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https://www.readbyqxmd.com/read/29775613/suppression-of-nlrp3-inflammasome-attenuates-stress-induced-depression-like-behavior-in-nlgn3-deficient-mice
#1
Ze-Qun Li, Zhi-Yuan Yan, Bo-Jun Lan, Yi-Qun Dong, Ye Xiong
Depression, regulated by central nervous system (CNS), is a significant inflammatory disorder. Neuroligin3 (NLGN3) has been implicated in brain functions. In the study, a chronic unpredictable mild stress (CUMS) model in wild type (WT) or NLGN3-knockout (KO) mice was established to explore the role of NLGN3 in regulating depression and to reveal the underlying molecular mechanism. The results indicated that NLGN3-knockout markedly reversed the loss of body weight, the reduction of sucrose consumption, the decrease of immobile time in the forced swimming tests (FST) and tail suspension tests (TST) induced by CUMS paradigm...
May 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29765402/tlr4-nf-%C3%AE%C2%BA-b-signal-involved-in-depressive-like-behaviors-and-cytokine-expression-of-frontal-cortex-and-hippocampus-in-stressed-c57bl-6-and-ob-ob-mice
#2
Yihe Wang, Jingjing Xu, Yuan Liu, Ziyang Li, Xiaohong Li
Studies found that elevated levels of cytokines such as interleukin- (IL-) 1 β , IL-6, and tumor necrosis factor- α (TNF- α ) are closely associated with the pathogenesis of depression. Obesity providing a low-grade inflammation state was proposed to be implicated in susceptibility to depression in obesity. However, the alterations of cytokines and the TLR4-NF- κ B signal in the brain of normal-weight and obese mice under stress have not been fully elucidated. This study used chronic unpredictable mild stress (CUMS) to induce a depressive-like behavior in an animal model and examine depressive-like behaviors, memory changes, and serum corticosterone levels, as well as the expressions of cytokines and NF- κ B in the frontal cortex and hippocampus...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29752492/novel-antidepressant-effects-of-paeonol-alleviate-neuronal-injury-with-concomitant-alterations-in-bdnf-rac1-and-rhoa-levels-in-chronic-unpredictable-mild-stress-rats
#3
Xiu-Ling Zhu, Jing-Jing Chen, Fei Han, Chuan Pan, Ting-Ting Zhuang, Ya-Fei Cai, Ya-Ping Lu
RATIONALE: Increasing evidence has suggested that major depressive disorder (MDD) is highly associated with brain-derived neurotrophic factor (BDNF) levels, dendrites atrophy, and loss of dendritic spines, especially in emotion-associated brain regions including the hippocampus. Paeonol is a kind of polyphenols natural product with a variety of therapeutic effects. Recent studies have reported its antidepressant effects. However, it is unclear what signaling pathways contribute to improve MDD...
May 12, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29751542/xiaoyaosan-improves-depressive-like-behaviors-in-mice-through-regulating-apelin-apj-system-in-hypothalamus
#4
Zhiyi Yan, Haiyan Jiao, Xiufang Ding, Qingyu Ma, Xiaojuan Li, Qiuxia Pan, Tingye Wang, Yajing Hou, Youming Jiang, Yueyun Liu, Jiaxu Chen
Background: The apelin-APJ system has been considered to play a crucial role in HPA axis function, and how the traditional Chinese compound prescription Xiaoyaosan regulates the apelin-APJ system as a supplement to treat depressive disorders. Objective: To investigate the depression-like behaviors and expression of apelin and APJ in hypothalamus of chronic unpredictable mild stress (CUMS) mice and study whether these changes related to the regulation of Xiaoyaosan. Methods: 60 adult C57BL/6J mice were randomly divided into four groups, including control group, CUMS group, Xiaoyaosan treatment group and fluoxetine treatment group...
May 3, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29749518/effects-of-chronic-unpredictable-mild-stress-on-ovarian-reserve-in-female-rats-feasibility-analysis-of-a-rat-model-of-premature-ovarian-failure
#5
Xiao-Yan Fu, Hao-Hao Chen, Ning Zhang, Ming-Xing Ding, Ying-Er Qiu, Xiao-Ming Pan, Yuan-Shu Fang, Yi-Ping Lin, Qun Zheng, Wen-Qian Wang
Premature ovarian failure (POF) results from a number of disorders. The POF model is primarily based on chemotherapeutic injury, and hence is not suitable for assessing the effects of chronic stress on ovarian function. Therefore, improved animal models are required to analyze the effects of chronic stress on ovarian reserve. The feasibility of the chronic unpredictable mild stress (CUMS) method for establishing a model of POF was examined. The depressive behavior exhibited by rats was evaluated with the open field and sucrose preference tests...
