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Apolipoprotein A1

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https://www.readbyqxmd.com/read/28529180/structure-function-relationships-in-reconstituted-hdl-focus-on-antioxidative-activity-and-cholesterol-efflux-capacity
#1
Alexandre M O Cukier, Patrice Therond, Svetlana A Didichenko, Isabelle Guillas-Baudouin, M John Chapman, Samuel D Wright, Anatol Kontush
AIMS: High-density lipoprotein (HDL) contains multiple components that endow it with biological activities. Apolipoprotein A-I (apoA-I) and surface phospholipids contribute to these activities; however, structure-function relationships in HDL particles remain incompletely characterized. METHODS: Reconstituted HDLs (rHDLs) were prepared from apoA-I and soy phosphatidylcholine (PC) at molar ratios of 1:50, 1:100 and 1:150. Oxidative status of apoA-I was varied using controlled oxidation of Met112 residue...
May 18, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28511341/in-vivo-and-molecular-docking-studies-using-whole-extract-and-phytocompounds-of-aegle-marmelos-fruit-protective-effects-against-isoproterenol-induced-myocardial-infarction-in-rats
#2
Gadamsetty Saayi Krushna, Vutharadhi Leela Shivaranjani, Jolapuram Umamaheswari, Cheemanapalli Srinivasulu, Shaik Althaf Hussain, Mohammed Abdul Kareem, Vaddi Damodara Reddy, Daoud Ali, Kiran Bharat Lokhande, K Venkateswara Swamy, Lakshmi Devi Kodidhela
Myocardial infarction (MI) is a leading major health problem with increased morbidity and mortality worldwide. The present study investigates isoproterenol (ISO) induced MI and the beneficial role of Aegle marmelos fruit extract (AMFE) in rats. Our results indicated the significant augmentation of plasma nitric oxide (NOx) levels, C-reactive protein (CRP), homocysteine, apolipoprotein B (apo-B), cardiac tissue lipid peroxidation and liver 3-hydroxy-3 methyl glutaryl CoA (HMG-CoA) reductase activity in ISO treated rats (85mg/kg b...
May 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28502492/low-levels-of-apoa1-improve-risk-prediction-of-type-2-diabetes-mellitus
#3
Xing Wu, Zhexin Yu, Wen Su, Daniel A Isquith, Moni B Neradilek, Ning Lu, Fusheng Gu, Hongwei Li, Xue-Qiao Zhao
BACKGROUND: Type 2 diabetes mellitus (T2DM) has reported to be a major public health crisis in China. OBJECTIVE: We examined the incidence of new T2DM over 4 years for association of clinical factors and lipids with development of T2DM in a community-based population. METHODS: We included 923 Chinese subjects who participated in community-organized health checkout in both 2009 and 2013. Health history was collected; physical examination was performed; biochemistry, lipids, and glucose were measured...
March 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28500816/serum-lipids-and-lipoproteins-during-uncomplicated-malaria-a-cohort-study-in-lambar%C3%A3-n%C3%A3-gabon
#4
Benjamin J Visser, Sophia G de Vries, Rieke Vingerling, Martin Gritter, Danielle Kroon, Lídia Ciudad Aguilar, Rik B J Kraan, Rosanne W Wieten, François Danion, Barbara Sjouke, Akim A Adegnika, Selidji T Agnandji, Peter G Kremsner, Thomas Hänscheid, Petra F Mens, Michèle van Vugt, Martin P Grobusch
AbstractThe serum lipid profile in malaria patients has been found to differ from that of healthy controls. We investigated serum lipid profile changes in malaria patients over time compared with patients with other febrile diseases. In total, 217 patients were included in the study (111 malaria patients and 106 symptomatic controls, defined as malaria-negative febrile patients). Serum lipid levels (mmol/L) were significantly lower in malaria patients compared with those with other febrile diseases (total cholesterol [TC] = 3...
May 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28487312/complete-deletion-of-cd39-is-atheroprotective-in-apolipoprotein-e-deficient-mice
#5
Marco De Giorgi, Keiichi Enjyoji, Gordon Jiang, Eva Csizmadia, Shuji Mitsuhashi, Richard J Gumina, Ryszard T Smolenski, Simon C Robson
CD39 scavenges extracellular ATP and ADP, ultimately generating adenosine, a nucleoside, which has anti-inflammatory effects in the vasculature. We have evaluated the role of CD39 in the development of atherosclerosis in hyperlipidemic mice. ApoE KO (Cd39+/+/ApoE-/-) and Cd39/ApoE double knockout (Cd39-/-/ApoE-/-, DKO) mice were maintained on chow or Western diet for up to 20 weeks before evaluation of atherosclerotic lesions. We found that DKO mice exhibited significantly less atherosclerotic lesions than ApoE KO mice, irrespective of diet...
