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fibroid and infertility

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https://www.readbyqxmd.com/read/28930223/successful-pregnancy-after-treatment-with-chinese-herbal-medicine-in-a-43-year-old-woman-with-diminished-ovarian-reserve-and-multiple-uterus-fibrosis-a-case-report
#1
Benqi Teng, Jie Peng, Madeleine Ong, Xianqin Qu
OBJECTIVE: To highlight a natural approach to coexisting oligomenorrhea, subfertility, luteal phase insufficiency and multiple fibroids cohesively when in vitro fertilisation (IVF) has failed. CASE PRESENTATION: A 43-year-old woman with diminished ovarian reserve and multiple uterine fibroids had previously been advised to discontinue IVF treatment. According to Chinese Medicine diagnosis, herbal formulae were prescribed for improving age-related ovarian insufficiency as well as to control the growth of fibroids...
February 9, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28922305/mayer-rokitansky-k%C3%A3-ster-hauser-syndrome-with-bilateral-ovarian-sertoli-cell-tumors-review-of-the-literature-and-report-of-a-rare-case
#2
Alexander L Juusela, Ilana Naghi, Suresh Thani
BACKGROUND: Patients with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome are infertile secondary to hypoplasia or complete agenesis of the uterus, yet they remain at risk of primary neoplasms of the ovaries because embryologically the uterus and ovaries develop via separate mechanisms. CASE: A 72-year-old nulliparous woman with a history of primary amenorrhea underwent an exploratory laparotomy for a suspected uterine fibroid. In addition to the pelvic mass, the patient was found to have findings consistent with MRKH syndrome...
September 15, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28885274/fertility-preserved-hysteroscopic-approach-for-the-treatment-of-stage-ia-endometrioid-carcinoma
#3
Fangfang Wang, Aijun Yu, Haichao Xu, Xiaojing Zhang, Li Li, Hanmei Lou, Hua Yu, Jun Lin
OBJECTIVE: This study aims to explore the feasibility of a hysteroscopic procedure combined with progestin therapy in young patients with stage Ia endometrioid carcinoma (EC) to avoid sterilization. MATERIALS AND METHODS: Eleven young women with stage Ia EC (International Federation of Gynecology and Obstetrics grade 1) who were treated with a hysteroscopic approach combined with progestin from July 2004 to June 2016 were retrospectively analyzed and followed up to monitor their general recovery and pregnancy outcome...
September 6, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28867860/ayurvedic-management-of-recurrent-abortions-due-to-uterine-fibroid
#4
Shailendra Dadarao Katakdound
Uterine fibroids are present in 30-70% of women of reproductive age. Uterine fibroids distort the uterine cavity. Therefore there is consensus of a negative impact on both the clinical pregnancy and delivery rates.[2] In addition, studies have also reported an increased risk of spontaneous miscarriage with submucosal fibroids. In biomedicine, myomectomy is considered the treatment of choice and Assisted Reproductive Technology is advised to overcome infertility. In Hārita Saṃhitā treatment is given for recurrent abortion (Garbhasrāvī)...
January 2017: Ancient Science of Life
https://www.readbyqxmd.com/read/28856864/pregnancy-outcomes-in-patients-with-uterine-fibroids-treated-with-ultrasound-guided-high-intensity-focused-ultrasound
#5
M Zou, L Chen, C Wu, C Hu, Y Xiong
OBJECTIVE: To investigate the effect of high-intensity focused ultrasound (HIFU) ablation for uterine fibroids on pregnancy. DESIGN: A retrospective observational study. SETTING: Department of Gynaecology in a single centre in China. POPULATION: Patients with uterine fibroids who wish to become pregnant. METHODS: Patients with uterine fibroids who wished become pregnant and have children, were treated using HIFU from April 2011 to March 2016 at Chongqing Haifu Hospital...
