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https://www.readbyqxmd.com/read/28086988/computed-tomographic-findings-and-treatment-of-a-bull-with-pituitary-gland-abscess
#1
Ueli Braun, Alexandra Malbon, Manon Kochan, Barbara Riond, Fredi Janett, Cornelia Iten, Matthias Dennler
BACKGROUND: In cattle, the prognosis of brain abscess is unfavourable and treatment is therefore not recommended. To the knowledge of the authors, there has been no report of successful treatment of a brain abscess in cattle.This report describes the clinical, computed tomographic and postmortem findings in a Holstein-Friesian bull with a hypophyseal abscess. CASE REPORT: The main clinical findings were generalised ataxia, ptyalism, prolapse of the tongue, dropped jaw, dysphagia, head tilt and unilateral ptosis...
January 13, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28068788/a-double-blind-randomized-placebo-controlled-trial-of-lactobacillus-helveticus-and-bifidobacterium-longum-for-the-symptoms-of-depression
#2
Amy R Romijn, Julia J Rucklidge, Roeline G Kuijer, Chris Frampton
OBJECTIVES: This trial investigated whether probiotics improved mood, stress and anxiety in a sample selected for low mood. We also tested whether the presence or severity of irritable bowel syndrome symptoms, and levels of proinflammatory cytokines, brain-derived neurotrophic factor and other blood markers, would predict or impact treatment response. METHOD: Seventy-nine participants (10 dropouts) not currently taking psychotropic medications with at least moderate scores on self-report mood measures were randomly allocated to receive either a probiotic preparation (containing Lactobacillus helveticus and Bifidobacterium longum) or a matched placebo, in a double-blind trial for 8 weeks...
January 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28068373/stress-dependent-changes-in-the-cacybp-sip-interacting-protein-s100a6-in-the-mouse-brain
#3
Katarzyna Bartkowska, Izabela Swiatek, Agata Aniszewska, Ewelina Jurewicz, Kris Turlejski, Anna Filipek, Rouzanna L Djavadian
The CacyBP/SIP target S100A6 is widely present in the nervous system, and its up-regulation is associated with certain neurodegenerative diseases. Here, we examined the involvement of S100A6 protein in stress responses in mice. Using Western blotting, we observed a marked change in brainstem structures, whereby stressed mice showed approximately one-third the protein level produced in the control group. A decreased level of S100A6 protein in stressed animals was also detected in the olfactory bulb and the cerebellum and stress-related structures such as the hippocampus and the hypothalamus...
2017: PloS One
https://www.readbyqxmd.com/read/28065844/effects-of-the-chronic-restraint-stress-induced-depression-on-reward-related-learning-in-rats
#4
Pan Xu, Kezhu Wang, Cong Lu, Liming Dong, Yixi Chen, Qiong Wang, Zhe Shi, Yanyan Yang, Shanguang Chen, Xinmin Liu
Chronic mild or unpredictability stress produces a persistent depressive-like state. The main symptoms of depression include weight loss, despair, anhedonia, diminished motivation and mild cognition impairment, which could influence the ability of reward-related learning. In the present study, we aimed to evaluate the effects of chronic restraint stress on the performance of reward-related learning of rats. We used the exposure of repeated restraint stress (6h/day, for 28days) to induce depression-like behavior in rats...
January 5, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28064424/gender-related-hippocampal-proteomics-study-from-young-rats-after-chronic-unpredicted-mild-stress-exposure
#5
Lin-Na Ning, Teng Zhang, Jiang Chu, Na Qu, Li Lin, Ying-Yan Fang, Yan Shi, Peng Zeng, Er-Li Cai, Xiao-Ming Wang, Qun Wang, You-Ming Lu, Xin-Wen Zhou, Qi Zhang, Qing Tian
Clinical data have shown women are more susceptible to depression. This study was performed to identify differentially regulated proteins from hippocampus in chronic unpredicted mild stress (CUMS)-exposed male and female young rats. After 7 weeks of CUMS, depressed male (M-D) and female rats (F-D) and unstressed male (M-C) and female controls (F-C) were studied. By proteomics analysis, 74 differential proteins in F-C/M-C, 79 in F-D/M-D, 77 in F-D/F-C, and 32 in M-D/M-C were found. Further, the synapse-related proteins, cytoskeleton protein tau, and stress-related kinases in hippocampus were assayed by Western blotting...