May 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29749116/neonatal-pain-and-stress-disrupts-later-life-pavlovian-fear-conditioning-and-sensory-function-in-rats-evidence-for-a-two-hit-model
#6
Seth M Davis, Makaela Rice, Jacob Rudlong, Victoria Eaton, Tamara King, Michael A Burman
Early life trauma has been linked to increased risks for anxiety, depression, and chronic pain. We used rodent models of acute and inflammatory neonatal pain to explore effects on fear conditioning and somatosensory function. Hindpaw needle pricks or handling on postnatal days (PNDs) 1-7 caused lasting impacts on affective and somatosensory function when assessed at later ages, PNDs 24 (postweaning), 45 (adolescence), or 66 (adulthood). First, auditory, but not contextual, freezing was mildly disrupted regardless of age...
May 10, 2018: Developmental Psychobiology
https://www.readbyqxmd.com/read/29745041/cluster-analysis-of-multiple-chronic-conditions-associated-with-urinary-incontinence-among-women-in-the-usa
#7
Alayne D Markland, Camille P Vaughan, Ike S Okosun, Patricia S Goode, Kathryn L Burgio, Theodore M Johnson
OBJECTIVE: To identify patterns of prevalent chronic medical conditions among women with urinary incontinence (UI). MATERIALS AND METHODS: We combined cross-sectional data from the 2005-2006 to 2011-2012 US National Health and Nutrition Examination Surveys, and identified 3 800 women with UI and data on 12 chronic conditions. Types of UI included stress UI (SUI), urgency UI (UUI), and mixed stress and urgency UI (MUI). We categorized UI as mild, moderate or severe using validated measures...
May 9, 2018: BJU International
https://www.readbyqxmd.com/read/29743870/absence-of-wdr13-gene-predisposes-mice-to-mild-social-isolation-chronic-stress-leading-to-depression-like-phenotype-associated-with-differential-expression-of-synaptic-proteins
#8
Shiladitya Mitra, Ghantasala S Sameer Kumar, B Jyothi Lakshmi, Suman Thakur, Satish Kumar
We earlier reported that the male mice lacking the Wdr13 gene ( Wdr13 -/0 ) showed mild anxiety, better memory retention, and up-regulation of synaptic proteins in the hippocampus. With increasing evidences from parallel studies in our laboratory about the possible role of Wdr13 in stress response, we investigated its role in brain. We observed that Wdr13 transcript gets up-regulated in the hippocampus of the wild-type mice exposed to stress. To further dissect its function, we analyzed the behavioral and molecular phenotypes of Wdr13 -/0 mice when subjected to mild chronic psychological stress, namely; mild (attenuated) social isolation...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29743387/suhexiang-essential-oil-inhalation-produces-antidepressant-and-anxiolytic-like-effects-in-adult-mice
#9
Min Liang, Yuru Du, Wenjing Li, Xi Yin, Ni Yang, Anran Qie, Tyler W LeBaron, Jiayu Zhang, Haiying Chen, Haishui Shi
SuHeXiang (SHX) has been used to treat a wide range of diseases, including those related to the central nervous system. However, the effects of SHX on mood disorders are still elusive. This study aimed to investigate the effects of SHX essential oil on stress-induced depression of mice. In an acute stress-induced depression model, mice inhaled vehicle (1% Tween80) for 10 min or 10% SHX for 10 or 30 min once daily for 12 continuous days. In the chronic mild stress (CMS)-induced depression model, mice were exposed to a 28-d CMS treatment...
May 9, 2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29736132/the-level-of-nesfatin-1-in-a-mouse-gastric-cancer-model-and-its-role-in-gastric-cancer-comorbid-with-depression
#10
Nan Zhang, Jiangbo Li, Huiling Wang, Ling Xiao, Yanyan Wei, Jing He, Gaohua Wang
Background: The incidence of depressive symptoms is higher in cancer patients. And depression can also affect the occurrence, development and outcome of cancer through the neuroendocrine-immune-network system. Objective: To study the level of Nesfatin-1 in the plasma and brain tissue and its role in the pathogenesis in gastric cancer comorbid with depression using a mouse gastric cancer model. Methods: 18 mice were randomly divided into the normal control group (NCG), gastric cancer without stress model group (GCNS), and gastric cancer combined with stress model group (GCS)...
