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https://www.readbyqxmd.com/read/29757125/cross-cultural-comparison-of-genetic-and-cultural-transmission-of-smoking-initiation-using-an-extended-twin-kinship-model
#1
Hermine H Maes, Kate Morley, Michael C Neale, Kenneth S Kendler, Andrew C Heath, Lindon J Eaves, Nicholas G Martin
BACKGROUND: Considerable evidence from twin and adoption studies indicates that genetic and shared environmental factors play a role in the initiation of smoking behavior. Although twin and adoption designs are powerful to detect genetic and environmental influences, they do not provide information on the processes of assortative mating and parent-offspring transmission and their contribution to the variability explained by genetic and/or environmental factors. METHODS: We examined the role of genetic and environmental factors in individual differences for smoking initiation (SI) using an extended kinship design...
May 14, 2018: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/29729685/common-genetic-contributions-to-high-risk-trauma-exposure-and-self-injurious-thoughts-and-behaviors
#2
Leah S Richmond-Rakerd, Timothy J Trull, Ian R Gizer, Kristin McLaughlin, Emily M Scheiderer, Elliot C Nelson, Arpana Agrawal, Michael T Lynskey, Pamela A F Madden, Andrew C Heath, Dixie J Statham, Nicholas G Martin
BACKGROUND: Prior research has documented shared heritable contributions to non-suicidal self-injury (NSSI) and suicidal ideation (SI) as well as NSSI and suicide attempt (SA). In addition, trauma exposure has been implicated in risk for NSSI and suicide. Genetically informative studies are needed to determine common sources of liability to all three self-injurious thoughts and behaviors, and to clarify the nature of their associations with traumatic experiences. METHODS: Multivariate biometric modeling was conducted using data from 9526 twins [59% female, mean age = 31...
May 6, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29718191/metacompare-a-computational-pipeline-for-prioritizing-environmental-resistome-risk
#3
Min Oh, Amy Pruden, Chaoqi Chen, Lenwood S Heath, Kang Xia, Liqing Zhang
The spread of antibiotic resistance is a growing public health concern. While numerous studies have highlighted the importance of environmental sources and pathways of the spread of antibiotic resistance, a systematic means of comparing and prioritizing risks represented by various environmental compartments is lacking. Here we introduce MetaCompare, a publicly-available tool for ranking 'resistome risk,' which we define as the potential for antibiotic resistance genes (ARGs) to be associated with mobile genetic elements (MGEs) and mobilize to pathogens based on metagenomic data...
April 26, 2018: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29692273/extended-twin-study-of-alcohol-use-in-virginia-and-australia
#4
Brad Verhulst, Michael C Neale, Lindon J Eaves, Sarah E Medland, Andrew C Heath, Nicholas G Martin, Hermine H Maes
Drinking alcohol is a normal behavior in many societies, and prior studies have demonstrated it has both genetic and environmental sources of variation. Using two very large samples of twins and their first-degree relatives (Australia ≈ 20,000 individuals from 8,019 families; Virginia ≈ 23,000 from 6,042 families), we examine whether there are differences: (1) in the genetic and environmental factors that influence four interrelated drinking behaviors (quantity, frequency, age of initiation, and number of drinks in the last week), (2) between the twin-only design and the extended twin design, and (3) the Australian and Virginia samples...
April 25, 2018: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/29651457/light-induced-dynamic-structural-color-by-intracellular-3d-photonic-crystals-in-brown-algae
#5
Martin Lopez-Garcia, Nathan Masters, Heath E O'Brien, Joseph Lennon, George Atkinson, Martin J Cryan, Ruth Oulton, Heather M Whitney
Natural photonic crystals are responsible for strong reflectance at selective wavelengths in different natural systems. We demonstrate that intracellular opal-like photonic crystals formed from lipids within photosynthetic cells produce vivid structural color in the alga Cystoseira tamariscifolia . The reflectance of the opaline vesicles is dynamically responsive to environmental illumination. The structural color is present in low light-adapted samples, whereas higher light levels produce a slow disappearance of the structural color such that it eventually vanishes completely...
