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Apolipoprotein A1

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https://www.readbyqxmd.com/read/28337704/analysis-of-traditional-and-emerging-risk-factors-in-premenopausal-women-with-coronary-artery-disease-a-pilot-scale-study-from-north-india
#1
Rajesh Vijayvergiya, Divya Kapoor, Ajay Aggarwal, Sonal Sangwan, Vanita Suri, Veena Dhawan
Premenopausal women are known to have less heart disease than their menopausal counterparts and men. However, there is a rising prevalence of coronary artery disease (CAD) in premenopausal females, which necessitates determination of risk factors that negate the effects of hormonal protection. There are few studies describing the prevalence of traditional and emerging risk factors in premenopausal women with CAD. Thus, our objective was to explore the prevalence of traditional and emerging risk factors and features of coronary lesions in premenopausal women with CAD in an Indian population...
March 23, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28331418/optimization-of-pcr-condition-the-first-study-of-high-resolution-melting-technique-for-screening-of-apoa1-variance
#2
Hesty Wahyuningsih, Ferdy K Cayami, Udin Bahrudin, Mochamad A Sobirin, Farmaditya Ep Mundhofir, Sultana Mh Faradz, Ichiro Hisatome
BACKGROUND: High resolution melting (HRM) is a post-PCR technique for variant screening and genotyping based on the different melting points of DNA fragments. The advantages of this technique are that it is fast, simple, and efficient and has a high output, particularly for screening of a large number of samples. APOA1 encodes apolipoprotein A1 (apoA1) which is a major component of high density lipoprotein cholesterol (HDL-C). This study aimed to obtain an optimal quantitative polymerase chain reaction (qPCR)-HRM condition for screening of APOA1 variance...
March 2017: Yonago Acta Medica
https://www.readbyqxmd.com/read/28330813/atp-binding-cassette-transporter-a1-deficiency-in-human-induced-pluripotent-stem-cell-derived-hepatocytes-abrogates-hdl-biogenesis-and-enhances-triglyceride-secretion
#3
Xin Bi, Evanthia E Pashos, Marina Cuchel, Nicholas N Lyssenko, Mayda Hernandez, Antonino Picataggi, James McParland, Wenli Yang, Ying Liu, Ruilan Yan, Christopher Yu, Stephanie L DerOhannessian, Michael C Phillips, Edward E Morrisey, Stephen A Duncan, Daniel J Rader
Despite the recognized role of the ATP-binding Cassette Transporter A1 (ABCA1) in high-density lipoprotein (HDL) metabolism, our understanding of ABCA1 deficiency in human hepatocytes is limited. To define the functional effects of human hepatocyte ABCA1 deficiency, we generated induced pluripotent stem cell (iPSC)-derived hepatocyte-like cells (HLCs) from Tangier disease (TD) and matched control subjects. Control HLCs exhibited robust cholesterol efflux to apolipoprotein A-I (apoA-I) and formed nascent HDL particles...
March 14, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28317819/-correlation-of-chronic-periodontal-disease-and-cardiovascular-disease
#4
A I Grudyanov, O N Tkacheva, T V Avraamova
The aim of the study was to assess correlative risk of progression of inflammatory periodontal lesions, the development of a systemic inflammatory reaction and cardiovascular diseases. The study involved 89 patients with chronic periodontal disease (CPD) of varying degrees. High cardiovascular disease risk was revealed in 8.8% of patients with moderate and 13.3% of patients with severe periodontal disease. It is proved that an additional factor contributing to the pathogenic relationship between periodontal inflammatory changes and the development of cardiovascular disease is systemic inflammatory response with increased hrC-reactive protein >3...
2017: Stomatologii︠a︡
https://www.readbyqxmd.com/read/28304324/assessment-of-serum-apolipoprotien-b-and-apolipoprotein-a-1-and-their-ratio-in-healthy-full-term-small-for-gestational-age-newborns
#5
A Agrawal, J Shrivastava, R Dwivedi, M Siddiqui
BACKGROUND: Programmed changes in growth restricted fetuses can increase the risk of adulthood diseases due to elevated serum cholesterol and apolipoprotein-B (Apo-B) concentrations. Increasing evidence demonstrated the role of apoB/apoA-I ratio as a strong risk factor for cardiovascular diseases. OBJECTIVE: To determine the concentration of cord blood lipoproteins and apolipoproteins as well as their correlation with birth weight. METHODS: This cross-sectional study was conducted in a teaching institution of central India...
