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Apolipoprotein A1

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https://www.readbyqxmd.com/read/27909203/lipid-changes-around-the-final-menstrual-period-predict-carotid-subclinical-disease-in-postmenopausal-women
#1
Karen A Matthews, Samar R El Khoudary, Maria M Brooks, Carol A Derby, Siobán D Harlow, Emma J M Barinas-Mitchell, Rebecca C Thurston
BACKGROUND AND PURPOSE: Atherogenic changes in lipids occur among women around the time of the natural menopause, that is, within 1 year of the final menstrual period (FMP). We investigated whether lipid changes around the FMP are related to carotid intima-media thickness, interadventitial diameter, and plaque in postmenopausal women. METHODS: A total of 863 natural postmenopausal women with no history of heart attack or stroke underwent carotid ultrasound scans at follow-up year 12 or 13 of the Study of Women's Health Across the Nation...
December 1, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27891330/evaluation-of-lipid-profile-and-apolipoproteins-in-essential-hypertensive-patients
#2
Parsuram Nayak, Suchismita Panda, Pravat Kumar Thatoi, Roma Rattan, Srikrushna Mohapatra, Pramila Kumari Mishra
INTRODUCTION: Essential hypertension is one of the most common diseases of the Indian population contributing greatly to the morbidity, mortality and economic burden. It has a strong association with cardiovascular disease and abnormal lipid metabolism. Not only the traditional lipid parameters, but also the novel lipid components like Apo A1 and Apo B100 also have been identified to play a role. AIM: The present study was done to evaluate serum lipid profile and Apo A1, Apo B 100 in essential hypertensive patients and correlate their values with the degree of hypertension...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27890580/lipid-free-apoa-i-structure-origins-of-model-diversity
#3
REVIEW
Michael N Oda
Apolipoprotein A-I (apoA-I) is a prominent member of the exchangeable apolipoprotein class of proteins, capable of transitioning between lipid-bound and lipid-free states. It is the primary structural and functional protein of high density lipoprotein (HDL). Lipid-free apoA-I is critical to de novo HDL formation as it is the preferred substrate of the lipid transporter, ATP Binding Cassette Transporter A1 (ABCA1) Remaley et al. (2001) [1]. Lipid-free apoA-I is an important element in reverse cholesterol transport and comprehension of its structure is a core issue in our understanding of cholesterol metabolism...
November 24, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27887752/changes-in-plasma-fatty-acid-composition-are-associated-with-improvements-in-obesity-and-related-metabolic-disorders-a-therapeutic-approach-to-overweight-adolescents
#4
Marcela Guerendiain, Rosa Montes, Gemma López-Belmonte, Miguel Martín-Matillas, Ana I Castellote, Elena Martín-Bautista, Amelia Martí, J Alfredo Martínez, Luis Moreno, Jesús Mª Garagorri, Julia Wärnberg, Javier Caballero, Ascensión Marcos, M Carmen López-Sabater, Cristina Campoy
BACKGROUND & AIMS: In recent years, obesity has reached alarming levels among children and adolescents. The study of plasma fatty acid (FA) composition, as a reflection of diet, and its associations with other parameters, that are closely linked to obesity and the cardiometabolic profile, may be useful for setting nutritional goals for obesity treatment and prevention. This study explored the relationship between plasma FA levels and body fat and cardiometabolic risk markers, in overweight adolescents...
November 11, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27865270/serum-apolipoprotein-a1-as-a-possible-biomarker-for-monitoring-treatment-of-canine-leishmaniosis
#5
Damián Escribano, Asta Tvarijonaviciute, Meric Kocaturk, Jose Joaquín Cerón, Luis Pardo-Marín, Alejandro Torrecillas, Zeki Yilmaz, Silvia Martínez-Subiela
The aims of this study were: the identification of proteins differentially represented in the serum proteome of dogs with leishmaniosis after treatment and the verification of one selected protein as a possible biomarker for treatment monitoring. Serum samples from five dogs with leishmaniosis, before and after treatment were pooled into two groups and analysed using 2-dimensional electrophoresis followed by mass spectrometry analysis (MS). The MS analysis allowed the identification of 8 proteins differently expressed...