May 9, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28484991/lipid-testing-in-infectious-diseases-possible-role-in-diagnosis-and-prognosis
#6
REVIEW
Sebastian Filippas-Ntekouan, Evangelos Liberopoulos, Moses Elisaf
INTRODUCTION: Acute infections lead to significant alterations in metabolic regulation including lipids and lipoproteins, which play a central role in the host immune response. In this regard, several studies have investigated the role of lipid levels as a marker of infection severity and prognosis. SCOPE OF REVIEW: We review here the role of lipids in immune response and the potential mechanisms underneath. Moreover, we summarize studies on lipid and lipoprotein alterations in acute bacterial, viral and parasitic infections as well as their diagnostic and prognostic significance...
May 8, 2017: Infection
https://www.readbyqxmd.com/read/28475914/identification-of-potential-biomarkers-of-hepatotoxicity-by-plasma-proteome-analysis-of-arsenic-exposed-carp-labeo-rohita
#7
Sudeshna Banerjee, Arabinda Mahanty, Sasmita Mohanty, Debendranath Guha Mazumder, Phillip Cash, Bimal Prasanna Mohanty
Arsenic (As) is a toxic environmental contaminant and potential human carcinogen. Chronic intake of arsenic-contaminated water and food leads to arsenicosis, a major public health problem in many parts of the world. Early detection of arsenic toxicity would greatly benefit patients; however, the detection of arsenicosis needs to be done early before onset of severe symptoms in which case the tools used for detection have to be both sensitive and reliable. In this context, the present study investigated plasma proteome changes in arsenic-exposed Labeo rohita, with the aim of identifying biomarkers for arsenicosis...
April 24, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28462120/high-density-lipoprotein-cholesterol-hdl-c-in-cardiovascular-disease-effect-of-exercise-training
#8
REVIEW
Nayoung Ahn, Kijin Kim
Decreases in high-density lipoprotein cholesterol (HDL-C) levels are associated with an increased risk of coronary artery disease (CAD), whereas increased HDL-C levels are related to a decreased risk of CAD and myocardial infarction. Although HDL prevents the oxidation of low-density lipoprotein under normal conditions, it triggers a structural change, inhibiting antiarteriosclerotic and anti-inflammatory functions, under pathological conditions such as oxidative stress, inflammation, and diabetes. HDL can transform into various structures based on the quantitative reduction and deformation of apolipoprotein A1 and is the primary cause of increased levels of dysfunctional HDL, which can lead to an increased risk of CAD...
September 2016: Integr Med Res
https://www.readbyqxmd.com/read/28455345/bilirubin-decreases-macrophage-cholesterol-efflux-and-atp-binding-cassette-transporter-a1-protein-expression
#9
Dongdong Wang, Anela Tosevska, Elke H Heiß, Angela Ladurner, Christine Mölzer, Marlies Wallner, Andrew Bulmer, Karl-Heinz Wagner, Verena M Dirsch, Atanas G Atanasov
BACKGROUND: Mild but chronically elevated circulating unconjugated bilirubin is associated with reduced total and low-density lipoprotein cholesterol concentration, which is associated with reduced cardiovascular disease risk. We aimed to investigate whether unconjugated bilirubin influences macrophage cholesterol efflux, as a potential mechanism for the altered circulating lipoprotein concentrations observed in hyperbilirubinemic individuals. METHODS AND RESULTS: Cholesterol efflux from THP-1 macrophages was assessed using plasma obtained from normo- and hyperbilirubinemic (Gilbert syndrome) humans (n=60 per group) or (heterozygote/homozygote Gunn) rats (n=20 per group) as an acceptor...
April 28, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28452727/-the-influence-of-lifestyle-on-biomarkers-of-fibrosis-in-patients-with-stable-coronary-heart-disease-on-the-background-of-non-alcoholic-fatty-liver-disease
#10
N Virstyuk, I Vakalyuk
Purpose - to assess the impact of lifestyle on non-alcoholic fatty liver disease (NAFLD) activity by influencing the fibrotic processes and hepatic steatosis in patients with stable coronary heart disease (CHD). 105 patients with stable CHD, combined with NAFLD were observed: Group I - control group; Group II - basic group. In each group, patients with non-alcoholic steatosis (subgroup A) and non-alcoholic steatohepatitis (subgroup B) were isolated. General clinical examination, electrocardiography, coronary angiography, echocardiography, liver functional state, serum lipid profile, fasting glucose, markers of fibrosis were conducted to all patients...
