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https://www.readbyqxmd.com/read/28638079/transcriptome-changes-between-compatible-and-incompatible-graft-combination-of-litchi-chinensis-by-digital-gene-expression-profile
#1
Zhe Chen, Jietang Zhao, Fuchu Hu, Yonghua Qin, Xianghe Wang, Guibing Hu
Plant grafting has been practiced widely in horticulture and proved as a useful tool in science. However, the mechanisms of graft healing or graft incompatibility remain poorly understood. In this study, Litchi chinensis cv. 'Jingganghongnuo' homograft ('J/J') and 'Jingganghongnuo'/'zhuangyuanhong' heterograft ('J/Z') as compatible and incompatible combination, respectively, was used to study transcriptional changes between incompatible and compatible graft during graft union formation. Anatomical observation indicated that three stages (2 h, 14 d and 21 d after grafting) were critical for graft union formation and selected for high-throughput sequencing...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28625011/liver-epithelioid-progenitor-cells-derived-from-fetal-luxi-bovine-alleviate-liver-fibrosis
#2
Kunfu Wang, Hao Liu, Jinjuan Yang, Caiyun Ma, Zebiao Zhang, Dong Zheng, Weijun Guan
Liver epithelioid progenitor cells (LEPCs) have important roles in liver therapy because of their hepatic differentiation potency in vitro and in vivo. Despite many researches on humans, mice, and rats, equivalent progenitor cells derived from bovine are relatively rare. The purpose of our current study is to characterize bovine LEPCs, and research on the cure potency of this heteroplastic progenitor cells on mice liver fibrosis. We have used collagenase IV digesting and differential adhesion method to isolate slabstone shape, EpCAM, LGR5, NCAM1 and SOX9 positive progenitor cells from fetal Luxi bovine liver...
June 17, 2017: Cytotechnology
https://www.readbyqxmd.com/read/28584886/uv-responsive-amphiphilic-graft-copolymers-based-on-coumarin-and-polyoxazoline
#3
Laetitia Korchia, Vincent Lapinte, Christophe Travelet, Redouane Borsali, Jean-Jacques Robin, Cécile Bouilhac
A series of amphiphilic photo-responsive heterografted copolymers have been successfully synthesized. The random copolymers were composed of a methacrylate backbone, with various compositions of hydrophilic oligomeric 2-methyl-2-oxazoline side chains (OMOx) and hydrophobic long alkyl chains terminated by a coumarin moiety (Cm). Using dynamic (DLS) and static light scattering (SLS), and transmission electron microscopy (TEM), their self-assembling behavior was studied in water using the nanoprecipitation method...
June 6, 2017: Soft Matter
https://www.readbyqxmd.com/read/28320284/apoptotic-endonuclease-endog-inhibits-telomerase-activity-and-induces-malignant-transformation-of-human-cd4-t-cells
#4
D A Vasina, D D Zhdanov, E V Orlova, V S Orlova, M V Pokrovskaya, S S Aleksandrova, N N Sokolov
Telomerase activity is regulated by an alternative splicing of mRNA of the telomerase catalytic subunit hTERT (human telomerase reverse transcriptase). Increased expression of the inactive spliced hTERT results in inhibition of telomerase activity. Little is known about the mechanism of hTERT mRNA alternative splicing. This study was aimed at determining the effect of an apoptotic endonuclease G (EndoG) on alternative splicing of hTERT and telomerase activity in CD4+ human T lymphocytes. Overexpression of EndoG in CD4+ T cells downregulated the expression of the active full-length hTERT variant and upregulated the inactive alternatively spliced variant...
January 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/27956230/carotid-reconstruction-with-bovine-carotid-heterograft-after-en-bloc-resection-of-squamous-cell-carcinoma-with-direct-internal-carotid-invasion
#5
Eric B Trestman, Evan Garfein, Thomas Ow, Evan C Lipsitz, Pablo De Los Santos, Saadat Shariff
We report a novel use of Artegraft (North Brunswick, NJ) bovine heterograft for carotid reconstruction after resection of a neck squamous cell carcinoma (SCC). A 65-year-old man presented with a large left neck SCC encasing and invading the cervical internal carotid artery (ICA). Computed tomography angiography revealed an incomplete Circle of Willis, and no viable vein conduit on duplex mapping. The patient underwent en bloc resection including portion of the cervical ICA followed by reconstruction with Artegraft which was well tolerated...
