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Apolipoprotein A1

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https://www.readbyqxmd.com/read/29776362/apolipoprotein-b-apolipoprotein-a1-ratio-and-mortality-among-incident-peritoneal-dialysis-patients
#1
Xiaojiang Zhan, Yanbing Chen, Caixia Yan, Siyi Liu, Lijuan Deng, Yuting Yang, Panlin Qiu, Dan Pan, Bingxiang Zeng, Qinkai Chen
BACKGROUND: To investigate the association between the ratio of apolipoprotein B (apo B) / apolipoprotein A1 (apo A1) with all-cause mortality and cardiovascular events in peritoneal dialysis (PD) patients. METHODS: Eight hundred and sixty incident PD patients were enrolled from November 1, 2005, to February 28, 2017, and followed until May 31, 2017. Outcomes were all-cause mortality and cardiovascular events. Associations between the apo B/apo A1 ratio with all-cause mortality and cardiovascular events were evaluated using multivariable-adjusted Cox models...
May 17, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29772480/proteoglycan-4-regulates-macrophage-function-without-altering-atherosclerotic-lesion-formation-in-a-murine-bone-marrow-specific-deletion-model
#2
Joya E Nahon, Menno Hoekstra, Stefan R Havik, Peter J Van Santbrink, Geesje M Dallinga-Thie, Jan-Albert Kuivenhoven, Janine J Geerling, Miranda Van Eck
BACKGROUND AND AIMS: Proteoglycan 4 (Prg4) has a high structural similarity with the established atherosclerosis-modulating proteoglycan versican, but its role in atherogenesis is still unknown. Therefore, the impact of Prg4 deficiency on macrophage function in vitro and atherosclerosis susceptibility in vivo was investigated. METHODS: The presence and localization of Prg4 was studied in atherosclerotic lesions. Furthermore, the effect of Prg4 deficiency on macrophage foam cell formation, cholesterol efflux and lipopolysaccharide (LPS) response was determined...
May 5, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29764903/vitamin-d-supplementation-does-not-improve-cvd-risk-factors-in-vitamin-d-insufficient-subjects
#3
Julia Magdalena Kubiak, Per Medbøe Thorsby, Elena Kamycheva, Rolf Jorde
OBJECTIVE: Low serum 25(OH)D levels are associated with cardiovascular disease (CVD) and some of its risk factors. However, in interventional studies the effects of vitamin D supplementation have been uncertain, possibly due to inclusion of vitamin D sufficient subjects. Our aim was therefore to examine effects of vitamin D supplementation on CVD risk factors in vitamin D insufficient subjects. DESIGN: Double-blinded randomized controlled trial. METHODS: A four months interventional study with high dose vitamin D (100 000 IU loading dose, followed by 20 000 IU/week) or placebo with measurements of blood pressure, lipids (total-, LDL- and HDL-cholesterol, triglycerides, apolipoproteins A1 and B), and glucose metabolism parameters (blood glucose, HbA1c, sRAGE, insulin, C-peptide, and HOMA-IR)...
May 15, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29764762/analysis-of-plasma-albumin-vitamin-d-and-apolipoproteins-a-and-b-as-predictive-coronary-risk-biomarkers-in-the-regicor-study
#4
Gabriel Vázquez-Oliva, Alberto Zamora, Rafel Ramos, Isaac Subirana, María Grau, Irene R Dégano, Daniel Muñoz, Montserrat Fitó, Roberto Elosua, Jaume Marrugat
INTRODUCTION AND OBJECTIVES: New biomarkers could improve the predictive capacity of classic risk functions. The aims of this study were to determine the association between circulating levels of apolipoprotein A1 (apoA1), apolipoprotein B (apoB), albumin, and 25-OH-vitamin D and coronary events and to analyze whether these biomarkers improve the predictive capacity of the Framingham-REGICOR risk function. METHODS: A case-cohort study was designed. From an initial cohort of 5404 individuals aged 35 to 74 years with a 5-year follow-up, all the participants who had a coronary event (n = 117) and a random group of the cohort (subcohort; n = 667) were selected...
May 12, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29747660/association-of-the-apoa1-rs964184-snp-and-serum-lipid-traits-in-the-chinese-maonan-and-han-populations
#5
Ling Qiu, Rui-Xing Yin, Eksavang Khounphinith, Fen-Han Zhang, De-Zhai Yang, Shang-Ling Pan
BACKGROUND: Maonan nationality belongs to a mountain ethnic minority in China. Little is known about the association of apolipoprotein A1 gene (APOA1) rs964184 single nucleotide polymorphism (SNP) and serum lipid levels in this population. The aim of this study was to detect the association of the APOA1 rs964184 SNP and several environmental factors with serum lipid profiles in the Chinese Maonan and Han populations. METHODS: Genotypes of the APOA1 rs964184 SNP in 867 individuals of Maonan nationality and 820 participants of Han nationality were determined by polymerase chain reaction and restriction fragment length polymorphism, combined with gel electrophoresis, and confirmed by direct sequencing...