March 16, 2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28274624/the-apolipoprotein-a-i-mimetic-peptide-d-4f-alleviates-ox-ldl-induced-oxidative-stress-and-promotes-endothelial-repair-through-the-enos-ho-1-pathway
#6
Donghui Liu, Zhenzhen Ding, Mengzhang Wu, Wenqi Xu, Mingming Qian, Qian Du, Le Zhang, Ye Cui, Jianlan Zheng, He Chang, Caihua Huang, Donghai Lin, Yan Wang
Apolipoprotein A-I (apoA-I) mimetic peptide exerts many anti-atherogenic properties. However, the underlying mechanisms related to the endothelial protective effects remain elusive. In this study, the apoA-I mimetic peptide, D-4F, was used. Proliferation assay, wound healing, and transwell migration experiments showed that D-4F improved the impaired endothelial proliferation and migration resulting from ox-LDL. Endothelial adhesion molecules expression and monocyte adhesion assay demonstrated that D-4F inhibited endothelial inflammation...
March 6, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28274171/differential-representation-of-liver-proteins-in-obese-human-subjects-suggests-novel-biomarkers-and-promising-targets-for-drug-development-in-obesity
#7
Simonetta Caira, Antonio Iannelli, Rosaria Sciarrillo, Gianluca Picariello, Giovanni Renzone, Andrea Scaloni, Pietro Addeo
The proteome of liver biopsies from human obese (O) subjects has been compared to those of nonobese (NO) subjects using two-dimensional gel electrophoresis (2-DE). Differentially represented proteins were identified by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS)-based peptide mass fingerprinting (PMF) and nanoflow-liquid chromatography coupled to electrospray-tandem mass spectrometry (nLC-ESI-MS/MS). Overall, 61 gene products common to all of the liver biopsies were identified within 65 spots, among which 25 ones were differently represented between O and NO subjects...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28264492/lifestyle-and-dietary-determinants-of-serum-apolipoprotein-a1-and-apolipoprotein-b-concentrations-cross-sectional-analyses-within-a-swedish-cohort-of-24-984-individuals
#8
Kasper Frondelius, Madelene Borg, Ulrika Ericson, Yan Borné, Olle Melander, Emily Sonestedt
Low serum apolipoprotein (Apo) A1 concentrations and high serum ApoB concentrations may be better markers of the risk of cardiovascular disease than high-density lipoprotein (HDL) and low-density lipoprotein (LDL). However, the associations between modifiable lifestyle factors and Apo concentrations have not been investigated in detail. Therefore, this study investigated the associations between Apo concentrations and education, lifestyle factors and dietary intake (macronutrients and 34 food groups). These cross-sectional associations were examined among 24,984 individuals in a Swedish population-based cohort...
February 28, 2017: Nutrients
https://www.readbyqxmd.com/read/28262755/clinical-characteristics-and-prognosis-of-cerebral-venous-thrombosis-in-chinese-women-during-pregnancy-and-puerperium
#9
Zhu-Wei Liang, Wan-Li Gao, Li-Min Feng
Due to the specific physiology associated with pregnancy and puerperium, cerebral venous sinus thrombosis (CVT) may manifest different characteristics. This study aimed to identify the clinical manifestations and prognosis of pregnancy-associated CVT. A total of 43 pregnancy-associated CVT patients were enrolled. We analysed the clinical presentations of the disease and performed a multivariate logistic regression analysis to determine which variables were associated with prognosis. Our descriptive results showed the following: 1) the incidence was 202 per 100,000 deliveries, and the mortality rate was 11...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28253220/fat-mass-and-obesity-associated-protein-attenuates-lipid-accumulation-in-macrophage-foam-cells-and-alleviates-atherosclerosis-in-apolipoprotein-e-deficient-mice
#10
Chunfen Mo, Ming Yang, Xiaojuan Han, Junhong Li, Guangping Gao, Haoran Tai, Ning Huang, Hengyi Xiao
OBJECTIVE: Genome-wide association studies have linked variants of fat mass and obesity-associated protein (FTO) to obesity. However, the molecular function of FTO remains unclear. In this study, we sought to investigate the potential effects of FTO in modulating cholesterol deposition in macrophage foam cells, as well as whether FTO exerts antiatherosclerotic properties in apolipoprotein E-deficient mice. METHOD AND RESULTS: We transfected RAW264.7 cells with plasmids encoding a wild-type or mutant FTO gene (I367F)...
