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https://www.readbyqxmd.com/read/27888722/a-pilot-study-on-predictors-of-brainstem-raphe-abnormality-in-patients-with-major-depressive-disorder
#1
Milutin Kostić, Ana Munjiza, Danilo Pesic, Amir Peljto, Ivana Novakovic, Valerija Dobricic, Dusica Lecic Tosevski, Milija Mijajlovic
BACKGROUND: Hypo/anechogenicity of the brainstem raphe (BR) structures has been suggested as a possible transcranial parenchymal sonography (TCS) marker associated with depression. AIM: The aim of this study was to analyze possible association of the abnormal BR echogenicity in patients with major depression when compared to healthy controls, and to evaluate its clinical and genetic correlates. METHODS: TCS was performed in 53 patients diagnosed as major depressive disorder (MDD) without psychotic symptoms and in 54 healthy matched controls...
November 22, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27884002/depression-following-acute-coronary-syndrome-time-specific-interactions-between-stressful-life-events-social-support-deficits-and-5-httlpr
#2
Jae-Min Kim, Robert Stewart, Hee-Ju Kang, Kyung-Yeol Bae, Sung-Wan Kim, Il-Seon Shin, Young Joon Hong, Youngkeun Ahn, Myung Ho Jeong, Hyuno Kang, Jin-Sang Yoon
No abstract text is available yet for this article.
November 25, 2016: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/27880876/an-integrative-review-of-methylation-at-the-serotonin-transporter-gene-and-its-dialogue-with-environmental-risk-factors-psychopathology-and-5-httlpr
#3
REVIEW
H Palma-Gudiel, L Fañanás
Gene-environment (GxE) interactions have largely been regarded as the root of many complex disorders, including several psychiatric disorders. In this regard, it has been hypothesized that epigenetic mechanisms may be the main mediators of such interactions. Of particular interest is the previously described interaction between psychosocial stress and genetic variability of the serotonin transporter gene (SLC6A4) in its polymorphic region 5-HTTLPR. Here we review the literature concerning SLC6A4 methylation in association with environmental, clinical or genetic variables...
November 20, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27861757/extending-previous-cg%C3%A3-i-findings-on-5-httlpr-s-moderation-of-intervention-effects-on-adolescent-substance-misuse-initiation
#4
Gabriel L Schlomer, H Harrington Cleveland, Mark E Feinberg, Pedro S A Wolf, Mark T Greenberg, Richard L Spoth, Cleve Redmond, Eric P Tricou, David J Vandenbergh
This study addresses replication in candidate gene × environment interaction (cG×E) research by investigating if the key findings from Brody, Beach, Philibert, Chen, and Murry (2009) can be detected using data (N = 1,809) from the PROSPER substance use preventive intervention delivery system. Parallel to Brody et al., this study tested the hypotheses that substance misuse initiation would increase faster from age 11 to age 14 and be higher at age 14 among: (a) 5-HTTLPR short carrier adolescents versus long homozygotes, (b) control versus intervention adolescents, and (c) 5-HTTLPR short carriers in the control condition versus all other participants...
November 8, 2016: Child Development
https://www.readbyqxmd.com/read/27826101/serotonin-and-urocortin-1-in-the-dorsal-raphe-and-edinger-westphal-nuclei-after-early-life-stress-in-serotonin-transporter-knockout-rats
#5
Rick H A van der Doelen, Berit Robroch, Ilse A Arnoldussen, Maya Schulpen, Judith R Homberg, Tamás Kozicz
The interaction of early life stress (ELS) and the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) has been associated with increased risk to develop depression in later life. We have used the maternal separation paradigm as a model for ELS exposure in homozygous and heterozygous 5-HTT knockout rats and measured urocortin 1 (Ucn1) mRNA and/or protein levels, Ucn1 DNA methylation, as well as 5-HT innervation in the centrally projecting Edinger-Westphal (EWcp) and dorsal raphe (DR) nuclei, both implicated in the regulation of stress response...
