keyword
https://read.qxmd.com/read/38313389/safety-and-effectiveness-of-neuromuscular-electrical-stimulation-in-cardiac-surgery-a-systematic-review
#1
JOURNAL ARTICLE
Christos Kourek, Marios Kanellopoulos, Vasiliki Raidou, Michalis Antonopoulos, Eleftherios Karatzanos, Irini Patsaki, Stavros Dimopoulos
BACKGROUND: Lack of mobilization and prolonged stay in the intensive care unit (ICU) are major factors resulting in the development of ICU-acquired muscle weakness (ICUAW). ICUAW is a type of skeletal muscle dysfunction and a common complication of patients after cardiac surgery, and may be a risk factor for prolonged duration of mechanical ventilation, associated with a higher risk of readmission and higher mortality. Early mobilization in the ICU after cardiac surgery has been found to be low with a significant trend to increase over ICU stay and is also associated with a reduced duration of mechanical ventilation and ICU length of stay...
January 26, 2024: World Journal of Cardiology
https://read.qxmd.com/read/38256581/survey-on-nutrition-in-neurological-intensive-care-units-sonnic-a-cross-sectional-survey-among-german-speaking-neurointensivists-on-medical-nutritional-therapy
#2
JOURNAL ARTICLE
Leon Gehri, Moritz L Schmidbauer, Timon Putz, Luka Ratkovic, Andreas Maskos, Cedric Zeisberger, Julia Zibold, Konstantinos Dimitriadis, On Behalf Of The Ignite Study Group
Medical nutritional therapy (MNT) in neurointensive care units (NICUs) is both particularly relevant and challenging due to prolonged analgosedation, immobilization, disorders of consciousness, and the high prevalence of dysphagia. Moreover, current guideline recommendations predominantly address the general intensive care unit (ICU) population, overlooking specific characteristics of neurological patients. We, therefore, conducted a web-based, cross-sectional survey for German-speaking neurointensivists mapping the clinical practices of MNT on NICUs to identify research gaps and common grounds for future clinical trials...
January 13, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38042000/effects-of-structured-protocolized-physical-therapy-on-the-duration-of-mechanical-ventilation-in-patients-with-prolonged-weaning
#3
JOURNAL ARTICLE
Johannes Bickenbach, Sebastian Fritsch, Sophia Cosler, Yvonne Simon, Michael Dreher, Silke Theisen, Joyce Kao, Frank Hildebrand, Gernot Marx, Tim Philipp Simon
PURPOSE: 20% of patients with mechanical ventilation (MV) have a prolonged, complex weaning process, often experiencing a condition of ICU-acquired weakness (ICUAW), with a severe decrease in muscle function and restricted long-term prognosis. We aimed to analyze a protocolized, systematic approach of physiotherapy in prolonged weaning patients and hypothesized that the duration of weaning from MV would be shortened. METHODS: ICU patients with prolonged weaning were included before (group 1) and after (group 2) introduction of a quality control measure of a structured and protocolized physiotherapy program...
April 2024: Journal of Critical Care
https://read.qxmd.com/read/37868784/effects-of-conservative-oxygen-therapy-versus-conventional-oxygen-therapy-on-the-mortality-in-icu-patients-a-meta-analysis
#4
JOURNAL ARTICLE
Xinyu Jiang, Dong Qiu
OBJECTIVE: To compare the effects of conservative oxygen therapy and conventional oxygen therapy on the mortality of critically ill patients in ICU. METHODS: Searching for randomized controlled clinical trials (RCT) on the effect of conservative oxygen therapy and conventional oxygen therapy on the mortality of critically ill patients in computer databases, including PubMed, Embase, Cochrane Library, CNKI, VIP, and Wanfang, with postdate before August 2022. We have two researchers evaluating the quality of the literature included and extracting data as per the inclusion and exclusion criteria and then analyzed it with RevMan 5...
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/37783892/ultrasound-assessment-of-muscle-mass-and-correlation-with-clinical-outcomes-in-critically-ill-patients-a-prospective-observational-study
#5
JOURNAL ARTICLE
Cristian Arvey Guzmán-David, Héctor Andrés Ruiz-Ávila, Diana Alexandra Camargo-Rojas, Claudio Jaime Gómez-Alegría, Edgar Debray Hernández-Álvarez
PURPOSE: Muscular atrophy implies structural and functional alterations related to muscular force production and movement. This condition has been reported to be the main reason for generalized muscle weakness; it reflects the severity of the disease and can have a profound impact on short- and long-term clinical outcomes. The purpose of this study was to determine whether muscle atrophy ultrasound parameters early predict muscle weakness, morbidity, or 28-days mortality. METHODS: This was a prospective, observational single center cohort study...
