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CS protein

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https://www.readbyqxmd.com/read/28918435/infant-avoidance-training-alters-cellular-activation-patterns-in-prefronto-limbic-circuits-during-adult-avoidance-learning-ii-cellular-imaging-of-neurons-expressing-the-activity-regulated-cytoskeleton-associated-protein-arc-arg3-1
#1
Nicole Gröger, Anja Mannewitz, Jörg Bock, Susann Becker, Katja Guttmann, Gerd Poeggel, Katharina Braun
Positive and negative feedback learning is essential to optimize behavioral performance. We used the two-way active avoidance (TWA) task as an experimental paradigm for negative feedback learning with the aim to test the hypothesis that neuronal ensembles activate the activity-regulated cytoskeletal (Arc/Arg3.1) protein during different phases of avoidance learning and during retrieval. A variety of studies in humans and other animals revealed that the ability of aversive feedback learning emerges postnatally...
September 16, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28913776/interactions-of-antisera-to-different-chlamydia-and-chlamydophila-species-with-the-ribosomal-protein-rps27a-correlate-with-impaired-protein-synthesis-in-a-human-choroid-plexus-papilloma-cell-line
#2
Abdullah Almamy, Christian Schwerk, Horst Schroten, Hiroshi Ishikawa, Abdul Rahman Asif, Bernhard Reuss
Chlamydia trachomatis (CT) and the Chlamydophila species (CS) Chlamydophila pneumoniae (CPn), and Chlamydophila psittaci (CPs) are suggested to induce autoantibodies causative of several human autoimmune disorders like rheumatoid arthritis and systemic lupus erythematosus (SLE). The aim of the present study was therefore to identify cellular protein interaction partners with antisera to CT (α-CT) or CS (α-CS) and to identify functional consequences of such interaction in vitro. As detected with a commercial first trimester human prenatal brain multiprotein array (hEXselect, Engine, Germany), the most frequent interaction partner with both α-CT and α-CS was the ribosomal small subunit protein RPS27a...
September 14, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28912867/protective-effect-of-controlled-release-of-cytokine-response-modifier-a-from-chitosan-microspheres-on-rat-chondrocytes-from-interleukin-1%C3%AE-induced-inflammation-and-apoptosis
#3
Pang-Hu Zhou, Lei Shi, Bo Qiu
The aim of the present study was to investigate the protective effect of cytokine response modifier A (CrmA) released from chitosan (CS) microspheres in a controlled manner on interleukin (IL)-1β-induced inflammation and apoptosis in chondrocytes. The CrmA release kinetics were characterized by an initial burst release, which was reduced to a linear release over 8 days. Furthermore, chondrocytes were isolated from 1-week-old Sprague Dawley rats. The cell culture was established by stimulation with 10 ng/ml IL-1β and subsequent incubation with CS-CrmA microspheres...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28911812/relationships-between-residue-voronoi-volume-and-sequence-conservation-in-proteins
#4
Jen-Wei Liu, Chih-Wen Cheng, Yu-Feng Lin, Shao-Yu Chen, Jenn-Kang Hwang, Shih-Chung Yen
BACKGROUND: Functional and biophysical constraints can cause different levels of sequence conservation in proteins. Previously, structural properties, e.g., relative solvent accessibility (RSA) and packing density of the weighted contact number (WCN), have been found to be related to protein sequence conservation (CS). The Voronoi volume has recently been recognized as a new structural property of the local protein structural environment reflecting CS. However, for surface residues, it is sensitive to water molecules surrounding the protein structure...
September 11, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28904431/role-of-gut-derived-uremic-toxins-on-oxidative-stress-and-inflammation-in-patients-with-chronic-kidney-disease
#5
S Gouroju, P V L N Srinivasa Rao, A R Bitla, K S Vinapamula, S M Manohar, S Vishnubhotla
Several cardiovascular disease (CVD) risk factors have been identified among patients with chronic kidney disease (CKD). Gut-derived uremic toxins (GDUT) are important modifiable contributors in this respect. There are very few Indian studies on GDUT changes in CKD. One hundred and twenty patients older than 18 years diagnosed with CKD were enrolled along with forty healthy subjects. The patients were classified into three groups of forty patients based on stage of CKD. Indoxyl sulfate (IS), para cresyl sulfate (p-CS), indole acetic acid (IAA), and phenol were estimated along with the assessment of oxidative stress (OS), inflammatory state, and bone mineral disturbance...
