keyword
https://read.qxmd.com/read/37584607/antidepressant-associated-treatment-emergent-mania-a-meta-analysis-to-guide-risk-modeling-pharmacogenomic-targets-of-potential-clinical-value
#21
JOURNAL ARTICLE
Nicolas A Nuñez, Brandon J Coombes, Lindsay Melhuish Beaupre, Francisco Romo-Nava, Manuel Gardea-Resendez, Aysegul Ozerdem, Marin Veldic, Balwinder Singh, Jorge A Sanchez Ruiz, Alfredo Cuellar-Barboza, Jonathan G Leung, Miguel L Prieto, Susan L McElroy, Joanna M Biernacka, Mark A Frye
BACKGROUND: The purpose of this study was to review the association between the SLC6A4 5-HTTLPR polymorphism and antidepressant (AD)-associated treatment emergent mania (TEM) in bipolar disorder alongside starting a discussion on the merits of developing risk stratification models to guide when not to provide AD treatment for bipolar depression. METHODS: Studies that examined the association between clinical and genetic risk factors, specifically monoaminergic transporter genetic variation, and TEM were identified...
August 16, 2023: Journal of Clinical Psychopharmacology
https://read.qxmd.com/read/37558806/associations-of-the-serotonin-transporter-gene-polymorphism-5-httlpr-and-adverse-life-events-with-late-life-depression-in-the-elderly-lithuanian-population
#22
JOURNAL ARTICLE
Sandrita Simonyte, Ingrida Grabauskyte, Jurate Macijauskiene, Vita Lesauskaite, Vaiva Lesauskaite, Kari Sofie Kvaal, Robert Stewart
Late-life depression (LLD) is a multifactorial disorder, with susceptibility and vulnerability potentially influenced by gene-environment interaction. The aim of this study was to investigate whether the 5-HTTLPR polymorphism is associated with LLD. The sample of 353 participants aged 65 years and over was randomly selected from the list of Kaunas city inhabitants by Residents' Register Service of Lithuania. Depressive symptoms were ascertained using the EURO-D scale. The List of Threatening Events Questionnaire was used to identify stressful life events that happened over the last 6 months and during lifetime...
August 9, 2023: Scientific Reports
https://read.qxmd.com/read/37531334/genetic-polymorphisms-in-the-serotonin-dopamine-and-opioid-pathways-influence-social-attention-in-rhesus-macaques-macaca-mulatta
#23
JOURNAL ARTICLE
Emmeline R I Howarth, Isabelle D Szott, Claire L Witham, Craig S Wilding, Emily J Bethell
Behaviour has a significant heritable component; however, unpicking the variants of interest in the neural circuits and molecular pathways that underpin these has proven difficult. Here, we present a comprehensive analysis of the relationship between known and new candidate genes from identified pathways and key behaviours for survival in 109 adult rhesus macaques (Macaca mulatta). Eight genes involved in emotion were analysed for variation at a total of nine loci. Genetic data were then correlated with cognitive and observational measures of behaviour associated with wellbeing and survival using MCMC-based Bayesian GLMM in R, to account for relatedness within the macaque population...
2023: PloS One
https://read.qxmd.com/read/37463371/assessment-of-the-association-of-serotonin-transporter-gene-5-httvntr-5-httlpr-polymorphism-in-patients-with-fibromyalgia-syndrome
#24
JOURNAL ARTICLE
Sidrah Parvez, Ghizal Fatima, Farzana Mahdi, Najah R Hadi, Jan Fedacko
OBJECTIVE: The aim: To study the clinical and the genetic association of 5-HTTVNTR and the 5-HTTLPR polymorphisms in women with FMS. PATIENTS AND METHODS: Materials and methods: 105 FMS patients and 105 controls were enrolled in the study. Polymerase chain method was used to analyse the 5-HTTLPR & 5-HTTVNTR gene polymorphism. The psychopathology status of the 105 FMS patients and 105 healthy controls was assessed using the Beck Depression Inventory (BDI) and the Symptom Checklist-90-Revised (SCL-90-R) questionnaires...
2023: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://read.qxmd.com/read/37453823/effects-of-serotonin-transporter-and-receptor-polymorphisms-on-depression
#25
REVIEW
Yéssica P López-Echeverri, Kelly J Cardona-Londoño, Jhonny F Garcia-Aguirre, Mary Orrego-Cardozo
INTRODUCTION: Serotonin is highly implicated in the regulation of emotional state and the execution of cognitive tasks, so much so that the serotonin transporter genes (5-HTT, SLC6A4) and the serotonin receptor genes (HTR1A, HTR1B, HTR2A) have become the perfect candidates when studying the effects that these genes and their polymorphic variations have on depression characteristics. OBJECTIVE: A review of research reports that have studied the effects of variations in the serotonin transporter and receptor genes on different clinical features of depression...
