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Skin Lymphomas

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https://www.readbyqxmd.com/read/29469767/eosinophilic-infiltrate-resembling-eosinophilic-cellulitis-wells-syndrome-in-a-patient-with-mycosis-fungoides
#1
Drew A Emge, Daniel J Lewis, Phyu P Aung
Mycosis fungoides (MF) is a T-cell, non-Hodgkin lymphoma that primarily involves the skin. Extracutaneous involvement, such as in the parotidgland, is characteristic of end-stage disease. Eosinophilic cellulitis, or Wells syndrome, is a rare inflammatory dermatitis that involves a dermal infiltrate of eosinophils. We report a case of an 80-year-old man with a long-standing diagnosis of stage IIB MF who acutely developed parotid gland involvement and marked hypereosinophilia that most likely represented eosinophilic cellulitis...
January 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469762/anaplastic-large-cell-lymphoma-localized-to-the-left-breast-years-after-radiotherapy-for-breast-cancer
#2
Michelle S Min, Ali Al-Haseni, Farah Succaria, Lynne Goldberg, Adam Lerner, Debjani Sahni
Anaplastic large cell lymphoma (ALCL) is a rare type of non-Hodgkin lymphoma that can involve the skin primarily or secondarily. Our case describes an unusual presentation of eruptive tumors localized to the leftbreast region several years following breast cancer surgery and radiation for carcinoma of the breast. This report highlights the challenges in reachingthe diagnosis of an aggressive systemic lymphoma presenting on the skin.
January 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469744/folliculin-mutation-negative-trichodiscomas-in-a-patient-with-multiple-endocine-neoplasia-type-i-syndrome
#3
Jennifer E Yeh, Steven R Tahan, Susan Burgin
Mycosis fungoides (MF) is the most common cutaneous T cell lymphoma that involves the oral mucosal. The manifestation of lesions within the oral cavity generally correlates with a poor prognosis. Management of MF includes skin directed therapies and localized radiation treatment, with systemic biologic therapies and chemotherapy used for more advanced stages. The clinical and histologic features of MF in a patient with oral disease are reviewed.
August 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29456853/crizotinib-associated-toxic-epidermal-necrolysis-in-an-alk-positive-advanced-nsclc-patient
#4
Shaoyu Yang, Liming Wu, Xin Li, Jie Huang, Jianbo Zhong, Xueqin Chen
Crizotinib is an oral small-molecule inhibitor of anaplastic lymphoma kinase (ALK) tyrosine-kinase that has been approved for treating patients with advanced echinoderm microtubule associated protein like 4-ALK rearranged non-small-cell lung cancer (NSCLC). Toxic epidermal necrolysis (TEN) is a rare adverse event associated with crizotinib. The present study reported a case of a 75-year-old Chinese male patient with advanced NSCLC with ALK fusion, who developed TEN after 56 days of crizotinib treatment and demised due to this dermatological adverse event...
