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https://www.readbyqxmd.com/read/29163018/brain-networks-implicated-in-seasonal-affective-disorder-a-neuroimaging-pet-study-of-the-serotonin-transporter
#1
Martin Nørgaard, Melanie Ganz, Claus Svarer, Patrick M Fisher, Nathan W Churchill, Vincent Beliveau, Cheryl Grady, Stephen C Strother, Gitte M Knudsen
Background: Seasonal Affective Disorder (SAD) is a subtype of Major Depressive Disorder characterized by seasonally occurring depression that often presents with atypical vegetative symptoms such as hypersomnia and carbohydrate craving. It has recently been shown that unlike healthy people, patients with SAD fail to globally downregulate their cerebral serotonin transporter (5-HTT) in winter, and that this effect seemed to be particularly pronounced in female S-carriers of the 5-HTTLPR genotype. The purpose of this study was to identify a 5-HTT brain network that accounts for the adaption to the environmental stressor of winter in females with the short 5-HTTLPR genotype, a specific subgroup previously reported to be at increased risk for developing SAD...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29155230/the-association-of-monoamine-related-gene-polymorphisms-with-behavioural-correlates-of-response-inhibition-a-meta-analytic-review
#2
REVIEW
Irene Rincón-Pérez, Alberto J Sánchez-Carmona, Jacobo Albert, José A Hinojosa
Response inhibition has been shown to be associated with monoamine-related gene polymorphisms, although evidence is inconclusive. To comprehensively examine these genotype effects on behavioural correlates of response inhibition in non-clinical adult populations, we performed a two-step approach. A systematic review of studies using Go/No-Go and/or Stop-Signal paradigms was first carried out. Thirty-eight eligible research articles were identified, which examined over 15 candidate genes. Remarkably, no firm conclusions could be drawn from these studies...
November 16, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29129791/resting-state-networks-mediate-the-effect-of-genotype-by-environment-interaction-on-mental-health
#3
Gennady G Knyazev, Alexander N Savostyanov, Andrey V Bocharov, Daria V Bazovkina, Ekaterina A Proshina
A number of studies have shown that the presence of short (S) allele of the serotonin transporter-linked polymorphic region (5-HTTLPR) is associated with a higher risk for depression following exposure to stressful life events. These findings are in line with neuroimaging studies showing that 5-HTTLPR polymorphism has an effect on the connectivity among key areas involved in emotion regulation. Here using mediated moderation analysis, we show that electrophysiological manifestations of resting state networks in the alpha frequency band mediate the effect of 5-HTTLPR by stress interaction on depression/anxiety symptoms in a nonclinical sample...
November 10, 2017: Neuroscience
https://www.readbyqxmd.com/read/29114103/association-of-serotonin-transporter-gene-alujb-methylation-with-major-depression-amygdala-responsiveness-5-httlpr-rs25531-polymorphism-and-stress
#4
Ilona Schneider, Harald Kugel, Ronny Redlich, Dominik Grotegerd, Christian Bürger, Paul-Christian Bürkner, Nils Opel, Katharina Dohm, Dario Zaremba, Susanne Meinert, Nina Schröder, Anna Milena Straßburg, Kathrin Schwarte, Christiane Schettler, Oliver Ambrée, Stephan Rust, Katharina Domschke, Volker Arolt, Walter Heindel, Bernhard T Baune, Weiqi Zhang, Udo Dannlowski, Christa Hohoff
DNA methylation profiles of the serotonin transporter gene (SLC6A4) have been shown to alter SLC6A4 expression, drive antidepressant treatment response and modify brain functions. This study investigated whether methylation of an AluJb element in the SLC6A4 promotor was associated with major depressive disorder (MDD), amygdala reactivity to emotional faces, 5-HTTLPR/rs25531 polymorphism, and recent stress. MDD patients (n=122) and healthy controls (HC, n=176) underwent fMRI during an emotional face-matching task...