February 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28452126/plasma-proteome-of-buffaloes
#11
Leticia Gomes de Pontes, Nayara Rodrigues Vieira Cavassan, Luciana Curtolo de Barros, Rui Seabra Ferreira Junior, Benedito Barraviera, Lucilene Delazari Dos Santos
The proteomic approach has aroused the interest of veterinary medicine researchers, especially regarding the production of biopharmaceuticals and diagnosis of diseases in farm animals. Water buffaloes have gained prominence in the world economy due to the quality of their milk, meat and leather, in addition to being an important donor of blood components. This work aimed to identify and characterize the proteins present in the blood plasma of Murrah buffaloes (Bubalus bubalis) through 2D-electrophoresis, in gel protein digestion followed by mass spectrometry technique and for albumin depletion, in solution protein digestion followed by shotgun analysis...
April 28, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28437814/assessment-of-early-cardiovascular-risk-in-children-and-adolescents-with-essential-hypertension
#12
Andreja Stelcar, Evgenija Homsak, Natasa Marcun Varda
The aim of our study was to investigate some early markers of hypertensive target organ damage in hypertensive children and adolescents, and to detect those showing most prominent clinical significance. We included 100 children with essential hypertension (EH) and 50 age-matched healthy control children, and evaluated left ventricular mass (LVM), intima-media thickness in the carotid arteries (IMT), pulse wave velocity (PWV), microalbuminuria, biochemical parameters and some adipokines. Statistically significant differences between the 2 groups were observed for HDL-cholesterol, LDL-cholesterol, triglycerides, insulin, uric acid, glucose, apolipoprotein A1, and total adiponectin...
April 24, 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/28434000/apolipoprotein-a1-inhibits-the-tgf-%C3%AE-1-induced-endothelial-to-mesenchymal-transition-of-human-coronary-artery-endothelial-cells
#13
Juling Feng, Jingjing Zhang, Ampadu O Jackson, Xiao Zhu, Hainan Chen, Wen Chen, Qingjun Gui, Kai Yin
OBJECTIVE: Transforming growth factor β1 (TGF-β1) is the major cytokine for stimulating endothelial cells (ECs) to transdifferentiate to mesenchymal cells (MCs) in the process known as endothelial-to-mesenchymal transition (EndMT). Recently, TGF-β1-induced EndMT has been implicated in the pathogenesis of atherosclerosis (AS). It has been identified that apolipoprotein A1 (ApoA-I) obstructs TGF-β1-induced endothelial dysfunction, providing a protective effect for ECs and also anti-AS activity...
April 22, 2017: Cardiology
https://www.readbyqxmd.com/read/28424539/%C3%AE-3-adrenoceptor-activation-upregulates-apolipoprotein-a-i-expression-in-hepg2-cells-which-might-further-promote-cholesterol-efflux-from-macrophage-foam-cells
#14
Xia-Qing Gao, Yan-Fang Li, Zhi-Li Jiang
OBJECTIVE: The aim of this study was to explore the effects of β3-adrenoceptor (β3-AR) activation on HepG2 cells and its influence on cholesterol efflux from macrophage foam cells. MATERIALS AND METHODS: HepG2 cells were cultured and treated with the β3-AR agonist, BRL37344, and antagonist, SR52390A, and the expression of apolipoprotein (Apo) A-I, ApoA-II, ApoB, and β3-AR in the supernatants and cells was determined. The expression of peroxisome proliferator-activated receptor (PPAR) γ and PPARα in the HepG2 cells was also assessed...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28424047/deciphering-mechanisms-underlying-the-genetic-variation-of-general-production-and-liver-quality-traits-in-the-overfed-mule-duck-by-pqtl-analyses
#15
Yoannah François, Alain Vignal, Caroline Molette, Nathalie Marty-Gasset, Stéphane Davail, Laurence Liaubet, Christel Marie-Etancelin
BACKGROUND: The aim of this study was to analyse the mechanisms that underlie phenotypic quantitative trait loci (QTL) in overfed mule ducks by identifying co-localized proteomic QTL (pQTL). The QTL design consisted of three families of common ducks that were progeny-tested by using 294 male mule ducks. This population of common ducks was genotyped using a genetic map that included 334 genetic markers located across 28 APL chromosomes (APL for Anas platyrhynchos). Mule ducks were phenotyped for 49 traits related to growth, metabolism, overfeeding ability and meat and fatty liver quality, and 326 soluble fatty liver proteins were quantified...