December 9, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27888571/melody-valve-implantation-within-freestyle-stentless-porcine-aortic-heterograft
#6
James A Kuo, Ashlea A Feezel, Traci N Putnam, Deborah A Schutte
BACKGROUND: The Melody transcatheter pulmonary valve has been implanted successfully worldwide since its first implant in 2000. The vast majority of these valves have been implanted in pulmonary homografts. In our institution, the most common valve used for pulmonary valve replacement is the Medtronic Freestyle stentless porcine aortic heterograft. OBJECTIVE: We describe our experience implanting the Melody valve within the Freestyle heterograft. METHODS: Retrospective chart review was performed...
November 26, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27620913/nt-probnp-and-exercise-capacity-in-adult-patients-with-congenital-heart-disease-and-a%C3%A2-prosthetic-valve-a%C3%A2-multicentre-prostava-study
#7
R C Schoonbeek, P G Pieper, Y J van Slooten, H G Freling, G T Sieswerda, A P J van Dijk, M R M Jongbloed, M C Post, B J Bouma, R M F Berger, T Ebels, J P van Melle
OBJECTIVES: N-terminal B‑type natriuretic peptide (NT-proBNP) is an important biomarker for the detection of heart failure. Adults with congenital heart disease (ACHD) and a prosthetic heart valve are at risk for heart failure. This study aimed to determine the value of NT-proBNP in ACHD patients with a prosthetic valve and investigate its relationship with cardiac function and exercise capacity. METHODS: In this multi-centre cross-sectional observational study, data regarding medical history, echocardiography, exercise testing (VO2peak) and laboratory blood evaluation (including NT-proBNP) were collected in ACHD patients with a single prosthetic valve (either homografts, heterografts or mechanical valves)...
November 2016: Netherlands Heart Journal
https://www.readbyqxmd.com/read/27549749/congenital-bicuspid-pulmonary-valve-an-uncommon-impede-for-ross-procedure
#8
Stéphane Kajingu Enciso, Maxime Elens, Jean Rubay
We report a case of successful heterograft aortic valve replacement following an impede Ross procedure in a 48-year-old man presenting with a congenital bicuspid pulmonary valve. The patient was admitted for aortic valve stenosis that required an aortic valve replacement (AVR). Owing to his young age and reluctance to long-term anticoagulation therapy, it was decided to do an AVR by pulmonary autograft. During surgery, the anatomical unsuitability of the graft was discovered leading to the procedure's readjustment...
April 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/27507280/biomechanical-behavior-of-bioprosthetic-heart-valve-heterograft-tissues-characterization-simulation-and-performance
#9
REVIEW
Joao S Soares, Kristen R Feaver, Will Zhang, David Kamensky, Ankush Aggarwal, Michael S Sacks
The use of replacement heart valves continues to grow due to the increased prevalence of valvular heart disease resulting from an ageing population. Since bioprosthetic heart valves (BHVs) continue to be the preferred replacement valve, there continues to be a strong need to develop better and more reliable BHVs through and improved the general understanding of BHV failure mechanisms. The major technological hurdle for the lifespan of the BHV implant continues to be the durability of the constituent leaflet biomaterials, which if improved can lead to substantial clinical impact...
December 2016: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/27496858/ross-procedure-for-aortic-valve-replacement-in-young-adults-preferred-procedure-or-double-double-toil-and-trouble
#10
EDITORIAL
Hartzell V Schaff
No abstract text is available yet for this article.
August 23, 2016: Circulation
https://www.readbyqxmd.com/read/27278376/partial-replacement-of-left-hemidiaphragm-in-dogs-by-either-cryopreserved-or-decellularized-heterograft-patch
#11
Hamid Reza Davari, Mohammad Bagher Rahim, Nader Tanideh, Mahsa Sani, Hamid Reza Tavakoli, Ali Reza Rasekhi, Ahmad Monabati, Omid Koohi-Hosseinabadi, Siavash Gholami
OBJECTIVES: Large diaphragmatic defects are still a challenging issue for reconstruction using either synthetic prosthesis or bioprosthesis. To evaluate the possibility of using diaphragm allograft as a natural bioprosthesis in humans, we conducted a two-group study and compared cryopreserved and decellularized diaphragmatic heterograft patched in a canine model. METHODS: At the end of organ harvesting from a human donor, the left hemidiaphragm was taken to the laboratory in phosphate-buffered saline solution...