November 7, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29106784/lucky-gene-5-httlpr-and-postpartum-depression-a-systematic-review
#5
(no author information available yet)
BACKGROUND: Postpartum depression (PPD) should be given more attention for its increasing incidences, severe complications and complex pathogenesis. Previous studies of PPD have mainly been focused on the social contributions to its etiology such as age, marriage and economic status, whilst less attention has been given to inner biological factors. Currently, emerging researches have endeavored to explore 5-HTT related pathogenesis of PPD. OBJECTIVE: This report was aimed at proffering updates on some research advancements in the field of PPD through the reviewing published papers concerning postpartum depression, with prime focus on the role of 5-HTT...
October 6, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29102815/combining-genetic-and-epigenetic-parameters-of-the-serotonin-transporter-gene-in-obsessive-compulsive-disorder
#6
Edna Grünblatt, Zoya Marinova, Alexander Roth, Elena Gardini, Juliane Ball, Julia Geissler, Tomasz K Wojdacz, Marcel Romanos, Susanne Walitza
While genetic variants have been reported to be associated with obsessive-compulsive disorder (OCD), the small effect sizes suggest that epigenetic mechanisms such as DNA methylation may also be relevant. The serotonin transporter (SLC6A4) gene has been extensively investigated in relation to OCD, since serotonin reuptake inhibitors are the pharmacological treatment of choice for the disorder. The current study set three questions: Firstly, whether the high expressing loci of the SLC6A4 polymorphisms, 5-HTTLPR + rs25531, rs25532 and rs16965628 are associated with family-based (n = 164 trios) and case-control OCD (n = 186, 152, respectively)...
October 16, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29094757/sometimes-it-s-good-to-be-short-the-serotonin-transporter-gene-positive-parenting-and-adolescent-depression
#7
Keriann Little, Craig A Olsson, Sarah Whittle, Jacqui A Macdonald, Lisa B Sheeber, George J Youssef, Julian G Simmons, Ann V Sanson, Debra L Foley, Nicholas B Allen
In threatening environments, the short (S) allele of 5-HTTLPR is proposed to augment risk for depression. However, it is unknown whether 5-HTTLPR variation increases risk for depression in environments of deprivation, lacking positive or nurturant features. Two independent longitudinal studies (n = 681 and 176, respectively) examined whether 5-HTTLPR moderated associations between low levels of positive parenting at 11-13 years and subsequent depression at 17-19 years. In both studies only LL homozygous adolescents were at greater risk for depression with decreasing levels of positive parenting...
November 2, 2017: Child Development
https://www.readbyqxmd.com/read/29090386/serotonin-transporter-polymorphism-depressive-symptoms-and-emotional-impulsivity-among-advanced-breast-cancer-patients
#8
Youngmee Kim, Charles S Carver, Joachim F Hallmayer, Jamie M Zeitzer, Oxana Palesh, Eric Neri, Bita Nouriani, David Spiegel
PURPOSE: This study tested a theory linking a marker of low serotonergic function to both depression and impulsivity in a sample of advanced breast cancer patients, among whom elevated depressive symptoms and difficulty regulating emotions are commonly reported. METHODS: A total of 95 patients provided blood samples for serotonin transporter polymorphic region of the gene (5-HTTLPR) and completed questionnaires that measured depressive symptoms and emotional impulsivity...
October 31, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29033635/evaluation-of-5-httlpr-gene-polymorphism-and-resilience-components-on-the-development-of-psychopathology-in-adolescent-sexual-abuse-cases
#9
Gresa Çarkaxhiu Bulut, Ayşe Rodopman Arman, İlter Güney, Pınar Gültepe
INTRODUCTION: More than one-fourth adolescents are exposed to unexpected frightening experiences and traumas until adulthood. In this study, we aimed to determine the potential role of serotonin transporter (5-HTT) gene polymorphism regarding resilience factors in the symptom variability of individuals exposed to sexual abuse. METHODS: Adolescents aged 11-17 years, who were admitted to the Marmara University Child Psychiatry Outpatient Clinic Forensic division with sexual abuse experience history, were informed about the research, and volunteers were included in the study...