July 13, 2023: Revista Colombiana de psiquiatría (English ed.)
https://read.qxmd.com/read/37441926/the-association-between-brain-serotonin-transporter-binding-and-impulsivity-and-aggression-in-healthy-individuals
#26
JOURNAL ARTICLE
Sofi da Cunha-Bang, Vibe G Frokjaer, Brenda Mc Mahon, Peter Steen Jensen, Claus Svarer, Gitte Moos Knudsen
The serotonin system plays a critical role in the modulation of impulsive aggression. Although serotonin transporters (SERT) are key in modulating synaptic serotonin levels, few studies have investigated the role of SERT levels in human impulsive aggression. The aim of this study was to investigate whether brain SERT levels are associated with trait impulsive aggression. We included 148 healthy individuals (mean age 29.3 ± 13.0, range 18-80 years, 91 females) who had undergone positron emission positron (PET) examinations with the SERT tracer [11 C]DASB and filled in self-report questionnaires of trait aggression, trait impulsivity and state aggression...
July 1, 2023: Journal of Psychiatric Research
https://read.qxmd.com/read/37404870/addressing-emotional-dysregulation-and-potential-pharmacogenetic-implication-of-5-httlpr-genotype-in-attention-deficit-hyperactivity-disorder
#27
REVIEW
Hao Xuan Tan, Adam Md Kamal, Sivakumar Thurairajasingam, Maude Elvira Phipps
BACKGROUND: This review unpacks the emotional presentation of externalizing behaviors in attention deficit hyperactivity disorder (ADHD), by diving into the psychophysiology, neurophysiology, and neurogenetics in relation to executive function. The correlations among these three variables are identified, showing that standard assessments for ADHD leave out the emotional dysregulation element. This may lead to suboptimal management outcomes during the developmental progression into adolescence and adulthood...
2023: Complex psychiatry
https://read.qxmd.com/read/37269929/the-long-and-the-short-of-it-5-httlpr-and-moral-judgement
#28
JOURNAL ARTICLE
Diana Armbruster, Klaus-Peter Lesch, Alexander Strobel
Differences in moral sentiments are widespread. Increasingly, their biological correlates are investigated to elucidate potential sources of divergent moral attitudes and choices. Serotonin is one such potential modulator. We investigated the effects of a functional serotonergic polymorphism, 5-HTTLPR, which was previously linked to moral choices albeit with inconsistent findings. N = 157 healthy young adults completed a set of congruent and incongruent moral dilemmas. In addition to the traditional moral response score, this set allows by using a process dissociation (PD) approach an estimation a deontological and a utilitarian parameter...
June 1, 2023: Behavioural Brain Research
https://read.qxmd.com/read/37233704/the-relationship-between-maternal-antibodies-to-fetal-brain-and-prenatal-stress-exposure-in-autism-spectrum-disorder
#29
JOURNAL ARTICLE
Amy N Costa, Bradley J Ferguson, Emily Hawkins, Adriana Coman, Joseph Schauer, Alex Ramirez-Celis, Patrick M Hecht, Danielle Bruce, Michael Tilley, Zohreh Talebizadeh, Judy Van de Water, David Q Beversdorf
Environmental and genetic factors contribute to the etiology of autism spectrum disorder (ASD), but their interaction is less well understood. Mothers that are genetically more stress-susceptible have been found to be at increased risk of having a child with ASD after exposure to stress during pregnancy. Additionally, the presence of maternal antibodies for the fetal brain is associated with a diagnosis of ASD in children. However, the relationship between prenatal stress exposure and maternal antibodies in the mothers of children diagnosed with ASD has not yet been addressed...
May 16, 2023: Metabolites
https://read.qxmd.com/read/37231896/altered-dna-methylation-of-the-serotonin-transporter-gene-associated-with-early-life-stress-and-white-matter-microalterations-in-korean-patients-with-panic-disorder
#30
JOURNAL ARTICLE
Hyun-Ju Kim, Minji Bang, Chun Il Park, Sang-Hyuk Lee
INTRODUCTION: Changes in the DNA methylation of 5-HTTLPR are associated with the pathophysiology of panic disorder (PD). This study was conducted to investigate the association between stressful life events and the level of 5-HTTLPR methylation in patients with PD. We also examined whether these factors were associated with white matter alterations in psychological trauma-related regions. METHODS: The participants comprised 232 patients with PD and 93 healthy adults of Korean descent...