January 7, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28063309/qualitative-and-quantitative-changes-in-phospholipids-and-proteins-investigated-by-spectroscopic-techniques-in-animal-depression-model
#6
J Depciuch, M Sowa-Kucma, G Nowak, M Papp, P Gruca, P Misztak, M Parlinska-Wojtan
Depression becomes nowadays a high mortality civilization disease with one of the major causes being chronic stress. Raman, Fourier Transform Infra Red (FTIR) and Ultraviolet-Visible (UV-vis) spectroscopies were used to determine the changes in the quantity and structure of phospholipids and proteins in the blood serum of rats subjected to chronic mild stress, which is a common animal depression model. Moreover, the efficiency of the imipramine treatment was evaluated. It was found that chronic mild stress not only damages the structure of the phospholipids and proteins, but also decreases their level in the blood serum...
December 28, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28062256/dehydroepiandrosterone-increases-the-number-and-dendrite-maturation-of-doublecortin-cells-in-the-dentate-gyrus-of-middle-age-male-wistar-rats-exposed-to-chronic-mild-stress
#7
J J Herrera-Pérez, L Martínez-Mota, G Jiménez-Rubio, L Ortiz-López, E A Cabrera-Muñoz, N Galindo-Sevilla, E Zambrano, F Hernández-Luis, G B Ramírez-Rodríguez, M Flores-Ramos
Aging increases the vulnerability to stress and risk of developing depression. These changes have been related to a reduction of dehydroepiandrosterone (DHEA) levels, an adrenal steroid with anti-stress effects. Also, adult hippocampal neurogenesis decreases during aging and its alteration or impaired is related to the development of depression. Besides, it has been hypothesized that DHEA increases the formation of new neurons. However, it is unknown whether treatment with DHEA in aging may stimulate the dendrite maturation of newborn neurons and reversing depressive-like signs evoked by chronic stress exposure...
January 4, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28054037/gene-expression-alterations-in-the-medial-prefrontal-cortex-and-blood-cells-in-a-mouse-model-of-depression-during-menopause
#8
Shigeo Miyata, Masashi Kurachi, Noriko Sakurai, Yuchio Yanagawa, Yasuki Ishizaki, Masahiko Mikuni, Masato Fukuda
AIMS: The prevalence of major depressive disorder (MDD) is higher in women than in men, and this may be due to the decline in estrogen levels that occurs during the menopausal transition. We studied the biological alterations in the medial prefrontal cortex (mPFC), which is a region that is highly implicated in the neurobiology of MDD, and the blood cells (BCs) of ovariectomized (OVX) mice subjected to chronic mild stress (CMS), which represents a mouse model of depression during menopause...
December 2016: Heliyon
https://www.readbyqxmd.com/read/28043860/differential-heart-rate-variability-and-physiological-responses-associated-with-accumulated-short-and-long-term-stress-in-rodents
#9
Sunghee E Park, Dajeong Park, Kang-Il Song, Joon-Kyung Seong, Seok Chung, Inchan Youn
In this study, we tested the hypothesis that chronic stress has cumulative effects over time on heart rate variability (HRV) and physiological responses in a rodent model of chronic mild stress. Rats were exposed to either short-term (2weeks) or long-term (4weeks) stress, followed by a 1-week recovery period. Controls were normally housed rats that did not undergo the stress procedure. For electrocardiogram recordings, transmitters were implanted in all rats 10days before the onset of the experiment to allow recovery from surgery...
December 30, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/28043834/sub-anesthetic-doses-of-ketamine-exert-antidepressant-like-effects-and-upregulate-the-expression-of-glutamate-transporters-in-the-hippocampus-of-rats
#10
Xianlin Zhu, Gang Ye, Zaiping Wang, Jie Luo, Xuechao Hao
Clinical studies on the role of the glutamatergic system in the pathogenesis of depression found that ketamine induces an antidepressant response, but the molecular mechanisms remain unclear. The present study investigated the effects of sub-anesthetic doses of ketamine on the glutamate reuptake function in the rat hippocampus. Chronic unpredictable mild stress (CUMS) was applied to construct animal models of depression. Sixty adult male Sprague-Dawley rats were randomly assigned to 5 groups and received a different regimen of CUMS and ketamine (10, 25, and 50mg/kg) treatment...
