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https://www.readbyqxmd.com/read/29778546/imaging-genetics-paradigms-in-depression-research-systematic-review-and-meta-analysis
#1
REVIEW
Lícia P Pereira, Cristiano A Köhler, Brendon Stubbs, Kamilla W Miskowiak, Gerwyn Morris, Bárbara P de Freitas, Trevor Thompson, Brisa S Fernandes, André R Brunoni, Michael Maes, Diego A Pizzagalli, André F Carvalho
Imaging genetics studies involving participants with major depressive disorder (MDD) have expanded. Nevertheless, findings have been inconsistent. Thus, we conducted a systematic review and meta-analysis of imaging genetics studies that enrolled MDD participants across major databases through June 30th, 2017. Sixty-five studies met eligibility criteria (N = 4034 MDD participants and 3293 controls), and there was substantial between-study variability in the methodological quality of included studies. However, few replicated findings emerged from this literature with only 22 studies providing data for meta-analyses (882 participants with MDD and 616 controls)...
May 17, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29760654/failure-to-replicate-the-association-between-fractional-anisotropy-and-the-serotonin-transporter-gene-5-httlpr-rs25531
#2
Tim Klucken, Isabell Tapia León, Carlo Blecker, Onno Kruse, Tobias Stalder, Rudolf Stark
Recent work underlines the importance of alterations in white matter (e.g., measured by fractional anisotropy (FA)) as a neural vulnerability marker for psychiatric disorders. In this context, the uncinate fasciculus (UF), which connects the limbic system with prefrontal areas, has repeatedly been linked to psychiatric disorders, fear processing, and anxiety-related traits. Individual differences in FA may partly be genetically determined. Variation in the promoter region of the serotonin transporter gene (serotonin transporter-linked polymorphic region [5-HTTLPR]) is a particularly promising candidate in this context, which has been linked to psychiatric disorders as well as to limbic and prefrontal reactivity...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29730700/risk-seeking-for-losses-is-associated-with-5-httlpr-but-not-with-transient-changes-in-5-ht-levels
#3
Philipp T Neukam, Nils B Kroemer, Yacila I Deza Araujo, Lydia Hellrung, Shakoor Pooseh, Marcella Rietschel, Stephanie H Witt, Uwe Schwarzenbolz, Thomas Henle, Michael N Smolka
RATIONALE: Serotonin (5-HT) plays a key role in different aspects of value-based decision-making. A recent framework proposed that tonic 5-HT (together with dopamine, DA) codes future average reward expectations, providing a baseline against which possible choice outcomes are compared to guide decision-making. OBJECTIVES: To test whether high 5-HT levels decrease loss aversion, risk-seeking for gains, and risk-seeking for losses. METHODS: In a first session, 611 participants were genotyped for 5-HTTLPR and performed a mixed gambles (MGA) task and two probability discounting tasks for gains and losses, respectively (PDG/PDL)...
May 5, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29712944/appetitive-and-reactive-aggression-are-differentially-associated-with-the-stin2-genetic-variant-in-the-serotonin-transporter-gene
#4
Sian Megan Joanna Hemmings, Khethelo Xulu, Jessica Sommer, Martina Hinsberger, Stefanie Malan-Muller, Gerard Tromp, Thomas Elbert, Roland Weierstall, Soraya Seedat
Appetitive aggression is a sub-category of instrumental aggression, characterised by the primary intrinsic enjoyment of aggressive activity. Aggression is heritable, and serotonergic and monoaminergic neurotransmitter systems have been found to contribute to the underlying molecular mechanisms. The aim of this study was to investigate the role that genetic variants in the serotonin transporter (SLC6A4) and monoamine oxidase A (MAOA) genes play in the aetiology of appetitive aggression in South African Xhosa males (n = 290)...
April 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29683385/polymorphism-in-the-serotonin-transporter-gene-polymorphisms-5-httlpr-modifies-the-association-between-significant-life-events-and-depression-in-people-with-multiple-sclerosis
#5
Alice Saul, Bruce Taylor, Steve Simpson, Anne-Louise Ponsonby, Leigh Blizzard, Terence Dwyer, Brendan McMorran, Brenda Wood, Ingrid Af van der Mei
BACKGROUND: In the general population, variation in the serotonin-transporter-linked polymorphic region ( 5-HTTLPR) has been shown to modify the association between stressful events and depression/anxiety. This has not been examined in people with multiple sclerosis (MS). OBJECTIVE: We examined the interaction between significant life events (SLE), 5-HTTLPR and depression/anxiety. METHODS: A population-based longitudinal cohort of 198 people with MS was followed biannually for 2...