September 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29031184/gene-environment-interactions-between-stress-and-5-httlpr-in-depression-a-meta-analytic-update
#10
REVIEW
Dries Bleys, Patrick Luyten, Bart Soenens, Stephan Claes
BACKGROUND: Meta-analyses have yielded contradictory findings concerning the role of 5-HTTLPR in interaction with stress (GxE) in depression. The current meta-analysis investigates if these contradictory findings are a result of differences between studies in methodological approaches towards the assessment of stress and depression. METHODS: After performing a systematic database search (February to December 2016), first, a meta-analysis was used to investigate the total effect size and publication bias...
October 3, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29030421/serotonin-transporter-gene-polymorphisms-may-be-associated-with-poststroke-neurological-recovery-after-escitalopram-use
#11
Eun-Jae Lee, Mi-Sun Oh, Jong S Kim, Dae-Il Chang, Jong-Ho Park, Jae-Kwan Cha, Ji Hoe Heo, Sung-Il Sohn, Dong-Eog Kim, Hahn Young Kim, Jei Kim, Woo-Keun Seo, Jun Lee, Sang-Won Park, Yun Joong Kim, Byung-Chul Lee
OBJECTIVE: Selective serotonin reuptake inhibitors (SSRIs) putatively improve neurological recovery after stroke. We aimed to investigate whether serotonin transporter (SERT) gene polymorphisms are related to the responsiveness to SSRIs in the poststroke neurological recovery. METHODS: This was a post hoc analysis of the EMOTION study (ClinicalTrials.gov NCT01278498), a randomised, placebo-controlled, double-blind trial examining the efficacy of escitalopram on emotional and neurological disturbances after acute stroke...
October 13, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29016262/association-of-5-httlpr-polymorphism-with-the-nursing-diagnoses-and-the-achievement-of-nursing-outcomes-in-patients-with-major-depression
#12
Margarita Prokofieva, Georgia Karadima, Evmorfia Koukia, Vassiliki Michou, Chrysoula Kyprianidou, Chrysovalantis V Papageorgiou, Evangelos Alexiadis, Pantelis Constantoulakis, Dimitris Dikeos
The aim of this study is to investigate whether a 44-base-pair insertion/deletion polymorphism in the upstream regulatory region of the serotonin transporter gene (5-HTTLPR) is associated with the nursing diagnoses and the achievement of the desired nursing outcomes in inpatients with major depression. Thirty five patients were evaluated. The nursing diagnoses of risk for suicide and imbalanced nutrition are reported less often in homozygotes of the high-expressing gene (LA). Carriers of the low-expressing genes (LG or S) have a worse response to interventions which aim to increase low self-esteem, indicating that they may need more intensive care in order to achieve the desired outcome...
October 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/28969722/the-interaction-between-5-httlpr-genotype-and-ruminative-thinking-on-bmi
#13
Robbie Schepers, C Robert Markus
Negative affect or stress is often found to increase energy intake for high palatable energy-rich foods and hence weight gain. Reduced brain serotonin (5-HT) function is known to increase stress vulnerability and the risk for eating-related disturbances. A short (S) allele polymorphism in the serotonin transporter gene (5-HTTLPR) is associated with a less efficient functioning brain serotonin system and therefore higher stress vulnerability. It has been suggested that this genotype may be directly linked to an increased risk for weight gain and/or obesity...
October 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28951738/serotonin-related-gene-variants-in-patients-with-irritable-bowel-syndrome-and-depressive-or-anxiety-disorders
#14
Magdalena Grzesiak, Jan Aleksander Beszłej, Ewa Waszczuk, Marcin Szechiński, Monika Szewczuk-Bogusławska, Dorota Frydecka, Tadeusz Dobosz, Anna Jonkisz, Arleta Lebioda, Małgorzata Małodobra, Agata Mulak
AIM: To assess the association of six polymorphisms in serotonin-related genes with depressive or anxiety disorders in patients with irritable bowel syndrome (IBS). METHODS: The lifetime prevalence of depressive and anxiety disorders was assessed in 95 IBS patients (85% women) using the Munich version of the Composite International Diagnostic Interview (CIDI). IBS was diagnosed according to the Rome III criteria. SCL6A4 HTTLPR polymorphism (rs4795541) was determined using PCR-based method...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28924185/5-httlpr-%C3%A3-stress-hypothesis-is-the-debate-over
#15
M-L Ancelin, J Ryan
No abstract text is available yet for this article.
