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CS protein

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https://www.readbyqxmd.com/read/28633280/motifhyades-expectation-maximization-for-de-novo-dna-motif-pair-discovery-on-paired-sequences
#1
Ka-Chun Wong
Motivation: In higher eukaryotes, protein-DNA binding interactions are the central activities in gene regulation. In particular, DNA motifs such as transcription factor binding sites are the key components in gene transcription. Harnessing the recently available chromatin interaction data, computational methods are desired for identifying the coupling DNA motif pairs enriched on long-range chromatin-interacting sequence pairs (e.g. promoter-enhancer pairs) systematically. Results: To fill the void, a novel probabilistic model (namely, MotifHyades) is proposed and developed for de novo DNA motif pair discovery on paired sequences...
June 13, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28631814/germination-assisted-enzymatic-hydrolysis-can-improve-the-quality-of-soybean-protein
#2
Hui Yang, Xin Li, Jinyan Gao, Ping Tong, Anshu Yang, Hongbing Chen
This study aimed to investigate the effects of combined germination and Alcalase hydrolysis on the quality of soybean protein. Protein profiles, water solubility, foaming and emulsifying properties, thixotropic properties, and in vitro protein digestibility (IVPD) were tested, the chemical score (CS), essential amino acid index (EAAI), and protein efficiency ratio (PER) of soybean protein were also defined. The combined treatment of germination and Alcalase hydrolysis remarkably improved the solubility, emulsification activity index, emulsion stability index, and foaming capacity of soybean protein...
June 20, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28630674/cation-effects-on-haemoglobin-aggregation-balance-of-chemisorption-against-physisorption-of-ions
#3
Drew F Parsons, Timothy T Duignan, Andrea Salis
A theoretical model of haemoglobin is presented to explain an anomalous cationic Hofmeister effect observed in protein aggregation. The model quantifies competing proposed mechanisms of non-electrostatic physisorption and chemisorption. Non-electrostatic physisorption is stronger for larger, more polarizable ions with a Hofmeister series Li(+)< K(+)< Cs(+). Chemisorption at carboxylate groups is stronger for smaller kosmotropic ions, with the reverse series Li(+) > K(+) > Cs(+). We assess aggregation using second virial coefficients calculated from theoretical protein-protein interaction energies...
August 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/28617322/chondroitin-sulfate-rich-extract-of-skate-cartilage-attenuates-lipopolysaccharide-induced-liver-damage-in-mice
#4
Yeong Ok Song, Mijeong Kim, Minji Woo, Jang-Mi Baek, Keon-Hee Kang, Sang-Ho Kim, Seong-Soo Roh, Chan Hum Park, Kap-Seop Jeong, Jeong-Sook Noh
The protective effects of a chondroitin sulfate-rich extract (CSE) from skate cartilage against lipopolysaccharide (LPS)-induced hepatic damage were investigated, and its mechanism of action was compared with that of chondroitin sulfate (CS) from shark cartilage. ICR mice were orally administrated 200 mg/kg body weight (BW) of CS or 400 mg/kg BW of CSE for 3 consecutive days, followed by a one-time intraperitoneal injection of LPS (20 mg/kg BW). The experimental groups were vehicle treatment without LPS injection (NC group), vehicle treatment with LPS injection (LPS group), CS pretreatment with LPS injection (CS group), and CSE pretreatment with LPS injection (CSE group)...
June 15, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28616017/inhibition-and-enhancement-of-neural-regeneration-by-chondroitin-sulfate-proteoglycans
#5
REVIEW
Heikki Rauvala, Mikhail Paveliev, Juha Kuja-Panula, Natalia Kulesskaya
The current dogma in neural regeneration research implies that chondroitin sulfate proteoglycans (CSPGs) inhibit plasticity and regeneration in the adult central nervous system (CNS). We argue that the role of the CSPGs can be reversed from inhibition to activation by developmentally expressed CSPG-binding factors. Heparin-binding growth-associated molecule (HB-GAM; also designated as pleiotrophin) has been studied as a candidate molecule that might modulate the role of CSPG matrices in plasticity and regeneration...
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28609623/single-step-enrichment-of-n-glycopeptides-and-phosphopeptides-with-novel-multifunctional-ti4-immobilized-dendritic-polyglycerol-coated-chitosan-nanomaterials
#6
Xiajuan Zou, Jianzheng Jie, Bin Yang
Protein glycosylation and phosphorylation, two of the most important post-translational modifications (PTMs) in the proteome play a vital role in regulating a number of complex biological processes and involvement in a variety of diseases. Comprehensive characterization of the phosphoproteome and glycoproteome requires highly specific and sensitive enrichment methods for purification of phosphopeptides and glycopeptides because many glycoproteins and phosphoproteins naturally occur at low abundances and substoichiometry...