November 5, 2016: Neuroscience
https://www.readbyqxmd.com/read/27819008/link-polymorphism-of-5-htt-promoter-region-is-associated-with-autoantibodies-in-patients-with-systemic-lupus-erythematosus
#6
Shu Li, Shuang Liu, Fan Chen, Yuqi Cheng, Ru Bai, Aiyun Lai, Zhaoping Lu, Jian Xu
Serotonin transporter linked polymorphic region (5-HTTLPR) was reported to associate with depression in systemic lupus erythematosus (SLE) patients by our team. To explore whether 5-HTTLPR plays a role in the pathogenesis of SLE, we tested 138 SLE patients and 138 age and sex matched health controls (HCs) for 5-HTTLPR by polymerase chain reaction (PCR) and agarose gel electrophoresis. Interestingly, the results suggest that the frequencies of SS genotype and S allele in SLE patients with positive anti-Sm antibody and anti-U1RNP antibody were both significantly higher than the other genotypes and alleles...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/27816559/interactive-effects-of-5-httlpr-genotype-and-rearing-environment-on-affective-attitude-towards-own-infant-in-japanese-mothers
#7
Erika Sawano, Hirokazu Doi, Tomoko Nagai, Satoko Ikeda, Kauyuki Shinohara
Maternal positive attitude towards one's own infant is the cornerstone of effective parenting. Previous research has revealed an influence of both genetic and environmental factors on maternal parenting behavior, but little is known of the potential gene-environment interaction in shaping a mother's affective attitude. To address this gap, we investigated the effect of a mother's childhood rearing environment and a serotonin transporter gene polymorphism (5-HTTLPR) on affective attitude towards her infant. Our analyses found an interactive effect between rearing environment and 5-HTTLPR genotype on maternal attitude...
November 2, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27798133/involvement-of-the-serotonin-transporter-gene-in-accurate-subcortical-speech-encoding
#8
Lenka Selinger, Katarzyna Zarnowiec, Marc Via, Immaculada C Clemente, Carles Escera
: A flourishing line of evidence has highlighted the encoding of speech sounds in the subcortical auditory system as being shaped by acoustic, linguistic, and musical experience and training. And while the heritability of auditory speech as well as nonspeech processing has been suggested, the genetic determinants of subcortical speech processing have not yet been uncovered. Here, we postulated that the serotonin transporter-linked polymorphic region (5-HTTLPR), a common functional polymorphism located in the promoter region of the serotonin transporter gene (SLC6A4), is implicated in speech encoding in the human subcortical auditory pathway...
October 19, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27788383/gender-specific-association-between-serotonin-transporter-polymorphisms-5-httlpr-and-rs25531-and-neuroticism-anxiety-and-depression-in-well-defined-healthy-han-chinese
#9
Chuan-Chia Chang, Hsin-An Chang, Wen-Hui Fang, Tieh-Ching Chang, San-Yuan Huang
BACKGROUND: A tri-allelic serotonin transporter promoter polymorphism (5-HTTLPR/rs25531) more effectively determines the levels of transcriptional efficacy than that with the bi-allelic 5-HTTLPR polymorphism in vitro. Both are reportedly associated with personality traits of negative emotionality, but with conflicting findings. One explanation for this is that a gender difference may play a role in genetic contribution. Here, we hypothesized that the tri-allelic genotype of the serotonin transporter is more closely linked to neuroticism, an anxiety- and depression-related trait, than the bi-allelic variation, particularly in a gender-dependent way...
October 12, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27743374/associations-between-genetic-risk-functional-brain-network-organization-and-neuroticism
#10
Michelle N Servaas, Linda Geerligs, Jojanneke A Bastiaansen, Remco J Renken, Jan-Bernard C Marsman, Ilja M Nolte, Johan Ormel, André Aleman, Harriëtte Riese
Neuroticism and genetic variation in the serotonin-transporter (SLC6A4) and catechol-O-methyltransferase (COMT) gene are risk factors for psychopathology. Alterations in the functional integration and segregation of neural circuits have recently been found in individuals scoring higher on neuroticism. The aim of the current study was to investigate how genetic risk factors impact functional network organization and whether genetic risk factors moderate the association between neuroticism and functional network organization...