October 2, 2023: Journal of Ultrasound
https://read.qxmd.com/read/37695737/sepsis-leads-to-impaired-mitochondrial-calcium-uptake-and-skeletal-muscle-weakness-by-reducing-the-micu1-mcu-protein-ratio
#6
JOURNAL ARTICLE
Xuexin Li, Bowen Sun, Jie Li, Wanlin Ye, Mingjuan Li, Fasheng Guan, Songlin Wu, Xuerong Luo, Jianguo Feng, Jing Jia, Xueru Liu, Tao Li, Li Liu
Purpose: Intensive care unit-acquired weakness (ICUAW) is a severe neuromuscular complication that frequently occurs in patients with sepsis. The precise molecular pathophysiology of mitochondrial calcium uptake 1 (MICU1) and mitochondrial calcium uniporter (MCU) in ICUAW has not been fully elucidated. Here, we speculate that ICUAW is associated with MICU1:MCU protein ratio-mediated mitochondrial calcium ([Ca 2+ ] m ) uptake dysfunction. Methods: Cecal ligation and perforation (CLP) was performed on C57BL/6J mice to induce sepsis...
November 1, 2023: Shock
https://read.qxmd.com/read/37692780/development-and-validation-of-a-nomogram-for-predicting-persistent-inflammation-immunosuppression-and-catabolism-syndrome-in-trauma-patients
#7
JOURNAL ARTICLE
Ligang Xu, Zhaofeng Kang, Dongfang Wang, Yukun Liu, Chuntao Wang, Zhanfei Li, Xiangjun Bai, Yuchang Wang
BACKGROUND: Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PIICS) is a significant contributor to adverse long-term outcomes in severe trauma patients. OBJECTIVE: The objective of this study was to establish and validate a PIICS predictive model in severe trauma patients, providing a practical tool for early clinical prediction. PATIENTS AND METHODS: Adult severe trauma patients with an Injury Severity Score (ISS) of ≥16, admitted between October 2020 and December 2022, were randomly divided into a training set and a validation set in a 7:3 ratio...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37658771/post-covid-19-intensive-care-unit-acquired-weakness-compromises-long-term-functional-status
#8
JOURNAL ARTICLE
Débora Schmidt, Ane Glauce Margarites, Letícia Pinto Krás Borges Alvarenga, Priscilla Moliterni Paesi, Gilberto Friedman, Graciele Sbruzzi
OBJECTIVE: The objective of this study was to evaluate the impact of intensive care unit (ICU)-acquired weakness (ICUAW) on the functional independence of patients hospitalized for COVID-19 over 6 months after ICU discharge. METHODS: This was a prospective cohort study that included patients who were admitted to the ICU because of COVID-19 and who were monitored for 6 months after discharge from the ICU via telephone. Patients were evaluated at 3 times (30 days, 3 months, and 6 months after discharge from the ICU) for functional independence for personal care and mobility activities (Barthel Scale), independence for self-care (Katz Index), impact of COVID-19 on functional status (Post-COVID-19 Functional Status Scale [PCFS]), and mobility level (ICU Mobility Scale)...
September 2, 2023: Physical Therapy
https://read.qxmd.com/read/37603954/muscle-strength-and-mobility-of-individuals-with-covid-19-compared-with-non-covid-19-in-intensive-care
#9
JOURNAL ARTICLE
Graziele S Tavares, Cristino C Oliveira, Liliane P S Mendes, Marcelo Velloso
BACKGROUND: Critical illness may affect muscle strength and mobility. OBJECTIVES: To compare muscle strength, mobility, and in intensive care unit (ICU)-acquired weakness (ICUAW) prevalence among individuals with COVID-19 and other critical illnesses; to identify factors associated with muscle strength, mobility, and length of stay in COVID-19; and to determine the Perme Intensive Care Unit Mobility Score (PICUMS) cut-off point for ICUAW. METHODS: We included individuals aged ≥18 in ICU who require mechanical ventilation...
2023: Heart & Lung: the Journal of Critical Care
https://read.qxmd.com/read/37467885/targeting-nat10-protects-against-sepsis-induced-skeletal-muscle-atrophy-by-inhibiting-ros-nlrp3
#10
JOURNAL ARTICLE
Chuntao Wang, Yukun Liu, Yongsheng Zhang, Dongfang Wang, Ligang Xu, Zhanfei Li, Xiangjun Bai, Yuchang Wang
AIMS: To identify N-acetyltransferase 10 (NAT10) and its downstream signaling pathways in myocytes and skeletal muscle, and to investigate its role in inflammation-induced muscle atrophy. MATERIALS AND METHODS: Cecal ligation and puncture models were used to induce sepsis in C57BL/6 mice, which were treated with either a NAT10 inhibitor or a control agent. The therapeutic effect of NAT10 inhibitor was investigated by evaluating the mass, morphology, and molecular characteristics of mouse skeletal muscle...