December 2016: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/27853278/integrative-mutation-haplotype-and-g%C3%A2-%C3%A3-%C3%A2-g-interaction-evidence-connects-abgl4-lrp8-and-pcsk9-genes-to-cardiometabolic-risk
#6
Tao Guo, Rui-Xing Yin, Li-Mei Yao, Feng Huang, Ling Pan, Wei-Xiong Lin, De-Zhai Yang, Shang-Ling Pan
This study is expected to investigate the association of ATP/GTP binding protein-like 4 (AGBL4), LDL receptor related protein 8 (LRP8) and proprotein convertase subtilisin/kexin type 9 (PCSK9) gene single nucleotide variants (SNVs) with lipid metabolism in 2,552 individuals (Jing, 1,272 and Han, 1,280). We identified 12 mutations in this motif. The genotype and allele frequencies of these variants were different between the two populations. Multiple-locus linkage disequilibrium (LD) elucidated the detected sites are not statistically independent...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27830342/refractory-ascites-in-systemic-lupus-erythematosus-further-biological-support-of-intraperitoneal-steroid-treatment-as-a-suitable-therapeutical-option
#7
Yemil Atisha-Fregoso, Diego F Hernández-Ramírez, Elizabeth Olivares-Martínez, Carlos A Núñez-Alvarez, Luis Llorente, Gabriela Hernández-Molina
The objective of this report was to evaluate the ascitic fluid of a patient with refractory lupus ascites (proband) at different time points-pre- and post-intraperitoneal treatment with dexamethasone-using a multiparametric approach which included the presence of autoantibodies and pro- and anti-inflammatory cytokines and chemokines, and a proteomic analysis. As controls, we studied two additional patients also with lupus ascites (only at basal evaluation) and two patients with ascites due to alcoholic liver cirrhosis...
November 9, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27824936/differential-effects-of-apoe4-and-activation-of-abca1-on-brain-and-plasma-lipoproteins
#8
Anat Boehm-Cagan, Roni Bar, Dror Harats, Aviv Shaish, Hana Levkovitz, John K Bielicki, Jan O Johansson, Daniel M Michaelson
Apolipoprotein E4 (apoE4), the leading genetic risk factor for Alzheimer's disease (AD), is less lipidated compared to the most common and AD-benign allele, apoE3. We have recently shown that i.p. injections of the ATP-binding cassette A1 (ABCA1) agonist peptide CS-6253 to apoE mice reverse the hypolipidation of apoE4 and the associated brain pathology and behavioral deficits. While in the brain apoE is the main cholesterol transporter, in the periphery apoE and apoA-I both serve as the major cholesterol transporters...
2016: PloS One
https://www.readbyqxmd.com/read/27793523/maternal-early-pregnancy-lipid-profile-and-offspring-s-lipids-and-glycaemic-control-at-age-5-6-years-the-abcd-study
#9
Noekie van Lieshout, Adriëtte J J M Oostvogels, Maaike G J Gademan, Tanja G M Vrijkotte
BACKGROUND & AIMS: Maternal early pregnancy lipid profile might influence offspring's lipids and glycaemic control, through an increased offspring's fat percentage. This explorative study investigates whether maternal early pregnancy lipid profile is associated with offspring's lipids and glycaemic control independently of offspring's fat percentage and if these associations are mediated by offspring's fat percentage. Possible sex differences in these associations are also examined. METHODS: 1133 mother-child pairs of the prospective ABCD-study were included...
October 15, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27792010/theobromine-induced-changes-in-a1-purinergic-receptor-gene-expression-and-distribution-in-a-rat-brain-alzheimer-s-disease-model
#10
Jesus Mendiola-Precoma, Karla Padilla, Alfredo Rodríguez-Cruz, Laura C Berumen, Ricardo Miledi, Guadalupe García-Alcocer
Dementia caused by Alzheimer's disease (AD) is mainly characterized by accumulation in the brain of extra- and intraneuronal amyloid-β (Aβ) and tau proteins, respectively, which selectively affect specific regions, particularly the neocortex and the hippocampus. Sporadic AD is mainly caused by an increase in apolipoprotein E, a component of chylomicrons, which are cholesterol transporters in the brain. Recent studies have shown that high lipid levels, especially cholesterol, are linked to AD. Adenosine is an atypical neurotransmitter that regulates a wide range of physiological functions by activating four P1 receptors (A1, A2A, A2B, and A3) and P2 purinergic receptors that are G protein-coupled...
