Valentina, Coppola Silvia, Pozzi Tommaso, Chiodaroli Elena, Dres Martin, J Marini John, Chiumello Davide
PURPOSE: Intensive Care Unit acquired weakness (ICUAW) occurs commonly. Muscular ultrasonography allows visualization and classification of muscle characteristics. The aims of this study were to evaluate peripheral and respiratory muscles, their changes during long-term ICU stays, and the possible diagnostic predictive value of ICUAW as compared to the Medical Research Council strength score (MRC-SS). MATERIALS: 50 mechanically ventilated patients were enrolled...
October 2022: Journal of Critical Care
https://read.qxmd.com/read/35790678/multimodal-assessment-of-intensive-care-unit-acquired-weakness-in-severe-stroke-patients
#40
JOURNAL ARTICLE
Berin Inan, Can Ebru Bekircan-Kurt, Zeynep Ergul-Ulger, Merve Yilmaz, Zeliha Gunnur Dikmen, Ethem Murat Arsava, Mehmet Akif Topcuoglu, Omur Caglar, Merve Basol, Ergun Karaagaoglu, Sevim Erdem-Ozdamar, Ersin Tan, Cagri Mesut Temucin
BACKGROUND: Intensive care unit-acquired weakness (ICUAW) defines generalized muscle weakness seen in critically ill patients in the absence of other causative factors. Herein, we aimed to evaluate ICUAW in stroke patients by electrodiagnostic testing, histopathology, and assessment of respiratory complex activities (RCA), to define the frequency of ICUAW in this patient group, and to reach new parameters for early prediction and diagnosis. METHODS: We prospectively recruited twenty-four severe acute stroke patients during a sixteen-month period...
October 2022: Acta Neurologica Belgica
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