April 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29673739/association-of-serotonin-and-gaba-pathway-gene-polymorphisms-with-alcohol-dependence-a-preliminary-study
#6
Shweta Sahni, Mayanka Tickoo, Ranjan Gupta, Meera Vaswani, Atul Ambekar, Tripti Grover, Arundhati Sharma
BACKGROUND: Alcohol dependence (AD), characterized by profound disruptions in specific circuits of the brain is influenced by both environmental, which play a significant role in developing addiction and genetic factors, which make some individuals more susceptible to disruptions. Various polymorphisms in the neurotransmitter genes are reported to increase the risk of developing dependence. The present study aimed to identify association of serotonin and GABA polymorphisms with AD in Indian subjects...
April 9, 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29661255/serotonergic-gene-polymorphisms-5-httlpr-5htr1a-5htr2a-and-population-differences-in-aggression-traditional-hadza-and-datoga-and-industrial-russians-populations-compared
#7
Marina L Butovskaya, Polina R Butovskaya, Vasiliy A Vasilyev, Jane M Sukhodolskaya, Dania I Fekhredtinova, Dmitri V Karelin, Julia N Fedenok, Audax Z P Mabulla, Alexey P Ryskov, Oleg E Lazebny
BACKGROUND: Current knowledge on genetic basis of aggressive behavior is still contradictory. This may be due to the fact that the majority of studies targeting associations between candidate genes and aggression are conducted on industrial societies and mainly dealing with various types of psychopathology and disorders. Because of that, our study was carried on healthy adult individuals of both sex (n = 853). METHODS: Three populations were examined: two traditional (Hadza and Datoga) and one industrial (Russians), and the association of aggression with the following polymorphisms 5-HTTLPR, rs6295 (5HTR1A gene), and rs6311 (5HTR2A gene) were tested...
April 16, 2018: Journal of Physiological Anthropology
https://www.readbyqxmd.com/read/29628626/gene-environment-correlations-in-the-cross-generational-transmission-of-parenting-grandparenting-moderates-the-effect-of-child-5-httlpr-genotype-on-mothers-parenting
#8
Daniel C Kopala-Sibley, Elizabeth P Hayden, Shiva M Singh, Haroon I Sheikh, Katie R Kryski, Daniel N Klein
Evidence suggests that parenting is associated cross-generationally and that children's genes may elicit specific parenting styles (evocative gene-environment correlation). This study examined whether the effect of children's genotype, specifically 5-HTTLPR, on mothers' parenting behaviors was moderated by her own parenting experiences from her mother. Two independent samples of three-year-olds (N = 476 and 405) were genotyped for the serotonin transporter gene, and observational measures of parenting were collected...
November 2017: Social Development
https://www.readbyqxmd.com/read/29547643/automatic-approach-avoidance-tendencies-as-a-candidate-intermediate-phenotype-for-depression-associations-with-childhood-trauma-and-the-5-httlpr-transporter-polymorphism
#9
Pascal Fleurkens, Agnes van Minnen, Eni S Becker, Iris van Oostrom, Anne Speckens, Mike Rinck, Janna N Vrijsen
Depression risk genes in combination with childhood events have been associated with biased processing as an intermediate phenotype for depression. The aim of the present conceptual replication study was to investigate the role of biased automatic approach-avoidance tendencies as a candidate intermediate phenotype for depression, in the context of genes (5-HTTLPR polymorphism) and childhood trauma. A naturalistic remitted depressed patients sample (N = 209) performed an Approach-Avoidance Task (AAT) with facial expressions (angry, sad, happy and neutral)...
2018: PloS One
https://www.readbyqxmd.com/read/29535036/interactive-effects-of-genetic-polymorphisms-and-childhood-adversity-on-brain-morphologic-changes-in-depression
#10
REVIEW
Yong-Ku Kim, Byung-Joo Ham, Kyu-Man Han
The etiology of depression is characterized by the interplay of genetic and environmental factors and brain structural alteration. Childhood adversity is a major contributing factor in the development of depression. Interactions between childhood adversity and candidate genes for depression could affect brain morphology via the modulation of neurotrophic factors, serotonergic neurotransmission, or the hypothalamus-pituitary-adrenal (HPA) axis, and this pathway may explain the subsequent onset of depression...