June 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28608568/the-macrophage-activation-induced-by-bacillus-thuringiensis-cry1ac-protoxin-involves-erk1-2-and-p38-pathways-and-the-interaction-with-cell-surface-hsp70
#7
Néstor Rubio-Infante, Damaris Ilhuicatzi-Alvarado, Marilu Torres-Martínez, Juan Pablo Reyes-Grajeda, Raúl Nava-Acosta, Edith González-González, Leticia Moreno-Fierros
Here, we aimed to further characterize the mechanisms involved in protoxin (p) Cry1Ac-induced macrophage activation. We demonstrated that pCry1Ac induces MAPK ERK1/2, p38 and JNK phosphorylation in RAW264.7 macrophages. Because MAPK activation is mainly triggered via ligand-receptor interactions, we focused on the identification of potential pCry1Ac-receptor proteins. Flow cytometry and confocal analysis showed specific saturable pCry1Ac-binding to the macrophage surface and evidenced its internalization via the clathrin-pathway...
June 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28606841/effects-of-adding-corn-oil-and-soy-protein-to-corn-starch-on-the-physicochemical-and-digestive-properties-of-the-starch
#8
Xu Chen, Xiao-Wei He, Bin Zhang, Xiong Fu, Jay-Lin Jane, Qiang Huang
This study aimed to understand effects of adding corn oil (CO) and soy protein (SP) to corn starch on the physicochemical properties and digestive rates of annealed starch complex and mechanisms of interactions between corn starch (CS), CO and SP. Binary and ternary blends were prepared using CS mixed with CO (10%, dsb) and/or SP (10%, dsb) and incubated in a water bath at 50°C for 14h. Results showed that more agglomerates of the granules were in the ternary blends. With the addition of CO and/or SP, the CS displayed a decreased pasting temperature, an increased peak viscosity and a decreased enthalpy change of amylose-lipid complex dissociation...
June 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28597430/identification-of-drought-stress-related-proteins-from-1s-l-1b-chromosome-substitution-line-of-wheat-variety-chinese-spring
#9
Jiaxing Zhou, Chaoying Ma, Shoumin Zhen, Min Cao, Friedich J Zeller, Sai L K Hsam, Yueming Yan
BACKGROUND: Wheat, one of the most important crops, has a detrimental effect on both yield and quality under drought stress. As our preliminary experiment showed that the Chinese Spring wheat-Aegilops longissima chromosome substitution line CS-1S(l) (1B) had a better drought tolerance than CS, the substitution line CS-1S(l)(1B) was used to identify drought stress related proteins by means of a comparative proteome approach in this work. Our present study aimed to explore the gene resources for drought resistance in 1S(l) genome...
December 2016: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/28596293/the-uncoupling-of-autophagy-and-zinc-homeostasis-in-airway-epithelial-cells-as-a-fundamental-contributor-to-copd
#10
Eugene Roscioli, Hai Bac Tran, Hubertus Jersmann, Phan Tien Nguyen, Emily Hopkins, Susan Elizabeth Lester, Nigel Farrow, Peter D Zalewski, Paul N Reynolds, Sandra Hodge
The proper regulation of Zinc (Zn) trafficking proteins and the cellular distribution of Zn is critical for the maintenance of autophagic processes. However, there have been no studies which have examined Zn dyshomeostasis and the disease-related modulation of autophagy observed in the airways afflicted with COPD. We hypothesized that dysregulated autophagy in airway epithelial cells (AEC) is related to Zn dysregulation in cigarette smoke (CS)-induced COPD. We applied a human ex vivo air-liquid interface model, a murine model of smoke-exposure, and human lung tissues, and investigated Zn, ZIP1 and ZIP2 Zn-influx proteins, autophagy (Microtubule-associated 1A/1B-light chain-3 (LC3), Beclin-1), autophagic flux (Sequestosome), apoptosis (Bcl2; X-Linked Inhibitor of Apoptosis (XIAP), Poly (ADP)-ribose Polymerase (PARP)), and inflammation (TSLP, RANTES, and IL-1β)...