October 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/26459726/liver-regeneration-using-decellularized-splenic-scaffold-a-novel-approach-in-tissue-engineering
#12
Jun-Xi Xiang, Xing-Long Zheng, Rui Gao, Wan-Quan Wu, Xu-Long Zhu, Jian-Hui Li, Yi Lv
BACKGROUND: The potential application of decellularized liver scaffold for liver regeneration is limited by severe shortage of donor organs. Attempt of using heterograft scaffold is accompanied with high risks of zoonosis and immunological rejection. We proposed that the spleen, which procured more extensively than the liver, could be an ideal source of decellularized scaffold for liver regeneration. METHODS: After harvested from donor rat, the spleen was processed by 12-hour freezing/thawing x 2 cycles, then circulation perfusion of 0...
October 2015: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/26422835/patient-derived-orthotopic-xenografts-better-mimic-of-metastasis-than-subcutaneous-xenografts
#13
Robert M Hoffman
The majority of human solid tumours do not metastasize when grown subcutaneously in immunocompromised mice; this includes patient-derived xenograft (PDX) models. However, orthotopic implantation of intact tumour tissue can lead to metastasis that mimics that seen in patients. These patient-derived orthotopic xenograft (PDOX) models have a long history and might better recapitulate human tumours than PDX models.
August 2015: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/26227964/inhibition-of-the-autocrine-il-6-jak2-stat3-calprotectin-axis-as-targeted-therapy-for-hr-her2-breast-cancers
#14
Ruth Rodriguez-Barrueco, Jiyang Yu, Laura P Saucedo-Cuevas, Mireia Olivan, David Llobet-Navas, Preeti Putcha, Veronica Castro, Eva M Murga-Penas, Ana Collazo-Lorduy, Mireia Castillo-Martin, Mariano Alvarez, Carlos Cordon-Cardo, Kevin Kalinsky, Matthew Maurer, Andrea Califano, Jose M Silva
HER2-positive (HER2(+)) breast adenocarcinomas are a heterogeneous group in which hormone receptor (HR) status influences therapeutic decisions and patient outcome. By combining genome-wide RNAi screens with regulatory network analysis, we identified STAT3 as a critically activated master regulator of HR(-)/HER2(+) tumors, eliciting tumor dependency in these cells. Mechanistically, HR(-)/HER2(+) cells secrete high levels of the interleukin-6 (IL-6) cytokine, inducing the activation of STAT3, which in turn promotes a second autocrine stimulus to increase S100A8/9 complex (calprotectin) production and secretion...
August 1, 2015: Genes & Development
https://www.readbyqxmd.com/read/26185002/colorectal-cancer-derived-tumor-spheroids-retain-the-characteristics-of-original-tumors
#15
Sun-Hwa Lee, Jun Hwa Hong, Hwan Ki Park, Jun Seok Park, Bo-Kyung Kim, Jung-Yi Lee, Ji Yun Jeong, Ghil Suk Yoon, Masahiro Inoue, Gyu-Seog Choi, In-Kyu Lee
Primary cultures of cancer cells are useful for developing personalized medicine. In this study, we characterized three lines of three-dimensional (3D) tumor spheroids established directly from tumor tissues of patients with colorectal cancers (CRCs). Each line mainly included EpCAM-positive cells and cells expressing putative cancer stem cell markers such as CD133, CD44, CD24, ALDH1, and LGR5. These characteristic stem cell markers remained identically for months in vitro. Short tandem repeat genotyping suggested that genetic fingerprints of these tumor spheroids were similar to those of the original tumor tissues from which they were derived...
