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https://www.readbyqxmd.com/read/28644824/mechanism-underlying-acupuncture-ameliorated-depressive-behaviors-by-enhancing-glial-glutamate-transporter-in-chronic-unpredictable-mild-stress-cums-rats
#1
Ding Luo, Rui Ma, Yanan Wu, Xuechun Zhang, Yue Liu, Lin Wang, Wenbin Fu
BACKGROUND Major depressive disorder (MDD) is a recurrent mental illness worldwide. The glutamatergic neurotransmission system is now a target for antidepressant therapy because it takes part in synaptic plasticity and cognition in physical condition and has a potential excitatory neurotoxicity in pathological conditions. Glial glutamate transporter EAAT2 performs 90% of Glu neurotransmission. Therefore, the aim of the study was to evaluate the effect of acupuncture on depressive behaviors and EAAT2 in CUMS...
June 23, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28644453/evaluation-of-the-neutrophil-lymphocyte-ratio-as-an-indicator-of-chronic-distress-in-the-laboratory-mouse
#2
Debra L Hickman
When evaluating the effect of husbandry and biomethodologies on the well-being of laboratory mice, it is critical to utilize measurements that allow the distinguishing of acute stress from chronic stress. One of the most common measurements of stress in laboratory animals is the corticosterone assessment. However, while this measurement provides a highly accurate reflection of the animal's response to acute stressors, its interpretation is more prone to error when evaluating the effect of chronic stress. This study evaluated the use of the neutrophil:lymphocyte (NE:LY) ratio as an assessment of chronic stress in male and female C57Bl/6N mice as compared to serum corticosterone...
June 23, 2017: Lab Animal
https://www.readbyqxmd.com/read/28635080/neuroadaptations-of-presynaptic-and-postsynaptic-gabab-receptor-function-in-the-paraventricular-nucleus-in-response-to-chronic-unpredictable-stress
#3
Yonggang Gao, Jing-Jing Zhou, Yun Zhu, Li Wang, Therese A Kosten, Xiangjian Zhang, De-Pei Li
BACKGROUND: Chronic stress induces an impaired GABAA (γ-aminobutyric acid type A) receptor-mediated inhibition in the hypothalamic paraventricular nucleus (PVN). It is not clear whether GABAB receptor function is altered in chronic stress. We hypothesize that chronic stress alters GABAB receptor function in PVN corticotrophin-releasing hormone (CRH) neurons to control hypothalamus-pituitary-adrenal (HPA) axis activity. EXPERIMENTAL APPROACH: Whole cell patch-clamp recording was performed on PVN-CRH neurons expressing eGFP driven by CRH promoter in brain slices from unstressed rats and rats that had been subjected to chronic unpredictable mild stress (CUMS)...
June 20, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28629846/hippocampal-gr-and-cb1-mediated-mglur5-differentially-produces-susceptibility-and-resilience-to-acute-and-chronic-mild-stress-in-rats
#4
Hongli Sun, Rujuan Su, Xiaoxiao Zhang, Jun Wen, Dan Yao, Xinru Gao, Zhongliang Zhu, Hui Li
The molecular mechanism of individual response of susceptibility and resilience under psychological stress remains controversial and unclear. The present study aimed to explore the relationship of metabotropic glutamate receptor 5 (mGluR5) with glucocorticoid receptor (GR) or cannabinoid receptor (CB1) and further indicate the molecular mechanism of susceptibility and resilience to acute stress (AS) and chronic mild stress (CMS). Sucrose preference test and open field test were used to evaluate the response of susceptibility and resilience under stress in rats...
June 16, 2017: Neuroscience
https://www.readbyqxmd.com/read/28629384/involvement-of-the-glutamate-glutamine-cycle-and-glutamate-transporter-glt-1-in-antidepressant-like-effects-of-xiao-yao-san-on-chronically-stressed-mice
#5
Xiu-Fang Ding, Yue-Hua Li, Jia-Xu Chen, Long-Ji Sun, Hai-Yan Jiao, Xin-Xin Wang, Yan Zhou
BACKGROUND: Xiao Yao San (XYS) is an herbal prescription which is used in the treatment of depression for thousands of years from Song dynasty in China (960-1127 A.D.), and is the bestselling and most popular herb formula for treating major depression. This study aimed to assess the chronic antidepressant effects of XYS and fluoxetine in depressed mice induced by chronic unpredictable mild stress (CUMS) and its association with  alterations in glutamate/glutamine cycle and glutamate transporters...