August 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28828592/drug-delivery-for-the-treatment-of-endometriosis-and-uterine-fibroids
#6
REVIEW
David R Friend
Endometriosis and uterine fibroids (also known as uterine leiomyomas) are serious medical conditions affecting large numbers of women worldwide. Many women are asymptomatic but those with symptoms require medical intervention to relieve chronic pain and dysmenorrhea and to address infertility. Drug delivery has played a role in reducing some of the symptoms associated with endometriosis and uterine fibroids. Use of drug delivery systems for both conditions can roughly be divided into two categories: (1) existing systems designed for other indications such as contraception for symptomatic relief and (2) development of novel systems aimed at addressing some of the underlying biochemical changes associated with endometriosis and uterine fibroids such as oxidative stress, angiogenesis, and matrix degradation...
August 21, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28826369/literature-review-on-the-role-of-uterine-fibroids-in-endometrial-function
#7
Deborah E Ikhena, Serdar E Bulun
Uterine fibroids are benign uterine smooth muscle tumors that are present in up to 8 out of 10 women by the age of 50. Many of these women experience symptoms such as heavy and irregular menstrual bleeding, early pregnancy loss, and infertility. Traditionally believed to be inert masses, fibroids are now known to influence endometrial function at the molecular level. We present a comprehensive review of published studies on the effect of uterine fibroids on endometrial function. Our goal was to explore the current knowledge about how uterine fibroids interact with the endometrium and how these interactions influence clinical symptoms...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28815060/defective-expression-of-atg4d-abrogates-autophagy-and-promotes-growth-in-human-uterine-fibroids
#8
Abdeljabar El Andaloussi, Samar Habib, Gizem Soylemes, Archana Laknaur, Heba Elhusseini, Ayman Al-Hendy, Nahed Ismail
Uterine fibroids (UF) are the most common pelvic tumors in women of reproductive-age and they usually cause heavy menstrual bleeding, pain and infertility. Autophagy is a collection of processes that enables the cells to digest and recycle their cytoplasmic contents, such as toxic protein aggregates, defunct or disused organelles and invading microorganisms. Dysregulation in autophagy process were described in neoplasms; however, the contribution of autophagy to the pathogenesis of UF remains unknown. In this study, we demonstrate that autophagy is deregulated in human UF as evidenced by significant accumulation of autophagosome in human UF cells compared to normal myometrium cells...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28753380/ct-and-mr-imaging-of-gynecologic-emergencies
#9
Yuko Iraha, Masahiro Okada, Rin Iraha, Kimei Azama, Tsuneo Yamashiro, Maho Tsubakimoto, Yoichi Aoki, Sadayuki Murayama
Gynecologic emergencies include various diseases that result from adnexal and uterine disorders. Adnexal disorders may be classified into the following three categories: (a) disorders that cause hemorrhage (hemorrhagic ovarian cysts and ectopic pregnancies); (b) disorders related to adnexal tumors (adnexal torsion and rupture of ovarian tumors); and (c) disorders related to pelvic inflammatory disease, such as tubo-ovarian abscesses. Unusual adnexal torsion, such as massive ovarian edema, isolated fallopian tube torsion, and paraovarian cyst torsion, has also been described...
September 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28638108/pregnancy-outcomes-in-nulliparous-women-after-ultrasound-ablation-of-uterine-fibroids-a-single-central-retrospective-study
#10
Jun Shu Li, Yong Wang, Jin Yun Chen, Wen Zhi Chen
To explore the impact of high-intensity focused ultrasound (HIFU) ablation of uterine fibroids in nulliparous women on subsequent pregnancy and delivery. A retrospective analysis was conducted of nulliparous women who received HIFU treatment at Chongqing Medical University, Chongqing,China, from January 1, 2010, to January 1, 2015. A total of 189 cases were enrolled, the median follow-up time was three years. Among them,there were 131 cases pregnancy with a total of 133 times,the pregnancy rate was 69.3% (131/189),and the spontaneous conception rate was 95...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28609115/molecular-targets-of-dietary-phytochemicals-for-possible-prevention-and-therapy-of-uterine-fibroids-focus-on-fibrosis
#11
Md Soriful Islam, Most Mauluda Akhtar, James H Segars, Mario Castellucci, Pasquapina Ciarmela
Uterine fibroids (myomas or leiomyomas) are common benign tumors of reproductive aged women. Fibroids are clinically apparent in 20-50% of women, and cause abnormal uterine bleeding, abdominal pain and discomfort, pregnancy complications and infertility. Unfortunately, limited numbers of medical treatment are available but no effective preventive strategies exist. Moreover, the benefits of medical treatments are tempered by lack of efficacy or serious adverse side effects. Fibrosis has recently been recognized as a key pathological event in leiomyoma development and growth...