April 19, 2017: Genetics, Selection, Evolution: GSE
https://www.readbyqxmd.com/read/28416369/plasma-levels-of-apolipoprotein-a1-and-lecithin-cholesterol-acyltransferase-in-type-2-diabetes-mellitus-correlations-with-haptoglobin-phenotypes
#16
Samir Awadallah, Mohammed Madkour, Reem Al Hamidi, Esraa Abo Alwafa, Maram Hattab, Buhour Zakkour, Amna Al-Matroushi, Eslah Ahmed, Mariam Al-Kitbi
BACKGROUND: Previous studies have demonstrated that hemoglobin-haptoglobin (Hb-Hp) complex plays a role in developing vascular complications in type 2 diabetes mellitus (T2DM). The complexes bind with Apolipoprotein A1 (ApoA1) of high-density lipoprotein (HDL), affecting the function of Lecithin:Cholesterol Acyltransferase (LCAT), and impairing the reverse cholesterol transport mechanism (RCT). This study investigated the influence of Hp phenotypes on serum levels of ApoA1 and LCAT in patients with T2DM...
April 7, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28413474/obesity-contributes-more-to-increasing-apob-apoa1-ratio-than-hyperandrogenism-in-pcos-women-aged-20-38-years-in-china
#17
Jianhua Zheng, Qianqian Yin, Juanyi Cao, Bei Zhang
We investigated the association between the apolipoprotein B (ApoB)/apolipoprotein A1 (ApoA1) ratio and insulin resistance (IR), metabolic syndrome (MS) and its components in Chinese polycystic ovary syndrome (PCOS) adults. We also examined whether hyperandrogenism is involved in obesity-related metabolic abnormalities in a cohort of patients. A clinical cross-sectional study consisting of 532 Chinese PCOS adults aged 20-38 years was designed. Each subject underwent a physical examination and laboratory evaluation...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28407176/serum-proteomic-spectral-characteristics-of-acute-myeloid-leukemia-and-their-clinical-significance
#18
R-J Zheng, R-J Wu, X-D Ma
We investigated the differences between the serum proteomic spectral characteristics of acute myeloid leukemia (AML) patients and those of healthy people. We collected peripheral blood serum samples from 62 AML patients and 15 healthy controls. After removing high-abundance proteins, low-abundance serum proteins were separated using two-dimensional gel electrophoresis to identify differences between AML patients and healthy people. We investigated the different protein dots by mass fingerprint analysis, and evaluated the results using the Masort retrieval program provided by the MSDB protein bank...
April 13, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28391875/effects-of-mat9001-containing-eicosapentaenoic-acid-and-docosapentaenoic-acid-compared-to-eicosapentaenoic-acid-ethyl-esters-on-triglycerides-lipoprotein-cholesterol-and-related-variables
#19
Kevin C Maki, George Bobotas, Mary R Dicklin, Margie Huebner, William F Keane
BACKGROUND: Long-chain omega-3 fatty acid concentrate pharmaceuticals are used in the United States for treatment of severe hypertriglyceridemia (≥500 mg/dL) and are under investigation as adjuncts to statins for lowering cardiovascular risk in patients with high triglycerides (TGs; 200-499 mg/dL). OBJECTIVE: To evaluate MAT9001, an investigational prescription-only omega-3 fatty acid agent containing predominantly eicosapentaenoic acid (EPA) and docosapentaenoic acid, in 42 men and women with fasting TG 200 to 400 mg/dL...
January 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28384849/levels-of-apolipoprotein-a1-b100-and-lipoprotein-a-in-controlled-and-uncontrolled-diabetic-patients-and-in-non-diabetic-healthy-people
#20
Vishwal Indravadan Patel, Kinjal Prahaladbhai Patel, Mayur Goradhanbhai Makadia, Aashna Darshanbhai Shah, Kaushik Salubhai Chaudhari, Haridas Neelakandan Nilayangode
INTRODUCTION: Diabetes Mellitus (DM) is always a multifactorial metabolic disorder having a wide range of abnormalities in carbohydrate, lipid and protein metabolism. Dyslipidemia is a natural process of DM causing abnormal variations of different lipoproteins and it is one of the significant risk factors for Cardiovascular Disorder (CVD). There is a need to closely evaluate newer approaches in case of DM because even if dyslipidemia is treated, there is always a risk of CVDs in DM patients because of the hyperglycemia itself...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
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