March 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29456710/mechanism-of-apoptosis-induction-associated-with-erk1-2-upregulation-via-goniothalamin-in-melanoma-cells
#5
Suphakorn Tangchirakhaphan, Sukanda Innajak, Sirinun Nilwarangkoon, Nudjaree Tanjapatkul, Wilawan Mahabusrakum, Ramida Watanapokasin
The present study aimed to investigate the effect of goniothalamin on apoptosis induction in the A375 melanoma cell line. Melanoma is a type of skin cancer with increased prevalence and no potential standard treatment. Goniothalamin is a plant, bioactive styrly-lactone, which has various bioactivities including anti-microbial, anti-inflammatory and anti-cancer. Apoptosis induction by goniothalamin has been studied in numerous cancer cell lines, however not in the melanoma cell line A375. The results of the MTT assay demonstrated that goniothalamin induced anti-proliferation in a dose dependent manner...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456618/an-unusual-presentation-of-adult-t-cell-leukemia-lymphoma
#6
Mohammed Tag-Adeen, Keiichi Hashiguchi, Yuko Akazawa, Ken Ohnita, Sawayama Yasushi, Niino Daisuke, Kazuhiko Nakao
Adult T-cell Leukemia/Lymphoma (ATL) is a rare disease, related to human T-lymphotropic virus-1 (HTLV-1) and presented mainly in adulthood by generalised lymphadenopathy, hepatosplenomegaly, skin lesions and hypercalcaemia, with rare gastrointestinal and/or oral manifestations. We reported this case to raise awareness and demonstrate the therapeutic challenges of this rare disease. A 49-year-old Japanese female presented with skin papules on both forearms, painful mouth ulcers and multiple neck swellings since early February 2017...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29455176/late-diagnosis-a-case-of-rapidly-progressive-extranodal-nk-t-cell-lymphoma-nasal-type
#7
Hiroyuki Mori, Kei Ebisawa, Mitsushige Nishimura, Kenji Kanazawa
Extranodal natural killer (NK)/T cell lymphoma, nasal type is a condition that has poor prognosis. Accurate diagnosis of lymphoma is made by pathological findings. We report a case of extranodal NK/T cell lymphoma, nasal type affecting the lung and liver and which was difficult to diagnose because of negative biopsy results from multiple sites. A 39-year-old man who had dry cough and fever for 1 month was referred to our hospital. He had pancytopenia and elevated serum levels of lactate dehydrogenase and soluble interleukin-2 receptor...
February 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29452667/overview-on-the-management-of-non-gastric-malt-lymphomas
#8
REVIEW
Irene Defrancesco, Luca Arcaini
Extranodal marginal zone B-cell lymphomas (EMZLs) of the mucosa-associated lymphoid tissue (MALT) are indolent lymphomas which can present at any extranodal site. The most frequent localizations (other than stomach) are ocular adnexa, salivary gland, skin, lung and thyroid. Chronic inflammation and antigenic stimulation are a potential risk for the development of MALT lymphomas. While Helicobacter Pylori (HP) is known to be associated with gastric MALT lymphoma and antibiotic therapy is effective in the setting of HP-positive, other microorganisms (such as Chlamydophila Psittaci, Campylobacter Jejiuni, Borrelia Burgdoferi) have been implicated in the pathogenesis of non-gastric MALT lymphomas...
March 2018: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/29450588/response-rates-and-recurrence-patterns-after-low-dose-radiotherapy-with-4-gy-in-patients-with-low-grade-lymphomas
#9
Laila König, Juliane Hörner-Rieber, Denise Bernhardt, Adriane Hommertgen, Stefan Rieken, Jürgen Debus, Klaus Herfarth
PURPOSE: Retrospective study of effectiveness, toxicity, and relapse patterns after low-dose radiotherapy (LDRT) in patients with low-grade lymphomas. METHODS: 47 patients (median age 64 years) with 50 lesions were treated with LDRT (2 × 2 Gy). In 60%, LDRT was the primary and curative treatment, in 40% offered as second-line therapy in recurrent disease. Histology included follicular (57%) and marginal zone lymphomas (43%). Patients were followed-up regularly clinically (skin) and with CT or MRI scans...
February 15, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29449683/adult-t-cell-leukemia-lymphoma-can-be-indistinguishable-from-other-more-common-t-cell-lymphomas-the-university-of-miami-experience-with-a-large-cohort-of-cases
#10
Mahsa Khanlari, Juan Carlos Ramos, Sandra Patricia Sanchez, Jeong Hee Cho-Vega, Alexandra Amador, German Campuzano-Zuluaga, Francisco Vega, Jennifer R Chapman
Adult T-cell leukemia/lymphoma, an aggressive T-cell neoplasm, is causally linked to human T-cell lymphotropic virus type 1 and based on this association has a distinct geographic distribution. In our United States-based practice, whose population is enriched for immigrants from human T-cell lymphotropic virus type 1 endemic areas, we have identified that a subset of adult T-cell leukemia/lymphoma, in the absence of human T-cell lymphotropic virus type 1 identification, are indistinguishable from other more common T-cell neoplasms...
