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Adiponectin, obstructive sleep apnea

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https://www.readbyqxmd.com/read/27651112/inflammation-mediates-the-association-between-visceral-adiposity-and-obstructive-sleep-apnea-in-adolescents
#1
Jordan Gaines, Alexandros N Vgontzas, Julio Fernandez-Mendoza, Susan L Calhoun, Fan He, Duanping Liao, Marjorie D Sawyer, Edward O Bixler
Only a handful of studies, primarily in clinical samples, have reported an association between obesity, inflammation, and obstructive sleep apnea (OSA) in children and adolescents. No studies, however, have examined the pathogenetic link between visceral adiposity, systemic inflammation, and incident OSA in a large general population sample using objective measures of sleep and body fat. Adolescents (n = 392; mean age 17.0 ± 2.2 yr, 54.0% male) from the Penn State Child Cohort (PSCC) underwent 9-h overnight polysomnography; a DXA scan to assess body fat distribution; and a single fasting blood draw for the assessment of plasma interleukin-6 (IL-6), IL-6 soluble receptor (IL-6 sR), tumor necrosis factor alpha (TNFα), tumor necrosis factor receptor 1A (TNFR1), C-reactive protein (CRP), leptin, and adiponectin levels via ELISA...
November 1, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27615447/intermittent-hypoxia-in-obese-zucker-rats-cardiometabolic-and-inflammatory-effects
#2
Anne Briançon-Marjollet, Denis Monneret, Marion Henri, Marie Joyeux-Faure, Perle Totoson, Sandrine Cachot, Patrice Faure, Diane Godin-Ribuot
What is the central question of this study? This study addresses the relative impact of obesity and intermittent hypoxia in the pathophysiological process of obstructive sleep apnoea by investigating the metabolic, inflammatory and cardiovascular consequences of intermittent hypoxia in lean and obese Zucker rats. What is the main finding and its importance? We found that obesity and intermittent hypoxia have mainly distinct consequences on the investigated inflammatory and cardiometabolic parameters in Zucker rats...
October 5, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27470682/evaluation-of-adiponectin-profile-in-italian-patients-affected-by-obstructive-sleep-apnea-syndrome
#3
Donato Lacedonia, Ersilia Nigro, Maria Gabriella Matera, Olga Scudiero, Maria Ludovica Monaco, Rita Polito, Giovanna Elisiana Carpagnano, Maria Pia Foschino Barbaro, Gennaro Mazzarella, Andrea Bianco, Aurora Daniele
Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder; obesity represents a major risk factor for the development and progression of OSAS although obese patients do not necessarily suffer from OSAS. Adipose tissue communicates with lung in both physiologic and pathologic conditions through the production of adipokines, hormones active in metabolic and inflammatory processes. To explore the extent to which Acrp30 impacts on pathophysiology of OSAS and whether these proteins could be considered as targets for both diagnosis and therapy through enzyme-linked immunosorbent assay, western blotting analysis and fast protein liquid chromatography we have analyzed total levels as well as oligomer distribution in OSAS patients...
October 2016: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/26910598/effect-of-continuous-positive-airway-pressure-on-glycemic-control-in-patients-with-obstructive-sleep-apnea-and-type-2-diabetes-a-randomized-clinical-trial
#4
Elisabet Martínez-Cerón, Beatriz Barquiel, Ana-Maria Bezos, Raquel Casitas, Raúl Galera, Cristina García-Benito, Angel Hernanz, Alberto Alonso-Fernández, Francisco Garcia-Rio
RATIONALE: Obstructive sleep apnea (OSA) is a risk factor for type 2 diabetes that adversely impacts glycemic control. However, there is little evidence about the effect of continuous positive airway pressure (CPAP) on glycemic control in patients with diabetes. OBJECTIVES: To assess the effect of CPAP on glycated hemoglobin (HbA1c) levels in patients with suboptimally controlled type 2 diabetes and OSA, and to identify its determinants. METHODS: In a 6-month, open-label, parallel, and randomized clinical trial, 50 patients with OSA and type 2 diabetes and two HbA1c levels equal to or exceeding 6...
August 15, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/26674570/serum-adiponectin-level-in-obstructive-sleep-apnea-relation-of-adiponectin-to-obesity-and-long-term-continuous-positive-airway-pressure-therapy
#5
Milada Hobzová, Richard Salzman, David Stejskal, Jana Zapletalová, Vítězslav Kolek
PURPOSE: The study aimed to determine the effect of OSA and obesity on the plasma levels of adiponectin and the long-term effect of CPAP on its plasma levels and obesity parameters. MATERIAL/METHODS: A prospective observational study included 159 newly diagnosed OSA patients. The cohort was divided into CPAP treated (n=82) and control group (n=77). Both groups were examined at the beginning and a year later. The CPAP-treated patients were additionally tested after a month of therapy...
