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ApoB/ApoA1 ratio

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https://www.readbyqxmd.com/read/29772479/adverse-lipid-profile-elevates-risk-for-subarachnoid-hemorrhage-a-prospective-population-based-cohort-study
#1
Joni Lindbohm, Miikka Korja, Pekka Jousilahti, Veikko Salomaa, Jaakko Kaprio
BACKGROUND AND AIMS: Studies report that both high and low total cholesterol (TC) elevates SAH risk. There are few prospective studies on high-density lipoproteins (HDL-C) and low-density lipoproteins (LDL-C), and apparently none concerns apolipoproteins A and B. We aimed to clarify the association between lipid profile and SAH risk. METHODS: The National FINRISK study provided risk-factor data recorded at enrolment between 1972 and 2007. During 1.52 million person-years of follow-up until 2014, 543 individuals suffered from incident hospitalized SAH or outside-hospital-fatal SAH...
May 5, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29764762/analysis-of-plasma-albumin-vitamin-d-and-apolipoproteins-a-and-b-as-predictive-coronary-risk-biomarkers-in-the-regicor-study
#2
Gabriel Vázquez-Oliva, Alberto Zamora, Rafel Ramos, Isaac Subirana, María Grau, Irene R Dégano, Daniel Muñoz, Montserrat Fitó, Roberto Elosua, Jaume Marrugat
INTRODUCTION AND OBJECTIVES: New biomarkers could improve the predictive capacity of classic risk functions. The aims of this study were to determine the association between circulating levels of apolipoprotein A1 (apoA1), apolipoprotein B (apoB), albumin, and 25-OH-vitamin D and coronary events and to analyze whether these biomarkers improve the predictive capacity of the Framingham-REGICOR risk function. METHODS: A case-cohort study was designed. From an initial cohort of 5404 individuals aged 35 to 74 years with a 5-year follow-up, all the participants who had a coronary event (n = 117) and a random group of the cohort (subcohort; n = 667) were selected...
May 12, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29747660/association-of-the-apoa1-rs964184-snp-and-serum-lipid-traits-in-the-chinese-maonan-and-han-populations
#3
Ling Qiu, Rui-Xing Yin, Eksavang Khounphinith, Fen-Han Zhang, De-Zhai Yang, Shang-Ling Pan
BACKGROUND: Maonan nationality belongs to a mountain ethnic minority in China. Little is known about the association of apolipoprotein A1 gene (APOA1) rs964184 single nucleotide polymorphism (SNP) and serum lipid levels in this population. The aim of this study was to detect the association of the APOA1 rs964184 SNP and several environmental factors with serum lipid profiles in the Chinese Maonan and Han populations. METHODS: Genotypes of the APOA1 rs964184 SNP in 867 individuals of Maonan nationality and 820 participants of Han nationality were determined by polymerase chain reaction and restriction fragment length polymorphism, combined with gel electrophoresis, and confirmed by direct sequencing...
May 10, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29713185/preoperative-apolipoprotein-b-apolipoprotein-a1-ratio-a-novel-prognostic-factor-for-gastric-cancer
#4
Ming-Zhe Ma, Shu-Qiang Yuan, Yong-Ming Chen, Zhi-Wei Zhou
Background: The correlations between lipid profile (lipid molecules and their derivative indexes) and clinical outcome have been widely testified in many carcinomas, but its prognostic value remains unknown in gastric cancer (GC). Our purpose in the study was to comprehensively evaluate the clinical significance of lipid profile in GC. Methods: We retrospectively collected clinical information of 1,201 GC patients who received surgery at Sun Yat-sen University Cancer Center from 2005 to 2010...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29712560/cardiovascular-disease-risk-factor-responses-to-a-type-2-diabetes-care-model-including-nutritional-ketosis-induced-by-sustained-carbohydrate-restriction-at-1-year-an-open-label-non-randomized-controlled-study
#5
Nasir H Bhanpuri, Sarah J Hallberg, Paul T Williams, Amy L McKenzie, Kevin D Ballard, Wayne W Campbell, James P McCarter, Stephen D Phinney, Jeff S Volek
BACKGROUND: Cardiovascular disease (CVD) is a leading cause of death among adults with type 2 diabetes mellitus (T2D). We recently reported that glycemic control in patients with T2D can be significantly improved through a continuous care intervention (CCI) including nutritional ketosis. The purpose of this study was to examine CVD risk factors in this cohort. METHODS: We investigated CVD risk factors in patients with T2D who participated in a 1 year open label, non-randomized, controlled study...