July 17, 2023: Life Sciences
https://read.qxmd.com/read/37460303/a-predictive-nomogram-for-intensive-care-acquired-weakness-after-cardiopulmonary-bypass
#11
JOURNAL ARTICLE
Fuxiu Zhong, Haoruo Zhang, Yanchun Peng, Xueying Lin, Liangwan Chen, Yanjuan Lin
PURPOSE: Intensive care unit-acquired weakness (ICUAW) affects patient prognosis after cardiopulmonary bypass (CPB) surgery, but its risk factors remain unclear. We investigated these risk factors and developed a nomogram for predicting ICUAW after CPB. METHODS: Baseline characteristics, preoperative laboratory data, and intra- and postoperative variables of 473 patients after CPB were determined in this prospective cohort study. Lower limb muscles on bedside ultrasound images were compared 1 day before and 7 days after CPB...
January 25, 2024: Annals of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/37310449/-intensive-care-unit-acquired-weakness-diagnostic-value-of-neuromuscular-ultrasound
#12
REVIEW
Felix Klawitter, Uwe Walter, Hubertus Axer, Johannes Ehler
Intensive care unit-acquired weakness (ICUAW) is one of the most common neuromuscular complications in intensive care medicine. The clinical diagnosis and assessment of the severity using established diagnostic methods (e.g., clinical examination using the Medical Research Council Sum Score or electrophysiological examination) can be difficult or even impossible, especially in sedated, ventilated and delirious patients. Neuromuscular ultrasound (NMUS) has increasingly been investigated in ICUAW as an easy to use noninvasive and mostly patient compliance-independent diagnostic alternative...
June 13, 2023: Anaesthesiologie
https://read.qxmd.com/read/37285356/enteral-nutrition-management-in-critically-ill-adult-patients-and-its-relationship-with-intensive-care-unit-acquired-muscle-weakness-a-national-cohort-study
#13
JOURNAL ARTICLE
Ignacio Zaragoza-García, Susana Arias-Rivera, María Jesús Frade-Mera, Joan Daniel Martí, Elisabet Gallart, Alicia San José-Arribas, Tamara Raquel Velasco-Sanz, Eva Blazquez-Martínez, Marta Raurell-Torredà
OBJECTIVE: To assess the incidence and determinants of ICU-acquired muscle weakness (ICUAW) in adult patients with enteral nutrition (EN) during the first 7 days in the ICU and mechanical ventilation for at least 48 hours. METHODS: A prospective, nationwide, multicentre cohort study in a national ICU network of 80 ICUs. ICU patients receiving invasive mechanical ventilation for at least 48 hours and EN the first 7 days of their ICU stay were included. The primary outcome was incidence of ICUAW...
2023: PloS One
https://read.qxmd.com/read/37257753/mobilisation-practices-during-the-sars-cov-2-pandemic-a-retrospective-analysis-mobicovid
#14
JOURNAL ARTICLE
Clara M Schellenberg, Maximilian Lindholz, Julius J Grunow, Sebastian Boie, Annika Bald, Linus O Warner, Bernhard Ulm, Annette Milnik, Daniel Zickler, Stefan Angermair, Anett Reißhauer, Martin Witzenrath, Mario Menk, Felix Balzer, Thomas Ocker, Steffen Weber-Carstens, Stefan J Schaller
BACKGROUND: Corona Virus Disease 2019 (COVID-19) patients display risk factors for intensive care unit acquired weakness (ICUAW). The pandemic increased existing barriers to mobilisation. This study aimed to compare mobilisation practices in COVID-19 and non-COVID-19 patients. METHODS: This retrospective cohort study was conducted at Charité-Universitätsmedizin Berlin, Germany, including adult patients admitted to one of 16 ICUs between March 2018, and November 2021...
May 29, 2023: Anaesthesia, Critical Care & Pain Medicine
https://read.qxmd.com/read/37241077/neuromuscular-ultrasound-in-intensive-care-unit-acquired-weakness-current-state-and-future-directions
#15
REVIEW
Felix Klawitter, Uwe Walter, Hubertus Axer, Robert Patejdl, Johannes Ehler
Intensive care unit-acquired weakness (ICUAW) is one of the most common causes of muscle atrophy and functional disability in critically ill intensive care patients. Clinical examination, manual muscle strength testing and monitoring are frequently hampered by sedation, delirium and cognitive impairment. Many different attempts have been made to evaluate alternative compliance-independent methods, such as muscle biopsies, nerve conduction studies, electromyography and serum biomarkers. However, they are invasive, time-consuming and often require special expertise to perform, making them vastly impractical for daily intensive care medicine...