May 10, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29740584/associations-between-dietary-antioxidant-intake-and-markers-of-atherosclerosis-in-middle-aged-women-from-north-western-algeria
#6
Mustapha Diaf, Meghit Boumediene Khaled
Background: The role of several dietary antioxidants in preventing the development and the progression of atherosclerosis has recently aroused considerable interest. Although they are not yet conclusive, most of the existing suggestions support this hypothesis. Objective: The aim of the present work was to investigate the intake of dietary antioxidant nutrients in relation to atherogenic indices in a group of Algerian middle aged women with and without type 2 diabetes. Methods: A cross-sectional study was conducted on a group of middle-aged women from the north western region of Algeria...
2018: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29738371/apoa-1-mimetic-peptide-elk-2a2k2e-decreases-inflammatory-factor-levels-via-the-abca1-jak2-stat3-ttp-axis-in-thp-1-derived-macrophages
#7
Jia-Lin Wang, Duo Gong, Xin-Yan Hu, Su Wu, Xi-Long Zheng, Jie Wu, Xiao-Er Tang, Da-Wei Zhang, Chao-Ke Tang
OBJECTIVE: The aim of this study was to determine whether the apolipoprotein A-1 (apoA-1) mimetic peptide ELK-2A2K2E regulates inflammatory cytokine expression via activating the ATP-binding cassette transporter A1 (ABCA1)-janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3)- tristetraprolin (TTP) signaling pathway in THP-1 macrophage-derived foam cells. METHODS AND RESULTS: The cells were treated with the apoA-1 mimetic peptide ELK-2A2K2E at different concentrations (0, 20, 40, 80 μg/ml) or incubated with ELK-2A2K2E (40 μg/ml) for different times (0, 6, 12, 24 h)...
May 3, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29731826/expression-and-influence-of-pentraxin-3-hbalc-and-apoa1-apob-in-serum-of-patients-with-acute-myocardial-infarction-combined-with-diabetes-mellitus-type-2
#8
Yanxia Zhu, Xiaofang Wang, Weihua Wang, Hongguang Wang, Fenglei Zhang
The present study investigated the clinical significance of changes in levels of hypersensitive plasma pentraxin-3 (PTX3), hemoglobin A1c (HbAlc) and apolipoprotein A-I (ApoA1)/apolipoprotein B (ApoB) on patients with acute myocardial infarction (AMI) and diabetes mellitus type 2 (T2DM). After admission, 100 patients diagnosed with AMI combined with T2DM were selected as Group A. According to the level of fasting blood glucose (FBG), they were then subdivided into Group A1 (n=44) with FBG ≥13.0 mmol/l and Group A2 (n=56) with FBG <13...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29713185/preoperative-apolipoprotein-b-apolipoprotein-a1-ratio-a-novel-prognostic-factor-for-gastric-cancer
#9
Ming-Zhe Ma, Shu-Qiang Yuan, Yong-Ming Chen, Zhi-Wei Zhou
Background: The correlations between lipid profile (lipid molecules and their derivative indexes) and clinical outcome have been widely testified in many carcinomas, but its prognostic value remains unknown in gastric cancer (GC). Our purpose in the study was to comprehensively evaluate the clinical significance of lipid profile in GC. Methods: We retrospectively collected clinical information of 1,201 GC patients who received surgery at Sun Yat-sen University Cancer Center from 2005 to 2010...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29712758/microrna-33-regulates-the-population-of-peripheral-inflammatory-ly6c-high-monocytes-through-dual-pathways
#10
Osamu Baba, Takahiro Horie, Tetsushi Nakao, Daihiko Hakuno, Yasuhiro Nakashima, Hitoo Nishi, Yasuhide Kuwabara, Masataka Nishiga, Tomohiro Nishino, Yuya Ide, Fumiko Nakazeki, Satoshi Koyama, Masahiro Kimura, Ritsuko Hanada, Masahiro Kawahara, Takeshi Kimura, Koh Ono
MicroRNA (miR)-33 targets ATP-binding cassette transporter A1 (ABCA1), and its deficiency increases serum HDL-cholesterol (HDL-C) and ameliorates atherosclerosis. Although we previously reported that miR-33 deficiency increased peripheral Ly6Chigh monocytes on ApoE-deficient background, the effect of miR-33 on monocyte population is not fully elucidated especially on wild-type (WT) background.We found that Ly6Chigh monocytes in miR-33-/- mice were decreased in peripheral blood and increased in bone marrow (BM)...