May 1, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29627296/relationship-between-lipoprotein-subfraction-cholesterol-and-residual-risk-for-cardiovascular-outcomes-a-post-hoc-analysis-of-the-aim-high-trial
#6
Peter P Toth, Steven R Jones, April Slee, Jerome Fleg, Santica M Marcovina, Megan Lacy, Ruth McBride, William E Boden
BACKGROUND: The AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides and Impact on Global Health Outcomes) trial failed to demonstrate incremental clinical benefit of extended-release niacin (ERN) in 3414 statin-treated patients with established cardiovascular (CV) disease who had low baseline levels of high-density lipoprotein cholesterol (HDL-C) as compared to placebo. A previous secondary analysis suggested that ERN provided outcome benefits in ERN-treated patients with high triglycerides (TGs; >200 mg/dL) and very low HDL-C (<32 mg/dL) at baseline...
March 9, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29602595/lipid-and-lipoprotein-parameters-for-detection-of-familial-hypercholesterolemia-in-childhood-the-decopin-project
#7
Núria Plana, Cèlia Rodríguez-Borjabad, Daiana Ibarretxe, Raimon Ferré, Albert Feliu, Alejandra Caselles, Luis Masana
BACKGROUND: Familial hypercholesterolaemia (FH) in children is under-detected and is difficult to diagnose in clinical practice. The aim of this study was to evaluate clinical, biochemical and vascular imaging variables in order to detect children and adolescents with FH. METHODS: A total of 222 children aged 4-18 years old were recruited to participate in a project for the early detection of FH (The DECOPIN Project). They were distributed into 3groups: FH, if genetic study or clinical criteria were positive (n=91); Polygenic hypercholesterolaemia (PH) if LDL-Cholesterol >135mg/dL without FH criteria (n=23), and Control group (CG) if LDL-C <135mg/dL (n=108)...
March 27, 2018: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/29484343/association-of-spicy-food-consumption-frequency-with-serum-lipid-profiles-in-older-people-in-china
#8
K Yu, Y Xue, T He, L Guan, A Zhao, Y Zhang
OBJECTIVES: There has been recent interest in spicy foods and their bioactive ingredients for cardiovascular health. This study aims to explore relationship between spicy food consumption frequency and serum lipid profiles in a cross-sectional sample of older Chinese from China Health and Nutrition Survey (CHNS). METHODS: A total of 1549 participant aged 65 years and above from CHNS 2009 were included in the analysis. Information on spicy food consumption was obtained using a questionnaire survey and 24h dietary recalls over three consecutive days combined with weighted food inventory...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29478422/lower-vitamin-d-intake-is-associated-with-low-hdl-cholesterol-and-vitamin-d-insufficiency-deficiency-in-brazilian-children
#9
Mariana De Santis Filgueiras, Lara Gomes Suhett, Mariane Alves Silva, Naruna Pereira Rocha, Juliana Farias de Novaes
OBJECTIVE: To evaluate the association of vitamin D intake with dyslipidaemia and vitamin D insufficiency/deficiency in Brazilian children and identify the main food group sources of this nutrient in the sample. DESIGN: A cross-sectional study carried out with a representative sample. Blood was collected after 12 h of fasting. Laboratory tests were performed to determine total cholesterol, HDL cholesterol (HDL-C), LDL cholesterol, TAG, apoB, apoA1, 25-hydroxyvitamin D and parathyroid hormone...
February 26, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29438687/increased-apob-apoa1-ratio-is-associated-with-excess-weight-body-adiposity-and-altered-lipid-profile-in-children
#10
Ana Paula Pereira Castro, Helen Hermana Miranda Hermsdorff, Luana Cupertino Milagres, Fernanda Martins de Albuquerque, Mariana De Santis Filgueiras, Naruna Pereira Rocha, Juliana Farias de Novaes
OBJECTIVE: To investigate ApoB/ApoA1 ratio and its association with cardiovascular risk factors in children. METHODS: Cross-sectional study with 258 children aged 8 and 9 years old, enrolled in all urban schools in the city of Viçosa-MG. Anthropometric and body composition assessment, as well as biochemical profile of the children was performed. Socioeconomic variables and sedentary lifestyle were evaluated through a semi-structured questionnaire. RESULTS: Many children had excess weight (35...