April 2018: Science Advances
https://www.readbyqxmd.com/read/29626821/biomarkers-of-exposure-in-environment-wide-association-studies-opportunities-to-decode-the-exposome-using-human-biomonitoring-data
#6
REVIEW
Nadine Steckling, Alberto Gotti, Stephan Bose-O'Reilly, Dimitris Chapizanis, Danae Costopoulou, Frank De Vocht, Mercè Garí, Joan O Grimalt, Ester Heath, Rosemary Hiscock, Marta Jagodic, Spyros P Karakitsios, Kleopatra Kedikoglou, Tina Kosjek, Leondios Leondiadis, Thomas Maggos, Darja Mazej, Kinga Polańska, Andrew Povey, Joaquim Rovira, Julia Schoierer, Marta Schuhmacher, Zdravko Špirić, Anja Stajnko, Rob Stierum, Janja Snoj Tratnik, Irene Vassiliadou, Isabella Annesi-Maesano, Milena Horvat, Dimosthenis A Sarigiannis
BACKGROUND: The European Union's 7th Framework Programme (EU's FP7) project HEALS - Health and Environment-wide Associations based on Large Population Surveys - aims a refinement of the methodology to elucidate the human exposome. Human biomonitoring (HBM) provides a valuable tool for understanding the magnitude of human exposure from all pathways and sources. However, availability of specific biomarkers of exposure (BoE) is limited. OBJECTIVES: The objective was to summarize the availability of BoEs for a broad range of environmental stressors and exposure determinants and corresponding reference and exposure limit values and biomonitoring equivalents useful for unraveling the exposome using the framework of environment-wide association studies (EWAS)...
April 4, 2018: Environmental Research
https://www.readbyqxmd.com/read/29569228/model-averaged-confounder-adjustment-for-estimating-multivariate-exposure-effects-with-linear-regression
#7
Ander Wilson, Corwin M Zigler, Chirag J Patel, Francesca Dominici
In environmental and nutritional epidemiology and in many other fields, there is increasing interest in estimating the effect of simultaneous exposure to several agents (e.g., multiple nutrients, pesticides, or air pollutants) on a health outcome. We consider estimating the effect of a multivariate exposure that includes several continuous agents and their interactions-on an outcome, when the true confounding variables are an unknown subset of a potentially large (relative to sample size) set of measured covariates...
March 22, 2018: Biometrics
https://www.readbyqxmd.com/read/29536413/single-cell-mass-spectrometry-reveals-changes-in-lipid-and-metabolite-expression-in-raw-264-7-cells-upon-lipopolysaccharide-stimulation
#8
Bo Yang, Nathan Heath Patterson, Tina Tsui, Richard M Caprioli, Jeremy L Norris
It has been widely recognized that individual cells that exist within a large population of cells, even if they are genetically identical, can have divergent molecular makeups resulting from a variety of factors, including local environmental factors and stochastic processes within each cell. Presently, numerous approaches have been described that permit the resolution of these single-cell expression differences for RNA and protein; however, relatively few techniques exist for the study of lipids and metabolites in this manner...
March 13, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29391044/deeparg-a-deep-learning-approach-for-predicting-antibiotic-resistance-genes-from-metagenomic-data
#9
Gustavo Arango-Argoty, Emily Garner, Amy Pruden, Lenwood S Heath, Peter Vikesland, Liqing Zhang
BACKGROUND: Growing concerns about increasing rates of antibiotic resistance call for expanded and comprehensive global monitoring. Advancing methods for monitoring of environmental media (e.g., wastewater, agricultural waste, food, and water) is especially needed for identifying potential resources of novel antibiotic resistance genes (ARGs), hot spots for gene exchange, and as pathways for the spread of ARGs and human exposure. Next-generation sequencing now enables direct access and profiling of the total metagenomic DNA pool, where ARGs are typically identified or predicted based on the "best hits" of sequence searches against existing databases...