April 30, 2018: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29704538/in-vitro-oxidized-hdl-and-hdl-from-type-2-diabetes-patients-have-reduced-ability-to-efflux-oxysterols-from-thp-1-macrophages
#11
Yinan Chena, Maud Arnal-Levron, Françoise Hullin-Matsuda, Carole Knibbe, Philippe Moulin, Céline Luquain-Costaz, Isabelle Delton
Oxidized LDL (OxLDL) that are enriched in products of lipid peroxidation including oxysterols have been shown to induce cellular oxidative stress and cytotoxicity therefore accelerating atheroma plaque formation. Upon oxLDL exposure of THP-1 macrophages, intracellular oxidation of LDL derived-cholesterol as well as endogenous cholesterol was increased. The oxysterols intracellularly produced were efficiently exported to HDL whereas apolipoprotein A1 was inefficient. These findings prompted us to investigate the consequences of modification of HDL by oxidation and glycation as observed in type 2 diabetes with respect to oxysterol and cholesterol efflux...
April 26, 2018: Biochimie
https://www.readbyqxmd.com/read/29695434/regulation-of-apolipoprotein-e-trafficking-by-hepatitis-c-virus-induced-autophagy
#12
Ja Yeon Kim, Jing-Hsiung James Ou
Apolipoprotein E (ApoE) plays an important role in the maturation and infectivity of hepatitis C virus (HCV). By analyzing the subcellular localization of ApoE in Huh7 hepatoma cells that harbored an HCV subgenomic RNA replicon, we found that ApoE colocalized with autophagosomes. This colocalization was marginally detected in HCV-infected cells apparently due to the depletion of ApoE by HCV, as the treatment with bafilomycin A1 (BafA1), a vacuolar ATPase inhibitor that inhibits autophagic protein degradation, partially restored the ApoE level and enhanced its colocalization with autophagosomes in HCV-infected cells...
April 25, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29680706/elevated-igm-against-n%C3%AE%C2%B5-carboxyethyl-lysine-modified-apolipoprotein-a1-peptide-141-147-in-taiwanese-with-alzheimer-s-disease
#13
Ching-Yu Lin, Jau-Jiuan Sheu, I-Shih Tsai, Sen-Te Wang, Li-Yu Yang, I-Uen Hsu, Hui-Wen Chang, Horng-Mo Lee, Shu-Huei Kao, Ching-Kuo Lee, Chien-Ho Chen, Yung-Feng Lin
OBJECTIVE: Advanced glycation end products (AGEs) are involved in the pathogenesis of Alzheimer's disease (AD). Specific AGEs and related autoantibodies may be early AD markers. Apolipoprotein A1 (ApoA1) and its post-translational modifications (PTMs) are associated with neurodegeneration and thus selected to test the hypothesis. METHODS: Serum samples from totally 64 AD or health control (HC) Taiwanese were analyzed. ApoA1 was isolated from the serum and examined through LC-MS/MS and PTM analyses...
April 19, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29678178/status-of-lipid-and-lipoprotein-in-female-breast-cancer-patients-at-initial-diagnosis-and-during-chemotherapy
#14
Xin Li, Zi-Li Liu, Yu-Tuan Wu, He Wu, Wei Dai, Bilal Arshad, Zhou Xu, Hao Li, Kai-Nan Wu, Ling-Quan Kong
BACKGROUND: The lipid profile status among breast cancer patients at initial diagnosis and during chemotherapy remain controversial. The aim of this study is to study the status of lipid and lipoprotein in female breast cancer patients at initial diagnosis and during chemotherapy. METHODS: We conducted a retrospective cohort study of the status of the lipid and lipoprotein in 1054 primarily diagnosed breast cancer patients and 2483 normal controls with age stratification, from July 2015 to October 2016...