February 10, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/29419390/dyslipidemia-and-risk-of-cardiovascular-events-in-patients-with-atrial-fibrillation-treated-with-oral-anticoagulation-therapy-insights-from-the-aristotle-apixaban-for-reduction-in-stroke-and-other-thromboembolic-events-in-atrial-fibrillation-trial
#11
Tymon Pol, Claes Held, Johan Westerbergh, Johan Lindbäck, John H Alexander, Marco Alings, Cetin Erol, Shinya Goto, Sigrun Halvorsen, Kurt Huber, Michael Hanna, Renato D Lopes, Witold Ruzyllo, Christopher B Granger, Ziad Hijazi
BACKGROUND: Dyslipidemia is a major risk factor for cardiovascular events. The prognostic importance of lipoproteins in patients with atrial fibrillation is not well understood. We aimed to explore the association between apolipoprotein A1 (ApoA1) and B (ApoB) and cardiovascular events in patients with atrial fibrillation receiving oral anticoagulation. METHODS AND RESULTS: Using data from the ARISTOTLE (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation) trial, ApoA1 and ApoB plasma levels were measured at baseline in 14 884 atrial fibrillation patients...
February 1, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29371971/association-between-the-pinx1-and-nat2-polymorphisms-and-serum-lipid-levels
#12
Qing-Hui Zhang, Rui-Xing Yin, Feng Huang, De-Zhai Yang, Wei-Xiong Lin, Shang-Ling Pan
Jing nationality is a relatively conservative and isolated minority in China. Little is known about the association of the PIN2/TERF1-interacting telomerase inhibitor 1 ( PINX1 ) and N-acetyltransferase 2 ( NAT2 ) single nucleotide polymorphisms (SNPs) and serum lipid levels in the Chinese populations. This study aimed to clarify the association of 6 SNPs of the PINX1 and NAT2 and serum lipid levels in two Chinese populations. Genotyping of the SNPs was performed in 1236 Han subjects and 1248 Jing participants...
December 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/29366170/apob-apoa1-ratio-and-apoc2-are-the-best-biomarkers-to-distinguish-familial-hypercholesterolemia-from-other-dyslipidaemia
#13
Ana Margarida Medeiros, Ana Catarina Alves, Mafalda Bourbon
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29312456/association-of-sleep-duration-with-apolipoproteins-and-the-apolipoprotein-b-a1-ratio-the-china-health-and-nutrition-survey
#14
Huihui Ren, Zhelong Liu, Xinrong Zhou, Gang Yuan
Background: Short sleep duration has been related to established cardiovascular risk factors, likely obesity, diabetes, hypertension and dyslipidaemia. However, to the best of our knowledge, the associations between sleep duration and apolipoprotein concentrations and their ratios have not been investigated to date. This study aimed to explore the independent relationship of sleep duration with apolipoprotein (apo) A1, apoB and the apoB/apoA1 ratio in a Chinese adult population. Methods: Data from 7381 participants, aged 18 to 75 years, from the National Health and Nutrition Survey 2009 were analysed in this cross-sectional study...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29311405/worsening-of-serum-lipid-profile-after-direct-acting-antiviral-treatment
#15
Stefano Gitto, Arrigo F G Cicero, Elisabetta Loggi, Marina Giovannini, Fabio Conti, Elena Grandini, Valeria Guarneri, Alessandra Scuteri, Giovanni Vitale, Carmela Cursaro, Claudio Borghi, Pietro Andreone
INTRODUCTION: Host lipid metabolism influences viral replication and lifecycle of hepatitis C virus. Our aim was to evaluate changes in glucose and lipid metabolism of patients with chronic hepatitis C after therapy with direct acting antivirals (DAA). MATERIAL AND METHODS: We considered patients consecutively treated between January and November 2015 recording clinical data at baseline and week 24 of follow-up. Frozen serum samples were used for apolipoprotein A1 (apoA1), apolipoprotein B (apoB) and lipoprotein (a) [Lp(a)]...
January 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29146227/bariatric-surgery-improves-lipoprotein-profile-in-morbidly-obese-patients-by-reducing-ldl-cholesterol-apob-and-saa-pon1-ratio-increasing-hdl-cholesterol-but-has-no-effect-on-cholesterol-efflux-capacity
#16
Christian Abendstein Kjellmo, Helen Karlsson, Torunn K Nestvold, Stefan Ljunggren, Karin Cederbrant, Maritha Marcusson-Ståhl, Monica Mathisen, Knut Tore Lappegård, Anders Hovland
BACKGROUND: Bariatric surgery has been shown to reduce cardiovascular events and cause-specific mortality for coronary artery disease in obese patients. Lipoprotein biomarkers relating to low-density lipoprotein (LDL), high-density lipoprotein (HDL), their subfractions, and macrophage cholesterol efflux have all been hypothesized to be of value in cardiovascular risk assessment. OBJECTIVES: The objective of this study was to examine the effect of a lifestyle intervention followed by bariatric surgery on the lipid profile of morbidly obese patients...
