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ApoB/ApoA1 ratio

Ana Claudia Gomes Pereira Petisco, Jorge Eduardo Assef, Carlos Alberto de Jesus, Mohamed Hassan Saleh, Jose Eduardo Martins Barbosa, David Costa de Souza Le Bihan, Ibraim Masciarelli França Pinto, Simone Rolim Fernandes Fontes Pedra, Rodrigo Bellio de Mattos Barretto, Amanda Guerra de Moraes Rego Sousa
Cardiovascular diseases are the leading cause of mortality among women in several countries. Early detection of subclinical atherosclerosis (SA) could enable the adoption of preventive measures to avoid cardiovascular events. This study aimed to determine the prevalence of SA in Brazilian asymptomatic postmenopausal women in Framingham Risk Score (FRS) low and intermediate groups. Computed tomography (CT) and ultrasound (US) scans were performed in 138 asymptomatic postmenopausal women (56.1 ± 4.9 years of age) to survey for coronary artery and aortic calcification (CT scan) and assess carotid intima-media thickness (CIMT) and identify carotid plaques (US)...
October 20, 2016: International Journal of Cardiovascular Imaging
Brian Stegman, Mingyuan Shao, Stephen J Nicholls, Mohamed Elshazly, Leslie Cho, Peta King, Samir Kapadia, Murat Tuzcu, Steven E Nissen, Rishi Puri
BACKGROUND AND AIMS: High-intensity statin therapy (HIST) reduces cardiovascular events, however, sex-related differences in treatment effects are not well characterized. METHODS: A patient-level post hoc pooled analysis of 3 randomized trials utilizing serial coronary intravascular ultrasound was undertaken, testing the anti-atherosclerotic effects of HIST in coronary disease patients. Sex-related differences in changes (Δ) in coronary percent atheroma volume (PAV) were ascertained following 18-24 months of HIST (atorvastatin 80 mg or rosuvastatin 40 mg daily), and further characterized according to on-treatment lipid and lipoprotein levels...
September 15, 2016: Atherosclerosis
Maria Adamarczuk-Janczyszyn, Aleksandra Zdrojowy-Wełna, Natalia Rogala, Katarzyna Zatońska, Grażyna Bednarek-Tupikowska
BACKGROUND: Subclinical hypothyroidism (SCH) is a common endocrine disorder, probably increasing cardiovascular (CV) risk. However, the relation between SCH and atherosclerosis risk factors remains unclear. OBJECTIVES: The aim of the study was to evaluate selected atherosclerosis risk factors in women with SCH in comparison to a group of healthy women and women with overt hypothyroidism, as well as to investigate the influence of L-thyroxine replacement on those risk factors...
May 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Anne Weiland, Achim Bub, Stephan W Barth, Juergen Schrezenmeir, Maria Pfeuffer
The present study examined the effect of milk phospholipids (milk-PL) on lipid metabolism and on other risk factors for CVD, in comparison with milk fat (control) or soya phospholipids (soya-PL), respectively. Two double-blind parallel-group intervention trials were conducted in overweight or obese male subjects. In the first trial (trial 1), sixty-two men consumed milk enriched with either 2 g milk-PL or 2 g milk fat (control) for 8 weeks. In trial 2, fifty-seven men consumed milk enriched with either 3 g milk-PL or 2·8 g soya-PL for 7 weeks...
2016: Journal of Nutritional Science
Yanqiang Wang, Zhengqi Lu, Shaoyang Sun, Yu Yang, Bingjun Zhang, Zhuang Kang, Xueqiang Hu, Yongqiang Dai
BACKGROUND: The association between topographic patterns, risk factors and stroke mechanisms of ICAS in patients with first-ever stroke remains unknown. METHODS: A large sample sized retrospective study was performed on first-ever ICAS-related ischemic stroke using DWI and MRA. Ischemic patterns were categorized as single (corticosubcortical, cortical, subcortical lesion), scattered, multiple lesions. RESULTS: Hypertension (60.92%), cigarette smoking (26...