October 14, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27739394/the-serotonin-transporter-promoter-polymorphism-moderates-the-continuity-of-behavioral-inhibition-in-early-childhood
#11
Victoria C Johnson, Katie R Kryski, Haroon I Sheikh, Heather J Smith, Shiva M Singh, Elizabeth P Hayden
Persistently elevated behavioral inhibition (BI) in children is a marker of vulnerability to psychopathology. However, little research has considered the joint influences of caregiver and child factors that may moderate the continuity of BI in early childhood, particularly genetic variants that may serve as markers of biological plasticity, such as the serotonin transporter linked polymorphic region (5-HTTLPR). We explored this issue in 371 preschoolers and their caregivers, examining whether parent characteristics (i...
November 2016: Development and Psychopathology
https://www.readbyqxmd.com/read/27738993/the-interaction-between-5-httlpr-and-stress-exposure-influences-connectivity-of-the-executive-control-and-default-mode-brain-networks
#12
Dennis van der Meer, Catharina A Hartman, Raimon H R Pruim, Maarten Mennes, Dirk Heslenfeld, Jaap Oosterlaan, Stephen V Faraone, Barbara Franke, Jan K Buitelaar, Pieter J Hoekstra
We recently reported that the serotonin transporter polymorphism 5-HTTLPR moderates the relation between stress exposure and attention-deficit/hyperactivity disorder (ADHD) severity. This gene-environment interaction (GxE) has been previously tied to the processing of emotional stimuli, which is increasingly recognized to be a key factor in ADHD-related impairment. The executive control and default mode brain networks play an important role in the regulation of emotion processing, and altered connectivity of these networks has also been associated with ADHD...
October 13, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27736236/harsh-parenting-and-serotonin-transporter-and-bdnf-val66met-polymorphisms-as-predictors-of-adolescent-depressive-symptoms
#13
Kalsea J Koss, E Mark Cummings, Patrick T Davies, Susan Hetzel, Dante Cicchetti
Depressive symptoms are prevalent and rise during adolescence. The present study is a prospective investigation of environmental and genetic factors that contribute to the growth in depressive symptoms and the frequency of heightened symptoms during adolescence. Participants included 206 mother-father-adolescent triads (M age at Time 1 = 13.06 years, SD = .51, 52% female). Harsh parenting was observationally assessed during a family conflict paradigm. DNA was extracted from saliva samples and genotyped for the 5-HTTLPR and BDNF Val66Met polymorphisms...
October 13, 2016: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/27701012/a-systematic-review-and-secondary-data-analysis-of-the-interactions-between-the-serotonin-transporter-5-httlpr-polymorphism-and-environmental-and-psychological-factors-in-eating-disorders
#14
REVIEW
Vanja Rozenblat, Deborah Ong, Matthew Fuller-Tyszkiewicz, Kirsti Akkermann, David Collier, Rutger C M E Engels, Fernando Fernandez-Aranda, Jaanus Harro, Judith R Homberg, Andreas Karwautz, Evelyn Kiive, Kelly L Klump, Christine L Larson, Sarah E Racine, Jodie Richardson, Howard Steiger, Scott F Stoltenberg, Tatjana van Strien, Gudrun Wagner, Janet Treasure, Isabel Krug
OBJECTIVES: To summarize and synthesize the growing gene x environment (GxE) research investigating the promoter region of the serotonin transporter gene (5-HTTLPR) in the eating disorders (ED) field, and overcome the common limitation of low sample size, by undertaking a systematic review followed by a secondary data meta-analysis of studies identified by the review. METHOD: A systematic review of articles using PsycINFO, PubMed, and EMBASE was undertaken to identify studies investigating the interaction between 5-HTTLPR and an environmental or psychological factor, with an ED-related outcome variable...