May 25, 2023: Neuropsychobiology
https://read.qxmd.com/read/37222241/the-therapygenetics-of-anxiety-disorders
#31
JOURNAL ARTICLE
Srishti Vashishtha, Stefan Kloiber, Gwyneth Zai
Treatment of anxiety disorders primarily includes pharmacological treatment and psychotherapy, yet a substantial portion of patients do not experience sufficient clinical response. Given the significant impact of anxiety disorders on well-being and quality of life, it is pertinent to strive to ensure available treatments are of paramount efficacy. This review aimed to identify genetic variants and genes that may moderate the outcome of psychotherapy in patients with anxiety disorders, termed 'therapygenetics...
May 3, 2023: Psychiatric Genetics
https://read.qxmd.com/read/37198209/genetic-predictors-of-cultural-values-variation-between-societies
#32
JOURNAL ARTICLE
Justin Marcus, Ecesu Cetin
Associations between the STin2 and 5-HTTLPR polymorphisms within the serotonin transporter gene, SLC6A4, and culture across societies were examined. Based on an analysis of 75 primary studies (28,726 individuals), STin2 allelic frequencies were found to vary widely across countries, ranging from 26% in Germany to 85% in Singapore. Across 53 countries, and after controlling for all major environmental influences of culture, STin2 and 5-HTTLPR were found to explain 23.6% unique variance in monumentalism but none in individualism...
May 17, 2023: Scientific Reports
https://read.qxmd.com/read/37109044/association-study-of-bdnf-slc6a4-and-fto-genetic-variants-with-schizophrenia-spectrum-disorders
#33
JOURNAL ARTICLE
Aneta Bednarova, Viera Habalova, Michaela Krivosova, Matteo Marcatili, Ivan Tkac
Schizophrenia spectrum disorders (patients with a diagnosis of schizophrenia, schizotypal, and delusional disorders: F20-F29 according to International Classification of Diseases 10th revision (ICD-10)) are considered highly heritable heterogeneous psychiatric conditions. Their pathophysiology is multifactorial with involved dysregulated serotonergic neurotransmission and synaptic plasticity. The present study aimed to evaluate the association of SLC6A4 (5-HTTLPR), FTO (rs9939609), and BDNF (rs6265, rs962369) polymorphisms with schizophrenia spectrum disorders in Slovak patients...
April 12, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/36989523/meta-analysis-of-the-association-between-5-hydroxytryptamine-transporter-gene-linked-polymorphic-region-and-functional-dyspepsia-and-its-subtypes
#34
JOURNAL ARTICLE
Zhiming Wang, Liping Wu, Peiwen Dong, Qiong Wang, Xiaobin Sun, Lei Liu, Yuanbiao Guo, Yueshan Sun, Tao Shu
Background: Association studies of variations in the 5-hydroxytryptamine (5-HT, serotonin) transporter gene-linked polymorphic region (5-HTTLPR) and functional dyspepsia (FD) have yielded contradictory results. Hence, we performed a meta-analysis to clarify inconsistencies between the 5-HTTLPR polymorphism with FD and it subtypes. Methods: We performed a literature search in PubMed, Embase, Web of Science, Cochrane Library, and CNKI, including articles published until March 2022. We calculated and pooled odds ratios (ORs) with their 95% confidence intervals (CIs) in Stata 15...
March 2023: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/36983683/association-of-httlpr-bdnf-and-fto-genetic-variants-with-completed-suicide-in-slovakia
#35
JOURNAL ARTICLE
Aneta Bednarova, Viera Habalova, Silvia Farkasova Iannaccone, Ivan Tkac, Dominika Jarcuskova, Michaela Krivosova, Matteo Marcatili, Natasa Hlavacova
Since suicide and suicidal behavior are considered highly heritable phenotypes, the identification of genetic markers that can predict suicide risk is a clinically important topic. Several genes studied for possible associations between genetic polymorphisms and suicidal behaviors had mostly inconsistent and contradictory findings. The aim of this case-control study was to evaluate the associations between completed suicide and polymorphisms in genes BDNF (rs6265, rs962369), SLC6A4 ( 5-HTTLPR ), and FTO (rs9939609) in relation to sex and BMI...
March 10, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/36980311/htr1a-tph2-and-5-httlpr-polymorphisms-and-their-impact-on-the-severity-of-depressive-symptoms-and-on-the-concentration-of-tryptophan-catabolites-during-hepatitis-c-treatment-with-pegylated-interferon-%C3%AE-2a-and-oral-ribavirin-peg-ifn-%C3%AE-2a-rbv
#36
JOURNAL ARTICLE
Tomasz Pawlowski, Krzysztof Malyszczak, Dariusz Pawlak, Małgorzata Inglot, Małgorzata Zalewska, Anna Grzywacz, Marek Radkowski, Tomasz Laskus, Justyna Janocha-Litwin, Dorota Frydecka
BACKGROUND: Seeing that there are no data about associations between serotonin gene polymorphism and tryptophan catabolite concentration during PEG-IFN-α2a treatment, the aim of the current study is to examine (a) the associations between polymorphisms within the HTR1A, TPH2, and 5-HTT genes and the severity of depression symptoms and (b) the relationships among rs6295, rs4570625, and 5-HTTLPR rs25531polymorphisms and indoleamine 2,3-dioxygenase (IDO) activity, as well as kynurenine (KYN), tryptophan (TRP), kynurenic acid (KA), and anthranilic acid (AA) concentrations...
