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https://www.readbyqxmd.com/read/28616427/specific-genes-associated-with-adverse-events-of-methylphenidate-use-in-the-pediatric-population-a-systematic-literature-review
#1
REVIEW
Beinta Joensen, Morten Meyer, Lise Aagaard
The aim of this study was to review empirical studies examining associations between candidate genes and adverse events (AEs) from methylphenidate (MPH) use in children and adolescents. The PubMed, EMBASE, CINAHL, and Web of Science databases were searched from their inception until March 2017. We included empirically based articles on pharmacogenetic studies in 0-17-year-old patients that investigated associations between specific candidate genes, their polymorphisms, and reported AEs. We extracted information about study design, setting, type of AE reporter, studied genes and their polymorphisms, age and gender, administered doses, method of genotyping, outcome measures, and main findings...
April 2017: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/28592831/genetic-variation-of-dopamine-and-serotonin-function-modulates-the-feedback-related-negativity-during-altruistic-punishment
#2
Sören Enge, Hendrik Mothes, Monika Fleischhauer, Andreas Reif, Alexander Strobel
Why do humans cooperate and often punish norm violations of others? In the present study, we sought to investigate the genetic bases of altruistic punishment (AP), which refers to the costly punishment of norm violations with potential benefit for other individuals. Recent evidence suggests that norm violations and unfairness are indexed by the feedback-related negativity (FRN), an anterior cingulate cortex (ACC) generated neural response to expectancy violations. Given evidence on the role of serotonin and dopamine in AP as well as in FRN-generation, we explored the impact of genetic variation of serotonin and dopamine function on FRN and AP behavior in response to unfair vs...
June 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28590957/genetic-moderation-of-cocaine-subjective-effects-by-variation-in-the-tph1-tph2-and-slc6a4-serotonin-genes
#3
Michelle A Patriquin, Sara C Hamon, Mark J Harding, Ellen M Nielsen, Thomas F Newton, Richard De La Garza, David A Nielsen
OBJECTIVE: This study investigated variants of tryptophan hydroxylase (TPH)1, TPH2, and SLC6A4 in the moderation of the subjective effects of cocaine. METHODS: Non-treatment-seeking cocaine-dependent individuals (N=66) were intravenously administered saline and cocaine (40 mg) in a randomized order. Participants self-reported subjective effects of cocaine using a visual analog scale starting before administration of saline or cocaine (-15 min) to up to 20 min after infusion...
June 6, 2017: Psychiatric Genetics
https://www.readbyqxmd.com/read/28590587/genetic-variants-in-5-httlpr-bdnf-htr1a-comt-and-fkbp5-and-risk-for-treated-depression-after-cancer-diagnosis
#4
Nis P Suppli, Jens D Bukh, Terrie E Moffitt, Avshalom Caspi, Christoffer Johansen, Anne Tjønneland, Lars V Kessing, Susanne O Dalton
BACKGROUND: The role of gene-environment interactions in the pathogenesis of depression is unclear. Previous studies addressed vulnerability for depression after childhood adversity and stressful life events among carriers of numerous specific genetic variants; however, the importance of individual genetic variants, the environmental exposures with which they interact, and the magnitude of the risk conveyed by these interactions remain elusive. METHODS: We included 7,320 people with a first primary cancer identified in the prospective Diet, Cancer and Health study in an exposed-only cohort study...
June 7, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28589968/the-5-httlpr-polymorphism-affects-network-based-functional-connectivity-in-the-visual-limbic-system-in-healthy-adults
#5
Hengyi Cao, Anais Harneit, Henrik Walter, Susanne Erk, Urs Braun, Carolin Moessnang, Lena S Geiger, Zhenxiang Zang, Sebastian Mohnke, Andreas Heinz, Nina Romanczuk-Seiferth, Thomas Mühleisen, Manuel Mattheisen, Stephanie H Witt, Sven Cichon, Markus M Nöthen, Marcella Rietschel, Andreas Meyer-Lindenberg, Heike Tost
The serotonin transporter linked polymorphic region 5-HTTLPR is a key genetic regulator of 5-HTT expression in the human brain where the short allele S has been implicated in emotion dysregulation. However, the neural mechanism underlying the association between this variant and emotion processing is still unclear. Earlier studies suggested an effect of 5-HTTLPR on amygdala activation during emotional face processing. However, this association has been questioned in recent studies employing larger sample sizes and meta-analyses...