February 15, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29447635/sublamina-densa-type-linear-iga-bullous-dermatosis-with-iga-autoantibodies-specific-for-type-vii-collagen-a-case-report-and-clinicopathological-review-of-32-cases
#11
Natsuko Utsunomiya, Takenao Chino, Noritaka Oyama, Akira Utsunomiya, Yuka Yamaguchi, Wataru Takashima, Atsushi Tokuriki, Minoru Hasegawa
Linear IgA bullous dermatosis (LABD) is a rare autoimmune bullous disorder characterized by linear deposits of IgA at the basement membrane zone(BMZ) and/or by circulating IgA anti-BMZ antibodies. Comparing with other immuno-bullous diseases, LABD represents a heterogeneous disease entitywith diversity of pathogenic IgA autoantibodies to different hemidesmosomal antigens and an association with malignancies and occasional drug use. We herein present an 82-year-old Japanese man with LABD, whose indirect immunofluorescence using 1M NaCl-split skin showed positive staining for IgA at the dermal side alone...
November 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29443697/t-lymphoblastic-leukemia-lymphoma-with-annular-skin-rash-and-epidermotropism
#12
Parisa Mansoori, Arash Taheri, Stacey S OʼNeill, Omar P Sangueza
Leukemia cutis is uncommon in patients with acute lymphoblastic leukemia. It typically presents with dermal papules or subcutaneous nodules, with no epidermal or upper papillary dermal involvement on histopathology. We present an unusual clinical presentation of leukemia cutis, with annular plaques and epidermotropism.
February 7, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29438147/ulcerated-basal-cell-carcinomas-masquerading-as-venous-leg-ulcers
#13
Catherine N Tchanque-Fossuo, Jillian W Millsop, Mary Ann Johnson, Sara E Dahle, R Rivkah Isseroff
BACKGROUND: Nonmelanoma skin cancers rarely arise from venous leg ulcers (VLUs). Although basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer, its association with lower-extremity ulcers is not as frequently reported as other malignancies. OBJECTIVE: To report a case series of biopsy-proven BCC from lower-extremity ulcers of patients who presented at a multispecialty wound clinic. METHODS: Four male patients (mean age, 82...
March 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29435742/information-needs-expressed-during-patient-oriented-oncology-consultations-quantity-variation-and-barriers
#14
Anesa Ahamad, Paul Wallner, Sharon Salenius, Rudi Ross, Eduardo Fernandez
High-quality oncology consultation includes patient-oriented communication tailored to patients' individualized needs. Common methods used in studies to increase question-asking are prompt lists and coaching pre-consultations. However, our patients were encouraged to ask questions by the physician during their visit. We aimed to estimate the quantity, nature, and variation of their questions when they were invited to ask by their oncologist. During radiotherapy consultations from 2012 to 2016, patient's questions were deliberately elicited and physician-transcribed...
February 12, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29428971/emergence-of-anti-mitochondrial-m2-antibody-in-patient-with-angioimmunoblastic-t-cell-lymphoma
#15
Shun-Ichi Wakabayashi, Takefumi Kimura, Naoki Tanaka, Satoru Joshita, Kazuhito Kawata, Takeji Umemura, Yuki Hiroshima, Hiromitsu Mori, Hikaru Kobayashi, Shuichi Wada, Eiji Tanaka
A 68-year-old woman was referred to our hospital due to fever and rash on the neck and extremities. Laboratory findings revealed hepatic dysfunction and positivity for anti-mitochondrial M2 antibody (AMA-M2). Hepatosplenomegaly and systemic lymphadenopathy were detected by enhanced computed tomography. One week after her first visit, hypoxemia, ascites, and Coomb test-positive autoimmune hemolytic anemia had newly appeared in addition to worsened fever, hepatosplenomegaly, and lymphadenopathy. Results of axillary lymph node, skin, and bone-marrow biopsies led to the diagnosis of angioimmunoblastic T-cell lymphoma (AITL), for which CEPP therapy (cyclophosphamide, etoposide, procarbazine, and prednisolone) was initiated...
