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JOURNAL ARTICLE
Saba Yasir, Zongming Eric Chen, Chris Hartley, Lizhi Zhang, Michael Torbenson
The classic findings have been well described for light-chain amyloid involving the liver. In addition to light chain, however, many additional proteins are now known to be amyloidogenic and can involve the liver. A total of 58 surgical pathology specimens with amyloid deposits were analyzed for patterns of amyloid deposition, including amyloid from light chain lambda (N = 17), light chain kappa (N = 15), transthyretin (N = 15), serum amyloid A (N = 4), apolipoprotein A1 (N = 4), fibrinogen alpha (N = 2), LECT2 (N = 1)...
March 7, 2024: Human Pathology
#22
JOURNAL ARTICLE
Tommy H T Wong, Jacky M Y Mo, Mingqi Zhou, Jie V Zhao, C Mary Schooling, Baoting He, Shan Luo, Shiu Lun Au Yeung
We assessed the causal relation of four glycemic traits and type 2 diabetes liability with 167 metabolites using Mendelian randomization with various sensitivity analyses and a reverse Mendelian randomization analysis. We extracted instruments for fasting glucose, 2-h glucose, fasting insulin, and glycated hemoglobin from the Meta-Analyses of Glucose and Insulin-related traits Consortium (n = 200,622), and those for type 2 diabetes liability from a meta-analysis of multiple cohorts (148,726 cases, 965,732 controls) in Europeans...
March 8, 2024: Communications Biology
#23
JOURNAL ARTICLE
Jiawen Lu, Zhenqian Wang, Jiaying Zhang, Feng Jiao, Chenfeng Zou, Liyuan Han, Guozhi Jiang
Dyslipidemia has long been implicated in elevating mortality risk; yet the precise associations between lipid traits and mortality remained undisclosed. Our study aimed to explore the causal effects of lipid traits on both all-cause and cause-specific mortality. One-sample Mendelian randomization (MR) with linear and nonlinear assumptions was conducted in a cohort of 407,951 European participants from the UK Biobank. Six lipid traits, consisting of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), and lipoprotein(a), were included to investigate the causal associations with mortality...
March 6, 2024: Journal of Lipid Research
#24
JOURNAL ARTICLE
Huijuan Kou, Hongtao Wang, Peng Liu, Xin Wang, Wenjing Zhu, Wei Jiang, Xiaojun Hu, Jie Deng
BACKGROUND: Familial hypercholesterolemia (FH) is an autosomal semi-dominant disease, characterized by markedly elevated levels of low-density lipoprotein cholesterol (LDL-c) from conception and accelerated atherosclerotic cardiovascular disease, often resulting in early death. The aim of this study was to evaluate the prevalence of clinically defined FH in Chinese Han patients with acute coronary syndrome (ACS) and compare the long-term prognosis of ACS patients with and without FH receiving lipid-lowering therapy containing statins after a coronary event...
March 5, 2024: BMC Cardiovascular Disorders
#25
JOURNAL ARTICLE
Hongzhi Wu, Jiajun Xie, Weiqi Peng, Fengjie Ji, Jinyu Qian, Qian Shen, Guanyu Hou
Exogenous supplementation of guanidinoacetic acid can mechanistically regulate the energy distribution in muscle cells. This study aimed to investigate the effects of guanidinoacetic acid supplementation on liver and breast muscle fat deposition, lipid levels, and lipid metabolism-related gene expression in ducks. We randomly divided 480 42 days-old female Jiaji ducks into four groups with six replicates and 20 ducks for each replicate. The control group was fed the basal diet, and the experimental groups were fed the basal diet with 400, 600, and 800 mg/kg (GA400, GA600, and GA800) guanidinoacetic acid, respectively...
2024: Frontiers in Veterinary Science
#26
JOURNAL ARTICLE
Xuesong Fan, Xianjun Wang, Hongmei Zhao, Daqian Xiong, Min Hu, Lixin Wang, Aiping Pan, Carlo Gabelli, Matthew J Budoff, Hui Yuan
BACKGROUND: The reference intervals (RIs) of adult blood lipid parameters currently used in China are not derived from the results of research in local populations and have not been adjusted for age and sex. In this study, we aimed to determine accurate RIs for blood lipid parameters and blood glucose (GluG) for Chinese adults using a national multicenter study. METHODS: A total of 11,333 adults between 18 and 90 years of age were recruited in seven representative regions in China between June 2020 and December 2020...