April 20, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29670126/temporary-sequestration-of-cholesterol-and-phosphatidylcholine-within-extracellular-domains-of-abca1-during-nascent-hdl-generation
#15
Masato Ishigami, Fumihiko Ogasawara, Kohjiro Nagao, Hidehiko Hashimoto, Yasuhisa Kimura, Noriyuki Kioka, Kazumitsu Ueda
The quality and quantity of high-density lipoprotein (HDL) in blood plasma are important for preventing coronary artery disease. ATP-binding cassette protein A1 (ABCA1) and apolipoprotein A-I (apoA-I) play essential roles in nascent HDL formation, but controversy persists regarding the mechanism by which nascent HDL is generated. In the "direct loading model", apoA-I acquires lipids directly from ABCA1 while it is bound to the transporter. By contrast, in the "indirect model", apoA-I acquires lipids from the specific membrane domains created by ABCA1...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29660271/denaturation-via-surfactants-changes-composition-of-protein-corona
#16
Julius Mueller, Johanna Simon, Philipp Rohne, Claudia Koch-Brandt, Volker Mailaender, Svenja Morsbach, Katharina Landfester
The use of nanocarriers as drug delivery vehicles brings them into contact with blood plasma proteins. Polymeric nanocarriers require some sort of surfactant to ensure colloidal stability. Formation of the protein corona is therefore not only determined by the intrinsic properties of the nanocarrier itself, but also by the accompanying surfactant. Although it is well known that surfactants have an impact on protein structure, only few studies were conducted on the specific effect of surfactants on the composition of protein corona of nanocarriers...
April 16, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29653287/detecting-the-functional-complexities-between-high-density-lipoprotein-mimetics
#17
Yoshitaka J Sei, Jungho Ahn, Taeyoung Kim, Eunjung Shin, Angel J Santiago-Lopez, Seung Soon Jang, Noo Li Jeon, Young C Jang, YongTae Kim
High-density lipoprotein (HDL) is a key regulator of lipid homeostasis through its native roles like reverse cholesterol transport. The reconstitution of this natural nanoparticle (NP) has become a nexus between nanomedicine and multi-disease therapies, for which a major portion of HDL functionality is attributed to its primary scaffolding protein, apolipoprotein A1 (apoA1). ApoA1-mimetic peptides were formulated as cost-effective alternatives to apoA1-based therapies; reverse-4F (r4F) is one such peptide used as part of a nanoparticle platform...
April 6, 2018: Biomaterials
https://www.readbyqxmd.com/read/29628368/sebelipase-alfa-improves-atherogenic-biomarkers-in-adults-and-children-with-lysosomal-acid-lipase-deficiency
#18
Don P Wilson, Mark Friedman, Sachin Marulkar, Tyler Hamby, Eric Bruckert
BACKGROUND: Measures of atherogenic cholesterol, with and without concomitant use of lipid-lowering medications (LLMs), are reported with up to 52 weeks of sebelipase alfa treatment in children and adults with lysosomal acid lipase deficiency (LAL-D) participating in the phase 3 Acid Lipase Replacement Investigating Safety and Efficacy study (NCT01757184). OBJECTIVE: To examine the effects of sebelipase alfa on levels of atherogenic biomarkers in the Acid Lipase Replacement Investigating Safety and Efficacy study...
March 9, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29626583/abnormalities-in-the-relationship-of-paraoxonase-1-with-hdl-and-apolipoprotein-a1-and-their-possible-connection-to-hdl-dysfunctionality-in-type-2-diabetes
#19
Alena Viktorinova, Ingrid Jurkovicova, Lubomira Fabryova, Sona Kinova, Michal Koren, Anna Stecova, Klara Svitekova
AIMS: Lipid parameters, lipid risk indexes and lipid-related oxidative stress markers (paraoxonase 1 [PON1] and lipid peroxides [LPO]) reflect the actual status of lipid metabolism in type 2 diabetes (T2DM). We hypothesized that relationships of high-density lipoprotein cholesterol (HDL-c) with PON1 and apolipoprotein A1 (ApoA1) and/or PON1 with ApoA1 under conditions of hyperglycaemia and oxidative stress might reveal HDL functionality. We investigated relationships between PON1, LPO, and lipid risk markers in T2DM subjects and compared them with those in healthy subjects...
April 4, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29618920/vitreous-levels-of-apolipoprotein-a1-and-retinol-binding-protein-4-in-human-rhegmatogenous-retinal-detachment-associated-with-choroidal-detachment
#20
Nannan Ding, Shasha Luo, Jinjin Yu, Ying Zhou, Zhifeng Wu
Purpose: This study aims to quantify the concentration of apolipoprotein A1 (APOA1) and retinol binding protein (RBP4) expressed in the vitreous humors of patients with rhegmatogenous retinal detachment associated with choroidal detachment (RRDCD), rhegmatogenous retinal detachment (RRD), and idiopathic epimacular membrane (IEM). This study also aims to investigate the potential role of APOA1 and RBP4 as biomarkers of RRDCD. Methods: Enzyme-linked immunosorbent assay (ELISA) kits were used to obtain levels of APOA1 and RBP4 from the vitreous humor samples of 76 primary patients...
2018: Molecular Vision
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