October 24, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27790486/a-comparative-study-of-lipid-profile-and-cardiovascular-risk-biomarkers-among-chronic-haemodialysis-patients-and-healthy-individuals
#11
Shanmugam Lokesh, Tony Mathew Kadavanu, Siva Ranganathan Green, Tarun Kumar Dutta, Radhakrishnan Hemachandar, Arun Kumar Ramachandrappa, Shashank Rakesh Tiwari, Ezhumalai Govindasamy
INTRODUCTION: Lipid abnormalities and increase in inflammatory markers are common among patients with End Stage Renal Disease (ESRD) and it tends to persist/worsen even after initiating Intermittent Haemodialysis (IHD). The cardiovascular mortality and morbidity remains significantly high in this population. AIM: The present study was carried out to assess the pattern of lipid abnormality in our population and to find its association with inflammatory markers. MATERIALS AND METHODS: It was a cross-sectional, observational study on ESRD patients undergoing Haemodialysis (HD) in comparison with age and sex matched healthy individuals in a tertiary care hospital...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27784780/exendin-4-ameliorates-lipotoxicity-induced-glomerular-endothelial-cell-injury-by-improving-abc-transporter-a1-mediated-cholesterol-efflux-in-diabetic-apoe-knockout-mice
#12
Qing-Hua Yin, Rui Zhang, Li Li, Yi-Ting Wang, Jing-Ping Liu, Jie Zhang, Lin Bai, Jing-Qiu Cheng, Ping Fu, Fang Liu
The ATP-binding cassette transporter A1 (ABCA1), which promotes cholesterol efflux from cells and inhibits inflammatory responses, is highly expressed in the kidney. Research has shown that exendin-4, a glucagon-like peptide-1 receptor (GLP-1R) agonist, promotes ABCA1 expression in multiple tissues and organs; however, the mechanisms underlying exendin-4 induction of ABCA1 expression in glomerular endothelial cells are not fully understood. In this study we investigated the effect of exendin-4 on ABCA1 in glomerular endothelial cells of diabetic kidney disease (DKD) and the possible mechanism...
October 26, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27765770/pim-1l-protects-cell-surface-resident-abca1-from-lysosomal-degradation-in-hepatocytes-and-thereby-regulates-plasma-high-density-lipoprotein-level
#13
Akira Katsube, Hisamitsu Hayashi, Hiroyuki Kusuhara
OBJECTIVE: ATP-binding cassette transporter A1 (ABCA1) exerts an atheroprotective action through the biogenesis of high-density lipoprotein in hepatocytes and prevents the formation of foam cells from macrophages. Controlling ABCA1 is a rational approach to improving atherosclerotic cardiovascular disease. Although much is known about the regulatory mechanism of ABCA1 synthesis, the molecular mechanism underpinning its degradation remains to be clearly described. APPROACH AND RESULTS: ABCA1 possesses potential sites of phosphorylation by serine/threonine-protein kinase Pim-1 (Pim-1)...
October 20, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27758769/abca1-atp-binding-cassette-transporter-a1-mediates-apoa-i-apolipoprotein-a-i-and-apoa-i-mimetic-peptide-mobilization-of-extracellular-cholesterol-microdomains-deposited-by-macrophages
#14
Xueting Jin, Denis Sviridov, Ying Liu, Boris Vaisman, Lia Addadi, Alan T Remaley, Howard S Kruth
OBJECTIVE: We examined the function of ABCA1 (ATP-binding cassette transporter A1) in ApoA-I (apolipoprotein A-I) mobilization of cholesterol microdomains deposited into the extracellular matrix by cholesterol-enriched macrophages. We have also determined whether an ApoA-I mimetic peptide without and with complexing to sphingomyelin can mobilize macrophage-deposited cholesterol microdomains. APPROACH AND RESULTS: Extracellular cholesterol microdomains deposited by cholesterol-enriched macrophages were detected with a monoclonal antibody, 58B1...
December 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27713681/mass-spectrometry-based-approaches-to-targeted-quantitative-proteomics-in-cardiovascular-disease
#15
Clementina Mesaros, Ian A Blair
Mass spectrometry-based proteomics methodology has become an important tool in elucidating some of the underlying mechanisms involved in cardiovascular disease. The present review provides details on selected important protein targets where highly selective and specific mass spectrometry-based approaches have led to important new findings and provided new mechanistic information. The role of six proteins involved in the etiology of cardiovascular disease (acetylated platelet cyclooxygenase-1, serum apolipoprotein A1, apolipoprotein C-III, serum C-reactive protein, serum high mobility group box-1 protein, insulin-like growth factor I) and their quantification has been discussed...