March 10, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29462807/the-return-of-fear-variation-of-the-serotonin-transporter-gene-predicts-outcome-of-a-highly-standardized-exposure-based-one-session-fear-treatment
#11
André Wannemüller, Dirk Moser, Robert Kumsta, Hans-Peter Jöhren, Jürgen Margraf
BACKGROUND: Methodological problems of existing research, such as the application of unstandardized treatments in heterogeneous samples, has hampered clear conclusions about the extent and direction to which allelic variation of the serotonin transporter gene-linked polymorphic region (5- HTTLPR) is associated with a differential response to psychological treatment. The present study aimed to investigate the effects of the 5-HTTLPR genotype on treatment outcome under highly standardized environmental conditions...
2018: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/29441949/effect-of-serotonin-transporter-genotype-on-self-reported-efficacy-and-activity-changes-of-brain-prefrontal-area-in-response-to-placebo
#12
M Isawa, R Tashiro, C Naruse, Y Yamaguchi, H Itoh, T Nishimura, M Tomi, H Shimada, H Saito, M Mochizuki, E Nakashima
Patients benefit from drug therapy not only through pharmacological mechanisms, but also through non-pharmacological action (placebo effect), which may be mediated in part by the prefrontal area of the brain. We consider that the difference between responders and non-responders to placebo might be related to polymorphisms in the serotonin transporter-linked polymorphic region (5-HTTLPR). To study this idea, we performed a randomized double-blind clinical trial using caffeine and lactose (placebo). Activity in the prefrontal area of the brain was measured in terms of blood flow by means of near-infrared spectroscopy (NIRS) as an objective indicator...
January 2, 2018: Die Pharmazie
https://www.readbyqxmd.com/read/29434543/altered-functional-connectivity-of-fronto-cingulo-striatal-circuits-during-error-monitoring-in-adolescents-with-a-history-of-childhood-abuse
#13
Heledd Hart, Lena Lim, Mitul A Mehta, Charles Curtis, Xiaohui Xu, Gerome Breen, Andrew Simmons, Kah Mirza, Katya Rubia
Childhood maltreatment is associated with error hypersensitivity. We examined the effect of childhood abuse and abuse-by-gene ( 5-HTTLPR, MAOA ) interaction on functional brain connectivity during error processing in medication/drug-free adolescents. Functional connectivity was compared, using generalized psychophysiological interaction (gPPI) analysis of functional magnetic resonance imaging (fMRI) data, between 22 age- and gender-matched medication-naïve and substance abuse-free adolescents exposed to severe childhood abuse and 27 healthy controls, while they performed an individually adjusted tracking stop-signal task, designed to elicit 50% inhibition failures...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29427306/impaired-fear-extinction-in-serotonin-transporter-knockout-rats-is-associated-with-increased-5-hydroxymethylcytosine-in-the-amygdala
#14
Ling Shan, Hang-Yuan Guo, Corina N A M van den Heuvel, Joop van Heerikhuize, Judith R Homberg
AIMS: One potential risk factor for posttraumatic stress disorder (PTSD) involves the low activity (short; s) allelic variant of the serotonin transporter-linked polymorphic region (5-HTTLPR), possibly due to reduced prefrontal control over the amygdala. Evidence shows that DNA methylation/demethylation is crucial for fear extinction in these brain areas and is associated with neuronal activation marker c-Fos expression. We hypothesized that impaired fear extinction in serotonin transporter knockout (5-HTT-/- ) rats is related to changes in DNA (de) methylation and c-Fos expression in the prefrontal cortex (PFC) and/or amygdala...
February 9, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29414128/the-effects-of-5-httlpr-and-bdnf-val66met-polymorphisms-on-neurostructural-changes-in-major-depressive-disorder
#15
Kyu-Man Han, Sunyoung Choi, Aram Kim, June Kang, Eunsoo Won, Woo-Suk Tae, Yong-Ku Kim, Min-Soo Lee, Byung-Joo Ham
The serotonin-transporter-linked polymorphic region (5-HTTLPR) and brain-derived neurotrophic factor (BDNF) Val66Met polymorphism have been implicated in the pathophysiology of major depressive disorder (MDD). We aimed to investigate the effects of genetic variants of the 5-HTTLPR and BDNF Val66Met polymorphisms and their interactions with MDD on cortical volume and white matter integrity. Ninety-five patients with MDD and 65 healthy participants aged 20-65 years were recruited. The subjects were genotyped for the 5-HTTLPR and BDNF Val66Met polymorphisms and scanned with T1-weighted and diffusion tensor imaging...
