Nicolas A Nuñez, Brandon J Coombes, Lindsay Melhuish Beaupre, Francisco Romo-Nava, Manuel Gardea-Resendez, Aysegul Ozerdem, Marin Veldic, Balwinder Singh, Jorge A Sanchez Ruiz, Alfredo Cuellar-Barboza, Jonathan G Leung, Miguel L Prieto, Susan L McElroy, Joanna M Biernacka, Mark A Frye
BACKGROUND: The purpose of this study was to review the association between the SLC6A4 5-HTTLPR polymorphism and antidepressant (AD)-associated treatment emergent mania (TEM) in bipolar disorder alongside starting a discussion on the merits of developing risk stratification models to guide when not to provide AD treatment for bipolar depression. METHODS: Studies that examined the association between clinical and genetic risk factors, specifically monoaminergic transporter genetic variation, and TEM were identified...
August 16, 2023: Journal of Clinical Psychopharmacology