June 7, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28585929/association-between-the-serotonin-transporter-gene-polymorphism-and-verbal-learning-in-older-adults-is-moderated-by-gender
#6
A-R Imlach, D D Ward, J C Vickers, M J Summers, K L Felmingham
The S allele of the functional 5-HTTLPR polymorphism has previously been associated with reductions in memory function. Given the change in function of the serotonergic system in older adults, and the functional consequences of memory decline in this age group, further investigation into the impact of 5-HTTLPR in healthy older adults is required. This investigation examined the effect of 5-HTTLPR variants (S carriers versus L/L homozygotes) on verbal and visual episodic memory in 438 healthy older adults participating in the Tasmanian Healthy Brain Project (age range 50-79 years, M=60...
June 6, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28581303/interplay-between-children-s-biobehavioral-plasticity-and-interparental-relationship-in-the-origins-of-internalizing-problems
#7
Rebecca L Brock, Grazyna Kochanska, Lea J Boldt
The present study demonstrates the interplay between interparental relationship satisfaction and child plasticity in the origins of internalizing problems in 99 community mothers, fathers, and children. Our cumulative measure of plasticity integrated genetics (5-HTTLPR polymorphism), psychophysiology (skin conductance level), and observed behavior (inhibition, sadness, joy). The interaction between plasticity and interparental relationship satisfaction reflected differential susceptibility. Compared with low-plasticity peers, high-plasticity children had more internalizing problems from 5...
June 5, 2017: Journal of Family Psychology: JFP
https://www.readbyqxmd.com/read/28580622/heightened-amygdala-responsiveness-in-s-carriers-of-5-httlpr-genetic-polymorphism-reflects-enhanced-cortical-rather-than-subcortical-inputs-an-meg-study
#8
Qian Luo, Tom Holroyd, Derek Mitchell, Henry Yu, Xi Cheng, Colin Hodgkinson, Gang Chen, Daniel McCaffrey, David Goldman, R James Blair
Short allele carriers (S-carriers) of the serotonin transporter gene (5-HTTLPR) show an elevated amygdala response to emotional stimuli relative to long allele carriers (LL-homozygous). However, whether this reflects increased responsiveness of the amygdala generally or interactions between the amygdala and the specific input systems remains unknown. It is argued that the amygdala receives input via a quick subcortical and a slower cortical pathway. If the elevated amygdala response in S-carriers reflects generally increased amygdala responding, then group differences in amygdala should be seen across the amygdala response time course...
June 5, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28576508/a-review-of-the-role-of-serotonin-system-genes-in-obsessive-compulsive-disorder
#9
REVIEW
Vanessa Sinopoli, Christie L Burton, Sefi Kronenberg, Paul D Arnold
SINOPOLI, V., C.L. Burton, S. Kronenberg and P.D. Arnold. A review of the role of serotonin system genes in obsessive-compulsive disorder. NEUROSCI BIOBEHAV REV X(X) XXX-XXX, 2017.- Obsessive-compulsive disorder (OCD) is a debilitating neuropsychiatric disorder that causes the patient to experience intrusive thoughts and/or to carry out repetitive, ritualized behaviors that are time consuming and impairing. OCD is familial and heritable. The genetic factors responsible for pathogenesis, however, remain largely unknown despite the numerous candidate gene studies conducted...
May 30, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28569537/variation-in-the-serotonin-transporter-polymorphism-5-httlpr-and-inertia-of-negative-and-positive-emotions-in-daily-life
#10
Eeske van Roekel, Maaike Verhagen, Rutger C M E Engels, Peter Kuppens
An important element of understanding the genotype-phenotype link in psychiatric disorders lies in identifying the psychological mechanisms through which genetic variation impacts mental health. Here we examined whether emotional inertia, the tendency for a person's emotions to carry over from 1 moment to the next and a prospective predictor of the development of depression, is associated with a known genetic risk factor for emotional dysregulation, a polymorphism in the serotonin transporter gene (5-HTTLPR)...