November 22, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28553555/magnetic-resonance-imaging-guided-focused-ultrasound-surgery-for-the-treatment-of-symptomatic-uterine-fibroids
#12
Laura Geraci, Alessandro Napoli, Carlo Catalano, Massimo Midiri, Cesare Gagliardo
Uterine fibroids, the most common benign tumor in women of childbearing age, may cause symptoms including pelvic pain, menorrhagia, dysmenorrhea, pressure, urinary symptoms, and infertility. Various approaches are available to treat symptomatic uterine fibroids. Magnetic Resonance-guided Focused Ultrasound Surgery (MRgFUS) represents a recently introduced noninvasive safe and effective technique that can be performed without general anesthesia, in an outpatient setting. We review the principles of MRgFUS, describing patient selection criteria for the treatments performed at our center and we present a series of five selected patients with symptomatic uterine fibroids treated with this not yet widely known technique, showing its efficacy in symptom improvement and fibroid volume reduction...
2017: Case Reports in Radiology
https://www.readbyqxmd.com/read/28523198/uterine-fibroid-torsion-during-pregnancy-a-case-of-laparotomic-myomectomy-at-18-weeks-gestation-with-systematic-review-of-the-literature
#13
Annachiara Basso, Mariana Rita Catalano, Giuseppe Loverro, Serena Nocera, Edoardo Di Naro, Matteo Loverro, Mariateresa Natrella, Salvatore Andrea Mastrolia
Uterine myomas are the most common benign growths affecting female reproductive system, occurring in 20-40% of women, whereas the incidence rate in pregnancy is estimated from 0.1 to 3.9%. The lower incidence in pregnancy is due to the association with infertility and low pregnancy rates and implantation rates after in vitro fertilization treatment. Uterine myomas, usually, are asymptomatic during pregnancy. However, occasionally, pedunculated fibroids torsion or other superimposed complications may cause acute abdominal pain...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28497013/racial-ethnic-disparities-in-environmental-endocrine-disrupting-chemicals-and-women-s-reproductive-health-outcomes-epidemiological-examples-across-the-life-course
#14
Tamarra M James-Todd, Yu-Han Chiu, Ami R Zota
Disparities in women's reproductive health outcomes across the life course have been well-documented. Endocrine disrupting chemicals may be one factor driving disparities, as studies suggest exposure to certain environmental endocrine disrupting chemicals, such as certain phthalates, bisphenol A, parabens and polybrominated diphenyl ethers are higher in non-whites. Yet, a limited amount of research has focused on these chemical exposures as a potential mediator of racial/ethnic differences in women's reproductive health outcomes, such as pubertal development, fibroids, infertility, and pregnancy complications...
June 2016: Current Epidemiology Reports
https://www.readbyqxmd.com/read/28478727/local-upregulation-of-transient-receptor-potential-ankyrin-1-and-transient-receptor-potential-vanilloid-1-ion-channels-in-rectosigmoid-deep-infiltrating-endometriosis
#15
Noémi Bohonyi, Krisztina Pohóczky, Bálint Szalontai, Anikó Perkecz, Krisztina Kovács, Béla Kajtár, Lajos Orbán, Tamás Varga, Sarolta Szegedi, József Bódis, Zsuzsanna Helyes, Miklós Koppán
Transient Receptor Potential Vanilloid 1 (TRPV1) and Transient Receptor Potential Ankyrin 1 (TRPA1) expressed mainly by primary sensory neurons function as major nociceptive integrators. They are also present on the rat endometrium in an oestrogen-regulated manner. TRPV1 is upregulated in peritoneal and ovarian endometriosis patients, but there is no information about TRPA1 and their pathophysiological significances. In this study, patients undergoing laparoscopic surgery were investigated: severe dysmenorrhoea due to rectosigmoid deep infiltrating endometriosis ( n = 15), uterine fibroid-induced moderate dysmenorrhoea ( n = 7) and tubal infertility with no pain ( n = 6)...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28447445/myomectomy-technique-and-current-indications
#16
Hajanirina Rakotomahenina, José Rajaonarison, Lufee Wong, Jean-Luc Brun
Uterine fibroids are the commonest benign tumor of the female genital tract. They affect a significant proportion of reproductive aged women and may cause excessive menstrual bleeding, pelvic pain or pressure, and adversely affect reproductive outcomes. However, many women remain asymptomatic. Fibroids are the first indication for hysterectomy, but myomectomy is the most suitable surgical option for women who desire preservation of their fertility potential. Only a selected group of women of childbearing age will benefit from a myomectomy, as the consequences of myomectomy on reproductive function have remained controversial...