May 11, 2016: International Journal of Neuroscience
Peter Graversen, Steen Z Abildstrøm, Lasse Jespersen, Anders Borglykke, Eva Prescott
AIM: European society of cardiology (ESC) guidelines recommend that cardiovascular disease (CVD) risk stratification in asymptomatic individuals is based on the Systematic Coronary Risk Evaluation (SCORE) algorithm, which estimates individual 10-year risk of death from CVD. We assessed the potential improvement in CVD risk stratification of 19 easily available risk markers by adding them to the SCORE algorithm. METHODS AND RESULTS: We followed 8476 individuals without prior CVD or diabetes from the Copenhagen City Heart study...
September 2016: European Journal of Preventive Cardiology
Gerhard W Naerr, Philipp Rein, Christoph H Saely, Heinz Drexel
BACKGROUND: Dyslipidemia in rheumatoid arthritis (RA) patients is frequently observed, and treatment with anti-rheumatic drugs has an impact on lipid profiles. Pathophysiologically, inflammation leads to decreased blood lipids and lipoproteins; RA treatment reduces inflammation and therefore may increase lipids and lipoproteins. Whether the lipid changes with RA treatment confer an increased risk of cardiovascular disease or just reflect their potentially atheroprotective anti-inflammatory effect is currently unclear due to limited and conflicting data...
June 2016: Vascular Pharmacology
Ji Soo Oh, Hyesook Kim, Aswathy Vijayakumar, Oran Kwon, Young Ju Choi, Kap Bum Huh, Namsoo Chang
BACKGROUND/OBJECTIVES: This study was aimed at examining the association between dietary flavanones intake and lipid profiles according to the presence of metabolic syndrome (MetS) in Korean women with type 2 diabetes mellitus (T2DM). SUBJECTS/METHODS: A cross-sectional analysis was performed among 502 female T2DM patients (non-MetS group; n = 129, MetS group; n = 373) who were recruited from the Huh's Diabetes Clinic in Seoul, Korea between 2005 and 2011. The dietary intake was assessed by a validated semi-quantitative food frequency questionnaire (FFQ) and the data was analyzed using the Computer Aided Nutritional Analysis program (CAN-Pro) version 4...
February 2016: Nutrition Research and Practice
Yan Zhang, Cheng-Gang Zhu, Yuan-Lin Guo, Sha Li, Rui-Xia Xu, Qian Dong, Jian-Jun Li
BACKGROUND: It has been proposed that plasma fibrinogen is associated with lipid levels and increased cardiovascular risk. However, the interrelationship has not been well-elucidated. We hypothesise that lipids may be potential mediators. METHODS: We enrolled 4748 consecutive subjects scheduled for coronary angiography in this study. The severity of coronary atherosclerosis was assessed by Gensini score (GS). By principle component analysis, a multi-marker lipid index was extracted weighting the coefficients of six atherogenic lipid parameters: total cholesterol (TC), low-density lipoprotein-cholesterol, non-high-density lipoprotein-cholesterol (non-HDL-C), apolipoprotein (apo) B, apoB/apoA1, and TC/HDL-C ratio...
June 2016: Heart, Lung & Circulation
Chao-Wu Xiao, Carla M Wood, Eleonora Swist, Reiko Nagasaka, Kurtis Sarafin, Claude Gagnon, Lois Fernandez, Sylvie Faucher, Hong-Xing Wu, Laura Kenney, Walisundera M N Ratnayake
OBJECTIVES: This study compared cardio-metabolic disease risk factors and their associations with serum vitamin D and omega-3 status in South Asian (SAC) and White Canadians (WC) living in Canada's capital region. METHODS: Fasting blood samples were taken from 235 SAC and 279 WC aged 20 to 79 years in Ottawa, and 22 risk factors were measured. RESULTS: SAC men and women had significantly higher fasting glucose, insulin, homeostasis model assessment for insulin resistance (HOMA-IR), apolipoprotein B (ApoB), ratios of total (TC) to HDL cholesterol (HDLC) and ApoB to ApoA1, leptin, E-selectin, P-selectin, ICAM-1 and omega-3 (p < 0...