February 10, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29423555/second-malignancies-after-hematopoietic-stem-cell-transplantation
#16
REVIEW
Ivetta Danylesko, Avichai Shimoni
Second malignancies are a rare but well-defined late complication after autologous and allogeneic hematopoietic stem-cell transplantation (SCT). Solid malignancies occur in up to 15% of patients 15 years after SCT with myeloablative conditioning, with no plateau in the incidence rates. They are responsible for 5-10% of late deaths after SCT. The incidence is increased with advanced age at SCT. The major risk factors are the use of total body irradiation, which is associated with adenocarcinomas and with chronic graft-versus-host disease which is associated with squamous cell cancers...
February 8, 2018: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29422817/current-applications-of-high-frequency-ultrasonography-in-dermatology
#17
REVIEW
Adriana Polańska, Aleksandra Dańczak-Pazdrowska, Magdalena Jałowska, Ryszard Żaba, Zygmunt Adamski
The era of ultrasounds in dermatology started in 1979, when pioneering use of 15 MHz by Alexander and Miller in measuring the skin thickness was introduced. Since then, some new applications of high-frequency ultrasonography (HF-USG) have emerged providing the clinicians with an extra hand in their everyday practice. The main advantages of HF-USG include the possibility of real-time imaging, measurements of morphological and physiological aspects of the skin, safety associated with the use of non-ionizing media as well as the lack of contraindications to its performance...
December 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29422815/the-role-of-regulatory-t-cells-and-genes-involved-in-their-differentiation-in-pathogenesis-of-selected-inflammatory-and-neoplastic-skin-diseases-part-iii-polymorphisms-of-genes-involved-in-tregs-activation-and-function
#18
REVIEW
Bogusław Nedoszytko, Małgorzata Sokołowska-Wojdyło, Joanna Renke, Magdalena Lange, Piotr Trzonkowski, Michał Sobjanek, Aneta Szczerkowska-Dobosz, Marek Niedoszytko, Aleksandra Górska, Jan Romantowski, Jarosław Skokowski, Leszek Kalinowski, Roman J Nowicki
Regulatory T cells (Tregs) represent a cell type that promotes immune tolerance to autologous components and maintains immune system homeostasis. The abnormal function of Tregs is relevant to the pathogenesis of several skin diseases like psoriasis, atopic dermatitis, systemic lupus erythematosus, cutaneous T-cell lymphomas, and skin cancer and is also important in rheumatoid arthritis, diabetes and other autoimmune diseases. In this review, we will summarize the role of mutations and/or polymorphisms of genes involved in Tregs development, and functions in the pathogenesis of selected skin diseases...
December 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29420242/peripheral-t-cell-lymphoma-mimicking-classic-hodgkin-s-lymphoma-in-a-patient-presenting-with-fevers-of-unknown-origin
#19
Caitlin Butler, William Paul Skelton, Arpan Patel, Dhruv Mahtta, Yi Zhuang, Kartik Cherabuddi, Kairav Shah, Merry Markham
A 52-year-old man presented to our hospital for further workup of fever of unknown origin after an extensive workup at an outside hospital had failed to reveal a diagnosis. At the outside hospital, he underwent excisional biopsy of the left supraclavicular lymph node, which showed non-necrotising granulomatous changes, and a bone marrow biopsy which showed a normocellular marrow. He was discharged without a diagnosis with recommendations to present to a tertiary hospital. During his admission, his hospital course was complicated by new direct hyperbilirubinaemia and eosinophilia, prompting liver and skin biopsies which showed CD30+ and CD3+ cells...
February 2, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29419915/skin-manifestations-in-patients-with-hcv-related-chronic-liver-disease
#20
Rosanna Satta, Giovanni Mario Pes, Bianca Maria Quarta Colosso, Maria Pina Dore
Hepatitis C virus (HCV) is able to trigger both hepatic and extra-hepatic manifestations (1,2). Among the latter, the most investigated is mixed cryoglobulinemia vasculitis (MCV), especially of type II (3, 4), usually detected in 40-60% of patients chronically infected with enhanced the risk to develop lymphomas (5). Autoimmune disorders including thyroid disease, and diabetes mellitus have also been associated with chronic HCV infection (6). Skin manifestations may occur in up to 17% of HCV positive patients (7) and are the result of the immuno-mediated damage induced by the virus itself, and/or the associated liver injury (8)...
February 8, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
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