January 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27697602/sensory-processing-sensitivity-and-serotonin-gene-variance-insights-into-mechanisms-shaping-environmental-sensitivity
#15
REVIEW
Judith R Homberg, Dirk Schubert, Esther Asan, Elaine N Aron
Current research supports the notion that the apparently innate trait Sensory Processing Sensitivity (SPS) may act as a modulator of development as function of the environment. Interestingly, the common serotonin transporter linked polymorphic region (5-HTTLPR) does the same. While neural mechanisms underlying SPS are largely unknown, those associated with the 5-HTTLPR have been extensively investigated. We perform a comparative analysis of research findings on sensory processing facets associated with the trait and polymorphism to: 1...
December 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27697135/risk-impact-of-having-a-first-degree-relative-with-affective-disorder-a-7-year-follow-up-study
#16
Maj Vinberg
This study investigated a high-risk sample in order to elucidate risk factors for affective disorder. Healthy monozygotic (MZ) and dizygotic (DZ) twins with and without a co-twin with a history of affective disorder were identified through nationwide registers. Two risk groups were identified: the high-risk group comprised twins at risk of developing affective disorder (DZ or MZ twin; index co-twin affected); the low risk group (control group) comprised twins at low risk of developing affective disorder (DZ or MZ twin; index co-twin not affected)...
October 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27695066/a-novel-interaction-between-tryptophan-hydroxylase-2-tph2-gene-polymorphism-rs4570625-and-bdnf-val66met-predicts-a-high-risk-emotional-phenotype-in-healthy-subjects
#17
Maeson S Latsko, T Lee Gilman, Lindsey M Matt, K Maria Nylocks, Karin G Coifman, Aaron M Jasnow
Poor inhibitory processing of negative emotional content is central to many psychiatric disorders, including depression and anxiety. Moreover, increasing evidence suggests that core aspects of emotion-inhibitory processing are largely inherited and as such may represent a key intermediate or risk-related phenotype for common affective diseases (e.g., unipolar depressive, anxiety disorders). The current study employed a candidate-gene approach in order to most effectively examine this complex behavioral phenotype...
2016: PloS One
https://www.readbyqxmd.com/read/27681844/letter-to-the-editor-bias-in-the-measurement-of-bias-letter-regarding-citation-bias-and-selective-focus-on-positive-findings-in-the-literature-on-the-serotonin-transporter-gene-5-httlpr-life-stress-and-depression
#18
https://www.readbyqxmd.com/read/27650102/implicit-association-to-infant-faces-how-genetics-early-care-experiences-and-cultural-factors-influence-caregiving-propensities
#19
Vincenzo Paolo Senese, Kazuyuki Shinohara, Gianluca Esposito, Hirokazu Doi, Paola Venuti, Marc H Bornstein
Genetics, early experience, and culture shape caregiving, but it is still not clear how genetics, early experiences, and cultural factors might interact to influence specific caregiving propensities, such as adult responsiveness to infant cues. To address this gap, 80 Italian adults (50%M; 18-25 years) were (1) genotyped for two oxytocin receptor gene polymorphisms (rs53576 and rs2254298) and the serotonin transporter gene polymorphism (5-HTTLPR), which are implicated in parenting behaviour, (2) completed the Adult Parental Acceptance/Rejection Questionnaire to evaluate their recollections of parental behaviours toward them in childhood, and (3) were administered a Single Category Implicit Association Test to evaluate their implicit responses to faces of Italian infants, Japanese infants, and Italian adults...
September 17, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27623191/pathological-gambling-in-parkinson-s-disease-what-are-the-risk-factors-and-what-is-the-role-of-impulsivity
#20
Petra Heiden, Andreas Heinz, Nina Romanczuk-Seiferth
The incidence of pathological gambling in Parkinson's patients is significantly greater than in the general population. A correlation has been observed between dopamine agonist medication and the development of pathological gambling. However, scientists conjecture that the affected patients have underlying risk factors. Studies analysing Parkinson's patients have detected that patients who developed pathological gambling are younger, score higher on novelty-seeking tests, are more impulsive and are more likely to have a personal or family history of alcohol addiction...
September 13, 2016: European Journal of Neuroscience
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