September 19, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28921740/5-httlpr-moderates-the-association-between-interdependence-and-brain-responses-to-mortality-threats
#16
Siyang Luo, Dian Yu, Shihui Han
While behavioral research suggests an association between cultural worldview and decreased anxiety of death, the underlying neurobiological mechanisms remain unclear. Using functional MRI, we investigated whether and how the serotonin transporter promoter polymorphism (5-HTTLPR), which has been associated with mental disorders such as anxiety and depression, moderates the associations between a cultural trait (i.e., interdependence) and self-report of death anxiety/depression and between interdependence and brain responses to mortality threats...
September 17, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28914102/5-httlpr-brain-derived-neurotrophic-factor-bdnf-gene-interactions-and-early-adverse-life-events-effect-on-impulsivity-in-suicide-attempters
#17
Luis Jiménez-Treviño, Pilar Alejandra Saiz, Maria Paz García-Portilla, Hilario Blasco-Fontecilla, Vladimir Carli, Miriam Iosue, Isabelle Jaussent, Jorge López-Castroman, Concepcion Vaquero-Lorenzo, Marco Sarchiapone, Enrique Baca-García, Philippe Courtet, Julio Bobes
OBJECTIVES: An expanding body of research suggests that childhood adverse experiences can lead to different negative health outcomes, including attempted suicide. Serotonergic genes such as the promoter region of the serotonin transporter gene (5-HTTLPR) have been associated both with impulsivity in suicide attempts and reactivity to environmental stress exposure. BDNF gene may play an epigenetic role. METHODS: We studied the influence of childhood stressful events and 5-HTTLPR genotype on impulsivity measured by Barratt Impulsivity Scale (BIS-10) in a multicentre sample of 1,655 suicide attempters (69...
September 15, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28901577/suppression-mediates-the-effect-of-5-httlpr-by-stress-interaction-on%C3%A2-depression
#18
Gennady G Knyazev, Daria V Bazovkina, Alexander N Savostyanov, Vladimir S Naumenko, Valeriya B Kuznetsova, Ekaterina A Proshina
A number of studies have shown that the presence of short (S), as opposed to long (L), allele of the serotonin transporter-linked polymorphic region (5-HTTLPR) is associated with a higher risk for depression following exposure to stressful life events. However, many other studies failed to confirm this association. One reason for this inconsistency might be the fact that the interaction of the 5-HTTLPR polymorphism with stress may relate not to depression per se, but rather to adaptive or maladaptive emotion regulation strategies...
October 2017: Scandinavian Journal of Psychology
https://www.readbyqxmd.com/read/28892067/association-of-the-serotonin-transporter-linked-polymorphic-region-genotype-with-lower-bone-mineral-density
#19
M I Lapid, S Kung, M A Frye, J M Biernacka, J R Geske, M T Drake, M D Jankowski, B L Clarke
The serotonin transporter-linked polymorphic region (5-HTTLPR) of the serotonin transporter gene (SLC6A4) S allele is linked to pathogenesis of depression and slower response to selective serotonin reuptake inhibitors (SSRIs); depression and SSRIs are independently associated with bone loss. We aimed to determine whether 5-HTTLPR was associated with bone loss. This cross-sectional study included psychiatric patients with both 5-HTTLPR analysis and bone mineral density (BMD) assessment (hip and spine Z-scores if age <50 years and T-scores if ⩾50 years)...
August 22, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28890225/early-life-stress-predicts-negative-urgency-through-brooding-depending-on-5-httlpr-genotype-a-pilot-study-with-6-month-follow-up-examining-suicide-ideation
#20
Jorge Valderrama, Regina Miranda
The present study examined the interaction between early life stress and 5-HTT genotypes in predicting two risk factors for suicidal behavior - the brooding subtype of rumination and impulsivity, in the form of negative urgency - over time. Furthermore, we examined early life stress, brooding, and impulsivity as predictors of suicidal ideation over time. Participants with and without a history of early life stress were genotyped for the 5-HTTLPR polymorphism and completed assessments assessing brooding and negative urgency at baseline and 6-month follow up...
December 2017: Psychiatry Research
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