December 30, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/28024269/aromatase-changes-in-depression-a-postmortem-and-animal-experimental-study
#11
Juan-Li Wu, Yang He, Radovan Hrubý, Rawien Balesar, Yang-Jian Qi, Lei Guo, Zhong Ren, Qiong-Bin Zhu, Man-Li Huang, Dick F Swaab, Ai-Min Bao
A hyperactive hypothalamo-pituitary-adrenal (HPA) axis is a prominent feature in depression. It has been shown that androgens inhibit HPA activity and that estrogens stimulate it. We have therefore investigated, in human postmortem hypothalamus, whether depression features an increase in aromatase, which is the rate-limiting enzyme for the conversion of androgens to estrogens. In addition, we have tested the effect of an aromatase inhibitor on depression-like symptoms in a frequently used animal model for depression...
November 30, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28017784/ecophysiological-perspectives-on-engineered-nanomaterial-toxicity-in-fish-and-crustaceans
#12
Neal Ingraham Callaghan, Tyson James MacCormack
Engineered nanomaterials (ENMs) are incorporated into numerous industrial, clinical, food, and consumer products and a significant body of evidence is now available on their toxicity to aquatic organisms. Environmental ENM concentrations are difficult to quantify, but production and release estimates suggest wastewater treatment plant effluent levels ranging from 10(-4) to >10(1)μgL(-1) for the most common formulations by production volume. Bioavailability and ENM toxicity are heavily influenced by water quality parameters and the physicochemical properties and resulting colloidal behaviour of the particular ENM formulation...
December 23, 2016: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28017597/repeated-restraint-stress-lowers-the-threshold-for-response-to-third-ventricle-crf-administration
#13
Ruth B S Harris
Rats and mice exposed to repeated stress or a single severe stress exhibit a sustained increase in energetic, endocrine, and behavioral response to subsequent novel mild stress. This study tested whether the hyper-responsiveness was due to a lowered threshold of response to corticotropin releasing factor (CRF) or an exaggerated response to a standard dose of CRF. Male Sprague-Dawley rats were subjected to 3h of restraint on each of 3 consecutive days (RRS) or were non-restrained controls. RRS caused a temporary hypophagia but a sustained reduction in body weight...
December 23, 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/28012396/antidepressant-like-effects-of-hydrolysable-tannins-of-terminalia-catappa-leaf-extract-via-modulation-of-hippocampal-plasticity-and-regulation-of-monoamine-neurotransmitters-subjected-to-chronic-mild-stress-cms
#14
Y Chandrasekhar, E M Ramya, K Navya, G Phani Kumar, K R Anilakumar
Terminalia catappa L. belonging to Combretaceae family is a folk medicine, known for its multiple pharmacological properties, but the neuro-modulatory effect of TC against chronic mild stress was seldom explored. The present study was designed to elucidate potential antidepressant-like effect of Terminalia cattapa (leaf) hydro-alcoholic extract (TC) by using CMS model for a period of 7 weeks. Identification of hydrolysable tannins was done by using LC-MS. After the CMS exposure, mice groups were administered with imipramine (IMP, 10mg/kg, i...
December 21, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28009452/metabolic-profiles-revealed-synergistically-antidepressant-effects-of-lilies-and-rhizoma-anemarrhenae-in-a-rat-model-of-depression
#15
Hongli Du, Hongxia Zhao, Xueli Lai, Qishan Lin, Zhenyu Zhu, Yifeng Chai, Ziyang Lou
Depression is the predominant cause of illness and disability. We applied untargeted metabolomics using mass spectrometry to identify metabolic signatures associated with depression in serum and explored the antidepressant effects of Lilies and Rhizoma Anemarrhenae on an experimental model of chronic unpredictable mild stress (CUMS). Meanwhile metabolomics based on UHPLC-Q-TOF-MS, was used to study the change in metabolites in CUMS rat serum and to evaluate the effects of Anemarrhena Rhizoma, Lilies (alone and in combination)...