2016: Clinical Proteomics
https://www.readbyqxmd.com/read/27702801/cholesterol-homeostasis-restoration-by-lxr-agonists-as-a-treatment-for-blastic-plasmacytoid-dendritic-cell-neoplasm
#16
Adam Ceroi, David Masson, Anne Roggy, Christophe Roumier, Cécile Chagué, Thierry Gauthier, Laure Philippe, Baptiste Lamarthée, Fanny Angelot-Delettre, Francis Bonnefoy, Sylvain Perruche, Sabeha Biichle, Claude Preudhomme, Elisabeth Macintyre, Laurent Lagrost, Francine Garnache-Ottou, Philippe Saas
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive hematological malignancy with a poor prognosis that derives from plasmacytoid dendritic cells (PDC). No consensus for optimal treatment modalities is available today and the full characterization of this leukemia is still emerging. We identified here a BPDCN-specific transcriptomic profile when compared to those of acute myeloid leukemia and T-acute lymphoblastic leukemia, as well as the transcriptomic signature of primary PDC. This BPDCN gene signature identified a dysregulation of genes involved in cholesterol homeostasis, some of them being liver X receptor (LXR) target genes...
October 4, 2016: Blood
https://www.readbyqxmd.com/read/27698729/triptolide-inhibits-the-progression-of-atherosclerosis-in-apolipoprotein-e-mice
#17
Longfeng Luo, Tianlun Yang
Atherosclerosis, the major cause of cardiovascular disease, is accompanied by a chronic inflammatory response during the disease. Triptolide (TPL) is an active natural compound that has been demonstrated to possess anti-inflammatory activities in various cell types. However, the effects of TPL on atherosclerosis have not yet been studied. The goal of the present study was to determine the effects of TPL on apolipoprotein E knock-out (ApoE(-)/(-)) mice fed with a high-fat diet and to analyze the changes in lipid metabolism and inflammatory cytokines to clarify the underlying molecular mechanisms...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27698541/effects-of-isoflavones-on-lipid-and-apolipoprotein-levels-in-patients-with-type-2-diabetes-in-heilongjiang-province-in-china
#18
Xiao-Xing Chi, Tao Zhang, Dong-Jie Zhang, Wei Yu, Qiu-Ying Wang, Jing-Long Zhen
In this study, we examined the association between soy isoflavones and lipid profiles, apolipoprotein levels in patients with type 2 diabetes in China. The study population was composed of 120 cases (80 women with type 2 diabetes and 40 healthy women). Objects in treatment group received isoflavones 435 mg/day for 2 months, then lipid profiles were analyzed by the colorimetry method and apolipoprotein levels were determined by immune turbidimetric method. And all the indexes were determined after oral glucose tolerance test...
September 2016: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/27683106/apolipoprotein-a1-a-novel-serum-biomarker-for-predicting-the-prognosis-of-hepatocellular-carcinoma-after-curative-resection
#19
Xiao-Lu Ma, Xing-Hui Gao, Zi-Jun Gong, Jiong Wu, Lu Tian, Chun-Yan Zhang, Yan Zhou, Yun-Fan Sun, Bo Hu, Shuang-Jian Qiu, Jian Zhou, Jia Fan, Wei Guo, Xin-Rong Yang
As a major protein constituent of high density lipoprotein, Apolipoprotein A1 (ApoA-1) might be associated with cancer progression. Our study investigated the serum ApoA-1 level for the prognosis of 443 patients with hepatocellular carcinoma (HCC) and its effects on tumor cells. We found that the serum ApoA-1 level was significantly lower in HCC patients with tumor recurrence, and was an independent indicator of tumor-free survival and overall survival. Low serum ApoA-1 levels were significantly associated with multiple tumors and high Barcelona Clinic Liver Cancer stage...
September 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27677368/corn-oil-intake-favorably-impacts-lipoprotein-cholesterol-apolipoprotein-and-lipoprotein-particle-levels-compared-with-extra-virgin-olive-oil
#20
K C Maki, A L Lawless, K M Kelley, V N Kaden, C J Geiger, O M Palacios, M R Dicklin
BACKGROUND: Corn oil (CO) and extra-virgin olive oil (EVOO) are rich sources of unsaturated fatty acids (UFA), but UFA profiles differ among oils, which may affect lipoprotein levels. OBJECTIVES: The objective of this study was to assess the effects of CO versus EVOO intake on fasting lipoprotein and subfraction cholesterol levels, apolipoprotein (apo) A1, apo B, and low-density lipoprotein particle concentrations in men and women. SUBJECTS/METHODS: As part of a weight maintenance diet, men and women were provided with food items prepared with 54 g per day of CO or EVOO (21-day treatment, 21-day washout) in a randomized, double-blind, controlled-feeding, crossover trial...
September 28, 2016: European Journal of Clinical Nutrition
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