April 25, 2018: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/29725904/chronic-mild-stress-alters-kynurenine-pathways-changing-the-glutamate-neurotransmission-in-frontal-cortex-of-rats
#11
David Martín-Hernández, Hiram Tendilla-Beltrán, José L M Madrigal, Borja García-Bueno, Juan C Leza, Javier R Caso
Immune stimulation might be involved in the pathophysiology of major depressive disorder (MDD). This stimulation induces indoleamine 2,3-dioxygenase (IDO), an enzyme that reduces the tryptophan bioavailability to synthesize serotonin. IDO products, kynurenine metabolites, exert neurotoxic/neuroprotective actions through glutamate receptors. Thus, we study elements of these pathways linked to kynurenine metabolite activity examining whether antidepressants (ADs) can modulate them. Male Wistar rats were exposed to chronic mild stress (CMS), and some of them were treated with ADs...
May 3, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29723593/sex-dependent-impact-of-different-degrees-of-maternal-separation-experience-on-oft-behavioral-performances-after-adult-chronic-unpredictable-mild-stress-exposure-in-rats
#12
Yanyan Wei, Gaohua Wang, Huiling Wang, Jing He, Nan Zhang, Zuotian Wu, Ling Xiao, Can Yang
Early-life social-environmental factors are important for normal development, and different degrees of early-life stress experience have different impacts on adult behaviors and stress responsiveness. The aim of present study was to investigate the long-term effects of different degrees of maternal separation (MS) on male and female rats and subsequent responsiveness to chronic unpredictable mild stress (CUMS) exposure in adults. Sprague-Dawley (SD) newborn pups were exposed to either 15 min/day of MS (MS15), 360 min/day of MS (MS360) or no separation (NS) during postnatal day (PND)4-PND10...
April 30, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29715537/resveratrol-prevents-cognitive-deficits-induced-by-chronic-unpredictable-mild-stress-sirt1-mir-134-signalling-pathway-regulates-creb-bdnf-expression-in-hippocampus-in-vivo-and-in-vitro
#13
Jun Shen, Linling Xu, Chujie Qu, Huimin Sun, Junjian Zhang
Chronic unpredictable mild stress (CUMS) leads to neuropsychiatric disorders, such as depression, anxiety and cognitive impairment. Resveratrol is a natural polyphenol existed in polygonum cuspidatum and has been demonstrated to be a potent activator of Sirtuin 1 (Sirt1). Previous studies reported that resveratrol treatment ameliorated CUMS-induced depressive-like behavior and cognitive deficits through upregulating cAMP response element-binding protein (CREB) and brain derived neurotrophic factor (BDNF) expression...
April 28, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29715268/job-exposure-to-the-public-in-relation-with-alcohol-tobacco-and-cannabis-use-findings-from-the-constances-cohort-study
#14
Guillaume Airagnes, Cédric Lemogne, Marcel Goldberg, Nicolas Hoertel, Yves Roquelaure, Frédéric Limosin, Marie Zins
OBJECTIVES: To examine the associations between job exposure to the public (e.g., customers, guests, users of a public service, patients) and alcohol, tobacco and cannabis use. METHODS: From the French population-based CONSTANCES cohort, 16,566 men and 17,426 women currently working were included between 2012 and 2016. They reported their exposure to the public (daily versus no daily), and among the daily exposed participants (10,323 men and 13,318 women), the frequency of stressful exposure (often versus rarely)...
2018: PloS One
https://www.readbyqxmd.com/read/29713785/regulation-of-somatostatin-receptor-2-in-the-context-of-antidepressant-treatment-response-in-chronic-mild-stress-in-rat
#15
Agata Faron-Górecka, Maciej Kuśmider, Joanna Solich, Magdalena Kolasa, Paulina Pabian, Piotr Gruca, Irena Romańska, Dariusz Żurawek, Marta Szlachta, Mariusz Papp, Lucyna Antkiewicz-Michaluk, Marta Dziedzicka-Wasylewska
RATIONALE: The role of somatostatin and its receptors for the stress-related neuropsychiatric disorders has been widely raised. Recently, we have also demonstrated the involvement of somatostatin receptor type 2-sst2R and dopamine receptor type 2-D2R in stress. OBJECTIVE: In this context, we decided to find if these receptors are involved in response to antidepressant treatment in animal model of depression-chronic mild stress (CMS). METHODS: Here, we report data obtained following 7-week CMS procedure...