June 8, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28587384/upregulation-of-glutamate-metabolism-by-byhwd-in-cultured-astrocytes-following-oxygen-glucose-deprivation-reoxygenation-in-part-depends-on-the-activation-of-p38-mapk
#11
Peng Yu, Li Guan, Lequan Zhou, Jianchao Guo, Ruixian Guo, Ruishan Lin, Wenting Ding, Xiaoying Li, Wei Liu
Recent studies have demonstrated that Buyang Huanwu Decoction (BYHWD) decreased glutamate levels subsequent to cerebral ischemia. Glutamate transporter-1 (GLT-1) and glutamine synthetase (GS), which are located in astrocytes, mainly contribute to glutamate transportation, thus reducing glutamate concentration. BYHWD has previously been demonstrated to upregulate GLT-1 and GS following ischemia in vivo. However, whether BYHWD can directly influence astrocytic GLT-1/GS levels remains unknown. In the present study, the effect of BYHWD containing serum (BYHWD-CS) on GLT-1/GS levels in astrocytes following oxygen-glucose deprivation/reoxygenation (OGD/R) was investigated...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28586015/evaluation-of-the-anti-inflammatory-actions-of-various-functional-food-materials-including-glucosamine-on-synovial-cells
#12
Yoshie Yamagishi, Akimasa Someya, Kensuke Imai, Junji Nagao, Isao Nagaoka
The anti-inflammatory actions of glucosamine (GlcN) on arthritic disorders involve the suppression of inflammatory mediator production from synovial cells. GlcN has also been reported to inhibit the activation of the p38 mitogen-activated protein kinase (MAPK) pathway. The present study aimed to determine the cooperative and anti‑inflammatory actions of functional food materials and evaluated the production of interleukin (IL)‑8 and phosphorylation of p38 MAPK in IL-1β-activated synovial cells, incubated with the combination of GlcN and various functional food materials containing L‑methionine (Met), undenatured type II collagen (UC‑II), chondroitin sulfate (CS), methylsulfonylmethane (MSM) and agaro-oligosaccharide (AO)...
June 6, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28576004/preparation-of-poly-lactic-co-glycolic-acid-and-chitosan-composite-nanocarriers-via-electrostatic-self-assembly-for-oral-delivery-of-insulin
#13
Bin Xu, Guohua Jiang, Weijiang Yu, Depeng Liu, Yongkun Liu, Xiangdong Kong, Juming Yao
To improve insulin bioavailability and overcome multiple barriers for oral delivery of insulin, the composite nanocarriers (PLGA/FA-CS) prepared from poly(lactide-co-glycoside) (PLGA) and folic acid modified chitosan (FA-CS) were fabricated via electrostatic self-assembly method. The resultant composite nanocarriers exhibited low cytotoxicity against HT-29 cells and excellent stability against protein solution. The chemical stability of loaded insulin against digestive enzyme were established in presence of simulated gastric fluid (SGF) containing pepsin and simulated intestinal fluid (SIF) containing pancreatin, respectively...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28575972/photoenhanced-gene-transfection-by-a-curcumin-loaded-cs-g-pzll-micelle
#14
Jian-Tao Lin, Wen-Jia Pan, Jun-Ai Zhang, Wei Wang, Jia Zhong, Jia-Min Su, Tong Li, Ying Zou, Guan-Hai Wang
The codelivery of drug and gene is a promising method for cancer treatment. In our previous works, we prepared a cationic micelles based on chitosan and poly-(N-3-carbobenzyloxylysine) (CS-g-PZLL), but transfection ratio of CS-g-PZLL to Hela cell was low. Herein, to improve the transfection efficiency of CS-g-PZLL, curcumin was loaded in the CS-g-PZLL micelle. After irradiation, the obtained curcumin loaded micelle showed a better transfection, and the p53 protein expression in Hela cells was higher. The apoptosis assay showed that the complex could induce a more significant apoptosis to Hela cells than that of curcumin or p53 used alone, and the curcumin loaded micelle inducing apoptosis was best after irradiation...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28566717/metabolomic-profiling-in-a-hedgehog-interacting-protein-hhip-murine-model-of-chronic-obstructive-pulmonary-disease
#15
Emily S Wan, Yan Li, Taotao Lao, Weiliang Qiu, Zhiqiang Jiang, John D Mancini, Caroline A Owen, Clary Clish, Dawn L DeMeo, Edwin K Silverman, Xiaobo Zhou
Genetic variants annotated to the hedgehog interacting protein (HHIP) are robustly associated with chronic obstructive pulmonary disease (COPD). Hhip haploinsufficiency in mice leads to increased susceptibility towards the development of emphysema following exposure to chronic cigarette smoke (CS). To explore the molecular pathways which contribute to increased susceptibility, we performed metabolomic profiling using high performance liquid chromatography tandem mass spectroscopy (LC/MS-MS) on plasma, urine, and lung tissue of Hhip (+/-) heterozygotes and wild type (Hhip (+/+)) C57/BL6 mice exposed to either room-air or CS for six months...