March 22, 2023: Cells
https://read.qxmd.com/read/36870383/insights-into-the-molecular-genetic-basis-of-individual-differences-in-metacognition
#37
JOURNAL ARTICLE
Mirko Lehmann, Thomas Plieger, Martin Reuter, UlrichEttinger
There is a striking lack of studies on the molecular genetic basis of metacognition, i.e., the higher-order ability to monitor mental processes. Here, an initial step toward resolving this issue was undertaken by investigating functional polymorphisms from three genes of the dopaminergic or serotonergic systems (DRD4, COMT, and 5-HTTLPR) in relation to behaviorally assessed metacognition in six paradigms across three cognitive domains. We report evidence for a task-dependent higher average confidence level (metacognitive bias) in carriers of at least one S or LG -allele in the 5-HTTLPR genotype and integrate these findings within a differential susceptibility framework...
March 2, 2023: Physiology & Behavior
https://read.qxmd.com/read/36852225/the-lack-of-influence-of-homozygous-long-allele-of-the-5-httlpr-gene-on-the-severity-of-alcohol-craving-during-6-weeks-of-rehab-hospitalisation-in-comparison-to-not-homozygous-and-homozygous-short-alleles-preliminary-report
#38
JOURNAL ARTICLE
Damian Czarnecki, Marcin Ziółkowski, Jan Chodkiewicz, Marta Gorzkiewicz, Napoleon Waszkiewicz, Anna Długosz, Jacek Budzyński, Anna Junkiert-Czarnecka, Agnieszka Kułak-Bejda
PURPOSE: The aim of this study was to assess changes in the severity of alcohol craving according to allelic variants of the 5-HTTLPR gene polymorphism during hospitalisation and their association with selected clinical variables in alcohol-dependent patients. PATIENTS AND METHODS: The study is exploratory. Participants were investigated at the 2nd and 6th week of alcohol-dependence therapy in the addiction treatment unit. Recruitment was conducted among alcohol-dependent patients from several Polish drug treatment centres...
2023: Psychology Research and Behavior Management
https://read.qxmd.com/read/36833277/comt-but-not-5httlpr-gene-is-associated-with-depression-in-first-episode-psychosis-the-role-of-stressful-life-events
#39
JOURNAL ARTICLE
Sarah Tosato, Chiara Bonetto, Katia De Santi, Antonio Lasalvia, Massimo Gennarelli, Doriana Cristofalo, Mariaelena Bertani, Mirella Ruggeri, On Behalf Of The Picos-Veneto Group
Serotonergic and dopaminergic systems are involved in the regulation of mood and reactivity to psychological stress. This study explores, in a sample of first episode psychosis (FEP) patients, whether more severe depressive symptoms were found in those who: (1) experienced a major stressful event in the 6 months preceding illness onset; and (2) were homozygous for the COMT Val158 allele or carrying the S allele of 5-HTTLPR. A total of 186 FEP patients recruited were assessed using the Hamilton Rating Scale for Depression (HAMD) for depressive symptoms...
January 29, 2023: Genes
https://read.qxmd.com/read/36747546/hypermethylation-of-the-serotonin-transporter-gene-and-paternal-parenting-styles-in-untreated-anorexia-nervosa-patients-a-pilot-study
#40
JOURNAL ARTICLE
Qianqian He, Cheng Lian, Sufang Peng, Han Chen, Qing Kang, Jue Chen
PURPOSE: It has been reported that serotonergic systems and parenting styles are involved in the pathogenesis of anorexia nervosa (AN). The present study made attempts to examine the DNA methylation profiles in the promoter region of serotonin transporter (5-HTT) encoding gene SLC6A4, and explore the association between the methylation level and severity of symptoms, 5-HTT linked polymorphic region (5-HTTLPR) genotypes and parenting styles in untreated Chinese Han AN patients. METHODS: Ninety-one untreated female AN patients (ANs) and eighty-seven matched healthy controls (HCs) were analyzed for DNA methylation status at CpG islands in the promoter region of SLC6A4 using MassARRY EpiTYPER, and genotypes of 5-HTTLPR using PCR-RFLP...
February 2023: Heliyon
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