October 10, 2015: Cancer Letters
https://www.readbyqxmd.com/read/26182628/carcinoid-heart-valve-disease-transcatheter-pulmonary-valve-in-valve-implantation-in-failing-biological-xenografts
#16
Lenard Conradi, Andreas Schaefer, Goetz C Mueller, Moritz Seiffert, Helmut Gulbins, Stefan Blankenberg, Hermann Reichenspurner, Hendrik Treede, Patrick Diemert
BACKGROUND AND AIM OF THE STUDY: Carcinoid heart valve disease (CHVD) occurs as the cardiac manifestation of carcinoid syndrome (also known as Hedinger's syndrome), which develops secondary to neuroendocrine tumor activity. CHVD almost exclusively affects right-sided heart valves, since circulating serotonin is metabolized by pulmonary endothelial cells, thus sparing left-sided valves. Replacement of the tricuspid and pulmonary valve is a well-established and feasible therapeutic option for these patients...
January 2015: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/26182627/advanced-integrity-preservation-technology-reduces-bioprosthesis-calcification-while-preserving-performance-and-safety
#17
COMPARATIVE STUDY
Angela B De La Fuente, Gregory A Wright, Jane M Olin, Francis G Duhay, Boguslaw Kapelak, Maciek Bochenek, Krzysztof Bartus, Jerzy Sadowski
BACKGROUND AND AIM OF THE STUDY: Structural valve deterioration (SVD) is the leading failure mode of bioprosthetic heart valves. The Edwards Integrity-Preservation (EIP™) technology was developed to permanently block tissue calcium-binding sites and allow for non-aqueous valve storage. The study aim was to evaluate the efficacy of tissue anti-calcification, valve performance, durability, and safety. METHODS: Bovine pericardial tissue with EIP technology was compared to industry-standard Carpentier-Edwards ThermaFix® and Xenologix® treatments...
January 2015: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/26182619/mitral-valve-repair-is-feasible-following-extensive-decalcification-and-reconstruction-of-the-atrioventricular-groove
#18
Joel Price, David Glineur, Laurent De Kerchove, Gebrine El Khoury
BACKGROUND AND AIM OF THE STUDY: Mitral annular calcification (MAC) represents a significant challenge in mitral valve (MV) surgery. Techniques to decalcify the mitral annulus significantly increase operative complexity and risk. MV repair can be particularly difficult in this setting. Mid-term outcomes following MV surgery with extensive annular decalcification were examined, with attention focused on the feasibility and outcomes of MV repair in this setting. METHODS: Among 1,485 patients undergoing MV surgery between 1999 and 2008 at the authors' institutions, 24 (1...
January 2015: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/26180079/maintaining-tumor-heterogeneity-in-patient-derived-tumor-xenografts
#19
REVIEW
John W Cassidy, Carlos Caldas, Alejandra Bruna
Preclinical models often fail to capture the diverse heterogeneity of human malignancies and as such lack clinical predictive power. Patient-derived tumor xenografts (PDX) have emerged as a powerful technology: capable of retaining the molecular heterogeneity of their originating sample. However, heterogeneity within a tumor is governed by both cell-autonomous (e.g., genetic and epigenetic heterogeneity) and non-cell-autonomous (e.g., stromal heterogeneity) drivers. Although PDXs can largely recapitulate the polygenomic architecture of human tumors, they do not fully account for heterogeneity in the tumor microenvironment...
August 1, 2015: Cancer Research
https://www.readbyqxmd.com/read/26168401/transcriptional-control-of-autophagy-lysosome-function-drives-pancreatic-cancer-metabolism
#20
Rushika M Perera, Svetlana Stoykova, Brandon N Nicolay, Kenneth N Ross, Julien Fitamant, Myriam Boukhali, Justine Lengrand, Vikram Deshpande, Martin K Selig, Cristina R Ferrone, Jeff Settleman, Gregory Stephanopoulos, Nicholas J Dyson, Roberto Zoncu, Sridhar Ramaswamy, Wilhelm Haas, Nabeel Bardeesy
Activation of cellular stress response pathways to maintain metabolic homeostasis is emerging as a critical growth and survival mechanism in many cancers. The pathogenesis of pancreatic ductal adenocarcinoma (PDA) requires high levels of autophagy, a conserved self-degradative process. However, the regulatory circuits that activate autophagy and reprogram PDA cell metabolism are unknown. Here we show that autophagy induction in PDA occurs as part of a broader transcriptional program that coordinates activation of lysosome biogenesis and function, and nutrient scavenging, mediated by the MiT/TFE family of transcription factors...
August 20, 2015: Nature
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