April 27, 2023: Medicina
https://read.qxmd.com/read/37209006/spsb1-mediated-inhibition-of-tgf-%C3%AE-receptor-ii-impairs-myogenesis-in-inflammation
#16
JOURNAL ARTICLE
Yi Li, Niklas Dörmann, Björn Brinschwitz, Melanie Kny, Elisa Martin, Kirsten Bartels, Ning Li, Priyanka Voori Giri, Stefan Schwanz, Michael Boschmann, Susanne Hille, Britta Fielitz, Tobias Wollersheim, Julius Grunow, Stephan B Felix, Steffen Weber-Carstens, Friedrich C Luft, Oliver J Müller, Jens Fielitz
BACKGROUND: Sepsis-induced intensive care unit-acquired weakness (ICUAW) features profound muscle atrophy and attenuated muscle regeneration related to malfunctioning satellite cells. Transforming growth factor beta (TGF-β) is involved in both processes. We uncovered an increased expression of the TGF-β receptor II (TβRII)-inhibitor SPRY domain-containing and SOCS-box protein 1 (SPSB1) in skeletal muscle of septic mice. We hypothesized that SPSB1-mediated inhibition of TβRII signalling impairs myogenic differentiation in response to inflammation...
May 20, 2023: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/37182030/association-between-intensive-care-unit-acquired-weakness-and-early-nutrition-and-rehabilitation-intensity-in-mechanically-ventilated-patients-a-multicenter-retrospective-observational-study
#17
JOURNAL ARTICLE
Shinichi Watanabe, Jun Hirasawa, Yuji Naito, Motoki Mizutani, Akihiro Uemura, Shogo Nishimura, Keisuke Suzuki, Yasunari Morita, Yuki Iida
BACKGROUND: Muscle weakness in the intensive care unit (ICU), referred to as ICU-acquired weakness (ICUAW), is a common complication observed in patients receiving mechanical ventilation. This study aimed to investigate whether rehabilitation intensity and nutrition during ICU admission are associated with the incidence of ICUAW. MATERIALS AND METHODS: Consecutive patients aged ≥18 years who were admitted to the ICU between April 2019 and March 2020 and who received mechanical ventilation for >48 h were eligible...
April 2023: Curēus
https://read.qxmd.com/read/37156115/gut-muscle-axis-and-sepsis-induced-myopathy-the-potential-role-of-gut-microbiota
#18
REVIEW
Yukun Liu, Ligang Xu, Zhaohui Yang, Dongfang Wang, Tianyu Li, Fan Yang, Zhanfei Li, Xiangjun Bai, Yuchang Wang
Sepsis is described as an immune response disorder of the host to infection in which microorganisms play a non-negligible role. Most survivors of sepsis experience ICU-acquired weakness, also known as septic myopathy, characterized by skeletal muscle atrophy, weakness, and irreparable damage/regenerated or dysfunctional. The mechanism of sepsis-induced myopathy is currently unclear. It has been believed that this state is triggered by circulating pathogens and their related harmful factors, leading to impaired muscle metabolism...
July 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/36996359/the-effects-of-early-mobilization-on-acquired-weakness-in-intensive-care-units-a-literature-review
#19
REVIEW
Debora Rosa, Alessandra Negro, Ilaria Marcomini, Roberta Pendoni, Beatrice Albabesi, Giovanni Pennino, Stefano Terzoni, Anne Destrebecq, Giulia Villa
BACKGROUND: Intensive care unit (ICU)-acquired weakness (ICUAW) is defined as a clinical syndrome of neuromuscular weakness, and a consequence of critical illness, unrelated to any other etiology. It is associated with difficult weaning from the ventilator, prolonged ICU stay, increased mortality, and other important long-term outcomes. Early mobilization is defined as any active exercise in which patients use their muscle strength actively or passively within the first 2 to 5 days of critical illness...
May 2023: Dimensions of Critical Care Nursing: DCCN
https://read.qxmd.com/read/36982590/mitochondrial-dysfunction-in-intensive-care-unit-acquired-weakness-and-critical-illness-myopathy-a-narrative-review
#20
REVIEW
Felix Klawitter, Johannes Ehler, Rika Bajorat, Robert Patejdl
Mitochondria are key structures providing most of the energy needed to maintain homeostasis. They are the main source of adenosine triphosphate (ATP), participate in glucose, lipid and amino acid metabolism, store calcium and are integral components in various intracellular signaling cascades. However, due to their crucial role in cellular integrity, mitochondrial damage and dysregulation in the context of critical illness can severely impair organ function, leading to energetic crisis and organ failure. Skeletal muscle tissue is rich in mitochondria and, therefore, particularly vulnerable to mitochondrial dysfunction...
March 14, 2023: International Journal of Molecular Sciences
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