June 19, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28628138/-effects-of-exposure-to-ambient-particulate-matter-and-polycyclic-aromatic-hydrocarbons-on-oxidative-stress-biomarkers-in-the-patients-with-chronic-obstructive-pulmonary-disease
#6
Y Zhang, X M Song, Q Zhao, T Wang, L J Li, J Chen, H B Xu, B B Liu, X Y Sun, B He, W Huang
OBJECTIVE: To investigate the effects of exposure to ambient particulate matter (PM) and polycyclic aromatic hydrocarbons (PAHs) on systemic oxidative stress biomarkers in chronic obstructive pulmonary disease (COPD) patients. METHODS: A panel of forty-five diagnosed and stable COPD patients, whose residences were within 5 kilometers from Peking University Health Science Center (PKUHSC), were recruited and followed up twice between November 2014 and May 2015. The lung function index percentage of forced expiratory volume in 1 second (FEV1) to predicted value (FEV1%pred), was measured to reflect the severity of COPD patients...
June 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28627447/pain-with-traumatic-brain-injury-and-psychological-disorders
#7
REVIEW
Samar Khoury, Rodrigo Benavides
Traumatic brain injury (TBI) is the cause for long-term disability in more than 3 million patients in the US alone, with chronic pain being the most frequently reported complain. To date, predisposing mechanisms for chronic pain in TBI patients are largely unknown. Psychological disorders, including post-traumatic stress disorder, depression and anxiety following TBI are commonly reported comorbidities to post-traumatic pain. Long term consequences can be debilitating and affect quality of life even when the injury is mild...
June 13, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28623707/the-role-of-pon-1-gr-il-18-and-oxldl-in-depression-with-and-without-posttraumatic-stress-disorder
#8
Ewa A Ogłodek
BACKGROUND: Both oxidative stress markers and inflammatory markers are important when diagnosing depression. Oxidative stress occurs due to an imbalance between free radical generation and antioxidant potential. Both adenosine triphosphate and reactive oxygen/nitrogen species are released during oxidative phosphorylation. When neuroinflammation and free radical production are increased, oxidative stress occurs and causes damage to all major cellular macromolecules. The aim of the study was to compare the concentrations of paraoxonase-1 (PON-1), glutathione reductase (GR), interleukin-18 (IL-18), and oxidized low-density lipoproteins (OxLDL) in depressed patients with and without posttraumatic stress disorder (PTSD), and PTSD alone...
March 27, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28623605/cathepsin-c-aggravates-neuroinflammation-involved-in-disturbances-of-behaviour-and-neurochemistry-in-acute-and-chronic-stress-induced-murine-model-of-depression
#9
Yanli Zhang, Kai Fan, Yanna Liu, Gang Liu, Xiaohan Yang, Jianmei Ma
Major depression has been interpreted as an inflammatory disease characterized by cell-mediated immune activation, which is generally triggered by various stresses. Microglia has been thought to be the cellular link between inflammation and depression-like behavioural alterations. The expression of cathepsin C (Cat C), a lysosomal proteinase, is predominantly induced in microglia in neuroinflammation. However, little is known about the role of Cat C in pathophysiology of depression. In the present study, Cat C transgenic mice and wild type mice were subjected to an intraperitoneal injection of LPS (0...
June 16, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28622391/neuronal-substrates-underlying-stress-resilience-and-susceptibility-in-rats
#10
Fabia Febbraro, Katrine Svenningsen, Thao Phuong Tran, Ove Wiborg
BACKGROUND: Stress and stressful life events have repeatedly been shown as causally related to depression. The Chronic Mild Stress rat model is a valid model of stress-induced depression. Like humans, rats display great heterogeneity in their response to stress and adversity. Hence some individuals are stress-sensitive and prone to develop depression-like behaviour in response to modest stressors, while others are stress-resilient and remain essentially symptom free. OBJECTIVES: Compared to the large body of research, which describes stress-induced maladaptive neurobiological changes, relatively little attention has been devoted to understand resiliency to stress...