September 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28902637/development-of-fish-collagen-bioactive-glass-chitosan-composite-nanofibers-as-a-gtr-gbr-membrane-for-inducing-periodontal-tissue-regeneration
#6
Tian Zhou, Xin Liu, Baiyan Sui, Chao Liu, Xiumei Mo, Jiao Sun
The development of a guided tissue or bone regeneration (GTR/GBR) membrane with excellent performance has been a major challenge in the biomedical field. The present study was designed to prepare a biomimetic electrospun fish collagen/bioactive glass/chitosan (Col/BG/CS) composite nanofiber membrane and determine its structure, mechanical property, antibacterial activity, and biological effects on human periodontal ligament cells (HPDLCs). The effects of this composite membrane on inducing periodontal tissue regeneration were evaluated using a dog class II furcation defect model...
September 13, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28890654/chondroitin-sulfate-inhibits-monocyte-chemoattractant-protein-1-release-from-3t3-l1-adipocytes-a-new-treatment-opportunity-for-obesity-related-inflammation
#7
Thomas V Stabler, Eulàlia Montell, Josep Vergés, Janet L Huebner, Virginia Byers Kraus
Monocyte chemoattractant protein-1 (MCP-1) overproduction from inflamed adipose tissue is a major contributor to obesity-related metabolic syndromes. 3T3-L1 embryonic fibroblasts were cultured and differentiated into adipocytes using an established protocol. Adipocytes were treated with lipopolysaccharide (LPS) to induce inflammation and thus MCP-1 release. At the same time, varying concentrations of chondroitin sulfate (CS) were added in a physiologically relevant range (10-200 µg/mL) to determine its impact on MCP-1 release...
2017: Biomarker Insights
https://www.readbyqxmd.com/read/28889773/sensitivity-of-npcr-for-four-types-of-membrane-protein-dna-and-of-two-pairs-of-primers-for-tpp47-dna-of-treponema-pallidum-in-whole-blood-of-congenital-syphilis-newborns
#8
Yafei Guan, Rong Ding, Yequn Zhou, Xiaoqin Chen, Xiaolin Miao, Ye Zhang, Dan Luo, Shudong Cui
BACKGROUND: Problems exist in congenital syphilis (CS) diagnosis and no single test can be used to diagnose CS. OBJECTIVE: To know whether there exit differences of nPCR sensitivity among four membrane protein DNA and of nPCR between two pairs of primers for Tpp47. METHODS: We collected 30 CS patients as study group, and 20 cases admitted to hospital for other reasons as control group. The blood samples from newborns were left of blood for other examination, not special for the study...
September 10, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28887308/uncovering-human-mettl12-as-a-mitochondrial-methyltransferase-that-modulates-citrate-synthase-activity-through-metabolite-sensitive-lysine-methylation
#9
Jędrzej Małecki, Magnus E Jakobsson, Angela Y Y Ho, Anders Moen, Arild Rustan, Pål Ø Falnes
Lysine methylation is an important and much-studied posttranslational modification of nuclear and cytosolic proteins, but is present also in mitochondria. However, the responsible mitochondrial lysine-specific methyltransferases (KMTs) remain largely elusive. Here, we investigated METTL12, a mitochondrial human S-adenosylmethionine (AdoMet)-dependent methyltransferase, and found it to methylate a single protein in mitochondrial extracts, identified as citrate synthase (CS). Using several in vitro and in vivo approaches, we demonstrated that METTL12 methylates CS on Lys-395, which is localized in the CS active site...
September 8, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28886998/propolis-reversed-cigarette-smoke-induced-emphysema-through-macrophage-alternative-activation-independent-of-nrf2
#10
Marina Valente Barroso, Isabella Cattani-Cavalieri, Lycia de Brito-Gitirana, Alain Fautrel, Vincent Lagente, Martina Schmidt, Luís Cristóvão Porto, Bruna Romana-Souza, Samuel Santos Valença, Manuella Lanzetti
Chronic obstructive pulmonary disease (COPD) is an incurable and progressive disease. Emphysema is the principal manifestation of COPD, and the main cause of this condition is cigarette smoke (CS). Natural products have shown antioxidant and anti-inflammatory properties that can prevent acute lung inflammation and emphysema, but there are few reports in the literature regarding therapeutic approaches to emphysema. We hypothesized that supplementation with natural extracts would repair lung damage in emphysema caused by CS exposure...