March 2016: Advances in Medical Sciences
https://www.readbyqxmd.com/read/26429654/obstructive-sleep-apnea-is-independently-associated-with-inflammation-and-insulin-resistance-but-not-with-blood-pressure-%C3%A2-plasma-catecholamines-and-endothelial-function-in%C3%A2-obese-subjects
#6
Luciene da Silva Araújo, Julia Freitas Rodrigues Fernandes, Márcia Regina Simas Torres Klein, Antonio Felipe Sanjuliani
OBJECTIVES: Obstructive sleep apnea (OSA) is associated with an increased risk of cardiovascular disease (CVD). Several of the proposed mechanisms for the development of CVD in OSA are similar to those proposed for the increased risk of CVD in obesity, so that it is difficult to determine the influence of OSA on these pathogenic mechanisms in obese individuals. The aim of this study was to evaluate the relationship of OSA with endothelial function, oxidative stress, inflammatory biomarkers, metabolic profile, sympathetic nervous system activity, and blood pressure (BP) in obese individuals...
November 2015: Nutrition
https://www.readbyqxmd.com/read/26367527/effect-of-continuous-positive-airway-pressure-on-adiponectin-in-patients-with-obstructive-sleep-apnea-a-meta-analysis
#7
Li-Da Chen, Jian-Nan Liu, Li Lin, Zhi Wu, Hao Li, Yu-Ming Ye, Qiao-Zhen Xu, Qi-Chang Lin
OBJECTIVE: Obstructive sleep apnea (OSA) has been suggested to be associated with low levels of adiponectin. Continuous positive airway pressure (CPAP) is the gold standard treatment for OSA; however, previous studies assessing the effect of CPAP on adiponectin in patients with OSA yielded conflicting results. The present meta-analysis was performed to determine whether CPAP therapy could increase adiponectin levels. METHODS: Two reviewers independently searched PubMed, Cochrane library, Embase and Web of Science before February 2015...
2015: PloS One
https://www.readbyqxmd.com/read/25808226/association-between-endothelial-function-assessed-on-reactive-hyperemia-peripheral-arterial-tonometry-and-obstructive-sleep-apnea-visceral-fat-accumulation-and-serum-adiponectin
#8
Masanori Azuma, Yuichi Chihara, Chikara Yoshimura, Kimihiko Murase, Satoshi Hamada, Ryo Tachikawa, Takeshi Matsumoto, Morito Inouchi, Kiminobu Tanizawa, Tomohiro Handa, Toru Oga, Michiaki Mishima, Kazuo Chin
BACKGROUND: Visceral obesity, low adiponectin, and severe obstructive sleep apnea (OSA) are associated with cardiovascular diseases, but the interactions among these factors on endothelial dysfunction are not well known. METHODS AND RESULTS: Endothelial function in 133 patients after polysomnography was evaluated as reactive hyperemia index (RHI) on reactive hyperemia peripheral arterial tonometry. Visceral obesity was defined as visceral fat area ≥100 cm(2)on computed tomography...
2015: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/25801692/effects-of-adenotonsillectomy-on-plasma-inflammatory-biomarkers-in-obese-children-with-obstructive-sleep-apnea-a-community-based-study
#9
L Kheirandish-Gozal, A Gileles-Hillel, M L Alonso-Álvarez, E Peris, R Bhattacharjee, J Terán-Santos, J Duran-Cantolla, D Gozal
BACKGROUND: Obesity and obstructive sleep apnea syndrome (OSA) are highly prevalent and frequently overlapping conditions in children that lead to systemic inflammation, the latter being implicated in the various end-organ morbidities associated with these conditions. AIM: To examine the effects of adenotonsillectomy (T&A) on plasma levels of inflammatory markers in obese children with polysomnographically diagnosed OSA who were prospectively recruited from the community...