2016: PloS One
Signe Borgquist, Talha Butt, Peter Almgren, Dov Shiffman, Tanja Stocks, Marju Orho-Melander, Jonas Manjer, Olle Melander
The epidemiological evidence for an obesity-cancer association is solid, whereas the association between obesity-associated lipoprotein levels and cancer is less evident. We investigated circulating levels of Apolipoprotein A1 (ApoA1), Apolipoprotein B (ApoB), LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) and association to risk of overall cancer and common cancer forms. The Malmö Diet and Cancer Study, a population-based prospective cohort study, enrolled 17,035 women and 11,063 men (1991-1996). Incident cancer cases were ascertained by record linkage with the Swedish Cancer Registry until end of follow-up, January 1, 2012...
June 1, 2016: International Journal of Cancer. Journal International du Cancer
Luiz Gustavo Marin Emed, Daniela Gunther Passaglia, Surya T Guerios, Paula G D João, André I S Moser, Dulcinéia S P Abdalla, Luis Cesar Guarita-Souza, Emanuella Stella Mikilita, Cristina Pellegrino Baena, Ana Beatriz Brenner Affonso da Costa, José Rocha Faria-Neto
We aimed to evaluate the effects of a 24-h ultramarathon, an aerobic test of high physical load, on lipid profile and apolipoproteins B (ApoB) and A1 (ApoA1) levels, minimally modified low-density lipoprotein (LDL), and oxidised LDL. Prospective evaluation of 16 male athletes who participated in an ultramarathon run, where the objective was to run the greatest distance possible in 24 h. Fourteen participants completed the run. The mean distance achieved was 133.1 km (maximum of 169.6 km). There was a trend in reduction of triglycerides and total cholesterol (P = 0...
September 2016: Journal of Sports Sciences
Monika Rać, Andrzej Krzystolik, Michał Rać, Krzysztof Safranow, Violetta Dziedziejko, Marta Goschorska, Wojciech Poncyljusz, Dariusz Chlubek
BACKGROUND: CD36 is a major macrophage scavenger receptor for oxidised low-density lipoprotein particles. Soluble CD36 (sCD36) is circulating as a ligand-bound complex and may be present in microparticles shed from cells such as platelets, monocytes/macrophages, or adipocytes. Positive association of plasma sCD36 with insulin resistance has been reported, and it has been proposed that sCD36 might represent a marker of macrophage activation and inflammation leading to atherosclerosis. Recently we have identified an association between CD36 polymorphism and low thickness of atheromatous plaque, suggesting its protective effect against atherosclerosis development...
2016: Kardiologia Polska
Yuan Wang, Yuju Cao, Yizhou Li, Yongchang Guo, Quanjian Wang, Min Yang, Ning Zhang, Tianbo Jin, Jianzhong Wang
Polymorphisms of apolipoprotein B (ApoB), apolipoprotein A1 (ApoA1) gene and ApoB/ApoA1 Ratio were associated with lipid metabolism disorders in previous reports. The aim of this study assess whether variation of ApoB, ApoA1 gene are associated or not with alcohol-induced osteonecrosis of femoral head (ONFH). In a case-control study, we genotyped 4 single-nucleotide polymorphisms (SNPs) in ApoB and ApoA1 genes in 209 alcohol-induced ONFH patients and 300 healthy control subjects in Han Chinese population using χ(2) test and genetic model analysis...
2015: International Journal of Clinical and Experimental Pathology
Tzortzis Nomikos, Demosthenes Panagiotakos, Ekavi Georgousopoulou, Vassiliki Metaxa, Christina Chrysohoou, Ioannis Skoumas, Smaragdi Antonopoulou, Dimitrios Tousoulis, Christodoulos Stefanadis, Christos Pitsavos
BACKGROUND: The traditional view on the relationship between lipid biomarkers and CVD risk has changed during the last decade. However, it is not clear whether novel lipid biomarkers are able to confer a better predictability of CVD risk, compared to traditional ones.Under this perspective, the aim of the present work was to evaluate the predictive ability of blood lipids' profile on all cause mortality as well as 10-year incidence of CVD, in a sample of apparently healthy adults of the ATTICA epidemiological study...