April 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28250989/apolipoprotein-c-i-levels-are-associated-with-the-urinary-protein-urinary-creatinine-ratio-in-pediatric-idiopathic-steroid-sensitive-nephrotic-syndrome-a-case-control-study
#11
Jun Odaka, Takahiro Kanai, Takane Ito, Takashi Saito, Jun Aoyagi, Hiroyuki Betsui, Takanori Yamagata
Humoral factors may cause idiopathic steroid-sensitive nephrotic syndrome (ISSNS). In the present study, we analyzed serum proteins using mass spectrometry (MS) to identify proteins associated with the pathophysiology of pediatric ISSNS. We collected serial serum samples from 33 children during each ISSNS phase; Phase A1 is the acute phase prior to steroid treatment (STx), Phase A2 represents the remission period with STx, and Phase A3 represents the remission period after completion of STx. Children with normal urinalyses (Group B) and children with a nephrotic syndrome other than ISSNS (Group C) served as controls...
2017: International Journal of Nephrology
https://www.readbyqxmd.com/read/28245873/effect-of-two-lipid-lowering-strategies-on-high-density-lipoprotein-function-and-some-hdl-related-proteins-a-randomized-clinical-trial
#12
Chan Joo Lee, Seungbum Choi, Dong Huey Cheon, Kyeong Yeon Kim, Eun Jeong Cheon, Soo-Jin Ann, Hye-Min Noh, Sungha Park, Seok-Min Kang, Donghoon Choi, Ji Eun Lee, Sang-Hak Lee
BACKGROUND: The influence of lipid-lowering therapy on high-density lipoprotein (HDL) is incompletely understood. We compared the effect of two lipid-lowering strategies on HDL functions and identified some HDL-related proteins. METHODS: Thirty two patients were initially screened and HDLs of 21 patients were finally analyzed. Patients were randomized to receive atorvastatin 20 mg (n = 11) or atorvastatin 5 mg/ezetimibe 10 mg combination (n = 10) for 8 weeks...
February 28, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28242047/simvastatin-treatment-aggravates-the-glucocorticoid-insufficiency-associated-with-hypocholesterolemia-in-mice
#13
Amber B Ouweneel, Ronald J van der Sluis, Joya E Nahon, Miranda Van Eck, Menno Hoekstra
BACKGROUND AND AIMS: Statin treatment disrupts HMG-CoA reductase-mediated endogenous cholesterol synthesis and lowers plasma LDL-cholesterol levels. Although statin treatment can theoretically impair adrenal steroid hormone synthesis, thus far, no effect on glucocorticoid output has been described, as LDL-cholesterol levels usually remain within the physiological range. However, novel statin-based treatment regimens that dramatically decrease LDL-cholesterol levels are currently employed...
February 20, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28241068/liver-x-receptor-agonist-treatment-significantly-affects-phenotype-and-transcriptome-of-apoe3-and-apoe4-abca1-haplo-deficient-mice
#14
Alexis Y Carter, Florent Letronne, Nicholas F Fitz, Anais Mounier, Cody M Wolfe, Kyong Nyon Nam, Valerie L Reeves, Hafsa Kamboh, Iliya Lefterov, Radosveta Koldamova
ATP-binding cassette transporter A1 (ABCA1) controls cholesterol and phospholipid efflux to lipid-poor apolipoprotein E (APOE) and is transcriptionally controlled by Liver X receptors (LXRs) and Retinoic X Receptors (RXRs). In APP transgenic mice, lack of Abca1 increased Aβ deposition and cognitive deficits. Abca1 haplo-deficiency in mice expressing human APOE isoforms, increased level of Aβ oligomers and worsened memory deficits, preferentially in APOE4 mice. In contrast upregulation of Abca1 by LXR/RXR agonists significantly ameliorated pathological phenotype of those mice...
2017: PloS One
https://www.readbyqxmd.com/read/28238629/apolipoprotein-a1-rs5070-a-g-polymorphism-with-stroke-subtypes-in-taiwan
#15
Li-Chi Hsu, Tsong-Hai Lee
BACKGROUND: Apolipoprotein A1 (ApoA1) is a structural protein of high-density lipoprotein cholesterol; ApoA1 is involved in lipid and cholesterol metabolism. This study evaluated the association of ApoA1 polymorphism (rs5070) with different stroke subtypes in Taiwanese individuals. METHODS: A total of 2139 cases, including 614 controls and 708 large artery atherosclerosis (LAA), 377 small-vessel occlusion, and 440 hypertensive intracranial hemorrhage cases, were enrolled in this study...