June 1, 2017: Emotion
https://www.readbyqxmd.com/read/28534451/genetic-moderation-of-multiple-pathways-linking-early-cumulative-socioeconomic-adversity-and-young-adults-cardiometabolic-disease-risk
#11
Kandauda A S Wickrama, Tae Kyoung Lee, Catherine Walker O'Neal
Recent research suggests that psychosocial resources and life stressors are mediating pathways explaining socioeconomic variation in young adults' health risks. However, less research has examined both these pathways simultaneously and their genetic moderation. A nationally representative sample of 11,030 respondents with prospective data collected over 13 years from the National Study of Adolescent to Adult Health was examined. First, the association between early cumulative socioeconomic adversity and young adults' (ages 25-34) cardiometabolic disease risk, as measured by 10 biomarkers, through psychosocial resources (educational attainment) and life stressors (accelerated transition to adulthood) was examined...
May 23, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28533695/the-triallelic-serotonin-transporter-gene-polymorphism-is-associated-with-depressive-symptoms-in-adults-with-chronic-pain
#12
W Michael Hooten, Cynthia O Townsend, Christopher D Sletten
BACKGROUND: The serotonin (5-HT) transporter-linked polymorphic region (5-HTTLPR) moderates the relationship between stressful life events and depression. Given the high prevalence of depression in chronic pain, the primary aim of this preliminary study was to investigate the associations between the 5-HTTLPR and the severity of depressive symptoms in a cohort of adults with chronic pain. METHODS: Adults with chronic pain who were consecutively admitted to an outpatient pain rehabilitation program and met inclusion criteria were recruited for study participation (n=277)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28491024/the-serotonin-transporter-and-early-life-stress-translational-perspectives
#13
REVIEW
Danielle J Houwing, Bauke Buwalda, Eddy A van der Zee, Sietse F de Boer, Jocelien D A Olivier
The interaction between the serotonin transporter (SERT) linked polymorphic region (5-HTTLPR) and adverse early life stressing (ELS) events is associated with enhanced stress susceptibility and risk to develop mental disorders like major depression, anxiety, and aggressiveness. In particular, human short allele carriers are at increased risk. This 5-HTTLPR polymorphism is absent in the rodent SERT gene, but heterozygous SERT knockout rodents (SERT(+/-)) show several similarities to the human S-allele carrier, therefore creating an animal model of the human situation...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28467954/-association-between-the-5-httlpr-polymorphism-of-the-serotonin-transporter-gene-and-suicide-a-case-control-pilot-study
#14
Janos Bokor, Xenia Gonda, Peter Dome, Gabor Faludi, Elek Dinya, Andras Laszik
OBJECTIVES: Besides psychological and social effects, biological, biochemical and genetic factors also play a role in the background of suicide. The aim is developing a complex model incorporating all the above factors so that suicide could be predicted and prevented in those at risk. Based on several studies 5-HTTLPR s allele frequency is increased in case of violent completed suicides. The aim of the present study was to validate this association in a sample of completed suicides. METHODS: During autopsy sample DNA samples were obtained for 5-HTTLPR genotyping from 200 subjects deceased due to suicide and 200 controls deceased due to other causes...
March 2017: Neuropsychopharmacologia Hungarica
https://www.readbyqxmd.com/read/28444137/effects-of-serotonin-transporter-gene-variation-on-impulsivity-mediated-by-default-mode-network-a-family-study-of-depression
#15
Jiook Cha, Guia Guffanti, Jay Gingrich, Ardesheer Talati, Priya Wickramaratne, Myrna Weissman, Jonathan Posner
Serotonergic neurotransmission, potentially through effects on the brain's default mode network (DMN), may regulate aspects of attention including impulse control. Indeed, genetic variants of the serotonin transporter (5-HTT) have been implicated in impulsivity and related psychopathology. Yet it remains unclear the mechanism by which the 5-HTT genetic variants contribute to individual variability in impulse control. Here, we tested whether DMN connectivity mediates an association between the 5-HTT genetic variants and impulsivity...