2015: Lipids in Health and Disease
Hongli Dong, Wei Chen, Xiangyu Wang, Fuhua Pi, Yubin Wu, Shaojie Pang, Yuqing Xie, Fangfang Xia, Qingying Zhang
The associations of levels of apolipoprotein A1 (ApoA1) and apolipoprotein B and ApoB/A1 ratio and risk of a first stroke have not been reliably documented. We performed a meta-analysis to summarize the relationships and confirmed them in a case-control study. We identified relevant publications in PubMed and Embase databases up to June 1, 2015. A Dersimonian-Laird random effects model was used to compute summary relative risks (RRs) and 95 % confidence intervals (CIs). A case-control study was conducted in a southern Chinese population...
December 2015: Metabolic Brain Disease
I Kralova Lesna, J Rychlikova, L Vavrova, S Vybiral
The impact of repeated exposure to cold and cold adaptation on human cardiovascular health is not fully understood. The aim of the study was to determine the effect of cold adaptation on cardiovascular risk factors, thyroid hormones and the capacity of humans to reset the damaging effect of oxidative stress. Ten well cold-adapted winter swimmers (CA) and 16 non-adapted controls (CON) were enroled in this experiment to test whether cold adaptation could influence the parameters of lipoprotein metabolism, cholesterol efflux capacity (CEC), homocysteine, thyroid hormones, antioxidant defence markers (reduced glutathione (GSH), glutathione peroxidase 1 (GPX1), glutathione reductase (GR), catalase (CAT) and paraoxonase 1 (PON1)) and oxidative stress markers (concentration of conjugated dienes (CD))...
August 2015: Journal of Thermal Biology
Tao Guo, Rui-Xing Yin, Hui Li, Yi-Ming Wang, Jin-Zhen Wu, De-Zhai Yang
The objective of the present study was to detect the association of the Trp316Ser variant (rs1801690) near the apolipoprotein H (β2-glycoprotein-I) gene and serum lipid levels in the Mulao and Han populations. A total of 879 subjects of Mulao and 844 subjects of Han Chinese were included. The levels of serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and ApoA1 in Mulao, and triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), ApoA1 and the ratio of ApoA1/ApoB in Han were different among the three genotypes of the rs1801690 SNP (P < 0...
2015: International Journal of Clinical and Experimental Pathology
Eveline P van Poelgeest, Michael R Hodges, Matthijs Moerland, Yann Tessier, Arthur A Levin, Robert Persson, Marie W Lindholm, Kamille Dumong Erichsen, Henrik Ørum, Adam F Cohen, Jacobus Burggraaf
AIMS: LDL-receptor expression is inhibited by the protease proprotein convertase subtilisin/kexin type 9 (PCSK9), which is considered a pharmacological target to reduce LDL-C concentrations in hypercholesterolaemic patients. We performed a first-in-human trial with SPC5001, a locked nucleic acid antisense inhibitor of PCSK9. METHODS: In this randomized, placebo-controlled trial, 24 healthy volunteers received three weekly subcutaneous administrations of SPC5001 (0...
December 2015: British Journal of Clinical Pharmacology
Li Chunming, Sheng Jianhui, Zhang Hongguang, Qiu Chunwu, Huang Xiaoyun, Yang Lijun, Yu Xuejun
BACKGROUND/AIMS: To develop a clinical score for the prediction of nonalcoholic steatohepatitis (NASH) using routine parameters in patients with nonalcoholic fatty liver disease who had abnormal liver function tests and/or fatty liver detected by ultrasonography. MATERIALS AND METHODS: To identify parameters associated with the presence of NASH by evaluating anthropometric characteristics and routine biomarkers of 82 patients with histologically proven NAFLD and to develop a clinical score for predicting NASH according to the area under the curve of receiver operating characteristics (AUC) of parameters...
September 2015: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
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