2017: PloS One
https://www.readbyqxmd.com/read/28618657/antidepressive-effects-of-ginsenoside-rg1-via-regulation-of-hpa-and-hpg-axis
#11
Zheng Mou, Qian Huang, Shi-Feng Chu, Mei-Jin Zhang, Jin-Feng Hu, Nai-Hong Chen, Jun-Tian Zhang
BACKGROUND: Hypothalamic-pituitary-adrenal (HPA) axis hyperactivity is a well-established pathological feature of major depression, accompanied by the persistent increase of glucocorticoid level and the dysfunction of hypothalamic-pituitary-gonadal (HPG) axis. Ginsenoside Rg1 (Rg1) is one of the most active ingredients of Panax ginseng, which has various biological activity. OBJECTIVE: This study aimed to investigate the antidepressive effects of Rg1 and elucidate its impact on neuroendocrine system...
June 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28616738/living-in-a-mediterranean-city-in-2050-broadleaf-or-evergreen-citizens
#12
Lorenzo Cotrozzi, Damiano Remorini, Elisa Pellegrini, Lucia Guidi, Cristina Nali, Giacomo Lorenzini, Rossano Massai, Marco Landi
The predicted effects of global change (GC) will be exacerbated in the more densely populated cities of the future, especially in the Mediterranean basin where some environmental cues, such as drought and tropospheric ozone (O3) pollution, already mine seriously plant survival. Physiological and biochemical responses of a Mediterranean, evergreen, isohydric plant species (Quercus ilex) were compared to those of a sympatric, deciduous, anisohydric species (Q. pubescens) under severe drought (20% of the effective daily evapotranspiration) and/or chronic O3 exposure (80 ppb for 5 h day(-1) for 28 consecutive days) to test which one was more successful in those highly limiting conditions...
June 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28611606/long-term-sertraline-intake-reverses-the-behavioral-changes-induced-by-prenatal-stress-in-rats-in-a-sex-dependent-way
#13
Inês Pereira-Figueiredo, Orlando Castellano, Adelaida S Riolobos, Graça Ferreira-Dias, Dolores E López, Consuelo Sancho
Early life stress is a major factor underlying the vulnerability to respond to stressful events later in life. The present study attempted to evaluate the role of prenatal stress affecting the development of stress-related disorders and their reversion by postnatal exposure to Sertraline (SERT), a front-line medication for medication for posttraumatic stress disorder (PTSD) in humans. To achieve this, adult male and female prenatally stressed (PS) or unstressed (Controls) offspring rats, following oral chronic treatment with SERT (5 mg/kg/day; from 1 month to 4 months old), or not, were studied prior to and after a traumatic event...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28609327/fluoxetine-induces-paradoxical-effects-in-c57bl6-j-mice-comparison-with-balb-c-mice
#14
Thomas Gosselin, Anne-Marie Le Guisquet, Bruno Brizard, Caroline Hommet, Frédéric Minier, Catherine Belzung
The C57BL6/J mouse is the most commonly used strain in genetic investigations and behavioural tests. However, only a few studies have used C57BL6/J mice to assess the effects of antidepressant compounds. We carried out a study to compare the behavioural effects of fluoxetine (FLX) in a model of depression in two mice strains: C57BL6/J and BALB/c. We used an 8-week unpredictable chronic mild stress (UCMS) protocol during which FLX was administered (15 mg/kg, oral) from the third week to the end of the protocol...
June 12, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28609288/eff-ect-of-a-single-asenapine-treatment-on-fos-expression-in-the-brain-catecholamine-synthesizing-neurons-impact-of-a-chronic-mild-stress-preconditioning
#15
J Osacka, L Horvathova, Z Majercikova, Alexander Kiss
OBJECTIVE: Fos protein expression in catecholamine-synthesizing neurons of the substantia nigra (SN) pars compacta (SNC, A8), pars reticulata (SNR, A9), and pars lateralis (SNL), the ventral tegmental area (VTA, A10), the locus coeruleus (LC, A6) and subcoeruleus (sLC), the ventrolateral pons (PON-A5), the nucleus of the solitary tract (NTS-A2), the area postrema (AP), and the ventrolateral medulla (VLM-A1) was quantitatively evaluated aft er a single administration of asenapine (ASE) (designated for schizophrenia treatment) in male Wistar rats preconditioned with a chronic unpredictable variable mild stress (CMS) for 21 days...