July 2015: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/25724554/chronic-intermittent-hypoxia-leads-to-insulin-resistance-and-impaired-glucose-tolerance-through-dysregulation-of-adipokines-in-non-obese-rats
#10
Cuiping Fu, Liyan Jiang, Fen Zhu, Zilong Liu, Wenjing Li, Hong Jiang, Hongying Ye, Clete A Kushida, Shanqun Li
BACKGROUND AND OBJECTIVES: The aim of this study was to determine whether chronic intermittent hypoxia (CIH) could affect the secretion of adipokines, such as resistin, leptin, and adiponectin, in non-obese rats and to investigate the potential mechanisms. METHODS: An established rodent model of CIH was utilized, in which rats were exposed to varying oxygen levels (7-21 %) respectively over a period of 5 weeks. The area under the curve (AUCG) and the insulin resistance index (homeostasis model of assessment for insulin resistance index, HOMA-IR) were calculated...
December 2015: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/25700870/meta-analyses-of-the-association-of-sleep-apnea-with-insulin-resistance-and-the-effects-of-cpap-on-homa-ir-adiponectin-and-visceral-adipose-fat
#11
Imran H Iftikhar, Camilla M Hoyos, Craig L Phillips, Ulysses J Magalang
OBJECTIVE: We sought to conduct an updated meta-analysis of randomized controlled trials (RCTs) on the effect of continuous positive airway pressure (CPAP) on insulin resistance, as measured by homeostasis model assessment of insulin resistance (HOMA-IR), visceral abdominal fat (VAF), and adiponectin. Additionally, we performed a separate meta-analysis and meta-regression of studies on the association of insulin resistance and obstructive sleep apnea (OSA). METHODS: All included studies were searched from PubMed (from conception to March 15, 2014)...
April 2015: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/25276370/adiponectin-protects-rat-heart-from-left-ventricular-remodeling-induced-by-chronic-intermittent-hypoxia-via-inhibition-of-tgf-%C3%AE-smad2-3-pathway
#12
Wen-Xiao Ding, Yan-Bin Dong, Ning Ding, Xiao-Feng Zhang, Shi-Jiang Zhang, Xi-Long Zhang, Jian-Nan Liu, Gan Lu
OBJECTIVE: Obstructive sleep apnea syndrome (OSAS) is associated with many cardiovascular disorders. Chronic intermittent hypoxia (CIH) is the primary player in OSAS of the many associated factors. This study was in order to investigate the effects of the Adiponectin (Ad) on left ventricular remodeling induced by CIH. METHODS: Forty-five rats were randomly divided into three groups: normal control (NC) group, CIH group and CIH plus Ad supplemented (CIH + Ad) group...
September 2014: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/25238542/the-systemic-inflammome-of-severe-obesity-before-and-after-bariatric-surgery
#13
Ebymar Arismendi, Eva Rivas, Alvar Agustí, José Ríos, Esther Barreiro, Josep Vidal, Robert Rodriguez-Roisin
INTRODUCTION: Obesity is associated with low-grade systemic inflammation. The "inflammome" is a network layout of the inflammatory pattern. The systemic inflammome of obesity has not been described as yet. We hypothesized that it can be significantly worsened by smoking and other comorbidities frequently associated with obesity, and ameliorated by bariatric surgery (BS). Besides, whether or not these changes are mirrored in the lungs is unknown, but obesity is often associated with pulmonary inflammation and bronchial hyperresponsiveness...
2014: PloS One
https://www.readbyqxmd.com/read/24982545/study-of-leptin-and-adiponectin-as-disease-markers-in-subjects-with-obstructive-sleep-apnea
#14
Sana Al Mutairi, Olusegun A Mojiminiyi, Alia Al Alawi, Tahani Al Rammah, Nabila Abdella
BACKGROUND: Published studies showed conflicting results of the associations between adiponectin and leptin levels and obstructive sleep apnoea (OSA). In obese patients, plasma leptin is elevated and adiponectin is decreased, and we postulate that these adipokines could be potential markers of clinical and metabolic perturbations in patients with OSA. METHODS: 147 patients with suspected OSA had polysomnography to determine the Respiratory Disturbance Index (RDI)...
2014: Disease Markers
https://www.readbyqxmd.com/read/24966468/abnormal-cytokine-profile-in-patients-with-obstructive-sleep-apnea-hypopnea-syndrome-and-erectile-dysfunction
#15
Izolde Bouloukaki, Vaios Papadimitriou, Frank Sofras, Charalampos Mermigkis, Violeta Moniaki, Nikolaos M Siafakas, Sophia E Schiza
Patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) show a high prevalence of erectile dysfunction (ED). Although the underlying pathogenesis is still unknown, endothelial dysfunction, induced by inflammatory cytokines, chemokines, and adhesion molecules, has been proposed as a possible mechanism. The aim of this study was to assess whether OSAHS is associated with activation of the inflammatory cytokine system in patients with ED compared to the matched OSAHS patients with normal sexual function...