February 15, 2024: Cardiovascular Diagnosis and Therapy
#27
JOURNAL ARTICLE
Min Cui, Hao Wu, Hanmo Zhang, Liping Wei, Xin Qi
BACKGROUND: Whether iron intake can affect cardiovascular disease (CVD) and dyslipidemia is controversial. However, few studies have focused on reducing the risk of CVD in people at risk for dyslipidemia. This study explored the linear relationship and possible nonlinear relationship between CVD and dyslipidemia. METHODS: Dietary data were obtained from the China Health and Nutrition Survey between 2004 and 2015. The survey included 8173 participants older than 18 years...
March 2, 2024: Lipids in Health and Disease
#28
REVIEW
Christopher J Costa, Minh Thu T Nguyen, Haleh Vaziri, George Y Wu
Gallstone (GS) disease is common and arises from a combination of genetic and environmental factors. Although genetic abnormalities specifically leading to cholesterol GSs are rare, there are clinically significant gene variants associated with cholesterol GSs. In contrast, most bilirubin GSs can be attributed to genetic defects. The pathogenesis of cholesterol and bilirubin GSs differs greatly. Cholesterol GSs are notably influenced by genetic variants within the ABC protein superfamily, including ABCG8, ABCG5, ABCB4, and ABCB11, as well as genes from the apolipoprotein family such as ApoB100 and ApoE (especially the E3/E3 and E3/E4 variants), and members of the MUC family...
March 28, 2024: Journal of Clinical and Translational Hepatology
#29
JOURNAL ARTICLE
Jiarong Zhang, Xinru Song, Zhi Li, Haibo Xu, Haotian Shu, Jun Li, Yan Zhang
AIMS: Research has shown that apolipoproteins (Apos) are potential indicators of heart health and death. We investigated the associations of apolipoprotein levels with all-cause and cardiovascular mortality. METHODS: We systematically searched the Cochrane Library, PubMed and Web of Science for English-language studies up to November 28, 2022. We used Stata 17.0 to summarize the estimated effects with 95% confidence intervals (CIs). We also conducted subgroup analyses according to study location, year of publication, individual age, follow-up years, and sample size...
February 28, 2024: European Journal of Preventive Cardiology
#30
JOURNAL ARTICLE
Miguel A Frias, Sabrina Pagano, Nasim Bararpour, Jonathan Sidibé, Festus Kamau, Vanessa Fétaud-Lapierre, Peter Hudson, Aurélien Thomas, Sandrine Lecour, Hans Strijdom, Nicolas Vuilleumier
OBJECTIVE: This study aimed to study the relationship between auto-antibodies against apolipoprotein A1 (anti-apoA1 IgG), human immunodeficiency virus (HIV) infection, anti-retroviral therapy (ART), and the tryptophan pathways in HIV-related cardiovascular disease. DESIGN: This case-control study conducted in South Africa consisted of control volunteers ( n = 50), people living with HIV (PLWH) on ART ( n = 50), and untreated PLWH ( n = 44)...
2024: Frontiers in Cardiovascular Medicine
#31
REVIEW
Peng Wang, Xue Lian Liu, Zong Zhe Jiang, Yang Long, Chen Lin Gao, Wei Huang, Xiao Zhen Tan, Xiu Mei Ma, Yong Xu
Proanthocyanidins (PCs) are natural antioxidant polyphenols and their effect on the regulation of blood lipids is still controversial. This study was conducted to evaluate the effect of PCs on lipid metabolism. We searched PubMed, Embase, Web of Science, Chinese biomedical literature service system, China National Knowledge Internet, and Wanfang Data with no time restriction until March 18, 2022, using various forms of "proanthocyanidins" and "blood lipid" search terms. Randomized controlled trials investigating the relationship between PCs and lipid metabolism were included...