May 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28551631/aberration-of-p73-promoter-methylation-in-chondrosarcoma
#16
Pei Liu, Cassandra Garbutt, Francis J Hornicek, Fuyun Liu, Zhenfeng Duan
BACKGROUND: p73 is a tumor-suppressor gene with significant homology to p53. Abnormal promoter methylation of p73 is present in different types of cancer. However, the promoter methylation status of p73 in chondrosarcoma (CS) is unknown. MATERIALS AND METHODS: p73 promoter methylation status was evaluated by quantitative polymerase chain reaction (PCR), p73 protein expression by western blot, and the relationship between p73 methylation and clinical data was analyzed...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28549478/gladiator-a-global-approach-for-elucidating-disease-modules
#17
Yael Silberberg, Martin Kupiec, Roded Sharan
BACKGROUND: Understanding the genetic basis of disease is an important challenge in biology and medicine. The observation that disease-related proteins often interact with one another has motivated numerous network-based approaches for deciphering disease mechanisms. In particular, protein-protein interaction networks were successfully used to illuminate disease modules, i.e., interacting proteins working in concert to drive a disease. The identification of these modules can further our understanding of disease mechanisms...
May 26, 2017: Genome Medicine
https://www.readbyqxmd.com/read/28549249/cd146-mcam-in-human-cs-dlk1-cs-cd34-adipose-stromal-progenitor-cells
#18
Susanne Hörl, Asim Ejaz, Sebastian Ernst, Monika Mattesich, Andreas Kaiser, Brigitte Jenewein, Marit E Zwierzina, Sarina Hammerle, Carina Miggitsch, Maria C Mitterberger-Vogt, Claudia Krautgasser, Gerhard Pierer, Werner Zwerschke
To precisely characterize CD146 in adipose stromal/progenitor cells (ASCs) we sorted the stromal vascular faction (SVF) of human abdominal subcutaneous white adipose tissue (sWAT) according to cell surface (cs) expression of CD146, DLK1 and CD34. This test identified three main SVF cell populations: ~50% cs-DLK1(-)/cs-CD34(+)/cs-CD146(-) ASCs, ~7.5% cs-DLK1(+)/cs-CD34(dim/+)/cs-CD146(+) and ~7.5% cs-DLK1(+)/cs-CD34(dim/+)/cs-CD146(-) cells. All cells contained intracellular CD146. Whole mount fluorescent IHC staining of small vessels detected CD146(+) endothelial cells (CD31(+)/CD34(+)/CD146(+)) and pericytes (CD31(-)/CD34(-)/CD146(+) ASCs)...
May 17, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28547884/lack-of-transgene-and-glyphosate-effects-on-yield-and-mineral-and-amino-acid-content-of-glyphosate-resistant-soybean
#19
Stephen O Duke, Agnes M Rimando, Krishna N Reddy, James V Cizdziel, Nacer Bellaloui, David R Shaw, Martin M Williams, Jude E Maul
BACKGROUND: There has been controversy as to whether the glyphosate resistance gene and/or glyphosate applied to glyphosate-resistant (GR) soybean affect the content of cationic minerals (especially Mg, Mn, and Fe), yield and amino acid content of GR soybean. A two-year field study (2013 and 2014) examined these questions at sites in Mississippi, USA. RESULTS: There were no effects of glyphosate, the GR transgene, or field crop history (for a field with both no history of glyphosate use versus one with a long history of glyphosate use) on grain yield...
May 25, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28546542/low-cesium-rice-mutation-in-ossos2-reduces-radiocesium-in-rice-grains
#20
Satoru Ishikawa, Shimpei Hayashi, Tadashi Abe, Masato Igura, Masato Kuramata, Hachidai Tanikawa, Manaka Iino, Takashi Saito, Yuji Ono, Tetsuya Ishikawa, Shigeto Fujimura, Akitoshi Goto, Hiroki Takagi
In Japan, radiocesium contamination in foods has become of great concern and it is a primary issue to reduce grain radiocesium concentration in rice (Oryza sativa L.). Here, we report a low-cesium rice mutant 1 (lcs1) with the radiocesium concentration in grain about half that in the wild-type cultivar. Genetic analyses revealed that a mutation in OsSOS2, which encodes a serine/threonine-protein kinase required for the salt overly sensitive (SOS) pathway in plants, is responsible for the decreased cesium (Cs) concentrations in lcs1...
May 25, 2017: Scientific Reports
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