April 25, 2017: Endocrine Regulations
https://www.readbyqxmd.com/read/28600777/psychoneuroimmunology-developments-in-stress-research
#16
REVIEW
Rainer H Straub, Maurizio Cutolo
Links between the central nervous stress system and peripheral immune cells in lymphoid organs have been detailed through 50 years of intensive research. The brain can interfere with the immune system, where chronic psychological stress inhibits many functions of the immune system. On the other hand, chronic peripheral inflammation-whether mild (during aging and psychological stress) or severe (chronic inflammatory diseases)-clearly interferes with brain function, leading to disease sequelae like fatigue but also to overt psychiatric illness...
June 9, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28595276/premorbid-iq-predicts-postconcussive-symptoms-in-oef-oif-ond-veterans-with-mtbi
#17
Jada J Stewart-Willis, Daniel Heyanka, Zoe Proctor-Weber, Heather England, Maya Bruhns
Objective: Extant literature has demonstrated that symptoms of postconcussive syndrome (PCS) persist well beyond the expected 3-month post-injury recovery period in a minority of individuals with mild traumatic brain injury (mTBI). Suboptimal performance on validity measures and pre- and post-injury psychosocial stressors - rather than actual mTBI or current cognitive functioning - have been identified as predictors of chronic PCS. Whether premorbid IQ has any influence on chronic PCS has been understudied, in the context of established psychogenic etiologies...
June 8, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28591782/sex-dependent-effects-of-stress-on-immobility-behavior-and-vta-dopamine-neuron-activity-modulation-by-ketamine
#18
Millie Rincón-Cortés, Anthony A Grace
Background: Stress constitutes a risk factor across several psychiatric disorders. Moreover, females are more susceptible to stress-related disorders, such as depression, than males. Although dopamine (DA) system underactivation is implicated in the pathophysiology of depression, little is known about the female DA system at baseline and post-stress. Methods: The effects of chronic mild stress (CMS) were examined on ventral tegmental area (VTA) DA neuron activity and forced swim test (FST) immobility by comparing male and female rats...
June 7, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28585931/the-modulation-of-adult-neuroplasticity-is-involved-in-the-mood-improving-actions-of-atypical-antipsychotics-in-an-animal-model-of-depression
#19
M Morais, P Patrício, A Mateus-Pinheiro, N D Alves, A R Machado-Santos, J S Correia, J Pereira, L Pinto, N Sousa, J M Bessa
Depression is a prevalent psychiatric disorder with an increasing impact in global public health. However, a large proportion of patients treated with currently available antidepressant drugs fail to achieve remission. Recently, antipsychotic drugs have received approval for the treatment of antidepressant-resistant forms of major depression. The modulation of adult neuroplasticity, namely hippocampal neurogenesis and neuronal remodeling, has been considered to have a key role in the therapeutic effects of antidepressants...
June 6, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28585544/serotonin-modulates-a-depression-like-state-in-drosophila-responsive-to-lithium-treatment
#20
Ariane-Saskia Ries, Tim Hermanns, Burkhard Poeck, Roland Strauss
Major depressive disorder (MDD) affects millions of patients; however, the pathophysiology is poorly understood. Rodent models have been developed using chronic mild stress or unavoidable punishment (learned helplessness) to induce features of depression, like general inactivity and anhedonia. Here we report a three-day vibration-stress protocol for Drosophila that reduces voluntary behavioural activity. As in many MDD patients, lithium-chloride treatment can suppress this depression-like state in flies. The behavioural changes correlate with reduced serotonin (5-HT) release at the mushroom body (MB) and can be relieved by feeding the antidepressant 5-hydroxy-L-tryptophan or sucrose, which results in elevated 5-HT levels in the brain...
June 6, 2017: Nature Communications
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