February 1, 2018: Microbiome
https://www.readbyqxmd.com/read/29358382/prediction-of-inherited-genomic-susceptibility-to-20-common-cancer-types-by-a-supervised-machine-learning-method
#10
Byung-Ju Kim, Sung-Hou Kim
Prevention and early intervention are the most effective ways of avoiding or minimizing psychological, physical, and financial suffering from cancer. However, such proactive action requires the ability to predict the individual's susceptibility to cancer with a measure of probability. Of the triad of cancer-causing factors (inherited genomic susceptibility, environmental factors, and lifestyle factors), the inherited genomic component may be derivable from the recent public availability of a large body of whole-genome variation data...
February 6, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29356454/correlates-of-immune-defenses-in-golden-eagle-nestlings
#11
Elisabeth MacColl, Kris Vanesky, Jeremy A Buck, Benjamin M Dudek, Collin A Eagles-Smith, Julie A Heath, Garth Herring, Chris Vennum, Cynthia J Downs
An individual's investment in constitutive immune defenses depends on both intrinsic and extrinsic factors. We examined how Leucocytozoon parasite presence, body condition (scaled mass), heterophil-to-lymphocyte (H:L) ratio, sex, and age affected immune defenses in golden eagle (Aquila chrysaetos) nestlings from three regions: California, Oregon, and Idaho. We quantified hemolytic-complement activity and bacterial killing ability, two measures of constitutive immunity. Body condition and age did not affect immune defenses...
June 2017: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/29321859/habitat-related-seed-germination-traits-in-alpine-habitats
#12
Maria Tudela-Isanta, Eduardo Fernández-Pascual, Malaka Wijayasinghe, Simone Orsenigo, Graziano Rossi, Hugh W Pritchard, Andrea Mondoni
Understanding the key aspects of plant regeneration from seeds is crucial in assessing species assembly to their habitats. However, the regenerative traits of seed dormancy and germination are underrepresented in this context. In the alpine zone, the large species and microhabitat diversity provide an ideal context to assess habitat-related regenerative strategies. To this end, seeds of 53 species growing in alpine siliceous and calcareous habitats (6230 and 6170 of EU Directive 92/43, respectively) were exposed to different temperature treatments under controlled laboratory conditions...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29321846/weak-whole-plant-trait-coordination-in-a-seasonally-dry-south-american-stressful-environment
#13
José L A Silva, Alexandre F Souza, Adriano Caliman, Eduardo L Voigt, Juliana E Lichston
A core question involving both plant physiology and community ecology is whether traits from different organs are coordinated across species, beyond pairwise trait correlations. The strength of within-community trait coordination has been hypothesized to increase along gradients of environmental harshness, due to the cost of adopting ecological strategies out of the viable niche space supported by the abiotic conditions. We evaluated the strength of trait relationship and coordination in a stressful environment using 21 leaf and stem traits of 21 deciduous and evergreen woody species from a heath vegetation growing on coastal sandy plain in northeastern South America...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29234168/environmental-and-genetic-determinants-of-transcriptional-plasticity-in-chinook-salmon
#14
Kyle W Wellband, John W Heath, Daniel D Heath
Variation in gene transcription is widely believed to be the mechanistic basis of phenotypically plastic traits; however, comparatively little is known about the inheritance patterns of transcriptional variation that would allow us to predict its response to selection. In addition, acclimation to different environmental conditions influences acute transcriptional responses to stress and it is unclear if these effects are heritable. To address these gaps in knowledge, we assayed levels of messenger RNA for 14 candidate genes at rest and in response to a 24-h confinement stress for 72 half-sib families of Chinook salmon reared in two different environments (hatchery and semi-natural stream channel)...