March 30, 2018: Psychiatry research. Neuroimaging
https://www.readbyqxmd.com/read/29411704/-genetic-association-analyses-of-the-endocannabinoid-system-on-anxious-phenotype
#16
Judit Lazary, Nora Eszlari, Gabriella Juhasz, Gyorgy Bagdy
BACKGROUND: Accumulating data confirmed that the endocannabinoid system (ECS) is involved in the regulation of stress response and emotional processes, therefore ECS became an important pharmacological target as a potential anxiolytic. Although unequivocal data from animal studies confirmed the relevancy of the ECS in anxious phenotype, human genetic data are poorly available in the literature in this field. In the presented studies we tested possible associations between anxious phenotype and the cannabinoid receptor 1 and the fatty acid amide hydrolase gene polymorphisms...
December 2017: Neuropsychopharmacologia Hungarica
https://www.readbyqxmd.com/read/29407665/risky-driving-and-the-persistent-effect-of-a-randomized-intervention-focusing-on-impulsivity-the-role-of-the-serotonin-transporter-promoter-polymorphism
#17
Diva Eensoo, Marika Paaver, Mariliis Vaht, Helle-Mai Loit, Jaanus Harro
Road traffic accidents are a serious public health issue, and real-life traffic offences are an excellent indicator of the behavioural tendencies of impulsivity and risk-taking. We have previously reported on short-term efficacy of a brief intervention in driving schools to reduce traffic risks (Paaver et al., Accid. Anal. Prev., 2013; 50, 430-437), and have now addressed the question of whether does the impact of the intervention last for a few years, and whether traffic behaviour and the intervention effect are associated with the serotonin transporter polymorphism (5-HTTLPR) genotype as the central serotonin system is strongly associated with impulse control...
April 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29387527/high-brain-serotonin-levels-in-migraine-between-attacks-a-5-ht-4-receptor-binding-pet-study
#18
Marie Deen, Hanne D Hansen, Anders Hougaard, Martin Nørgaard, Hans Eiberg, Szabolcs Lehel, Messoud Ashina, Gitte M Knudsen
Migraine has been hypothesized to be a syndrome of chronic low serotonin (5-HT) levels, but investigations of brain 5-HT levels have given equivocal results. Here, we used positron emission tomography (PET) imaging of the 5-HT4 receptor as a proxy for brain 5-HT levels. Given that the 5-HT4 receptor is inversely related to brain 5-HT levels, we hypothesized that between attacks migraine patients would have higher 5-HT4 receptor binding compared to controls. Eighteen migraine patients without aura (migraine free >48 h), and 16 age- and sex-matched controls underwent PET scans after injection of [11 C]SB207145, a specific 5-HT4 receptor radioligand...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29368666/tryptophan-supplementation-and-serotonin-function-genetic-variations-in-behavioural-effects
#19
E L Gibson
The neurotransmitter serotonin has a role in affective disorders such as depression and anxiety, as well as sleep, cognitive function and appetite. This review examines the evidence that serotonin-related genotypes may moderate the behavioural effects of supplementation with the serotonin precursor amino acid l-tryptophan (TRP), on which synthesis of serotonin (or 5-hydroxytryptamine; 5-HT) depends. However, 95 % of serotonin is synthesised and used in the periphery, and TRP is also metabolised via non-5-HT routes such as the kynurenine pathway...
January 25, 2018: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/29358097/the-effect-of-5-httlpr-and-a-serotonergic-multi-marker-score-on-amygdala-prefrontal-and-anterior-cingulate-cortex-reactivity-and-habituation-in-a-large-healthy-fmri-cohort
#20
J H Piel, T A Lett, C Wackerhagen, M M Plichta, S Mohnke, O Grimm, N Romanczuk-Seiferth, F Degenhardt, H Tost, S Witt, M Nöthen, M Rietschel, A Heinz, A Meyer-Lindenberg, H Walter, S Erk
Major depressive disorder (MDD) is characterized by low mood for at least two weeks. Impaired emotion regulation has been suggested to be the consequence of dysfunctional serotonergic regulation of limbic and prefrontal regions, especially the amygdala, the anterior cingulate cortex (ACC) and the prefrontal cortex (PFC). The impact of genetic variation on brain function can be investigated with intermediate phenotypes. A suggested intermediate phenotype of MDD is emotion recognition: The 5-HTTLPR polymorphism of SLC6A4 as well as other serotonergic genes have been associated with amygdala and prefrontal function during emotion recognition...
March 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
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