2014: Mediators of Inflammation
https://www.readbyqxmd.com/read/24856648/impact-of-obstructive-sleep-apnea-on-the-24-h-metabolic-hormone-profile
#16
M Sánchez-de-la-Torre, A Barceló, J Piérola, M de la Peña, J Valls, F Barbé
OBJECTIVE: Obstructive sleep apnea (OSA) has been associated with metabolic disorders. Sleep-disordered breathing could generate an altered rhythm in the expression of metabolic hormones, which could predispose to metabolic disorders. The aim of this study was to evaluate the effect of sleep apnea on diurnal variations in metabolic hormones. METHODS: Thirty-seven male, newly diagnosed, patients with OSA with an apnea-hypopnea index (AHI) > or = 20/h and 11 male controls (AHI <10/h) matched for body mass index (±3 kg/m2) were included...
June 2014: Sleep Medicine
https://www.readbyqxmd.com/read/24741853/early-diurnal-variation-of-serum-leptin-and-adiponectin-in-nontreated-obstructive-sleep-apnea-disease-a-prospective-observational-study
#17
Madalina Macrea, Thomas Martin, Hara Misra
BACKGROUND: Obstructive sleep apnea (OSA) is a common disorder resulting in a myriad of adverse vascular risks, including altered inflammatory/anti-inflammatory adipokine balance. Recent studies are yet to agree on how this balance responds to the OSA severity. As it is customary in these studies to obtain a single blood sample in participants after completion of the nocturnal polysomnogram (PSG), we hypothesized that these adipokines' early ultradian pulsatility might contribute to the reported contradictory results...
February 2014: Connecticut Medicine
https://www.readbyqxmd.com/read/24718591/adiponectin-protects-rat-myocardium-against-chronic-intermittent-hypoxia-induced-injury-via-inhibition-of-endoplasmic-reticulum-stress
#18
Wenxiao Ding, Xiaofeng Zhang, Hanpeng Huang, Ning Ding, Shijiang Zhang, Sean Z Hutchinson, Xilong Zhang
Obstructive sleep apnea syndrome (OSAS) is associated with many cardiovascular disorders such as heart failure, hypertension, atherosclerosis, and arrhythmia and so on. Of the many associated factors, chronic intermittent hypoxia (CIH) in particular is the primary player in OSAS. To assess the effects of CIH on cardiac function secondary to OSAS, we established a model to study the effects of CIH on Wistar rats. Specifically, we examined the possible underlying cellular mechanisms of hypoxic tissue damage and the possible protective role of adiponectin against hypoxic insults...
2014: PloS One
https://www.readbyqxmd.com/read/24638729/alteration-of-inflammatory-mediators-in-patients-with-obstructive-sleep-apnea
#19
Ana Lapuente Torrents, Bienvenido Barreiro, Montserrat Alsina, Lourdes Lozano, Josep Lluis Heredia
SESSION TITLE: Comorbidities of OSA PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: The aim of our study was to determine the relationship between some inflammatory mediators, Obstructive Sleep Apnea (OSA) and the Metabolic Syndrome (MS). METHODS: A total of 140 patients with clinical suspicion of OSA were studied from January 2007 to January 2008. Anthropometric data, smoking history and treatment were collected in all cases...
March 1, 2014: Chest
https://www.readbyqxmd.com/read/24634623/impact-of-osa-on-biological-markers-in-morbid-obesity-and-metabolic-syndrome
#20
Neus Salord, Mercè Gasa, Mercedes Mayos, Ana Maria Fortuna-Gutierrez, Josep Maria Montserrat, Manuel Sánchez-de-la-Torre, Antonia Barceló, Ferran Barbé, Núria Vilarrasa, Carmen Monasterio
BACKGROUND AND OBJECTIVE: There is compelling evidence that obstructive sleep apnoea (OSA) can affect metabolic syndrome (MetS) and cardiovascular risk, but the intermediate mechanisms through which it occurs have not been well defined. We explored the impact of OSA in morbidly obese patients with MetS on adipokines, pro-inflammatory markers, endothelial dysfunction, and atherosclerosis markers. METHODS: We included 52 morbidly obese patients in an observational study matched for age, gender and central obesity in 3 groups (OSA-MetS, Non-OSA-MetS, and Non OSA-non-MetS)...
March 15, 2014: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
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