February 23, 2024: Phytotherapy Research: PTR
#32
JOURNAL ARTICLE
Charalampos I Liakos, Leonidas Lanaras, Magdalini Bristianou, Dimitrios P Papadopoulos
The ideal approach to the secondary dyslipidemia goal of lowering triglycerides (TG) is not well established. The available ω-3 fatty acid products differ from each other in composition and content. The purpose of the present study was to investigate the effect of a highly purified eicosapentaenoic acid (EPA) formulation on cardiometabolic biomarkers in high cardiovascular (CV) risk patients. The study included 226 subjects with high TG and ≥1 of the following CV risk factors: arterial hypertension, diabetes mellitus, ultrasound-documented atheromatosis, peripheral artery disease, previous myocardial infarction, or ischemic stroke...
February 21, 2024: Lipids
#33
JOURNAL ARTICLE
Yueh-Chien Lin, Steven Swendeman, Irina S Moreira, Avishek Ghosh, Andrew Kuo, Nícia Rosário-Ferreira, Shihui Guo, Alan Culbertson, Michel V Levesque, Andreane Cartier, Takahiro Seno, Alec Schmaier, Sylvain Galvani, Asuka Inoue, Samir M Parikh, Garret A FitzGerald, David Zurakowski, Maofu Liao, Robert Flaumenhaft, Zeynep H Gümüş, Timothy Hla
High-density lipoprotein (HDL) nanoparticles promote endothelial cell (EC) function and suppress inflammation, but their utility in treating EC dysfunction has not been fully explored. Here, we describe a fusion protein named ApoA1-ApoM (A1M) consisting of apolipoprotein A1 (ApoA1), the principal structural protein of HDL that forms lipid nanoparticles, and ApoM, a chaperone for the bioactive lipid sphingosine 1-phosphate (S1P). A1M forms HDL-like particles, binds to S1P, and is signaling competent. Molecular dynamics simulations showed that the S1P-bound ApoM moiety in A1M efficiently activated EC surface receptors...
February 20, 2024: Science Signaling
#34
JOURNAL ARTICLE
Ioanna Skampardoni, Ilya M Nasrallah, Ahmed Abdulkadir, Junhao Wen, Randa Melhem, Elizabeth Mamourian, Guray Erus, Jimit Doshi, Ashish Singh, Zhijian Yang, Yuhan Cui, Gyujoon Hwang, Zheng Ren, Raymond Pomponio, Dhivya Srinivasan, Sindhuja Tirumalai Govindarajan, Paraskevi Parmpi, Katharina Wittfeld, Hans J Grabe, Robin Bülow, Stefan Frenzel, Duygu Tosun, Murat Bilgel, Yang An, Daniel S Marcus, Pamela LaMontagne, Susan R Heckbert, Thomas R Austin, Lenore J Launer, Aristeidis Sotiras, Mark A Espeland, Colin L Masters, Paul Maruff, Jurgen Fripp, Sterling C Johnson, John C Morris, Marilyn S Albert, R Nick Bryan, Kristine Yaffe, Henry Völzke, Luigi Ferrucci, Tammie L S Benzinger, Ali Ezzati, Russell T Shinohara, Yong Fan, Susan M Resnick, Mohamad Habes, David Wolk, Haochang Shou, Konstantina Nikita, Christos Davatzikos
IMPORTANCE: Brain aging elicits complex neuroanatomical changes influenced by multiple age-related pathologies. Understanding the heterogeneity of structural brain changes in aging may provide insights into preclinical stages of neurodegenerative diseases. OBJECTIVE: To derive subgroups with common patterns of variation in participants without diagnosed cognitive impairment (WODCI) in a data-driven manner and relate them to genetics, biomedical measures, and cognitive decline trajectories...
February 14, 2024: JAMA Psychiatry
#35
REVIEW
Aditi Sharma, Chakshu Sharma, Lalit Sharma, Pranay Wal, Preeti Mishra, Nitin Sachdeva, Shivam Yadav, Celia Vargas De-La Cruz, Sandeep Arora, Vetriselvan Subramaniyan, Ravi Rawat, Tapan Behl, Mukesh Nandave
Mostly, cardiovascular diseases are blamed for casualties in rheumatoid arthritis (RA) patients. Customarily, dyslipidemia is probably the most prevalent underlying cause of untimely demise in people suffering from RA as it hastens the expansion of atherosclerosis. The engagement of inflammatory cytokines like tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6), etc., is crucial in the progression and proliferation of both RA and abnormal lipid parameters. Thus, lipid abnormalities should be monitored frequently in patients with both primary and advanced RA stages...