August 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28403922/place-of-ulipristal-acetate-in-the-management-of-uterine-fibroids-preoperative-treatment-or-sequential-treatment
#17
A-G Pourcelot, P Capmas, H Fernandez
Symptomatic uterine fibroids affect 25% of women of childbearing potential and are responsible for various symptoms, mainly menometrorrhagia, pelvic pain and infertility. No currently available medical treatment is able to eradicate fibroids. Two treatments are indicated preoperatively to reduce bleeding and decrease the size of fibroids: GnRH agonists and ulipristal acetate. Ulipristal acetate, a selective progesterone receptor modulator, exerts an antagonist effect on fibroid tissue, inducing apoptosis. It rapidly induces amenorrhoea (after an average of seven days of treatment) and reduces fibroid volume...
March 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28250724/the-influence-of-uterine-artery-embolisation-on-ovarian-reserve-fertility-and-pregnancy-outcomes-a-review-of-literature
#18
REVIEW
Piotr Czuczwar, Anna Stępniak, Wojciech Wrona, Sławomir Woźniak, Paweł Milart, Tomasz Paszkowski
Uterine fibroids are considered to be the most frequent female benign tumours. Fibroids affect mainly women of reproductive age. The most frequently reported signs and symptoms of fibroids include disturbances of the menstrual cycle such as heavy bleeding and painful menstruation, pelvic masses associated with pelvic pain, urinary problems or constipation, as well as infertility and recurrent pregnancy loss. The mainstay of fibroid treatment is still surgery. However, many patients seek alternative treatment options for fibroids, to preserve their uterus and fertility...
December 2016: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28089575/association-of-uterine-fibroids-and-pregnancy-outcomes-after-ovarian-stimulation-intrauterine-insemination-for-unexplained-infertility
#19
RANDOMIZED CONTROLLED TRIAL
Aaron K Styer, Susan Jin, Dan Liu, Baisong Wang, Alex J Polotsky, Mindy S Christianson, Wendy Vitek, Lawrence Engmann, Karl Hansen, Robert Wild, Richard S Legro, Christos Coutifaris, Ruben Alvero, Randal D Robinson, Peter Casson, Gregory M Christman, Alicia Christy, Michael P Diamond, Esther Eisenberg, Heping Zhang, Nanette Santoro
OBJECTIVE: To investigate the association of non-cavity-distorting uterine fibroids and pregnancy outcomes after ovarian stimulation-intrauterine insemination (OS-IUI) in couples with unexplained infertility. DESIGN: Secondary analysis from a prospective, randomized, multicenter clinical trial investigating fertility outcomes after OS-IUI. SETTING: Reproductive Medicine Network clinical sites. PATIENT(S): Nine hundred couples with unexplained infertility who participated in the Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation (AMIGOS) clinical trial...
March 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28063569/prise-en-charge-des-fibromes-ut%C3%A3-rins-en-pr%C3%A3-sence-d-une-infertilit%C3%A3-autrement-inexpliqu%C3%A3-e
#20
Belina Carranza-Mamane, Jon Havelock, Robert Hemmings
OBJECTIF: Formuler des recommandations quant à la façon optimale d'assurer la prise en charge des fibromes dans le contexte de l'infertilité. Les options habituelles et novatrices de prise en charge des fibromes seront analysées en mettant l'accent sur leur applicabilité chez les femmes qui souhaitent obtenir une grossesse. OPTIONS: La prise en charge des fibromes chez les femmes qui souhaitent obtenir une grossesse met d'abord en jeu la documentation de la présence des fibromes en question et la détermination de la probabilité que ces derniers affectent le potentiel génésique...
December 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
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