January 2018: Heredity
https://www.readbyqxmd.com/read/29230402/animal-health-surveillance-in-scotland-in-2030-using-scenario-planning-to-develop-strategies-in-the-context-of-brexit
#15
Lisa A Boden, Harriet Auty, Aaron Reeves, Gustaf Rydevik, Paul Bessell, Iain J McKendrick
Animal health surveillance is necessary to protect human and animal health, rural economies, and the environment from the consequences of large-scale disease outbreaks. In Scotland, since the Kinnaird review in 2011, efforts have been made to engage with stakeholders to ensure that the strategic goals of surveillance are better aligned with the needs of the end-users and other beneficiaries. The aims of this study were to engage with Scottish surveillance stakeholders and multidisciplinary experts to inform the future long-term strategy for animal health surveillance in Scotland...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29228035/landscape-effects-on-demersal-fish-revealed-by-field-observations-and-predictive-seabed-modelling
#16
Sophie A M Elliott, Alessandro D Sabatino, Michael R Heath, William R Turrell, David M Bailey
Nature conservation and fisheries management often focus on particular seabed features that are considered vulnerable or important to commercial species. As a result, individual seabed types are protected in isolation, without any understanding of what effect the mixture of seabed types within the landscape has on ecosystem functions. Here we undertook predictive seabed modelling within a coastal marine protected area using observations from underwater stereo-video camera deployments and environmental information (depth, wave fetch, maximum tidal speeds, distance from coast and underlying geology)...
2017: PloS One
https://www.readbyqxmd.com/read/29216484/beliefs-about-the-causes-of-and-treatments-for-depression-and-bipolar-disorder-among-south-koreans
#17
Subin Park, Hyesue Jang, Adrian Furnham, Mina Jeon, Se Jin Park
Public beliefs about psychiatric disorders are important for understanding help-seeking behaviours. We investigated factors that affect South Koreans' beliefs about the causes and treatment of depression and bipolar disorder. We recruited 654 participants aged 15-54 years using an online panel survey. Participants completed two questionnaires: 34 possible causes of and 33 possible treatments for depression and bipolar disorder. For both disorders, the questionnaires about causes revealed four factors: social-environmental, God/fate, heath/lifestyle, and biological; the questionnaires about treatments revealed five factors: self-help/stress management, physical treatment/health management, seeking mental health services, religious help, and resting...
November 21, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29201868/the-scope-of-big-data-in-one-medicine-unprecedented-opportunities-and-challenges
#18
REVIEW
Molly E McCue, Annette M McCoy
Advances in high-throughput molecular biology and electronic health records (EHR), coupled with increasing computer capabilities have resulted in an increased interest in the use of big data in health care. Big data require collection and analysis of data at an unprecedented scale and represents a paradigm shift in health care, offering (1) the capacity to generate new knowledge more quickly than traditional scientific approaches; (2) unbiased collection and analysis of data; and (3) a holistic understanding of biology and pathophysiology...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29141146/the-effect-of-pressure-and-temperature-on-mid-infrared-sensing-of-dissolved-hydrocarbons-in-water
#19
Charles Heath, Matthew Myers, Bobby Pejcic
Attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy using a polymer coated internal reflection element/waveguide is an established sensor platform for the detection of a range of organic and hydrocarbon molecules dissolved in water. The polymer coating serves two purposes: to concentrate hydrocarbons from the aqueous phase and to exclude water along with other interfering molecules from the surface of the internal reflection element. Crucial to reliable quantification and analytical performance is the calibration of the ATR-FTIR sensor which is commonly performed in water under mild ambient conditions (i...
December 19, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29123345/effect-of-supportive-psychotherapy-on-mental-health-status-and-quality-of-life-of-female-cancer-patients-receiving-chemotherapy-for-recurrent-disease
#20
Anindita Mukherjee, Koustav Mazumder, Vikrant Kaushal, Sushmita Ghoshal
Context: Cancer patients receiving chemotherapy for their recurrent disease often report the presence of anxiety and depression. Aims: In the study, we intended to find out the mental health status and overall quality of life (QOL) of such patients and to identify the effect of supportive psychotherapy. Subjects and Methods: Forty cancer patients undergoing second or subsequent line chemotherapy(CCT) were selected for psychotherapy session...
October 2017: Indian Journal of Palliative Care
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