April 21, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28434415/does-the-incredible-years-reduce-child-externalizing-problems-through-improved-parenting-the-role-of-child-negative-affectivity-and-serotonin-transporter-linked-polymorphic-region-5-httlpr-genotype
#16
Joyce Weeland, Rabia R Chhangur, Sara R Jaffee, Danielle Van Der Giessen, Walter Matthys, Bram Orobio De Castro, Geertjan Overbeek
In a randomized controlled trial, the Observational Randomized Controlled Trial of Childhood Differential Susceptibility (ORCHIDS study), we tested whether observed parental affect and observed and reported parenting behavior are mechanisms of change underlying the effects of the behavioral parent training program the Incredible Years (IY). Furthermore, we tested whether some children are more susceptible to these change mechanisms because of their temperamental negative affectivity and/or serotonin transporter linked polymorphic region (5-HTTLPR) genotype...
April 24, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28416295/depressive-symptoms-in-schizophrenia-and-dopamine-and-serotonin-gene-polymorphisms
#17
Vjekoslav Peitl, Mario Štefanović, Dalibor Karlović
Although depressive symptoms seem to be frequent in schizophrenia they have received significantly less attention than other symptom domains. As impaired serotonergic and dopaminergic neurotransmission is implicated in the pathogenesis of depression and schizophrenia this study sought to investigate the putative association between several functional gene polymorphisms (SERT 5-HTTLPR, MAO-A VNTR, COMT Val158Met and DAT VNTR) and schizophrenia. Other objectives of this study were to closely examine schizophrenia symptom domains by performing factor analysis of the two most used instruments in this setting (Positive and negative syndrome scale - PANSS and Calgary depression rating scale - CDSS) and to examine the influence of investigated gene polymorphisms on the schizophrenia symptom domains, focusing on depressive scores...
April 14, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28414511/change-in-attachment-predicts-change-in-emotion-regulation-particularly-among-5-httlpr-short-allele-homozygotes
#18
Kristine Rensvik Viddal, Turid Suzanne Berg-Nielsen, Jay Belsky, Lars Wichstrøm
In view of the theory that the attachment relationship provides a foundation for the development of emotion regulation, here, we evaluated (a) whether change in attachment security from 4 to 6 years predicts change in emotion regulation from 6 to 8 years and (b) whether 5-HTTLPR moderates this relation in a Norwegian community sample (n = 678, 99.7% Caucasian). Attachment was measured with the Manchester Child Attachment Story Task, and teachers completed the Emotion Regulation Checklist. Attachment security was modestly stable, with children becoming more secure over time...
April 17, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28391138/associations-between-serotonin-transporter-and-behavioral-traits-and-diagnoses-related-to-anxiety
#19
Ardesheer Talati, Zagaa Odgerel, Priya J Wickramaratne, Andrea Norcini-Pala, Jamie L Skipper, Jay A Gingrich, Myrna M Weissman
The role of the serotonin transporter promoter-linked polymorphism (5-HTTLPR) in psychiatric disease remains unclear. Behavioral traits could serve as alternative outcomes that are stable, precede psychopathology, and capture more sub-clinical variation. We test associations between 5-HTTLPR and (1) behavioral traits and (2) clinical diagnoses of anxiety and depression. Second and third generation participants (N=203, 34.2±13.8 years, 54% female) at high- or low- familial risk for depression (where risk was defined by the presence of major depression in the 1st generation) were assessed longitudinally using the Schedule for Affective Disorders and Schizophrenia-lifetime interview, Barratt Impulsiveness Scale-11, Buss-Perry Aggression Questionnaire, and the NEO-Five Factor Inventory...
July 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28377990/the-effect-of-an-adverse-psychological-environment-on-salivary-cortisol-levels-in-the-elderly-differs-by-5-httlpr-genotype
#20
Marie-Laure Ancelin, Jacqueline Scali, Joanna Norton, Karen Ritchie, Anne-Marie Dupuy, Isabelle Chaudieu, Joanne Ryan
BACKGROUND: An adverse psychological environment (e.g. stressful events or depression) has been shown to influence basal cortisol levels and cortisol response to stress. This differs depending on the adverse stimuli, but also varies across individuals and may be influenced by genetic predisposition. An insertion/deletion polymorphism in the serotonin transporter gene (5-HTTLPR) is a strong candidate in this regard. OBJECTIVE: To investigate how stressful life events and depression are associated with diurnal cortisol levels in community-dwelling elderly and determine whether this varies according to genetic variability in the 5-HTTLPR...
December 2017: Neurobiology of Stress
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