August 19, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28882005/cats-coordinates-of-atoms-by-taylor-series-protein-design-with-backbone-flexibility-in-all-locally-feasible-directions
#11
Mark A Hallen, Bruce R Donald
Motivation: When proteins mutate or bind to ligands, their backbones often move significantly, especially in loop regions. Computational protein design algorithms must model these motions in order to accurately optimize protein stability and binding affinity. However, methods for backbone conformational search in design have been much more limited than for sidechain conformational search. This is especially true for combinatorial protein design algorithms, which aim to search a large sequence space efficiently and thus cannot rely on temporal simulation of each candidate sequence...
July 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28881986/predicting-multicellular-function-through-multi-layer-tissue-networks
#12
Marinka Zitnik, Jure Leskovec
Motivation: Understanding functions of proteins in specific human tissues is essential for insights into disease diagnostics and therapeutics, yet prediction of tissue-specific cellular function remains a critical challenge for biomedicine. Results: Here, we present OhmNet , a hierarchy-aware unsupervised node feature learning approach for multi-layer networks. We build a multi-layer network, where each layer represents molecular interactions in a different human tissue...
July 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28880706/identification-of-cellular-responses-to-low-dose-radiation-by-the-profiling-of-phosphorylated-proteins-in-human-b-lymphoblast-im-9-cells
#13
Hyeon Soo Eom, Hyung Sun Park, Ga Eun You, Ji Young Kim, Seon Young Nam
PURPOSE: The aim of this study was to explore the potential for radiation-specific signaling of various LDIR-induced effects in human B-lymphoblast IM-9 cells. MATERIALS AND METHODS: Human lymphoblast IM-9 cells were exposed to ionization radiation at 0.1 and 2 Gy using a (137)Cs γ-irradiator at a dose rate of 0.8 Gy/min. Cell viability and DNA fragmentation was determined using MTT assay and TUNEL assay at 24 hr after irradiation. Profiling of protein phosphorylation by radiation was identified using a phospho-antibody array at 4 hr after irradiation and Dataset of the profiling was analyzed by IPA...
September 7, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28874846/hyaluronic-acid-coated-chitosan-nanoparticles-reduced-the-immunogenicity-of-the-formed-protein-corona
#14
Abdulaziz Almalik, Hicham Benabdelkamel, Afshan Masood, Ibrahim O Alanazi, Ibrahim Alradwan, Majed A Majrashi, Assim A Alfadda, Waleed M Alghamdi, Haitham Alrabiah, Nicola Tirelli, Ali H Alhasan
Studying the interactions of nanoparticles (NPs) with serum proteins is necessary for the rational development of nanocarriers. Optimum surface chemistry is a key consideration to modulate the formation of the serum protein corona (PC) and the resultant immune response. We investigated the constituent of the PC formed by hyaluronic acid-coated chitosan NPs (HA-CS NPs). Non-decorated chitosan NPs (CS NPs) and alginate-coated chitosan NPs (Alg-CS NPs) were utilized as controls. Results show that HA surface modifications significantly reduced protein adsorption relative to controls...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28873556/effect-of-porcine-plasma-protein-hydrolysates-on-long-term-retrogradation-of-corn-starch
#15
Haili Niu, Mingcheng Zhang, Xiufang Xia, Qian Liu, Baohua Kong
The potential effect of porcine plasma protein hydrolysates (PPPH) on the long-term retrogradation of corn starch (CS) was investigated. The differential scanning calorimetry results showed that PPPH significantly reduced the retrogradation enthalpies (ΔHr) of CS (P<0.05), obviously decreased the crystallization rate constant (k), and enhanced the Avrami exponent (n) (P<0.05). Low-field nuclear magnetic resonance analysis demonstrated that the spin-spin relaxation time (T2) remarkably increased with increasing PPPH concentration during storage at 4°C for 28days (P<0...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28873527/enzymes-loaded-chitosan-coconut-fibre-zinc-oxide-nanoparticles-strip-for-polyamine-determination