April 30, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29712539/the-ethanolic-extract-obtained-from-campomanesia-pubescens-d-c-o-berg-fruits-exerts-anxiolytic-and-antidepressant-effects-on-chronic-mild-stress-model-and-on-anxiety-models-in-wistar-rats-behavioral-evidences
#16
Gustavo Roberto Villas Boas, Ana Paula Stefanello da Silveira, Brunna Charlla Feitosa Farinelli, Claudia Andréa Lima Cardoso, Emely Arce, Silvia Aparecida Oesterreich
OBJECTIVES: Campomanesia pubescens (DC) O.BERG (Myrtaceae) fruits contain high levels of flavonoids and are widely consumed by the South American population. In the central nervous system (CNS), some flavonoids act as modulators of GABA-A receptors and monoamine oxidase inhibitors, resulting in anxiolytic antidepressants effects, respectively. The objective of the present study was to evaluate the anxiolytic and antidepressant effects of ethanolic extract of C. pubescens fruits (EEFCP) in rats...
May 1, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29707580/chronic-unpredictable-mild-stress-causing-cardiac-and-thoracic-spinal-cord-electrophysiological-abnormalities-may-be-associated-with-increased-cardiac-expression-of-serotonin-and-growth-associated-protein-43-in-rats
#17
Zhengjiang Liu, Hua Liu, Zhi Huan Zeng
Background: The aim of this study was to investigate the potential mechanisms by which chronic unpredictable mild stress (CMS) might induce cardiovascular disease. Methods: Twenty male Sprague-Dawley rats (weighing 180-250 g) were divided into the CMS group (CMS for 3 weeks) and control group ( n = 10/group). Sucrose solution consumption, sucrose solution preference rate, and the open field test (horizontal and vertical movements) were used to confirm the establishment of the CMS model...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29704115/bdnf-trkb-pathway-mediates-the-antidepressant-like-role-of-h-2-s-in-cums-exposed-rats-by-inhibition-of-hippocampal-er-stress
#18
Le Wei, Li-Yuan Kan, Hai-Ying Zeng, Yi-Yun Tang, Hong-Lin Huang, Ming Xie, Wei Zou, Chun-Yan Wang, Ping Zhang, Xiao-Qing Tang
Our previous works have shown that hydrogen sulfide (H2 S) significantly attenuates chronic unpredictable mild stress (CUMS)-induced depressive-like behaviors and hippocampal endoplasmic reticulum (ER) stress. Brain-derived neurotrophic factor (BDNF) generates an antidepressant-like effect by its receptor tyrosine protein kinase B (TrkB). We have previously found that H2 S upregulates the expressions of BDNF and p-TrkB in the hippocampus of CUMS-exposed rats. Therefore, the present work was to explore whether BDNF/TrkB pathway mediates the antidepressant-like role of H2 S by blocking hippocampal ER stress...
April 27, 2018: Neuromolecular Medicine
https://www.readbyqxmd.com/read/29698729/axonal-transport-proteins-and-depressive-like-behavior-following-chronic-unpredictable-mild-stress-in-male-rat
#19
Fatemeh Bakhtiarzadeh, Arezo Nahavandi, Mina Goudarzi, Sakine Shirvalilou, Kamran Rakhshan, Somayeh Niknazar
BACKGROUND: A common mood disorder, depression has long been considered a leading cause of disability worldwide. Chronic stress is involved in the development of various psychiatric diseases including major depressive disorder. Stress can induce depressive-like symptoms and initiate neurodegenerative processes in the brain. The neurodegenerative theory of depression holds impaired axonal transport as a negative factor in neural survival. Axonal transport is a critical mechanism for normal neuronal function, playing crucial roles in axon growth, neurotransmitter secretion, normal mitochondrial function and neural survival...
April 23, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29689422/consequences-of-a-double-hit-of-stress-during-the-perinatal-period-and-midlife-in-female-rats-mismatch-or-cumulative-effect
#20
Gilles Van Camp, Jenny Cigalotti, Hammou Bouwalerh, Jérôme Mairesse, Eleonora Gatta, Paola Palanza, Stefania Maccari, Sara Morley-Fletcher
The interplay between experiences during critical developmental periods and later adult life is crucial in shaping individual variability in stress coping strategies. Exposure to stressful events in early life has strongly programs an individual's phenotype and adaptive capabilities. Until now, studies on programming and reversal strategies in early life stress animal models have been essentially limited to males. By using the perinatal stress (PRS) rat model (a model more sensitive to aging changes) in middle-aged females, we investigated the behavioral and endocrine responses following exposure in later life to an unpredictable chronic mild stress (uCMS) condition for six weeks...
April 14, 2018: Psychoneuroendocrinology
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