December 23, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28004508/the-molecular-basis-of-jaundice-an-old-symptom-revisited
#16
Silvia Gazzin, Flora Masutti, Libor Vitek, Claudio Tiribelli
Increased serum bilirubin level is a widely used diagnostic marker for hepatic illnesses. Nevertheless, mild elevation of unconjugated serum bilirubin (such as in Gilbert syndrome) has been recently demonstrated to correlate with low risk of chronic pro-inflammatory and/or oxidative stress-mediated diseases. In accord, a low serum bilirubin level has emerged as an important predisposing factor or a biomarker of these pathologic conditions including cardiovascular, tumor, and possibly neurodegenerative diseases...
December 22, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27994633/electroacupuncture-restores-5-ht-system-deficit-in-chronic-mild-stress-induced-depressed-rats
#17
Dongmei Duan, Ya Tu, Xiuyan Yang, Ping Liu
Objective. The current study is designed to investigate the antidepressant efficacy of electroacupuncture (EA) treatment by evaluating its effect on the synthesis, metabolism, reuptake, and receptors of 5-hydroxytryptamine (5-HT), so as to clarify the molecular mechanisms of EA for antidepression. Materials and Methods. Solitary combined with the chronic unpredictable mild stress (CUMS) was used to establish the rat model with depression. The depressed rats were supplied with EA treatment for 4 weeks, and the behavior change and the following indices including 5-HT, 5-hydroxyindoleacetic acid (5-HIAA), monoamine oxidase A (MAO-A), tryptophan hydroxylase (TPH), 5-HT transporter (SERT), 5-HT1A, and 5-HT2A in hippocampus and prefrontal cortex were examined...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27988841/so4-uptake-and-catalase-role-in-preconditioning-after-h2o2-induced-oxidative-stress-in-human-erythrocytes
#18
Rossana Morabito, Alessia Remigante, Maria Letizia Di Pietro, Antonino Giannetto, Giuseppina La Spada, Angela Marino
Preconditioning (PC) is an adaptive response to a mild and transient oxidative stress, shown for the first time in myocardial cells and not described in erythrocytes so far. The possible adaptation of human erythrocytes to hydrogen peroxide (H2O2)-induced oxidative stress has been here verified by monitoring one of band 3 protein functions, i.e., Cl(-)/HCO3(-) exchange, through rate constant for SO4(=) uptake measurement. With this aim, erythrocytes were exposed to a mild and transient oxidative stress (30 min to either 10 or 100 μM H2O2), followed by a stronger oxidant condition (300- or, alternatively, 600-μM H2O2 treatment)...
December 17, 2016: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/27981184/pioglitazone-a-ppar%C3%AE-agonist-rescues-depression-associated-with-obesity-using-chronic-unpredictable-mild-stress-model-in-experimental-mice
#19
Yeshwant Kurhe, Radhakrishnan Mahesh
Pioglitazone, a peroxisome proliferator activated receptor gamma (PPARγ) agonist belonging to thiazolidinedione class, is mainly used in diabetes mellitus. Obese subjects are twice likely to become depressed than non-obese individuals. The biological mechanisms linking depression with obesity still remain poorly understood and there is immense need for better therapeutic intervention against such co-morbid disorders. The present study investigates the effect of pioglitazone on the chronic unpredictable mild stress (CUMS) induced depression in obese mice by using behavioral tests and biochemical estimations...
June 2016: Neurobiology of Stress
https://www.readbyqxmd.com/read/27975125/antidepressant-like-activity-of-the-neuropeptide-y-y5-receptor-antagonist-lu-aa33810-behavioral-molecular-and-immunohistochemical-evidence
#20
Helena Domin, Bernadeta Szewczyk, Bartłomiej Pochwat, Monika Woźniak, Maria Śmiałowska
RATIONALE: It has recently been found that chronic treatment with the highly selective, brain-penetrating Y5 receptor antagonist, Lu AA33810 [N-[[trans-4-[(4,5-dihydro [1] benzothiepino[5,4-d] thiazol-2-yl) amino] cyclohexyl]methyl]-methanesulfonamide], produces antidepressant-like effects in the rat chronic mild stress model. OBJECTIVE: In the present study, we investigated the possible antidepressant-like activity of Lu AA33810 in rats subjected to glial ablation in the prefrontal cortex (PFC) by the gliotoxin L-AAA, which is an astroglial degeneration model of depression...
December 14, 2016: Psychopharmacology
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