#16
Vinita Hooda, Archita
Most often, the immobilized enzyme based quantification is an attractive alternative to other chromatographic, electrochemical and mass spectrometry based methods due to its specificity and simplicity. In the present study, polyamine oxidase specific for spermine and spermidine and diamine oxidase specific for putrescine, were co-immobilized onto a novel chitosan/coconut fibre/zinc oxide nanoparticles (CS/CF/nZnO) hybrid support to yield a polyamine sensing strip. The strip worked optimally at pH 7.0, temperature 25°C and 6min of incubation time...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28873520/improvement-of-feed-pellet-characteristics-by-dietary-pre-gelatinized-starch-and-their-subsequent-effects-on-growth-and-physiology-in-tilapia
#17
Naga Kanmani, Nicholas Romano, Mahdi Ebrahimi, S M Nurul Amin, Mohd Salleh Kamarudin, Ali Karami, Vikas Kumar
A 9-week study was conducted to compare dietary corn starch (CS) or tapioca starch (TS), with or without being pre-gelatinized (PG), on the growth, feeding efficiencies, plasma and muscle biochemistry, intestinal short chain fatty acids (SCFA), and liver glycogen of triplicate groups of 20 red hybrid tilapia (Orecohromis sp.). Various pellet characteristics were evaluated, along with their surface and cross sectional microstructure. The PG diets had significantly higher water stability, bulk density, and protein solubility, along with a smoother surface...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28872143/creating-and-applying-a-reference-to-facilitate-the-discussion-and-classification-of-proteins-in-a-diverse-group
#18
D Ellen K Tarr
Related proteins that have been studied in different labs using varying organisms may lack a uniform system of nomenclature and classification, making it difficult to discuss the group as a whole and to place new sequences into the appropriate context. Developing a reference that prioritizes important sequence features related to structure and/or activity can be used in addition to established names to add some coherency to a diverse group of proteins. This paper uses the cysteine-stabilized alpha-helix (CS-αβ) superfamily as an example to show how a reference generated in spreadsheet software can clarify relationships between existing proteins in the superfamily, as well as facilitate the addition of new sequences...
August 16, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28865477/rig-i-overexpression-decreases-mortality-of-cigarette-smoke-exposed-mice-during-influenza-a-virus-infection
#19
Xiaoqiu Wang, Wenxin Wu, Wei Zhang, J Leland Booth, Elizabeth S Duggan, Lili Tian, Sunil More, Yan D Zhao, Ravindranauth N Sawh, Lin Liu, Ming-Hui Zou, Jordan P Metcalf
BACKGROUND: Retinoic acid-inducible gene I (RIG-I) is an important regulator of virus-induced antiviral interferons (IFNs) and proinflammatory cytokines which participate in clearing viral infections. Cigarette smoke (CS) exposure increases the frequency and severity of respiratory tract infections. METHODS: We generated a RIG-I transgenic (TG) mouse strain that expresses the RIG-I gene product under the control of the human lung specific surfactant protein C promoter...
September 2, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28851855/understanding-molecular-mechanism-of-improved-proliferation-and-osteogenic-potential-of-human-mesenchymal-stem-cells-grown-on-polyelectrolyte-complex-derived-from-non-mulberry-silk-fibroin-and-chitosan
#20
Akalabya Bissoyi, Abhishek Kumar Singh, Subrat Kumar Pattanayak, Arindam Bit, Sudip Kumar Sinha, Ashish Patel, Vishal Jain, Pradeep Kumar Patra
The development of engineered bone tissue, as a promising alternative to the conventional bone grafts, is not rewarding yet and remained challenging. Thus, attempts have been made in the present study to synthesize polyelectrolyte complex (PEC) scaffolds by blending of chitosan (CS) to silk fibroin (SF) derived from non-mulberry silkworm (Antheraea pernyi) at three different pH (5.0, 6.0, and 7.0), and characterize in terms of morphology, ultrastructure and mechanical properties with SEM, FTIR, XRD and tensile strength analyses...
August 30, 2017: Biomedical Materials
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