February 9, 2024: Canadian Journal of Physiology and Pharmacology
#36
RANDOMIZED CONTROLLED TRIAL
Mototsugu Nagao, Jun Sasaki, Kyoko Tanimura-Inagaki, Ichiro Sakuma, Hitoshi Sugihara, Shinichi Oikawa
BACKGROUND: SGLT2 inhibitors and DPP4 inhibitors have been suggested to affect lipid metabolism. However, there are few randomized controlled trials comparing the effects on the lipid metabolism between the two types of antidiabetic drugs. The SUCRE study (UMIN ID: 000018084) was designed to compare the effects of ipragliflozin and sitagliptin on serum lipid and apolipoprotein profiles and other clinical parameters. METHODS: This is a multicenter, open-label, randomized, controlled trial...
February 8, 2024: Cardiovascular Diabetology
#37
JOURNAL ARTICLE
Ruoyu Li, Huai Bai, Linbo Guan, Xinghui Liu, Ping Fan, Mi Zhou, Yujie Wu, Yufeng Wang, Zhengting Zhu, Guoyu Wang, Yonghong Wang, Dehua Li
OBJECTIVE: To investigate the －75 G/A single-nucleotide polymorphism in the promoter region of apolipoprotein A1 gene ( apoA 1) and its association with gestational diabetes mellitus (GDM) in pregnant women and to provide references for the exploration in the molecular genetic basis of GDM. METHODS: A total of 626 GDM patients and 1022 normal pregnant women, ie, the controls, were included in the study. The genotyping of apoA 1 －75 G/A polymorphism was performed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis...
January 20, 2024: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
#38
JOURNAL ARTICLE
Jhalok Ronjan Talukdar, Matthew Cooper, Lyuba Lyutvyn, Dena Zeraatkar, Rahim Ali, Rachel Berbrier, Sabrina Janes, Vanessa Ha, Pauline B Darling, Mike Xue, Alexandro Chu, Fariha Chowdhury, Hope E Harnack, Louise Huang, Mikail Malik, Jacqui Powless, Florence V Lavergne, Xuehong Zhang, Shelley Ehrlich, David Ja Jenkins, John L Sievenpiper, Laura Banfield, Lawrence Mbuagbaw, Russell J de Souza
BACKGROUND: Inulin-type fructans (ITF) are the leading prebiotics in the market. Available evidence provides conflicting results regarding the beneficial effects of ITF on cardiovascular disease risk factors. OBJECTIVES: This study aimed to evaluate the effects of ITF supplementation on cardiovascular disease risk factors in adults. METHODS: We searched MEDLINE, EMBASE, Emcare, AMED, CINAHL, and the Cochrane Library databases from inception through May 15, 2022...
February 2024: American Journal of Clinical Nutrition
#39
JOURNAL ARTICLE
Xiang Gong, Chao Zheng, Ying Cai, Wen Zhang, Binyu Zhu, Rong Rong, Ying Kong, Yuan Zhang, Jian Wang, Yaping Li, Pengcheng Zhang
Adenosine (ADO) is a common chemotherapy-associated immune checkpoint that hinders anti-tumor immunity-mediated efficacy of chemotherapy. Herein, we created a synthetic high-density lipoprotein (sHDL) by co-assembly of a doxorubicin (DOX)-apolipoprotein A1 mimetic peptide conjugate, PSB-603 (an A2BR inhibitor), phospholipid, and cholesterol oleate with a microfluidic-based method. The obtained DP-sHDL showed a self-promoted drug delivery to cancer cells via remodeling tumor microenvironment. DP-sHDL could trigger the release of ATP from cancer cells and inhibit its conversion into ADO...
January 29, 2024: Journal of Controlled Release
#40
JOURNAL ARTICLE
Jiaqi Meng, Weichang Yang, Ziyong Chen, Caixia Pei, Xinmin Peng, Can Li, Fengyuan Li
PURPOSE: To investigate the value of apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), and ApoA1/B ratio in pathogenic diagnosis of chronic obstructive pulmonary disease (COPD) complicated by acute lower respiratory tract infection, assisting comprehensive disease assessment. PATIENTS AND METHODS: The study enrolled 171 COPD patients with acute lower respiratory tract infections, 35 COPD patients without acute lower respiratory tract infections, and 41 healthy controls...
2024: International Journal of Chronic Obstructive Pulmonary Disease
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