January 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29145892/association-between-plasma-phospholipid-saturated-fatty-acids-and-metabolic-markers-of-lipid-hepatic-inflammation-and-glycaemic-pathways-in-eight-european-countries-a-cross-sectional-analysis-in-the-epic-interact-study
#17
Ju-Sheng Zheng, Stephen J Sharp, Fumiaki Imamura, Albert Koulman, Matthias B Schulze, Zheng Ye, Jules Griffin, Marcela Guevara, José María Huerta, Janine Kröger, Ivonne Sluijs, Antonio Agudo, Aurelio Barricarte, Heiner Boeing, Sandra Colorado-Yohar, Courtney Dow, Miren Dorronsoro, Pia T Dinesen, Guy Fagherazzi, Paul W Franks, Edith J M Feskens, Tilman Kühn, Verena Andrea Katzke, Timothy J Key, Kay-Tee Khaw, Maria Santucci de Magistris, Francesca Romana Mancini, Elena Molina-Portillo, Peter M Nilsson, Anja Olsen, Kim Overvad, Domenico Palli, Jose Ramón Quirós, Olov Rolandsson, Fulvio Ricceri, Annemieke M W Spijkerman, Nadia Slimani, Giovanna Tagliabue, Anne Tjonneland, Rosario Tumino, Yvonne T van der Schouw, Claudia Langenberg, Elio Riboli, Nita G Forouhi, Nicholas J Wareham
BACKGROUND: Accumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic diseases, but evidence about associations of SFAs with metabolic markers of different pathogenic pathways is limited. We aimed to examine the associations between plasma phospholipid SFAs and the metabolic markers of lipid, hepatic, glycaemic and inflammation pathways. METHODS: We measured nine individual plasma phospholipid SFAs and derived three SFA groups (odd-chain: C15:0 + C17:0, even-chain: C14:0 + C16:0 + C18:0, and very-long-chain: C20:0 + C22:0 + C23:0 + C24:0) in individuals from the subcohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study across eight European countries...
November 17, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29108969/dietary-butylated-hydroxytoluene-improves-lipid-metabolism-antioxidant-and-anti-apoptotic-response-of-largemouth-bass-micropterus-salmoides
#18
L L Yu, H H Yu, X F Liang, N Li, X Wang, F H Li, X F Wu, Y H Zheng, M Xue, X F Liang
A 10-week growth trail was conducted to investigate the efficacy and tolerance of dietary butylated hydroxytoluene (BHT) by evaluating inflammation, apoptosis and hepatic disease related to oxidative stress in largemouth bass (Micropterus salmoides). Four experimental diets were prepared with BHT supplement levels of 0 (B0), 150 (B150), 300 (B300) and 1500 (B1500) mg/kg, in which B150 was at the maximum recommended level established by European Union Regulation, and the B300 and B1500 levels were 2 and 10-fold of B150, respectively...
January 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29024428/heat-shock-protein-60-in-obesity-effect-of-bariatric-surgery-and-its-relation-to-inflammation-and-cardiovascular-risk
#19
Henrike Sell, Christine Poitou, Christiane Habich, Jean-Luc Bouillot, Jürgen Eckel, Karine Clément
OBJECTIVE: Heat shock protein 60 (Hsp60) is an adipokine, and its serum concentrations are higher in patients with obesity compared to lean patients. This study aimed to analyze the effect of bariatric surgery on circulating concentrations of Hsp60 in morbid obesity and their correlation with inflammation and metabolic and cardiovascular risk. METHODS: Fifty-three females with morbid obesity undergoing bariatric surgery were enrolled. Serum parameters and anthropometric measures were obtained at baseline and 3 to 12 months post surgery...
December 2017: Obesity
https://www.readbyqxmd.com/read/28912560/the-srgap2-snps-their-haplotypes-and-g%C3%A2-%C3%A3-%C3%A2-e-interactions-on-serum-lipid-traits
#20
Liu Miao, Rui-Xing Yin, Jin-Zhen Wu, Shuo Yang, Wei-Xiong Lin, Shang-Ling Pan
Maonan nationality is a relatively conservative and isolated minority in China. Little is known about the association of the Slit-Robo Rho GTPase activating protein 2 gene (SRGAP2) single nucleotide polymorphisms (SNPs) and serum lipid levels in the Chinese populations. This study was performed to clarify the association of the SRGAP2 rs2483058 and rs2580520 SNPs and their haplotypes with serum lipid traits in the Maonan and Han populations. Genotyping of the 2 SNPs was performed in 2444 unrelated subjects (Han, 1210 and Maonan, 1234) by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis, and then confirmed by direct sequencing...
September 14, 2017: Scientific Reports
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