February 23, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28228355/altered-lipid-metabolism-in-rat-offspring-of-dams-fed-a-low-protein-diet-containing-soy-protein-isolate
#16
Mi Yoon, Sae Bom Won, Young Hye Kwon
AIMS: Substantial studies have reported that maternal protein restriction may induce later development of cardiovascular disease in offspring by impairing antioxidant system and lipid metabolism. Because a unique amino acid composition of soy protein isolate has shown to provide health benefits, including hypolipidemic effects, we investigated effects of maternal low-protein diet composed of low-isoflavone soy protein isolate (SPI) on oxidative stress and lipid metabolism in offspring...
February 20, 2017: Life Sciences
https://www.readbyqxmd.com/read/28228309/correlation-of-compliance-to-statin-therapy-with-lipid-profile-and-serum-hmgcoa-reductase-levels-in-dyslipidemic-patients
#17
Abhinav Grover, Harmeet Singh Rehan, Lalit Kumar Gupta, Madhur Yadav
BACKGROUND: The efficacy of statin therapy may be lost or vary with reduction in compliance and intensity of statin therapy. OBJECTIVE: To study and correlate the quantitative effect of compliance on lipid profile and 3-hydroxyl-3-methylglutaryl coenzyme A reductase (HMGCoA-R) levels in dyslipidemic patients. METHODS: Compliance to different intensity of statin therapy assessed by pill count was correlated with serum levels of total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), triglycerides (TG), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB) and HMGCoA-R...
January 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28219664/effect-of-pioglitazone-on-cardiometabolic-risk-in-patients-with-obstructive-sleep-apnea
#18
Alice Liu, Fahim Abbasi, Sun H Kim, Danit Ariel, Cindy Lamendola, James Cardell, Shiming Xu, Shailja Patel, Vanessa Tomasso, Hafasa Mojaddidi, Kaylene Grove, Philip S Tsao, Clete A Kushida, Gerald M Reaven
Prevalence of insulin resistance is increased in patients with obstructive sleep apnea (OSA). Because insulin resistance is an independent predictor of cardiovascular disease (CVD), this study was initiated to see if pioglitazone administration would improve insulin sensitivity and thereby decrease risk of CVD in overweight/obese, nondiabetic, insulin-resistant patients with untreated OSA. Patients (n = 30) were administered pioglitazone (45 mg/day) for 8 weeks, and measurements were made before and after intervention of insulin action (insulin-mediated glucose uptake by the insulin suppression test), C-reactive protein, lipid/lipoprotein profile, and gene expression profile of periumbilical subcutaneous fat tissue...
January 25, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28217507/stronger-relationship-of-serum-apolipoprotein-a-1-and-b-with-diabetic-retinopathy-than-traditional-lipids
#19
B S Ankit, G Mathur, R P Agrawal, K C Mathur
AIM: Diabetic retinopathy (DR) is the most common preventable cause of blindness where early detection and treatment can be sight-saving. Search for biomarkers of the disease has been relentless. We aimed to determine whether lipoproteins apolipoproteins A1 and B1 (Apo-A1 and Apo-B1) have stronger associations with DR in contrast to conventionally measured low-density lipoprotein (LDL) and high-density lipoprotein cholesterol levels. MATERIALS AND METHODS: We performed a cross-sectional study and studied 117 patients...
January 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28212898/low-serum-iron-is-associated-with-high-serum-intact-fgf23-in-elderly-men-the-swedish-mros-study
#20
Catharina Lewerin, Östen Ljunggren, Herman Nilsson-Ehle, Magnus K Karlsson, Hans Herlitz, Mattias Lorentzon, Claes Ohlsson, Dan Mellström
BACKGROUND: Fibroblast growth factor (FGF23) is a protein that is produced by osteoblasts and osteocytes. Increased serum levels of FGF23 have been associated with increased risks of osteoporotic fractures and cardiovascular disease, particularly in participants with poor renal function. Serum iron (Fe) has been suggested as a regulator of FGF23 homeostasis. OBJECTIVE: To determine whether Fe and iron status are determinants of the levels of intact FGF23 (iFGF23) in elderly men...
February 14, 2017: Bone
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